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Berner, D. K., C. A. Cavin, M. B. McMahon, and I. Loumbourdis. "First Report of Anthracnose of Salsola tragus Caused by Colletotrichum gloeosporioides in Greece." Plant Disease 90, no. 7 (July 2006): 971. http://dx.doi.org/10.1094/pd-90-0971b.
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In early October of 2005, dying Salsola tragus L. (Russian thistle, tumbleweed), family Chenopodiaceae, plants were found along the Aegean Sea at Kryopigi Beach, Greece (40°02′29″N, 23°29′02″E, elevation 0 m). All of the 30 to 40 plants in the area were diseased and approximately 80% were dead or dying. All plants were relatively large (approximately 1 m tall × 0.5 m diameter), and living portions of diseased plants were flowering. Dying plants had irregular, necrotic lesions extending the length of the stems. Leaves of these plants were also necrotic. Lesions on stems and leaves were dark brown and usually coalesced. Diseased stem pieces were taken to the European Biological Control Laboratory, USDA, ARS at the American Farm School in Thessaloniki, Greece. There, diseased stem pieces were surface disinfested for 15 min with 0.5% NaOCl and placed on moist filter paper in petri dishes. Numerous, waxy subepidermal acervuli with black setae were observed in all lesions after 2 to 3 days. Conidiophores were simple, short, and erect. Conidia were one-celled, hyaline, ovoid to oblong, falcate to straight, 12.9 to 18.0 × 2.8 to 5.5 μm (mode 16.1 × 4.5 μm). These characters conformed to the description of Colletotrichum gloeosporioides (Penz.) Penz. & Sacc. in Penz. (2). Conidia were placed on modified potato carrot agar and axenic cultures from these isolations were sent to the quarantine facility of the Foreign Disease-Weed Science Research Unit, USDA, ARS, Fort Detrick, MD for testing. On the basis of DNA sequences, two variants within S. tragus have been described in California and named “Type A” and “Type B” (1). Conidia were harvested from 14-day-old cultures grown on 20% V8 juice agar, and healthy stems and leaves of 18 30-day-old plants of S. tragus Type A and 10 Type B plants were spray inoculated with an aqueous conidial suspension (1.0 × 106 conidia/ml plus 0.1% non-ionic surfactant). Three control plants of each type were sprayed with water and surfactant only. Plants were placed in an environmental chamber (18 h of dew in darkness at 25°C). After 1 day, all plants were transferred to a greenhouse (20 to 25°C, 30 to 50% relative humidity, and natural light augmented with 12-h light periods with 500-W sodium vapor lights). Lesions developed on stems of inoculated Type A plants after 5 days. After 14 days, all inoculated Type A plants were dead. Lesions on Type B plants were small and localized; all plants were diseased but no plants died. No symptoms occurred on control plants. C. gloeosporioides was reisolated 14 to 21 days after inoculation from stem pieces of all inoculated plants of both types of S. tragus. This isolate of C. gloeosporioides is a destructive pathogen on S. tragus Type A and is a potential candidate for biological control of this weed in the United States. To our knowledge, this is the first report of anthracnose caused by C. gloeosporioides on S. tragus in Greece. A voucher specimen has been deposited with the U.S. National Fungus Collections, Beltsville, MD (BPI 871126). Nucleotide sequences for the internal transcribed spacers (ITS 1 and 2) were deposited in GenBank (Accession No. DQ344621) and exactly matched sequences of the teleomorph, Glomerella cingulata. References: (1) F. Ryan and D. Ayres. Can. J. Bot. 78:59, 2000. (2) B. C. Sutton. Page 15 in: Colletotrichum Biology, Pathology and Control. J. A. Bailey and M. J. Jeger, eds. CAB International Mycological Institute, Wallingford, UK, 1992.
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MUHAMMAD, DILSHAD, KHALID AMIN, AMIN ANJUM, and Masood Javed. "CHRONIC HEPATITIS C VIRUS INFECTION." Professional Medical Journal 17, no. 04 (December 10, 2010): 557–62. http://dx.doi.org/10.29309/tpmj/2010.17.04.2960.
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Objectives: (1) To seek the association between chronic HCV infection and type 2 diabetes, mellitus. (2) To verify the effect of age, sex, socioeconomic status, obesity and presence of cirrhosis on the association of chronic HCV infection. Design. Case control study. Setting: DHQ Hospital, Faisalabad. Subjects: The subjects were divided into two groups. One was with positive anti-HCV antibody on ELISA method and other was without liver disease and negative for anti-HCV. Both the groups contained 500 subjects each and were selected according to the inclusion and exclusion criteria. Intervention: After a brief interview regarding age, residence, family history of diabetes, socioeconomic status, both the groups underwent weight and height measurements. The body mass was calculated according to the formulae. Ultrasonography of abdomen was done of all the patients of study groups to assess the liver status. Main outcome measures: Chi – squaretest was applied to see the association and then odds ratio was calculated to check the strength of association. Results: Diabetes mellitus was detected in 174 patients (34.8%) out of 500 patients in the group A as compared to 30 patients (6%) out of 500 patients in the group B. having chisquare value of 127.69 and significance of 0.000 with HCV +/ HCV- Odds ratio 0.120 and 95% CI0.079-0.181. Conclusions: There is strongassociation between HCV infection and type 2 diabetes mellitus. Severity of Liver Disease was strong associated factor.
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ELEFTHERIADIS, G., W. FRANK, and K. PETRAKAKIS. "40 Ar/39/Ar dating and cooling history of the Pangeon granitoids, Rhodope Massif (Eastern Macedonia, Greece)." Bulletin of the Geological Society of Greece 34, no. 3 (January 1, 2001): 911. http://dx.doi.org/10.12681/bgsg.17116.
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The Pangeon granitoids are distinguished into two pétrographie types with sharp contacts: (a) heterogranular, medium- to coarse-grained, hornblende+biotite- bearing porphyritic tonalités and granodiorites (PTG), and, (b) equigranular, medium-grained, biotite±muscovite-bearing granodiorites and granites (MGG). Dark-coloured, medium-grained monzodioritic enclaves occur in PTG rocks. Hornblende 40Ar/39Ar spectra from the PTG rocks yielded cooling ages of 21.7±0.5 Ma to 18.8±0.6 Ma. With the exception one sample, the corresponding hornblende ages from enclaves coincide well with the above ages. The age of 21.7±0.5 Ma is considered as the lower limit for the PTG rocks emplacement. Muscoviteplateau ages of c. 15.7±0.5 Ma and total gas biotite ages of 15.2±0.4 Ma to 13.8±0.5 Ma from the studied rocks, constrain the cooling history of the Pangeon granitoids (with some local variations) in the range 430 - 300Ί C.
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Fort, Joaquim, Toni Pujol, and Marc Vander Linden. "Modelling the Neolithic Transition in the Near East and Europe." American Antiquity 77, no. 2 (April 2012): 203–19. http://dx.doi.org/10.7183/0002-7316.77.2.203.
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AbstractFor the Neolithic transition in the Near East and Europe, this paper compares the isochrones predicted by computational models to those obtained by interpolating the archaeological data. This comparison reveals that there is a major inconsistency between the predictions of the models and the archaeological data: according to the models, the Neolithic front would have arrived to Greece in less than half the time interval implied by the data. Our main new results are as follows, (a) This inconsistency can be solved by including only Pre Pottery Neolithic B/C (PPNB/C) sites in the Near East; (b) the model that yields the lowest mean error per site in the arrival time of the Neolithic across the Near East and Europe is obtained by allowing for sea travels up to distances of 150 km; and (c) Mountain barriers have a negligible effect on the spread rate of the Neolithic front at the continental scale.
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Vakalopoulou, Sofia, Aristidis Slavakis, Maria Charizopoulou, Eirini Kazantzidou, Tania Chrysopoulou, Timoleon-Achilleas Vyzantiadis, Eleni Moka, Alexandra Agapidou, Vassilia Garipidou, and Panagiotis Anagnostis. "Reduced bone mineral density in patients with haemophilia A and B in Northern Greece." Thrombosis and Haemostasis 107, no. 03 (2012): 545–51. http://dx.doi.org/10.1160/th11-08-05563.
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SummaryHaemophilia A and B has been associated with increased prevalence of low bone mass (67–86%). The aim of this study was to estimate the prevalence of bone disease in haemophiliacs and its association with potential risk factors. Adult patients with haemophilia A and B followed-up in the Haemophilia Centre of Northern Greece were included. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry (DXA) in lumbar spine (LS), femoral neck (FN), total hip (TH) and great trochanter (GT). One-hundred four male patients (aged 45.8 ± 15.1 years) and 50 controls (aged 44.9 ± 12.8 years) were screened. Low BMD was diagnosed in 28 patients (26.9%) and 10 controls (20%) (p=0.0001). Patients had lower BMD in TH (p=0.007), FN (p=0.029) and GT (p=0.008) than controls, without differences in LS. BMD was positively associated with the severity of haemophilia, history of herpes virus C or human immunodeficiency virus and level of physical activity, and negatively with the level of arthropathy. In multiple-regression analysis, only the level of physical activity and 25-hydroxyvitamin D [25(OH)D] significantly predicted BMD. Half of the patients had vitamin D deficiency. In conclusion, our study showed increased prevalence of low BMD in haemophiliacs. The levels of physical activity and 25(OH)D independently predicted low BMD.
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Daniel, Elton L., Peter Christensen, and Steven Sampson. "The Decline of Iranshahr: Irrigation and Environments in the History of the Middle East, 500 B. C. to A. D. 1500." Journal of the American Oriental Society 116, no. 2 (April 1996): 336. http://dx.doi.org/10.2307/605758.
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Ponuzhdaev, E. A., and Tatiana A. Shpilkina. "«Roses» and «thorns» of the international division of labor: dialogue with history and modernity." Scientific notes of the Russian academy of entrepreneurship 19, no. 3 (September 20, 2020): 209–21. http://dx.doi.org/10.24182/2073-6258-2020-19-3-209-221.
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The authors considered historical and topical issues of the international division of labor (MRT). The analysis and parallel of MRI data by ancient scientists, researchers, scientists and experts of the XVIII, XIX, and XXI centuries. On the example of the European Union countries Greece, Spain and Portugal, the analysis of GDP, wages and unemployment as key indicators that characterize the economy of countries is carried out. The historical «cycle» of social structures is given and the dynamics of the ratio of the upper (B), middle (C) and lower (H) classes is shown.
It shows the current problems of world markets, taking into account sanctions, trade wars and the consequences of the pandemic. Prospects for the national division of labor (NDT) are defined.
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Nowak, M., S. Lacour, P. Mollière, J. Wang, B. Charnay, E. F. van Dishoeck, R. Abuter, et al. "Peering into the formation history of β Pictoris b with VLTI/GRAVITY long-baseline interferometry." Astronomy & Astrophysics 633 (January 2020): A110. http://dx.doi.org/10.1051/0004-6361/201936898.
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Context. β Pictoris is arguably one of the most studied stellar systems outside of our own. Some 30 yr of observations have revealed a highly-structured circumstellar disk, with rings, belts, and a giant planet: β Pictoris b. However very little is known about how this system came into being. Aims. Our objective is to estimate the C/O ratio in the atmosphere of β Pictoris b and obtain an estimate of the dynamical mass of the planet, as well as to refine its orbital parameters using high-precision astrometry. Methods. We used the GRAVITY instrument with the four 8.2 m telescopes of the Very Large Telescope Interferometer to obtain K-band spectro-interferometric data on β Pic b. We extracted a medium resolution (R = 500) K-band spectrum of the planet and a high-precision astrometric position. We estimated the planetary C/O ratio using two different approaches (forward modeling and free retrieval) from two different codes (ExoREM and petitRADTRANS, respectively). Finally, we used a simplified model of two formation scenarios (gravitational collapse and core-accretion) to determine which can best explain the measured C/O ratio. Results. Our new astrometry disfavors a circular orbit for β Pic b (e = 0.15−0.04+0.05). Combined with previous results and with HIPPARCOS/Gaia measurements, this astrometry points to a planet mass of M = 12.7 ± 2.2 MJup. This value is compatible with the mass derived with the free-retrieval code petitRADTRANS using spectral data only. The forward modeling and free-retrieval approches yield very similar results regarding the atmosphere of β Pic b. In particular, the C/O ratios derived with the two codes are identical (0.43 ± 0.05 vs. 0.43−0.03+0.04). We argue that if the stellar C/O in β Pic is Solar, then this combination of a very high mass and a low C/O ratio for the planet suggests a formation through core-accretion, with strong planetesimal enrichment.
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Akbar, Ali. "Effect Of Preheating On The Hardness And Microstructure In Shielded Metal Arc Weldments Of A283 B." R.E.M. (Rekayasa Energi Manufaktur) Jurnal 5, no. 2 (December 30, 2020): 29–35. http://dx.doi.org/10.21070/r.e.m.v5i2.1279.
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The purpose of this study was to determine the effect of heating on the welding process of SMAW (Shielded Metal Arc Welding) in terms of hardness and microstructure of welded metal. Much welding has been done by preheating but below the temperature used below the initial martensitic temperature which reaches 452 ° C, this data is sourced from research by S.Zheng et.al and Y. Huang et.al. For this reason, an experiment was carried out with heat temperatures above a martensitic temperature of 500 ° C. The results show that in the Weld Metal area the pearlite structure appears larger, the effect of current strength on HAZ width is directly proportional, the greater the current strength, the wider HAZ, and hardness are affected by the rough grains of martensite
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Judson, Anna P. "Orthographic variation as evidence for the development of the Linear B writing system." Written Language and Literacy 22, no. 2 (December 31, 2019): 179–97. http://dx.doi.org/10.1075/wll.00025.jud.
