To see the other types of publications on this topic, follow the link: GRDDL.
Journal articles on the topic 'GRDDL'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 36 journal articles for your research on the topic 'GRDDL.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
Annisa, Viviane. "Review of Gastroretentive Drug Delivery System (GRDDS)." Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan 7, no. 1 (April 22, 2021): 1. http://dx.doi.org/10.33772/pharmauho.v7i1.11693.
Full textAbstract:
Penghantaran obat oral memiliki keterbatasan terkait dengan absorpsi pada saluran pencernaan yang tidak sempurna. Absorpsi yang tidak sempurna ini dapat mempengaruhi tercapainya dosis terapi. Hal ini dipengaruhi oleh lambung karena adanya faktor Gastro Residence Time (GRT). Untuk meningkatkan absorpsi obat pada lambung, maka memerlukan sistem penghantaran obat yang dapat memperlama GRT. Salah satu penghantaran obat yang dapat memperlama GRT adalah Gastroretentive Drug Delivery System (GRDDS). Pengembangan GRDDS memiliki banyak keuntungan, seperti meningkatkan bioavailabilitas obat, meningkatkan kelarutan obat yang kurang larut dalam pH tinggi, dapat mengontrol level terapi sehingga mengurangi terjadinya fluktuasi, serta dapat memperpanjang waktu paruh sehingga frekuensi pemberian obat dapat dikurangi. Faktor yang dapat mempengaruhi formulasi GRDDS adalah faktor farmasetika, fisiologis, dan kondisi pasien. Terdapat beberapa sistem dalam formulasi GRDDS, seperti sistem floating, bioadesif, densitas tinggi, superporos, expandable, raft forming, dan magnetik. Sistem floating dapat melalui 2 mekanisme pembuatan, yakni secara effervescent dan non-effervescent. Telah banyak bentuk sediaan dengan sistem GRDDS yang diproduksi dalam skala industri sehingga dapat ditemukan di pasaran.
2
Tripathi, Thapa, Maharjan, and Jeong. "Current State and Future Perspectives on Gastroretentive Drug Delivery Systems." Pharmaceutics 11, no. 4 (April 20, 2019): 193. http://dx.doi.org/10.3390/pharmaceutics11040193.
Full textAbstract:
In recent years, many attempts have been made to enhance the drug bioavailability and therapeutic effectiveness of oral dosage forms. In this context, various gastroretentive drug delivery systems (GRDDS) have been used to improve the therapeutic efficacy of drugs that have a narrow absorption window, are unstable at alkaline pH, are soluble in acidic conditions, and are active locally in the stomach. In this review, we discuss the physiological state of the stomach and various factors that affect GRDDS. Recently applied gastrointestinal technologies such as expandable, superporous hydrogel; bio/mucoadhesive, magnetic, ion-exchange resin; and low- and high-density-systems have also been examined along with their merits and demerits. The significance of in vitro and in vivo evaluation parameters of various GRDDS is summarized along with their applications. Moreover, future perspectives on this technology are discussed to minimize the gastric emptying rate in both the fasted and fed states. Overall, this review may inform and guide formulation scientists in designing the GRDDS.
3
v. Heyden. "Ueber Rhagonycha rhaetica Stierl. u. Scopolii Gredl." Berliner entomologische Zeitschrift 24, no. 1 (April 18, 2008): 227. http://dx.doi.org/10.1002/mmnd.18800240126.
Full text
4
Durga Srinivasarao M, Saravanakumar K., and Chandra Sekhar Kothapalli Bannoth. "Gastro-retentive drug delivery systems: a review with focus on ϐloating drug delivery systems." International Journal of Research in Pharmaceutical Sciences 12, no. 2 (May 1, 2021): 1330–37. http://dx.doi.org/10.26452/ijrps.v12i2.4684.
Full textAbstract:
Gastro-retentive drug delivery systems (GRDDS) attributes to gastric maintenance time combined with the medication discharge for expanded time has essentially improved patient consistency. Medications for which the chief fundamental site of ingestion is the stomach or the proximal piece of the small digestive tract or have the assimilation issue in the distal piece of the digestive system are reasonable for GRDDS. Orally sustaining or controlling the drug release combined with gastric retention property can avoid recurrent dosing in the case of drugs with short half-lives. GRDDS is also effective in locally treating gastric and duodenal ulcers, including oesophagitis and Helicobacter pylori infections. In this current survey, the physiology of the stomach alongside its motility design, typically called migrating motor complex (MMC), was discussed. Various approaches to GRDDS with a focus on floating drug delivery systems (FDDS) were reviewed. The vacillations in plasma drug focus are limited and portion subordinate unfriendly impacts can be forestalled by FDDS, particularly for the medications with a restricted restorative list. Slow arrival of the medication into the body by means of FDDS limits the counter movement prompting higher medication proficiency. Further, the Advantages, limitations, suitable drug candidates, factors affecting and Future challenges of FDDS were discussed.
5
Birajdar, Anuradha A., Madhuri T. Deshmukh, and Rajkumar V. Shete. "A Review on Gastro-Retentive Floating Microspheres." Journal of Drug Delivery and Therapeutics 11, no. 1-s (February 15, 2021): 131–38. http://dx.doi.org/10.22270/jddt.v11i1-s.4518.
Full textAbstract:
The floating microsphere's purpose is to improve gastric retention time. Floating drug delivery systems are lower in bulk thickness than gastric juice and remain floating on gastric juice for a long period of time without impacting the gastric-emptying rate and increasing bioavailability. Gastro-retentive microspheres are particularly suitable for the continuous or late release of oral formulations with blending versatility to achieve various release patterns, low dose risk as a reproducible and short gastric retention time. The aim of this review is to address literature on the floating device, techniques, selection of suitable or inappropriate drug candidates for GRDDS, low density polymers used to swim over gastric fluid, processes, and floating microsphere assessment and application.
Keywords: GRDDS, Floating system, Approaches, Polymer, Mechanism, Methods
6
Lin, Hong-Liang, Ling-Chun Chen, Wen-Ting Cheng, Wei-Jie Cheng, Hsiu-O. Ho, and Ming-Thau Sheu. "Preparation and Characterization of a Novel Swellable and Floating Gastroretentive Drug Delivery System (sfGRDDS) for Enhanced Oral Bioavailability of Nilotinib." Pharmaceutics 12, no. 2 (February 6, 2020): 137. http://dx.doi.org/10.3390/pharmaceutics12020137.
