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Journal articles on the topic 'Green drug design'

Author: Grafiati

Published: 7 June 2025

Last updated: 17 July 2025

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1

Morales-Navarro, Samuel, Luis Prent-Peñaloza, Yeray A. Rodríguez Núñez, et al. "Theoretical and Experimental Approaches Aimed at Drug Design Targeting Neurodegenerative Diseases." Processes 7, no. 12 (2019): 940. http://dx.doi.org/10.3390/pr7120940.

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In recent years, green chemistry has been strengthening, showing how basic and applied sciences advance globally, protecting the environment and human health. A clear example of this evolution is the synergy that now exists between theoretical and computational methods to design new drugs in the most efficient possible way, using the minimum of reagents and obtaining the maximum yield. The development of compounds with potential therapeutic activity against multiple targets associated with neurodegenerative diseases/disorders (NDD) such as Alzheimer’s disease is a hot topic in medical chemistr

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2

Xu, Zishuo. "Research on targeted drug design based on computer technology." E3S Web of Conferences 553 (2024): 04013. http://dx.doi.org/10.1051/e3sconf/202455304013.

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This paper provides an insight into the importance and application of computer-aided drug design in today’s drug discovery and development. With the development of medicinal chemistry, molecular biology and proteomics, the synthesis and extraction pathways of many common drugs have been computer-assisted, which helps to optimize the reaction conditions, reduce the generation of waste and hazardous substances, and promote green synthesis and sustainable development. Scientists have conducted in-depth research on the pathogenesis of various diseases, especially in the field of oncology, where si

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Niazi, Sarfaraz K., and Zamara Mariam. "Computer-Aided Drug Design and Drug Discovery: A Prospective Analysis." Pharmaceuticals 17, no. 1 (2023): 22. http://dx.doi.org/10.3390/ph17010022.

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In the dynamic landscape of drug discovery, Computer-Aided Drug Design (CADD) emerges as a transformative force, bridging the realms of biology and technology. This paper overviews CADDs historical evolution, categorization into structure-based and ligand-based approaches, and its crucial role in rationalizing and expediting drug discovery. As CADD advances, incorporating diverse biological data and ensuring data privacy become paramount. Challenges persist, demanding the optimization of algorithms and robust ethical frameworks. Integrating Machine Learning and Artificial Intelligence amplifie

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Tomioka, Nobuo, and Akiko Itai. "GREEN: A program package for docking studies in rational drug design." Journal of Computer-Aided Molecular Design 8, no. 4 (1994): 347–66. http://dx.doi.org/10.1007/bf00125372.

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5

Stefanache, Alina, Alexandra Marcinschi, George-Alexandru Marin, et al. "Green Chemistry Approaches in Pharmaceutical Synthesis: Sustainable Methods for Drug Development." AppliedChem 5, no. 2 (2025): 13. https://doi.org/10.3390/appliedchem5020013.

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The Pharmaceutical Strategy for Europe addresses the environmental implications at all stages of the life cycle of pharmaceuticals, from design and production through use to disposal. In the last decade, “green chemistry” has transformed pharmaceuticals by promoting sustainability and reducing environmental impact. This review discusses the latest developments in green chemistry approaches, which are applied in drug design and production, including the concepts, innovative techniques, and methodologies. This review is notably built on over 80 documents and demonstrates the practical applicatio

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Nakano, Shogo, Shin-ichi Megro, Tadashi Hase, et al. "Computational Molecular Docking and X-ray Crystallographic Studies of Catechins in New Drug Design Strategies." Molecules 23, no. 8 (2018): 2020. http://dx.doi.org/10.3390/molecules23082020.

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Epidemiological and laboratory studies have shown that green tea and green tea catechins exert beneficial effects on a variety of diseases, including cancer, metabolic syndrome, infectious diseases, and neurodegenerative diseases. In most cases, (−)-epigallocatechin gallate (EGCG) has been shown to play a central role in these effects by green tea. Catechins from other plant sources have also shown health benefits. Many studies have revealed that the binding of EGCG and other catechins to proteins is involved in its action mechanism. Computational docking analysis (CMDA) and X-ray crystallogra

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Majee, Suman, Shilpa, Mansi Sarav, Bimal Krishna Banik, and Devalina Ray. "Recent Advances in the Green Synthesis of Active N-Heterocycles and Their Biological Activities." Pharmaceuticals 16, no. 6 (2023): 873. http://dx.doi.org/10.3390/ph16060873.

