Relevant bibliographies by topics / GRBL

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
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Academic literature on the topic 'GRBL'

Author: Grafiati
Published: 4 June 2021
Last updated: 5 February 2022

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Journal articles on the topic "GRBL"

1

Muchlis, Andre, Wrastawa Ridwan, and Iskandar Zulkarnain Nasibu. "Rancang Bangun Mesin CNC (Computer Numerical Control) Laser dengan Metode Design for Assembly." Jambura Journal of Electrical and Electronics Engineering 3, no. 1 (January 9, 2021): 23–27. http://dx.doi.org/10.37905/jjeee.v3i1.9228.

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CNC Laser (Computer Numerical Control) adalah alat yang memiliki fungsi untuk mengukir/mencetak berbagai tulisan dan kaliqrafi secara otomatis berdasarkan media yang digunakan seperti Acrilic, Fiber, Almunium, dan kayu. Perancangan CNC laser menggunakan metode Design For Assembly Boothroyd (DFA), G-Code, dan Closed Loop System (Loop Tertutup). Kelebihan metode DFA yaitu mengestimasikan pengurangan waktu perakitan. Metode G-Code lebih ke menyatukan gerakan yang akan di lakukan mesin, seperti bergeser ke titik A, titik B. Kemudian pada metode Closed Loop System (Loop Tertutup) bekerja mengirim sinyal umpan balik ke pengendali untuk mengecilkan kesalahan sistem. Hasil pengujian dari komponen pada masing-masing alat secara keseluruhan berupa input dan output menjadi kesatuan alat mesin CNC laser cutting dan engraver. Software GRBL dihubungkan pada CNC shild. GRBL mengirim G-Code ke arduino dan menerjemahkan isi dari G-Code satu persatu untuk menghasilkan pergerakan motor stepper dan cahaya laser. Telah didapatkan sistem pengontrolan mesin laser engravir yang bisa menggerakkan mesin kearah dua sumbu X dan Y, yang tersusun dari beberapa komponen yaitu komputer, kontroler arduino nano, motor stepper, laser module, power supplay dan emergency stop. Pengujian laser engraver dilakukan dengan medium plywood dan berbagai pola gambar. Hasil pengujian menunjukkan alat dapat bekerja sesuai dengan pola gambar yang ada.CNC Laser (Computer Numerical Control) tools that have a function to automatically engrave / print various writings and kaliqrafi based on the media used such as Acrilic, Fiber, Aluminum, and wood. CNC laser design uses the Design For Assembly Boothroyd (DFA), G-Code, and Closed Loop System (Closed Loop) method. The advantage of the DFA method is that it estimates the reduced assembly time. The G-Code method is more about unifying the movements that the machine will do, such as moving from point A to point B. Then the Closed Loop System method works to send a feedback signal to the controller to minimize system errors. The test results of the components on each tool as a whole are in the form of input and output into a unity of the CNC laser cutting and engraver machine tool. GRBL software is linked to the CNC shild. The GRBL sends the G-Code to the Arduino and translates the contents of the G-Code one by one to produce stepper motor movement and laser light. A schematic of a laser engraving machine control system that is able to move the machine towards two axes X and Y, which is composed of several components, namely a computer, Arduino nano controller, stepper motor, laser module, power supply and emergency stop. Laser engraver testing was carried out using plywood and various image patterns. The test results show that the tool can work in accordance with existing image patterns.
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Sopandi, Wahyu, Didi Sukyadi, and Rendi Restiana Sukardi. "The Implementation of Guided Research - Based Learning with Graduate School Students of an Elementary Education Study Program." Pedagogika 134, no. 2 (October 18, 2019): 82–98. http://dx.doi.org/10.15823/p.2019.134.5.

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The research aims to investigate how guided research-based learning (GRBL) helps students of an Elementary Education Study Program (EESP) in carrying out research and preparing scientific articles, besides mastering the fundamental concepts of science. This is an experimental one-shot case study research design, which involved seven master’s degree students from our EESP. The result shows that students’ capability is improved, but they still face difficulties in every step of writing publishable scientific articles.
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de VET, Edwin C. J. M., Begoña AGUADO, and R. Duncan CAMPBELL. "Adaptor signalling proteins Grb2 and Grb7 are recruited by human G6f, a novel member of the immunoglobulin superfamily encoded in the MHC." Biochemical Journal 375, no. 1 (October 1, 2003): 207–13. http://dx.doi.org/10.1042/bj20030293.

