Relevant bibliographies by topics / Gross-total resection

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Academic literature on the topic 'Gross-total resection'

Author: Grafiati
Published: 3 June 2025
Last updated: 22 June 2025

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Journal articles on the topic "Gross-total resection"

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Ramaswamy, V., E. Thompson, and MD Taylor. "C.06 Surgical resection of pediatic posterior fossa tumours in the molecular era." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 43, S2 (2016): S12. http://dx.doi.org/10.1017/cjn.2016.72.

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Background: Aggressive surgical resections of posterior fossa tumours result in tremendous neurological sequelae as a result of damage to the brainstem. As such we sought to re-evaluate the role of aggressive surgical resections in the molecular era. Methods: 820 posterior fossa ependymoma and 787 medulloblastoma were genomically profiled and correlated with pertinent clinical variables. Results: Across 787 medulloblastoma cases, the value of extent of resection was greatly dampened when accounting for molecular subgroup. Near-total resections are equivalent to gross total resections across all four subgroups even when correcting for treatment. The prognostic value of a gross total resection as compared to a subtotal resection (>1.5cm2 residual) was restricted to Group 4 tumours (HR 1.26). Across 820 posterior fossa ependymoma PFA ependymoma was a very high risk group compared to PFB ependymoma, and a subtotal PFA ependymoma conferred an extremely poor prognosis. Gross totally resected PFB ependymoma could be cured with surgery alone. Prognostic nomograms in both medulloblastoma and ependymoma revealed molecular subgroup to be the most important predictor of outcome. Conclusions: The prognostic benefit of EOR for patients with medulloblastoma is marginal after accounting for molecular subgroup affiliation. In both molecular subgroups of posterior fossa ependymoma, gross total resection remains an important predictor of outcome.
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Anaizi, Amjad N., Eric A. Gantwerker, Myles L. Pensak, and Philip V. Theodosopoulos. "Facial Nerve Preservation Surgery for Koos Grade 3 and 4 Vestibular Schwannomas." Neurosurgery 75, no. 6 (2014): 671–77. http://dx.doi.org/10.1227/neu.0000000000000547.

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Abstract Background: Facial nerve preservation surgery for large vestibular schwannomas is a novel strategy for maintaining normal nerve function by allowing residual tumor adherent to this nerve or root-entry zone. Objective: To report, in a retrospective study, outcomes for large Koos grade 3 and 4 vestibular schwannomas. Methods: After surgical treatment for vestibular schwannomas in 52 patients (2004–2013), outcomes included extent of resection, postoperative hearing, and facial nerve function. Extent of resection defined as gross total, near total, or subtotal were 7 (39%), 3 (17%), and 8 (44%) in 18 patients after retrosigmoid approaches, respectively, and 10 (29.5%), 9 (26.5%), and 15 (44%) for 34 patients after translabyrinthine approaches, respectively. Results: Hearing was preserved in 1 (20%) of 5 gross total, 0 of 2 near-total, and 1 (33%) of 3 subtotal resections. Good long-term facial nerve function (House-Brackmann grades of I and II) was achieved in 16 of 17 gross total (94%), 11 of 12 near-total (92%), and 21 of 23 subtotal (91%) resections. Long-term tumor control was 100% for gross total, 92% for near-total, and 83% for subtotal resections. Postoperative radiation therapy was delivered to 9 subtotal resection patients and 1 near-total resection patient. Follow-up averaged 33 months. Conclusion: Our findings support facial nerve preservation surgery in becoming the new standard for acoustic neuroma treatment. Maximizing resection and close postoperative radiographic follow-up enable early identification of tumors that will progress to radiosurgical treatment. This sequential approach can lead to combined optimal facial nerve function and effective tumor control rates.
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DeCou, James M., Marc G. Schlatter, Deanna S. Mitchell, and Randel S. Abrams. "Primary Thoracoscopic Gross Total Resection of Neuroblastoma." Journal of Laparoendoscopic & Advanced Surgical Techniques 15, no. 5 (2005): 470–73. http://dx.doi.org/10.1089/lap.2005.15.470.

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Katsevman, Gennadiy A., Ryan C. Turner, Ogaga Urhie, Joseph L. Voelker, and Sanjay Bhatia. "Utility of sodium fluorescein for achieving resection targets in glioblastoma: increased gross- or near-total resections and prolonged survival." Journal of Neurosurgery 132, no. 3 (2020): 914–20. http://dx.doi.org/10.3171/2018.10.jns181174.