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N-heterocyclic scaffolds represent a privileged architecture in the process of drug design and development. It has widespread occurrence in synthetic and natural products, either those that are established or progressing as potent drug candidates. Additionally, numerous novel N-heterocyclic analogues with remarkable physiological significance and extended pharmaceutical applications are escalating progressively. Hence, the classical synthetic protocols need to be improvised according to modern requirements for efficient and eco-friendly approaches. Numerous methodologies and technologies emerg

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Putra, Andrianopsyah Mas Jaya, Chaidir ., Muhammad Hanafi, Yuanjiang Pan, and Arry Yanuar. "ANDROGRAPHOLIDE AND ITS DERIVATIVE - A STORY OF ANTIMALARIAL DRUG DESIGN AND SYNTHESIS." International Journal of Applied Pharmaceutics 9 (October 30, 2017): 98. http://dx.doi.org/10.22159/ijap.2017.v9s1.55_61.

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Objective: Andrographolide was found to show moderate antimalarial activity against chloroquine-resistant strain of Plasmodium falciparum (PF). Itthus becomes an interesting lead for new antimalarial drugs. This study describes a molecular docking of andrographolide and its derivative into thebest PF geranylgeranyl pyrophosphate synthase (PFGGPPS) model.Methods: A comparative modeling of PFGGPPS based on a crystal structure of Plasmodium vivax GGPPS was optimized and conducted. This modelwas considered suitable for molecular docking. Partition coefficient of andrographolide was determined to a

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Patil, Swapnil, Manojkumar M. Nitalikar, and Preeti Khulbe. "Design and Development of Nanoparticle Based Nanogel Formulation of Bixa Orellena Seed Extract." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 18, no. 1 (2025): 7842–48. https://doi.org/10.37285/ijpsn.2025.18.1.11.

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Background: Bixa orellana is known to contain Bixin, which has been known for its antifungal, antibacterial, and anti-inflammatory properties. Topical drug delivery is a widely utilized approach for achieving defined and sustained release of drugs at the intended site of action. Objective: The goal of the study is to prepare a nanoparticle based nanogel formulation from Bixa orellana seed extract. The present research work involves the synthesis of silver nanoparticles using an environmentally harmless and economically efficient method, utilizing the extract obtained from the seeds of Bixa ore

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HUA, JIANPING, CHAO SIMA, MILANA CYPERT, et al. "DYNAMICAL ANALYSIS OF DRUG EFFICACY AND MECHANISM OF ACTION USING GFP REPORTERS." Journal of Biological Systems 20, no. 04 (2012): 403–22. http://dx.doi.org/10.1142/s0218339012400049.

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Two issues are critical to the development of effective cancer-drug combinations. First, it is necessary to determine common combinations of alterations that exert strong control over proliferation and survival regulation for the general type of cancer being considered. Second, it is necessary to have a drug testing method that allows one to assess the variety of responses that can be provoked by drugs acting at key points in the cellular processes dictating proliferation and survival. Utilizing a previously reported GFP (green fluorescent protein) reporter-based technology that provides dynam

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Moshikur, Rahman Md, Rebecca L. Carrier, Muhammad Moniruzzaman, and Masahiro Goto. "Recent Advances in Biocompatible Ionic Liquids in Drug Formulation and Delivery." Pharmaceutics 15, no. 4 (2023): 1179. http://dx.doi.org/10.3390/pharmaceutics15041179.

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The development of effective drug formulations and delivery systems for newly developed or marketed drug molecules remains a significant challenge. These drugs can exhibit polymorphic conversion, poor bioavailability, and systemic toxicity, and can be difficult to formulate with traditional organic solvents due to acute toxicity. Ionic liquids (ILs) are recognized as solvents that can improve the pharmacokinetic and pharmacodynamic properties of drugs. ILs can address the operational/functional challenges associated with traditional organic solvents. However, many ILs are non-biodegradable and

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Ubaidulla Uthumansha, Mohamed Asrarullah M.H, and Mohammad Samiyullah. S. "Design And Development Of Curcumin Loaded Nanorobots For Targeting Colon Cancer." International Journal of Allied Medical Sciences and Clinical Research 12, no. 4 (2024): 426–28. https://doi.org/10.61096/ijamscr.v12.iss4.2024.426-428.

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Colorectal cancer is one of the most widespread tumors worldwide, and it is considered to be the second leading cause of death among cancer groups. Natural compounds, such as curcumin, have shown significant anti-colorectal cancer characteristics among medications that can be used to treat colorectal cancer. Targeted drug delivery systems are essential for improving the effectiveness of cancer treatment while minimizing side effects. The development of smart curcumin nanorobots for targeting colon cancer cells is a significant advancement in this field. By utilizing green synthesis of magnetit

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Tagliapietra, Silvia, Arianna Binello, Fabio Bucciol, Vladimir Trukhan, Mariachiara Colia, and Giancarlo Cravotto. "Green Enabling Technologies for Competitive Synthesis of Pharmaceutical Lead Compounds." Current Pharmaceutical Design 26, no. 44 (2020): 5700–5712. http://dx.doi.org/10.2174/1381612826999201116163951.