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The human G6f protein, which is encoded by a gene in the MHC, is a putative cell-surface receptor belonging to the immunoglobulin superfamily. The intracellular tail of G6f is 40 amino acids in length and contains one tyrosine residue (Y281), which is phosphorylated after treatment of cells with pervanadate. This tyrosine residue is found in a consensus-binding motif (YXN) for the Src homology 2 domains of Grb2 and Grb7 (where Grb stands for growth-factor-receptor-bound protein). Glutathione S-transferase pull-down assays showed that the interaction of G6f with both Grb2 and Grb7 is mediated through the Src homology 2 domains of these two proteins and is dependent on the phosphorylation of G6f. Immunoprecipitation experiments showed the interaction of full-length phosphorylated G6f with both full-length Grb2 and Grb7. Antibody cross-linking of G6f expressed in K562 cells resulted in a transient phosphorylation of p42/44 MAP kinase (also known as extracellular-signal-regulated protein kinase-1/2; MAP stands for mitogen-activated protein) which could be prevented by MAP kinase kinase (MEK) inhibitors. These results suggest a coupling of G6f with downstream signal transduction pathways involving Grb2 and Grb7, including the Ras–MAP kinase pathway.
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Praminasari, Reski. "Perancangan Pen Plotter Tiga Sumbu Berbasis Mikrokontroller Arduino." Jurnal Teknologi Elekterika 15, no. 2 (November 30, 2018): 35. http://dx.doi.org/10.31963/elekterika.v15i2.1496.

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Perancangan Pen Plotter Tiga Sumbu Berbasis Mikrokontroller Arduino bertujuan untuk merancang alat pencetak jalur rangkaian elektronika yang praktis dan efisien. Alat ini bekerja dengan menampilkan gambar pada meja kerja sesuai dengan kode yang diterima oleh arduino yang disebut G-Code, yang sebelumnya berbentuk atau berekstensi file gambar dari aplikasi Inkscape dan dikonversi oleh aplikasi Makercam kemudian di unggah oleh aplikasi Xloader serta pergerakannya dikontrol oleh Grbl Controller. Dari hasil pengujian Pen Plotter ini, maka disimpulkan bahwa alat ini dapat mencetak jalur rangkaian elektronika sederhana dan gambar yang beragam melalui aplikasi Inkscape dan Makercam.
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Jufrizaldy, Muhammad, Ilyas Ilyas, and Marzuki Marzuki. "RANCANG BANGUN MESIN CNC MILLING MENGGUNAKAN SYSTEM KONTROL GRBL UNTUK PEMBUATAN LAYOUT PCB." Jurnal Mesin Sains Terapan 4, no. 1 (February 28, 2020): 37. http://dx.doi.org/10.30811/jmst.v4i1.1743.

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Mesin CNC milling adalah mesin potong berbasis komputer yang dapat menjalankan proses secara otomatis pada berbagai macam perintah berbasis bahan yang telah diprogram ke dalam perangkat lunak. Pada tugas akhir kali ini akan dirancang dan diimplementasikan CNC (Computer Numerical Control) Router dengan menggunakan Program G-Code dengan menggunakan GBRL Kontroller sebagai pengontrol mesin CNC. Mikrokontroler digunakan untuk menerima G-Code dari PC yang dikirim ke mikrokontroler yang selanjutnya dikontrol menggunakan GBRL kontroller untuk menggerakan motor Stepper. Mesin CNC ini dikendalikan dengan menggunakan software GRBL dimana ketika program dimasukkan kedalam software tersebut, stepper motor, spindle serta mata bor akan bergerak. Perancangan ini menggunakan 3 buah stepper motor dimana setiap stepper motor berfungsi untuk menggerakkan sumbu X, Y dan Z. Spindle digunakan sebagai pengendali mata bor yang berfungsi untuk mengukir layout pada PCB.Kata kunci : Motor Stepper NEMA , Driver Motor Board T, Breakout Board , Power supply , Spindle Kit
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Suwandi, Herwani, and Septian Tri Setianto. "ANALISA SOFTWARE GRBL CONTROLLER UNTUK MESIN MINI CNC PLOTTER 3 - AXIS DENGAN MENGGUNAKAN MIKRO KONTROLER ATMEGA 328." TEKNOKOM 2, no. 1 (March 26, 2019): 57–64. http://dx.doi.org/10.31943/teknokom.v2i1.17.

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Dalam sebuah industri khususnya manufaktur terdapat mesin CNC dengan berbagai macam jenis sepertiMilling, Frais, Bubut dan banyak lagi yang berfungsi untuk membuat suatu bahan mentah dari besi yang diukir menjadi suatu barang yang berguna bagi kebutuhan manusia, yang biasanya terdiri dari 2 hingga 6 axis.Penulis membuat prototype mesin mini CNC plotter 3 - axis dari bahan standar dengan software yangopensource sehingga seluruh masyarakat bisa mencoba mempelajari mesin CNC tersebut, adapun softwareyang akan digunakan sebagai kontrol dari mesin mini CNC plotter tersebut adalah GRBL Controller danjuga mesin ini menggabungkan software aplikasi inscape yang berguna sebagai converter menjadi GCode.Dalam penulisan penelitian ini metode penelitian yang digunakan penulis yaitu dengan melakukanmetode kuantitatif yang akan menjelaskan sistem dari software mesin mini CNC plotter 3 - axis sehinggamenjadi satu kesatuan sistem yang akan dijelaskan dari data - data G-Code yang sudah dibuat.
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Law, Che-Leung, Maria K. Ewings, Preet M. Chaudhary, Sasha A. Solow, Theodore J. Yun, Aaron J. Marshall, Leroy Hood, and Edward A. Clark. "GrpL, a Grb2-related Adaptor Protein, Interacts with SLP-76 to Regulate Nuclear Factor of Activated T Cell Activation." Journal of Experimental Medicine 189, no. 8 (April 19, 1999): 1243–53. http://dx.doi.org/10.1084/jem.189.8.1243.