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Abstract This paper investigates the issue of orthographic variation in the Linear B writing system in order to explore ways in which studying a writing system’s orthographic conventions may shed light on the history of its development. Linear B was used in the palatial/administrative centres of Late Bronze Age Greece and Crete (c.1400–1200 B.C.E.) and records an early Greek dialect known as ‘Mycenaean’. The writing system’s structure and orthographic conventions permit flexibility in the spelling of particular phonological sequences: this paper discusses the varying orthographic representation of such sequences and shows that synchronic variation is common or even the norm in many cases. Investigating the factors which underlie this variation demonstrates the potential for a study of synchronic variation to illuminate a writing system’s diachronic development; it also underlines the importance of analysing the ways in which writers actually choose to use writing systems in order to fully understand their development.
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Touloumi, Giota, Argiro Karakosta, Vana Sypsa, Ioanna Petraki, Olga Anagnostou, Agis Terzidis, Niki Maria Voudouri, et al. "Design and Development of a Viral Hepatitis and HIV Infection Screening Program (Hprolipsis) for the General, Greek Roma, and Migrant Populations of Greece: Protocol for Three Cross-Sectional Health Examination Surveys." JMIR Research Protocols 9, no. 1 (January 31, 2020): e13578. http://dx.doi.org/10.2196/13578.
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Background Although infectious diseases are globally on the decline, they remain a major global public health problem. Among them, the hepatitis B virus (HBV) or hepatitis C virus (HCV) and HIV infection are of primary interest. Valid prevalence data on these infections are sparse in Greece, especially for vulnerable populations. Objective This study aimed to present the design and methods of Hprolipsis, an integrated viral hepatitis and HIV screening program administered to adults (≥18 years) from the general, Greek Roma, and migrant populations. Its aims were to estimate the prevalence of HBV, HCV, and HIV; assess infectious disease knowledge level; design, implement, and assess population-specific awareness actions; and offer individual counseling and referral when indicated and HBV vaccination to susceptible Roma and migrants. Methods Multistage, stratified, random sampling based on the 2011 Census was applied to select the general population sample, and nonprobability multistage quota sampling was used for Roma and migrant sample selection. Trained personnel made home (general population) or community (Roma and migrants) visits. Collected blood samples were tested for Hepatitis B surface Antigen, Hepatitis B core Antibody, Hepatitis B surface Antibody, Hepatitis C Antibody, and HIV 1,2 Antibody. The surveys were conducted during May 2013 and June 2016. To estimate an HCV prevalence of 1.5% with 0.3 precision, the required general population sample size was estimated to be 6000. As migrants constitute 10% of the whole Greek population, the migrant sample size was set to 600. A feasible sample size of 500 Greek Roma was set. Results In total, 6006 individuals from the general population (response rate 72%), 534 Greek Roma, and 612 migrants were recruited. Blood test results are available for 4245 individuals from the general population, 523 Roma, and 537 migrants. Conclusions Hprolipsis is the first nationwide survey on HBV, HCV, and HIV. Its results will enhance our understanding of the health needs and disease burden of these diseases in the 3 studied populations. Its implementation provided useful recommendations for future studies, particularly in vulnerable populations. International Registered Report Identifier (IRRID) DERR1-10.2196/13578
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Thakur, Shikha Singh, Shaheen Anjum, and S. S. Siddiqui. "Randomised controlled trial: comparing effects of metformin versus myoinositol versus metformin and myoinositol on ovarian functions and metabolic factors in polycystic ovarian syndrome." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 9, no. 6 (May 27, 2020): 2542. http://dx.doi.org/10.18203/2320-1770.ijrcog20202345.
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Background: Polycystic ovarian syndrome (PCOS) characterized by anovulation and features of hyperandrogenism (clinical or biochemical) and insulin resistance. Metformin and myoinositol being insulin sensitizers improve clinical and biochemical parameters. This study was done to compare the effects of these drugs on clinical features and biochemical profile.Methods: A randomized, comparative, clinical study was conducted on 72 patients. The patients were randomized with the help of computer-generated random numbers and were allocated to either of the three treatment groups A, B and C. Patients in group A received metformin 500 mg TDS, group B received myoinositol 1000 mg BD, group C received combination of metformin 500 mg and myoinositol 550 mg BD for 24 weeks. At first visit patients detailed history and baseline investigations were recorded. Follow up was done 24 weeks after start of therapy to assess the improvement in clinical and biochemical profile.Results: There was significant improvement in menstrual irregularities, cutaneous manifestations, pregnancy rate, LH/FSH ratio, insulin sensitivity and HOMA-IR after 24 weeks of treatment in all three groups (p value <0.05), although there was greater improvement in cases treated with combination of metformin and myoinositol than metformin and myoinositol alone.Conclusions: The combination of metformin and myoinositol has resulted in more significant reduction in insulin resistance and improvement in metabolic and hormonal profile along with regularization of menstrual cycles and spontaneous conception than metformin and myoinositol alone.
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Dagla, Maria, Irina Mrvoljak-Theodoropoulou, Despoina Karagianni, Calliope Dagla, Dimitra Sotiropoulou, Eleni Kontiza, Aikaterini-Taxiarchoula Kavakou, and Evangelia Antoniou. "Women’s Mental Health as a Factor Associated with Exclusive Breastfeeding and Breastfeeding Duration: Data from a Longitudinal Study in Greece." Children 8, no. 2 (February 17, 2021): 150. http://dx.doi.org/10.3390/children8020150.
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Background: This study investigated the relationship between exclusive breastfeeding and breastfeeding duration, and maternal psychological well-being in the perinatal period. Methods: A longitudinal study involving a retrospective follow-up of a group of 1080 women from pregnancy to the 1st year postpartum, who gave birth during the 5-year period between January 2014 and January 2019 in Athens, Greece, was designed. Women’s history and two psychometric tools—the Edinburg Postpartum Depression Scale (EPDS) and the Patient Health Questionnaire-9 (PHQ-9) administered at 5-time points—were used for data collection. Logistic regression analysis and a series of multiple analysis of variance (MANOVA) tests were performed. Results: The chance for exclusive breastfeeding (giving only breast milk) appeared to decrease (a) with an increase of the scores for psychometric tools antenatally (PHQ-9, p = 0.030) or at the 6th week postpartum (EPDS, p < 0.001 and PHQ-9, p < 0.001), (b) with an increase in the number of psychotherapeutic sessions needed antenatally (p = 0.030), and (c) when the initiation of psychotherapy was necessary postpartum (p = 0.002). Additionally, a shorter duration of any breastfeeding (with or without formula or other types of food/drink) seems to be associated with (a) the occurrence of pathological mental health symptoms (p = 0.029), (b) increased PHQ-9 scores antenatally (p = 0.018), (c) increased EPDS scores at the 6th week (p = 0.004) and the 12th month postpartum (p = 0.031), (d) the initiation of psychotherapy postpartum (p = 0.040), and e) the need for more than 13 psychotherapeutic sessions (p = 0.020). Conclusions: This study demonstrates a negative relationship between exclusive breastfeeding and breastfeeding duration, and poor maternal mental health in the perinatal period.
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Rhodes, P. J. "Central Greece in the Fourth Century - (J.) Buckler, (H.) Beck Central Greece and the Politics of Power in the Fourth Century B. C. Pp. xx + 309, maps. Cambridge: Cambridge University Press, 2008. Cased, £55 US$99. ISBN: 978-0-521-83705-7." Classical Review 60, no. 1 (March 8, 2010): 181–83. http://dx.doi.org/10.1017/s0009840x09990941.
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Smith, R., M. V. Karamouzis, D. E. Heron, R. L. Ferris, S. Y. Lai, S. Kim, T. Boyer, J. R. Grandis, J. T. Johnson, and A. Argiris. "Phase I trial of pemetrexed (P) in combination with cetuximab (C) and concurrent radiotherapy (RT) in patients (pts) with head and neck cancer (HNC)." Journal of Clinical Oncology 25, no. 18_suppl (June 20, 2007): 16516. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.16516.
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16516 Background: P is a multitargeted antifolate that has demonstrated activity in HNC and radiosensitizing properties in animal models. C is a chimeric IgG1 monoclonal antibody directed against the epidermal growth factor receptor that has increased the survival of pts with stage III/IV HNC when added to RT. We conducted a phase I study to evaluate the dose-limiting toxicities (DLT) and maximum tolerated dose of P when combined with standard RT and C. Methods: Pts with high-risk HNC were enrolled and evaluated separately in 2 cohorts: pts with no prior head and neck RT (cohort A) and previously irradiated pts (cohort B). A loading dose of C 400 mg/m2 was given intravenously 7 days prior to starting RT followed by 250 mg/m2 weekly throughout RT. RT was given 2 Gy/day to a total dose of 70 Gy (cohort A) or 60–66 Gy (cohort B). P was administered intravenously on days 1 and 22 (and day 43 if >60 Gy was delivered) according to the following design: Starting dose level (0)-350 mg/m2, dose level (-1)-200 mg/m2, dose level (+1)-500 mg/m2. Additional pts could be treated at a lower dose level while other pts were being evaluated at a higher dose level. Results: 18 pts have been enrolled (A: 14; B:4). 2 pts in cohort A were not evaluable and replaced (1 pt was noncompliant due to transportation issues and 1 pt had sudden death attributable to aspiration). Histological types: squamous cell (13), undifferentiated (1), medullary thyroid (1), adenoid cystic (1), and adenosquamous carcinomas (2). In cohort A, 2 DLT (both neutropenic fever with ANC <500) occurred: 1/6 at dose level 0 and 1/6 at dose level -1. In cohort B, no DLT has occurred: 0/3 pts at dose level 0 and 0/1 pts at dose level +1. There were no grade (G) 4 non- hematologic toxicities. Other serious toxicities included: neutropenic fever (NF) with ANC <1000 (n=1), G 3/4 neutropenia (n=3/n=4), G 3 dysphagia (n=5), G 3 dermatitis (n=3), G 3 mucositis (n=4), G 3 fatigue (n=1), and G 3 anemia (n=1). Due to the development of 3 cases of NF in cohort A the protocol was amended and prophylactic antibiotics were added. Conclusions: The addition of P to RT and C was feasible in pts with or without a history prior RT. Neutropenia and in-field toxicities were predominant but manageable. Pts are currently being treated at dose level +1 (P 500 mg/m2). No significant financial relationships to disclose.
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Palikidis, Angelos. "Why is Medieval History Controversial in Greece? Revising the Paradigm of Teaching the Byzantine Period in the New Curriculum (2018-19)." Espacio, Tiempo y Educación 7, no. 2 (July 7, 2020): 177–91. http://dx.doi.org/10.14516/ete.314.
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In which ways was Medieval and Byzantine History embedded in the Greek national narrative in the first life steps of the Greek state during the 19th century? In which ways has it been related to the emerging nationalism in the Balkans, and to relationships with the West and the countries of south-eastern Europe during the Balkan Wars, the First and Second World Wars, and especially the Cold War, until today? In which ways does Byzantium correlate with the notion of Greekness, and what place does it occupy in Neo-Hellenic identity and culture? Moreover, which role does it play in history teaching, and what kind of reactions does any endeavour of revision or reformation provoke? To answer the above questions I performed a comparative analysis on the following categories of sources: (a) Greek national and European historiography, (b) School history curricula and textbooks, (c) Public history sources, (d) The new History Curriculum for primary and secondary school classes, and (e) The principles and guidelines of international organizations such as the Council of Europe. In the first three sections of this paper, I provide an overview of the conformation and integration of the Byzantine period in Greek national historiography, in association with the dominant European philosophical and historical perspectives during the era of modernity, as well as the evolving national politics, foreign affairs, prevailing ideological schemas and the role of history teaching in shaping the common identity of the Neo-Hellenic society throughout the 19th and 20th centuries. The fourth section briefly deals with the current situation in history teaching in Greek schools, while the fifth section critically presents the innovative elements and features of the new History Curriculum, which, to some degree, aspires to be considered a paradigm shift in the teaching of Medieval History in school education. Finally, I summarize and draw several conclusions.
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Makedonas, Dimitrios, and Ken Hansen. "Diagnosis, Screening and Treatment of Root Resorption in Orthodontic Practices in Greece and Sweden." Angle Orthodontist 78, no. 2 (March 1, 2008): 248–53. http://dx.doi.org/10.2319/112006-468.1.
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Abstract Objective: To evaluate the perception of Greek and Swedish orthodontic practitioners regarding the possible occurrence and prognosis of root resorption occurring during orthodontic treatment and to estimate practitioners' approaches to the diagnosis of preexisting root resorption, screening of prevalence, and treatment planning approach when moderate or severe root resorption is present. Materials and Methods: Questionnaires were received from randomly selected Greek (n = 90) and Swedish (n = 106) practitioners. Topics of the questions included (a) the presence of history; (b) the radiographic evaluation of root resorption before, during, and after treatment; (c) the treatment approach of initial prevention and protocols in cases of radiographic diagnosis of root resorption during treatment. Results: Of the respondents, 47.1% of the Swedish practitioners and 32.3% of the Greek practitioners use periapical and panoramic radiographs to diagnose root resorption, mostly in the anterior region. Both groups recognize trauma, root form, and oral habits as predisposing factors. The majority of Swedish orthodontists perform radiographic follow-up in the first 6 months. In contrast, the Greek orthodontists perform it at 1 year or at the end of treatment. The treatment approach for root resorption that is most frequently used by Swedish orthodontists is altering the treatment plan, using light forces, and allowing resting periods, while the Greek orthodontists most frequently use lighter forces and reduce the total duration of the treatment. Conclusions: Because there is no specific approach offered in the literature, the prevention and treatment reassessment in cases of root resorption relies on individual practitioner perception.