Full textAbstract:
Regarding compliance and minimization of side effects of nilotinib therapy, there is a medical need to have a gastroretentive drug delivery system (GRDDS) to enhance the oral bioavailability that is able to administer an optimal dose in a quaque die (QD) or daily manner. In this study, the influence on a swelling and floating (sf) GRDDS composed of a polymeric excipient (HPMC 90SH 100K, HEC 250HHX, or PEO 7000K) and Kollidon® SR was examined. Results demonstrated that PEO 7000K/Kollidon SR (P/K) at a 7/3 ratio was determined to be a basic GRDDS formulation with optimal swelling and floating abilities. MCC PH102 or HPCsssl,SFP was further added at a 50% content to this basic formulation to increase the tablet hardness and release all of the drug within 24 h. Also, the caplet form and capsule form containing the same formulation demonstrated higher hardness for the former and enhanced floating ability for the latter. A pharmacokinetic study on rabbits with pH values in stomach and intestine similar to human confirmed that the enhanced oral bioavailability ranged from 2.65–8.39-fold with respect to Tasigna, a commercially available form of nilotinib. In conclusion, the multiple of enhancement of the oral bioavailability of nilotinib with sfGRDDS could offer a pharmacokinetic profile with therapeutic effectiveness for the QD administration of a reasonable dose of nilotinib, thereby increasing compliance and minimizing side effects.
7
Kim, Hyeongmin, Chung-Lyol Lee, Seohyun Lee, Tae Jin Lee, Iqra Haleem, Younghong Lee, Na Jung Hwang, Kyusun Shim, Dohyun Kim, and Jaehwi Lee. "Mechanically Robust Gastroretentive Drug-Delivery Systems Capable of Controlling Dissolution Behaviors of Coground β-Lapachone." Pharmaceutics 11, no. 6 (June 10, 2019): 271. http://dx.doi.org/10.3390/pharmaceutics11060271.
Full textAbstract:
In this study, we aimed to design a highly swellable and mechanically robust matrix tablet (SMT) as a gastroretentive drug-delivery system (GRDDS) capable of improving the dissolution behavior of β-lapachone with low aqueous solubility. For the preparation of SMTs, the cogrinding technique and freeze–thaw method were used to disperse β-lapachone in SMTs in an amorphous state and to enhance the swelling and mechanical properties of SMTs, respectively. As a result, the crystallinity of coground β-lapachone incorporated in the SMTs was found to be considerably decreased; thereby, the dissolution rates of the drug in a simulated gastric fluid could be substantially increased. The SMTs of β-lapachone also demonstrated significantly enhanced swelling and mechanical properties compared to those of a marketed product. The reason for this might be because the physically crosslinked polymeric networks with a porous structure that were formed in SMTs through the freeze–thaw method. In addition, β-lapachone was gradually released from the SMTs in 6 h. Therefore, SMTs of β-lapachone developed in this study could be used as GRDDS with appropriate swelling and mechanical properties for improving the dissolution behavior of hydrophobic drugs such as β-lapachone.
8
Matharu, Amol S., Michael G. Motto, Mahendra R. Patel, Anthony P. Simonelli, and Rutesh H. Dave. "Evaluation of Hydroxypropyl Methylcellulose Matrix Systems as Swellable Gastro-Retentive Drug Delivery Systems (GRDDS)." Journal of Pharmaceutical Sciences 100, no. 1 (January 2011): 150–63. http://dx.doi.org/10.1002/jps.22252.
Full text
9
Kurrer, Karl-Eugen. "Ignaz Gridl. Eisenkonstruktionen. Ingenieurbaukunst und Innovation im späten 19. Jahrhundert. Fotografien von Nora Schoeller. Von Fogarassy, A." Stahlbau 82, no. 3 (March 2013): 228–29. http://dx.doi.org/10.1002/stab.201390037.
Full text
10
Raghu Kiran, Chintalapati V. S., and Chakka Gopinath. "Development and evaluation of interpenetrating polymer network based superporous hydrogel gastroretentive drug delivery systems (SPH IPN-GRDDS)." Materials Today: Proceedings 46 (2021): 3056–61. http://dx.doi.org/10.1016/j.matpr.2021.02.381.
Full text
11
Bandari, Suresh, Chandra Eaga, Ashok Thadishetty, and Madhusudan Yamsani. "Formulation and evaluation of multiple tablets as a biphasic gastroretentive floating drug delivery system for fenoverine." Acta Pharmaceutica 60, no. 1 (March 1, 2010): 89–97. http://dx.doi.org/10.2478/v10007-010-0001-3.
Full textAbstract:
Formulation and evaluation of multiple tablets as a biphasic gastroretentive floating drug delivery system for fenoverineA biphasic gastroretentive drug delivery system of fenoverine was developed to maintain constant plasma concentration. The delivery system consisted of a loading-dose tablet and a floating multiple matrix tablet prepared by the direct compression process. The drug release from biphasic GRDDS in 0.1 mol L-1HCl and SGF (enzyme free) was sustained over 12 h with buoyant properties. Stability studies showed no significant change in dissolution profiles (f2 value > 50). Based on the release kinetics, it can be concluded that the floating multiple matrix tablet containing HPMC was a particularly suitable gastroretentive drug delivery system with a zero-order release profile.
12
Singpanna, Kanokwan, Thapakorn Chareonying, Prasopchai Patrojanasophon, Theerasak Rojanarata, Monrudee Sukma, and Praneet Opanasopit. "Fabrication of a Floating Device of Domperidone Tablets Using 3D-Printing Technologies." Key Engineering Materials 859 (August 2020): 289–94. http://dx.doi.org/10.4028/www.scientific.net/kem.859.289.
Full textAbstract:
Gastro-retentive drug delivery systems (GRDDS) have been developed with the aim of prolonging drug release. In this study, floating device systems (FDS) were developed and incorporated with a domperidone tablet (Motilium-M®). The FDSs were made of polyvinyl alcohol (PVA) using a fused deposition modelling (FDM) 3D-printer and crosslinked by thermal crosslinking process. The morphology, water insolubilization, water uptake, thermal analysis, FT-IR, floating time and drug release were investigated. The results showed that thermal crosslinking caused the structural change of PVA. Increasing the crosslinking time increased the crystallinity of the polymer resulted in the decreased water solubility, water uptake, and swelling property. An optimal crosslinking condition for the FDS was heating at 120 °C for 6 h. Floating time of the FDS decreased after the crosslinking process. However, the sustained drug release of domperidone from the FDSs were observed after the thermal crosslinking process.
13
Yadav, Pawankumar H., Dipak P. Kardile, Madhuri T. Deshmukh, and Rajkumar V. Shete. "Hydrodynamically Balanced System: A Review." Journal of Drug Delivery and Therapeutics 11, no. 1-s (February 15, 2021): 147–53. http://dx.doi.org/10.22270/jddt.v11i1-s.4548.