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Propagation of signals from the T cell antigen receptor (TCR) involves a number of adaptor molecules. SH2 domain–containing protein 76 (SLP-76) interacts with the guanine nucleotide exchange factor Vav to activate the nuclear factor of activated cells (NF-AT), and its expression is required for normal T cell development. We report the cloning and characterization of a novel Grb2-like adaptor molecule designated as Grb2-related protein of the lymphoid system (GrpL). Expression of GrpL is restricted to hematopoietic tissues, and it is distinguished from Grb2 by having a proline-rich region. GrpL can be coimmunoprecipitated with SLP-76 but not with Sos1 or Sos2 from Jurkat cell lysates. In contrast, Grb2 can be coimmunoprecipitated with Sos1 and Sos2 but not with SLP-76. Moreover, tyrosine-phosphorylated LAT/pp36/38 in detergent lysates prepared from anti-CD3 stimulated T cells associated with Grb2 but not GrpL. These data reveal the presence of distinct complexes involving GrpL and Grb2 in T cells. A functional role of the GrpL–SLP-76 complex is suggested by the ability of GrpL to act alone or in concert with SLP-76 to augment NF-AT activation in Jurkat T cells.
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Bohm, Andrew. "AMi: a GUI-based, open-source system for imaging samples in multi-well plates." Acta Crystallographica Section F Structural Biology Communications 75, no. 8 (August 1, 2019): 531–36. http://dx.doi.org/10.1107/s2053230x19009853.

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Described here are instructions for building and using an inexpensive automated microscope (AMi) that has been specifically designed for viewing and imaging the contents of multi-well plates. The X, Y, Z translation stage is controlled through dedicated software (AMiGUI) that is being made freely available. Movements are controlled by an Arduino-based board running grbl, and the graphical user interface and image acquisition are controlled via a Raspberry Pi microcomputer running Python. Images can be written to the Raspberry Pi or to a remote disk. Plates with multiple sample wells at each row/column position are supported, and a script file for automated z-stack depth-of-field enhancement is written along with the images. The graphical user interface and real-time imaging also make it easy to manually inspect and capture images of individual samples.
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Santoso, Andhik Budi, Didik Riyanto, and Gus Nanang Syaifuddin. "Rancang Bangun Alat Batik Kulit Kepala Harimau Barongan Reyog Ponorogo Menggunakan Arduino." TELKA - Telekomunikasi Elektronika Komputasi dan Kontrol 7, no. 1 (May 24, 2021): 11–20. http://dx.doi.org/10.15575/telka.v7n1.11-20.

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Ponorogo identik dengan kesenian dan kerajinan reyog, salah satunya adalah topeng Barongan. Material utama topeng Barongan adalah kayu dadap sebagai kerangka utama dan kulit harimau sebagai pelapis luarnya. Perburuan harimau dilarang keras dalam rangka konservasi satwa langka, sehingga memaksa pengrajin topeng Barongan mencari alternatif lain, salah satunya menggunakan kulit sapi yang diberi pola khas harimau. Namun teknik yang digunakan masih manual sehingga memerlukan ketelitian, ketekunan dan waktu yang relatif lama. Maka dalam penelitian ini dibuat alat batik kulit kepala harimau Barongan Reyog Ponorogo. Gerakan alat batik kulit Barongan diatur oleh G-Code dan diinput melalui Software Grbl sender. Arduino berfungsi sebagai kontroler yang selanjutnya dapat menggerakkan motor Stepper sebagai penggerak sumbu dan Solenoid sebagai penekan penbrush untuk pewarnaan. Hasil penelitian ini menunjukkan alat batik Barongan Reyog Ponorogo mampu membuat pola harimau pada ukuran 30 x 35 cm dan memiliki kualitas yang hampir sama dengan teknik manual dengan waktu pewarnaan 8 menit. Ponorogo has been famous for its Reyog arts and crafts, one of them is the Barongan mask. The main materials for the Barongan mask are Dadap wood as the mainframe and tiger leather as the outer coating. Tiger hunting is strictly prohibited in the context of the conservation of endangered species. To force the Barongan mask craftsmen for other alternatives, one of the alternatives is to use cow leather which is drawn with a typical tiger pattern. However, the technique used is still manual, meanwhile, the manual technique requires a lot of precision, persistence, and time. So the research aim is to design and implement the tool for drawing the Barongan tiger's scalp on Reyog Ponorogo. The movement of the Barongan leather batik tool was regulated by G-Code and input via the Grbl sender Software then accepted by Arduino as a controller which can then move the Stepper motor as an axis drive and the Solenoid as a pen brush press for coloring. The results of this study indicate that the Barongan Reyog Ponorogo batik tool can make a tiger pattern at a size of 30 x 35 cm and almost has the same quality as the manual technique with a coloring time of 8 minutes.
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MichałowskI, Michał J., Dong Xu, Jamie Stevens, Andrew Levan, Jun Yang, Zsolt Paragi, Atish Kamble, et al. "The second-closest gamma-ray burst: sub-luminous GRB 111005A with no supernova in a super-solar metallicity environment." Astronomy & Astrophysics 616 (August 2018): A169. http://dx.doi.org/10.1051/0004-6361/201629942.