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OBJECTIVEIt is commonly reported that achieving gross-total resection of contrast-enhancing areas in patients with glioblastoma (GBM) improves overall survival. Efforts to achieve an improved resection have included the use of both imaging and pharmacological adjuvants. The authors sought to investigate the role of sodium fluorescein in improving the rates of gross-total resection of GBM and to assess whether patients undergoing resection with fluorescein have improved survival compared to patients undergoing resection without fluorescein.METHODSA retrospective chart review was performed on 57 consecutive patients undergoing 64 surgeries with sodium fluorescein to treat newly diagnosed or recurrent GBMs from May 2014 to June 2017 at a teaching institution. Outcomes were compared to those in patients with GBMs who underwent resection without fluorescein.RESULTSComplete or near-total (≥ 98%) resection was achieved in 73% (47/64) of fluorescein cases. Of 42 cases thought not to be amenable to complete resection, 10 procedures (24%) resulted in gross-total resection and 15 (36%) resulted in near-total resection following the use of sodium fluorescein. No patients developed any local or systemic side effects after fluorescein injection. Patients undergoing resection with sodium fluorescein, compared to the non–fluorescein-treated group, had increased rates of gross- or near-total resection (73% vs 53%, respectively; p < 0.05) as well as improved median survival (78 weeks vs 60 weeks, respectively; p < 0.360).CONCLUSIONSThis study is the largest case series to date demonstrating the beneficial effect of utilizing sodium fluorescein as an adjunct in GBM resection. Sodium fluorescein facilitated resection in cases in which it was employed, including dominant-side resections particularly near speech and motor regions. The cohort of patients in which sodium fluorescein was utilized had statistically significantly increased rates of gross- or near-total resection. Additionally, the fluorescein group demonstrated prolonged median survival, although this was not statistically significant. This work demonstrates the promise of an affordable and easy-to-implement strategy for improving rates of total resection of contrast-enhancing areas in patients with GBM.
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D’Souza, Preston, Erin K. Barr, Seshadri D. Thirumala, Roy Jacob, and Laszlo Nagy. "Pigmented epithelioid melanocytoma: a rare lytic bone lesion involving intradural extension and subtotal resection in a 14-month-old girl." Journal of Neurosurgery: Pediatrics 25, no. 6 (2020): 625–28. http://dx.doi.org/10.3171/2020.1.peds19359.

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Pigmented epithelioid melanocytomas (PEMs) are low-grade, intermediate-type borderline melanocytic tumors with limited metastatic potential. To date, PEMs have been treated via gross-total resections. Postoperative recurrence and mortality are rare. This case highlights a unique presentation of a PEM that involved bone destruction and intradural infiltration, which required a subtotal resection. To the authors’ knowledge, this is the first report of a PEM extending through the dura and necessitating subtotal resection, which is contrary to the standard of care, gross-total resection. Surveillance imaging 10 months after resection remained negative for clinical and radiological recurrence.
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Baik, Seung Hyun, So Yeon Kim, Young Cheol Na, and Jin Mo Cho. "Supratotal Resection of Glioblastoma: Better Survival Outcome than Gross Total Resection." Journal of Personalized Medicine 13, no. 3 (2023): 383. http://dx.doi.org/10.3390/jpm13030383.

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Objective: Supratotal resection (SupTR) of glioblastoma allows for a superior long-term disease control and increases overall survival. On the other hand, aggressive conventional approaches, including gross total resections (GTR), are limited by the impairment risk of adjacent eloquent areas, which may cause severe postoperative functional morbidity. This study aimed to analyze institutional cases with respect to the potential survival benefits of additional resection, including lobectomy, as a paradigm for SupTR in patients of glioblastoma. Methods: Between 2014 and 2018, 15 patients with glioblastoma underwent SupTR (GTR and additional lobectomy) at the authors’ institution. The postoperative Karnofsky performance score (KPS), progression-free survival (PFS), and overall survival (OS) were analyzed for the patients. Results: Patients with SupTR showed significantly prolonged PFS and OS. The median PFS and OS values for the entire study group were 33.5 months (95% confidence intervals (CI): 18.5–57.3 months) and 49.1 months (95% CI: 24.7–86.6 months), respectively. Multivariate analysis revealed that the O6-DNA-methylguanine methyltransferase (MGMT) promoter methylation status was the only predictor for both superior PFS (p = 0.03, OR 5.7, 95% CI 1.0–49.8) and OS (p = 0.04, OR 6.5, 95% CI 1.1–40.2). There was no significant difference between the pre- and postoperative KPS scores. Conclusions: Our results suggest that SupTR with lobectomy allows for a superior PFS and OS without negatively affecting patient performance. However, due to the small number of patients, further studies that include more patients are needed.
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Schucht, Philippe, Jürgen Beck, Janine Abu-Isa, et al. "Gross Total Resection Rates in Contemporary Glioblastoma Surgery." Neurosurgery 71, no. 5 (2012): 927–36. http://dx.doi.org/10.1227/neu.0b013e31826d1e6b.

