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Dissertations / Theses on the topic 'Group b streptococcus agalactiae'

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Published: 3 June 2025
Last updated: 31 July 2025

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1

Hull, James Richard. "The interactions of group B Streptococci with human fibronectin /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/9917.

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2

Siqueira, Fabio [UNESP]. "Colonização de pacientes grávidas por Streptococcus agalactiae em Taguatinga, Distrito Federal, Brasil." Universidade Estadual Paulista (UNESP), 2017. http://hdl.handle.net/11449/148701.

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3

Siqueira, Fabio. "Colonização de pacientes grávidas por Streptococcus agalactiae em Taguatinga, Distrito Federal, Brasil." Botucatu, 2017. http://hdl.handle.net/11449/148701.

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Orientador: Adriano Dias<br>Resumo: Objetivo: verificar a prevalência do estreptococo do grupo B em gestantes de Taguatinga, Distrito Federal, Brasil. Desenho: Estudo transversal. Local: Taguatinga (Região metropolitana de Brasília), Distrito Federal, Brasil. Introdução: o estreptococo do Grupo B é responsável por infecções graves em neonatos, resultante da transmissão vertical por gestantes colonizadas nas regiões anal, perineal ou vaginal. A identificação das pacientes colonizadas e uso de profilaxia intraparto podem reduzir o risco de infeção neonatal Métodos: Estudo transversal em paciente
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4

Kong, Fanrong. "Integrated study of group B streptococcus and human ureaplasmas : the paradigm shifts." Thesis, The University of Sydney, 2004. http://hdl.handle.net/2123/592.

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Group B streptococcus (GBS, S. agalactiae) and human ureaplasmas (U. parvumand U. urealyticum) are two clinically and phylogenetically related, potential perinatal pathogens. Their relationships between genotypes and pathogenesis of GBS and ureaplasma infection were still not well understood, one of the reason is that both of them are still short of a very practical genotyping system. In the study, to solve the above problem we developed genotyping systems for the organisms (the second section). For human ureaplasmas, based on four genes/gene clusters (rRNAgene clusters, the elongation factor
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5

Kong, Fanrong. "Integrated study of group B streptococcus and human ureaplasmas � the paradigm shifts." University of Sydney. Medicine, 2004. http://hdl.handle.net/2123/592.

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Group B streptococcus (GBS, S. agalactiae) and human ureaplasmas (U. parvumand U. urealyticum) are two clinically and phylogenetically related, potential perinatal pathogens. Their relationships between genotypes and pathogenesis of GBS and ureaplasma infection were still not well understood, one of the reason is that both of them are still short of a very practical genotyping system. In the study, to solve the above problem we developed genotyping systems for the organisms (the second section). For human ureaplasmas, based on four genes/gene clusters (rRNAgene clusters, the elongation factor
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6

Baudet, Géraldine. "Détermination des sérotypes et des profils estérasiques de souches de streptocoques du groupe B isolées chez le nouveau-né et relation avec la virulence." Paris 5, 1995. http://www.theses.fr/1995PA05P193.

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7

Altrichter, Loan Catherine. "Ostéomyélites et ostéoarthrites à streptocoque béta-hémolytique du groupe B ("Streptococcus agalactiae") /." Genève : [s.n.], 2004. http://www.unige.ch/cyberdocuments/theses2004/AltrichterL/these.pdf.

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8

Hays, Constantin. "Influence de l'imprégnation hormonale périnatale sur la virulence du Streptocoque du groupe B Perinatal hormonal concentrations favor CC17 group B Streptococcus hypervirulence and intestinal translocation through M cells." Thesis, Sorbonne Paris Cité, 2018. https://wo.app.u-paris.fr/cgi-bin/WebObjects/TheseWeb.woa/wa/show?t=2183&f=15494.