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We report the detection of the radio afterglow of a long gamma-ray burst (GRB) 111005A at 5-345 GHz, including very long baseline interferometry observations with a positional error of 0.2 mas. The afterglow position is coincident with the disc of a galaxy ESO 58049 at z = 0.01326 (∼1″ from its centre), which makes GRB 111005A the second-closest GRB known to date, after GRB 980425. The radio afterglow of GRB 111005A was an order of magnitude less luminous than those of local low-luminosity GRBs, and obviously less luminous than those of cosmological GRBs. The radio flux was approximately constant and then experienced an unusually rapid decay a month after the GRB explosion. Similarly to only two other GRBs, we did not find the associated supernovae (SNe), despite deep near- and mid-infrared observations 1-9 days after the GRB explosion, reaching ∼20 times fainter than other SNe associated with GRBs. Moreover, we measured a twice-solar metallicity for the GRB location. The low y-ray and radio luminosities, rapid decay, lack of a SN, and super-solar metallicity suggest that GRB 111005A represents a rare class of GRB that is different from typical core-collapse events. We modelled the spectral energy distribution of the GRB 111005A host finding that it is a moderately star-forming dwarf galaxy, similar to the host of GRB 980425. The existence of two local GRBs in such galaxies is still consistent with the hypothesis that the GRB rate is proportional to the cosmic star formation rate (SFR) density, but suggests that the GRB rate is biased towards low SFRs. Using the far-infrared detection of ESO 580-49, we conclude that the hosts of both GRBs 111005A and 980425 exhibit lower dust content than what would be expected from their stellar masses and optical colors.
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Dissertations / Theses on the topic "GRBL"

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Chaňo, Patrik. "Hobby CNC frézka." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2020. http://www.nusl.cz/ntk/nusl-416606.

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This diploma thesis serves as a design and implementation of a hobby CNC milling machine, for the modeling community. The work is conceived as an overview of the most common machining technologies. The following is an introduction to the construction of CNC milling machines and an introduction to the basic components used. Furthermore, the actual design proposals and a description of the implementation of two of them are presented. When designing the machine, emphasis was placed on the lowest possible price and availability of individual components.
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Shimabukuro, Satoshi, Piero Diaz, and Leonardo Vinces. "Low cost semi-industrial 3GDL CNC vertical milling center design with non-ferrous metal machining capability." Institute of Electrical and Electronics Engineers Inc, 2020. http://hdl.handle.net/10757/656633.

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El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.
This work proposes the design of a low cost semi-industrial three degree of freedom CNC vertical milling center (VMC) with non-ferrous metal machining capabilities. The design seeks to mitigate the difficulties that acquiring a commercial industrial CNC can present, such as large dimensions, high cost and complications in its transportation within the plant. The proposed machine will be made up of 1 NEMA 23 stepper motor for each X, Y and Z axis, and will be controlled by open source firmware using an ATMEGA 2560 microcontroller. Likewise, the working area will be 320x180mm and will have a precision 100 microns with semi industrial capacities. This design is aimed at small and medium-sized companies that are looking for a low cost non-ferrous CNC milling machine that in turn has the quality, performance and precision of an industrial one.
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Stuchlý, Martin. "Návrh a realizace vrtačky na plošné spoje." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2021. http://www.nusl.cz/ntk/nusl-449717.

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This thesis is focused on proposing a design and providing the realisation of a CNC drill used for printed circuits. The first section is concerned with researching the background of CNC drills, which is followed by the proposed design and realisation of a custom model. Fundamental calculations and individual constructional aspects were carried out based on the chosen parameters. Furthermore, the operating electronic functions and the description of a G-code generating program is the main content of the second section. Finally, the last part of this thesis includes economic evaluation and the CNC drill’s assessment in practice.
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Pospíšil, Jiří. "Hobby CNC frézka." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2015. http://www.nusl.cz/ntk/nusl-232104.