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Abstract BACKGROUND: Complete resection of contrast-enhancing tumor has been recognized as an important prognostic factor in patients with glioblastoma and is a primary goal of surgery. Various intraoperative technologies have recently been introduced to improve glioma surgery. OBJECTIVE: To evaluate the impact of using 5-aminolevulinic acid and intraoperative mapping and monitoring on the rate of complete resection of enhancing tumor (CRET), gross total resection (GTR), and new neurological deficits as part of an institutional protocol. METHODS: One hundred three consecutive patients underwent resection of glioblastoma from August 2008 to November 2010. Eligibility for CRET was based on the initial magnetic resonance imaging assessed by 2 reviewers. The primary end point was the number of patients with CRET and GTR. Secondary end points were volume of residual contrast-enhancing tissue and new postoperative neurological deficits. RESULTS: Fifty-three patients were eligible for GTR/CRET (n = 43 newly diagnosed glioblastoma, n = 10 recurrent); 13 additional patients received surgery for GTR/CRET-ineligible glioblastoma. GTR was achieved in 96% of patients (n = 51, no residual enhancement > 0.175 cm3); CRET was achieved in 89% (n = 47, no residual enhancement). Postoperatively, 2 patients experienced worsening of preoperative hemianopia, 1 patient had a new mild hemiparesis, and another patient sustained sensory deficits. CONCLUSION: Using 5-aminolevulinic acid imaging and intraoperative mapping/monitoring together leads to a high rate of CRET and an increased rate of GTR compared with the literature without increasing the rate of permanent morbidity. The combination of safety and resection-enhancing intraoperative technologies was likely to be the major drivers for this high rate of CRET/GTR.
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Rodgers, Brian, Aaron Metrailer, Christopher Metz, Seilesh Babu, Dennis Bojrab, and Michael LaRouere. "Acoustic Neuroma Recurrence after Translabyrinthine Gross-Total Resection." Journal of Neurological Surgery Part B: Skull Base 78, S 01 (2017): S1—S156. http://dx.doi.org/10.1055/s-0037-1600544.

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Schneider, Julia R., Amrit K. Chiluwal, Orseola Arapi, Kevin Kwan, and Amir R. Dehdashti. "Near Total Versus Gross Total Resection of Large Vestibular Schwannomas: Facial Nerve Outcome." Operative Neurosurgery 19, no. 4 (2020): 414–21. http://dx.doi.org/10.1093/ons/opaa056.

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Abstract BACKGROUND Large vestibular schwannomas (VSs) with brainstem compression are generally reserved for surgical resection. Surgical aggressiveness must be balanced with morbidity from cranial nerve injury. The purpose of the present investigation is to evaluate the clinical presentation, management modality, and patient outcomes following near total resection (NTR) vs gross total resection (GTR) of large VSs. OBJECTIVE To assess facial nerve outcome differences between GTR and NTR patient cohorts. METHODS Between January 2010 and March 2018, a retrospective chart review was completed to capture patients continuously who had VSs with Hannover grades T4a and T4b. NTR was decided upon intraoperatively. Primary data points were collected, including preoperative symptoms, tumor size, extent of resection, and postoperative neurological outcome. RESULTS A total of 37 patients underwent surgery for treatment of large and giant (grade 4a and 4b) VSs. Facial nerve integrity was preserved in 36 patients (97%) at the completion of surgery. A total of 27 patients underwent complete resection, and 10 had near total (>95%) resection. Among patients with GTR, 78% (21/27) had House-Brackmann (HB) grade I-II facial nerve function at follow-up, whereas 100% (10/10) of the group with NTR had HB grade I-II facial nerve function. Risk of meningitis, cerebrospinal fluid leak, and sinus thromboses were not statistically different between the 2 groups. There was no stroke, brainstem injury, or death. The mean follow-up was 36 mo. CONCLUSION NTR seems to offer a benefit in terms of facial nerve functional outcome compared to GTR in surgical management of large VSs without significant risk of recurrence.
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Li, Yan Michael, Dima Suki, Kenneth Hess, and Raymond Sawaya. "The influence of maximum safe resection of glioblastoma on survival in 1229 patients: Can we do better than gross-total resection?" Journal of Neurosurgery 124, no. 4 (2016): 977–88. http://dx.doi.org/10.3171/2015.5.jns142087.