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Streptococcus agalactiae (streptocoque du groupe B, SGB) représente la première cause d'infections néonatales bactériennes invasives pour lesquelles on définit deux syndromes, un syndrome précoce (SP, 1ère semaine de vie) et un syndrome tardif (ST, 7 à 89 jours après la naissance). Le SP se manifeste par une pneumonie associée ou non à une bactériémie et résulte de l'inhalation par le nouveau-né de sécrétions vaginales ou de liquide amniotique contaminés par le SGB. Le ST se déclare par une septicémie dont la porte d'entrée serait le tractus gastro-intestinal et est caractérisé par un fort tau
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9

Engelbrecht, Fredrika. "The antimicrobial susceptibility and gene-based resistance of Streptococcus Agalactiae (group B Streptococcus) in pregnant women in Windhoek (Khomas region), Namibia." Thesis, Cape Peninsula University of Technology, 2015. http://hdl.handle.net/20.500.11838/2238.

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Thesis (MTech (Biomedical Sciences))--Cape Peninsula University of Technology, 2015.<br>BACKGROUND AND OBJECTIVES: Group B Streptococci (GBS) can asymptomatically colonise the vagina and rectum of women. Studies have shown that this bacterium is the leading cause of septicemia, meningitis and pneumonia in neonates. In Namibia no known studies have investigated GBS colonisation and the antibiotic resistance profile of GBS isolates in pregnant women. This study accessed the GBS colonisation rate amongst the pregnant women who attended the Windhoek Central Hospital Antenatal Clinic (Khomas region
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10

Bouquinet, Émilie Cohen Robert. "Méningites à streptocoque du groupe B de l'enfant." Créteil : Université de Paris-Val-de-Marne, 2008. http://doxa.scd.univ-paris12.fr:80/theses/th0483135.pdf.

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11

Bouillevaux, Emilie. "Efficience du mode de prélèvement vaginal dans le cadre du dépistage systématique du Streptocoque du groupe B étude de 1353 prélèvements /." Nancy : Université Henri-Poincaré, 2009. http://www.scd.uhp-nancy.fr/docnum/SCDMED_MESF_2009_BOUILLEVAUX_EMILIE.pdf.

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12

Bouhafs, Rabea K. L. "Direct and phagocyte-mediated lipid peroxidation of lung surfactant by group B streptococci and other bacteria : protective effects of antioxidants /." Stockholm, 2002.

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13

Beauruelle, Clémence. "Locus CRISPR de Streptococcus agalactiae : marqueur génétique de la phylogénie de l'espèce et de l'évolution récente des isolats." Electronic Thesis or Diss., Tours, 2019. http://www.theses.fr/2019TOUR3806.

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Nous avons étudié l’intérêt du locus CRISPR1 (associé au système CRISPR-Cas de type II-A), comme marqueur épidémiologique pour le typage et l’analyse phylogénétique des souches de Streptococcus agalactiae, le streptocoque du groupe B (SGB). Par ce travail de thèse, nous avons pu mettre en évidence i) l’activité du système CRISPR-Cas in vivo ainsi que sa faible vitesse d’évolution ii) une conservation des marqueurs ancestraux, permettant d’obtenir des informations sur les lignées phylogénétiques (congruence entre le typage CRISPR et le MLST), iii) un polymorphisme du locus CRISPR1 (notamment de
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14

Tan, Chee Keong. "Development and Application of Escherichia coli and Streptococcus Agalactiae Murine Colonisation Models to Study Bacterial Pathogenesis in the Female Urogenital Tract." Thesis, Griffith University, 2013. http://hdl.handle.net/10072/366082.

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Urinary tract infection (UTI) is one of the most common infections and costs millions of dollar each year to the health care industry. Escherichia coli is the causative agent responsible for over 80% of UTIs. However, other pathogens such as Group B streptococcus (GBS), a Grampositive bacterium, also cause UTI. In addition, GBS is an important commensal microbe in the female genital tract. Researchers have used various murine models to study mechanisms of disease pathogenesis for UTI and microbe colonisation of the genital tract. However, there is a lack of understanding of the pathogenic mech
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15

Nomura, Marcelo Luis. "Colonização materna e neonatal por estreptococo do grupo B em gestantes com trabalho de parto prematuro e/ou ruptura prematura pré-termo de membranas." [s.n.], 2004. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313319.