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Combinations of different technologies are at the heart of the development and implementation of new, innovative processes and approaches for Industry 4.0 in the field of medicinal chemistry and drug discovery. Process intensification and advances in high-throughput synthetic techniques can dramatically improve reaction rates in processes for which slow kinetics represents a bottleneck. Easier access to target-based chemical library collections offers wider access to new leads for drug development. Green enabling technologies are a reliable ally for the design of environmentally friendly synth

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Aguiar-Ricardo, Ana, Vasco D. B. Bonifácio, Teresa Casimiro, and Vanessa G. Correia. "Supercritical carbon dioxide design strategies: from drug carriers to soft killers." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 373, no. 2057 (2015): 20150009. http://dx.doi.org/10.1098/rsta.2015.0009.

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The integrated use of supercritical carbon dioxide (scCO 2 ) and micro- and nanotechnologies has enabled new sustainable strategies for the manufacturing of new medications. ‘Green’ scCO 2 -based methodologies are well suited to improve either the synthesis or materials processing leading to the assembly of three-dimensional multifunctional constructs. By using scCO 2 either as C1 feedstock or as solvent, simple, economic, efficient and clean routes can be designed to synthesize materials with unique properties such as polyurea dendrimers and oxazoline-based polymers/oligomers. These new bioco

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Wang, Ruoning, Xiaochen Gu, Jianping Zhou, et al. "Green design “bioinspired disassembly-reassembly strategy” applied for improved tumor-targeted anticancer drug delivery." Journal of Controlled Release 235 (August 2016): 134–46. http://dx.doi.org/10.1016/j.jconrel.2016.05.055.

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16

Barbinta-Patrascu, Marcela-Elisabeta, Sorina Iftimie, Nicoleta Cazacu, et al. "Bio-Entities Based on Albumin Nanoparticles and Biomimetic Cell Membranes: Design, Characterization and Biophysical Evaluation." Coatings 13, no. 4 (2023): 671. http://dx.doi.org/10.3390/coatings13040671.

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Protein-based particles are one of the most important research topics in nanomedicine, being used especially as drug delivery systems. From the wide variety of proteins, albumins offer several advantages in biomedical applications due to their special properties. Albumin nanoparticles play an important role as carriers in the drug delivery of chemical and biomolecular drugs, such as anticancer drugs; offer many advantages, such as biocompatibility and biodegradability; and are well-tolerated, without any side effects. In this work, various types of bovine serum albumin nanoparticles (BSA NPs),

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Liu, Junying. "Network pharmacology speaking to ethnopharmacology: new data on an ancient remedy." Review of Clinical Pharmacology and Pharmacokinetics - International Edition 38, Sup2 (2024): 27–29. http://dx.doi.org/10.61873/zxqs4380.

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Network pharmacology as a “green approach”, predicting metabolite behaviours chemically and biologically and guid¬ing biological experimental design, is a new strategy aiming to uncover the mechanism of action of natural products as drug candidates. It provides a powerful way to identify novel mechanisms of natural products with potential thera¬peutic effects. This approach has emerged as a powerful tool to overcome the limitations of traditional methods, such as the ability to predict the adverse effects of a drug and the likelihood of failure during clinical trials, by applying systems biolo

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18

Kausar, Ayesha, Ishaq Ahmad, Malik Maaza, and M. H. Eisa. "State-of-the-Art Nanoclay Reinforcement in Green Polymeric Nanocomposite: From Design to New Opportunities." Minerals 12, no. 12 (2022): 1495. http://dx.doi.org/10.3390/min12121495.

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Nanoclays are layered aluminosilicate nanostructures. Depending upon the chemical composition and microscopic structure, various nanoclay types have been discovered such as montmorillonite, bentonite, kaolinite, halloysite nanoclay, etc. Nanoclays have been organically modified to develop compatibility with polymers. Polymer/nanoclay nanocomposites have prompted significant breakthroughs in the field of nanocomposite technology. Green nanocomposites form an important class of nanomaterials using naturally derived degradable materials as matrix/nanofiller. This review essentially deliberates th

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Prasad, Rajendra, Sandhya Aiyer, Deepak S. Chauhan, Rohit Srivastava, and Kaliaperumal Selvaraj. "Bioresponsive carbon nano-gated multifunctional mesoporous silica for cancer theranostics." Nanoscale 8, no. 8 (2016): 4537–46. http://dx.doi.org/10.1039/c5nr06756a.

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A successful design of a novel dual functional green fluorescent CQD functionalized mesoporous silica based nano-theranostic agent for targeted bio-imaging and bio-responsive drug release has been reported. This study proves that the release of a preloaded anticancer drug is triggered by exposure to a tumor like environment which makes it an efficient theranostic system for cancer therapy.

