Relevant bibliographies by topics / GRDDL

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'GRDDL'

Author: Grafiati
Published: 4 June 2021
Last updated: 18 February 2022

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Journal articles on the topic "GRDDL"

1

Annisa, Viviane. "Review of Gastroretentive Drug Delivery System (GRDDS)." Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan 7, no. 1 (April 22, 2021): 1. http://dx.doi.org/10.33772/pharmauho.v7i1.11693.

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Penghantaran obat oral memiliki keterbatasan terkait dengan absorpsi pada saluran pencernaan yang tidak sempurna. Absorpsi yang tidak sempurna ini dapat mempengaruhi tercapainya dosis terapi. Hal ini dipengaruhi oleh lambung karena adanya faktor Gastro Residence Time (GRT). Untuk meningkatkan absorpsi obat pada lambung, maka memerlukan sistem penghantaran obat yang dapat memperlama GRT. Salah satu penghantaran obat yang dapat memperlama GRT adalah Gastroretentive Drug Delivery System (GRDDS). Pengembangan GRDDS memiliki banyak keuntungan, seperti meningkatkan bioavailabilitas obat, meningkatkan kelarutan obat yang kurang larut dalam pH tinggi, dapat mengontrol level terapi sehingga mengurangi terjadinya fluktuasi, serta dapat memperpanjang waktu paruh sehingga frekuensi pemberian obat dapat dikurangi. Faktor yang dapat mempengaruhi formulasi GRDDS adalah faktor farmasetika, fisiologis, dan kondisi pasien. Terdapat beberapa sistem dalam formulasi GRDDS, seperti sistem floating, bioadesif, densitas tinggi, superporos, expandable, raft forming, dan magnetik. Sistem floating dapat melalui 2 mekanisme pembuatan, yakni secara effervescent dan non-effervescent. Telah banyak bentuk sediaan dengan sistem GRDDS yang diproduksi dalam skala industri sehingga dapat ditemukan di pasaran.
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Tripathi, Thapa, Maharjan, and Jeong. "Current State and Future Perspectives on Gastroretentive Drug Delivery Systems." Pharmaceutics 11, no. 4 (April 20, 2019): 193. http://dx.doi.org/10.3390/pharmaceutics11040193.

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In recent years, many attempts have been made to enhance the drug bioavailability and therapeutic effectiveness of oral dosage forms. In this context, various gastroretentive drug delivery systems (GRDDS) have been used to improve the therapeutic efficacy of drugs that have a narrow absorption window, are unstable at alkaline pH, are soluble in acidic conditions, and are active locally in the stomach. In this review, we discuss the physiological state of the stomach and various factors that affect GRDDS. Recently applied gastrointestinal technologies such as expandable, superporous hydrogel; bio/mucoadhesive, magnetic, ion-exchange resin; and low- and high-density-systems have also been examined along with their merits and demerits. The significance of in vitro and in vivo evaluation parameters of various GRDDS is summarized along with their applications. Moreover, future perspectives on this technology are discussed to minimize the gastric emptying rate in both the fasted and fed states. Overall, this review may inform and guide formulation scientists in designing the GRDDS.
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v. Heyden. "Ueber Rhagonycha rhaetica Stierl. u. Scopolii Gredl." Berliner entomologische Zeitschrift 24, no. 1 (April 18, 2008): 227. http://dx.doi.org/10.1002/mmnd.18800240126.

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Durga Srinivasarao M, Saravanakumar K., and Chandra Sekhar Kothapalli Bannoth. "Gastro-retentive drug delivery systems: a review with focus on ϐloating drug delivery systems." International Journal of Research in Pharmaceutical Sciences 12, no. 2 (May 1, 2021): 1330–37. http://dx.doi.org/10.26452/ijrps.v12i2.4684.

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Gastro-retentive drug delivery systems (GRDDS) attributes to gastric maintenance time combined with the medication discharge for expanded time has essentially improved patient consistency. Medications for which the chief fundamental site of ingestion is the stomach or the proximal piece of the small digestive tract or have the assimilation issue in the distal piece of the digestive system are reasonable for GRDDS. Orally sustaining or controlling the drug release combined with gastric retention property can avoid recurrent dosing in the case of drugs with short half-lives. GRDDS is also effective in locally treating gastric and duodenal ulcers, including oesophagitis and Helicobacter pylori infections. In this current survey, the physiology of the stomach alongside its motility design, typically called migrating motor complex (MMC), was discussed. Various approaches to GRDDS with a focus on floating drug delivery systems (FDDS) were reviewed. The vacillations in plasma drug focus are limited and portion subordinate unfriendly impacts can be forestalled by FDDS, particularly for the medications with a restricted restorative list. Slow arrival of the medication into the body by means of FDDS limits the counter movement prompting higher medication proficiency. Further, the Advantages, limitations, suitable drug candidates, factors affecting and Future challenges of FDDS were discussed.
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Birajdar, Anuradha A., Madhuri T. Deshmukh, and Rajkumar V. Shete. "A Review on Gastro-Retentive Floating Microspheres." Journal of Drug Delivery and Therapeutics 11, no. 1-s (February 15, 2021): 131–38. http://dx.doi.org/10.22270/jddt.v11i1-s.4518.