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Orientador: Renato Passini Junior<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-04T01:25:35Z (GMT). No. of bitstreams: 1 Nomura_MarceloLuis_D.pdf: 838174 bytes, checksum: a795b39457b62a18ecb17c4609ece12d (MD5) Previous issue date: 2004<br>Resumo: Objetivos: Identificar a taxa de prevalência e fatores de risco de colonização materna por estreptococo do grupo B (EGB) em gestantes com trabalho de parto prematuro (TPP) e/ou ruptura prematura pré-termo de membranas (RPM). Métodos: Foram colhidos dois swabs anais e vag
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16

Ventura, Maria Sidneuma Melo. "ColonizaÃÃo em gestantes e infecÃÃo neonatal por Streptococcus do Grupo B." Universidade Federal do CearÃ, 2009. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=4489.

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LabPasteur<br>Objetivos deste estudo: identificar a prevalÃncia e os fatores de risco da colonizaÃÃo materna e infecÃÃo neonatal por streptococcus do grupo B (SGB), em mulheres com trabalho de parto prematuro (TPP) e/ou ruptura prematura de membranas (RPM); medir e comparar taxas de colonizaÃÃo vaginal e anorretal por SGB, comparar taxas de detecÃÃo do SGB em meio de cultura seletivo (Todd-Hewitt) e nÃo seletivo (Stuart) e com cultivo em Ãgar-sangue e Ãgar- CPS. Estudo transversal de 112 mulheres e 220 recÃm-nascidos realizou-se na Maternidade Escola Assis Chateaubriand da Universidade federal
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17

Jorge, Luciana Souza. "Prevalência de colonização por Streptococcus do grupo B entre gestantes ou parturientes atendidas no Hospital de Base de São José do Rio Preto/SP." Faculdade de Medicina de São José do Rio Preto, 2005. http://hdl.handle.net/tede/263.

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Submitted by Natalia Vieira (natalia.vieira@famerp.br) on 2016-05-30T21:52:31Z No. of bitstreams: 1 lucianasouzajorge_dissert.pdf: 1193713 bytes, checksum: 87fe8f7c70497cf298249a806a3219b4 (MD5)<br>Made available in DSpace on 2016-05-30T21:52:31Z (GMT). No. of bitstreams: 1 lucianasouzajorge_dissert.pdf: 1193713 bytes, checksum: 87fe8f7c70497cf298249a806a3219b4 (MD5) Previous issue date: 2005-07-04<br>Since the 1970´s Group B Streptococcus (GBS) or Streptococcus agalactiae has been considered the leading cause of early-onset neonatal disease. Even after the adoption of strategies for i
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18

Yang, Qian. "Proteomic investigation of the group B streptococcus." Thesis, Northumbria University, 2011. http://nrl.northumbria.ac.uk/2119/.

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The Group B Streptococcus (GBS) is a Gram-positive opportunistic pathogen which is a leading cause of neonatal disease globally. In 2000-2001, the general incidence of neonatal GBS infection was 0.72 per 1000 live births in U.K. and the mortality rate is about 10%, because of which neonatal GBS disease is a significant burden on society. GBS is part of the commensal flora, colonising the vagina and gastrointestinal tract of women. Vertical transmission is the main cause of early onset GBS disease. During the process of GBS neonatal disease, GBS must be able to survive in several very different
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19

Luan, Shi-Lu. "Molecular epidemiology of Streptococcus agalactiae : mobile elements as genetic markers /." Doctoral thesis, Umeå : Umeå University, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-877.

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20

Jones, Nicola. "A molecular epidemiological investigation of group B streptococcus." Thesis, Open University, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.402623.