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This diploma thesis serves as experimental proof of real world capabilities of computer designed hobby CNC milling machine with its parts printed on a 3D printer. First half is a brief introduction of CNC technologies to non-professional audience. Second part together with 3D model works as manual to build your own machine. Priority was to keep costs to minimum with decent accuracy still in mind.
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Blahút, Jozef. "Automatická expoziční jednotka pro výrobu DPS." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2017. http://www.nusl.cz/ntk/nusl-318637.

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This diploma thesis deals with the issue of fast high-quality prototype production of printed circuit boards for the needs of the mechatronics lab. Within the scope of this thesis a prototype machine was proposed and created together with control software, which by the help of DLP projector and two stage axis allows to produce printed circuit board in relatively short period of time.
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Sears, Huei M. "Investigation of the Mass-Metallicity Relation of GRB Host Galaxies at z ~ 4.7." Ohio University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1597762492071921.

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McDonald, Caleb Benton. "Physicochemical Studies of the Grb2-Sos1 Interaction." Scholarly Repository, 2009. http://scholarlyrepository.miami.edu/oa_dissertations/260.

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Grb2, a modular protein comprised of a central SH2 domain flanked between a N-terminal SH3 (nSH3) domain and a C-terminal SH3 (cSH3) domain, is a component of cell signaling networks involved in the transmission of extracellular information in the form of growth factors and cytokines to downstream targets such as transcription factors within the nucleus. The Grb2-Sos1 interaction is mediated through the combinatorial binding of nSH3 and cSH3 domains of Grb2 to various sites - designated S1, S2, S3, and S4 - containing PXpsiPXR motifs within Sos1. Here, using a diverse array of biophysical techniques, including in particular isothermal titration calorimetry coupled with molecular modeling and semi-empirical analysis, I provide new insights into the Grb2-Sos1 interaction in thermodynamic and structural terms. My data show that Grb2 exists in monomer-dimer equilibrium in solution and that the dissociation of dimer into monomers is entropically-driven. The heat capacity change observed was much smaller than that expected from the rather large molecular surfaces becoming solvent-occluded upon dimerization, implying that monomers undergo conformational rearrangement upon dimerization. 3D structural models suggest strongly that such conformational rearrangement may arise from domain swapping. I further show that the nSH3 domain of Grb2 binds to the S1 site containing the proline-rich consensus motif PXpsiPXR with an affinity that is nearly three-fold greater than that observed for the binding of the cSH3 domain. It is also demonstrated that such differential binding of the nSH3 domain relative to the cSH3 domain is largely due to the requirement of a specific acidic residue, in the RT loop, to engage in the formation of a salt bridge with the arginine residue in the consensus motif PXpsiPXR. The data further reveal that, while binding of both SH3 domains to Sos1 is under enthalpic control, the nSH3 binding suffers from entropic penalty in contrast to entropic gain accompanying the binding of cSH3, implying that the two domains employ differential thermodynamic mechanisms for Sos1 recognition. Additionally, my data reveal that while the nSH3 domain of Grb2 binds with affinities in the physiological range to all four sites S1-S4, the cSH3 domain can only do so at the S1 site. Further scrutiny of these sites yields rationale for the recognition of various PXpsiPXR motifs by the SH3 domains in a discriminate manner. Unlike the PXpsiPXR motifs at S2, S3 and S4 sites, the PXpsiPXR motif at S1 site is flanked at its C-terminus with two additional arginine residues that are absolutely required for high-affinity binding of the cSH3 domain. In contrast, these two additional arginine residues augment the binding of the nSH3 domain to the S1 site but their role is not critical for the recognition of S2, S3 and S4 sites. Molecular modeling is employed to rationalize my new findings in structural terms. Taken together, this thesis provides novel insights into the physicochemical basis of a key protein-protein interaction pertinent to cellular signaling and cancer. My studies bear the potential for the development of novel therapies with less toxicity but more effectiveness for the treatment of disease.
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Albrecht, Sebastian. "Multivariate GRBF-Netzwerke und Systeme lokaler Experten." Diss., lmu, 2000. http://nbn-resolving.de/urn:nbn:de:bvb:19-1248.

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Su, Vi-Minh-Tri. "The role of Grb2 in HER2-mediates tumourigenesis." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110360.