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OBJECT Glioblastoma multiforme (GBM) is the most common and deadliest primary brain tumor. The value of extent of resection (EOR) in improving survival in patients with GBM has been repeatedly confirmed, with more extensive resections providing added advantages. The authors reviewed the survival of patients with significant EORs and assessed the relative benefit/risk of resecting 100% of the MRI region showing contrast-enhancement with or without additional resection of the surrounding FLAIR abnormality region, and they assessed the relative benefit/risk of performing this additional resection. METHODS The study cohort included 1229 patients with histologically verified GBM in whom ≥ 78% resection was achieved at The University of Texas MD Anderson Cancer Center between June 1993 and December 2012. Patients with > 1 tumor and those 80 years old or older were excluded. The survival of patients having 100% removal of the contrast-enhancing tumor, with or without additional resection of the surrounding FLAIR abnormality region, was compared with that of patients undergoing 78% to < 100% EOR of the enhancing mass. Within the first subgroup, the survival durations of patients with and without resection of the surrounding FLAIR abnormality were subsequently compared. The data on patients and their tumor characteristics were collected prospectively. The incidence of 30-day postoperative complications (overall and neurological) was noted. RESULTS Complete resection of the T1 contrast-enhancing tumor volume was achieved in 876 patients (71%). The median survival time for these patients (15.2 months) was significantly longer than that for patients undergoing less than complete resection (9.8 months; p < 0.001). This survival advantage was achieved without an increase in the risk of overall or neurological postoperative deficits and after correcting for established prognostic factors including age, Karnofsky Performance Scale score, preoperative contrast-enhancing tumor volume, presence of cyst, and prior treatment status (HR 1.53, 95% CI 1.33–1.77, p < 0.001). The effect remained essentially unchanged when data from previously treated and previously untreated groups of patients were analyzed separately. Additional analyses showed that the resection of ≥ 53.21% of the surrounding FLAIR abnormality beyond the 100% contrast-enhancing resection was associated with a significant prolongation of survival compared with that following less extensive resections (median survival times 20.7 and 15.5 months, respectively; p < 0.001). In the multivariate analysis, the previously treated group with < 53.21% resection had significantly shorter survival than the 3 other groups (that is, previously treated patients who underwent FLAIR resection ≥ 53.21%, previously untreated patients who underwent FLAIR resection < 53.21%, and previously untreated patients who underwent FLAIR resection ≥ 53.21%); the previously untreated group with ≥ 53.21% resection had the longest survival. CONCLUSIONS What is believed to be the largest single-center series of GBM patients with extensive tumor resections, this study supports the established association between EOR and survival and presents additional data that pushing the boundary of a conventional 100% resection by the additional removal of a significant portion of the FLAIR abnormality region, when safely feasible, may result in the prolongation of survival without significant increases in overall or neurological postoperative morbidity. Additional supportive evidence is warranted.
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Books on the topic "Gross-total resection"

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Klimo, Paul, and Nir Shimony. Ependymomas. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190696696.003.0026.

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Pediatric posterior fossa tumors are usually ependymoma, pilocytic astrocytoma, or medulloblastoma. Ependymoma appears well-demarcated with heterogeneous enhancement on magnetic resonance imaging (MRI). Full neural axis MRI is indicated to assess for metastatic disease. Management is typically surgical resection of the tumor, with consideration for cerebrospinal fluid diversion if patients present with severe hydrocephalus. Extent of resection of the tumor is the most important factor in predicting recurrence and overall survival, and gross total resection is ideal. Infratentorial ependymomas have 2 molecular subtypes, which has implications for responsiveness to adjuvant therapy and prognosis. Infratentorial ependymomas are biologically different from supratentorial ependymomas. Postoperative radiation improves local control.
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Majmundar, Neil, and James K. Liu. Ventricular Tumors. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190696696.003.0009.

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Central neurocytomas are rare benign tumors that are typically located in the lateral ventricles. Because they are typically intraventricular, these tumors tend to present clinically with hydrocephalus. Currently, surgical removal with a gross-total resection is the treatment of choice. Various radiotherapy techniques, including both conventional radiotherapy and stereotactic radiosurgery, have been shown to be useful in cases of residual tumor after subtotal resection and tumor recurrence. This chapter presents a clinical case of central neurocytoma that demonstrates the typical clinical and radiological findings, as well as the diagnostic workup and surgical management of these tumors.
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Weaver, Bradley D., and Randy L. Jensen. Hemangiopericytoma. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190696696.003.0012.