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A multilocus sequence typing (MLST) system for group B streptococcus (GBS) has been developed and validated on a global collection of human GBS strains isolated from carriage and invasive disease. A carriage study was performed, over a 3-year period, to establish the rate of carriage ofGBS in pregnant women in Oxford, UK. Invasive isolates were collected, prospectively and retrospectively over a similar time period. Twenty-one percent of women studied were asymptomatic carriers of GBS. The incidence of invasive GBS was 0.9/1000 live births in neonates and 6.11100,000 population >60 years. The
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21

GIUSSANI, STEFANIA. "Mechanisms of Complement evasion in Group B Streptococcus." Doctoral thesis, Università degli studi di Pavia, 2019. http://hdl.handle.net/11571/1248526.

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GIUSSANI, STEFANIA. "Mechanisms of Complement evasion in Group B Streptococcus." Doctoral thesis, Università degli studi di Pavia, 2019. http://hdl.handle.net/11571/1263953.

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GIUSSANI, STEFANIA. "Mechanisms of Complement evasion in Group B Streptococcus." Doctoral thesis, Università degli studi di Pavia, 2019. http://hdl.handle.net/11571/1264013.

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GIUSSANI, STEFANIA. "Mechanisms of Complement evasion in Group B Streptococcus." Doctoral thesis, Università degli studi di Pavia, 2019. http://hdl.handle.net/11571/1263915.

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GIUSSANI, STEFANIA. "Mechanisms of Complement evasion in Group B Streptococcus." Doctoral thesis, Università degli studi di Pavia, 2019. http://hdl.handle.net/11571/1264035.

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GIUSSANI, STEFANIA. "Mechanisms of Complement evasion in Group B Streptococcus." Doctoral thesis, Università degli studi di Pavia, 2019. http://hdl.handle.net/11571/1248546.

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GIUSSANI, STEFANIA. "Mechanisms of Complement evasion in Group B Streptococcus." Doctoral thesis, Università degli studi di Pavia, 2019. http://hdl.handle.net/11571/1263975.

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GIUSSANI, STEFANIA. "Mechanisms of Complement evasion in Group B Streptococcus." Doctoral thesis, Università degli studi di Pavia, 2019. http://hdl.handle.net/11571/1263893.

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GIUSSANI, STEFANIA. "Mechanisms of Complement evasion in Group B Streptococcus." Doctoral thesis, Università degli studi di Pavia, 2019. http://hdl.handle.net/11571/1265353.

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GIUSSANI, STEFANIA. "Mechanisms of Complement evasion in Group B Streptococcus." Doctoral thesis, Università degli studi di Pavia, 2019. http://hdl.handle.net/11571/1248470.

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GIUSSANI, STEFANIA. "Mechanisms of Complement evasion in Group B Streptococcus." Doctoral thesis, Università degli studi di Pavia, 2019. http://hdl.handle.net/11571/1265253.

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32

GIUSSANI, STEFANIA. "Mechanisms of Complement evasion in Group B Streptococcus." Doctoral thesis, Università degli studi di Pavia, 2019. http://hdl.handle.net/11571/1266678.

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33

GIUSSANI, STEFANIA. "Mechanisms of Complement evasion in Group B Streptococcus." Doctoral thesis, Università degli studi di Pavia, 2019. http://hdl.handle.net/11571/1265273.

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34

Ventura, Maria Sidneuma Melo. "Colonização em gestantes e infecção neonatal por Streptococcus do grupo B." reponame:Repositório Institucional da UFC, 2009. http://www.repositorio.ufc.br/handle/riufc/1322.