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The floating microsphere's purpose is to improve gastric retention time. Floating drug delivery systems are lower in bulk thickness than gastric juice and remain floating on gastric juice for a long period of time without impacting the gastric-emptying rate and increasing bioavailability. Gastro-retentive microspheres are particularly suitable for the continuous or late release of oral formulations with blending versatility to achieve various release patterns, low dose risk as a reproducible and short gastric retention time. The aim of this review is to address literature on the floating device, techniques, selection of suitable or inappropriate drug candidates for GRDDS, low density polymers used to swim over gastric fluid, processes, and floating microsphere assessment and application. Keywords: GRDDS, Floating system, Approaches, Polymer, Mechanism, Methods
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Lin, Hong-Liang, Ling-Chun Chen, Wen-Ting Cheng, Wei-Jie Cheng, Hsiu-O. Ho, and Ming-Thau Sheu. "Preparation and Characterization of a Novel Swellable and Floating Gastroretentive Drug Delivery System (sfGRDDS) for Enhanced Oral Bioavailability of Nilotinib." Pharmaceutics 12, no. 2 (February 6, 2020): 137. http://dx.doi.org/10.3390/pharmaceutics12020137.

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Regarding compliance and minimization of side effects of nilotinib therapy, there is a medical need to have a gastroretentive drug delivery system (GRDDS) to enhance the oral bioavailability that is able to administer an optimal dose in a quaque die (QD) or daily manner. In this study, the influence on a swelling and floating (sf) GRDDS composed of a polymeric excipient (HPMC 90SH 100K, HEC 250HHX, or PEO 7000K) and Kollidon® SR was examined. Results demonstrated that PEO 7000K/Kollidon SR (P/K) at a 7/3 ratio was determined to be a basic GRDDS formulation with optimal swelling and floating abilities. MCC PH102 or HPCsssl,SFP was further added at a 50% content to this basic formulation to increase the tablet hardness and release all of the drug within 24 h. Also, the caplet form and capsule form containing the same formulation demonstrated higher hardness for the former and enhanced floating ability for the latter. A pharmacokinetic study on rabbits with pH values in stomach and intestine similar to human confirmed that the enhanced oral bioavailability ranged from 2.65–8.39-fold with respect to Tasigna, a commercially available form of nilotinib. In conclusion, the multiple of enhancement of the oral bioavailability of nilotinib with sfGRDDS could offer a pharmacokinetic profile with therapeutic effectiveness for the QD administration of a reasonable dose of nilotinib, thereby increasing compliance and minimizing side effects.
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Kim, Hyeongmin, Chung-Lyol Lee, Seohyun Lee, Tae Jin Lee, Iqra Haleem, Younghong Lee, Na Jung Hwang, Kyusun Shim, Dohyun Kim, and Jaehwi Lee. "Mechanically Robust Gastroretentive Drug-Delivery Systems Capable of Controlling Dissolution Behaviors of Coground β-Lapachone." Pharmaceutics 11, no. 6 (June 10, 2019): 271. http://dx.doi.org/10.3390/pharmaceutics11060271.

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In this study, we aimed to design a highly swellable and mechanically robust matrix tablet (SMT) as a gastroretentive drug-delivery system (GRDDS) capable of improving the dissolution behavior of β-lapachone with low aqueous solubility. For the preparation of SMTs, the cogrinding technique and freeze–thaw method were used to disperse β-lapachone in SMTs in an amorphous state and to enhance the swelling and mechanical properties of SMTs, respectively. As a result, the crystallinity of coground β-lapachone incorporated in the SMTs was found to be considerably decreased; thereby, the dissolution rates of the drug in a simulated gastric fluid could be substantially increased. The SMTs of β-lapachone also demonstrated significantly enhanced swelling and mechanical properties compared to those of a marketed product. The reason for this might be because the physically crosslinked polymeric networks with a porous structure that were formed in SMTs through the freeze–thaw method. In addition, β-lapachone was gradually released from the SMTs in 6 h. Therefore, SMTs of β-lapachone developed in this study could be used as GRDDS with appropriate swelling and mechanical properties for improving the dissolution behavior of hydrophobic drugs such as β-lapachone.
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Matharu, Amol S., Michael G. Motto, Mahendra R. Patel, Anthony P. Simonelli, and Rutesh H. Dave. "Evaluation of Hydroxypropyl Methylcellulose Matrix Systems as Swellable Gastro-Retentive Drug Delivery Systems (GRDDS)." Journal of Pharmaceutical Sciences 100, no. 1 (January 2011): 150–63. http://dx.doi.org/10.1002/jps.22252.