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Hemangiopericytoma (HPC) represents a rare, diagnostically challenging tumor for neurosurgical oncologists. Often, HPC appears as a dural-based, extra-axial mass lacking the characteristic hyperostosis and calcification of meningioma. Rapidly growing unconfirmed meningioma-like masses warrant increased suspicion of HPC. These tumors differ significantly from meningiomas in natural history and implications for patient morbidity and mortality. Histopathological analysis is required for proper diagnosis. MRI with and without contrast is recommended for operative planning, and angiography and preoperative embolization may be necessary for highly vascular HPCs. Operative goals include maximal, safe gross total resection. Evidence suggests adjuvant radiosurgery or radiation therapy benefits patients regardless of the extent of surgical resection.
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Singh, Harminder, Smeer Salam, and Theodore H. Schwartz. Endocrine Silent Pituitary Tumors. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190696696.003.0016.

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Pituitary adenomas are the most common intracranial neoplasms in adults, with a prevalence of 7% to 17%. Clinically, they can be divided into 2 categories based on whether they secrete pituitary hormones: functional (secretory) and nonfunctional (nonsecretory or endocrine silent) adenomas. The biologic latency of nonfunctional (endocrine silent) adenomas makes them usually diagnosed at the stage of macro (>1 cm) and giant (>4 cm) adenomas. Because these tumors are nonfunctioning, their primary symptoms are due to mass effect, particularly on the optic chiasm and normal pituitary gland and stalk superiorly, and the cavernous sinus laterally. Visual field disturbance is the most common presenting complaint, followed by pituitary dysfunction and headaches. Surgical outcomes, therefore, are aimed at determining visual outcome in addition to rates of gross total resection, recurrence, and postoperative pituitary dysfunction. Several recent case series have documented the increased success of the endonasal endoscopic transsphenoidal approach for resecting nonfunctioning pituitary adenomas, particularly in relation to the classic open cranial and microsurgical transsphenoidal techniques.
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Book chapters on the topic "Gross-total resection"

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Kramarz, Michael J., Eric M. Jackson, Adam C. Resnick, and Phillip B. Storm. "Early Childhood Clival-C2 Atypical Teratoid/Rhabdoid Tumor: Gross Total Resection Followed by Aggressive Chemotherapy and Radiation." In Pediatric Cancer, Volume 3. Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-94-007-4528-5_7.

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"Need for Gross Total Resection of Cranial Base Meningiomas." In Controversies in Neuro-Oncology, edited by Alfredo Quiñones-Hinojosa and Shaan M. Raza. Georg Thieme Verlag, 2014. http://dx.doi.org/10.1055/b-0034-91040.

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"The Role of Gross Total Resection in Low-Grade Gliomas." In Controversies in Neuro-Oncology, edited by Alfredo Quiñones-Hinojosa and Shaan M. Raza. Georg Thieme Verlag, 2014. http://dx.doi.org/10.1055/b-0034-91010.

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Garcia-Navarrete, Roberto, Javier Terrazo-Lluch, Alfonso Marhx-Bracho, et al. "Awake Craniotomy and Brain Mapping for Brain Tumor Resection in Pediatric Patients." In Central Nervous System Tumors. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.97101.

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Brain tumor resection in pediatric patients constitutes a real challenge. In order to improve survival and to preserve neurological function, we will further on describe our experience with awake craniotomy and functional mapping for brain tumor resection in pediatric patients. Although our experience with this technique was relatively short, we did not observe complications, and a gross total resection was successfully achieved in all cases. In the postoperative period we did not find any new deficiency in our patients. We observed functional recovery - motor and sensitive aphasia, motor strength improvement in hemiplegic patients, and recovery of neurodevelopmental milestones during follow-up. In our experience, the use of awake craniotomy and brain mapping for brain tumor resection in pediatric patients is truly safe and reliable.
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Boop, Frederick A., and Jimmy Ming-Jung Chuang. "Posterior Fossa Ependymoma." In Pediatric Neurosurgery. Oxford University Press, 2019. http://dx.doi.org/10.1093/med/9780190617073.003.0025.