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VENTURA, Maria Sidneuma Melo. Colonização em gestantes e infecção neonatal por Streptococcus do grupo B. 2009. 69 f. Dissertação (Mestrado em Saúde Pública) - Universidade Federal do Ceará, Fortaleza, 2009.<br>Submitted by denise santos (denise.santos@ufc.br) on 2011-11-08T13:21:42Z No. of bitstreams: 1 2009_dis_msmventura.pdf: 104830 bytes, checksum: 884e55cddb6fb4624b7bfa5f83de382d (MD5)<br>Approved for entry into archive by Eliene Nascimento(elienegvn@hotmail.com) on 2011-12-05T12:23:26Z (GMT) No. of bitstreams: 1 2009_dis_msmventura.pdf: 104830 bytes, checksum: 884e55cddb6fb4624b7bfa5f83d
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Pereira, Camila Serva. "Aderência, invasão e persistência intracelular de estreptococos do grupo B em células epiteliais respiratórias A549." Universidade do Estado do Rio de Janeiro, 2010. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2392.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>Estreptococos do grupo B (EGB) comumente colonizam adultos saudáveis, sem sintomas, mas sob certas circunstâncias possui a capacidade de invadir tecidos do hospedeiro, evadir da detecção imunológica e causar doenças invasivas graves. Por conseguinte, os EGB continuam sendo uma das principais causas de mortalidade neonatal, pneumonia, sepse e meningite. Contudo, a patogênese desta infecção ainda está pouco elucidada. O sorotipo V é freqüentemente associado à doença invasiva em mulheres adultas não gestantes e o segundo mais preva
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Yildirim, Ali Önder. "Phäno- und Genotypisierung von Streptokokken der serologischen Gruppe B (Streptococcus agalactiae), isoliert von verschiedenen Tierarten." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=964751763.

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37

Rego, Sara. "Molecular basis of group B streptococcus pathogenesis and colonisation." Thesis, University of Bristol, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.702432.

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Streptococcus agalactiae (Group B Streptococcus, GBS) is a cause of life-threatening infections in neonates and in the elderly. Clinical presentations of GBS disease include sepsis, pneumonia and meningitis. GBS normally resides as a commensal microorganism of the female genitourinary tract, where it can be vertically transmitted to the foetus/neonate in utero or during parturition. The oropharynx also represents an important point of entry for GBS in both neonates and adults. GBS is thus able to adhere to a variety of host tissues, including epithelia of the vagina, lung or meninges. These in
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Ng, Sherrianne Qin Yin. "Preterm infant IFN-Beta responses to Group B streptococcus." Thesis, Ng, Sherrianne Qin Yin (2013) Preterm infant IFN-Beta responses to Group B streptococcus. Honours thesis, Murdoch University, 2013. https://researchrepository.murdoch.edu.au/id/eprint/17002/.

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Group B streptococcus (GBS) is the leading cause of early onset sepsis in preterm infants. The production of IFN-Beta shown to be critical for host defense against GBS in murine studies. The release of GBS-DNA into the cytosol of mouse macrophages was found to induce IFN-Beta monocytes and macrophages produce IFN-Beta GBS-DNA plays in this process. This study optimised a whole blood assay to determine if human monocyte subsets are capable of inducing IFN-Beta as cytosolic GBS-DNA. The main findings were that (A) all adult blood monocyte subsets were capable of producing IFN-Beta cytosolic GBS-
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39

Costa, Adriana Lima dos Reis. "COLONIZAÇÃO PELO ESTREPTOCOCO DO GRUPO B EM GESTANTES DURANTE O TRABALHO DE PARTO EM UMA MATERNIDADE DE SÃO LUÍS, MARANHÃO." Universidade Federal do Maranhão, 2008. http://tedebc.ufma.br:8080/jspui/handle/tede/1111.