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Bafiti, Tsabika, Maria Viou, and Prodromos Tarasis. "“Stepping up the ladder in safety”: An interpretative phenomenological analysis of how LGB clients experience their therapists’ sexual orientation." European Journal of Counselling Psychology 7, no. 1 (January 9, 2019): 211–23. http://dx.doi.org/10.5964/ejcop.v7i1.139.
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Relevant literature has explored the issue of disclosure of Lesbian, Gay and Bisexual (LGB) therapists to heterosexual or LGB clients. But how do homosexual or bisexual clients understand and experience their therapist’s heterosexual orientation, known or assumed, in relation to the therapeutic alliance and the therapeutic process? In this qualitative study, we used the Interpretative Phenomenological Analysis to examine eight semi-structured interviews with LGB clients in a family-oriented therapy in Greece. Analysis revealed two themes of higher order, each having three subordinate themes depicting the client’s experience of the therapist’s sexual orientation: 1. Focus on the therapist’s sexual orientation: (a) as a hypothesis (b) as a factor of acceptance (c) as a factor of professional capability and 2. Focus on other therapist features: (a) gender (b) personality traits (c) practice of professional role. The therapist’s sexual orientation or the one perceived by the client was not a neutral issue in therapy and the cultivation of the therapeutic relationship but was only one part of the process. The way all these issues were processed and approached by clients was related to their personal history and phase of therapy. Suggestions for future research include conducting a research on clients from different therapeutic perspectives since it was carried out only on participants in long-term systemic family therapy.
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Benekos, Thomas, Chrysoula Kosmeri, Antonios Vlahos, and Haralampos Milionis. "Nine-year overview of dyslipidemia management in children with heterozygous familial hypercholesterolemia: a university hospital outpatient lipid clinic project in Northwestern Greece." Journal of Pediatric Endocrinology and Metabolism 33, no. 4 (April 28, 2020): 533–38. http://dx.doi.org/10.1515/jpem-2019-0250.
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AbstractBackgroundTo assess the efficacy and safety of lipid-lowering treatment in children with heterozygous familial hypercholesterolemia (HeFH) aged ≤12 years attending a tertiary hospital-based outpatient lipid clinic.MethodsData in 318 children from the University Hospital of Ioannina (Northwestern Greece) Outpatient Lipid Clinic Project for Children and Adolescents with Dyslipidemia from March 2009 to December 2018 were analyzed. We assessed the efficacy and safety treatment alongside any possible predictors of the achievement of the treatment target.ResultsOf 318 children with hyperlipidemia, 72 were diagnosed having HeFH based on clinical criteria and genetic confirmation. Compared with non-familial hypercholesterolemia (non-FH) children, those with FH had a higher occurrence of positive family history of premature cardiovascular disease, and higher levels of total, low-density lipoprotein-cholesterol (LDL-C), apolipoprotein B (apoB) and lipoprotein (a) (Lp(a)). Treatment regimens included either atorvastatin 10–20 mg/day, rosuvastatin 5–10 mg/day, pitavastatin 2–4 mg/day monotherapy or in combination with ezetimibe. The treatment goal of LDL-C (<135 mg/dL, 3.5 mmol/L) was achieved in 69% of children treated. The achievement of the treatment targets correlated positively with male sex and inversely with the Dutch Lipid Clinic Network Score, baseline total, LDL-C and apoB levels. No clinically significant changes in liver or muscle-related laboratory tests were reported; no effect on growth or sexual maturation was noted.ConclusionsThis study confirms that lipid-lowering treatment in HeFH children initiated in the setting of a specialized tertiary hospital-based outpatient lipid clinic is efficacious and safe. Children of male sex and low baseline lipid values had a better achievement of treatment target.
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Konstantas, Alexander, Ioannis Karapanagiotis, and Stamatis C. Boyatzis. "Identification of Colourants and Varnishes in a 14th Century Decorated Wood-Carved Door of the Dionysiou Monastery in Mount Athos." Coatings 11, no. 9 (September 8, 2021): 1087. http://dx.doi.org/10.3390/coatings11091087.
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A decorated and carved wooden door of the late Byzantine period (14th Century), which belongs to the Dionysiou Monastery in Mount Athos, Greece, constitutes an important relic of valuable technological information due to its construction technology and history. Seventeen (17) samples detached from the door are studied using optical microscopy, scanning electron microscopy (SEM) with energy dispersive X-ray analysis (SEM-EDX), and micro-Raman and FTIR spectroscopy. The following materials are identified in the cross sections of the door samples using micro-Raman spectroscopy: orpiment, lead white, red lead, red ochre, cinnabar, carbon black, gypsum, anhydrite, and calcite, and an organic colourant of the indigoid family. SEM-EDX studies supported to the aforementioned Raman results. Interestingly, a combination of inorganic and organic colourants was detected. The main goals of this particular study were to: (a) reveal the colour palette and materials, (b) identify the type of varnish and its condition, and (c) contribute to future restoration processes and aid conservators in selecting compatible restoration materials.
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Surikov, Igor. "Nicknames among Greeks of the Archaic and Classical Periods: Preliminary Thoughts of a General Theoretical Nature." Akropolis: Journal of Hellenic Studies 2 (December 31, 2018): 5–19. http://dx.doi.org/10.35296/jhs.v2i0.33.
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This article is the first in a series devoted to nicknames of well-known people in Greece of pre-Hellenistic times. In it general considerations are primarily expressed about the role of nicknames in human societies (including ancient Greek), relations of nicknames to personal names and divine epithets, terminology of nicknames among the Greeks, and the possible reasons for not very broad development of the practice of nicknaming in Greece during this period.
A nickname is a fundamental phenomenon of the history of culture, and its real significance has not yet been appreciated. Nicknames in particular served as means of distinguishing individuals within any society. The names of the ancient Greeks had originally resembled nicknames as much as possible. Onomastic units in Greek poleis were mostly meaningful.
Nicknames can be assigned—not from a semantic but rather from an emotional point of view—to three basic types. We deal with nicknames of a) a positive, exalted character (“Olympian” as to Pericles); b) a negative, pejorative character (“Coalemos”—“Simpleton” as to Cimon the Elder); c) a neutral character—those that show a certain characteristic appearance of an individual (e.g., “One-Eyed”), or some kind of memorable detail of his biography (Hipponicus the “Ammon” in Athens at the turn of the 6th and 5th centuries BC).
Another interesting thing took place in pre-Hellenistic times. Nicknames were more often connected not with politicians and state figures but with people from cultural spheres—poets, philosophers.
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Μαντόγλου, Άννα. "Ελλάδα, διακύβευμα μνήμης και λήθης: περηφάνιας, τραύματος και ντροπής." Psychology: the Journal of the Hellenic Psychological Society 21, no. 3 (October 15, 2020): 262. http://dx.doi.org/10.12681/psy_hps.23280.
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The present study aims at exploring the role of age, gender, intra-national identification and political positioning in the recollection of the representational voluntary (=memory) and involuntary (=oblivion) historical-national past of Greece in conditions of pride, trauma and shame. In this experimental field study participated 254 men and women of different ages, who, after having read a text of a concise presentation of the Greek past -cutting off events either of pride, or of trauma and shame- noted three events that they wish to remember and three events that they wish to forget for ever from the Greek history. The interesting finding of the present study is associated with the emergence of four voluntary and involuntary organizing principles of thought about the historical past of Greece: a) a powerful and ruling memory, b) a regal memory of pride, c) a traumatical oblivion and, d) ashameful oblivion. The above ways of thinking are consensus and independent of the age, gender, political positioning and participants’ intra-national identification, as well. Any possible differences in perceiving the historical past concern individual variations rather than national collective concepts. This result is in line with the idea of a superior, urgent or regal national identity, which is constructed against other national identities and strategically «select» -institutionally and communicatively- to remember a positive, glorious, ruling and regal past, which makes ingroup members feel proud, while it decides not to communicate its traumatical (remedy oblivion) and, mainly, the shameful past (wormwood oblivion).
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Goldhill, Simon. "E. C. Keuls: Painter and Poet in Ancient Greece: Iconography and the Literary Arts. (Beiträge zur Altertumskunde, 87.) Pp. 430, 103 figs. Stuttgart and Leipzig: B. G. Teubner, 1997. ISBN: 3-519-07636-5." Classical Review 48, no. 1 (April 1998): 176–77. http://dx.doi.org/10.1017/s0009840x00331067.
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Yankova, Iskra, Miroslav Marinov, Boyko Neov, Maria Petrova, Nikolai Spassov, Peter Hristov, and Georgi Radoslavov. "Evidence for Early European Neolithic Dog Dispersal: New Data on Southeastern European Subfossil Dogs from the Prehistoric and Antiquity Ages." Genes 10, no. 10 (September 26, 2019): 757. http://dx.doi.org/10.3390/genes10100757.
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The history of dog domestication is still under debate, but it is doubtless the process of an ancient partnership between dogs (Canis familiaris) and humans. Although data on ancient DNA for dog diversity are still incomplete, it is clear that several regional dog populations had formed in Eurasia up to the Holocene. During the Neolithic Revolution and the transition from hunter-gatherer to farmer societies, followed by civilization changes in the Antiquity period, the dog population structure also changed. This process was due to replacement with newly formed dog populations. In this study, we present for the first time mitochondrial data of ancient dog remains from the Early Neolithic (8000 years before present (BP)) to Late Antiquity (up to 3th century AD) from southeastern Europe (the Balkans). A total of 16 samples were analyzed, using the mitochondrial D-loop region (HVR1). The results show the presence of A (70%) and B (25%) clades throughout the Early and Late Neolithic Period. In order to clarify the position of our results within the ancient dog population in Eneolithic Eurasia, we performed phylogenetic analysis with the available genetic data sets. This data showed a similarity of the ancient Bulgarian dogs to Italian (A, B, and C clades) and Iberian (clades A and C) dogs’ populations. A clear border can be seen between southern European genetic dog structure, on the one hand, and on the other hand, central-western (clade C), eastern (clade D) and northern Europe (clades A and C). This corresponds to genetic data for European humans during the same period, without admixture between dog populations. Also, our data have shown the presence of clade B in ancient Eurasia. This is not unexpected, as the B haplogroup is widely distributed in extant Balkan dogs and wolves. The presence of this clade both in dogs and in wolves on the Balkans may be explained with hybridization events before the Neolithic period. The spreading of this clade across Europe, together with the A clade, is related to the possible dissemination of newly formed dog breeds from Ancient Greece, Thrace, and the Roman Empire.
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NUONG, N. D., T. ITAYA, and Y. NISHIMURA. "Age (K–Ar phengite)–temperature–structure relations: a case study from the Ishigaki high-pressure schist belt, southern Ryukyu Arc, Japan." Geological Magazine 145, no. 5 (July 22, 2008): 677–84. http://dx.doi.org/10.1017/s0016756808004998.
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AbstractThe Ishigaki high-pressure schist belt in the southern Ryukyu Arc is correlated with the Suo high-pressure schist belt in southwest Japan. The former metamorphic sequence is composed mainly of basic and pelitic schists and is subdivided into three zones, the lower-grade zone A, the medium-grade zone B and the high-grade zone C, based on the mineral assemblages of the basic schists. The K–Ar phengite age gives 188–205 Ma for zone A, 196–206 Ma for zone B and 208–220 Ma for zone C, while the apparent d002 spacing of carbonaceous materials is 3.590–3.437 Å, 3.415–3.390 Å and 3.387–3.364 Å, respectively. The age–d002 relationships suggest that the ages become older with increasing metamorphic temperature. This positive age–temperature relationship in the Ishigaki area contrasts with a negative relationship in the Nishiki area in the Suo belt. The two areas also display a contrasting thermal structure with the former area having an inverted metamorphic gradient and the latter displaying a normal thermal structure. These contrasting age–temperature–structure relationships in the metamorphic belt could be due to different tectonic styles relating to the exhumation of the metamorphic sequences. We suggest that the ages obtained are related directly to the ductile deformation history of the matrix phengite below the closure temperature (500°C) during exhumation of the host rocks. The duration from the beginning of exhumation to the apparent resetting of the phengite K–Ar system was different between the two metamorphic sequences, and significantly longer in the Ishigaki than the Nishiki.
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Sokol, Alexander G., Alexander F. Khokhryakov, Yuri M. Borzdov, Igor N. Kupriyanov, and Yuri N. Palyanov. "Solubility of carbon and nitrogen in a sulfur-bearing iron melt: Constraints for siderophile behavior at upper mantle conditions." American Mineralogist 104, no. 12 (December 1, 2019): 1857–65. http://dx.doi.org/10.2138/am-2019-7103.
