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Roth, Adam David. "Reciprocal influences between rhetoric and medicine in ancient Greece." Diss., University of Iowa, 2008. http://ir.uiowa.edu/etd/3.
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Barnes, Madeline. "Rational and Temple Medicine in Ancient Greece: The Public Perception of the Two Forms." Scholarship @ Claremont, 2014. http://scholarship.claremont.edu/scripps_theses/442.
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The thesis examines two of the most prominent forms of Ancient Greek medicine, rational and temple. These two forms put themselves in direct competition with each other and often tried to differentiate their form from the other. On the other hand the public often conflated these two types viewing them as one entity instead of two. The perception of Ancient Greeks was that the two forms were actually very similar and the temple practitioners and rational physicians were in many ways interchangeable.
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Morgan-Forster, Antonia H. "Climate, Environment and Malaria during the Prehistory of Mainland Greece." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/1579/.
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Interpretations of osteological remains from mainland Greece during the 1960-1980s led to the suggestion that the most virulent form of malaria, Plasmodium falciparum, was prevalent between the Mesolithic and Late Bronze Age (c. 8700 cal. BC-1100 cal. BC). Although disregarded over the past decade, the theory has regained support in recent years from osteological, epidemiological, environmental and DNA studies. However, the presence of this strain of malaria in prehistoric Greece remains controversial. This thesis evaluates 1) the palaeoclimatic conditions of the Aegean between the Mesolithic and Late Bronze Age and 2) the palaeoenvironmental conditions of three archaeological settlements, with the aim of ascertaining whether the climatic and environmental conditions were as conducive for P. falciparum and the mosquito vectors as the osteological evidence suggested. Equal consideration is given to the so-called ‘lesser strains’ of malaria, P. vivax and P. malariae, the significance of which is considered to have been underestimated in previous studies.
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Jones, Lewis Molly Ayn. "A Dangerous Art: Greek Physicians and Medical Risk in Imperial Rome." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1242865685.
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Lindholm, Hanna. "Treating PTSD among unaccompanied minor refugees in Greece with KidNET : A narrative literature review." Thesis, Uppsala universitet, Teologiska institutionen, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-448931.
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Over the last couple of years, more than a million unaccompanied minor refugees (UMRs) have made it to the European Union. Their journeys have been long, tough, and hard and each unaccompanied minor refugee has a unique story, but they all share one thing. The traumatic events they have witnessed and experienced along the way have affected their mental health. Mental health issues, often symptoms of post-traumatic stress disorder (PTSD) are very common among UMRs. Untreated issues can lead to chronic PTSD, which could impact them for the rest of their lives. UMRs need support to process the traumas they have experienced, and one possible intervention is NET, Narrative Exposure Therapy. NET is an evidence-based, short-term, individual form of therapy. Supported by a therapist, the individual talk through his/her whole life while putting emphasis on the traumatic events aiming to work through and past them. The adapted form of NET that is used to treat children is called KidNET. Based on the hypothesis that KidNET has positive effects, reduces symptoms of PTSD, and strengthens mental health, the aim of the study is to show the effects of KidNET when treating traumatized children diagnosed with PTSD. Further objectives are set to see how effective KidNET is when compared to control groups, and if KidNET can be recommended as a suitable intervention to use among UMRs suffering from PTSD in Greece. A narrative literature review is chosen as the research method to reach the aim. The review revealed overall positive effects when using KidNET as an intervention targeting traumatized children with PTSD in various settings in different parts of the world. Positive effects found were better daily functioning, an ability to engage in meaningful activities, a reduction in feelings of guilt, stigmatization, and suicidal ideation, a decrease in the severity of PTSD and depression symptoms, and a full recovery from major clinical depression and PTSD. No negative effects were found in any of the studies included in the review. Several studies were limited by small sample sizes, no passive control group and not enough follow-up assessments. However, the overall outcome shows successful results and KidNET is found to be a suitable intervention when treating PTSD among UMRs in Greece, but further studies are recommended.On Zoom
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Massar, Natacha. "Soigner et servir: histoire sociale et culturelle de la médecine grecque à l'époque hellénistique." Doctoral thesis, Universite Libre de Bruxelles, 2001. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/211522.
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Cano, Cuenca Jorge. "Politics, diet and health in the Seventh Letter’s medical análogon”." Pontificia Universidad Católica del Perú - Departamento de Humanidades, 2014. http://repositorio.pucp.edu.pe/index/handle/123456789/113019.
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This article pretends to provide a reading of the Seventh Letter focused on the role that medical terminology plays in it. Leaving aside the unsolvable enigma of Plato’s authorship, the letter shows evident connections with fundamental topics from the last” Plato, particularly in its political aspects. In many passages of the Seventh Letter, the figure of the philosopher as an educator appears covered with medical aspects, and the political situation is defined as a pathology that we must treat according to a therapeutic methodology.En este artículo se pretende aportar una lectura de la Carta VII desde la función que desempeña en ella el léxico médico. Dejando al margen la irresoluble cuestión sobre la autoría platónica, la carta muestra conexiones evidentes con temas fundamentales en el llamado último” Platón, principalmente en sus aspectos políticos. En varios pasajes de la Carta VII, la figura del filósofo en tanto educador aparece revestida de aspectos médicos, y la propia situación política es definida como una patología sobre la que hay que actuar de acuerdo con una metodología terapéutica.
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Slaughter, Megan Michelle. "The Hippocratic Corpus and Soranus of Ephesus: Discovering Men's Minds Through Women's Bodies." Scholar Commons, 2011. http://scholarcommons.usf.edu/etd/3351.
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This thesis addresses what cultural influences and social circumstances shaped the works of the Hippocratic Corpus and Soranus's Gynecology. This thesis will illustrate how these medical texts are representative of how women were viewed by men in Classical Greece and Early Imperial Rome, respectively. It deals additionally with how these gynecological works in turn impacted the way in which society viewed and treated women. In particular, these medical writers' changing views of the act of conception shed light on the differing attitudes of their cultures. Thus far research on these time periods and works has focused too narrowly on one aspect of society to do them justice, nor has there been an effort to separate Soranus's work from the Hippocratic Corpus as representative of a completely different culture and time period. Scholarship has not before discussed the importance of who controls power over conception, men or women, as the key to understanding why women were treated they way they were by men.
Using a feminist approach, this thesis examines the culture, mythology, literature, history, and medicine of these cultures, employing cultural morphology to understand how and why they changed. Greek men feared the women in their lives because they believed that women controlled conception. Roman men did not fear the women in their lives but respected them as mothers, for the important reason that women did not control or contribute to conception. All of the cultural evidence examined inclines one to believe that the way women were treated and viewed by men in the Classical period of Greece and the early Imperial period in Rome, is related directly to who held the power over conception of children, men or women.
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Ozarowska, Lidia. "Healing sanctuaries : between science and religion." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:b0cdbe4c-7d43-43a5-ab5f-a108707028f8.
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Divine healing has been often seen in opposition to human healing. The two spheres, have been considered as separate, both in space and in terms of elements involved. Asclepian sanctuaries have been mostly presented as domains of exclusively divine intervention, without any involvement of the human factor, possibly with the sole exception of dream interpretation. However, the written testimonies of temple cures, both those in the form of cure inscriptions dedicated in sanctuaries and the literary accounts of the incubation experience, give us reasons to suppose that the practical side of the functioning of the asklepieia could have assumed the involvement of human medicine, with the extent of this involvement differing in various epochs. Regardless of physicians' participation or its lack in the procedure, the methods applied in sanctuary healing appear to have evolved in parallel to the developments in medicine and their popular perception. Archaeological finds as well as the image of Asclepius as the god of medicine itself seem to confirm this. Nevertheless, by no means should these connections between the two spheres be treated as transforming the space of religious meaning into hospitals functioning under the auspices of a powerful god. Although acknowledging them does entail inclusion of human medicine within the space dedicated to Asclepius, it does not thereby deny the procedure of incubation its religious and metaphysical dimension. On the contrary, it shows that to the Greek mind divine and human healing were not mutually exclusive, but overlapped and coincided with each other, proving that the Greek sense of rationality was quite different from the modern and could comprise far more than what we call today "scientific thinking".
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Ferracci, Elsa. "Edition critique, traduction et commentaire du traité hippocratique des Prénotions de Cos." Thesis, Paris 4, 2009. http://www.theses.fr/2009PA040266.
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Les Prénotions de Cos sont l’un des traités du Corpus hippocratique. L’ouvrage, anonyme, qu’on peut dater des environs du dernier tiers du IVe siècle av. J.-C., se présente comme la réunion de 640 propositions, le plus souvent de style aphoristique, reprises pour plus de la moitié à des traités hippocratiques comme les Aphorismes, le Pronostic, le Prorrhétique I, les Epidémies, le groupe des Maladies I-II-III, ou encore Plaies de la tête. Le contenu de la compilation est exclusivement orienté vers le pronostic médical. Le traité n’a connu qu’une postérité limitée dans l’Antiquité, et n’a été transmis ni en syriaque, ni en arabe ; aucune traduction latine n’est connue avant celle de Calvus, en 1525, qui inaugure le retour des érudits vers les manuscrits transmettant le texte. L’introduction donne une présentation de l’ouvrage (titre, datation, lectorat supposé, rapports avec les autres œuvres du Corpus hippocratique, structure et procédés de composition, théories médicales exposées, style, histoire du traité, traditions directe et indirecte, éditions, dialecte). L’étude s’attache à mettre en évidence la fonction didactique du traité, fonction qui explique tant l’organisation générale que certaines spécificités formelles du texte. L’édition opère un retour systématique vers le manuscrit le plus ancien et le plus conservateur, le Parisinus graecus 2253 (A), et s’appuie également sur la tradition indirecte (traités hippocratiques qui constituent les sources du traité, et commentaires de Galien principalement). Le texte critique, présenté avec les Testimonia, est accompagné d’une traduction, d’un commentaire philologique, historique et médical, et d’annexesThe Coan Prognoses are one of the treatises of the Hippocratic Corpus. The work is anonymous and can be dated from about the last third of the IVth century b.C. It is presented in the form of a collection of 640 propositions, most often written in a aphoristic style, that are for more than half of them taken from Hippocratic treatises like Aphorisms, Pronostic, Prorrhetic I, Epidemics, Diseases I-II-III, or On head wounds. The content of the compilation is exclusively devoted to the medical prognosis. The treatise had only a very limited tradition in the Antiquity, and was translated neither in Syriac nor in Arabic. Any latin translation is known before the Calvus translation (1525), which represents the starting point of the scholars return to the manuscripts which pass down the text. The introduction presents the work (title, datation, readership, relationships with the others Hippocratic treatises, structure and devices of composition, medical theories, style, history of the treatise, direct and indirect traditions, editions, dialect). The edition itself is mainly based on the more ancient and conservative manuscript, the Parisinus graecus 2253 (A), and also on the indirect tradition (Hippocratic treatises which represent the sources of the work, and Galenic commentaries). The Greek text, presented with the Testimonia, is accompanied by a French translation, by a philological, historical and medical commentary, and by appendix
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Fesi, Andrea. "L'espace culinaire grec. Entre Grèce et Grande-Grèce." Thesis, Paris 4, 2017. http://www.theses.fr/2017PA040227.