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Made available in DSpace on 2016-08-19T18:15:56Z (GMT). No. of bitstreams: 1 Adriana Lima dos Reis Costa.pdf: 384922 bytes, checksum: cadf2a371d3a4b2bf8adfc2bd54febf6 (MD5) Previous issue date: 2008-10-02<br>Objective: To study the colonization with group B streptococcus (GBS) in pregnant women near or in time for delivery. Methods: Vaginal and rectal cultures of 201 pregnant women were collected in the Marly Sarney Maternity in São Luís Maranhão, Brazil. The samples had been inoculated in Todd- Hewith selective media and then subcultured in plates of Agar-blood. The CAMP test was used for
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Brasil, Tatiana Braga. "Transferência transplacentária de anticorpos anti-Streptococcus B nos recém-nascidos de termo e pré-termo." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-25082008-152728/.

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O Streptococcus do Grupo B (EGB) é um dos principais agentes de infecção no período neonatal, sendo responsável por altos índices de morbimortalidade materno-fetal. Este estudo tem por objetivo avaliar a passagem transplacentária de anticorpos anti-Streptococcus B e imunoglobulina G em recém-nascidos de termo e pré-termo, bem como comparar seus níveis séricos. Foi realizado estudo transversal incluindo 44 recém-nascidos (18 pré-termo e 26 de termo) do Berçário Anexo à Maternidade do Hospital das Clínicas da FMUSP no período de dezembro de 2006 a julho de 2007. Após consentimento esclarecido, f
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41

Lazzarin, Maddalena <1986&gt. "Structural and functional characterization of Group B Streptococcus pilus 2b." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amsdottorato.unibo.it/6815/1/lazzarin_maddalena_tesi.pdf.

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Group B Streptococcus (GBS) is a Gram-positive human pathogen representing one of the most common causes of life-threatening bacterial infections such as sepsis and meningitis in neonates. Covalently polymerized pilus-like structures have been discovered in GBS as important virulence factors as well as vaccine candidates. Pili are protein polymers forming long and thin filamentous structures protruding from bacterial cells, mediating adhesion and colonization to host cells. Gram-positive bacteria, including GBS, build pili on their cell surface via a class C sortase-catalyzed transpeptidation
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Lazzarin, Maddalena <1986&gt. "Structural and functional characterization of Group B Streptococcus pilus 2b." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amsdottorato.unibo.it/6815/.

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Group B Streptococcus (GBS) is a Gram-positive human pathogen representing one of the most common causes of life-threatening bacterial infections such as sepsis and meningitis in neonates. Covalently polymerized pilus-like structures have been discovered in GBS as important virulence factors as well as vaccine candidates. Pili are protein polymers forming long and thin filamentous structures protruding from bacterial cells, mediating adhesion and colonization to host cells. Gram-positive bacteria, including GBS, build pili on their cell surface via a class C sortase-catalyzed transpeptidation
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43

Rodrigues, Monica Meira Leite [UNIFESP]. "A associação dos Streptococcus agalactiae com inflamação vaginal em mulheres atendidas nos laboratórios públicos de Maceió." Universidade Federal de São Paulo (UNIFESP), 2009. http://repositorio.unifesp.br/handle/11600/8806.

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Made available in DSpace on 2015-07-22T20:49:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-06-30<br>Introdução - Os Streptococcus agalactiae são bactérias consideradas parte da microbiota da vagina, das vias aéreas superiores e do trato intestinal, porém sua importância como patógeno humano vem crescendo no decorrer dos anos. Quando presente na vagina podem trazer sérias consequências para a mulher, podendo estar associados à infertilidade, aumentar o risco de ruptura prévia de membrana, levar a corioaminionite, endometrite, etc. e, a partir da colonização vaginal da mãe, pode t
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44

Smith, Jennifer Marie. "Characterization of host-bacteria interactions contributing to group B streptococcus colonization." Huntington, WV : [Marshall University Libraries], 2002. http://www.marshall.edu/etd/descript.asp?ref=64.

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45

Seedat, Farah. "Universal antenatal screening for group B streptococcus colonisation in the UK." Thesis, University of Warwick, 2017. http://wrap.warwick.ac.uk/103062/.