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Abstract Carbon solubility in a liquid iron alloy containing nitrogen and sulfur has been studied experimentally in a carbon-saturated Fe-C-N-S-B system at pressures of 5.5 and 7.8 GPa, temperatures of 1450 to 1800 °C, and oxygen fugacities from the IW buffer to log fO2 ΔIW-6 (ΔIW is the logarithmic difference between experimental fO2 and that imposed by the coexistence of iron and wüstite). Carbon saturation of Fe-rich melts at 5.5 and 7.8 GPa maintains crystallization of flaky graphite and diamond. Diamond containing 2100–2600 ppm N and 130–150 ppm B crystallizes in equilibrium with BN within the diamond stability field at 7.8 GPa and 1600 to 1800 °C, while graphite forms at other conditions. The solubility of carbon in the C-saturated metal melt free from nitrogen and sulfur is 6.2 wt% C at 7.8 GPa and 1600 °C and decreases markedly with increasing nitrogen. A 1450–1600 °C graphite-saturated iron melt with 6.2–8.8 wt% N can dissolve: 3.6–3.9 and 1.4–2.5 wt% C at 5.5 and 7.8 GPa, respectively. However, the melt equilibrated with boron nitride and containing 1–1.7 wt% sulfur and 500–780 ppm boron dissolves twice less nitrogen while the solubility of carbon remains relatively high (3.8–5.2 wt%). According to our estimates, nitrogen partitions between diamond and the iron melt rich in volatiles at DNDm/Met=0.013−0.024. The pressure increase in the Fe-C-N system affects iron affinity of N and C: it increases in nitrogen but decreases in carbon. The reduction of C solubility in a Fe-rich melt containing nitrogen and sulfur may have had important consequences in the case of imperfect equilibration between the core and the mantle during their separation in the early Earth history. The reduction of C solubility allowed C supersaturation of the liquid iron alloy and crystallization of graphite and diamond. The carbon phases could float in the segregated core liquid and contribute to the carbon budget of the overlying silicate magma ocean. Therefore, the process led to the formation of graphite and diamond, which were the oldest carbon phases in silicate mantle.
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Marshall, Helen S., Mark McMillan, Ann Koehler, Andrew Lawrence, Jenny MacLennan, Martin Maiden, Mary Ramsay, et al. "B Part of It School Leaver protocol: an observational repeat cross-sectional study to assess the impact of a meningococcal serogroup B (4CMenB) vaccine programme on carriage ofNeisseria meningitidis." BMJ Open 9, no. 5 (May 2019): e027233. http://dx.doi.org/10.1136/bmjopen-2018-027233.
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IntroductionInvasive meningococcal disease is uncommon but associated with a high-case fatality rate. Carriage prevalence of the causative bacteria,Neisseria meningitidis, is high in adolescents. A large (n=34 500) cluster randomised controlled trial (RCT) to assess the impact of a meningococcal B (MenB) vaccine on meningococcal carriage was implemented in the state of South Australia (SA) for year 10, 11 and 12 senior school students in 2017–2018. This study will assess the impact of MenB vaccine (4CMenB) on carriage prevalence in school leavers in SA, 1 and 2 years after implementation of the cluster RCT in adolescents. Measuring the impact of population programmes on carriage can assist in informing future meningococcal immunisation programmes such as targeted age groups and use of catch-up campaigns.Methods and analysisThis repeat cross-sectional study will assess carriage prevalence in 2018 and 2019. All school leavers who attended year 12 in any school in SA in 2018 or 2019 will be invited to participate in this study. An oropharyngeal swab will be taken from each participating student and a risk factor questionnaire completed by the student following informed consent. Students will attend clinics at SA universities, technical colleges, and metropolitan, rural and remote government council clinics. Confirmed vaccination history will allow a comparison in carriage prevalence between vaccinated and unvaccinated school leavers. A sample size of 4096 students per year will provide 80% power to detect a 20% difference in carriage prevalence of disease-causing meningococci (defined as genogroup A, B, C, W, X or Y) between years.Ethics and disseminationThe study was approved by the Women’s and Children’s Health Network Human Research Ethics Committee. Results will be published in international peer review journals and presented at national and international conferences.Trial registration numberNCT03419533; Pre-results
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Aldridge, Robert W., Andrew C. Hayward, Sara Hemming, Susan K. Yates, Gloria Ferenando, Lucia Possas, Elizabeth Garber, et al. "High prevalence of latent tuberculosis and bloodborne virus infection in a homeless population." Thorax 73, no. 6 (January 29, 2018): 557–64. http://dx.doi.org/10.1136/thoraxjnl-2016-209579.
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IntroductionUrban homeless populations in the UK have been shown to have high rates of active tuberculosis, but less is known about the prevalence of latent tuberculosis infection (LTBI). This study aimed to estimate the prevalence of LTBI among individuals using homeless hostels in London.MethodsWe performed a cross-sectional survey with outcome follow-up in homeless hostels in London. Our primary outcome was prevalence of LTBI. Recruitment for the study took place between May 2011 and June 2013. To estimate an LTBI prevalence of 10% with 95% CIs between 8% and 13%, we required 500 participants.Results491/804 (61.1%) individuals agreed to be screened. The prevalence of LTBI was 16.5% (81/491; 95% CI 13.2 to 19.8). In UK-born individuals, a history of incarceration was associated with increased risk of LTBI (OR 3.49; 95% CI 1.10 to 11.04; P=0.018) after adjusting for age, length of time spent homeless and illicit drug use. Of the three subjects who met English treatment guidelines for LTBI at the time of the study, none engaged with services after referral for treatment. Prevalence of past hepatitis B infection was 10.4% (51/489; 95% CI 7.7 to 13.1), and 59.5% (291/489; 95% CI 55.1 to 63.9) of individuals were non-immune. Prevalence of current hepatitis C infection was 10.4% (51/489; 95% CI 7.8 to 13.1).ConclusionsThis study demonstrates the high prevalence of LTBI in homeless people in London and the associated poor engagement with care. There is a large unmet need for LTBI and hepatitis C infection treatment, and hepatitis B vaccination, in this group.
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Tsakirgis, Barbara. "Style and Society in Dark Age Greece: The Changing Face of a Pre-literate Society 1100-700 B. C. James Whitley. New Studies in Archaeology. Cambridge University Press, Cambridge, 1991. xix + 225 pp., plates, figures, tables, bibliography, indexes. No price given." American Antiquity 58, no. 4 (October 1993): 768–69. http://dx.doi.org/10.2307/282216.
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Mandala, Eudokia, Christos Lafaras, Theodoros Dardavesis, Mattheos Speletas, Dimitrios Platogiannis, Constantina Tsioni, Eudoxia Douvleti, and George Ilonidis. "Prevalence of Thrombophilia Genes in Patients with Idiopathic Thromboembolic Disease." Blood 110, no. 11 (November 16, 2007): 1644. http://dx.doi.org/10.1182/blood.v110.11.1644.1644.
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Abstract Thromboembolic disease (TED) is one of the main reasons of morbitity and mortality. Its manifestations are acute coronary syndromes (ACS), PE, DVT and ischemic cerebrovascular disease (CVD). Inherited thrombophilia’s contribution to arterial thrombosis is still controversial. Aim: investigation of thrombophilia genes’ prevalence (FV Leiden G1691A-FVL, FII G20210A), and homocystein metabolism (MTHFR polymorphism C677T), in patients with documented idiopathic TED (ITED), comparison between venous, arterial and mixed episodes and correlation with acquired factors (dyslipidemia, smoking and homocysteine). 774 patients, 515 fulfilling the criteria of ITED, 50.8% males, 15–68 years (median age 44), were studied in Northern Greece. Patients were divided into three groups: 258 (50.1%) had venous thrombosis (group A), 239 (46.4%) with arterial (group B) and 18 (3.5%) had mixed episodes (Group C). They filled detailed questionnaire, personal and family history, origin, smoking. Antithrombin, protein C, S, APCR, homocystein and antiphospholipid antibodies were measured. Lipid profile was determined. Molecular assessment of FVL, FII, and MTHFR were performed. Genetic defect was detected in 82.7% in group A, 81.9% in group B and 66.7% in group C. Patients with venous TED were positive for FVL in 39.8% (37.2% heterozygous and 2.6% homozygous), 28.4% positive for FII (26.9% and 1.5% respectively) and 42.2% had MTHFR (34.9% and 7.3% respectively). Combined genetic defects were found in 27.7% of group A (25.3% double, 2.4% triple). Patients with arterial disease were heterozygous for FVL in 37.3%, 6.65% heterozygous for FII and 62.3% had MTHFR (48% heterozygous and 14.3% homozygous). Combined genetic defects were found in 18.6% in group B (17.4% double, 1.2% triple). Patients with mixed TED were heterozygous for FVL in 33.3%, nobody had FII and 83.3% MTHFR (50% heterozygous and 33.3% homozygous), combined defects1.2%. Number of positive and negative for FVL patients did not have any statistically significant difference between groups A and B (x2=0,097; p=0.440). Number of positive and negative for FII patients revealed statistically significant difference among three groups, with significant increase in venous disease (x2=12.009; p=0.001). Number of positive and negative for MTHFR had statistically significant difference between groups A and B, with increase in arterial disease (x2=3.410; p=0.05). Population studied was homogenous, as regards age (one way ANOVA, p=0.943), lipid profile (x2=2.611; p=0.271), smoking (x2=1.490; p=0.506), homocystein levels (x2=3.458; p=0.177) and positive family history (x2=4.490; p=0.099). Significant correlation of FII with venous TED and statistically significant increase in MTHFR prevalence in arterial TED was found. It is known that FVL is associated with increased risk of venous TED. There was no difference in prevalence of FVL between venous and arterial disease, demonstrating that it is associated with arterial disease, too. So, young patients with arterial events (ACS and/or CVD) should undergo thrombophilia testing including FVL. Nowadays, combined (double or triple) genetic defects are frequently detected (22.9% of our cases). Identification of these mutations is important in the overall assessment and management of patients at high risk.
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Assing, Volker. "Monograph of the Staphylinidae of Crete (Greece). Part I. Diversity and endemism (Insecta: Coleoptera)." Beiträge zur Entomologie = Contributions to Entomology 69, no. 2 (December 23, 2019): 197–239. http://dx.doi.org/10.21248/contrib.entomol.69.2.197-239.
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With a geological history of long isolation, fragmentation, partial submersion, and subsequent rising, characterized by a remarkable diversity in topology, geology, and habitats, and the fifth-largest island of the Mediterranean, Crete has provided an ideal setting for speciation and developing a unique and diverse Staphylinidae fauna. Although beginning already in the middle of the 19th century, the exploration of this fauna gained momentum only recently. Based on a critical revision of literature data, on material collected during several recent field trips, and on additional previously unpublished records, a checklist of the Staphylinidae of Crete is compiled, including as many as 397 named species, with 115 of them reported from the island for the first time and with 48 new species described in the second part of the monograph. Additional unidentified and unnamed species, as well as species doubtfully or erroneously recorded from Crete are listed separately. The systematic, zoogeographic, and ecological composition of the Staphylinidae fauna is characterized with a special focus on the endemics. The latter are represented by 111 named and at least ten unnamed species, account for nearly one-third of the fauna, and mainly belong to the subfamilies Aleocharinae, Scydmaeninae, Pselaphinae, Paederinae, Leptotyphlinae, Staphylininae, and Omaliinae. More than half of them are even locally endemic. The genera with the greatest number of endemic species are Cephennium Müller & Kunze, 1822 of the Scydmaeninae (twelve named species) and Geostiba Thomson, 1858 of the Aleocharinae (nine named species). More than two-thirds of the endemic species are epigeic inhabitants of forests, bush and shrub habitats, grassland, and wetlands, approximately one-fourth is confined to deeper soil strata or endogean, and 8 % are myrmephilous. Slightly more than half (59 species; 53 %) of the endemics are most likely the result of in-situ radiation (18 lineages), the remainder of vicariance with mainland species. A comparison with other Mediterranean islands revealed that (a) total diversity of the Cretan fauna is significantly greater than that of other East Mediterranean islands except Corfu, but much lower than that of Corsica, Sardinia, and Sicily, (b) regarding the number of endemic species Crete ranks third behind Corsica and Sardinia, and (c) the rate of endemism is greater in Crete than in any other Mediterranean island. Explanations for the observed differences in the diversity and composition of the faunas of the islands are discussed. Stichoglossa graeca Bernhauer, 1905, a species of which previously only the lectotype was known, is redescribed and illustrated. Six synonymies are proposed and one name is revalidated: Phloeocharis longipennis Fauvel, 1875 = P. hummleri Bernhauer, 1915, syn. nov.; Phytosus balticus Kraatz, 1859 = P. holtzi Bernhauer, 1935, syn. nov.; Atheta nigra (Kraatz, 1856) = A. biroi Scheerpeltz, 1964, syn. nov.; Domene stilicina (Erichson, 1840) = D. lohseiana Bordoni, 1977, syn. nov.; Oedichirus rubronotatus Pic, 1903, revalidated = O. reitteri Bernhauer, 1908, syn. nov.; Pseudolathra quadricollis (Fauvel, 1875) = P. cretensis Bordoni, 1986, syn. nov. A lectotype is designated for Stichoglossa graeca Bernhauer, 1905. Two species are reported from Greece for the first time.
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Rotroff, Susan I. "A HISTORY OF GREEK ART AND ARCHAEOLOGY - R.T. Neer Art & Archaeology of the Greek World. A New History, c. 2500–150 bce. Pp. 400, b/w & colour ills, colour maps. London: Thames & Hudson, 2012. Cased, £35. ISBN: 978-0-500-05166-5." Classical Review 63, no. 1 (March 1, 2013): 225–26. http://dx.doi.org/10.1017/s0009840x12003137.