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Si le regard scientifique porté sur le thème de l’alimentation antique s’est matérialisé au cours des dernières décennies, il s’est pourtant détaché peu d’investigations où l’on a exploité réellement l’espace que l’aliment en lui-même détenait dans la civilisation grecque. Pour tenter de résoudre cette problématique, nous avons fait le choix de porter notre réflexion en se basant sur la comparaison de différentes sources documentaires qui nous ont permis de réaliser un catalogue des aliments les plus consommés en mettant en exergue plusieurs phases ou modes culinaires. Nous nous sommes interrogés également au sujet de certaines pratiques alimentaires et sur le rôle des cuisiniers dans ces démarches en réalisant une énumération de ces individus transmis par les sources, et en dégageant l’existence en Grèce et en Grande-Grèce de plusieurs écoles et de spécialités qu’elles enseignaient. Ce mouvement a porté à la création d’une littérature à sujet gastronomique naufragée dont on conserve pourtant le souvenir dans l’oeuvre encyclopédique d’Athénée de Naucratis. L’alimentation n’avait pas dans l’Antiquité un intérêt éminemment gastronomique mais elle s’est assignée dans les pratiques médicales dès la naissance de cette discipline comme le procédé usité afin de soigner différentes pathologies. Si les recettes au cœur de ce travail participent à distinguer les multiples usages, elles ne permettent pas d’avoir une vision globale des pratiques culinaires au sein de toutes les différents échelles de la société de Grèce et de Grande- Grèce. Maints aspects de ces traditions culinaires restent néanmoins encore d’actualité : il a été constaté, à travers une enquête sur les différents contextes géographiques mis en examen, que certaines recettes ou usages alimentaires dans le cadre culturel ou religieux du monde grec ont pu survivre au fil du tempsScientific works on antique food have been tackled for decades. However, there are few researches that deeply treated the place that the food in itself occupied during the Greek civilization. In order to answer that question, we have decided to focus on different documentary sources by comparing them. These sources enabled us to have a typology of the most eaten food by highlighting many phases or culinary mode. We also asked ourselves about culinary methods and the place of the cook by achieving a list of the different people that appeared in the different sources. To be able to do this, we give emphasis to the existence of different schools and specialties taught in Greece and Great Greece. This movement gave way to the creation of a gastronomic literature that was forgotten and yet it could be found in the encyclopedic work of Athénée of Naucratis. During Antiquity, food did not have a gastronomic purpose. Nevertheless, it was used for medical purposes in order to cure different diseases. The different recipes that are the core of this work help us to distinguish the different use of food. However, they prevent us from having a global view on culinary methods on the different scales that constitute Greece and Great Greece’s society. Yet some aspects of this culinary tradition are still carried on. Indeed, it has been noticed in some geographical areas that some recipes or food use used in the religious or cultural context were able to survive
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Mesnil, Charlie. "La logistique des armées hellénistiques." Thesis, Lille 3, 2017. http://www.theses.fr/2017LIL30035.
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L’usage du terme « logistique » dans son sens militaire est relativement récent dans l’historiographie de la guerre (il date essentiellement de quelques dizaines d’années) et le mot est complexe à définir. S’intéresser à la logistique militaire, c’est non seulement s’intéresser au ravitaillement de l’armée, mais aussi à ses déplacements, son équipement, son logement et son service sanitaire. Des sujets qui sont donc à la fois variés et très différents les uns des autres et pour lesquels les sources ne sont pas toujours satisfaisantes. Le monde hellénistique que nous étudions s’étend de Marseille à Aï Khanoum (Afghanistan) et comprend à la fois les royaumes et les cités. Les espaces concernés influencèrent les choix stratégiques des généraux. L’impact qu’eut la logistique militaire dans l’issue des conflits militaires hellénistiques est difficile à évaluer et peut aller de négligeable à déterminant. Mais la logistique militaire ne se résume pas à l’influence de celles-ci dans les guerres et aborde aussi des questions économiques et socialesThe use of the term "logistics" in its military sense is relatively recent in the historiography of war (it dates essentially from a few decades) and the word is complex to define. To be interested in military logistics isn’t only to be interested in supplying the army, but also in its transport, equipment, housing and sanitary services. These subjects are therefore at the same time varied and very different from each other and the sources aren’t always sufficient. The Hellenistic world we are studying extends from Marseille to Ai Khanoum (Afghanistan) and includes both kingdoms and cities. The spaces concerned influenced the strategic choices of the generals. The impact of military logistics on the outcome of Hellenistic military conflicts is difficult to evaluate and can range from negligible to decisive. Military logistics, however, aren’t limited to their influence in wars, but also concern economic and social issues
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Booth, Sarah. "Indigenous green vegetables used as food and medicine by the K'ekchi people of Alta Verapaz, Guatemala." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=70277.
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The dietary and medicinal uses of indigenous green vegetables were studied quantitatively over a 13-month period in a rural, semi-rural and urban K'ekchi population in Guatemala. Seventeen species of indigenous greens were consumed, with seasonal variation in intake (p $<$.001) being related to agricultural practices. There was a lower frequency of consumption of greens among the urban group (p $<$.001). Within, and between, the communities, individuals exhibited heterogeneity in dietary intake and approaches to treatment of helminthic infection. There was no association between dietary intake of indigenous greens and the socioeconomic indicators measured (age, type of employment, household size and land use score). Proximate composition, calcium, phosphorus, iron, potassium, magnesium, phylloquinone and total carotenes were determined for 13 species of indigenous greens. Composition of 5 of these has not been previously reported. Plasma phylloquinone was tested as a biochemical marker for validating determination of green plant intake.
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Fitzpatrick, R. Coeli. "Galen's necessary causes in Medieval Arabic sources /." Online version via UMI:, 2002.
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Brand, Nadine. "The concept of the sanus homo in the De medicina of Celsus /." Thesis, Link to online version, 2007. http://hdl.handle.net/10019/343.
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Abou-Aly, Amal Mohamed Abdullah. "The medical writings of Rufus of Ephesus." Thesis, Online version, 1992. http://ethos.bl.uk/OrderDetails.do?did=1&uin=uk.bl.ethos.246073.
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BOCCHI, GIUSEPPE. "PHILOSOPHIA MEDICA E MEDICINA RHETORICA IN SENECA." Doctoral thesis, Università Cattolica del Sacro Cuore, 2009. http://hdl.handle.net/10280/526.
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E' possibile approfondire la conoscenza del pensiero senecano tenendo conto delle conoscenze mediche del filosofo. L'influenza della scuola medica Pneumatica, di ispirazione stoica, consente di dimostrare che le passioni come l'ira non sono per Seneca solo malattie dell'anima, ma sindromi psicofisiche che coinvolgono tutti i livelli dell'individuo, alla luce di un monismo corpo- anima possibile solo alla luce delle dottrine Pneuamtiche. Malattie come la mania e la melancolia, inoltre, hanno un decorso particolare che oltre ad influenzare la visione senecana dell'ira, permette anche di comprendere il carattere apparentemente incoerente di alcuni personaggi delle tragedie (Clitennestra, Atreo, Fedra e Medea), che possono essere considerati traduzioni drammaturgiche di sindromi maniaco- depressive.It's possible to deepen our knowledge of Senecan thought by considering his medical knowledge. The influence of the Pneumatic school, inspired by Stoic philosophy, makes possible to show that passions like anger are for Seneca not only soul diseases, but also a kind of psycho- physical syndrome that concerns every aspect of the individual in the light of a psycho- physical monism that is possible to understand only through the Pneumatic doctrines. Diseases like mania and melancholy, moreover, have a peculiar development which, influencing Senecan view of anger, let us understand the apparently incoherent features of some characters of the tragedies (Clitaemestra, Atreus, Phaedra, Medea) who can be considered dramatic translations of manic- depressive syndromes
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Taylor, Stephanie C. "The bare necessities? : a comparative study of the material evidence for Roman medical practice in urban domestic and army spheres /." St Andrews, 2007. http://hdl.handle.net/10023/400.
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Barlagiannis, Athanasios. "Hygiène publique et construction de l'Etat grec, 1833-1845 : la police sanitaire et l'ordre public de la santé." Thesis, Paris, EHESS, 2017. http://www.theses.fr/2017EHES0044.
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Ce travail porte sur le développement de l’hygiène publique dans le royaume de Grèce entre 1833, année de l’accession au trône du prince Othon de Bavière, et 1845, lorsqu’un système complet des lazarets et d’offices de santé trace les frontières politiques et épidémiologiques du royaume. Après avoir traité les structures de prévention sanitaire érigées tantôt à l’intérieur du pays (vaccinateurs, médecins publics, médecins municipaux) tantôt sur ses frontières, nous étudions les mesures pour lutter contre les maladies contagieuses (surtout la peste et la variole) et contre les miasmes. Nous nous efforçons d’analyser également les maladies qui déterminent la mortalité à l’époque ainsi que les théories médicales qui expliquent les mesures appliquées, en essayant de dépasser certains aspects de la distinction classique d’Erwin Ackerknecht entre contagionnisme et infectionnisme. Enfin, nous abordons la formation du corps médical officiel, processus qui a entraîné des changements dans la pratique médicale. Cet intérêt pour l’hygiène publique impose l’étude de la construction de l’Etat et de sa ‘base biologique’. L’hygiène publique définit les menaces contre lesquelles elle s’érige en même temps qu’elle construit et met en sécurité la collectivité. Dans l’Etat de police du caméraliste Othon I, ces développements sont l’affaire de la bureaucratie, de l’administration, de la force publique et de la science de la police sanitaire. Son but était la construction et la mise en ordre de l’espace public, de l’espace d’action de l’Etat, qui est tout autant naturel que social. Cet établissement d’un ordre favorise la centralisation sanitaire en même temps qu’il prétend discipliner (processus de civilisation) les éléments naturels et les forces sociales pour qu’ils puissent être coordonnés sans résistances ; autrement dit, l’action d’imposer un ordre pacifie. La police sanitaire contrôle ces processus, en reconfigurant les liens que les hommes tissent entre eux, avec la géographie, avec la nature et avec leurs maladiesThis study is about the organization of public hygiene in the kingdom of Greece between 1833, when prince Otto of Bavaria ascends to the throne, and 1845, when the political and epidemiological frontiers of the kingdom are traced by a complete system of lazarettos and sanitary offices. We will firstly analyze the structures of sanitary prevention in the interior of the country (vaccinators, public health doctors, municipal doctors) as well as at its frontiers, and then we will focus on the measures against contagious diseases (such as the plague and smallpox) and against miasmas. We are also interested in examining the main diseases that determine the mortality of the period under scrutiny and the medical theories that explain the applicable sanitary measures. At the same time, we will review some of the aspects of the classical distinction of Erwin Ackerknecht between contagionism and miasmatic theory. Finally, we will study the difficult formation of an official group of medical professionals. The interest in public hygiene imposes the study of the biological construction of the state and, subsequently, of the state itself. Public hygiene defines the threats which it tries to prevent, and it creates and secures the collectivity. In the Police State of the cameralist king Otto, these developments are controlled by the bureaucracy, the administration, the public force and the science of medical police. Its purpose is to construct and order the public space, the space of state action, which is natural as well as social. This action of ordering imposes the centralization of health and at the same time it normalizes the natural elements and the social forces so that they can coordinate without resistance; in other words, the action of ordering pacifies. Medical police controls these processes by reconfiguring the ties that bind individuals with each other and with the geography, the nature and their diseases
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Mbandezi, Yamkela. "Evaluation of cytotoxic activity of gold nanoparticles naturally synthesised from South African indigenous medicinal plant extracts." University of the Western Cape, 2018. http://hdl.handle.net/11394/6786.
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>Magister Scientiae - MScNanotechnology has emerged as a promising field in the quest to address health conditions. Green nanotechnology is a fairly new branch of nanotechnology, which aims to produce and utilize nanomaterials in a way that is safe for living organisms and their environment. Plant extracts are increasingly used in the green synthesis of gold nanoparticles (AuNPs), which involves the reduction of sodium tetrachloroaurate (III) dehydrate by phytochemicals present in the plant extract. It is probable that the green synthesised AuNPs are more biocompatible than chemically synthesised AuNPs as biomolecules of plant origin are involved in the synthesis process. Therefore, this study aimed to explore various water extracts from indigenous South African plants, which included Perlagonium capitatum, Otholobium bracteolatum, Gerbera linnae, Morrella quercifolia, Searsia lucida, Phylica bubescens, Euclea racemosa, Tetragonia fruticosa, and Searsia glauca for their potential to synthesize AuNPs and to investigate their toxicity towards several microorganisms known to cause skin infections. These organisms play a significant role in delaying the healing of wounds. The antimicrobial properties of nanoparticles are increasing exploited in the production of wound treatments.