Full textAbstract:
The most suitable drug delivery route is oral delivery due to its easily administration, patient adherence/ patient capacitance etc. Several approaches have been made for maximizing the G.R.T such as high-density system, floating system, swelling & expanding system and mucoadhesive & bio adhesive system etc. the main motive of reviewing the article is to focus on the mechanism of HBS system, classification with new system such as raft forming system and hollow microsphere, its application, marketed preparation and evaluation study. The procedure of gastric emptying is a complex and may leads to uncertainty for in vivo performance of the DDS. To prevent this type of complex formation and uncertainty, hard work has been done to expand the retention time of DDS for half of the day. The FDDS are beneficial in such process.
Keywords: HBS system, GRDDS, gastric residence time (G.R.T), raft forming systems, floating formulations, evaluation study.
14
Jeon, Gwanggil, and Abdellah Chehri. "Introduction to the special section on Security and Privacy Issues in Smart Grid by Applying Deep Learning Techniques (VSI-gridl)." Computers & Electrical Engineering 93 (July 2021): 107331. http://dx.doi.org/10.1016/j.compeleceng.2021.107331.
Full text
15
Shah, Harshil P., Shailesh T. Prajapati, and C. N. Patel. "GASTRORETENTIVE DRUG DELIVERY SYSTEMS: FROM CONCEPTION TO COMMERCIAL SUCCESS." Journal of Critical Reviews 4, no. 2 (March 16, 2017): 10. http://dx.doi.org/10.22159/jcr.2017v4i2.16717.
Full textAbstract:
Despite the extensive advancements in the field of drug delivery, the oral route remains the favorable route for administration of therapeutic actives. A success of oral controlled drug delivery systems is associated with reduced dosing frequency, decreased fluctuation in plasma drug concentration profile along with improved patient compliance. However, they are also associated with challenges like shorter gastric residence time, unpredictable gastric emptying and poor bioavailability for some molecules. This has initiated tremendous advancements in the field of gastro-retention to achieve controlled release of drugs along with improved bioavailability of drugs with narrow absorption window as well as localized action in the stomach and upper part of GIT. In present review, efforts have been envisaged to summarize our current understanding in the field of gastro-retention and their in vitro as well as in vivo characterization. Present review also highlights commercially utilized gastro-retentive technologies and some recently granted US patents in the field of GRDDS.
16
Kajal D. Chaudhari, Minakshee G. Nimbalwar, Nikita S. Singhal, Wrushali A. Panchale, Jagdish V. Manwar, and Ravindra L. Bakal. "Comprehensive review on characterizations and application of gastro-retentive floating drug delivery system." GSC Advanced Research and Reviews 7, no. 1 (April 30, 2021): 035–44. http://dx.doi.org/10.30574/gscarr.2021.7.1.0070.
Full textAbstract:
Current pharmaceutical situation focuses on the preparation of gastro-retentive floating drug delivery system (GRFDDS). This systems has gained noteworthy interest in the past decades. These are the low density systems that float over the gastric contents and remain buoyant in the stomach for a prolonged period of time without affecting the gastric emptying rate. GRFDDS is used to delay the residence time of delivery in stomach. The controlled gastric retention of solid dosage forms may be achieved by the mechanism of mucoadhesion, floatation, sedimentation, expansion, modified shape systems or by the administration of pharmacological agents that delaying gastric emptying. This results in targeting of release of drug at a specific site for the systemic or local effects. GRDDS is used to overcome challenges associated with conventional oral dosage forms and to release the drug at a specific absorption site to improve bioavailability of particular drug substance. Some floating drug delivery systems have shown the capability to accommodate these variations without affecting drug release. This review mainly focuses characterizations and application of gastro-retentive floating drug delivery systems.
17
G, Sai Mahesh, Suraj Narayana M, Glory Margaret P, Mohan Varma M, P. V. Swamy, and Ashok Thulluru. "Raft Forming Systems: A Novel Approach to Gastric Retention." International Journal of Pharmaceutical Sciences and Nanotechnology 14, no. 5 (September 1, 2021): 5594–602. http://dx.doi.org/10.37285/ijpsn.2021.14.5.3.
Full textAbstract:
Oral delivery of drug is the most preferable drug delivery due to the ease of administration, patient compliance and flexibility in the formulations. In recent era various technologies have been made in research and development of oral controlled release drug delivery system to overcome various physiological difficulties such as variation in gastric retention and emptying time. Conventional oral dosage forms pose low bioavailability problems due to their rapid gastric transition from stomach, especially in case of drugs which are less soluble at alkaline pH of intestine and locally acting drugs in stomach get rapidly emptied. So, frequency of dose administration in such cases is increased. Gastro retentive drug delivery system (GRDDS) is facing many challenges which can be overcome by upcoming newly emerging approach, raft forming systems (RFS). The present study provides valuable information and highlights advances in this raft forming system. Different types of smart polymers used for their formulation have also been summarized. The current review focuses on the mechanism, formulation development and evaluation aspects of the raft forming systems and also highlights parameters which may lead to response variations in altered physiological conditions are discussed as well.
18
Panda, Satyajit, K. Priyanka, R. Varaprasad, and Snigdha Pattnaik. "Gastroretentive Microspheres: An Innovative Approach for Prolonging Gastric Residence." International Journal of Drug Delivery Technology 9, no. 01 (January 9, 2019): 01–09. http://dx.doi.org/10.25258/ijddt.9.1.1.
Full textAbstract:
Gastro-retentive drug delivery systems (GRDDS) like gastro-retentive microspheres have gained immense popularity in the field of oral drug delivery. It is a widely employed approach to retain the dosage form in the stomach for an extended period of time and release the drug slowly that can address many challenges associated with conventional oral delivery, including poor bioavailability. Different innovative approaches like magnetic field assisted gastro-retention, swelling systems, mucoadhesion techniques, floating systems with or without effervescence are being applied to fabricate gastroretentive microspheres. Apart from in-vitro characterization, successful gastro-retentive microspheres development demands well designed in-vivo study to establish enhanced gastro-retention and prolonged drug release. Gama scintigraphy and MRI are popular techniques to evaluate in-vivo gastric residence time. However, checking of their overall in-vivo efficacy still remains a major challenge for this kind of dosage form, especially in small animals like mice or rat. Reported in-vivo studies with beagle dogs, rabbits, and human subjects are only a handful in spite of a large number of encouraging in-vitro results. In spite of the many advantages, high subject variations in gastrointestinal physiological condition, effect of food, and variable rate of gastric emptying time are the challenges that limit the availability of gastro-retentive microspheres in the market.
19
Karim, Abdul, Muhammad Ashraf Shaheen, Tahir Mehmood, Abdul Rauf Raza, Musadiq Aziz, and Badar Din. "Ranitidine Loaded Biopolymer Floats: Designing, Characterization, and Evaluation." Journal of Chemistry 2017 (2017): 1–12. http://dx.doi.org/10.1155/2017/6924601.