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Background: Group B Streptococcus (GBS) is the leading cause of neonatal sepsis and meningitis. Currently, the UK recommends against universal antenatal screening to prevent early-onset GBS disease (EOGBS, < 7 days). Key gaps around GBS natural history, harms from screening and a lack of high-quality data to prove screening effectiveness make it difficult to ensure the benefits of GBS screening outweigh the harms. There is also a wider gap on policy-making processes for screening. The overall aim of this thesis is to address these gaps and examine whether the UK should introduce universal GBS
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46

Varghese, Brian R. "Characterising the Antimicrobial Effect of Zinc Intoxication in Group B Streptococcus." Thesis, Griffith University, 2023. http://hdl.handle.net/10072/421271.

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Group B Streptococcus (GBS) is a Gram-positive bacteria known for causing a wide range of illnesses in neonates, pregnant woman, elderly, and immunocompromised people. Intrapartum antibiotic prophylaxis is the current prevention measure for pregnant women used worldwide and has been highly successful thus far. However, it is a dangerous long-term approach with the rising antimicrobial resistance crisis. Vaccine development has been ongoing for several decades and remains a key area of study for GBS researchers worldwide. Finding an effective vaccine target candidate that can be packaged in a s
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47

Cozzi, Roberta <1981&gt. "Structural and functional characterization of Group B Streptococcus class C sortases." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3522/1/Cozzi_Roberta_tesi.pdf.

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In Group B Streptococcus (GBS) three structurally distinct types of pili have been discovered as potential virulence factors and vaccine candidates. The pilus-forming proteins are assembled into high-molecular weight polymers via a transpeptidation mechanism mediated by specific class C sortases. Using a multidisciplinary approach including bioinformatics, structural and biochemical studies and in vivo mutagenesis we performed a broad characterization of GBS sortase C. The high resolution X-ray structure of the enzymes revealed that the active site, located into the β-barrel core of the enzym
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48

Cozzi, Roberta <1981&gt. "Structural and functional characterization of Group B Streptococcus class C sortases." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3522/.

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Abstract:
In Group B Streptococcus (GBS) three structurally distinct types of pili have been discovered as potential virulence factors and vaccine candidates. The pilus-forming proteins are assembled into high-molecular weight polymers via a transpeptidation mechanism mediated by specific class C sortases. Using a multidisciplinary approach including bioinformatics, structural and biochemical studies and in vivo mutagenesis we performed a broad characterization of GBS sortase C. The high resolution X-ray structure of the enzymes revealed that the active site, located into the β-barrel core of the enzym
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49

Prince, Darren William. "The Co-Transcriptional Response of Intracellular Group B Streptococcus (GBS) and Monocytes." Thesis, Griffith University, 2019. http://hdl.handle.net/10072/389087.

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Group B Streptococcus (GBS) is a species of gram positive bacteria representing a significant human pathogen; namely, as the most prolific cause of neonatal disease and mortality globally, but also increasingly reported in adult disease (especially among the elderly and those with compromised immune systems). The first chapter of this thesis reviews the extensive literature covering GBS; with a focus on classification and disease. Selected virulence factors are also discussed. In chapter 2, eight strains of GBS were selected for whole genome sequencing by Third Generation, Pacific Biosystems (
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50

Zerbini, Francesca <1982&gt. "Polymerizing activity and regulation of group B Streptococcus pilus 2a sortase C1." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6480/1/Zerbini_Francesca_tesi.pdf.

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Group B Streptococcus [GBS; Streptococcus agalactiae] is the leading cause of life-threatening diseases in newborn and is also becoming a common cause of invasive diseases in non-pregnant, elderly and immune-compromised adults. Pili, long filamentous fibers protruding from the bacterial surface, have been discovered in GBS, as important virulence factors and vaccine candidates. Gram-positive bacteria build pili on their cell surface via a class C sortase-catalyzed transpeptidation mechanism from pilin protein substrates. Despite the availability of several crystal structures, pilus-related C s
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