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Volpe, Andrea Sampaio. "Étimos gregos e latinos na formação de termos da medicina em Língua Portuguesa." Pontifícia Universidade Católica de São Paulo, 2015. https://tede2.pucsp.br/handle/handle/14358.
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Previous issue date: 2015-09-09This dissertation, in regard to Portuguese language field, has as its theme the study of the etymon (word root) of the Greek and Latin languages employed on a more frequent basis in the medical discursive domain. The objectives are to contribute to the studies at the Etymology field, aiming at increasing the expressive capacity as well as the degree of accuracy in the use of medical terminology of Portuguese language upon the Greek and Latin etymon knowledge. For that purpose, the most frequent terms of the Dermatology, Cardiology and Oncology specialities have been looked up in three dictionaries, in order to gain a broader understanding of their morphosemantic elements (lexemes, prefixes and suffixes), enabling the deduction of their meanings grounded on the etymological knowledge. This study has been predicated on the basis of theoretical studies developed in Terminology and Lexicology (Mario Viaro, Lídia Almeida Barros, Maria Tereza Biderman, Maria da Graça Krieger e Maria José Finatto) on the principles of the Portuguese Etymology and Morphology (Celso Cunha e Lindley Cintra; Antônio Sandmann). The obtained results indicated that: a) the Greek and Latin lexemes present a high degree of transparency in relation to their etymological meanings; therefore, facilitating the language users comprehension; b) the highest productivity in the etymon lies in the affixes, that is, there is a degree of polysemy in each of them, which justifies the semantic opacity in relation to the lexemes; c) as to the medical specialities, the scientific term presented a higher transparency in relation to their eponym. The main contribution of this study is, therefore, that the knowledge of etymological values presented in every morphic element of a term is paramount for the mastery of its signification
Este trabalho, situado na linha de história e descrição da língua, do Programa de Estudos Pós-Graduados em Língua Portuguesa, tem por tema o estudo dos étimos gregos e latinos na língua, empregados com maior frequência na formação de unidades lexicais terminológicas do português em uso no domínio discursivo da Medicina. Seus objetivos são contribuir com os estudos na área de Etimologia, visando ao aumento da capacidade expressiva e do grau de precisão no uso da terminologia médica mediante os conhecimentos dos étimos gregos e latinos. Para a realização desta pesquisa, selecionamos, a partir de três dicionários, termos científicos utilizados nas áreas de Cardiologia, Dermatologia e Oncologia que fazem uso desses étimos, a fim de analisar seus elementos morfossemânticos (lexemas, prefixos e sufixos), permitindo a dedução de seus significados a partir do conhecimento etimológico. Fundamentamos o trabalho em estudos teóricos desenvolvidos em Terminologia, Etimologia e Lexicologia, pautando-nos pelos autores Mario Viaro, Lídia Almeida Barros, Maria Tereza Biderman, Maria da Graça Krieger e Maria José Finatto; quanto à Morfologia do Português, recorremos a Celso Cunha e Lindley Cintra e Antônio Sandmann. Os resultados obtidos apontaram que: a) os lexemas gregos e latinos apresentam alto grau de transparência em relação a seus significados etimológicos, logo, de fácil compreensão por parte dos usuários da língua; b) a maior produtividade nos étimos está nos afixos, isto é, há um grau de polissemia, uma multiplicidade de sentidos na significação de cada um deles, o que justifica a opacidade semântica em relação aos lexemas; c) nas áreas da medicina, o uso do termo científico apresentou maior transparência em relação ao termo eponímico. A contribuição principal da pesquisa, portanto, é que o conhecimento dos valores etimológicos presentes em cada elemento mórfico de um termo é fundamental para o domínio de sua significação
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Mudau, Fhatuwani N. "Growth, development and chemical composition of bush tea (Athrixia phylicoides L.) as affected by seasonal nitrogen, phosphorus and potassium nutrition." Pretoria : [s.n.], 2006. http://upetd.up.ac.za/thesis/available/etd-08242006-133149.
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Hellweg, Rainer. "Stilistische Untersuchungen zu den Krankengeschichten der Epidemienbücher I und III des Corpus Hippocraticum." Bonn : Rudolf Habelt, 1985. http://catalog.hathitrust.org/api/volumes/oclc/16390624.html.
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SFAXI, MOHAMED. "Les tumeurs malignes primitives de l'intestin grele : a propos de 4 cas de leiomyosarcome." Reims, 1994. http://www.theses.fr/1994REIMM007.
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Mudau, Fhatuwani Nixwell. "Growth, development and chemical composition of bush tea (Athrixia Phylicoides L.) as affected by seasonal nitrogen, phosphorus, and potassium nutrition." Thesis, University of Pretoria, 2006. http://hdl.handle.net/2263/27502.
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Ferrer, Vázquez Mario. "Las patologías infantiles en la medicina greco-helenística. Estudio y análisis historiográfico desde la práctica de la pediatría moderna." Doctoral thesis, Universitat Jaume I, 2017. http://hdl.handle.net/10803/420881.
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La pediatría es una especialidad médica desarrollada junto a los avances sociales en relación a la infancia. En la Antigüedad, en los albores de la ciencia médica, la pediatría no existía como entidad propia, sin embargo, muchas son las referencias a la salud infantil que aparecen en los tratados médicos clásicos. Recopilando los textos conservados desde Hipócrates a Galeno, esta tesis es el resultado de la lectura pormenorizada de todos ellos, de la información de carácter pediátrico extraída de esas obras, de la importancia que la medicina infantil tuvo entre los médicos de las sociedades greco-helenística y romana, y del análisis detallado de los recursos pediátricos que aquellos médicos practicaron. Todo ello desde el punto de vista médico profesional de la pediatría actual, razonando el efecto posterior de los cambios médicos y sociales y creando un corpus pediátrico greco-helenístico de utilidad y aplicación en posteriores estudios.Pediatrics is a medical specialty that has evolved largely along with social advances in relation to childhood. In antiquity, at the dawn of medical science, pediatrics did not exist as such; however, many references to child health appear in classical medical treatises. By compiling the classical texts preserved from Hippocrates to Galen, this thesis is the result of a deep analysis of these texts concerning the pediatric information extracted from them, the importance of children's medicine among physicians of Greco-Hellenistic and Roman societies, and the pediatric resources available at that time. This analytical approach is done from the present medical-professional pediatrics point of view through reasoning of the effects of medical and social changes and by creating a Greek-Hellenistic pediatric corpus with high potential for future applications and further studies.
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Koetschet, Pauline. "Al-Râzî et la mélancolie, entre médecine et philosophie." Thesis, Paris 4, 2011. http://www.theses.fr/2011PA040078.
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La mélancolie, comprise à la fois comme une affection de l'âme apparentée à la folie et un état émotionnel caractérisé par la tristesse et la peur, occupe une place importante dans les traités médicaux écrits en arabe aux IXe et Xe siècles. À cette époque, comme dans l'Antiquité grecque, la figure du mélancolique constitue un domaine où médecins et philosophes conjuguèrent étroitement leurs efforts. En effet, les questions soulevées par la mélancolie, telles que l'interaction entre l'âme et le corps, la nature de l'âme, ou encore le siège de la partie dirigeante de l'âme, traversent les deux disciplines. Les médecins arabes s'appuient en grande partie sur les auteurs grecs, en particulier Rufus d'Éphèse et Galien. Mais la conception de la mélancolie subit aussi des variations en passant chez les auteurs arabes. La première partie de la thèse entend reconstruire la conception de la maladie chez al-Rāzī, en se fondant sur l'analyse des textes médicaux consacrés à la mélancolie chez ce dernier. Cette partie montre que le diagnostic et le traitement de la mélancolie placent le médecin face à de nombreuses difficultés méthodologiques: il doit en effet comprendre l'infinie variété des symptômes de la maladie, leur caractère à la fois physique et psychique, mais aussi expliquer comment sont découverts les pouvoirs adoucissants, échauffants et purgatifs des substances utilisées contre la maladie, et leur mode d'action dans le corps. C'est pourquoi la seconde partie de la thèse entend restituer à la conception de la mélancolie d'al-Rāzī son arrière-plan épistémologique. Elle fait apparaître qu'al-Rāzī modifie la "méthode logique" de Galien dans deux directions en apparence opposées, mais complémentaires: il replace l'expérience au centre de la méthodologie médicale, et il étend les fondements théoriques de la médecine. Cette position épistémologique conduit al-Rāzī à participer activement aux discussions philosophiques, notamment au sujet de l'âme. Dans cette perspective, la troisième partie étudie la psychologie d'al-Rāzī à partir de son interprétation de la mélancolieMelancholy—understood both as a mental disease akin to madness and a state of the mind characterised by sadness and fear—figured prominently in the works of physicians living in the Islamic world in the ninth and tenth centuries. In this context, like in Greek Antiquity, the case of the melancholic was of common concern for physicians and philosophers, because melancholy raised questions that belonged to both disciplines, for instance about the interaction between body and soul, the nature of the soul, the seat of the governing part of the soul and so on.Arabo-Islamic physicians drew heavily on the Greek tradition, and especially on Rufus of Ephesus and Galen. But the notion of melancholy evolved when it came under their scrutiny. The first part of the thesis starts by investigating al-Rāzī's medical writings, in order to understand the theoretical and practical underpinnings of melancholy in these works. This part shows that the diagnosis as well as the treatment of melancholy confronts the physician with many methodological difficulties, such as recognising the multiple symptoms of the disease, explaining their physiological and psychological foundations, but also discovering the purgative, heating and soothing power of the substances used against melancholy and exposing the way in which they fight the disease in the body. Therefore, the second part of this thesis aims at reconstructing the methodological background of those difficulties. It appears that al-Rāzī modifies Galen's "logical method" in two opposite directions: first, he increases the part of experience in medical reasoning; second, he expands the theoretical knowledge needed by the physician. This epistemological position results in al-Rāzī's active participation in philosophical debates, in particular about the soul. In this perspective, the third part of the thesis studies the role played by the interpretation of melancholy in al-Rāzī's psychology
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King, Daniel A. "Painful stories : the experience of pain and its narration in the Greek literature of the Imperial period (100-250)." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:c5509a42-cd3f-4e11-b9a1-8a3b6fa84101.
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This research project investigates the relationship between pain and the practices of explaining and narrating it to others. Current scholarship argues that the representation of suffering became, during the Imperial period, an increasingly effective and popular strategy for cultivating authority and that this explains the success of Christian culture’s representation of itself as a community of sufferers. One criticism of this approach is that the experience of pain has often been assumed, rather than analysed. Here, I investigate the nature of pain by attending to its intimate relationship with language; pain was connected to the strategies used to communicate that experience to others. I will show that writers throughout the Imperial period were concerned with questions about how to communicate pain and how that act of communication shaped, managed, and alleviated the experience. I investigate this culture along three axes. Part 1, ‘The Sublime Representation of Pain’, investigates the way different authors thought about the capacity of sublime language and rhetorical techniques such as enargeia to effectively communicate pain. I argue that for writers such as Longinus, the sublime offers an opportunity to replicate the traumatic experience of the pain sufferer in the audience or listener—pain is narrated to the audience through a traumatic communicative mode. Contrarily, I show how authors such as Plutarch and Galen were particularly concerned to desublimate the representation of pain, reducing the affective power of images of pain by promoting the audience’s conscious engagement with the text or representational medium. Part 2, ‘Medical Narratives’, examines a conflict between Galen and Aristides over the way language and narrative signified or referred to painful experiences. I show how both writers negotiate the way pain destroys and transcends ordered, structured, narrative by engaging in a process of narrative translation. I will illuminate the difference between scientific, diagnostic narratives which explain and rationalise pain experiences (in the case of Galen) and those which attempt to give witness to the nebulous, ineffable qualities of pain. In Part 3, ‘Narrating Cures’ I investigate ancient practices of psychotherapy. I show how various philosophical consolations were underpinned by an understanding of the power of pain to continually return and overwhelm the individual. I show further that the Greek romances engage in a type of talking cure: the novels use narration and story-telling to help assert the protagonists’ distance from their past traumatic experiences and, thus, allow the individual to overcome their painful past.