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Chodubski, Andrzej. "Jedność europejska: wizje i sposoby urzeczywistniania integracji." Przegląd Politologiczny, no. 2 (November 2, 2018): 7–20. http://dx.doi.org/10.14746/pp.2012.17.2.1.
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The idea of European unity is a political challenge that has been addressed in various forms since the states started forming in the vicinities of the Rhine, Danube and Elbe. In the course of history European integration has evolved to face the challenges of a) merging, crossing and diffusion of cultural patterns represented by different local, regional and supra-regional communities; b) the submission or conquests of regions by empires and imposing defined patterns of cultural life on them; c) the reinforcement of the continental identity vis à vis other civilizations, in particular Asiatic ones; d) the guarantee of safety for states and nations as well as the promotion of the ideas of liberty, the rule of law, self-governance and democracy. In creating the spiritual unity of Europe, the repertoire of values developed by the cultural life of ancient Greece and Rome, as well as Judeo-Christian communities, is commonly referred to. European identity is characterized by a division into cultural and political identification. The idea of European unity is both an intellectual, and a theoretical-doctrinal concept, oriented at the broadest range of cultural and civilizational integration of the continent, as well as a concrete political and economic undertaking. At present, particular significance is attached to the attitude of public opinion when implementing it. The Union’s integration is an aspect of numerous implementation projects which depends on the support and legitimization of public opinion.
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Traina, Fabiola, Stefano G. Jorge, Ademar Yamanaka, Fernando F. Costa, and Sara T. O. Saad. "Sickling Process as the Major Cause of Sickle Cell Hepatopathy: A Clinicopathologic Study of 70 Living Patients." Blood 104, no. 11 (November 16, 2004): 1681. http://dx.doi.org/10.1182/blood.v104.11.1681.1681.
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Abstract Sickle cell hepatopathy encompasses a range of hepatic pathologies arising from a wide variety of insults to the liver in patients with sickle cell disease (SCD). Much of the literature on sickle cell hepatopathy lacks depth, since few sizeable or controlled studies are available, and most studies provide incomplete information regarding coexisting chronic infection with hepatitis B or C and hepatic iron deposition. Previous reports in living patients are rare and concern a limited number of cases. The present study aimed to evaluate the contributing effects of these various insults to the final pathologic and clinical picture in these patients. Clinical, biochemical, serological and abdominal ultrasound findings were analyzed prospectively in 70 patients diagnosed with SCD (36 females and 34 males, mean age of 27, range 9–56 years) from the Hematology and Hemotherapy Center of the State University of Campinas. The SCD types were distributed as follows: 57 HbSS, 6 HbSC, 2 HbSB0, 5 HbSB+. The study was approved by the National Ethical Committee Board and informed-written consent was obtained from all patients. The inclusion criteria for this study were a precise clinical and laboratory diagnosis of SCD and regular follow-up in the clinic. All patients were submitted to laboratory tests and to abdominal ultrasound. Abdominal ultrasound and image analyses were simultaneously performed by two gastroenterologists (SGJ and AY). Liver biopsies were obtained in those patients with diagnosis of hepatopathy and who were in agreement with the procedure. Hepatopathy was defined as abnormal plasma alanine transaminase (ALT) and/or cirrhosis or chronic hepatopathy detected by abdominal ultrasound. Hepatitis C was defined as a positive serum for anti-HCV antibody. Hepatitis B was defined as seropositivity for hepatitis B surface antigen (HbsAg) with a negative serum for hepatitis B surface antibody. Hemosiderosis was defined as ferritin level above 500 ng/ml and history of chronic transfusion. According to this definition, 36 of the 70 (51%) patients had hepatopathy. The cause for hepatopathy was hepatitis C or B in 4 patients, hemosiderosis in 8 patients and both in 3 patients. The reason for hepatopathy in the remaining 21 (58%) patients was justified only by the sickling process. Excluding all patients with hepatitis B or C and/or hemosiderosis, in a Wilcoxon rank-sum test, the diagnosis of hepatopathy was not associated with age, hemoglobin, leukocytes, platelets and fetal hemoglobin level; in a Fisher’s exact test the diagnosis of hepatopathy was not associated with sex, race, presence of alpha thalassemia, cholelithiasis, alcohol use, hepatotoxic drugs and diabetes. A liver biopsy was obtained in 12 of 36 patients with diagnosis of hepatopathy. In the group of patients without hepatitis and/or hemosiderosis, the pathological findings consisted of sinusoidal dilatation, intrasinusoidal congestion, portal fibrosis, pericellular fibrosis and focal necrosis. In the group with hepatitis, the pathological findings were the same. In the group with hemosiderosis, the pathological findings included those previously described in addition to hemosiderosis. These results showed that, in patients with SCD, hepatopathy is frequent and in most cases explained only by the sickling process.
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Kolomiets, T., O. Skatenok, A. Alexandrova, Z. Mukhina, T. Matveeva, D. Bogomaz, D. K. Berner, and C. A. Cavin. "First Report of Anthracnose of Salsola tragus Caused by Colletotrichum gloeosporioides in Russia." Plant Disease 92, no. 9 (September 2008): 1366. http://dx.doi.org/10.1094/pdis-92-9-1366b.
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In October of 2006, dying Salsola tragus L. (Russian thistle, tumbleweed), family Chenopodiaceae, plants were found along the Azov Sea at Chushka, Russia. Approximately 40 plants in the area were diseased and almost 80% of these were dying. Plants were approximately 1 m tall × 0.5 m wide. Dying plants had irregular, necrotic lesions along the length of the stems. Leaves of these plants were also necrotic. Lesions on stems and leaves were dark brown and usually coalesced. Diseased stems were cut into 3- to 5-mm pieces, disinfested in 70% ethyl alcohol, and then placed onto the surface of potato glucose agar (PGA). Numerous, waxy, subepidermal acervuli with 110 μm long (mean) black setae were observed in all of the lesions after 2 to 3 days. Conidiophores were simple, short, and erect. Conidia were one-celled, hyaline, ovoid to oblong, falcate to straight, and measured 12.9 to 18.0 × 2.8 to 5.5 μm (mean 15.6 × 4.2 μm). Appressoria formed 24 h after placing conidia on a dialysis membrane over 20% V8 juice agar. Appressoria measured 4.0 to 13.9 × 2.4 to 8.8 μm (mean 7.0 × 5.2 μm). These characters conformed to the description of Colletotrichum gloeosporioides (Penz.) Penz. & Sacc. in Penz. (1). A voucher specimen was deposited with the U.S. National Fungus Collections, Beltsville, MD (BPI 878389). Nucleotide sequences for the internal transcribed spacers (ITS 1 and 2) were deposited in GenBank (Accession No. EU530697) and aligned with ITS sequences of two other isolates from S. tragus. There was 100% similarity to each isolate, one from Greece (Accession No. DQ344621) and one from Hungary (Accession No. EU805538). Axenic cultures on PGA were sent to the Foreign Disease-Weed Science Research Unit, USDA, ARS, Fort Detrick, MD for testing in quarantine. Conidia were harvested from 14-day-old cultures grown on 20% V8 juice agar, and healthy stems and leaves of 30-day-old plants of S. tragus (13 plants) were spray inoculated with an aqueous conidial suspension of 1.0 × 106 conidia/ml plus 0.1% v/v polysorbate 20. Another 13 control plants were sprayed with water and surfactant without conidia. Plants were placed in an environmental chamber at 100% humidity for 16 h in the dark at 25°C. After approximately 24 h, all plants were transferred to a greenhouse at 20 to 25°C, 30 to 50% relative humidity, and natural light augmented by 12-h light periods with 500 W sodium vapor lights. Lesions developed on stems of all inoculated plants after 7 days. After 14 days, nine plants were dead and all inoculated plants were dead after 3 weeks. No symptoms developed on control plants. C. gloeosporioides was reisolated from stem pieces of all inoculated plants, and the morphology of the reisolated pathogen was the same as that of the initially isolated pathogen. To our knowledge, this is the first report of anthracnose caused by C. gloeosporioides on S. tragus in Russia. Reference: (1) B. C. Sutton. Page 15 in: Colletotrichum Biology, Pathology and Control. J. A. Bailey and M. J. Jeger, eds. CAB International, Wallingford, UK, 1992.
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Ixer, Robert. "The Stone of Life: querns, mills and flour production in Europe up to c AD 500. By David Peacock. 244mm. Pp xvi + 220, 100 col and b&w ills. Southampton Monogr Archaeol new ser 1, The Highfield Press, Southampton, 2013.isbn9780992633608. £45 (hbk)." Antiquaries Journal 96 (August 11, 2016): 432–34. http://dx.doi.org/10.1017/s0003581516000329.
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Platzbecker, Uwe, Anne Sophie Kubasch, Aristoteles Giagounidis, Georgia Metzgeroth, Anna Jonasova, Regina Herbst, Jose Miguel Torregrosa Diaz, et al. "Biomarkers of Response to Romiplostim in Patients with Lower-Risk Myelodysplastic Syndrome (MDS) and Thrombocytopenia - Results of the Europe Trial By the Emsco Network." Blood 134, Supplement_1 (November 13, 2019): 2998. http://dx.doi.org/10.1182/blood-2019-129047.
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Introduction: Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis and peripheral cytopenia. In about half of patients with lower-risk (LR) MDS, thrombocytopenia is present at the time of diagnosis and associated with shortened survival and an increased risk of progression to acute myeloid leukemia (AML). The thrombopoietin receptor agonist (TPO-RA) romiplostim has shown safety and marked efficacy in a still poorly-defined subset of LR-MDS patients with thrombocytopenia. Methods: The EUROPE multicenter phase 2 trial within the EMSCO network investigated the impact of biomarkers like endogenous thrombopoietin (TPO) level and platelet transfusion events (PTE) on the efficacy of romiplostim (750µg SC qw) treatment in patients with LR-MDS (IPSS low/int-1). Patients were eligible if baseline bone marrow blast count was <5% as assessed by central morphology and platelet counts were ≤30 Gpt/L or ≤50 Gpt/L in case of bleeding history. According to a previously published model of response to TPO-RA (Sekeres at al. BJH 2014), patients were assigned into 3 different cohorts at the time of screening based on their previous PTE as well as centrally assessed TPO serum levels (cohort A: TPO<500 ng/l, PTE<6 units/past year; cohort B: TPO<500 ng/l, PTE≥6 units or TPO≥500 ng/l, PTE<6 units, cohort C: TPO≥500 ng/l, PTE≥6 units). Primary endpoint of the study was the rate of hematologic improvement of platelets (HI-P) according to IWG 2006 criteria after 16 weeks of romiplostim treatment. We here present the analysis for the first 16 weeks of romiplostim treatment. Results: From 2015 to 2018, a total of 68 patients were included in 20 trial sites in Germany, France and Czech Republic. Patients displayed a median age of 74 years and a median platelet count of 25 G/L (range 1-50 G/L) and were stratified into cohort A (n=47), B (n=17) or C (n=4), respectively. All patients received at least one cycle of romiplostim with a median weekly dose of 750μg and a median of 15 cycles of romiplostim until week 16. Reasons for premature study discontinuation before week 16 were investigator/patient decision (n=8), adverse events (n=5), disease progression (n=4) or death (n=1). There were 9 reported severe treatment-related adverse events in seven patients including pulmonary embolism (n=1), subacute stroke (n=1), mucocutaneous hemorrhage (n=1), asthenia (n=1), suspicion of anti-romiplostim antibodies (n=1), progression to AML (n=1) and varicella zoster infection (n=1). Two patients had transient increases in peripheral blasts to more than 10% and 1 patient progressed to AML after 1 month of treatment. HI-P was observed in 26 of 68 (38%) patients, while response was ongoing in 24 of them beyond week 16. Moreover, rate of HI-P lasting for at least 8 weeks was notably higher in cohort A (45%, n=21/47) compared to patients in cohort B and C (24%, n=5/21) (p=0.11). Median peak increase of PLT count in responding patients was 199 G/L in cohort A and 83 G/L in cohort B (p=0.25) and was observed in median after 7 weeks (range 3-16). In addition, responses occurred also in 2 patients in the neutrophil (HI-N) and in 7 patients in the erythroid (HI-E) lineage according to IWG 2006 criteria (Table 1). Explorative analysis showed a correlation between pretreatment platelet transfusion requirement and endogenous TPO-levels (spearman-test, p=0.034). Median pretreatment endogenous TPO-level was lower in responders compared to non-responders (82 vs. 103 pg/ml, p=0.15). Higher response rates occurred in patients with lower TPO-levels (<500 ng/l) and lower pre-treatment transfusion needs (PTE<6 units/past year), but both variables were not significantly associated with response to romiplostim (univariable logistic regression, p= 0.13 and p=0.53, respectively). Evaluation of the mutational profile in a subgroup of 49 patients demonstrated that 67% of responders exhibited spliceosome mutations including SRSF2, SF3B1, U2AF1 and ZRSR2 compared to 35% in non-responders (p=0.06) (Table 1). Conclusion: This prospective study confirms that romiplostim treatment is highly effective in a subgroup of LR-MDS patients, but neither baseline platelet transfusion requirements nor baseline TPO levels were significantly associated with clinical response to romiplostim. Further translational analyses are ongoing to elucidate potential biomarkers of response. Disclosures Platzbecker: Celgene: Consultancy, Honoraria; Novartis: Consultancy, Honoraria; Abbvie: Consultancy, Honoraria. Götze:AbbVie: Membership on an entity's Board of Directors or advisory committees. Cony-Makhoul:Pfizer: Consultancy; Novartis: Consultancy; Incyte Biosciences: Honoraria, Speakers Bureau; BMS: Consultancy, Honoraria, Speakers Bureau. Park:Celgene: Membership on an entity's Board of Directors or advisory committees, Research Funding. Thiede:Daiichi Sankyo: Honoraria; Novartis: Consultancy, Honoraria, Research Funding, Speakers Bureau; AgenDix GmbH: Employment, Equity Ownership; Diaceutics: Membership on an entity's Board of Directors or advisory committees. Ades:Helsinn Healthcare: Membership on an entity's Board of Directors or advisory committees; Celgene: Membership on an entity's Board of Directors or advisory committees; Novartis: Membership on an entity's Board of Directors or advisory committees; Takeda: Membership on an entity's Board of Directors or advisory committees; Silence Therapeutics: Membership on an entity's Board of Directors or advisory committees; Agios: Membership on an entity's Board of Directors or advisory committees; Jazz: Membership on an entity's Board of Directors or advisory committees; Abbvie: Membership on an entity's Board of Directors or advisory committees; Astellas: Membership on an entity's Board of Directors or advisory committees; Amgen: Research Funding. OffLabel Disclosure: Romiplostim is formally not licensed for the treatment of thrombocytopenia due to myelodysplastic syndrome (MDS).