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Grb2, an adaptor protein, is ubiquitously expressed and is involved in mediating a multitude of cellular processes in various body tissues such as development and tumourigenesis. Grb2 binds to proteins via its Src-homology domains and by doing so brings them in proximity of each other. In breast tissue, Grb2 can recruit SOS and Gab1 to the plasma membrane by binding to a specific phosphorylated tyrosine residue of HER2, a member of the epidermal growth factor receptor family. HER2 is overexpressed and activated in 20-30% of human breast cancers and correlates with poor patient prognosis. In transgenic mouse models, activated Neu, a rat analog of HER2, has shown the ability to induce mammary tumours. Given that Grb2 is a link between HER2 and tumourigenic signaling pathways, the goal of the current study was to investigate how loss of Grb2 expression affects mammary gland development and mammary tumourigenesis using a conditional Grb2 mouse model. Differences in protein expression, ductal outgrowth, delay in tumour onset, metastasis to the lung were some of the measurements taken to evaluate the role of Grb2. Also, parallel in-vivo experiments were conducted by using shRNA construct targeted to Grb2 in mammary gland tumour-derived cell lines. As expected, it was uncovered that Grb2 is required for normal mammary gland development and mammary tumour initiation in a HER2-induced mammary tumour mouse model but its mechanism of action has yet to be elucidated.
Growth factor receptor bound protein 2(Grb2) est une protéine adaptatrice, exprimée demanière ubiquitaire, qui joue un rôle important dans une multitude de processus cellulaires tels que le développement mammaire et la genèse de tumeurs mammaires. Grb2 regroupe diverses protéines grâce à ses domaines d'homologie Src afin de permettre leur interaction. Dans les tissues mammaires, Grb2 peut recruter SOS et Gab1 à la membrane plasmique en se liant à une tyrosine spécifique, phosphorylée et localisée sur HER2, un membre de la famille des récepteurs du facteur de croissance épidermique. HER2 est sur exprimé et activé dans 20-30% des cancers du sein et est lié à un mauvais pronostic chez le patient. Plusieurs études effectuées à partir de modèles de souris transgéniques, ont démontrées la capacité d'ErbB2, l'analogue d'HER2 chez la souris, à induire des tumeurs mammaires. L'objectif de ma recherche est d'étudier les conséquences de l'ablation fonctionnelle et spécifique de Grb2. Un modèle de souris avec un knock-out spécifique de Grb2 au niveau des glandes mammaires permet d'étudier le rôle distinctif de la protéine dans le cadre de la genèse des tumeurs mammaires. Les différences au niveau de l'expression protéique de Grb2, la longueur des canaux lactifères, le délai au niveau de l'apparition de tumeurs et les métastases aux poumons détectés chez l'animal représentent quelques-uns des paramètres évalués afin de déterminer l'importance de Grb2 dans le développement des tumeurs mammaires. Parallèlement, des expériences in vitro tel l'utilisation de constructions shRNA ciblant l'ARN messager de Grb2 introduits dans une lignée cellulaire dérivée d'une tumeur de la glande mammaire, permettent d'élaborer sur le rôle de la protéine d'intérêt dans le développement des tumeurs mammaires.
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10

Laskar, Tanmoy, Kate D. Alexander, Edo Berger, Wen-fai Fong, Raffaella Margutti, Isaac Shivvers, Peter K. G. Williams, et al. "A REVERSE SHOCK IN GRB 160509A." IOP PUBLISHING LTD, 2016. http://hdl.handle.net/10150/624020.

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We present the second multi-frequency radio detection of a reverse shock in a gamma-ray burst. By combining our extensive radio observations of the Fermi-Large Area Telescope gamma-ray burst 160509A at z - 1.17 up to 20 days after the burst with Swift X-ray observations and ground-based optical and near-infrared data, we show that the afterglow emission comprises distinct reverse shock and forward shock contributions: the reverse shock emission dominates in the radio band at. less than or similar to 10 days, while the forward shock emission dominates in the X-ray, optical, and near-infrared bands. Through multi-wavelength modeling, we determine a circumburst density of n(0) approximate to 10(-3) cm(-3), supporting our previous suggestion that a low- density circumburst environment is conducive to the production of long-lasting reverse shock radiation in the radio band. We infer the presence of a large excess X-ray absorption column, N-H approximate to 1.5. x 10(22) cm(-2), and a high rest-frame optical extinction, A(V) approximate to 3.4 mag. We identify a jet break in the X-ray light curve at t(jet) approximate to 6 days, and thus derive a jet opening angle of theta(jet) approximate to 4 degrees, yielding a beaming-corrected kinetic energy and radiated gamma-ray energy of E-K approximate to 4 x 10(50) erg and E-gamma approximate to 1.3 x 10(51) erg ( 1-10(4) keV, rest frame), respectively. Consistency arguments connecting the forward shocks and reverse shocks suggest a deceleration time of t(dec) approximate to 460 s approximate to T-90, a Lorentz factor of Gamma( t(dec)) approximate to 330, and a reverse-shock-to-forward-shock fractional magnetic energy density ratio of R-B equivalent to is an element of(B, RS)/is an element of(B, FS) approximate to 8. Our study highlights the power of rapid-response radio observations in the study of the properties and dynamics of gamma-ray burst ejecta.
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Books on the topic "GRBL"

1

Pazinski grb: Postanak i razvitak grba grada Pazina. Pazin: vlast. nakl., 2006.