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Reginato, Ana Luísa. "Estudo da biodistribuição de células tronco de polpa de dente decíduo humana (CTPDDh) após o transplante intra-uterino no modelo canino (Canis lupus familiares)." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-07082013-175209/.
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O transplante intrauterino de células-tronco (TIUCT) é um método de tratamento de doenças genéticas, congênitas, hematológicas e imunológicas em um feto durante a gestação. Em pesquisa básica este modelo permite o estudo da dinâmica de migração, enxertia e estado funcional de diferentes tipos de células-tronco (CT). Estas células podem ser transplantadas em diferentes momentos do período gestacional, que pode ser dividido em três momentos do desenvolvimento fetal, sendo estes, diferentes funcionalmente. A escolha deste momento para o transplante influenciará tanto no comportamento celular quanto no resultado. Para o TIUCT são utilizadas as CT mesenquimais derivadas da medula óssea ou fetais ou hematopoiéticas. Para esta pesquisa utilizamos células-tronco derivadas da polpa dentária imatura humana (CTIPDh) as quais apresentam potencial pluripotente e propriedades imunomodulatórias. Nosso principal objetivo foi avaliar a capacidade migratória, bem como de proliferação e endereçamento (homing) das CTIPDh durante o terceiro período gestacional do desenvolvimento fetal no modelo canino. Todos os procedimentos experimentais foram elaborados sob protocolo anestésico apropriado e aprovados pelo comitê de ética da FMVZ da USP. Foram transplantadas via intraperitoneal (IP) 1x106 CTIPDh GFP+ em cada feto, durante procedimento cirúrgico de laparotomia exploratória com ultrassonografia guiada intraoperatóriamente em quatro fetos com idade gestacional aproximada de 45 dias, e outros dois fetos os quais não receberam o transplante, utilizados como controle. Avaliamos os fetos pré e pós-transplante através do ultrasson. Após sete dias, realizamos a ovário-salpingo-histerectomia (OSH) para a colheita dos fetos. Em seguida coletamos seus órgãos e tecidos os quais foram fixados em paraformoldeído a 4% e criopreservados a temperatura de -80oC. Analisamos a biodistribuição das CTIPDh dentro dos órgãos e tecidos em criocortes de 5µm sob microscopia Confocal. Constatamos o homing das CTIPDh nos órgãos derivados das linhas germinativas endodermais, ectodermais e mesodermais. No estômago e intestinos as CTIPD/GFP+ foram identificadas tanto no espaço intraglandular, como na camada muscular da mucosa; no fígado no parenquima hepático; no coração especialmente no tecido muscular do miocárdio; no cérebro nos vasos da substância branca, e cerebelo entre células de Purkinje. Na placenta estas células foram encontradas especialmente junto aos vasos. Quantificamos as CTIPD GFP+ utilizando a citometria de fluxo. Comparativamente dentre os órgãos analisados, obtivemos resultados expressivos do homing celular no miocárdio (~50%), no baço e fígado. Nossos resultados foram confirmados através das análises de imunohistoquímica e imunofluorescência utilizando os anticorpos Anti-núcleo (HuNu), Anti-CTIPD e Anti-GFP humanos. Concluímos que as CTIPDh apresentam grande potencial migratório e proliferativo após o TIUCT em fetos caninos. Estas células indiferenciadas demonstraram homing, especialmente nos tecidos: hematopoiéticos fetais (placenta, fígado e baço), tecido epitelial e glandular de órgãos, bem como de nichos perivasculares de CT. Estes dados sugerem que as CTIPD através do TIU, é uma alternativa viável, segura e promissora para o tratamento de doenças genéticas, congênitas, hematológicas e imunológicas.Intra-uterine stem cells transplantation (IUSCT) is a method for the treatment of genetic, congenital, hematological, and immunological diseases. In basic research it provides a model for studying the dynamics of migration, graft and functional status of different types of stem cells. The cells can be transplanted in different moments of gestational period, which can be divided into quarters that are not functionally equivalent. The choice of the cells and quarter where the stem cells will be applied can influence cells behavior and results of transplantation. Fetal and adult hematopoietic or bone marrow derived mesenchymal stem cells (MSCs) were mainly used for IUSCT. We previously obtained human immature dental pulp stem cell (IDPSCs), which showed pluripotent potential and immune-compatible properties. The goal of our study was to evaluate migration capacity, proliferation and homing of IDPSCs after IUSCT during the third fetal period in dogs. All experimental procedures were approved by the Ethical Committee of the School of Veterinary Medicine and Animal Science of São Paulo University and were performed under appropriate anesthesia. 1x106 of undifferentiated GFP-positive human IDPSCs were transplanted following laparotomy and intraperitoneal injection under intra-operative ultrasound control into 5 fetuses at the 45 days of gestation. Five fetuses, which did not receive IDPSCs, were used as a control. Ultrasound analyses were performed daily before collection of the fetuses. After 7 days ovarian hysterectomy was performed, fetuses were collected; organs and tissues were isolated and fixed in 4% paraformaldehyde or cryopreserved. Biodistribution of IDPSCs within the organs and tissues were analyzed on cryosections (5µm) under Confocal Microscopy. Homing of IDPSCs was observed in organs derived from three germ lines, endoderm, ectoderm and mesoderm. In stomach and in intestine GFP IDPSCs were found in intraglandular space as well as in muscularis mucosae. In liver they appeared in hepatic parenchyma; in heart in myocardium and in brain in bold vessels, in cerebellum within Purkinje cells. Using Flow cytometry assay GFP IDPSCs graft was quantified. Among the different organs an expressive homing was observed in myocardium of heart (~50%), in spleen and liver. The IDPSCs were also found in canine placenta, especially in blood vessels. These data were confirmed using anti-human nucleus (HuNu), anti-GFP and anti-IDPSCs anti-bodies. Human IDPSCs showed high migration and proliferation potential after IUSCT in dog fetuses. Undifferentiated IDPSCs demonstrated homing in fetal hematopoietic (placenta), epithelial (gastric glands) and perivascular stem cells niches. Our data suggest that IDPSCs is a new promising source for genetic, congenital, hematological, and immunological treatment for those diseases through IUSCT.
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Ermacora, Davide. "“A Snake Called Argès Slithered Into his Mouth” : the Bosom Serpent Story-Complex (Folklore, Religion, Medicine and Ethnology) from Hippocrates to Erasmus of Rotterdam." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE2010.
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L’ensemble d'histoires autour du bosom serpent se réfère à des croyances et des récits diffus qui attribuent, de manière interculturelle, le mal-être physique à l’intrusion présumée d'animaux qui entrent et vivent dans le corps du souffrant. Les recherches se sont concentrées jusqu’alors sur le folklore bosom serpent moderne et contemporain : les témoignages prémodernes ont été, de fait, largement ignorés. En me concentrant, dans cette étude, sur une vaste gamme de sources prémodernes, dont les exemples proviennent en grande partie d’Eurasie, et en adoptant une perspective comparée à la fois folklorique, historique, médicale et ethnologique, mon objectif sera de mettre en lumière ce thème d’un point de vue diachronique. Je remonterai dans le temps en suivant les occurrences des bosom serpents et j’examinerai les ramification et les adaptations variées des ethiologies traditionnelles qui les concernent. Dans leur ensemble, ces disciplines (folklore, histoire, médecine et ethnologie) offrent une apporche crédible, promeuvent la recherche collaborative et permettent l’utilisation d’une méthode scientifique basée sur une multiplicité de sources. Je montrerai qu’une grande quantité de ressemblances interculturlles, jusqu'alors considérées étrangères ou même inexplicables, font en réalité partie d'un même ensemble narratif. Ces ressemblances sont les adaptations de l’idée polymorphe, mais prédominante, centrée sur l'impossible intrusion d’animaux dans le corps humain. Les bosom serpents prémodernes, solidement ancrés dans les notions médicales et religieuses de tous les jours, furent formellement acceptés comme des faits concrets et tangibles, pouvant être appréhendés par la médecine, la démonologie et la sorcellerie. Leur charge émotive était puissante, parfois latente, et ils figurèrent probablement depuis toujours dans les traditions narratives humaines et dans les expériences personnelles. Dans ce contexte, une attention particulière sera donnée aux thèmes expérientiels et aux délires chrnoniques d’hommes et de femmes qui croient avoir été pénétrés par des animaux fantastiques. De la même manière que les bosom serpents entendus comme agents et causes de maladie, ces patients souffrant de zoopathie interne peuvent être retracé sur une longue période temporelle, jusqu’aux origines de la psychopathologieThe bosom serpent story-complex refers to widespread cross-cultural narratives and beliefs attributing physical discomfort to alleged animals entering and living in the body of the sufferer. Scholarly enquiries have concentrated on modern and contemporary bosom serpent folklore: pre-modern evidence has been largely neglected. Focusing, in this dissertation, on a vast range of pre-modern sources – examples can be found from much of Eurasia –, and adopting a folklore, a historical, a medical and an ethnological comparative perspective, my aim will be to throw more light on the theme from a diachronic point of view. I will, in fact, follow evidence for bosom serpents back through time and examine the ramifications and various adaptations of traditional aetiologies involving them. Taken together these disciplines (folklore, history, medicine and ethnology) offer a credible approach, encourage collaborative research and allow a multi-source method. I will show that a great deal of cross-cultural similarities, hitherto considered unrelated or unexplained, belong to the same story-complex. They are adaptations of the polymorphic and predominant idea of the impossible intrusion of animals into a human body. Pre-modern bosom serpents, firmly grounded in everyday medical and religious notions, were formerly accepted as concrete and tangible facts to be understood in terms of medicine, demonology, and sorcery. They had a powerful or latent emotional charge and have perhaps always figured in story-telling traditions and personal experience narratives. In this context, particular attention will be devoted to experiential themes and the chronic delusions of men and women who believed themselves to have been involuntarily penetrated by fantastic animals. Like bosom serpents cast as causative agents of disease, these suffers from internal zoopathy can be traced back in time at the beginnings of psychopathology
Il complesso di storie sul bosom serpent si riferisce a diffusi racconti e credenze che attribuiscono, cross-culturalmente, il disagio fisico a presunti animali intrusivi che entrano e vivono nel corpo del sofferente. Le indagini degli studiosi si sono concentrate sul folklore bosom serpent moderno e contemporaneo: l’evidenza pre-moderna è stata largamente ignorata. Concentrandomi, in questa dissertazione, su una vasta gamma di fonti pre-moderne – esempi possono essere rintracciati in gran parte dell’Eurasia –, e adottando una prospettiva comparata folklorica, storica, medica e etnologica, il mio obiettivo sarà quello di gettare più luce sul tema da un punto di vista diacronico. Seguirò, infatti, le evidenze di bosom serpents indietro nel tempo ed esaminerò le ramificazioni e i vari adattamenti delle eziologie tradizionali che li riguardano. Nel loro insieme queste discipline (folklore, storia, medicina ed etnologia) offrono un approccio credibile, promuovono la ricerca collaborativa e permettono l’utilizzo di un metodo scientifico basato su molteplici fonti. Mostrerò che una grande quantità di somiglianze cross-culturali, fino a questo momento considerate estranee o addirittura inspiegabili, appartengono allo stesso complesso narrativo. Esse sono adattamenti dell’idea polimorfica, ma predominante, incentrata sull’impossibile intrusione di animali nel corpo umano. I bosom serpents pre-moderni, saldamente radicati nella nozioni mediche e religiose di tutti i giorni, furono formalmente accettati come fatti concreti e tangibili intesi in termini di medicina, demonologia e stregoneria. Essi ebbero una carica emotiva potente, talvolta latente, e probabilmente figurarono da sempre nelle tradizioni umane del narrare e nelle esperienze personali. In questo contesto, un’attenzione particolare verrà dedicata ai temi esperienziali ed ai deliri cronici di uomini e donne che credettero di essere stati penetrati da animali fantastici. Esattamente come i bosom serpents intesi come agenti causa di malattia, questi pazienti sofferenti di zoopatia interna possono essere rintracciati molto indietro nel tempo nei primordi della psicopatologia
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CATAJAR, CATIL NATHALIE. "Reflexions medico-legales et ethiques sur l'utilisation des tissus foetaux dans le cadre des greffes." Lyon 1, 1992. http://www.theses.fr/1992LYO1M318.