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Jalil, MA, MA Samad, and MT Islam. "EVALUATION OF MATERNALLY DERIVED ANTIBODIES AGAINST NEWCASTLE DISEASE VIRUS AND ITS EFFECT ON VACCINATION IN BROILER CHICKS." Bangladesh Journal of Veterinary Medicine 7, no. 2 (September 3, 2010): 296–302. http://dx.doi.org/10.3329/bjvm.v7i2.5995.
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The study was conducted to determine the persistence of maternally derived antibody (MDA) and its effects on protection against NDV in broiler chickens and to investigate the status of humoral immune response following vaccination with BCRDV® (F-strain, lentogenic) at different ages of broiler chickens during the period from August to October, 2008. A total of 90 day-old broiler chicks of Cobb 500 strain with the history of vaccination of parent stock against Newcastle disease (ND) was divided into three groups (A, B and C). Birds of group A (n = 35) were used for the study of protection ability of MDA against NDV, the birds of group B (n = 45) were used for the measurement of humoral immune response in chickens following vaccination at different ages and birds of group C (n = 10) were used for the determination of persistence of maternally derived antibody. The level of antibody titre against NDV was determined by HI test. The protective potentiality of MDA and vaccine was determined by the rate of survivability of the chickens following challenge infection. It was observed that the MDA titre in day-old chicks was higher and gradually declined at minimal level at day 28. The MDA titre of 128 or above protected the birds following challenge infection with virulent NDV. There were significant decrease in HI titres of chickens which were vaccinated once at day 1 and day 7, and could not withstand challenge infection with virulent NDV. Single vaccination with BCRDV® at day 14 triggered the production of antibody but could not provide complete protection to the birds. The birds which were boosted with the same vaccine 7 days and 21 days after primary vaccination produced better immune response. However, the birds which were vaccinated primarily at day 1 and boosted at day 7 could not withstand the challenge completely. Of the other regimens of twice vaccination, primary vaccination at day 7 and booster dosing at day 28 was found to be the best in terms of immune response and protection potentiality. Therefore, it may be concluded that (a) The MDA titre level of 128 or above is sufficient to protect broilers against challenge with virulent NDV,( b) Primary vaccination at day 7 followed by a booster dosing at day 28 may be followed for better immune response and protection against ND in broilers.DOI: 10.3329/bjvm.v7i2.5995Bangl. J. Vet. Med. (2009). 7(2) : 296 – 302
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Mosley-Thompson, Ellen, Lonnie G. Thompson, John Paskievitch, and Pieter M. Grootes. "Shallow-Core Analysis and Pit Studies at Siple Station, Antarctica: Implications for Extraction of a 500 Year Proxy Climate Record (Abstract)." Annals of Glaciology 10 (1988): 212. http://dx.doi.org/10.1017/s0260305500004584.
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Two cores, 302 and 132 m long, were drilled 1.5 km up-wind from Siple Station (75°55'S, 84°15'W) during the 1985–86 austral summer. These cores are expected to contain an annually resolvable 500 year record of atmospheric constituents. The entire length of these cores will be analyzed for insoluble particulate concentrations, liquid conductivity, and oxygen-isotope ratios. Anion concentrations (Cl−, SO4 2−) will be measured in selected sections. The extraction of a proxy climate history from these cores requires an assessment of the temporal quality and the spatial variability of the preserved record. This paper presents this assessment, which is based upon an extensive investigation of both pit and shallow-core (20 m) records. To complement the two deeper cores, eight 20 m cores were drilled and three pits were sampled. The pits were excavated up-wind of the drill site at distances between 0.5 and 1.0 km. In the central pit, 2.8 m deep, walls A and C (each 1 m wide) were positioned parallel to the prevailing wind, with wall B (4 m wide) perpendicular to the prevailing wind. The stratigraphy of wall B was mapped and continuous vertical profiles of samples were collected for microparticle concentrations (MPC), oxygen-isotopic ratios (δ18O), anion chemistry (AC) and liquid conductivity (LC). Three 20 m cores, each associated with a vertical profile of pit samples, were drilled 0.5 m behind wall B. In addition, part of one core was sampled for beta radioactivity in order to isolate the 1965–66 horizon which resulted from atmospheric thermonuclear testing. Pits 2 and 3 were both 2 m deep and consisted of two 1 m wide perpendicular walls. Each wall was sampled for MPC, δ18O, LC and AC, and one 20 m core was drilled behind each wall. The visible stratigraphy of both walls in pit 3 was mapped. Densities were measured in each pit. The results from the pit and shallow-core analyses lead to the following conclusions. The high frequency of storm events, often associated with winds in excess of 50 knots, leads to substantial drifting. The result is that stratigraphic features in the uppermost annual layer (e.g. crusts, mass-loss layers, hard layers, etc.) exhibit substantial vertical deviations and, on occasion, are laterally discontinuous. Substantial variation may occur over very short distances: e.g. a 2 cm thick melt feature pinched out over a distance of 10 cm. Interestingly, the stratigraphy in firn older than 1 year exhibits much less lateral variation. In fact, several distinct visible stratigraphic features can be correlated among most of the shallow cores and the two deeper cores. Examples will be presented. These features provide excellent time-stratigraphic markers for cross-core comparisons. Of special interest is the presence of a major melt feature, first reported by Swiss investigators in 1983. This feature, present at four different drill sites, allows time-stratigraphic correlation and yields nearly identical 10 year accumulation rates for all four sites. Such spatial continuity means that accumulation histories reconstructed from the two deeper cores should be representative of this area. The MPC measurements (particles per ml of water) are the lowest that have been measured. No measurements of atmospheric particulate concentrations are available, but the low concentrations probably result from the high annual accumulation (∼0.55 m a−1, water equivalent), which dilutes the atmospheric input signal of particulates preserved in the firn. Swiss investigators reported similar results for the dilution of volcanic acids (e.g. SO4 2−), which muted the conductivity signals in a 201 m Siple Station core. The low concentrations make particles difficult to use for dating Siple cores. On the other hand, the low background levels of particulates may make Siple Station an excellent site for monitoring major atmospheric turbidity events (e.g. prolonged periods of desertification or volcanic activity). The high annual accumulation leads to the excellent preservation of the δ18O annual signal. The annual δ18O signal ranges from 15‰ at the surface to 8‰ at 122 m, so it is probable that the annual δ18O signal will be preserved over the entire 500 year record, allowing nearly absolute dating of the core. The potential of a nearly absolute time-scale, coupled with detailed particulate, liquid-conductivity and δ18O histories, should provide the first proxy climate record from this area. This 500 year history will complement similar records anticipated from the Antarctic Peninsula (∼73° S) and that recently constructed from the James Ross Island ice cap. A more global climatic picture of the last 500 years may be obtained when these high-resolution Antarctic ice-core records are integrated with non-polar records (e.g. the Quelccaya ice cap, Peru, and the Dunde ice cap, China) of similar quality.
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Mosley-Thompson, Ellen, Lonnie G. Thompson, John Paskievitch, and Pieter M. Grootes. "Shallow-Core Analysis and Pit Studies at Siple Station, Antarctica: Implications for Extraction of a 500 Year Proxy Climate Record (Abstract)." Annals of Glaciology 10 (1988): 212. http://dx.doi.org/10.3189/s0260305500004584.
Full textAbstract:
Two cores, 302 and 132 m long, were drilled 1.5 km up-wind from Siple Station (75°55'S, 84°15'W) during the 1985–86 austral summer. These cores are expected to contain an annually resolvable 500 year record of atmospheric constituents. The entire length of these cores will be analyzed for insoluble particulate concentrations, liquid conductivity, and oxygen-isotope ratios. Anion concentrations (Cl−, SO42−) will be measured in selected sections. The extraction of a proxy climate history from these cores requires an assessment of the temporal quality and the spatial variability of the preserved record. This paper presents this assessment, which is based upon an extensive investigation of both pit and shallow-core (20 m) records.To complement the two deeper cores, eight 20 m cores were drilled and three pits were sampled. The pits were excavated up-wind of the drill site at distances between 0.5 and 1.0 km. In the central pit, 2.8 m deep, walls A and C (each 1 m wide) were positioned parallel to the prevailing wind, with wall B (4 m wide) perpendicular to the prevailing wind. The stratigraphy of wall B was mapped and continuous vertical profiles of samples were collected for microparticle concentrations (MPC), oxygen-isotopic ratios (δ18O), anion chemistry (AC) and liquid conductivity (LC). Three 20 m cores, each associated with a vertical profile of pit samples, were drilled 0.5 m behind wall B. In addition, part of one core was sampled for beta radioactivity in order to isolate the 1965–66 horizon which resulted from atmospheric thermonuclear testing. Pits 2 and 3 were both 2 m deep and consisted of two 1 m wide perpendicular walls. Each wall was sampled for MPC, δ18O, LC and AC, and one 20 m core was drilled behind each wall. The visible stratigraphy of both walls in pit 3 was mapped. Densities were measured in each pit. The results from the pit and shallow-core analyses lead to the following conclusions.The high frequency of storm events, often associated with winds in excess of 50 knots, leads to substantial drifting. The result is that stratigraphic features in the uppermost annual layer (e.g. crusts, mass-loss layers, hard layers, etc.) exhibit substantial vertical deviations and, on occasion, are laterally discontinuous. Substantial variation may occur over very short distances: e.g. a 2 cm thick melt feature pinched out over a distance of 10 cm. Interestingly, the stratigraphy in firn older than 1 year exhibits much less lateral variation. In fact, several distinct visible stratigraphic features can be correlated among most of the shallow cores and the two deeper cores. Examples will be presented. These features provide excellent time-stratigraphic markers for cross-core comparisons. Of special interest is the presence of a major melt feature, first reported by Swiss investigators in 1983. This feature, present at four different drill sites, allows time-stratigraphic correlation and yields nearly identical 10 year accumulation rates for all four sites. Such spatial continuity means that accumulation histories reconstructed from the two deeper cores should be representative of this area.The MPC measurements (particles per ml of water) are the lowest that have been measured. No measurements of atmospheric particulate concentrations are available, but the low concentrations probably result from the high annual accumulation (∼0.55 m a−1, water equivalent), which dilutes the atmospheric input signal of particulates preserved in the firn. Swiss investigators reported similar results for the dilution of volcanic acids (e.g. SO42−), which muted the conductivity signals in a 201 m Siple Station core. The low concentrations make particles difficult to use for dating Siple cores. On the other hand, the low background levels of particulates may make Siple Station an excellent site for monitoring major atmospheric turbidity events (e.g. prolonged periods of desertification or volcanic activity).The high annual accumulation leads to the excellent preservation of the δ18O annual signal. The annual δ18O signal ranges from 15‰ at the surface to 8‰ at 122 m, so it is probable that the annual δ18O signal will be preserved over the entire 500 year record, allowing nearly absolute dating of the core.The potential of a nearly absolute time-scale, coupled with detailed particulate, liquid-conductivity and δ18O histories, should provide the first proxy climate record from this area. This 500 year history will complement similar records anticipated from the Antarctic Peninsula (∼73° S) and that recently constructed from the James Ross Island ice cap. A more global climatic picture of the last 500 years may be obtained when these high-resolution Antarctic ice-core records are integrated with non-polar records (e.g. the Quelccaya ice cap, Peru, and the Dunde ice cap, China) of similar quality.
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Miguez, Maria Jose, Diego Bueno, and Caroline Perez. "Disparities in Sleep Health among Adolescents: The Role of Sex, Age, and Migration." Sleep Disorders 2020 (January 28, 2020): 1–6. http://dx.doi.org/10.1155/2020/5316364.