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Kurrer, Karl-Eugen. "Ignaz Gridl. Eisenkonstruktionen. Ingenieurbaukunst und Innovation im späten 19. Jahrhundert. Fotografien von Nora Schoeller. Von Fogarassy, A." Stahlbau 82, no. 3 (March 2013): 228–29. http://dx.doi.org/10.1002/stab.201390037.

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Raghu Kiran, Chintalapati V. S., and Chakka Gopinath. "Development and evaluation of interpenetrating polymer network based superporous hydrogel gastroretentive drug delivery systems (SPH IPN-GRDDS)." Materials Today: Proceedings 46 (2021): 3056–61. http://dx.doi.org/10.1016/j.matpr.2021.02.381.

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Dissertations / Theses on the topic "GRDDL"

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Langer, André. "SemProj: Ein Semantic Web – basiertes System zur Unterstützung von Workflow- und Projektmanagement." Master's thesis, Universitätsbibliothek Chemnitz, 2008. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-200800307.

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Mit mehr als 120 Millionen registrierten Internetadressen (Stand: März 2007) symbolisiert das Internet heutzutage das größte Informationsmedium unserer Zeit. Täglich wächst das Internet um eine unüberschaubare Menge an Informationen. Diese Informationen sind häufig in Dokumenten hinterlegt, welche zur Auszeichnung die Hypertext Markup Language verwenden. Seit Beginn der Neunziger Jahre hat sich dieses System bewährt, da dadurch der einzelne Nutzer in die Lage versetzt wird, auf einfache und effiziente Weise Dokumentinhalte mit Darstellungsanweisungen zu versehen und diese eigenständig im Internet zu veröffentlichen. Diese Layoutinformationen können bei Abruf der entsprechenden Ressource durch ein Computerprogramm leicht ausgewertet und zur Darstellung der Inhalte genutzt werden. Obwohl sowohl die Layoutinformationen als auch die eigentlichen Dokumentinhalte in einem textuellen Format vorliegen, konnten die Nutzertextinhalte durch eine Maschine bisher nur sehr eingeschränkt verarbeitet werden. Während es menschlichen Nutzern keinerlei Probleme bereitet, die Bedeutung einzelner Texte auf einer Webseite zu identifizieren, stellen diese für einen Rechner prinzipiell nur eine Aneinanderreihung von ASCII-Zeichen dar. Sobald es möglich werden würde, die Bedeutung von Informationen durch ein Computerprogramm effizient zu erfassen und weiterzuverarbeiten, wären völlig neue Anwendungen mit qualitativ hochwertigeren Ergebnissen im weltweiten Datennetz möglich. Nutzer könnten Anfragen an spezielle Agenten stellen, welche sich selbstständig auf die Suche nach passenden Resultaten begeben; Informationen verschiedener Informationsquellen könnten nicht nur auf semantischer Ebene verknüpft, sondern daraus sogar neue, nicht explizit enthaltene Informationen abgeleitet werden. Ansätze dazu, wie Dokumente mit semantischen Metadaten versehen werden können, gibt es bereits seit einiger Zeit. Lange umfasste dies jedoch die redundante Bereitstellung der Informationen in einem eigenen Dokumentenformat, weswegen sich keines der Konzepte bis in den Privatbereich durchsetzen konnte und als Endkonsequenz in den vergangenen Monaten besonderes Forschungsinteresse darin aufkam, Möglichkeiten zu finden, wie semantische Informationen ohne großen Zusatzaufwand direkt in bestehende HTML-Dokumente eingebettet werden können. Die vorliegende Diplomarbeit möchte diese neuen Möglichkeiten im Bereich des kollaborativen Arbeitens näher untersuchen. Ziel ist es dazu, eine Webapplikation zur Abwicklung typischer Projektmanagement-Aufgaben zu entwickeln, welche jegliche Informationen unter einem semantischen Gesichtspunkt analysieren, aufbereiten und weiterverarbeiten kann und unabhängig von der konkreten Anwendungsdomain und Plattform systemübergreifend eingesetzt werden kann. Die Konzepte Microformats und RDFa werden dabei besonders herausgestellt und nach Schwächen und zukünftigen Potentialen hin untersucht
The World Wide Web supposably symbolizes with currently more than 120 million registered internet domains (March 2007) the most comprehensive information reference of all times. The amount of information available increases by a storming bulk of data ever day. Those information is often embedded in documents which utilize the Hypertext Markup Language. This enables the user to mark out certain layout properties of a text in an easy and efficient fashion and to publish the final document containing both layout and data information. A computer application is then able to extract style information from the document resource and to use it in order to render the resulting website. Although layout information and data are both equally represented in a textual manner, a machine was hardly capable of processing user content so far. Whereas human consumers have no problem to identify and understand the sense of several paragraphs on a website, they basically represent only a concatenation of ASCII characters for a machine. If it were possible to efficiently disclose the sense of a word or phrase to a computer program in order to process it, new astounding applications with output results of high quality would be possible. Users could create queries for specialized agents which autonomously start to search the web for adequate result matches. Moreover, the data of multiple information sources could be linked and processed together on a semantic level so that above all new, not explicitly stated information could be inferred. Approaches already exist, how documents could be enhanced with semantic metadata, however, many of these involve the redundant provision of those information in a specialized document format. As a consequence none of these concepts succeeded in becoming a widely used method and research started again to find possibilities how to embed semantic annotations without huge additional efforts in an ordinary HTML document. The present thesis focuses on an analysis of these new concepts and possibilities in the area of collaborative work. The objective is to develop the prototype of a web application with which it is possible to manage typical challenges in the realm of project and workflow management. Any information available should be processable under a semantic viewpoint which includes analysis, conditioning and reuse independently from a specific application domain and a certain system platform. Microformats and RDFa are two of those relatively new concepts which enable an application to extract semantic information from a document resource and are therefore particularly exposed and compared with respect to advantages and disadvantages in the context of a “Semantic Web”
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Grödl, Felix Veit [Verfasser]. "Simulationstool zur Auslegung transkutaner Energieübertragungssysteme / Felix Veit Grödl." Aachen : Shaker, 2013. http://d-nb.info/1050343042/34.