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Mojallal, Ali. "Le tissu adipeux et ses cellules souches en chirurgie plastique et en ingénierie tissulaire : les conditions de prélèvement, de culture et de greffe." Thesis, Lyon 1, 2010. http://www.theses.fr/2010LYO10158.
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Les premières utilisations du tissu adipeux comme produit de comblement en chirurgie plastique remontent à la fin du 19ème siècle. Depuis quelques décennies, la greffe de tissu adipeux a bénéficié d'un regain d'intérêt utilisant un procédé chirurgical rigoureux. Devant la démonstration de la survie cellulaire et les bons résultats cliniques obtenus, l'utilisation de cette technique s'est élargie à tous les domaines de la chirurgie plastique. Cette technique est simple et efficace et représente actuellement le meilleur moyen de restaurer les défauts de contours et de volume. Récemment, de nouvelles indications utilisant les capacitésrégénératrices du tissu adipeux ont été décrites. Elles concernent la cicatrisation des plaies chroniques et l'amélioration des dystrophies cutanées. Mais la limite de la greffe de tissu adipeux est l'absence de site donneur disponible au prélèvement. Le tissu adipeux est aujourd'hui reconnu comme la source la plus abondante de cellules souches mésenchymateuses multipotentes. Cela a donné un nouvel essor à la médecine régénérative pour réparer, remplacer ou régénérer les tissus et organes endommagés à partirdes cellules souches. Cette régénération se fait soit in-situ après administration des cellules souches, soit après développement in-vitro d'un tissu par ingénierie. Après une présentation du tissu adipeux et ses cellules souches ainsi que leurs applications actuelles en chirurgie plastique, le but de ce travail était de : 1. de clarifier les facteurs influençant les résultats de la greffe adipeuse pour une optimisation de cette technique. 2. d'explorer les possibilités offertes par les cellules souches adipeuses pour la médecine régénérative et l'ingénierie tissulaire, en vue d'une utilisation en chirurgie plastiqueThe first uses of adipose tissue as filler in plastic surgery started in the late 19th century. In recent decades, the adipose tissue transplantation has received renewed interest using a rigorous surgical procedure. Before the demonstration of cell survival and good clinical results, the use of this technique was extended to all areas of plastic surgery. This technique is simple and effective and is currently the best way to restore the defects of contour and volume. Recently, new indications using the regenerative capacity of adipose tissue have been described. They concern the healing of chronic wounds and the improvement of skin dystrophy. But the limit of the adipose tissue graft is the lack of available donor site for harvesting. Adipose tissue is now recognized as the most abundant source of multipotent mesenchymal stem cells. This gave a boost to regenerative medicine to repair, replace or regenerate damaged tissues and organs from stem cells. This regeneration is done either in-situ after administration of stem cells, after in-vitro development of tissue engineered. After a presentation of adipose tissue and stem cells and their current applications in plastic surgery, the aim of this study was to: 1. clarify the factors influencing the results of fat transplantation to optimize this technique. 2. explore the possibilities offered by ASCs for regenerative medicine and tissue engineering, for use in plastic surgery
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Dhakal, Ram Chandra. "New Approaches To Heterocycle Synthesis: A Greener Route To Structurally Complex Protonated Azomethine Imines, And Their Use In 1,3-Dipolar Cycloadditions." ScholarWorks @ UVM, 2017. http://scholarworks.uvm.edu/graddis/777.
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1-Aza-2-azoniaallene salts are reactive intermediates that undergo [3+2] cycloaddition with many different types of multiple bonds. For the past several years, the Brewer group has studied the reactivity of these intermediates in intramolecular reactions, and have discovered that these cationic heteroallenes can react through a variety of other, mechanistically distinct, pathways to give different classes of nitrogen heterocycles. For example, prior work in the Brewer group revealed that 1-aza-2-azoniaallene salts could react in an intramolecular [4+2] cycloaddition reaction to give protonated azomethine imine salts containing a 1,2,3,4-tetrahydrocinnoline scaffold. Further study of the scope and limitations of this Diels-Alder-like reaction are described herein. These studies primarily focused on how varying the N-aryl ring and alkene substituents affected the reaction. We discovered that in several instances, the metal mediated reaction did not facilitate the cycloaddition very well, so we searched for alternative ways to facilitate the reaction. We discovered that a non-metallic Lewis acid (TMSOTf) provided very clean products with α-chloroazo compounds. I hypothesized that changing the leaving group adjacent to the azo might further improve the reaction. With this in mind, I developed a technique to prepare α-trifluoroacetoxyazo compounds by treating aryl hydrazones with trifluoroacetoxy dimethylsulfonium trifluoroacetate. This technique is compatible with all types of functional groups including nitro aryl compounds, which gave low yields of the corresponding chloroazo derivatives. Importantly, these α-trifluoroacetoxyazo compounds gave even better cycloaddition results when treated with TMSOTf, and this method is more practical, more environmentally friendly, and greener than the metal mediated technique. This process even returned sterically hindered products in high yield, and provide a dearomatized non-protonated azomethine imine salt, which further verified the proposed mechanism of the [4+2] cycloaddition. Azomethine imines are well known to undergo 1,3-dipolar cycloadditions with alkenes. We wondered if the protonated azomethine imine salts generated by the [4+2] cycloaddition could be used in a subsequent base-mediated [3+2] cycloaddition to generate structurally complex tetra- or pentacyclic products. We were pleased to find that the protonated azomethine imines indeed reacted smoothly with a variety of π-system in the presence of triethylamine to give the corresponding cycloadducts in high yields with moderate to high diastereoselectivities. In an attempt to understand the diastereoselectivity of these [3+2] cycloadditions better, I modeled them computationally.
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Baker, Patricia Anne. "Medical care for the Roman Army on the Rhine, Danube and British frontiers in the first, second and early third centuries AD." Thesis, University of Newcastle Upon Tyne, 2000. http://hdl.handle.net/10443/486.
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The study of Roman frontiers tends to concentrate on the historical development and military tactics, in construction and actions, of the Roman army. Little attention has been given to the daily life of the soldiers; and those studies that address daily organisation tend to rely upon interpretations that were made about the Roman army in the late 19th and early 20th centuries. Furthermore, the scholars who have researched this aspect tend to apply their arguments to the army as a whole, believing it to have been an homogenous group of people. The early interpretations were often based on anachronistic views that the Roman army was organised and operated in a similar manner to the military system of the time these early archaeologists were writing. One area of the organisation of the Roman army that requires greater deliberation is health care, many aspects of which are taken for granted or interpreted on the basis of understandings made by scholars early on in the development of the discipline. The more recent theories about the system of medical care in the army are also based on rather sparse supporting evidence. It is, therefore, the aim of this thesis to make a two-fold examination of the subject by examining legionary and auxiliary fortifications on the Rhine, Upper and Middle Danube and British frontiers. Queries are raised about previous scholarship in order to see if there is sufficient evidence to support the interpretations and understandings on which more recent scholarshipis based. Following this, new questions are asked of the archaeological and epigraphical material, in the context of more recent anthropological, historical and theoretical archaeological methods not previously applied in studies of Roman military medicine. The main issues are: to see if there is evidence to support the idea of a single system of medical care in the army or if the evidence shows variation within the system, either between the provinces or units; whether there was a difference in care offered to the auxiliary and legionary units; if there is evidence for civilians being treated by military doctors; and if there is evidence for cultural variation of medical practice within the units. The questions are broached by comparing the epigraphical, archaeological and architectural remains relating to medical treatment. Inscriptions mentioning doctors are examined to see if these support the idea of differences in the types of doctors employed according to frontier and unit type. In order to gain information about the cultural background of doctors and the development of medical care in the army the home of the doctors and the dates of the inscriptions are also examined. Medical instruments are employed as a source of evidence to determine the distribution and range of health care in the army. Not only are the instruments compared between fortifications and frontiers to see if there is evidence for medical variation, but they are examined for their context and deposition.It is argued that depositional processes can tell us much about how people understood medical tools and their associations with disease, wounds and death. Finally, the archaeological evidence of buildings identified as military hospitals is considered. In particular, it is questioned whether there is enough evidence to support the definition of the 'hospitals' as hospitals. Artefactual remains from within 'hospitals' are examined and compared when known, as are the plan and layout of each structure that has been recognised as a hospital. The description of Roman hospitals is frequently presented as if they were planned to serve the same functions as modem hospitals, so a comparison of these buildings and their functions, both civilian and military, is made with later (medieval and early-post-medieval) hospitals. Questions of the cultural construction of space are brought into this chapter as a means of demonstrating that the construction and use of buildings is culturally variable and not always undertaken according to a common sense or functional approach as understood in the modem west. It is apparent that our current identification of certain structures as 'hospitals' is far from secure. The thesis concludes by arguing that there is no solid evidence for the existence of a single medical system within the Roman army. A combination of military events and circumstancesa long with cultural variation in the make-up of the units provides the most plausible explanation for this pattern of variability.
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Mutyambizi, Kudakwashe. "Characterization of a murine gammaherpesvirus in vitro latency system." [New Haven, Conn. : s.n.], 2010. http://ymtdl.med.yale.edu/theses/available/etd-12042009-104512/.
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Williamson, Masen J. "Thucydides' Plague, a Narrative Aggressor." BYU ScholarsArchive, 2021. https://scholarsarchive.byu.edu/etd/8884.
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This thesis expands upon the notion that Thucydides’ plague narrative in his History of the Peloponnesian War punctuates his argument for the unique greatness of the Peloponnesian War. Through the plague, Thucydides displays the collapse of Greek society’s standards and practices. He does this by describing a plague which does not conform to 5th century BCE Greek medical ideas. Balance, human art, and divine intervention all fail in their attempts to restore the health of the individual and society. Thucydides portrays the plague as a narrative aggressor whose intent is to topple Athens and its ideals. Lucretius’ plague narrative, because it narrates the same historical moment but from a different perspective, is then discussed in order to demonstrate how other authors have used Thucydides’ technique.
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Knight, Valerie. "The 'De podagra' ('On Gout') : a pre-Gariopontean treatise excerpted from the Latin translation of the Greek 'Therapeutica' by Alexander of Tralles." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/the-de-podagra-on-gout-a-pregariopontean-treatise-excerpted-from-the-latin-translation-of-the-greek-therapeutica-by-alexander-of-tralles(a62d7ea2-fa2a-459b-83c5-cd4e379ad883).html.