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Background. Disparities in sleep disturbances have been described in adults; nevertheless, among adolescents, data have yielded conflicting results. Therefore, analyses of our cohort study of 500 urban, normally developed Hispanic adolescents (10–18 years), aim to determine if rates of sleep debt differ between: (a) male and female adolescents, (b) US-born Hispanics and first-generation immigrant ethnic counterparts, and (c) specific activities that these teens trade for sleep. Participants’ weekday and weekend sleep patterns, along with the reasons for sleeping less than the recommended hours were recorded. Standardized surveys were used to gather information regarding sociodemographics, migration, acculturation, and medical history. Using the criteria set forth by the National Sleep Foundation, analyses indicated that sleep deprivation is a pervasive problem, with 75% in the preadolescents and 45% of the late adolescents exhibiting sleep problems. Females slept on average at least one hour less per day than their male counterparts (7 vs. 8 hours). The sleep problems were rooted in several overlapping causes, including use of technology, video games, studying, and employment. Nevertheless, reasons for sleep loss differed by gender and by immigrant status. Multivariable adjusted logistic regression analyses showed that females, US-born teens, and preadolescents had higher odds of being sleep deprived. Pediatricians and sleep experts should be aware of gender-specific causes and responses of sleep problems. Cultural ecological frameworks need to be considered, and clearly indicate that findings may not generalize to youth from other cultural backgrounds.
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Baltes, Elizabeth P. "THE POST-CLASSICAL GREEK AGORA - (C.P.) Dickenson On the Agora. The Evolution of a Public Space in Hellenistic and Roman Greece (c. 323 bc – 267 ad). (Mnemosyne Supplements 398.) Pp. xviii + 480, b/w & colour ills, maps. Leiden and Boston: Brill, 2017. Cased, €175, US$194. ISBN: 978-90-04-32671-2." Classical Review 68, no. 1 (December 13, 2017): 208–10. http://dx.doi.org/10.1017/s0009840x17002268.
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Chen, Hongbin, Manuel R. Modiano, Joel W. Neal, Julie R. Brahmer, James R. Rigas, Robert M. Jotte, Natasha B. Leighl, et al. "A phase II multicenter study of aflibercept (AFL) in combination with cisplatin (C) and pemetrexed (P) in patients with previously untreated advanced/metastatic nonsquamous non-small cell lung cancer (NSCLC)." Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): 7541. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.7541.
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7541 Background: AFL is a recombinant human fusion protein that acts as a decoy receptor and prevents the interaction of vascular endothelial growth factor (VEGF)-A, VEGF-B, and placental growth factor with their receptors. This study evaluated the efficacy and safety of AFL in combination with first-line chemotherapy of C and P in NSCLC. Methods: This phase II, single arm, open label, multicenter trial in patients with previously untreated, locally advanced, or metastatic NSCLC excluded patients with squamous histology, cavitating lesions, ECOG > 1, uncontrolled hypertension, or brain/CNS metastases. All patients received IV AFL 6 mg/kg, P 500 mg/m2, and C 75mg/m2, every 3 weeks for up to 6 cycles. For those who completed the combined chemotherapy, Q3W administration of AFL was to continue until disease progression, intolerable toxicity, or any other cause for withdrawal. The primary endpoints were objective response rate (ORR) and progression free survival (PFS). Planned sample size was 72 patients. Results: The study was closed prematurely due to 3 confirmed cases of reversible posterior leukoencephalopathy syndrome (RPLS). A total of 42 patients were enrolled. Median age was 61.5 years; 54.8% were male, 85.7% white and 50% ECOG 0. A median of 4 cycles of AFL was administered. The most common treatment-emergent adverse events (TEAEs) of any grade were nausea (69%) and fatigue (67%), with hypertension (36%) as the most common grade 3/4 TEAE. The 3 patients with RPLS were Caucasian women. Two had a history of hypertension and both experienced elevated BP and reduced CrCl. Of the 38 patients evaluable for response, ORR was 26.3% (95% CI, 12.3-40.3%) and median PFS was 5 months (95% CI, 4.3-7.1). Conclusions: The rate of RPLS observed in this study with AFL + C + P was higher than anticipated. A meta-analysis of safety from three large placebo-controlled studies reported no RPLS among 1333 patient treated with AFL + chemotherapy, and none was reported in prior combination studies of AFL + P or AFL + C + docetaxel. Though the study was stopped early, ORR and PFS were in accordance with most historical first-line NSCLC studies.
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Santo, V. Espirito, A. R. Figueiredo, R. Almendra, A. Almeida, P. Guimaraes, and A. G. Velon. "Think Fast, Treat Faster – A Case of a Treatable Rapidly Progressive Dementia." European Psychiatry 33, S1 (March 2016): S476. http://dx.doi.org/10.1016/j.eurpsy.2016.01.1738.
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IntroductionRapidly progressive dementias (RPD) are conditions that develop over days, weeks or months, which could be treatable if diagnosed in the acute phase.Clinical caseA 62-year-old man with personal history of type 2 diabetes, started complaining of fronto-temporal headache, nausea and sub-febrile temperature. He went to his family doctor who prescribed ciprofloxacin 500 mg bid. Later on, he had difficulty to sleep and referred complex visual hallucinations. His family noted involuntary movements of the left upper limb and that he became more clumsy needing help for daily life activities. He went to our hospital one week later. He was apyretic and hemodynamically stable. On neurological examination, he had executive and visuospecial dysfunction, left limbs bradykinesia and ipsilateral limb ataxia. Involuntary movements of his left upper limb resembled alien limb phenomena. Complete blood count, complete metabolic panel, iron, folic acid, vitamin B12, anti-neuronal antibodies were normal. HIV, hepatitis B and C serologies were negative. Cerebrospinal fluid study showed 4 cells (100% mononuclear), normal glucose and protein levels, negative bacteriological exam but positive Herpes Simplex-1 Virus (HSV) DNA. Brain CT and MRI showed signs of ischemic microangiopathic leukoencephalopathy. He started treatment with acyclovir 30 mg/kg/d IV and quetiapine 100 mg id. His symptoms improved but he remained with a mild mnesic cognitive deficit and bradykinesia that stayed stable 3 years later.ConclusionThis case exemplifies atypical HSV-1 encephalitis, one cause of RPD, that an early recognition is essential to reduce its associated morbidity.Disclosure of interestThe authors have not supplied their declaration of competing interest.
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Louzao Villar, Joseba. "La Virgen y lo sagrado. La cultura aparicionista en la Europa contemporánea." Vínculos de Historia. Revista del Departamento de Historia de la Universidad de Castilla-La Mancha, no. 8 (June 20, 2019): 152. http://dx.doi.org/10.18239/vdh_2019.08.08.
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RESUMENLa historia del cristianismo no se entiende sin el complejo fenómeno mariano. El culto mariano ha afianzado la construcción de identidades colectivas, pero también individuales. La figura de la Virgen María estableció un modelo de conducta desde cada contexto histórico-cultural, remarcando especialmente los ideales de maternidad y virginidad. Dentro del imaginario católico, la Europa contemporánea ha estado marcada por la formación de una cultura aparicionista que se ha generadoa partir de diversas apariciones marianas que han establecido un canon y un marco de interpretación que ha alimentado las guerras culturales entre secularismo y catolicismo.PALABRAS CLAVE: catolicismo, Virgen María, cultura aparicionista, Lourdes, guerras culturales.ABSTRACTThe history of Christianity cannot be understood without the complex Marian phenomenon. Marian devotion has reinforced the construction of collective, but also of individual identities. The figure of the Virgin Mary established a model of conduct through each historical-cultural context, emphasizing in particular the ideals of maternity and virginity. Within the Catholic imaginary, contemporary Europe has been marked by the formation of an apparitionist culture generated by various Marian apparitions that have established a canon and a framework of interpretation that has fuelled the cultural wars between secularism and Catholicism.KEY WORDS: Catholicism, Virgin Mary, apparicionist culture, Lourdes, culture wars. BIBLIOGRAFÍAAlbert Llorca, M., “Les apparitions et leur histoire”, Archives de Sciences Sociales des religions, 116 (2001), pp. 53-66.Albert, J.-P. y Rozenberg G., “Des expériences du surnaturel”, Archives de Sciences Sociales des Religions, 145 (2009), pp. 9-14.Amanat A. y Bernhardsson, M. T. (eds.), Imagining the End. Visions of Apocalypsis from the Ancient Middle East to Modern America, London and New York, I. B. Tauris, 2002.Angelier, F. y Langlois, C. (eds.), La Salette. Apocalypse, pèlerinage et littérature (1846-1996), Actes du colloque de l’institut catholique de Paris (29- 30 de novembre de 1996), Grenoble, Jérôme Million, 2000.Apolito, P., Apparitions of the Madonna at Oliveto Citra. Local Visions and Cosmic Drama, University Park, Penn State University Press, 1998.Apolito, P., Internet y la Virgen. Sobre el visionarismo religioso en la Red, Barcelona, Laertes, 2007.Astell, A. W., “Artful Dogma: The Immaculate Conception and Franz Werfer´s Song of Bernadette”, Christianity and Literature, 62/I (2012), pp. 5-28.Barnay, S., El cielo en la tierra. Las apariciones de la Virgen en la Edad Media, Madrid, Encuentro, 1999.Barreto, J., “Rússia e Fátima”, en C. Moreira Azevedo e L Cristino (dirs.), Enciclopédia de Fátima, Estoril, Princípia, 2007, pp. 500-503.Barreto, J., Religião e Sociedade: dois ensaios, Lisboa, Instituto de Ciências Sociais da Universidade de Lisboa, 2003.Bayly, C. 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Wong Medina, Jorge A. "LANDS AND POPULATIONS IN EARLY GREECE - (M.) Oller, (J.) Pàmias, (C.) Varias (edd.) Tierra, territorio y población en la Grecia Antigua: aspectos institucionales y míticos. In two volumes. Pp. xxii + 244 + viii + 265, b/w & colour ills. Mering: Utopica Verlag, 2017. Cased, €56. ISBN: 978-3-944735-00-9 (vol. 1), 978-3-944735-01-6 (vol. 2)." Classical Review 69, no. 2 (June 28, 2019): 496–99. http://dx.doi.org/10.1017/s0009840x19001070.
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ATHANASSOPOULOU (Φ. ΑΘΑΝΑΣΟΠΟΥΛΟΥ), F. "The history of development of medicine through time: a repeated case." Journal of the Hellenic Veterinary Medical Society 60, no. 2 (November 20, 2017): 125. http://dx.doi.org/10.12681/jhvms.14921.
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At all times, man was interested in the therapy of diseases in any possible way. In the Hellenic world, that is generally regarded as the spiritual predecessor of recent Europe, two distinct traditions existed: the first had a true sacred origin and was practiced from a corporation or guild of healers/priests named zsAsklipiades. Asklipios, son of Apollo, was considered by them as their generic leader. The second, practiced by Vakhes, comes from indigenous populations of Eastern Aegean area approx. at 2000 B.C. During its practice patients went into a sacred mania ie., with dancing, music, or body exertion went into an extended consciousness from which, when they recovered, they showed a peaceful state and a new identity again due to moral comprehension. The first liberation from sacred ceremonies occurs in ancient Greece from Hippocrates and thus the first step towards scientific medicine occurs and it is practiced by cosmic healers. To Hippokrates we owe the meaning of "method" for the observation and development of the disease and its symptoms (there is a distinction between them). He believed in "the self healing capability of nature" that had to be taken into account, because medicine comes from the disruption of the balance between man and environment. After Hippocrates there is a gap of approx. 7 eons (till 3rd century D.C.) during which period important developments occur that will determine later the path of medicine: 1. During the 1st century B.C., Dioscouridis from Alexandria and in the 2ndcentury D.C. Asklipiadis and the great healer and surgeon from Pergamos, Galinos, transplanted the "absolute medical orthodoxy" in Rome where it remained as a dogma until the 16th century D.C. This is similar to Arab and recent European medicine. Hippocrates and Galinos beliefs have a lot in common with the growth of medicine in China and India. 2.Arab philosophers and healers reconnect medicine with politics and their base is the healthy society. 3. In Christianity, in the Middle Ages, the human body is discarded as not * worthy and surgery and anatomy are prohibited. In 1130 D.C. the practice of medicine by monks isprohibited and this is passed on to "cosmic clergy" from where the first schools of medicine and recent Universities originate (Paris, Oxford, Bologna, Montpellier). With Renaissance starts the questioning of the Galino's theory. The main archetype of the healer of this period was undoubtedly Paracelsus. He brings back the correlations of symptoms and moral attitude and his whole comprehension was "ecosystematic" and "psychosomatic". The healing ideas and practices of the Middle Ages and Eastern world are various and come from different origins without being an identical philosophical model, but they have the following similar points changed eventually by the "scientific medicine" born after the Cartesian debate: a) there is a bond between body and psyche, b) there is a bond of interaction between the human body and the environment, c) there is a mutual bond of equality and trust between the patient and the healer. The important developments between the 17th - 18th centuries (discovery of the microscope, growth of laboratories and clinics) will give a tremendous push to this scientific medicine and will allow to discard the patient as a whole person for the favour of the diagnosis and the manipulation of "diseases and syndromes". Another disruption from this course of scientific medicine occurs with the emergence of biology as a distinct science, which brought the uprising of the usual vitalistic beliefs that during in the 18th century did not totally stop to exist (G. Stahl-anima, S. Hahneman- homeopathy). However, due to the positivistic direction that the great physiologist of the 19th century, C. Bernard (who established in medicine the quantification according to the prototype of positive Sciences) and finally L. Pasteur established with the discovery of the bacterial role, strengthened again the self confidence of the classical/ scientific medicine. In 20th century, medicine gains also powers and is connected socially also with the growing pharmaceutical, but still is unable to heal satisfactory the mental / psychological illnesses; meantime, the recent specialization opened up a new horizon of medical applications (molecular biology, neurochemistry, clear understanding of the immunological-nervous-endocrinological mechanism) that are, however, part of the same mechanical model. The malpractice of this model involved attachment of medicine and politics in a programme that experimentally was performed in the Nazis camps. Again, three subsequent currents of developments questioned the medical orthodox theory during most of 20th century: S. Freud and psychoanalysis, the phenomenological medicine of E. Husserl and modern alternative medicines (homeopathy, acupuncture).