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20

Setyawan, Eka Indra, Abdul Rohman, Erna Prawita Setyowati, and Akhmad Kharis Nugroho. "The combination of simplex lattice design and chemometrics in the formulation of green tea leaves as transdermal matrix patch." Pharmacia 68, no. (1) (2021): 275–82. https://doi.org/10.3897/pharmacia.68.e61734.

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Aim: This study was aimed to formulate a transdermal matrix patch using green tea leaf extract. Materials and methods: The transdermal matrix patch formulation was optimized by the simplex lattice design method. The correlation between responses was analyzed using chemometrics. The observed responses were: 1. the physical properties of the matrix patch, and 2. the percentage of dissolution efficiency of catechins, caffeine, and epigallocatechin gallate released from the patch. The determination of drug release kinetics was based on the curve-fitting analysis using zero-order, first-order, Higu

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M, Durga, Shilpa P, Priyadharshini I, and Dhanalakshmi S. "Green Synthesis of Silver (Ag) Nanoparticles with Green Tea Leaf, Its Characterization, and Molecular Docking Analysis against Diabetes." Saudi Journal of Biomedical Research 9, no. 06 (2024): 107–17. http://dx.doi.org/10.36348/sjbr.2024.v09i06.002.

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The Green synthesis method is proved to be one of the simplest and efficient ways for material synthesis. Silver nanoparticles were synthesized using a green synthesis method, with silver nitrate and green tea leaves as precursors. The sample is then characterized using versatile characterization techniques such as Scanning Electron Microscope (SEM), UV Spectroscopy, Raman Spectroscopy and Particle size analyser (PSA). The PSA pattern has shown that the particles are pure. The surface morphology is obtained through SEM image and it has suggested that nano particles were aggregates. The nanopar

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Dr., Amit Gosar, Sayyed Hussain Dr., Shaikh Tabrez, and Joglekar Amit. "Ionic Liquids : A New Trend in Drug Synthesis Using Green Chemistry." Trends in Pharmaceuticals and Nanotechnology 1, no. 1 (2019): 28–34. https://doi.org/10.5281/zenodo.2597862.

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<em>Environmental pollution is majorly caused by the chemical and pharmaceutical industries which have increased multifold time in the last several decades. It is the responsibility of science to design the process which will generate the less hazardous chemicals and much environmentally friendly waste. Ionic liquid finds a source of hope in reducing the organic solvent waste in coming years. These Ionic liquids may replace the organic solvents which are hazardous, toxic and non-environmentally friendly used in the synthesis of chemical compounds. This review article describes the Introduction

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Rani, Neeraj, Sanjeev, Sachin, Sukender Kumar, Sonia Narwal, and Rakesh Redu. "A Review on Green Synthesis of Nanoparticles Using Natural Gums." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 17, no. 2 (2024): 7299–312. http://dx.doi.org/10.37285/ijpsn.2024.17.2.10.

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The nanoparticles due to their nano-size can convey the drug at nanoscales and distribute it to the targeted site in a required design. Their specialized mechanism of uptake enables the enhanced bioavailability of a drug. The formulation of nanoparticles may be done using synthetic, semisynthetic, or natural polymers. Synthetic polymers employed for the development of nanoparticles can cause toxicity but the use of natural polymers can facilitate a non-toxic process for the synthesis. It is a recent trend to use natural materials in place of synthetic ones. Natural gums can be employed as natu

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H. Shariare, Mohammad, Kazi Afnan, Faria Iqbal, et al. "Development and Optimization of Epigallocatechin-3-Gallate (EGCG) Nano Phytosome Using Design of Experiment (DoE) and Their In Vivo Anti-Inflammatory Studies." Molecules 25, no. 22 (2020): 5453. http://dx.doi.org/10.3390/molecules25225453.

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Inflammation is responsible for the development of many diseases that make up a significant cause of death. The purpose of the study was to develop a novel nanophytosomal preparation of epigallocatechin-3-gallate (EGCG) and egg phospholipid complex that has a lower particle size with higher drug loading capability, physical stability and anti-inflammatory activities. The impact of different factors and material characteristics on the average particle size was studied along with the drug loading of phytosome using design of experiment (DoE). The in vivo anti-inflammatory study was evaluated usi

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Andina, Ni Kadek Devi Pradnya, Fiki Dwi Darmawan, Ni Putu Intan Satya Dewi, et al. "Application D-Optimal method on the optimization of green tea (Camellia sinensis L.) formulation." Innovation in Health for Society 1, no. 2 (2021): 26–32. http://dx.doi.org/10.31603/ihs.6331.