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Pediatric posterior fossa ependymomas are typically well-delineated masses with heterogenous enhancement arising from the floor, lateral aspect, or roof of the fourth ventricle. Growth of tumor into the posterior fossa subarachnoid spaces, particularly into the foramen of Magendie and the cerebellopontine angles via the foramen of Luschka, is a radiological hallmark of this tumor. Clinical findings of elevated intracranial pressure and obstructive hydrocephalus are common at presentation. The current standard of care for children with ependymoma consists of gross total resection with subsequent focal radiotherapy. The extent of resection is the single most important determinant of outcome. Hydrocephalus typically resolves after resection, and it is uncommon to require cerebrospinal shunt placement after tumor removal.
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Simon, Matthias, and Alexander Grote. "Glioneuronal and other epilepsy-associated tumours." In Oxford Textbook of Neurological Surgery, edited by Ramez W. Kirollos, Adel Helmy, Simon Thomson, and Peter J. A. Hutchinson. Oxford University Press, 2019. http://dx.doi.org/10.1093/med/9780198746706.003.0010.

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Patients with (glio)neuronal brain tumours are rare. The most common variants, hat is, gangliogliomas and dysembryoplastic neuroepithelial tumours (DNTs), frequently present with pharmacoresistant epilepsy. Together with certain other tumour types associated with chronic epilepsy (including selected cases with diffuse gliomas WHO grade II/III) these entities have historically been referred to as LEATs (long-term epilepsy-associated tumours). LEATs share a very benign clinical course and rarely recur following a gross total resection. More than 80% of patients can expect to become seizure-free following epilepsy surgery (i.e. resection of the epileptogenic zone rather than tumour removal only). Hippocampal resections may improve the seizure outcome in cases with mesial temporal lobe epilepsy, but may also carry a concurrent risk of neuropsychological deficits. In contrast, oncological issues dominate the clinical course of LEATs and glioneuronal tumour variants if encountered outside the setting of refractory epilepsy. The dysplastic cerebellar gangliocytoma (L’Hermitte-Duclos disease, LDD) is the major central nervous system manifestation of Cowden disease. Its neoplastic nature is questionable.
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Baucher, Guillaume, Lucas Troude, and Pierre-Hugues Roche. "Spheno-Orbital Meningiomas." In Skull Base Surgery [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.101983.

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Spheno-orbital meningiomas are mainly defined as primary en plaque tumors of the lesser and greater sphenoid wings, invading the underlying bone and adjacent anatomical structures. The patients, mostly women in their fifties, generally present with a progressive, unilateral, and nonpulsatile proptosis, often associated with cosmetic deformity and optic nerve damage. Surgical resection is currently the gold standard of treatment in case of optic neuropathy, significant symptoms, or radiological progression. The surgical strategy should take into account the morphology of the tumor, its epicenter at the level of the sphenoid wing, and the invasion of adjacent anatomical structures. Surgery stabilizes or improves visual function and oculomotricity in most cases but it is rare that the proptosis recovers completely. Gross total resection is hard to achieve considering the complex anatomy of the spheno-orbital region and the risk of inducing cranial nerve deficits. Rare cases of WHO grade II or III meningiomas warrant adjuvant radiotherapy. Tumor residues after subtotal resections of WHO grade I meningiomas are first radiologically monitored and then treated by stereotactic radiosurgery in case of progression.
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Dai Duong, Ha, and Linh Duy Nguyen. "Glioma Resection in Functional Areas Using Diffusion Tensor Imaging-Based Tractography and Neuro-Navigation." In Advances in Neurosurgical Procedures - Unveiling New Horizons [Working Title]. IntechOpen, 2025. https://doi.org/10.5772/intechopen.1008995.

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Gliomas located in critical brain regions, such as the motor and language areas, present significant challenges in neurosurgery due to the elevated risk of causing neurological deficits during intervention. Diffusion tensor imaging (DTI)-based tractography has emerged as a valuable tool for both preoperative planning and intraoperative navigation, facilitating the identification of essential white matter tracts to help preserve functional integrity. This chapter provides a comprehensive overview of the application of DTI tractography combined with neuro-navigation in glioma resections within critical functional areas. The foundational principles of DTI are explored, with a focus on its role in reconstructing fiber tracts and key neural pathways. Current clinical research is reviewed, highlighting its contribution to achieving higher rates of gross total resection (GTR) while minimizing postoperative complications. Additionally, the limitations of DTI tractography, such as image distortion caused by peritumoral edema or tumor infiltration, are examined along with technical strategies designed to address these challenges.
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Y. Shan, Frank, Dongxia Feng, Yilu Zhang, Karming Fung, Jennifer H. Murillo, and Jason H. Huang. "Diagnosis and Grading of Meningiomas." In Meningioma - The Essentials from Bench to Bedside [Working Title]. IntechOpen, 2024. http://dx.doi.org/10.5772/intechopen.1004927.