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Grödl, Felix [Verfasser]. "Simulationstool zur Auslegung transkutaner Energieübertragungssysteme / Felix Veit Grödl." Aachen : Shaker, 2013. http://nbn-resolving.de/urn:nbn:de:101:1-201404275377.

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Čekan, Ondřej. "Systém pro správu obsahu založený na ontologiích." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2013. http://www.nusl.cz/ntk/nusl-236228.

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This thesis deals with the analysis, design and implementation of a system based on semantic technologies and ontology languages. There is described the semantic web and its concept, technology of semantic web especially RDF and OWL and the ability to view on the Web. Another part of this work treats with the specification, analysis, design actual implementation of the system, which processes the ontology and allows users to create individual depending on the definition of the ontology. The created content is presented on the Web annotated. The result of this work is the demonstration application.
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Gradl, Christian [Verfasser], and Christian [Akademischer Betreuer] Schüller. "Anisotrope Lochspindynamik in GaAs/AlAs-Quantentrogstrukturen / Christian Gradl ; Betreuer: Christian Schüller." Regensburg : Universitätsbibliothek Regensburg, 2018. http://d-nb.info/1151700096/34.

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Klingel, Susanne [Verfasser], and D. [Akademischer Betreuer] Gradl. "Konservierte und nicht-konservierte Funktionen der Lef/Tcf Transkriptionsfaktoren / Susanne Klingel. Betreuer: D. Gradl." Karlsruhe : KIT-Bibliothek, 2012. http://d-nb.info/1023081814/34.

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Gradl, Tobias [Verfasser], and Ulrich [Akademischer Betreuer] Rüde. "Data Structures and Algorithms for the Optimization of Hierarchical Hybrid Multigrid Methods / Tobias Gradl. Gutachter: Ulrich Rüde." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2015. http://d-nb.info/108154404X/34.

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Schunk, Jessica [Verfasser], and D. [Akademischer Betreuer] Gradl. "Funktionale Analyse nicht-konservierter Domänen der Lef/Tcf Transkriptionsfaktoren aus Xenopus laevis / Jessica Schunk. Betreuer: D. Gradl." Karlsruhe : KIT-Bibliothek, 2015. http://d-nb.info/1081213205/34.