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This thesis presents the first steps towards a critical edition of the ‘De podagra’ (‘On Gout’), a pre-Gariopontean treatise excerpted from the Latin translation of the Greek ‘Therapeutica’ by Alexander of Tralles. From information collated, from manuscripts and printed texts, from four textual traditions, the Greek ‘Therapeutica’, the Latin Alexander, the ‘De podagra’, and Gariopontus’ ‘Passionarius’, a provisional Latin text of the ‘De podagra’ has been produced which looks forward to the last of these traditions, Gariopontus’ ‘Passionarius’. A full English translation of the ‘De podagra’ is given. The footnotes to the provisional Latin text of the ‘De podagra’ serve to illustrate the textual tradition and highlight points of relevance for the content of the text itself. These footnotes also contain information of significance to the reconstruction of each of the other three traditions. An appendix of ‘materia medica’ and an ‘index uerborum’ are included.
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Carbonell, Abigail. "Identification of potential lead antimalarial compounds from marine microbial extracts." Honors in the Major Thesis, University of Central Florida, 2013. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/829.
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Malaria, caused by the parasite Plasmodium falciparum, has a long history as a global health threat. The vector-borne disease causes millions of deaths yearly, especially in developing countries with tropical climates that facilitate transmission. Compounding the problem is the emergence of drug-resistant strains due to overuse of outdated treatments. New compounds with antiplasmodial activity are needed to be developed as effective drugs against malaria. The hypothesis for this project is that marine microorganisms have a high likelihood of yielding novel antiplasmodial chemotypes because of their high diversity, which has not yet been explored for antimalarial development. In this project, microbes harvested and fermented by the Harbor Branch Oceanographic Institute in Fort Pierce, Florida were explored as sources for antiplasmodial natural products. Using a SYBR Green I fluorescence-based assay, 1,000 microbial extracts were screened for inhibition of the multidrug-resistant Plasmodium falciparum strain Dd2. Dose-response analysis was performed on 46 fractions from isolates whose extracts demonstrated greater-than or equal to] 70% inhibition of Dd2 at 1 micro]g/mL. To evaluate cytotoxicity, the MTS cell viability assay was used to calculate IC50 of extracts from active isolates in NIH/3T3 embryonic mouse fibroblasts. Several extracts demonstrated low IC50 in Dd2 and high IC50 in 3T3, suggesting that they contain potential lead antimalarial compounds. Extracts with high selectivity indices (potent plasmodial inhibition with low mammalian toxicity) have been prioritized for dereplication, with the goal of identifying novel active components that can be developed as antimalarial drugs.B.S.
Bachelors
Burnett School of Biomedical Sciences
Molecular Biology and Microbiology
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Tsoumpra, Natalia. "Comic leadership and power dynamics in Aristophanes." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:1b3d4779-609e-4638-81f2-2e7f0d410477.
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This thesis investigates the concept of leadership in four comedies of Aristophanes. In the first chapter (Lysistrata) I focus on the relationship of the female leadership with religious rituals and medical pathology, and I show that the power of women lies in their important biological role and their ability to conceive and (re)produce life in the context of marriage. In chapter two (Knights) I examine the operation of leadership through the alimentary and sacrificial codes of the play. I argue that the Sausage-seller gradually manifests himself as the sacrificial cook Agorakritos who sacrifices Demos. In this way he puts an end to the politics of savage, raw consumption as they were employed by Paphlagon (and, occasionally, by Demos himself), and saves the day by inaugurating a new era of political practice. In chapter three (Birds) I focus on the political competition between the former leader of the Birds, Tereus, and the newcomer Peisetairos. I argue that Peisetairos captivates his audience through the abuse of rhetoric and sophistry, and gradually adopts more brutal ways, by perverting the ritual of hospitality, committing cannibalism, and becoming sexually aggressive. In this respect, Peisetairos is assimilated to the tragic Tereus of the Sophoclean tragedy, but finally emerges as a more successful version of both the comic and the tragic Tereus. In the fourth and last chapter (Ecclesiazusae) I discuss the women’s disruption and overturn of the normal social order by focusing on the practice of cross-dressing and on love-magic rituals: the exchange of costume between the two sexes, as well as the control of magic practices by the women over men, empower women and, by contrast, disempower and ridicule men, who are finally reduced to a state of impotence, infertility and almost death.
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Oliveira, Carla Maria da Costa. "Fitoterapia na prevenção do cancro." Master's thesis, [s.n.], 2013. http://hdl.handle.net/10284/4182.
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Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências FarmacêuticasA Fitoterapia é uma terapêutica não convencional que tem vindo, ao longo das últimas décadas, a despertar o interesse da comunidade geral e científica, nomeadamente pelo seu possível papel na prevenção do cancro. Esta patologia constitui, ainda, uma das principais causas de morte no mundo. Algumas plantas têm demonstrado um potencial papel preventivo na ocorrência e/ou progressão do cancro (tal como outras doenças crónicas). Na primeira parte deste trabalho, apresenta-se uma abordagem aos conceitos de Fitoterapia, fitofármaco e fitoterápico. Segue-se uma perspetiva histórica do conceito de fitoterapia, evidenciando o crescente interesse demonstrado pela comunidade geral e científica nesta área. Como consequência deste interesse generalizado expõem-se, em seguida, aspetos importantes relacionados com a qualidade, eficácia e segurança na utilização de plantas medicinais, ou seja, critérios específicos e questões legais que envolvem e regem o seu uso. Na segunda parte desta contextualização teórica, apresenta-se uma breve exposição sobre o cancro e de seguida descreve-se, com base numa revisão da literatura, o impacto das plantas medicinais na prevenção desta patologia. No terceiro ponto, são analisadas pormenorizadamente as plantas com maior impacto na prevenção do cancro. Sobre as mesmas abordar-se-ão os seus compostos ativos, os mecanismos de ação subjacentes, efeitos secundários, interações com fármacos e, por fim, a respectiva influência na prevenção do cancro. Phytotherapy is an unconventional therapy that has, over the past decades, to arouse the interest of the scientific community generally and especially for its implication in cancer prevention. This pathology is also a major cause of death all over the world. Some plants have demonstrated a potential preventive role in the occurrence and/or progression of cancer (such as other chronic diseases). The first part of this work, consists of an approach to the concepts of phytotherapy, herbal medicine and phytochemical. Then follows a historical perspective of the concept of herbal medicine, highlighting the growing interest shown by the general community and this area. As a result of the widespread interest on phytotherapy, important aspects related to the quality, efficacy and safety in the use of medicinal plants, ie, specific criteria and legal issues that surround and govern your use were addressed. In the second part of this study, a brief exposition of the cancer is presented and then described, based on a literature review, the impact of medicinal plants in the prevention of this disease. Finally, the plants with the greatest impact on cancer prevention, we analyzed in detail. Namely, the active compounds, the effects, drug interactions, and ultimately, their influence on cancer prevention.
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Letts, Melinda. "Questioning the patient, questioning Hippocrates : Rufus of Ephesus and the limits of medical authority." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:917c8cac-6fb4-4217-95df-8e3f9db8692f.
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Rufus of Ephesus's 'Quaestiones Medicinales' is an under-studied work by one of the most respected doctors of Greco-Roman antiquity. This thesis presents a new translation - the first in English of the complete work - and a reassessment of the treatise. I propose that, far from being a simple handbook teaching doctors how to take a patient history, as has hitherto been assumed, QM is an ardent plea for doctors to recognise the limits of their own knowledge and the indispensability of questioning the patient. I argue that QM articulates the idea that the aim of medicine cannot be achieved through medical knowledge alone, and that, in constructing the patient as an essential partner in diagnosis and decisions about treatment, Rufus implies a sharing of authority between doctor and patient that is noticeably different from the emphasis that other authors, particularly the determinedly hierarchical Galen, place on securing patients' obedience, a subject on which Rufus is noticeably silent. I argue that Rufus is unusual in the clarity and candour with which he perceives and acknowledges the limits of medical knowledge, in his conceptualisation of questioning as a discursive rather than a formulaic activity, in his explicit insistence that it must be addressed directly to the patient, in his psychological concept of habits, and in his recommendation of questioning as a strategy for resolving the tension between universal theory and individual experience. I look at modern cross-cultural research into the factors that drive patient compliance, and note that chief among them is patients feeling they are partners in the treatment process. This raises the question whether and to what extent the features that drive compliance are diachronically as well as cross-culturally consistent, and whether Rufus's shared authority model is more likely to have produced successful treatment outcomes than the autocratic paradigm promoted by Galen, and subsequently absorbed into Western medical tradition, that seems to have met with so much resistance.
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Harrop-Stein, Christine. "Transitioning from a Traditional Nursing Home Environment to Green House Homes: What are Stakeholders' Attitudes Toward and Satisfaction With the Small House Care Environment." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3531.
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This dissertation research was designed as two independent research studies. The first study, qualitative, and non-experimental, aimed to examine residents’, family members’, and staff members’ (stakeholders’) satisfaction with, and attitudes toward Green House living one month prior to moving and again at one and three months after moving. Focus groups were the primary method of data collection. Thirty residents and 40 staff members transitioned to one of three Green House homes beginning January, 2013. Data collected began in December, 2012. Following each focus group, tape recordings were transcribed, and coded. Using grounded theory and the constant comparative method of analysis, themes emerged. Pre-move focus group themes revealed that stakeholders were concerned about (a) the quality of care in a system using fewer staff members and (b) the challenges associated with adjusting to a new environment. Post-move focus group themes revealed that (a) stakeholders remained concerned about staffing levels; (b) residents’ had improvements in appetite, socializing, and ambulation; and (c) staff members struggled with autonomous work teams, but preferred the Green House model of care to that of a traditional nursing home. The final model reflects a synthesis of themes from which self-efficacy beliefs were hypothesized. Themes were also linked to existing gerontological theories: Person-Environment Fit, Place-Space, Thriving, and Personhood. The second study, designed to explore the construct validity of the Person-Centered Care Attitude Tool (Per-CCat), consisted of 42 Likert-type questions divided into four sections that align with person-centered care principles. Eighty-six employees of Virginia Mennonite Retirement Community completed the survey; only 70 were analyzed due to missing data. Principal Components Analysis was the analytic approached used for these data. Bartlett’s Test of Sphericity (X2 = 2006.56, p = 0.000) and Keiser-Myers-Olkins measure of sampling adequacy (0.746) indicated that the data were factorable. The final four-factor 34-item solution aligned with the following person-centered care principals: resident autonomy, social interaction and community, work culture, and feelings toward work. Further validations studies of the Per-CCat are necessary. Given the trend in long-term care toward person-centered care, a validated survey will be useful for hiring and educating caregivers and other nursing home personnel.
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Robert, Jean-Luc. "ESTIMATION DE FONCTIONS DE GREEN DANS LES MILIEU COMPLEXE PAR DECOMPOSITION DE L'OPERATEUR RETOURNEMENT TEMPOREL: APPLICATION A L'IMAGERIE MEDICALE ET A LA CORRECTION D'ABERRATION." Phd thesis, Université Paris-Diderot - Paris VII, 2007. http://tel.archives-ouvertes.fr/tel-00324395.
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Le principal but de cette thèse est d'adapter une méthode basée sur le retournement temporel, la méthode DORT (Décomposition de l'opérateur Retournement Temporel), a l'imagerie médicale. La plupart des résultats concernent aussi d'autres domaines de l'imagerie acoustique. En effet, l'échographie médicale a subi un important développement, mais reste limite chez certains patients par le fait que les tissus sont inhomogènes. La focalisation, et donc la qualité de l'image sont fortement dégrades par la traversée de milieu inhomogènes. Pour corriger ce problème et obtenir une bonne focalisation, il est nécessaire d'estimer les fonctions de Green de points du milieu. Nous proposons une approche par retournement temporel. Nous étendons la théorie de la méthode DORT au mode d'acquisition échographique, et introduisons le model de transducteurs virtuels qui permet de traiter le problème facilement. Ensuite, nous étendons la méthode aux signaux aléatoire (speckle) qui sont les signaux majoritaires en imagerie médicale, et en proposons une interprétation statistique basée sur le théorème de Van Cittert Zernike. L'étude des objets étendus est aussi faite. Finalement, échographie médicale utilise des signaux larges bandes, alors que la méthode DORT est principalement une méthode monochromatique. Des méthodes permettant d'obtenir les fonctions de Green temporelles sont développes dans le chapitre 5. En particulier, nous présentons la décomposition de Opérateur Retournement Temporel dans le domaine temporel, ce qui fait intervenir un tenseur d'ordre 4.