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Meningiomas are the most common primary brain tumors in adults. They are slow growing, mostly benign tumors affecting primarily older people. Meningiomas comprise a family of neoplasms that are most likely derived from the meningothelial cells of the arachnoid cap cell. Current diagnosis of meningioma has been facilitated by MRI scans, and most patients with meningiomas have good prognosis without affecting the quality of life after successful treatment, like gross total resection (GTR). This chapter will briefly review the molecular basis, clinical diagnosis and grading of meningiomas and the treatment options.
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"The Role of Gross Total Resection in the Management of Pineal Region Tumors." In Controversies in Neuro-Oncology, edited by Alfredo Quiñones-Hinojosa and Shaan M. Raza. Georg Thieme Verlag, 2014. http://dx.doi.org/10.1055/b-0034-91022.

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Conference papers on the topic "Gross-total resection"

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Schneider, Julia, Amrit Chiluwal, Orseola Arapi, Kevin Kwan, and Amir Dehdashti. "Near-Total versus Gross-Total Resection of Large Vestibular Schwannomas: Facial Nerve Outcome." In 29th Annual Meeting North American Skull Base Society. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1679585.

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Bhatnagar, Surg C., Surg Cmde Mathai, and Surg Vibhakar. "An analysis of intraoperative ultrasound-guided gross total resection in glioblastoma multiforme." In 17th Annual Conference of Indian Society of Neuroanaesthesiology and Critical Care. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0038-1667549.

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Silveira, Emily Santos da, Guilherme Requião Radel Neto, Julia Souza e. Costa, and César de Carvalho Garcia. "Resection of low-grade temporal gliomas and the improvement of convulsive seizures." In XIV Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s1.479.

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Introduction: Epilepsy is a neurological disorder marked by recurring seizures, and secondary epilepsy refers to seizures that are generated by an underlying medical condition or injury. Low-grade temporal gliomas (LGTGs) frequently have epileptogenic potential, causing seizures. Tumor resection is often the preferred treatment when timing and compatibility with the patient and tumor attributes are determined. Objectives: To discuss the main factors in the medical literature relevant to the improvement of seizures by resection of LGTGs and their surgical features. Methods: A literature review was performed within the PubMed database, using the keywords “low-grade gliomas”, “low-grade tumors”, “resection”, “seizures” and “epilepsy”. Publications from 2010 to 2023 were included. Results: Studies point out that gross full extension resection of LGTGs to achieve seizure freedom results in superior positive outcomes when compared to partial resection for Engel class I patients. Of the patients who had a partial resection, memory deficits were frequent. In addition, recurring epilepsy related to lowgrade tumors and the time span of epilepsy were reported to be higher in children than in adults. Postoperative outcomes of patients with mesial temporal lobe lesions outperformed those with lateral temporal tumors. The addition of hypocampectomy and/or corticectomy of the anterior temporal lobe further improved the seizure freedom rate when compared to gross total lesionectomy. Conclusion: Gross total resection of LGTGs provides a more favorable outcome than partial resection. After surgery, the seizure freedom rate is high (> 70%), and resection type is a significant predictor of seizure recurrence. Subtotal resection has a lower seizure-free rate compared to total lesionectomy, with additional benefits seen from hypocampectomy and/or corticectomy of the anterior temporal lobe. Tumor pathology or laterality did not significantly predict seizure freedom.
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Abdallah, Hussein M., Zachary C. Gersey, Zane Gray, et al. "Endoscopic Endonasal Resection of Nonfunctional Pituitary Adenomas: Comprehensive Clinical Outcomes and the Radiographic Findings Associated with Gross Total Resection." In 31st Annual Meeting North American Skull Base Society. Georg Thieme Verlag KG, 2022. http://dx.doi.org/10.1055/s-0042-1743949.

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Lu, Victor, Avital Perry, Christopher Graffeo, Krishnan Ravindran, and Jamie Van Gompel. "Recurrence of Rathke’s Cleft Cysts Based on Gross Total Resection of Cyst Wall: A Meta-analysis." In 30th Annual Meeting North American Skull Base Society. Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0040-1702442.