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Gral. Zagreb: Nakladni zavod Matice hrvatske, 1994.

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Grübl, Manfred. Manfred Grübl. [Wien: Triton, 2002.

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Kharal, Nasīm. Miksḍ gril. Virginia, USA: Vicār Pablīsharz, 2008.

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Miḳsi Gril. Tel-Aviv: Yediʻot aḥaronot, 2005.

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Mahfood, Jim. Grrl scouts. Portland, OR: Oni Press, 2000.

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Čaldarović, Dubravka Peić. Povijest hrvatskoga grba: Hrvatski grb u mijenama hrvatske povijesti od 14. do početka 21. stoljeća. Zagreb: Školska knjiga, 2011.

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Little (grrl) lost. New York, N.Y: Viking, 2007.

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Daraize, Thierry. Sur le gril. Outremont, Québec: Trécarré, 2001.

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Faraut, Jacques. Calcul inte gral. Les Ulis, France: EDP Sciences, 2006.

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Book chapters on the topic "GRBL"

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Roch, Eckhard. "Der Gral." In Psychodrama, 357–404. Stuttgart: J.B. Metzler, 1995. http://dx.doi.org/10.1007/978-3-476-03571-4_12.

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Kane, Yukari Iwatani, and Pauline Kurbasik. "Der heilige Gral." In Das wankende Imperium, 327–41. München: Carl Hanser Verlag GmbH & Co. KG, 2015. http://dx.doi.org/10.3139/9783446436442.018.

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Herrmann-Pfandt, Adelheid. "Bar do thos grol." In Kindlers Literatur Lexikon (KLL), 1–2. Stuttgart: J.B. Metzler, 2020. http://dx.doi.org/10.1007/978-3-476-05728-0_4731-1.

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Petitjean, Patrick, F. Y. Wang, X. F. Wu, and J. J. Wei. "GRBs and Fundamental Physics." In Gamma-Ray Bursts, 197–236. Dordrecht: Springer Netherlands, 2016. http://dx.doi.org/10.1007/978-94-024-1279-6_9.

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Nadis, Steve. "Der allgegenwärtige Heilige Gral." In Der Einfluß von Erdnußbutter auf die Erdrotation — Forschungen, die die Welt nicht braucht, 81–84. Basel: Birkhäuser Basel, 1999. http://dx.doi.org/10.1007/978-3-0348-6244-8_22.

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Zhang, Bing, Hou-Jun Lü, and En-Wei Liang. "GRB Observational Properties." In Gamma-Ray Bursts, 5–34. Dordrecht: Springer Netherlands, 2016. http://dx.doi.org/10.1007/978-94-024-1279-6_2.

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Berti, Guntram. "GrAL- The Grid Algorithms Library." In Lecture Notes in Computer Science, 745–54. Berlin, Heidelberg: Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/3-540-47789-6_77.

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Sauer, Roman, Martina Dopfer, Jessica Schmeiss, and Oliver Gassmann. "Das Geschäftsmodell: Gral der Digitalisierung." In Digitale Transformation gestalten, 19–32. München: Carl Hanser Verlag GmbH & Co. KG, 2019. http://dx.doi.org/10.3139/9783446459632.002.

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Sauer, Roman, Martina Dopfer, Jessica Schmeiss, and Oliver Gassmann. "Geschäftsmodell als Gral der Digitalisierung." In Digitale Transformation im Unternehmen gestalten, 15–27. München: Carl Hanser Verlag GmbH & Co. KG, 2016. http://dx.doi.org/10.3139/9783446451148.002.

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Mesler, Robert Allan. "Calorimetry of GRB 030329." In Searching for the Long-Duration Gamma-Ray Burst Progenitor, 87–98. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-06626-4_5.

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Conference papers on the topic "GRBL"

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Sarguroh, Sakib Shaukat, and Arun Bhiva Rane. "Using GRBL-Arduino-based controller to run a two-axis computerized numerical control machine." In 2018 International Conference on Smart City and Emerging Technology (ICSCET). IEEE, 2018. http://dx.doi.org/10.1109/icscet.2018.8537315.

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Wang, Fayin. "GRB Cosmology and SOC in GRBs." In Swift: 10 Years of Discovery. Trieste, Italy: Sissa Medialab, 2015. http://dx.doi.org/10.22323/1.233.0116.

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Wang, F. Y., Z. G. Dai, Yong-Feng Huang, Zi-Gao Dai, and Bing Zhang. "Recent progress on GRB cosmology: cosmography using GRBs." In 2008 NANJING GAMMA-RAY BURST CONFERENCE. AIP, 2008. http://dx.doi.org/10.1063/1.3027950.