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Vangala, Lakshmisri Manisha. "Size Dependent Antimicrobial Properties of Sugar Encapsulated Gold Nanoparticles." TopSCHOLAR®, 2012. http://digitalcommons.wku.edu/theses/1166.
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The antimicrobial properties of dextrose encapsulated gold nanoparticles (dGNPs) with average diameters of 25 nm, 60 nm, and 120 nm (± 5 nm) synthesized by green chemistry principles were investigated against both Gram-negative and Gram-positive bacteria. Studies were performed involving the effect of the dGNPs on the growth, morphology and the ultrastructural properties of bacteria. dGNPs were found to have significant dose dependent antibacterial activity which was directly proportional to their size and also their concentration. The microbial assays revealed the dGNPs to be bacteriostatic as well as bactericidal. The dGNPs exhibited their bactericidal action through the disruption of the bacterial cell membrane causing leakage of cytoplasmic content. The overall outcomes of this study suggest that dGNPs hold promise as a potent antimicrobial agent against a wide range of disease causing bacteria and can control and prevent possible infections or diseases.
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Aquino, Pedro Gregório Vieira. "Síntese de análogos estruturais de aminoguanidinoidrazonas planejadas como protótipos de fármacos anti-hipertensivos e protetores contra infarto do miocárdio e nova metodologia para formação de ligação C-N em meio aquoso." Universidade Federal de Alagoas, 2016. http://www.repositorio.ufal.br/handle/riufal/1863.
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The Systemic Arterial Hypertension (SAH) has a high prevalence and low rates of control and its major complication infarction. In the center of the genesis of these diseases are found the Advanced Glycation Endproducts (AGEs), whose first inhibitor described was the aminoguanidine. Amongst the therapeutic arsenal available for treating hypertension are the guanidines agonists of α2-adrenergic receptors of central action. Given the high prevalence of hypertension and high mortality rates associated with complications of the disease, this work proposes the synthesis of aminoguanidinehydrazones (AGH) with potential application for the treatment of hypertension and at another time, the creation of rigid molecular frameworks for these flexible AGHs that allow the obtention of prototypes that, retaining the anti-hypertensive activity, are useful for prevention of damage caused by ischemic heart disease. It was synthesized 20 AGHs with different aromatic substituents, which yields ranged from about 70 to 90%, using classical methods of condensation between aminoguanidine and different aromatic aldehydes, being described here for the first time the antihypertensive activity for one of them, the compound 234, also known as LQM01. Among the synthesized AGHs, four were selected to serve as the basis for the synthesis of rigid analogs, and 25 different substances were obtained with yields ranging around 40 to 90% using a variety of synthetic strategies. Of these 25 substances, 13 are new, there are no reports in the literature of its synthesis and / or pharmacological activities. In a second step, this paper also proposes a new methodology development study for the reaction of carbon-nitrogen bond formation in aqueous medium catalyzed by copper in order to contribute to the arsenal of currently available reactions for arylation of primary amines and amides, with a reaction that is easy to perform, inexpensive and environmentally friendly. Two new methods were developed, one allowing the
arylation of primary amines and other the arylation of primary and secondary amides and certain heterocyclic amines, both supplemented with TPGS using water as solvent and glucose as a reducing agent. In the arylation of primary amines model we bring here 34 examples of reactions, including different aliphatic and aromatic amines and aromatic and heteroaromatic halides with yields ranging around 50 to 90%. We also bring 34 examples of reactions with the catalyst system to arylation of
amides, including reactions with aromatic and aliphatic amides, a lactam, aryl and heteroaryl halides, and also some heterocyclic amines with yields ranging around 60 to 90%. This work allowed two important contributions, one in the field of Medicinal Chemistry, with the synthesis of novel derivatives rigid molecular frameworks of AGHs with potential application in cardiovascular disease and other contribution in the field of Synthetic Organic Chemistry, with the development of new methodologies
for C-N bond formation in an aqueous medium and with the use of sustainable additives.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
A Hipertensão Arterial Sistêmica (HAS) é uma doença com alta prevalência e baixas taxas de controle, que traz como uma das principais complicações o infarto. No centro da gênese destas doenças encontramos os chamados Produtos Finais de Glicação Avançada (AGEs), cujo primeiro inibidor descrito foi a aminoguanidina. Dentre o arsenal terapêutico disponível para o tratamento da hipertensão estão as guanidinas agonistas de receptores α2‐adrenérgicos de ação central. Tendo em vista a alta prevalência de HAS e taxas de mortalidade associadas às complicações decorrentes da doença, este trabalho propõe a síntese de aminoguanidinoidrazonas (AGHs) com aplicação potencial para o tratamento da HAS e em outro momento, a criação de arcabouços moleculares rígidos para estas AGHs flexíveis que permitam a obtenção de protótipos que, retendo a atividade anti‐hipertensiva, sejam úteis para prevenção dos danos provocados pelas doenças isquêmicas do coração. Foram sintetizadas 20 AGHs carregando diferentes substituintes aromáticos, cujos rendimentos variaram da ordem de 70 a 90%, utilizando metodologia clássica de condensação entre a aminoguanidina e diferentes aldeídos aromáticos, sendo aqui descrita pela primeira vez a atividade anti‐hipertensiva para uma delas, o composto 234, também conhecido por LQM01. Dentre as AGHs sintetizadas, quatro foram selecionadas para servirem como base para a síntese de análogos rígidos, sendo obtidas 25 substâncias diferentes, das classes dos diidroimidazois, tetraidropirimidinas, aminotriazinas, aminopirimidinas e benzotriazepinaminas, com rendimentos variando da ordem de 40 a 90%. Destas 25 substâncias, 13 são inéditas, não havendo relatos na literatura de sua obtenção e/ou atividades farmacológicas Em um segundo momento, o presente trabalho propõe também um estudo de desenvolvimento de metodologia inédita de formação de ligação carbononitrogênio em meio aquoso, catalisada por cobre com o intuito de contribuir para o arsenal de reações disponível atualmente para a arilação de aminas primárias e amidas com uma reação que seja de fácil execução, barata e ambientalmente correta. Foram desenvolvidas duas metodologias inéditas, uma permitindo a arilação de aminas primárias e outra, a arilação de amidas primárias, secundárias e algumas aminas heterocíclicas, ambas utilizando água suplementada com TPGS como solvente e glicose como agente redutor. No modelo de arilação de aminas primárias trazemos aqui 34 exemplos de reações, incluindo diferentes aminas alifáticas e aromáticas e haletos aromáticos e heteroaromáticos, cujos rendimentos variaram da ordem de 50 a 90%. Trazemos também 34 exemplos de reações com o sistema catalítico de arilação de amidas, incluindo reações com amidas aromáticas, alifáticas, uma lactama, haletos de arila e heteroarila e também algumas aminas heterocíclicas, cujos rendimentos variaram da ordem de 60 a 90%. O presente trabalho permitiu duas contribuições importantes, uma no campo da Química Medicinal, com a síntese de inovadores arcabouços moleculares rígidos derivados das AGHs com potencial aplicação em doenças cardiovasculares e outra contribuição no campo da Química Orgânica Sintética, com o desenvolvimento de novas metodologias de formação de ligação C‐N em meio aquoso e com a utilização de aditivos sustentáveis.
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LIU, Tatiana Pereira Shiu Lin. "Produção, purificação, caracterização e aplicação de tanase de Aspergillus melleus URM 5827 produzida por fermentação em estado sólido utilizando sementes de achachairú (Garcinia humilis (Vahl) C. D. Adam)." Universidade Federal Rural de Pernambuco, 2016. http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/4456.
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Tannin acylhydrolase (TAH) known as tannase (E.C:3.1.1.20) is an enzyme which hydrolizes esters and lateral bonds of hydrolizable tannins. The tannic acid is a typical hydrolizable tannin, which can be hydrolized by tannase along with glucose and gallic acid. Tannase can be obtained from vegetables, animal and microbial sources. From those, the last is the most important source to obtain the enzyme. Green tea has several substances, among which catechins are a major source of antioxidant, which help in maintaining the organism.The activity and purification of tannase produced by Aspergillus melleus URM 5827 was evaluated by semi solid fermentation using seeds of mangosteen (Garcinia humilis (Vahl) C. D. Adam) as substract. Forty two cultures fungical cultures of Aspergillus were used for qualitative selection purposes in order to verify potential for tannase production. After selecting cultures, it was performed a semi solid fermentation using seeds of mangosteen as substrate. A factorial planning (2³) was used to verify the influence of production variables such as: quantity of substrate; initial moisture and amount of tannic acid over tannase activity. The purification was evaluated by ionic change chromatography at DEAE-Sephadex. Maximum activity was produced by Aspergillus melleus URM 5827 with 452.55 units per gram of dry-based substract (U/gss) using 5.0 grams of substrate, with initial moisture of 60% and 2% of tannic acid through 48 hours fermentation. The purified enzyme has a molecular weight of 69.52 kDa on Superdex G-75, while on SDS-PAGE electrophoresis showed 66.5 kDa. As for the characterization, the optimum pH and temperature was 5.5 and 40ºC, respectively, achieving thermostability at 30ºC. Coughing increases the antioxidant activity of green tea significantly. The results obtained in this study show the promising potential of tannase produced by Aspergillus melleus URM 5827 and its use in improving the antioxidant potential of green tea.
Tanino acil hidrolase (TAH) conhecida como tanase (E.C:3.1.1.20) é uma enzima que hidrolisa ésteres e ligações laterais de taninos hidrolisáveis. O ácido tânico é um típico tanino hidrolisável, que pode ser hidrolisado por tanase em glicose e ácido gálico. A tanase pode ser obtida a partir de fontes vegetais, animais e microbianas, sendo o meio microbiológico a fonte mais importante de obtenção desta enzima. O chá verde apresenta várias substâncias, dentre elas, as catequinas que são uma importante fonte de antioxidante, que ajudam na manutenção do organismo.A atividade e a purificação de tanase produzida por Aspergillus melleus URM 5827 foi avaliada por fermentação em estado sólido utilizando como substrato sementes de achachairú (Garcinia humilis (Vahl) C. D. Adam). Foram utilizadas 42 culturas de fungos do gênero Aspergillus para seleção qualitativa das culturas com potencial para produção da tanase. Com a cultura selecionada foi realizada uma fermentação em estado sólido utilizando sementes de achachairú como substrato. Um planejamento fatorial (23) foi utilizado para analisar a influência das variáveis de produção: quantidade de substrato, umidade inicial e quantidade de ácido tânico sobre a atividade da tanase. A purificação foi avaliada por cromatografia de troca iônica em DEAE- Sephadex. A máxima atividade foi produzida por Aspergillus melleus URM 5827 com 452,55 unidades por grama de substrato na base seca (U/gss) utilizando 5,0 g de substrato, com umidade inicial de 60% e 2,0% de ácido tânico em 48 horas de fermentação. A enzima purificada apresentou peso molecular de 69,52 kDa em Superdex G-75, enquanto que em eletroforese SDS-PAGE apresentou 66,5 kDa. Quanto a caracterização, apresentou pH e temperatura ótima de 5,5 e 40ºC respectivamente, obtendo termoestabilidade a 30ºC. A atividade enzimática na presença de íons, surfactantes e inibidores de protease, foi inibida na presença dos íons ZnCl2, ZnSO4 e dos surfactantes triton X-100, SDS, reduzida com os íons CaCl2, KCl, NaCl, MgSO4, CuSO4, dos surfactantes Tween 20, Tween 80 e dos inibidores de protease EDTA e β-mercaptoetanol. A tanase aumentou a atividade antioxidante do chá verde significativamente. Os resultados obtidos no presente estudo, mostram o potencial promissor da tanase produzida por Aspergillus melleus URM 5827 e na sua utilização no aumento do potencial antioxidante do chá verde.