Full textAbstract:
The float formulation is a strategy to improve the bioavailability of drugs by gastroretentive drug delivery system (GRDDS). A drug delivery model based on swellable and reswellable low density biopolymers has been designed to evaluate its drug release profile using ranitidine (RNT) as a model drug and formulations have been prepared utilizing 32factorial designs. The drug release (DR) data has been subjected to various kinetic models to investigate the DR mechanism. A reduction in rate has been observed by expanding the amounts of PSG and LSG parts, while an expansion has been noted by increasing the concentration of tragacanth (TG) and citric acid (CA) with an increment in floating time. The stearic acid (SA) has been used to decrease the lag time because a decrease in density of system was observed. The kinetic analysis showed that the optimized formulation (S4F3) followed zero-order kinetics and power law was found to be best fitted due to its minimum lag time and maximum floating ability. The resemblance of observed and predicted values indicated the validity of derived equations for evaluating the effect of independent variables while kinetic study demonstrated that the applied models are feasible for evaluating and developing float for RNT.
20
Kohlstock, Ulf-Martin, Karl Peter Rücknagel, Michael Reuter, Angelika Schierhorn, Jan R. Andreesen, and Brigitte Söhling. "Cys359 of GrdD is the active-site thiol that catalyses the final step of acetyl phosphate formation by glycine reductase from Eubacterium acidaminophilum." European Journal of Biochemistry 268, no. 24 (December 15, 2001): 6417–25. http://dx.doi.org/10.1046/j.0014-2956.2001.02590.x.
Full text
21
Mohapatra, Prasanta Kumar, Ch Prathibha, Vivek Tomer, Mandeep Kumar Gupta, and Satyajit Sahoo. "DESIGN AND DEVELOPMENT OF LOSARTAN POTASSIUM FLOATING DRUG DELIVERY SYSTEMS." International Journal of Applied Pharmaceutics 10, no. 6 (November 22, 2018): 168. http://dx.doi.org/10.22159/ijap.2018v10i6.28782.
Full textAbstract:
Objective: The current study was projected to prepare a losartan potassium gastroretentive drug delivery system (GRDDS) of floating tablets was planned to enhance the gastric residence time, thus prolong the drug release.Methods: Effervescent floating matrix tablets of losartan potassium were prepared by direct compression technique using polymers like HPMC k4m, guar gum, and gum karaya, with lubricants magnesium stearate and talc. In the present study, sodium bicarbonate was incorporated as a gas generating agent. Total nine formulations were designed and evaluated for pre-compression parameters known as the angle of repose, bulk density, tapped density, Hausner’s ratio, compressibility index, and post-compression parameters are uniformity of weight, hardness, and drug content percentage, variability, in vitro buoyancy, dissolution studies, and Fourier transform infrared spectroscopy (FTIR).Results: An in vitro dissolution study was carried out by using buffer pH 1.2. From in vitro dissolution studies, it has been found that an increase in polymer concentration diminishes the drug release profile. The in vitro drug release percentage from F4-F9 formulations ranged from 60.28%-98.66% at the closing of 12 h and buoyancy found over 12 h.Conclusion: The in vitro drug release from F1-F3 and F7-F9 followed zero-order, F4 followed Higuchi order, F5 and F6 followed Hixon-Crowell release kinetics. The drug release mechanism was set up to be F1-F8 non-Fickian (anomalous behavior) and F9 having Fickian diffusion type.
22
Panigrahy, Rabi Narayan, Susanta Kumar Panda, and Prabhakar Reddy Veerareddy. "FORMULATION AND IN VITRO EVALUATION OF COMBINED FLOATING-BIOADHESIVE TABLETS OF IMATINIB MESYLATE." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 10 (November 1, 2017): 27. http://dx.doi.org/10.22159/ijpps.2017v9i11.18894.
Full textAbstract:
Objective: Gastro retentive drug delivery system (GRDDS) pertaining to its attributes like gastric retention time and the extended drug release profile has significantly improved patient compliance. The objective of the present study is to formulate and evaluate a stomach-specific floating-bioadhesive tablet of imatinib mesylate for prolonged residence in the stomach in the treatment of gastrointestinal stromal tumors (GIST).Methods: All the tablets were prepared with hydroxypropylmethylcellulose (HPMC), guar gum, sodium alginate, and carbopol using direct compression technique. Physical characterization, in vitro dissolution, the mucoadhesive force along with data analysis was done on each tablet. Results: The pre-compression characteristics of powder mixtures found to be satisfactory for all formulation batches. The results of physical evaluation for all batches were complying with pharmacopeia specification. The swelling index for all formulation batches was approximately 100% after 8 hours. The bioadhesive force (mean ± SD) reported in a range of 0.05 ± 0.09 to 0.18 ± 0.06 N/m2. It was observed that the release rate of tablets was decreased when the viscosity and concentration of the polymer were increased. Formulation batches IB1, IB2, IB4, IB5, IB6, IB9, IB10, IB11, and IB13 follows Higuchi Matrix model kinetics; whereas IB3, IB7, IB8, and IB12 follows Korsmeyer- Peppas model kinetics.Conclusion: Formulation batch IB9 reported a considerable swelling index, floating behavior, more bioadhesive strength with uniform drug release pattern. Therefore formulation batch IB9 was selected as optimized batch and were kept for further evaluation studies.
23
Pund, Aniket Uttam, Raosaheb Sopanrao Shendge, and Ajinkya Kailas Pote. "Current Approaches on Gastroretentive Drug Delivery systems." Journal of Drug Delivery and Therapeutics 10, no. 1 (January 15, 2020): 139–46. http://dx.doi.org/10.22270/jddt.v10i1.3803.
Full textAbstract:
Over recent years, there have been many efforts to develop the absorption rate of medications and the therapeutic efficacy of oral dosage types. GRDDS for strengthen the pharmacological effects of drugs with a small uptake site, are unbalanced at pH greater than 7, are dissolved under acidic region, and are effective local region in the stomach. The gastro retentive systems that have the different evaluation parameter that according to the dosage forms. There are many criteria for the choosing of the drug used in the gastro-retardant systems as the drug should be sparingly stable, it should be compatible with the gastric region, and narrow absorption. In this review, we have summarized the information related to the various approaches for enhancing and prolonging of the dosage forms in the stomach for their extended-release of action. Also talking about the many natural and synthetic polymers is used in the formulation with their different grade and their ratio that affects on the release action. The many scientist and inventors have increased their interest in developing the novel dosage forms and they staying in the stomach for showing the prolonged period action. We have also discussed the novel technology are involved in the gastric retention many companies has been developed the polymer grades for using it in the formulation for showing the retention action.
Keywords: Introduction, Approaches, Novel technologies, Polymer used in floating systems.