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Green tea leaves contain lots of polyphenols and antioxidants that can reduce cell damage and prevent premature aging. Green tea extract is made in gel preparation to make it easier to use and increase convenience. HPMC base with propylene glycol additives can increase drug release and increase drug penetration into the skin. This study aims to optimize the levels of HPMC and propylene glycol in green tea extract gel formulations using the D-optimal method and calculate the total release of polyphenols using the Franz diffusion cell method. The extract is produced by infundation. The gel prepa

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Kanagarajan, V., and M. Gopalakrishnan. "Morpholino pyrimidinyl acetamides: design, green chemical one-pot synthesis, and in vitro microbiological evaluation." Pharmaceutical Chemistry Journal 45, no. 3 (2011): 170–77. http://dx.doi.org/10.1007/s11094-011-0586-y.

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Mazyed, Eman A., Doaa A. Helal, Mahmoud M. Elkhoudary, Ahmed G. Abd Elhameed, and Mohamed Yasser. "Formulation and Optimization of Nanospanlastics for Improving the Bioavailability of Green Tea Epigallocatechin Gallate." Pharmaceuticals 14, no. 1 (2021): 68. http://dx.doi.org/10.3390/ph14010068.

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The present study aimed to investigate the potential of nanospanlastics for boosting the bioavailability of epigallocatechin gallate (EGCG). EGCG has valuable effects like anti-inflammation, anti-oxidation, and anti-tumorigenesis. Unfortunately, it has a low oral bioavailability due to its limited permeation and poor stability. To overcome these pitfalls, EGCG was fabricated as a nanospanlastic. Nanospanlastics are flexible nanovesicles that are composed of surfactants and edge activators (EAs). EAs improve the deformability of spanlastics by acting as a destabilizing factor of their vesicular

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Naga, Pranathi Abburi Narender Boggula Lakshmi Madhuri Yellapragada*. "PREPARATION OF SILVER NANOPARTICLES FROM HERBAL PLANT." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 04 (2018): 3159–67. https://doi.org/10.5281/zenodo.1238394.

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Recent advances in the field of nanotechnology have found interesting and important applications in clinical medicines and surgery. One promising application is the use of nano sized particles for the delivery of drugs, heat, radiation and other substance to specific types of cells (such as cancer cells). In view of steep rise in the infection caused by multi drugs resistant bacteria in recent years and the reduced efficacy of employed antibiotics-owing to their overuse or misuse, bacteria resistance has dramatically increased. In this respect, silver, which has long been recognized as having

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Veleva, Vesela, and Berkeley W. Cue Jr. "Benchmarking green chemistry adoption by “big pharma” and generics manufacturers." Benchmarking: An International Journal 24, no. 5 (2017): 1414–36. http://dx.doi.org/10.1108/bij-01-2016-0003.

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Purpose The purpose of this paper is to benchmark current adoption of green chemistry (GC) practices by the innovative and generic pharmaceutical companies and examine the drivers, barriers and future opportunities. Design/methodology/approach The authors examined publicly available data for the top 10 “big pharma” and top ten generic drug manufacturers. Using the IQ Green Chemistry working group framework for effective GC programs, they scored each of the 20 companies in seven key areas. Findings The study finds that generic drug companies have not embraced GC at the level of the innovative p

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Mousavi, Sarah, Shima Zare, Mahmoud Mirzaei, and Awat Feizi. "Novel Drug Design for Treatment of COVID-19: A Systematic Review of Preclinical Studies." Canadian Journal of Infectious Diseases and Medical Microbiology 2022 (September 25, 2022): 1–70. http://dx.doi.org/10.1155/2022/2044282.

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Background. Since the beginning of the novel coronavirus (SARS-CoV-2) disease outbreak, there has been an increasing interest in discovering potential therapeutic agents for this disease. In this regard, we conducted a systematic review through an overview of drug development (in silico, in vitro, and in vivo) for treating COVID-19. Methods. A systematic search was carried out in major databases including PubMed, Web of Science, Scopus, EMBASE, and Google Scholar from December 2019 to March 2021. A combination of the following terms was used: coronavirus, COVID-19, SARS-CoV-2, drug design, dru

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Jain, Dixita, Akshay Sodani, Swapnanil Ray, Pranab Ghosh, and Gouranga Nandi. "Formulation of Extended-Release Beads of Lamotrigine Based on Alginate and Cassia fistula Seed Gum by QbD Approach." Current Drug Delivery 17, no. 5 (2020): 422–37. http://dx.doi.org/10.2174/1567201817666200317124022.

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Aim: This study was focused on the formulation of the multi-unit extended-release peroral delivery device of lamotrigine for better management of epilepsy. Background: The single-unit extended-release peroral preparations often suffer from all-or-none effect. A significant number of multi-unit delivery systems have been reported as a solution to this problem. But most of them are found to be composed of synthetic, semi-synthetic or their combination having physiological toxicity as well as negative environmental impact. Therefore, fabrication and formulation of multi-unit extended-release pero

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S, Chaitanya Kumari, Selvakumar V, Naga Padma P, and Anuradha K. "Optimization Studies on Green Synthesis of Silver Nanoparticles from different Plant Extracts Using Taguchi Design." Indian Journal of Science and Technology 14, no. 38 (2021): 2888–98. https://doi.org/10.17485/IJST/v14i38.1065.