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Barbero, J. Manuel Revuelta, Edoardo Porto, Tomas Garzon Muvdi, et al. "Microsurgical Gross-Total Resection of an Intracanalicular-Cisternal (KOOS-II) Vestibular Schwannoma via a Retrosigmoid Approach." In 32nd Annual Meeting North American Skull Base Society. Georg Thieme Verlag KG, 2023. http://dx.doi.org/10.1055/s-0043-1762515.

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Strickland, Ben A., Shane Shahrestani, Gabriel Zada, and Steven Giannotta. "Gross Total Resection of the Petroclival Meningioma in the Era of Radiosurgery: A Multi-decade Institutional Experience." In Special Virtual Symposium of the North American Skull Base Society. Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/s-0041-1725338.

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Mekonnen, Mahlet, Ammad A. Baig, Maya Harary, Gabrielle Hovis, Elad Levy, and Isaac Yang. "A Greater Degree of Tumor Softness, Decrease in Tumor Blush, and Gross Total Resection Is Achieved at 24 Hours or Less between Meningioma Preoperative Embolization to Tumor Resection." In 33rd Annual Meeting North American Skull Base Society. Georg Thieme Verlag KG, 2024. http://dx.doi.org/10.1055/s-0044-1779895.

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Mooney, Michael, Christina Sarris, James Zhou, et al. "Proposal and Validation of a Simple Grading Scale (TRANSSPHER Grade) for Predicting Gross-Total Resection of Nonfunctioning Pituitary Macroadenomas after Transsphenoidal Surgery." In 29th Annual Meeting North American Skull Base Society. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1679529.

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Momin, Arbaz, Pranay Soni, Jenny Shao, et al. "To Radiate Upfront or at Initial Recurrence after Gross Total Resection of Newly Diagnosed WHO II Meningiomas? A Propensity Score–Adjusted Analysis." In Special Virtual Symposium of the North American Skull Base Society. Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/s-0041-1722903.

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Reports on the topic "Gross-total resection"

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Gong, Xuan, Zhou Chen, Kui Yang, et al. Endoscopic Transsphenoidal Surgery for Infra-Diaphragmatic Craniopharyngiomas: Impact of Diaphragm Sellae Competence on Hypothalamic Injury. International Journal of Surgery, 2024. http://dx.doi.org/10.60122/j.ijs.2024.20.03.

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Objective: Investigate the impact of diaphragm sellae competence on surgical outcomes and risk factors for postoperative hypothalamic injury (HI) in patients undergoing endoscopic transsphenoidal surgery (ETS) for infra-diaphragmatic craniopharyngiomas (ICs). Methods: A retrospective analysis of 54 consecutive patients (2016-2023) with ICs treated by ETS was conducted. All tumors originated from the sellar region inferior to the diaphragm sellae and were classified into two subtypes in terms of diaphragm sellae competence: IC with competent diaphragm sellae (IC-CDS) and IC with incompetent diaphragm sellae (IC-IDS). Clinical features, intraoperative findings, and follow-up data were compared between subtypes. Postoperative HI was assessed using a magnetic resonance imaging-based scoring system. Results: Fifty-four patients (29 males, 25 females) were included in this study, with 12 (22.2%) under 18 years old. Overall, 35 cases were IC-CDS, while 19 were IC-IDS. Compared with IC-CDS, patients with IC-IDS tended to have hormone hypofunction before surgery (p = 0.03). Tumor volume in IC-IDS group (9.0 ± 8.6 cm3) was also higher than that in IC-CDS group (3.3 ±3.4 cm, p = 0.011). Thirty-seven patients underwent standard endoscopic transsphenoidal approach (SEA) and 17 underwent an extended endoscopic transsphenoidal approach (EEA). Gross total resection (GTR) was achieved in 50 cases (92.6%). Postoperative CSF leak was observed in four patients (7.4%). Permanent diabetes insipidus (DI) occurred in 13 patients (27.7%), six in IC-CDS and seven in IC-IDS. Postoperative HI occurred in 38.9% of patients. Univariate analysis revealed that large tumor size (p = 0.014), prior hypopituitarism (p = 0.048) and IC-IDS (p < 0.001) were significantly associated with postoperative HI. Multivariate analysis revealed that IC- IDS was the sole predictor of postoperative HI. Conclusion: To our knowledge, this is the largest case series in the literature to describe IC resected by endoscopic surgery in a single institution. Classification based on diaphragm sellae competence highlights distinct clinical features and surgical outcomes between IC-CDS and IC-IDS subtypes. Notably, IC-IDS is an independent risk factor for postoperative HI. Preoperative identification of subtype can guide surgical strategy and potentially minimize complications.
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