24
Hasan, Md Asif, Sabiha Sultana, Sabiha Sultana, Md Masud Kaisar Bhuiyan, Md Selim Reza, and Mohammad Salim Hossain. "Formulation and In vitro Characterization of Hydrochlorothiazide Gastroretentive Floating Drug Delivery System." Dhaka University Journal of Pharmaceutical Sciences 14, no. 2 (June 28, 2016): 163–70. http://dx.doi.org/10.3329/dujps.v14i2.28506.
Full textAbstract:
The purpose of the study was to develop and optimize floating bioadhesive gastroretentive drug delivery system (GRDDS) exhibiting a unique combination of floatation and bioadhesion to prolong residence in the stomach, using hydrochlorothiazide (HCTZ) as a model drug. Formulated matrix tablets were prepared by direct compression method with two different rate controlling polymer HPMC K4M and Carbopol 971. The formulated tablets were evaluated for physical characterization, floating lag time, swelling index and drug content uniformity. The drug release study was carried out in 0.1N HCl as the medium (pH 1.2) for 8 hours using USP type II dissolution apparatus and investigated the effects of polymers on the drug release profile. In vitro buoyancy study results found to be 1033 sec and >8 h, floating lag time and total floating time respectively. Simulated drug release pattern in different kinetic models of Korsmeyer-Peppas release suggests that the mechanism controlling of the drug release from all formulations was the anomalous non-Fickian or anomalous release. Polymer with lower viscosity (HMPC K4M) was found to be beneficial than higher viscosity polymer (Carbopol 971) in improving the release properties of gastric floating drug delivery system. Incorporation of Carbopol in formulation also helped in maintaining buoyancy of system with desirable drug release. Further study is necessary in case of in vitro- in vivo relationship, but this study will ready to lend a hand to future scientists working in this field to successfully exploit the potential of this drug delivery system for the advantage of mankind.Dhaka Univ. J. Pharm. Sci. 14(2): 163-170, 2015 (December)
25
Nigusse, Birhanu, Tsige Gebre-Mariam, and Anteneh Belete. "Design, development and optimization of sustained release floating, bioadhesive and swellable matrix tablet of ranitidine hydrochloride." PLOS ONE 16, no. 6 (June 25, 2021): e0253391. http://dx.doi.org/10.1371/journal.pone.0253391.
Full textAbstract:
Ranitidine HCl, a selective, competitive histamine H2-receptor antagonist with a short biological half-life, low bioavailability and narrow absorption window, is an ideal candidate for gastro-retentive drug delivery system (GRDDS). Controlled release with an optimum retentive formulation in the upper stomach would be an ideal formulation for this drug. The aim of the present study was therefore to develop, formulate and optimize floating, bioadhesive, and swellable matrix tablets of ranitidine HCl. The matrix tablets were prepared using a combination of hydroxypropyl methylcellulose (HPMC) and sodium carboxymethyl cellulose (NaCMC) as release retarding polymers, sodium bicarbonate (NaHCO3) as gas generating agent and microcrystalline cellulose (MCC) as direct compression diluent. Central composite design (CCD) was used to optimize the formulation and a total of thirteen formulations were prepared. Concentration of HPMC/NaCMC (3:1) (X1) and NaHCO3 (X2) were selected as independent variables; and floating lag time (Y1), bioadhesive strength (Y2), swelling index at 12 h (Y3), cumulative drug release at 1 h (Y4), time to 50% drug release (t50%) (Y5) and cumulative drug release at 12 h (Y6) were taken as the response variables. The optimized batch showed floating lag time of 5.09 sec, bioadhesive strength of 29.69 g, swelling index of 315.04% at 12 h, t50% of 3.86 h and drug release of 24.21% and 93.65% at 1h and 12 h, respectively, with anomalous release mechanism. The results indicate that sustained release matrix tablet of ranitidine HCl with combined floating, bioadhesive and swelling gastro-retentive properties can be considered as a strategy to overcome the low bioavailability and in vivo variation associated with the conventional ranitidine HCl tablet.
26
SIKES, DEREK S., RONALD B. MADGE, and ALFRED F. NEWTON. "A catalog of the Nicrophorinae (Coleoptera: Silphidae) of the world." Zootaxa 65, no. 1 (August 29, 2002): 1. http://dx.doi.org/10.11646/zootaxa.65.1.1.
Full textAbstract:
All available species-group names of the subfamily Nicrophorinae (Coleoptera: Silphidae) are cataloged herein. There are currently 68 valid species, three of which are fossils; and 168 invalid species-group names, 2 of which are nomina dubia and 17 of which are junior homonyms and thus objectively invalid; for a total of 236 available species-group names. The type specimens of 38 valid names and 63 invalid names were found and studied. The original descriptions of 65 valid species-group names and 130 invalid species-group names were found and studied. An annotated bibliography of 1151 references that cite nicrophorine names covering the years 1752 – early 2002 is presented. The following 18 nomenclatural acts are made: Lectotype designations (16): Type depositories precede species names. HNHM: Budapest: Nicrophorus antennatus (Reitter) / BMNH: London: Nicrophorus interruptus Stephens; Nicrophorus mexicanus Matthews; Nicrophorus montivagus Lewis; Nicrophorus tenuipes Lewis / MNHN: Paris: Nicrophorus didymus Brullé; Nicrophorus insularis Grouvelle; Nicrophorus interruptus var. algiricus Pasquet; Nicrophorus podagricus Portevin; Nicrophorus quadraticollis Portevin; Nicrophorus scrutator Blanchard / ZMAS: St. Petersburg: Nicrophorus mongolicus ShchegolevaBarovskaya; Nicrophorus przewalskii Semenov-Tian-Shanskij; Nicrophorus reichardti Kieseritzky / ZMHB: Berlin: Nicrophorus japonicus Harold / MCZC: Cambridge: Nicrophorus defodiens Mannerheim; New nomina protecta/oblita (2): Silpha (Nicrophorus) orientalis (Herbst,1784) NEW NOMEN OBLITUM (article 23.9.2 ICZN ed. 4); Nicrophorus americanus Olivier, 1790 NEW NOMEN PROTECTUM (see N. orientalis); The following 93 taxonomic changes are made: New status as valid species (2): Nicrophorus sepulchralis Heer NEW STATUS as valid species; Nicrophorus morio Gebler NEW STATUS as valid species; New combination (1): Silpha (Nicrophorus) orientalis Herbst NEW COMBINATION as Nicrophorus orientalis (Herbst); New species-group revised synonyms (12): These are junior synonyms or names of subspecific rank that are being moved to new senior synonyms (as absolute synonyms, i.e. rankless): N. tibetanus Hlisnikovsky REVISED SYNONYM of