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<strong>Background/Objectives:</strong> The main objective of the present study is to screen an efficient plant extract sources for the green synthesis of silver nanoparticles (AgNPs) and optimization of various conditions for the synthesis using a statistical methodology like Taguchi design. The antimicrobial activity of the synthesized AgNPs against common wound causing dermal pathogens was also checked. <strong>Methods:</strong> The conditions for green synthesis, such as the concentration of silver nitrate, amount of plant extract, synthesis reaction time, temperature, and p

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Thomas Barden, Amanda, Júlia Medeiros Sorrentino, Nathalie Ribeiro Wingert, and Elfrides Eva Scherman Schapoval. "Miniaturized Extraction Techniques in Drug Biotransformation Studies by using Endophytic Fungi Cunninghamella elegans." Drug Analytical Research 8, no. 1 (2024): 46–53. http://dx.doi.org/10.22456/2527-2616.140446.

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In addition to predicting biotransformation in humans, drug biotransformation studies are important because they can generate active metabolites or new intermediates with possible use by the pharmaceutical industry. Endophytic fungi of the genus Cunninghamella can metabolize many drugs in a similar way to humans. The analysis of these metabolites requires prior treatment of the samples in order to obtain compatibility with the detection system and the separation technique. This work aimed to study the biotransformation of the drugs duloxetine (DLX), citalopram (CIT) and amlodipine (ANL) by end

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Lin, Qi, Yong-Peng Fu, Pei Chen, Tai-Bao Wei, and You-Ming Zhang. "Rational design, green synthesis of reaction-based dual-channel chemosensors for cyanide anion." Tetrahedron Letters 54, no. 37 (2013): 5031–34. http://dx.doi.org/10.1016/j.tetlet.2013.07.022.

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Alshatwi, Ali A., Tarique N. Hasan, Gowhar Shafi, et al. "Validation of the Antiproliferative Effects of Organic Extracts from the Green Husk ofJuglans regiaL. on PC-3 Human Prostate Cancer Cells by Assessment of Apoptosis-Related Genes." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/103026.

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With the increased use of plant-based cancer chemotherapy, exploring the antiproliferative effects of phytochemicals for anticancer drug design has gained considerable attention worldwide. This study was undertaken to investigate the effect of walnut green husk extracts on cell proliferation and to determine the possible molecular mechanism of extract-induced cell death by quantifying the expression of Bcl-2, Bax, caspases-3, and Tp53. PC-3 human prostate cancer cells. In this study, we found that green husk extracts suppressed proliferation and induced apoptosis in a dose- and time-dependent

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Kakade, Pratik, Sandip Gite, and Vandana Patravale. "Development of Atovaquone Nanosuspension: Quality by Design Approach." Current Drug Delivery 17, no. 2 (2020): 112–25. http://dx.doi.org/10.2174/1567201817666191227095019.

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Objective: The present study reports the use of MicrofluidizerTM technology to form a stable nanosuspension of atovaquone (ATQ) using quality by design (QbD) approach. Methods: The patient-centric quality target product profile and critical quality attributes (CQAs) were identified. A Box-Behnken design was employed for the optimization of dependent variables, while CQAs like particle size and PDI were evaluated as response variables. Effective optimization of ATQ nanosuspension preparation using Microfluidizer processor as a novel green technology was achieved using QbD approach. Result: The

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Rakesh, Kumar Sahu, Natique Equbal Md., Saquib Murtuza Md., et al. "A Review on Recent Development in Green Chemistry Approach for Drug Synthesis." Chemistry Research Journal 10, no. 2 (2025): 109–14. https://doi.org/10.5281/zenodo.15606131.

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Green Chemistry (GC) is a rapidly developing technology that is becoming a very appealing subject for both academic and industrial systems. Sustainable techniques in GC often include substituting hazardous solvents with innocuous ones so that the latter may be included in a particular process. Green analytical chemistry (GAC) is the most well-known field of study in GC. The use of toxic, poisonous, hazardous, and bio-accumulative chemical substances is reduced or eliminated in green chemistry, which involves the design of chemical processes and products. It is a fresh take on scientifically ba

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Dathu Reddy, Y., Ch Venkata Ramana Reddy, and P. K. Dubey. "Green approach for drug design and discovery of paracetamol analogues as potential analgesic and antipyretic agents." Green Chemistry Letters and Reviews 7, no. 1 (2014): 24–31. http://dx.doi.org/10.1080/17518253.2014.895426.

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Kaibori, Masaki, Kosuke Matsui, and Mikio Hayashi. "Theranostics Using Indocyanine Green Lactosomes." Cancers 14, no. 15 (2022): 3840. http://dx.doi.org/10.3390/cancers14153840.