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Sakamoto, T., S. Barthelmy, W. Baumgartner, J. Cummings, E. Fenimore, N. Gehrels, H. Krimm, et al. "BAT2 GRB Catalog—Prompt Emission Properties of Swift GRBs—." In DECIPHERING THE ANCIENT UNIVERSE WITH GAMMA-RAY BURSTS. AIP, 2010. http://dx.doi.org/10.1063/1.3509266.

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Gendre, B., A. Klotz, E. Palazzi, T. Krühler, S. Covino, P. Afonso, L. A. Antonelli, et al. "The Standard Model of GRBs at Face with GRB 090102A." In DECIPHERING THE ANCIENT UNIVERSE WITH GAMMA-RAY BURSTS. AIP, 2010. http://dx.doi.org/10.1063/1.3509295.

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Del Monte, E., G. Barbiellini, F. Fuschino, A. Giuliani, F. Longo, M. Marisaldi, E. Moretti, et al. "The observation of GRBs with AGILE and the interesting cases of GRB 090618 and GRB 100724B." In GAMMA RAY BURSTS 2010. AIP, 2011. http://dx.doi.org/10.1063/1.3621773.

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Dai, Z. G., F. Y. Wang, Ye-Fei Yuan, Xiang-Dong Li, and Dong Lai. "Recent progress in GRB cosmology: combination of GRBs and other probes." In ASTROPHYSICS OF COMPACT OBJECTS: International Conference on Astrophysics of Compact Objects. AIP, 2008. http://dx.doi.org/10.1063/1.2840394.

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Nagataki, Shigehiro, Nobuyuki Kawai, and Shigehiro Nagataki. "GRB-SN Connection: Central Engine of Long GRBs and Explosive Nucleosynthesis." In DECIPHERING THE ANCIENT UNIVERSE WITH GAMMA-RAY BURSTS. AIP, 2010. http://dx.doi.org/10.1063/1.3509356.

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DAINOTTI, MARIA GIOVANNA, MARIA GRAZIA BERNARDINI, BIANCO CARLO BIANCOW, LETIZIA CAITO, ROBERTO GUIDA, and REMO RUFFINI. "ON GRB 060218 AND THE GRBs RELATED TO SUPERNOVAE Ib/c." In Proceedings of the MG11 Meeting on General Relativity. World Scientific Publishing Company, 2008. http://dx.doi.org/10.1142/9789812834300_0304.

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Jakobsson, P. "GRB 050814 at z = 5.3 and the Redshift Distribution of Swift GRBs." In GAMMA-RAY BURSTS IN THE SWIFT ERA: Sixteenth Maryland Astrophysics Conference. AIP, 2006. http://dx.doi.org/10.1063/1.2207953.

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Reports on the topic "GRBL"

1

Dermer, Charles D. First Light on GRBs with Fermi. Fort Belvoir, VA: Defense Technical Information Center, August 2010. http://dx.doi.org/10.21236/ada526017.

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Soderberg, A. The Sub-Energetic GRB 031203 as a Cosmic Analogue to GRB 980425. Office of Scientific and Technical Information (OSTI), August 2004. http://dx.doi.org/10.2172/829715.

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Yang, Dajun. Testing Grb2 as a Target for Cancer Therapy. Fort Belvoir, VA: Defense Technical Information Center, August 2000. http://dx.doi.org/10.21236/ada398194.

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Yang, Dajun. Testing Grb2 as a Target for Cancer Therapy. Fort Belvoir, VA: Defense Technical Information Center, August 2001. http://dx.doi.org/10.21236/ada405163.

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Gillette, Jarred. Characterizing high-energy light curves of Fermi/Lat GRBs. Office of Scientific and Technical Information (OSTI), August 2015. http://dx.doi.org/10.2172/1213160.

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Ramirez-Ruiz, E. An Off-Axis Model for GRB 031203. Office of Scientific and Technical Information (OSTI), January 2005. http://dx.doi.org/10.2172/839637.

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Dermer, C. GRBs as Ultra-High Energy Cosmic Ray Sources: Clues From Fermi. Fort Belvoir, VA: Defense Technical Information Center, March 2010. http://dx.doi.org/10.21236/ada522743.

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Granot, Jonathan, Arieh Konigl, and Tsvi Piran. Implications of the Early X-Ray Afterglow Light Curves of Swift GRBs. Office of Scientific and Technical Information (OSTI), January 2006. http://dx.doi.org/10.2172/877982.

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Winkles, Jeffrey A. GrB-TWEAK: A Potential Novel Biologic for NSCLC Therapy. Fort Belvoir, VA: Defense Technical Information Center, September 2015. http://dx.doi.org/10.21236/ada624531.

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Granot, J. Radio Flares and the Magnetic Field Structure in GRB Outflows. Office of Scientific and Technical Information (OSTI), January 2005. http://dx.doi.org/10.2172/839636.

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