N. argutor Jakovlev; N. lateralis Portevin REVISED SYNONYM of N. defodiens Mannerheim; N. plagiatus Motschulsky REVISED SYNONYM of N. defodiens Mannerheim; N. humeralis Pic REVISED SYNONYM of N. insularis Grouvelle; N. gallicus Jacquelin du Val REVISED SYNONYM of N. interruptus Stephens; N. suturalis Motschulsky REVISED SYNONYM of N. interruptus Stephens; N. submaculatus Reitter REVISED SYNONYM of N. investigator Zetterstedt; N. funebris Jakovlev REVISED SYNONYM of N. morio Gebler; N. requiescator Gistel REVISED SYNONYM of N. tomentosus Weber; N. interruptiolus Strand REVISED SYNONYM of N. vestigator Herschel; N. interruptus Brullé REVISED SYNONYM of N. brullei Jakobson, (syn. of N. vestigator Herschel); P. weberi Bodemeyer REVISED SYNONYM of Ptomascopus plagiatus (Ménétriés); New species-group synonyms (25): These are species-group names of specific rank that have not been synonymized previously. N. pseudobrutor Reitter NEW SYNONYM of N. argutor Jakovlev; N. cadaverinus Gistel NEW SYNONYM of N. germanicus (L.); N. ornatus Hlisnikovsky NEW SYNONYM of N. germanicus (L.); N. proserpinae Gistel NEW SYNONYM of N. germanicus (L.); N. basalis Gistel NEW SYNONYM of N. interruptus Stephens; N. fossor Erichson NEW SYNONYM of N. interruptus Stephens; N. grahami Swan & Papp NEW SYNONYM of N.investigator Zetterstedt; N. maritimus Gistel NEW SYNONYM of N. investigator Zetterstedt; N. praedator (Reitter) NEW SYNONYM of N. investigator Zetterstedt; N. karafutonis Kôno NEW SYNONYM of N. maculifrons Kraatz; N. lunulatus Gistel NEW SYNONYM of N. marginatus Fabricius; N. lunatus Gistel NEW SYNONYM of N. marginatus Fabricius; N. mixtus Hlisnikovsky NEW SYNONYM of N. montivagus Lewis; N. rugulipennis Jakovlev NEW SYNONYM of N. morio Gebler; N. benguetensis Arnett NEW SYNONYM of N. nepalensis Hope; N. burmanicus Hlisnikovsky NEW SYNONYM of N. oberthuri Portevin; N. unifasciatus Hlisnikovsky NEW SYNONYM of N. oberthuri Portevin; N. pulsator Gistel NEW SYNONYM of N. sayi Laporte; N. temporalis Shchegoleva-Barovskaya NEW SYNONYM of N. semenowi (Reitter); N. fasciatus Hlisnikovsky NEW SYNONYM of N. tenuipes Lewis; N. marginatus Gistel NEW SYNONYM of N. tomentosus Weber; N. bifasciatus Hausmann NEW SYNONYM of N. vespillo (L.); N. hadenius Gistel NEW SYNONYM of N. vespillo (L.); N. oregonensis Swann & Papp NEW SYNONYM of N. vespilloides Herbst; N. olfactor Gistel NEW SYNONYM of N. vestigator Herschel; New status as absolute synonyms (53): These are species-group names of subspecific rank that we consider to be invalid synonyms without rank. N. centralis Portevin NEW STATUS as absolute syn. of N. antennatus (Reitter); N. rotundicollis Portevin NEW STATUS as absolute syn. of N. concolor Kraatz; N. armeniacus Portevin NEW STATUS as absolute syn. of N. germanicus (L.); N. bimaculatus Haworth NEW STATUS as absolute syn. of N. germanicus (L.); N. bipunctatus Kraatz NEW STATUS as absolute syn. of N. germanicus (L.); N. fascifer (Reitter) NEW STATUS as absolute syn. of N. germanicus (L.); N. speciosus (J.D. Schulze) NEW STATUS as absolute syn. of N. germanicus (L.); N. quadriguttata Angell NEW STATUS as absolute syn. of N. guttula Motschulsky; N. vandykei Angell NEW STATUS as absolute syn. of N. guttula Motschulsky; N. atricornis Meier NEW STATUS as absolute syn. of N. humator (Gleditsch); N. maculosus Meier NEW STATUS as absolute syn. of N. humator (Gleditsch); N. minnesotianus Hatch NEW STATUS as absolute syn. of N. hybridus Hatch & Angell; N. brunnipes Gradl NEW STATUS as absolute syn. of N. interruptus Stephens; N. centrimaculatus Reitter NEW STATUS as absolute syn. of N. interruptus Stephens; N. corsicus Laporte NEW STATUS as absolute syn. of N. interruptus Stephens; N. funereus Géné NEW STATUS as absolute syn. of N. interruptus Stephens; N. infuscaticornis Portevin, NEW STATUS as absolute syn. of N. interruptus Stephens; N. laportei Meier NEW STATUS as absolute syn. of N. interruptus Stephens; N. nigricans Pasquet NEW STATUS as absolute syn. of N. interruptus Stephens; N. pasqueti Pic NEW STATUS as absolute syn. of N. interruptus Stephens; N. trimaculatus Gradl NEW STATUS as absolute syn. of N. interruptus Stephens; N. trinotatus Reitter NEW STATUS as absolute syn. of N. interruptus Stephens; N. vodozi Meier NEW STATUS as absolute syn. of N. interruptus Stephens; N. algiricus Pasquet NEW STATUS as absolute syn. of N. interruptus Stephens; N. funerator Fauvel NEW STATUS as absolute syn. of N. investigator Zetterstedt; N. funeror (Reitter) NEW STATUS as absolute syn. of N. investigator Zetterstedt; N. insularis Lafer NEW STATUS as absolute syn. of N. investigator Zetterstedt; N. intermedius Reitter NEW STATUS as absolute syn. of N. investigator Zetterstedt; N. latifasciatus Lewis NEW STATUS as absolute syn. of N. investigator Zetterstedt; N. maritimus Mannerheim NEW STATUS as absolute syn. of N. investigator Zetterstedt; N. variolosus Portevin NEW STATUS as absolute syn. of N. investigator Zetterstedt; N. parvulus Hlisnikovsky NEW STATUS as absolute synonym of N. maculifrons Kraatz; N. nigrifrons Portevin NEW STATUS as absolute syn. of N. podagricus Portevin; N. immaculatus Portevin NEW STATUS as absolute syn. of N. quadripunctatus Kraatz; N. bohemicus Roubal NEW STATUS as absolute syn. of N. vespillo (L.); N. bolsmanni Westhoff NEW STATUS as absolute syn. of N. vespillo (L.); N. fauveli Fauconnet NEW STATUS as absolute syn. of N. vespillo (L.); N.minor Westhoff NEW STATUS as absolute syn. of N. vespillo (L.); N. varendorffi Westhoff NEW STATUS as absolute syn. of N. vespillo (L.); N. altumi Westhoff NEW STATUS as absolute syn. of N. vespilloides Herbst; N. aurora Motschulsky NEW STATUS as absolute syn. of N. vespilloides Herbst; N. subfasciatus Portevin NEW STATUS as absolute syn. of N. vespilloides Herbst; N. subinterruptus Pic NEW STATUS as absolute syn. of N. vespilloides Herbst; N. sylvivagus Reitter NEW STATUS as absolute syn. of N. vespilloides Herbst; N. brullei Jacobson NEW STATUS as absolute syn. of N. vestigator Herschel; N. bipunctatus Portevin NEW STATUS as absolute syn. of N. vestigator Herschel; N. carreti Pic NEW STATUS as absolute syn. of N. vestigator Herschel; N. degener Carret NEW STATUS as absolute syn. of N. vestigator Herschel; N. obscuripennis Portevin NEW STATUS as absolute syn. of N. vestigator Herschel; N. rautenbergi Reitter NEW STATUS as absolute syn. of N. vestigator Herschel; N. viturati Pic NEW STATUS as absolute syn. of N. vestigator Herschel; P. lewisi Portevin NEW STATUS as absolute syn. of P. morio Kraatz; P. villosus Portevin NEW STATUS as absolute syn. of P. morio Kraatz.