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Tourtier, Jean-Pierre. "Coraux de l'arc antillais et comblement osseux : apport des techniques d'imagerie et d'histologie dans l'étude du comportement in vivo chez le lapin." Bordeaux 2, 1994. http://www.theses.fr/1994BOR2M071.
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Sandberg, Sara, and Linnea Swärd. "Arbetsterapeuters arbete inom grön omsorg och dess effekter." Thesis, Luleå tekniska universitet, Hälsa och rehabilitering, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-79141.
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The connection between human and nature is fading away as society gets more modernised, with increased stress-levels as a result. Interventions based on green care have proven to give stress-reducing effects for a variety of client-groups. Using a qualitative literature study approach, the aim with this paper was to investigate how occupational therapists work within the green care area and what effects such interventions could have. The literature-search was carried out both manually and within databases. Fifteen papers were found that fulfilled the criteria for inclusion and were used for analysis. The data-analysis resulted in four categories; “Activity as goal and means”, “Investigation, evaluation and collaboration”, “Decreasing stress and increasing wellbeing” and “Sense of fellowship and belonging”. Concluding results show that occupational therapists administrates and leads programs within green care. Furthermore, the most pronounced effects were decreased stress and improved well-being. Implementing green care within occupational therapist operations has advantages and can be a valuable therapeutic tool.
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NUNES, Cristina Freitas. "Atividade virucida de um extrato etanólico de própolis verde in vitro e in vivo." Universidade Federal de Pelotas, 2011. http://repositorio.ufpel.edu.br/handle/ri/2567.
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Previous issue date: 2011-02-28Currently, the drug industry looks for new drugs based on natural products, for the production of drugs more efficient, for which the microorganisms did not show resistance to both humans and animals. A natural product that has been the subject of intense pharmacological and chemical studies by scientists for the control of diseases is propolis, a resinous substance produced by honeybees from exudates collected from different parts of the plant, which has been used for centuries in popular medicine due to its therapeutic properties. Chemical studies revealed the complex chemical composition, identifying in some cases more than 300 components including various bioactive phenolic compounds responsible for the virucidal action. This work initially describes the standardization of an ethanol extract of green propolis (EEPV), where the chemicals were identified by high performance liquid chromatography (HPLC), phytochemical characterization by thin layer chromatography (TLC), soluble solids, content of phenolics and flavonoids and antioxidant activity by 2.2 diphenil picryl hydrazyl (DPPH). The EEPV was also evaluated in vitro and in vivo for their capacity lentogenic virucidal against a strain of the virus of Newcastle disease (NDV) at two different temperatures (22 and 37 ° C), 5 incubation periods (0, 1, 2, 4 and 8 hours) of NDV in five different concentrations of EEPV (4000μg/dose, 400μg/dose, 40μg/dose, and 4μg/dose 0μg/dose). The EEPV standard is within the standards required by the MAP, with high levels of phenolics and flavonoids (12.93 and 6.05% respectively) as shown by HPLC, which identified high concentrations of phenolic acids (p-coumaric acid, hydroxycinnamic acid diprenyl , cinâmino acid derivatives), which are assigned the antibacterial, antioxidant, antiviral and virucidal. This extract showed dose-dependent virucidal activity (4000μg/dose e 400μg/dose) and time of incubation with the virus (2 hour). The inhibitory activity of EEPV against the strain of NDV lentogenic found in the present study suggests the use of this extract as an alternative to fight the infection by this virus.
Atualmente, a indústria farmacêutica busca novos medicamentos com base em produtos naturais, visando à produção de fármacos mais eficientes, para os quais os microrganismos não apresentem resistência, tanto para humanos quanto para animais. Um dos produtos naturais que tem sido objeto de intensos estudos farmacológicos e químicos por cientistas para o controle de enfermidades é a própolis, uma substância resinosa produzida por abelhas melíferas a partir de exsudatos coletados em diferentes partes das plantas, que tem sido utilizada durante séculos na medicina popular devido as suas propriedades terapêuticas. Estudos químicos revelaram a complexa composição da própolis, identificando em alguns casos mais de 300 componentes, incluindo vários compostos bioativos fenólicos responsáveis pela ação virucida. Este trabalho inicialmente descreve a padronização de um extrato etanólico de própolis verde (EEPV), onde foram identificados os compostos químicos por cromatografia liquida de alta eficiência (CLAE), caracterização fitoquímica por cromatografia em camada delgada (CCD), teor de sólidos solúveis, teor de fenóis e flavonóides totais e atividade antioxidante por 2,2 diphenil picril hidrazil(DPPH). O EEPV foi avaliado também in vitro e in vivo, quanto a sua capacidade virucida contra uma cepa lentogênica do vírus da doença de Newcastle (NDV) em duas temperaturas distintas (22 e 37°C), 5 períodos de incubação (0, 1, 2, 4 e 8 horas) do NDV em 5 concentrações de EEPV distintos (4000μg/dose, 400μg/dose, 40μg/dose, 4μg/dose e 0μg/dose). O EEPV padronizado está dentro dos padrões requisitados pelo MAPA, com altos níveis de fenóis e flavonóides totais (12.93 e 6,05% respectivamente), comprovado por CLAE, o qual identificou altas concentrações de ácidos fenólicos (ácido p-cumárico, ácido diprenil hidroxicinâmico, derivados do ácido cinâmino), os quais são atribuídos as propriedades antibacteriana, antioxidante, antiviral e virucida. Este extrato apresentou atividade virucida dependente da dose (4000μg/dose, 400μg/dose) e do tempo de incubação com o vírus (2 horas). A atividade inibitória do EEPV contra a cepa lentogênica de NDV, encontrada no presente estudo sugere a utilização deste extrato como uma alternativa no combate a infecções por este vírus.
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Bandeira, Fernando da Silva. "Bacterina de Staphylococcus aureus contendo própolis como adjuvante para controle da mastite." Universidade Federal de Pelotas, 2015. http://repositorio.ufpel.edu.br:8080/handle/prefix/3266.
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A mastite bovina é um problema sanitário mundial, com medidas de tratamento e prevenção insatisfatórias. Paralelamente, vem crescendo o interesse no uso de própolis como alternativa para tratamento das mastites, sendo ainda, objeto de estudos com finalidade de uso como adjuvante. Até o momento, porém, não foi descrito seu uso em vacinas para controle da mastite bovina. A importância do gênero Staphylococcus como agente da enfermidade é bem documentada, crescendo a necessidade de identificação da espécie do agente etiológico. A pesquisa identificou 12,6% de estafilococos coagulase positiva em mastites subclínicas na região sul do Brasil, sendo que S. aureus estando presente em 17,6% dos animais pesquisados. Dentre os isolados coagulase positiva, a frequência de S. aureus foi de 85,7%, a de S. intermedius foi de 8,5% e de S. hyicus foi 5,8%. A bactéria S. aureus utiliza vários fatores de patogenicidade para causar a infecção no hospedeiro. Foi pesquisado em bases de dados, as informações recentes sobre os principais produtos expressos e forma de atuação. Descreveu-se os principais mecanismos ligados a penetração do micro-organismo na glândula mamária, os processos que medeiam a formação do biofilme e suas estratégias de sobrevivência as respostas do hospedeiro, resultando em processos que muitas vezes tornam-se crônicos. Finalmente, é desejável a utilização de uma vacina eficiente para colaborar no controle da mastite, e dessa forma foi proposta a utilização de uma bacterina contendo extrato hidro-alcoólico de própolis verde na formulação. Comparou-se o seu efeito com uma formulação sem adição de própolis, vacina comercial e PBS esterilizado, em um trabalho conduzido em 63 bovinos. De forma semelhante, com os mesmos grupos de tratamento, mas com a adição de um grupo que recebeu apenas o extrato hidroalcoólico de própolis verde, foi conduzida uma pesquisa em 30 camundongos BALB/c. A pesquisa de anticorpos IgG em bovinos, demonstrou que tanto o tratamento contendo extrato hidroalcóolico de própolis verde quanto a bacterina sem própolis apresentaram resultados semelhantes, superiores aos tratamentos utilizando a vacina comercial e PBS, sendo que nos mesmos tratamentos, foi observada uma resposta com característica humoral inicialmente, tendendo a celular ao longo do experimento. Nos bovinos, a expressão relativa de RNAm para INF-γ, IL-2 e CXCR5 foi elevada para o grupo que recebeu a bacterina contendo extrato hidroalcoólico de própolis verde. Os resultados do teste de ELISA em camundongos, foram semelhantes aos encontrados para os bovinos. O grupo que recebeu apenas o extrato hidroalcoólico de própolis verde sem nenhuma combinação bacteriana, demonstrou resposta com predominância de IgG1 ao longo da pesquisa, semelhante aos grupos de vacina comercial e PBS. No modelo murino, a vacina comercial apresentou índices maiores de expressão de RNAm para as citocinas pesquisadas em esplenócitos. Os resultados obtidos sugerem que a bacterina contendo extrato hidroalcoólico de própolis verde apresenta potencial para atuar como ferramenta no controle da mastite bovina.
Bovine mastitis is a global health problem and many scientific advances have occurred, but the treatment and prevention of disease with existing techniques do not present satisfactory results. Similarly, there is growing interest in the use of propolis as an alternative for treatment of mastitis, also being the object of studies in order to use as an adjuvant, although so far it has not been described their use in vaccines for the control of bovine mastitis. The importance of Staphylococcus gender as disease agent is well documented, growing need for species identification of the etiologic agent. In a survey of coagulase-positive staphylococci in subclinical mastitis in southern Brazil, was finding its presence in 12.6% of cases with S. aureus was present in 17.6% of animal researched. Among the considered coagulase positive S. aureus is 85.7%, 8.5%, were S. intermedius and 5.8% were identified as S. hyicus. For the S. aureus penetrate, multiply and keep the host uses multiple pathogenic factors. Was researched in the literature to-date information on the main mechanisms expressed by the bacteria and how they operate, alone or integrated to ensure the penetration of micro-organism in the mammary gland, the processes that mediate the formation of biofilms and their coping strategies the host responses, their internalization in the cells and its continuation mechanisms, resulting in processes that often become chronic. To assist in the control of mastitis, is desirable the use of an effective vaccine and thus has been proposed the use of a bacterin containing hydroalcoholic extract of green propolis in the formulation is desirable, being compared to a similar bacterin without propolis, commercial vaccine and sterile PBS on a work carried out on 63 bovines. Similarly, with the same treatment groups and the addition of a group that received only the hydroalcoholic extract of propolis, a study was conducted on 30 BALB/c mice. The research of IgG antibodies in bovines showed that both treatment containing hydroalcoholic extract of propolis as the bacterin without propolis showed similar results and superior to commercial and PBS treatments, and the same treatment, we observed initially characteristic a humoral response with tending to cellular during throughout the experiment. In bovines, the relative expression of mRNA for INF-γ, IL-2 and CXCR5 was raised to the group receiving bacterin containing hidroalcoholic extract of green propolis. The ELISA results were similar to those of bovine in BALB/c still with the group that received only the the alcoholic extract of propolis without any bacterial combination, behaving similarly commercial and PBS, and the response was predominantly IgG1 to during the research. In the murine model, the commercial vaccine showed higher levels of mRNA expression for the studied cytokines. The results indicate that the bacterin containing alcoholic extract of propolis has the potential to act as a tool in the control of bovine mastitis in the target especie, requiring minor adjustments and a job to prove the efficiency in a challenge.