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Kubasch, Anne Sophie, Aristoteles Giagounidis, Georgia Metzgeroth, Anna Jonasova, Regina Herbst, Jose Miguel Torregrosa Diaz, Benoit De Renzis, et al. "A Molecular-Based Response Prediction Model to Romiplostim in Patients with Lower-Risk Myelodysplastic Syndrome and Severe Thrombocytopenia." Blood 136, Supplement 1 (November 5, 2020): 44–45. http://dx.doi.org/10.1182/blood-2020-139291.
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*UP, LA contributed equally Introduction A significant proportion of lower risk (LR)-MDS patients present with thrombocytopenia, being associated with shortened survival and higher risk of progression to acute myeloid leukemia (AML). Treatment options for patients with LR-MDS and severe thrombocytopenia remain limited apart from transfusion support. Romiplostim (ROM), a thrombopoietin receptor agonist (TPO-RA) has shown safety and efficacy dependent on endogenous TPO levels as well as platelet transfusion history in a poorly defined subset of LR-MDS patients (Giagounidis et al. Cancer 2014, Sekeres et al. BJH 2014). Methods The multicenter phase 2 EUROPE trial investigated potential biomarkers of response (e.g. TPO levels, molecular markers) to single agent ROM in LR-MDS patients with severe thrombocytopenia. Patients were eligible if platelet counts were ≤30 G/L or ≤50 G/L in case of bleeding history. The primary efficacy endpoint was the rate of hematologic improvement of platelets (HI-P, according to IWG 2006 criteria) lasting for at least 8 weeks after 16 weeks of ROM (750µg SC qw) treatment. At the time of screening, patients were assigned into 3 different cohorts based on their previous platelet transfusion events (PTE) as well as centrally assessed TPO serum levels (A: TPO<500 ng/l, PTE<6 units/past year; B: TPO<500 ng/l, PTE≥6 units or TPO≥500 ng/l, PTE<6 units, C: TPO≥ 500 ng/l, PTE≥6 units). Bone marrows analysis were centrally reviewed. Results From 2015 to 2019, a total of 79 patients were included at 29 trial sites in Germany, France and the Czech Republic. Patients' median age was 74 years (range 42-93), median baseline platelet count was 25.5 G/L (range 3-50 G/L) and they were stratified into cohort A (n=51) or B+C (n=28), respectively. The primary endpoint was met with 34 out of 79 (43%) patients responding (HI-P), with response being markedly higher in cohort A (49%, n=25) vs. cohort B and C (32%, n=9) (p=0.145). Ten (13%) and eight (10%) patients had additional neutrophil (HI-N) and erythroid (HI-E) responses, respectively. During treatment, six patients had transient increases in peripheral blasts to more than 10% and one patient progressed to AML after one month of ROM. Although a higher number of responders was observed in group A, neither TPO level at screening (p=0.21), nor number of pretreatment PTE (p=0.12) were significantly associated with response to ROM treatment. Thus, our findings do not confirm that baseline TPO levels and number of pretreatment PTE alone allow reliable prediction of response to ROM. With the aim to identify new molecular patterns correlating with response, we performed a targeted NGS analysis for somatic variants in 54 candidate genes in 75 patients at baseline and in 44 patients after 16 weeks of ROM. Responders (R) more frequently exhibited mutations like SRSF2 (R=39%, NR=17%), RUNX1 (R=24%, NR=14%) and TET2 (R=30%, NR=29%), whereas non-responders (NR) exhibited mutations like DNMT3A (R=12%, NR=21%), U2AF1(R=9%, NR=14%) or ASXL1 (R=6%, NR 17%) more frequent. The percentages of patients with a response to ROM were similar regardless of total number of baseline somatic mutations. Comparing responders vs. non-responders, we found no significant changes of variant allelic burden of variants detected pre- and post-ROM (Fig. 1). We identified the presence of a SRSF2 mutation as a significant predictor of response to ROM treatment (p=0.031, logistic regression). Mutated SRSF2 was significantly more frequent in responders (39%) compared to non-responders (17%) (p=0.036, Fisher's exact test) (Fig. 2A,B). We used logistic regression with stepwise backward selection to assess the influence of the presence of ASXL1, DNMT3A, RUNX1, TET2 and SRSF2 mutations on response. Our final regression model excludes the non-significant ASXL1, DNMT3A, RUNX1 and TET2 mutations and includes the significant SRSF2 mutation, resulting in an overall accuracy of 64.0% for a correct ROM response prediction in this patient cohort. Conclusion: This prospective study did not confirm a significant association between response to ROM, pretreatment PTE burden and endogenous TPO levels. Instead, patients with a mutated SRSF2 displayed a significantly higher response to ROM treatment. This may allow personalized treatment approaches in patients with LR-MDS and severe thrombocytopenia. In this study, extended treatment with ROM did not lead to a significant increase in AML cases. Disclosures Kubasch: Shire: Research Funding; Celgene: Research Funding; Novartis: Research Funding. Giagounidis:AMGEN: Membership on an entity's Board of Directors or advisory committees; Novartis: Membership on an entity's Board of Directors or advisory committees. Götze:Celgene: Research Funding. Cony-Makhoul:Novartis: Consultancy; Pfizer: Consultancy; Incyte Biosciences: Speakers Bureau; BMS: Consultancy; BMS: Speakers Bureau. Laribi:takeda: Research Funding; novartis: Honoraria, Research Funding; amgen: Research Funding; abbvie: Honoraria, Research Funding. Park:Takeda: Membership on an entity's Board of Directors or advisory committees, Research Funding; Novartis: Membership on an entity's Board of Directors or advisory committees; Celgene: Membership on an entity's Board of Directors or advisory committees, Research Funding; Pfizer: Other: Travel expenses. Metzeler:Astellas: Honoraria; Otsuka Pharma: Consultancy; Pfizer: Consultancy; Jazz Pharmaceuticals: Consultancy; Novartis: Consultancy; Celgene: Consultancy, Honoraria, Research Funding; Daiichi Sankyo: Honoraria. Thiede:AgenDix GmbH: Other: Co-owner and CEO. Schlenk:PharmaMar: Research Funding; Daiichi Sankyo: Membership on an entity's Board of Directors or advisory committees, Other: Travel, Accomodations, Expenses, Research Funding, Speakers Bureau; Novartis: Speakers Bureau; Roche: Research Funding; AstraZeneca: Research Funding; Pfizer: Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau. Fenaux:Novartis: Honoraria, Research Funding; Abbvie: Honoraria, Research Funding; Jazz: Honoraria, Research Funding; BMS: Honoraria, Research Funding. Platzbecker:Novartis: Consultancy, Honoraria, Research Funding; Amgen: Honoraria, Research Funding; BMS: Consultancy, Honoraria; AbbVie: Consultancy, Honoraria; Geron: Consultancy, Honoraria; Takeda: Consultancy, Honoraria; Janssen: Consultancy, Honoraria, Research Funding. Ades:Abbvie: Honoraria, Membership on an entity's Board of Directors or advisory committees; Amgen: Research Funding; takeda: Honoraria, Membership on an entity's Board of Directors or advisory committees; novartis: Research Funding; Celgene/BMS: Research Funding; jazz: Membership on an entity's Board of Directors or advisory committees, Research Funding. OffLabel Disclosure: Romiplostim is a thrombopoietin receptor agonist indicated for the treatment of thrombocytopenia in patients with chronic immune thrombocytopenia (ITP). Limitations of Use: Romiplostim is not indicated for the treatment of thrombocytopenia due to myelodysplastic syndrome (MDS) or any cause of thrombocytopenia other than chronic ITP.
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Khasru, Moshiur Rahman, Md Abu Bakar Siddiq, Kazi Mohammad Sayeeduzzaman, Tangila Marzen, and Abul Khair Mohammad Salek. "Coexistence of Rheumatoid Arthritis, Systemic Lupus Erythematosus, Sjogren Syndrome, Antiphospholipid Syndrome, and Ankylosing Spondylitis." Case Reports in Rheumatology 2021 (August 10, 2021): 1–5. http://dx.doi.org/10.1155/2021/8491717.
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A 37-year-old Bangladeshi woman presented with low back and several joints pain and swelling for months together; there was significant morning stiffness for more than two hours. Repeated abortions, dry eye, hair fall, photosensitivity, and oral ulcer were the additional complaints. Clinical examination unveiled asymmetrical peripheral and both sacroiliac joint tenderness, positive modified Schober’s test, and limited chest expansion. Schirmer’s test was positive. The history of rheumatoid arthritis (RA) and ankylosing spondylitis (AS) among 1st-degree relatives was also significant. Biochemical analysis revealed pancytopenia, raised erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), and mild microscopic proteinuria. The patient was seropositive for rheumatoid factor (RF), antibodies against cyclic citrullinated peptides (anti-CCP), antinuclear antibody (ANA), anti-Sm antibody, anti-Sjögren’s-syndrome-related antigen A and B (anti-SSA/SSB), antiphospholipid (aPL-IgG/IgM), and HLA B27; however, serum complement (C3 and C4) levels were normal. Basal cortisol level measured elevated. Besides, X-ray and MRI of lumbosacral spines demonstrated sacroiliitis. There was radiological cardiomegaly, echocardiography unveiled atrial regurgitation, and ascending aorta aneurysm. Based on the abovementioned information, RA, AS, and systemic lupus erythematosus (SLE) have been diagnosed. Moreover, the patient developed Sjogren’s syndrome (SS), antiphospholipid lipid syndrome (APS), Cushing syndrome, ascending aorta aneurysm, and atrial regurgitation. Her disease activity score for RA (DAS28), DAS for AS (ASDAS), SLE disease activity index (SLEDAI), and Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) scores were 3.46, 2.36, 23, and 5, respectively. The patient received hydroxychloroquine (200 mg daily), pulsed cyclophosphamide, prednisolone (20 mg in the morning), and naproxen 500 mg (twice daily). To our best knowledge, this is the first report documenting RA, AS, and SLE with secondary SS and APS.
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Zakai, Neil, Peter Callas, Allen Repp, and Mary Cushman. "Development and Testing of a Risk Assessment Model for Venous Thrombosis in Medical Inpatients: the Medical Inpatients and Thrombosis (MITH) Study Score." Blood 118, no. 21 (November 18, 2011): 173. http://dx.doi.org/10.1182/blood.v118.21.173.173.
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Abstract Abstract 173FN2 Introduction: Multiple government organizations (i.e. the Joint Commission in the United States and the National Institute for Health and Clinical Excellence in the United Kingdom) mandate venous thrombosis (VT) risk assessment for hospitalized patients and provision of VT prophylaxis, however there are no validated VT risk assessment models (RAM) available for use in medical inpatients. Methods: Between January 2002 and June 2009 all cases of VT complicating medical admissions were identified using ICD-9 codes and confirmed by medical record review at a 500 bed teaching hospital. Two controls without VT were frequency matched to each case by admission service (medicine, cardiology, and oncology) and admission year. VT required positive imaging or autopsy. Medical history, presenting conditions, and use of VT prophylaxis in cases and controls were assessed by chart review. Weighted logistic regression was used to calculate odds ratios (OR) and the Taylor series method for 95% confidence intervals (CI) accounting for VT prophylaxis use (both mechanical and pharmacologic). A RAM was developed using clinical judgment and sequentially adding risk factors into a multivariable model. A point value was assigned for each risk factor by dividing the b coefficients' by the lowest b coefficient value and rounding to the nearest integer. To validate the model, the 95% CI for the C-statistic was calculated using bootstrapping with 1000 replicate samples. Results: 299 cases of VT and 601 matched controls were reviewed. The rate of VT per 1000 admissions (95% CI) was 4.6 (3.9, 5.4). Table 1 presents the RAM with the point value for each risk factor. The c-statistic for the model was 0.73 (95% CI 0.70, 0.76). Using a cut-off of ≥2 points as high risk, 79% of cases and 39% of controls were classified as high risk. The probability of VT in the absence of VT prophylaxis for a score <2 was 1.5 (95% CI 1.0, 2.3) per 1000 admissions and for a score ≥2 was 8.8 (95% CI 4.1, 18.8) per 1000 admissions. To evaluate a score assessed by clinical characteristics only, we assessed a score with the same risk factors but removing platelet count and white cell count from the model. The C-statistic was 0.71 (95% CI 0.68, 0.74) and 74% of cases and 39% of controls were high risk. Stratification by admission service or admission to an intensive care unit did not affect interpretation of the results. Conclusion: We present an internally validated RAM that assesses the risk of VT complicating medical admission. The score is simple, relies only on information easily known at the time of admission, and could be incorporated into an electronic medical record. It will allow clinicians to assess VT risk at admission for medical inpatients and weigh the risks and benefits of pharmacologic VT prophylaxis. The RAM will enable further studies to determine optimal VT prevention strategies in medical inpatients. Disclosures: No relevant conflicts of interest to declare.