27
J BHANDWALKAR, MANDAR, PRASAD S DUBAL, AKASH K.TUPE, and SUPRIYA N MANDRUPKAR. "REVIEW ON GASTRORETENTIVE DRUG DELIVERY SYSTEM." Asian Journal of Pharmaceutical and Clinical Research, December 7, 2020, 38–45. http://dx.doi.org/10.22159/ajpcr.2020.v13i12.37264.
Full textAbstract:
In recent years, gastroretentive drug delivery system (GRDDS) has gained researcher’s interest in the field of oral drug delivery. Various GRDDS approaches can be utilized to retain the dosage forms in the stomach and to release the drug slowly for an extended period of time. GRDDS can be used to prolong the residence time of delivery system in the stomach. This results in targeting of drug release at a specific site for the systemic or local effects. GRDDS can be used to overcome challenges associated with conventional oral dosage forms and to release the drug at a specific absorption site to improve bioavailability of particular drug substance. The challenges include fast gastric emptying of the dosage form which results in the poor bioavailability of the drug. Prolongation of the retention of drugs in stomach those having low solubility at high intestinal pH improves the solubility of drugs. GRDDS has proved to be effective in systemic actions as well as in local actions to treat gastric or duodenal ulcers. Local activity in the upper part of the small intestine can be obtained by improving the residence time of delivery system in the stomach. The system is useful for drugs which are unstable in the intestine or having a low solubility/permeability in the small intestine. Various GRDDS approaches include high density (sinking) systems, low-density (floating systems), mucoadhesive, expandable, unfoldable, superporous hydrogel systems, and magnetic systems.
28
Jassal, Meenakshi, Ujjwal Nautiyal, Jyotsana Kundlas, and Devendra Singh. "A review: Gastroretentive drug delivery system (grdds)." Indian Journal of Pharmaceutical and Biological Research 3, no. 01 (March 31, 2015). http://dx.doi.org/10.30750/ijpbr.3.1.13.
Full textAbstract:
One novel approach in this area is GRDDSs (Gastro Retentive Drug Delivery System). GRDDSs can improve the controlled delivery of drugs that have an absorption window by continuously releasing the drug for a prolonged period of time before it reaches its absorption site.The purpose of writing this review was to investigate, compile and present the recent as well as past literatures in more concise way with special focus on approaches which are currently utilized in the prolongation of gastric residence time. These includes floating system, swelling and expanding system, bio/mucoadhesive system, high density system and other delayed gastric emptying devices. The present review addresses briefly about the classification, formulation consideration for GRDDS, factors controlling gastric retention, merits, demerits and applications of gastroretentive drug delivery systems.
29
Bhavsar, Dhaval N. "ADVANCES IN GRDDS: RAFT FORMING SYSTEM A REVIEW." Journal of Drug Delivery and Therapeutics 2, no. 5 (September 15, 2012). http://dx.doi.org/10.22270/jddt.v2i5.228.
Full text
30
Mathur, Pooja, Vikas Jhawat, and Rohit Dutt. "New Insights into Gastroretentive Dosage Forms In Delivery of Drugs." Current Nanomedicine 11 (June 3, 2021). http://dx.doi.org/10.2174/2468187311666210603121313.
Full textAbstract:
: The oral drug delivery route is preferable to deliver the therapeutic agents because of the low cost, flexibility in dosage form, and easy administration of drugs responsible for a high range of patient compliances. GRDDS is also an oral route of drug delivery system to prolong gastric residence time, thereby achieving site-specific drug release in the upper GIT for local or systemic effect. Various strategies for developing systematic GRDDS include approaches with less density than stomach contents, systems with high density, swellable and expanding strategies, formulation of super porous hydrogels, gas generating systems, hydrodynamically balanced, raft forming approaches, floating drug delivery, and dual working systems. The massive challenge in developing systemic GRDDSs is inter and intra-individual differences in gastric physiology. Despite so many formulation strategies, these systems might be associated with few benefits as well as drawbacks. Drawbacks with few approaches can be overthrown by formulating novel dual working systems such as Mucoadhesive floating drug delivery system (MFDDS). These systems can form an intimate contact of the formulation with the stomach's mucosal membrane and increase the dosage formulation's absorption at the target site. The present compilation aims to outline the stomach's physiological state, ideal characteristics of drugs for GRDDS, key factors impacting GRDF efficacy, and gastroretentive formulation strategies that could become the critical processes in the area of pharmaceutical research for target drug delivery. It also explores various marketed products of GRDDS and future perspectives.
31
C., KANUPRIYA, NIMRATA SETH, and N. S. GILL. "GASTRO RETENTIVE DRUG DELIVERY SYSTEM: A SIGNIFICANT TOOL TO INCREASE THE GASTRIC RESIDENCE TIME OF DRUGS." International Journal of Current Pharmaceutical Research, January 15, 2021, 7–11. http://dx.doi.org/10.22159/ijcpr.2021v13i1.40818.
Full textAbstract:
Writing the review on gastro retentive drug delivery systems (GRDDS) was to start up the current literature with a special consequence on several gastro retentive approaches that have become main mode in the field of site-specific orally conduct sustained/controlled release drug delivery. Multi-furious ways have been made in research and development to rate-controlled oral drug delivery systems to solve physiological difficulties, like short gastric residence times (GRT) and unpredictable gastric emptying times (GET). GRDDS is a tool to prolong the GRT, thereby targeting site-specific drug release in the upper gastrointestinal tract (GIT) for local or systemic effect. Oral dosage forms as low bioavailability issues because of their swift gastric transition from the stomach, particularly in the case of drugs that are less soluble at an alkaline pH of the intestine. The drugs that produce their local action in the stomach get quickly emptied and don’t get enough residence time in the stomach. Many efforts have been made to extend the retention time of a drug delivery system to reduce the frequency of dose administration. GRDDS not only prolong dosing intervals but also increase patient compliance beyond the level of existing controlled release dosage forms. This article gives an overview of the advantages, disadvantages, and characterization of gastro retentive drug delivery systems. This also includes commercially available gastro retentive products and patents.