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Nakhoul, Simon [Verfasser], Klaus [Gutachter] Peters, and Wolfgang [Gutachter] Gradl. "Inclusive charmonium production above 4 GeV at the BESIII experiment / Simon Nakhoul ; Gutachter: Klaus Peters, Wolfgang Gradl." Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg, 2021. http://d-nb.info/1228432562/34.

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Gradl, Stephan [Verfasser], Helmut [Akademischer Betreuer] Krcmar, and Martin [Akademischer Betreuer] Bichler. "Performance-Modellierung und Simulation eines SAP-ERP-Systems / Stephan Gradl. Gutachter: Helmut Krcmar ; Martin Bichler. Betreuer: Helmut Krcmar." München : Universitätsbibliothek der TU München, 2012. http://d-nb.info/1031513450/34.

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Books on the topic "GRDDL"

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Gradl, Hermann. Hermann Gradl: Der Malerromantiker und Landschaftsmaler. Marktheidenfeld am Main: H. Bröstler, 1989.

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Ignaz Gridl - Eisenkonstruktionen: Ingenieurbaukunst und Innovation im späten 19. Jahrhundert. Wien: Brandstätter, 2011.

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Astleitner, Hermann, Ines Deibl, Otto Lagodny, Patrick Warto, and Jörg Zumbach, eds. Rechtsdidaktik zwischen Theorie und Praxis. Nomos Verlagsgesellschaft mbH & Co. KG, 2019. http://dx.doi.org/10.5771/9783845294681.

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This edited volume presents several contributions from the second conference on the interrelationship between educational science and law, which took place in Austria in autumn 2016. The conference focused on the tension that arises when changes in the teaching and training of law are addressed. A perennial major concern within law education is the question of how it has to be applied in order to meet contemporary challenges, but so are other topics that address issues relating to the improvement of legal education. These considerations clearly show that the field of law education connects theory and practice and can improve the teaching of law significantly. With contributions by Rudolf Mosler, Michael Frey, Raimund Pittl, Lina Rosa Gradl, Ines Deibl, Jörg Zumbach, Viola Geiger, Christine Neuner, Natalia Hartmann, Christoph Görisch, Pamela Hölbling, Marcus Schladebach, Stephanie Moser, Tanja Thurner, Doris Lewalter, Kai von Lewinski, Raphael de Barros Fritz, Dana-Sophia Valentiner, Barbara Paesold, Karin Sonnleitner, Evelyne Schmid, Hermann Astleitner, Lutz Lammers, Patrick Warto, Jan-Gero Alexander Hannemann and Otto Lagodny.
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Book chapters on the topic "GRDDL"

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Yu, Liyang. "Other RDF-Related Technologies: Microformats, RDFa and GRDDL." In A Developer’s Guide to the Semantic Web, 97–119. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-662-43796-4_3.

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Yu, Liyang. "Other RDF-Related Technologies: Microformats, RDFa, and GRDDL." In A Developer’s Guide to the Semantic Web, 87–107. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-15970-1_3.

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Conference papers on the topic "GRDDL"

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Wilde, Erik. "Describing namespaces with GRDDL." In Special interest tracks and posters of the 14th international conference. New York, New York, USA: ACM Press, 2005. http://dx.doi.org/10.1145/1062745.1062839.

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Yong, Liu, Han Yongguo, and Jiang Yong. "Research on Sharing and Aggregating of Web Learning Materials Based on GRDDL and Topic-Oriented Crawler." In 2009 International Conference on Information Technology and Computer Science (ITCS 2009). IEEE, 2009. http://dx.doi.org/10.1109/itcs.2009.100.

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Lumb, L. I., and K. D. Aldridge. "Grid-Enabling the Global Geodynamics Project: Automatic RDF Extraction from the ESML Data Description and Representation via GRDDL." In 20th International Symposium on High-Performance Computing in an Advanced Collaborative Environment (HPCS'06). IEEE, 2006. http://dx.doi.org/10.1109/hpcs.2006.26.

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Richter, Wolfgang. "GridDL." In the 1st ACM workshop. New York, New York, USA: ACM Press, 2009. http://dx.doi.org/10.1145/1659029.1659039.

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Narayanan, Sai, Akhilesh Ramachandran, Sathyanarayanan N. Aakur, and Arunkumar Bagavathi. "GRaDL: A Framework for Animal Genome Sequence Classification with Graph Representations and Deep Learning." In 2020 19th IEEE International Conference on Machine Learning and Applications (ICMLA). IEEE, 2020. http://dx.doi.org/10.1109/icmla51294.2020.00203.

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