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Lactosomes™ are biocompatible nanoparticles that can be used for cancer tissue imaging and drug delivery. Lactosomes are polymeric micelles formed by the self-assembly of biodegradable amphiphilic block copolymers composed of hydrophilic polysarcosine and hydrophobic poly-L-lactic acid chains. The particle size can be controlled in the range of 20 to 100 nm. Lactosomes can also be loaded with hydrophobic imaging probes and photosensitizers, such as indocyanine green. Indocyanine green-loaded lactosomes are stable for long-term circulation in the blood, allowing for accumulation in cancer tissu

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Garcia, Keth Ribeiro, Ruy Carlos Ruver Beck, Rosmary Nichele Brandalise, Venina dos Santos, and Letícia Scherer Koester. "Nanocellulose, the Green Biopolymer Trending in Pharmaceuticals: A Patent Review." Pharmaceutics 16, no. 1 (2024): 145. http://dx.doi.org/10.3390/pharmaceutics16010145.

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The use of nanocellulose in pharmaceutics is a trend that has emerged in recent years. Its inherently good mechanical properties, compared to different materials, such as its high tensile strength, high elastic modulus and high porosity, as well as its renewability and biodegradability are driving nanocellulose’s industrial use and innovations. In this sense, this study aims to conduct a search of patents from 2011 to 2023, involving applications of nanocellulose in pharmaceuticals. A patent search was carried out, employing three different patent databases: Patentscope from World Intellectual

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Serrano-Garcia, William, Irene Bonadies, Sylvia W. Thomas, and Vincenzo Guarino. "New Insights to Design Electrospun Fibers with Tunable Electrical Conductive–Semiconductive Properties." Sensors 23, no. 3 (2023): 1606. http://dx.doi.org/10.3390/s23031606.

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Fiber electronics, such as those produced by the electrospinning technique, have an extensive range of applications including electrode surfaces for batteries and sensors, energy storage, electromagnetic interference shielding, antistatic coatings, catalysts, drug delivery, tissue engineering, and smart textiles. New composite materials and blends from conductive–semiconductive polymers (C-SPs) offer high surface area-to-volume ratios with electrical tunability, making them suitable for use in fields including electronics, biofiltration, tissue engineering, biosensors, and “green polymers”. Th

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Chota, Alexander, Blassan P. George, and Heidi Abrahamse. "Recent Advances in Green Metallic Nanoparticles for Enhanced Drug Delivery in Photodynamic Therapy: A Therapeutic Approach." International Journal of Molecular Sciences 24, no. 5 (2023): 4808. http://dx.doi.org/10.3390/ijms24054808.

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Globally, cancer is one of the leading causes of death among men and women, it is characterized by the unregulated proliferation of tumor cells. Some of the common risk factors associated with cancer development include the consistent exposure of body cells to carcinogenic agents such as alcohol, tobacco, toxins, gamma rays and alpha particles. Besides the above-mentioned risk factors, conventional therapies such as radiotherapy, and chemotherapy have also been linked to the development of cancer. Over the past decade, tremendous efforts have been invested in the synthesis of eco-friendly gree

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Tazulazhar, Nurliyana, Saw Hong Loh, Marinah Mohd Ariffin, and Wan Mohd Afiq Wan Mohd Khalik. "Optimization of Effervescent Tablet-Assisted Dispersive Liquid-Liquid Microextraction with Central Composite Design for Preconcentration of Stimulant Drug." Sains Malaysiana 50, no. 1 (2021): 109–21. http://dx.doi.org/10.17576/jsm-2021-5001-12.

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The extraction efficiency of stimulant drug, namely caffeine, was investigated using a 23 central composite design. The values of optimum extraction condition were set at 468 μL of 1-dodecanol, 1 piece of effervescent tablet, and 22 °C of extraction temperature. An enrichment factor was calculated as 72 for 80 mL water sample. The run time was conducted in less than 6 min using a non-polar C18 column and an isocratic mobile phase (methanol: water of 40:60 (v/v)) at a controlled flow rate of 1 mL min-1. A good linear response was achieved in the range of 0.01-0.50 μg mL-1 (R2> 0.998). Detect

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Bueso-Bordils, Jose I., Gerardo M. Antón-Fos, Rafael Martín-Algarra, and Pedro A. Alemán-López. "Overview of Computational Toxicology Methods Applied in Drug and Green Chemical Discovery." Journal of Xenobiotics 14, no. 4 (2024): 1901–18. https://doi.org/10.3390/jox14040101.