32
Siraj, Shaikh Nawaj, Saleem Mau Patel, G. J. Khan, K. I. Molvi, PATEL M. Siddik, and Shaoor Ahmad. "INSIGHT IN TO APPLICATIONS OF THERMAL SINTERING TECHNIQUE IN NDDS SPECIALLY GRDDS." Journal of Drug Delivery and Therapeutics 7, no. 5 (September 15, 2017). http://dx.doi.org/10.22270/jddt.v7i5.1510.
Full text
33
KRISHNA, ABHISHEK KUMAR, and RAJAT SRIVASTAVA. "IN VITRO IN VIVO STUDIES ON FLOATING MICROSPHERES FOR GASTRORETENTIVE DRUG DELIVERY SYSTEM: A REVIEW." Asian Journal of Pharmaceutical and Clinical Research, January 5, 2021, 13–26. http://dx.doi.org/10.22159/ajpcr.2021.v14i1.39183.
Full textAbstract:
The purpose of writing this review on gastroretentive drug delivery systems (GRDDS) was to compile the recent literature with a special focus on various gastroretentive approaches that have recently become leading methodologies in the field of site-specific orally administered controlled release drug delivery. One of the complex processes in the human body is gastric emptying, as it is highly variable, which makes the in vivo performance of the drug delivery systems uncertain. GRDDS has gained immense popularity in the field of oral drug delivery recently. It is a widely employed approach to retain the dosage form in the stomach for an extended period of time and release the drug slowly that can address many challenges associated with the conventional oral delivery system. Conventional drug delivery systems may not overcome the issues imposed by the gastrointestinal tract (GIT) such as incomplete release of drugs, decrease in dose effectiveness, and frequent dose requirement. To overcome this variability, a controlled drug delivery system with a prolonged gastric residence time of >12 h in the stomach can be of great practical importance for drugs with an absorption window in the upper small intestine. GRDFs enable prolonged and continuous release of the drug to the upper part of the GIT and thus significantly extend the duration of drug release and improve the bioavailability of drugs that have a narrow therapeutic window; by this way, they prolong dosing interval and increase compliance.
34
"A review on compatibility study of sucralfate and metoprolol succinate for the formulation of bilayer floating tabletas a GRDDS." International Journal of Pharmaceutical Research 11, no. 4 (October 1, 2019). http://dx.doi.org/10.31838/ijpr/2019.11.04.024.
Full text
35
Putri, Aristha Novyra, and Dyera Forestryana. "Formulasi dan Karakterisasi Fisik Tablet Floating Mukoadhesif Ranitidin HCl." Jurnal Pharmascience 4, no. 2 (November 5, 2017). http://dx.doi.org/10.20527/jps.v4i2.5771.
Full textAbstract:
Gastrotentive Drug Delivery System merupakan sistem penghantar yang bermanfaat untuk memperpanjang waktu tinggal sediaan di dalam lambung yang bertujuan untuk pemberian obat lokal pada saluran cerna bagian atas ataupun untuk efek sistemik. Ranitidin hydrochloride (RHCl) adalah golongan histamine H2 receptor antagonist memiliki waktu paro ranitidine HCl yaitu 2 – 3 jam, bioavailabilitas absolut ranitidine HCl 50%, ranitidin HCl sangat baik diabsorbsi di lambung, dan dimetabolisme di kolon, sehingga bioavailabilitas di kolon sangat rendah, sehingga cocok dikembangkan dalam bentuk Gastroretentive Drug Delivery System (GRDDS). Penilitian ini bertujuan untuk memformulasi sediaan tablet floating mukoadhesif Rantidin HCl berdasarkan rancangan formula factorial design 23, sehingga menghasilkan 8 formula. Selanjutnya dilakukan uji karakteristik fisik granul dan tablet tablet floating mukoadhesif Rantidin HCl. Penelitian ini dapat disimpulkan bahwa kecepatan alir granul ada rentang 4,599±0,115 - 7,615±0,081 gr/detik; sudut diam pada rentang 26,47±0,164 - 30,31°±1,769; fisik tablet keseluruhan formula berbentuk bulat; warna putih kekuningan; memiliki diameter 12,9 mm; ketebalan tablet 2,8 ± 0,05 - 3,53 ± 0,05 mm; rentang rata – rata bobot tablet 8 formula adalah 478,2±0,81 - 578,3±0,64 mg; friability pada rentang 0,28±0,002 - 0,47±0,002 %; dan uji swelling index terjadi pengembangan tablet dari waktu ke waktu selama 6
Kata kunci: Ranitidin HCl, floating-muccoadhesive, swelling index, Gastroretentive, Factorial Design
36
Rathor, Sandeep, Sheikh Aamir, D. C. Bhatt, Krishan Kumar, and Vikash Kumar. "A comprehensive review on microbubble concept, development and its application in therapeutics drug delivery and clinical management of disease." Current Pharmaceutical Biotechnology 21 (November 9, 2020). http://dx.doi.org/10.2174/1389201021999201109221102.
Full textAbstract:
Background:: The general purpose of this review was to briefly describe the gastro-retentive drug delivery system (GRDDS) and primary focuses on mechanisms of flotation for gastric retention. The principle mechanism of floating drug delivery systems (FDDS) is mainly based on hydro-dynamically controlled low-density system which gets swollen when come in contact with gastric environment and remain buoyant for extended period of time with improved bioavailability and therapeutic efficacy. The main perspective of this review was to focus on microbubble drug delivery due to its wide range of application. Microbubble is a new, economically viable and non-invasive technique which is alternative to conventional techniques. The size of microbubble ranges from 1-100 micrometers which contain oxygen or air and remain suspended for prolonged drug release. Due to its great potential microbubble is used in therapeutic delivery of drug molecule or genetic material at their specific targeted site in various diseases. The recent research also suggests that ultrasound mediated microbubble is more frequently used in biomedical field for imaging of site-specific molecule targeting for detection of disease and site-specific drug delivery. Conclusion:: Gastro-retentive floating drug delivery system was considered as most favorable approach for site-specific drug delivery. But nowadays, microbubble is gaining more popularity for its potential application in biomedical field. In recent years, there is much progress in microbubble for site specific delivery of drug or genetic material. Recent research also suggests that the ultrasound mediated microbubble have shown positive impact in the diagnosis and clinical management of various diseases such as Liver Cirrhosis, brain tumor, ocular and urinary tract infection.