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In the field of computational chemistry, computer models are quickly and cheaply constructed to predict toxicology hazards and results, with no need for test material or animals as these computational predictions are often based on physicochemical properties of chemical structures. Multiple methodologies are employed to support in silico assessments based on machine learning (ML) and deep learning (DL). This review introduces the development of computational toxicology, focusing on ML and DL and emphasizing their importance in the field of toxicology. A fine balance between target potency, sel

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Rodríguez, Diego F., Francisca Durán-Osorio, Yorley Duarte, et al. "Green by Design: Convergent Synthesis, Computational Analyses, and Activity Evaluation of New FXa Inhibitors Bearing Peptide Triazole Linking Units." Pharmaceutics 14, no. 1 (2021): 33. http://dx.doi.org/10.3390/pharmaceutics14010033.

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Green chemistry implementation has led to promising results in waste reduction in the pharmaceutical industry. However, the early sustainable development of pharmaceutically active compounds and ingredients remains a considerable challenge. Herein, we wish to report a green synthesis of new pharmaceutically active peptide triazoles as potent factor Xa inhibitors, an important drug target associated with the treatment of diverse cardiovascular diseases. The new inhibitors were synthesized in three steps, featuring cycloaddition reactions (high atom economy), microwave-assisted organic synthesis

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Aitouhanni, Imane, Amine Berqia, Redouane Kaiss, Habiba Bouijij, and Yassine Mouniane. "Enhancing Environmental Sustainability through Machine Learning: Predicting Drug Solubility (LogS) for Ecotoxicity Assessment and Green Pharmaceutical Design." Journal of Environmental & Earth Sciences 7, no. 4 (2025): 82–95. https://doi.org/10.30564/jees.v7i4.8866.

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Pharmaceutical pollution is becoming an increasing threat to aquatic environments since inactive compounds do not break down, and the drug products are accumulated in living organisms. The ability of a drug to dissolve in water (i.e., LogS) is an important parameter for assessing a drug's environmental fate, biovailability, and toxicity. LogS is typically measured in a laboratory setting, which can be costly and time-consuming, and does not provide the opportunity to conduct large-scale analyses. This research develops and evaluates machine learning models that can produce LogS estimates and m

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Sahoo, Biswa, Subas Dinda, BVV Kumar, Jnyanaranjan Panda, and Pathik Brahmkshatriya. "Design, Green Synthesis, and Anti-Inflammatory Activity of Schiff Base of 1,3,4-oxadiazole Analogues." Letters in Drug Design & Discovery 11, no. 1 (2013): 82–89. http://dx.doi.org/10.2174/15701808113109990041.

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Serri, Carla, Iriczalli Cruz-Maya, Irene Bonadies, et al. "Green Routes for Bio-Fabrication in Biomedical and Pharmaceutical Applications." Pharmaceutics 15, no. 6 (2023): 1744. http://dx.doi.org/10.3390/pharmaceutics15061744.

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In the last decade, significant advances in nanotechnologies, rising from increasing knowledge and refining of technical practices in green chemistry and bioengineering, enabled the design of innovative devices suitable for different biomedical applications. In particular, novel bio-sustainable methodologies are developing to fabricate drug delivery systems able to sagely mix properties of materials (i.e., biocompatibility, biodegradability) and bioactive molecules (i.e., bioavailability, selectivity, chemical stability), as a function of the current demands for the health market. The present

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Ojukwu, Uchenna, Clinton Arthur, Wisdom Jonathan, Osasere Ehigiegba, Mubaraq Yussuf, and Mariam Olawuyi. "Green Chemistry in Pharmaceutical Synthesis: Implications for Sustainable Public Health." European Journal of Scientific Research and Reviews 3, no. 1 (2025): 1. https://doi.org/10.5455/ejsrr.20250509092913.

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The pharmaceutical industry plays a vital role in improving global health, yet its traditional manufacturing processes often involve hazardous reagents, non-renewable resources, and environmentally damaging waste. Green chemistry offers a transformative approach by promoting the design of safer, more sustainable synthesis methods without compromising drug quality or efficacy. This review explores recent advancements in green chemistry techniques applied to pharmaceutical synthesis, including solvent-free reactions, biocatalysis, microwave-assisted synthesis, and the use of renewable feedstocks

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Zakharova, Pashirova, Doktorovova, et al. "Cationic Surfactants: Self-Assembly, Structure-Activity Correlation and Their Biological Applications." International Journal of Molecular Sciences 20, no. 22 (2019): 5534. http://dx.doi.org/10.3390/ijms20225534.

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The development of biotechnological protocols based on cationic surfactants is a modern trend focusing on the fabrication of antimicrobial and bioimaging agents, supramolecular catalysts, stabilizers of nanoparticles, and especially drug and gene nanocarriers. The main emphasis given to the design of novel ecologically friendly and biocompatible cationic surfactants makes it possible to avoid the drawbacks of nanoformulations preventing their entry to clinical trials. To solve the problem of toxicity various ways are proposed, including the use of mixed composition with nontoxic nonionic surfa

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