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Journal articles on the topic 'Group LDA'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 September 2023

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1

Boedeker, Peter, and Nathan T. Kearns. "Linear Discriminant Analysis for Prediction of Group Membership: A User-Friendly Primer." Advances in Methods and Practices in Psychological Science 2, no. 3 (2019): 250–63. http://dx.doi.org/10.1177/2515245919849378.

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In psychology, researchers are often interested in the predictive classification of individuals. Various models exist for such a purpose, but which model is considered a best practice is conditional on attributes of the data. Under certain conditions, linear discriminant analysis (LDA) has been shown to perform better than other predictive methods, such as logistic regression, multinomial logistic regression, random forests, support-vector machines, and the K-nearest neighbor algorithm. The purpose of this Tutorial is to provide researchers who already have a basic level of statistical trainin

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Akther, Ummay Sufia, Jakaria Kabir, Liaquat Ali, and Nazia Haque Setu. "Low Dose Aspirin for Primary Prevention of Adverse Pregnancy Outcome." Annals of International Medical and Dental Research 9, no. 2 (2023): 68–75. http://dx.doi.org/10.53339/aimdr.2023.9.14.

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Background: Pregnancy is associated with various complications such as pre-eclampsia, SGA, preterm birth etc. Low dose aspirin is a possible medication to minimize these adverse outcomes. The aim of this study was to evaluate the use of low dose aspirin for primary prevention of adverse pregnancy outcome. Material Methods: This cross-sectional study was conducted in department of Gynaecology, North Bengal Medical College Hospital, Mirjapur Bkash Hospital, Mirjapur, Tangail, Bangladesh, during the period from June 2021 to August 2022. Total 200 pregnant women were included in this study. Result

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Sonkusale, Lakshmi. "Exploring the Applicability of Topic Modeling in SARS-CoV-2 Literature and Impact on Agriculture." Indian Research Journal of Extension Education 22, no. 4 (2022): 48–56. http://dx.doi.org/10.54986/irjee/2022/oct_dec/48-56.

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For the last two years, countries around the globe have been suff ering and severely aff ected by the Covid-19 pandemic due to the novel coronavirus. Researchers from various disciplines are conducting research and publishing number of articles related to this virus and its eff ects. Furthermore, articles related to Covid-19 are being continuously published in the form of research papers, popular articles, blogs, surveys, short stories etc. These possess useful information and this information can be processed to infer important knowledge by applying text mining techniques. The Latent Dirichle

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Brodzki, Piotr, Adam Brodzki, Łukasz Kurek, Jan Marczuk, and Marcin R. Tatara. "Reproductive System Condition in Dairy Cows with Left-Sided Displacement of the Abomasums." Annals of Animal Science 15, no. 2 (2015): 359–71. http://dx.doi.org/10.1515/aoas-2015-0009.

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Abstract The aim of the study was to evaluate selected parameters representing reproductive system conditions in cows suffering from left-sided displacement of the abomasum (LDA). Eighty Holstein- Friesian cows were divided into control (n=40) and LDA (n=40) groups. Haematological and biochemical evaluations were performed in the control group and in cows with LDA before and after surgical treatment. Cytological and ultrasound examinations of the uterus were performed at 21 (baseline), 35 and 63 days after parturition. In the LDA group, significantly decreased concentrations of calcium, magnes

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Tomita, Toshihiko, Sumire Mori, Katsuyuki Tozawa, et al. "Are the Symptoms of an NSAID-Induced Ulcer Truly Milder Than Those of an Ordinary Ulcer?" Gastroenterology Research and Practice 2017 (2017): 1–7. http://dx.doi.org/10.1155/2017/4653250.

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Objective. The percentage of patients with nonsteroidal anti-inflammatory drugs (NSAIDs) and low-dose aspirin- (LDA-) induced ulcers who complain of gastrointestinal symptoms has generally been considered to be low. The aim of this study was to examine and compare the symptoms and quality of life (QOL) at peptic ulcer onset. Methods. This study involved 200 patients who were confirmed by endoscopy to be in the acute stage of gastroduodenal ulcer (A1-H1). Patients completed a self-administered questionnaire (Global Overall Symptom score and SF-8) at ulcer onset, and data were compared between N

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Wang, Zhuo, Songmin Gu, and Xiaowei Xu. "GSLDA: LDA-based group spamming detection in product reviews." Applied Intelligence 48, no. 9 (2018): 3094–107. http://dx.doi.org/10.1007/s10489-018-1142-1.

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Garg, Mohit, and Priya Rangra. "Bibliometric Analysis of Latent Dirichlet Allocation." DESIDOC Journal of Library & Information Technology 42, no. 2 (2022): 105–13. http://dx.doi.org/10.14429/djlit.42.2.17307.

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Latent Dirichlet Allocation (LDA) has emerged as an important algorithm in big data analysis that finds the group of topics in the text data. It posits that each text document consists of a group of topics, and each topic is a mixture of words related to it. With the emergence of a plethora of text data, the LDA has become a popular algorithm for topic modeling among researchers from different domains. Therefore, it is essential to understand the trends of LDA researches. Bibliometric techniques are established methods to study the research progress of a topic. In this study, bibliographic dat

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Yamasaki, M. "AB0271 COMPARISON OF DOSE REDUCTION METHODS BETWEEN RAPIDLY AND GRADUALLY DE-ESCALATION IN RHEUMATOID ARTHRITIS TREATED WITH BARICITINIB OVER 15 MONTHS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1162.1–1162. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2874.

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Background:However tsDMARDs and treatment strategies have improved the outcomes of rheumatoid arthritis (RA), it is unknown who can taper or stop tsDMARDs and strategies for de-escalation.Objectives:We analyze predictors of de-escalation in RA patients treated with baricitinib over 15 months in each group who start baricitinib with 4mg/day and 2mg/day.This study will assess and compare (1) characteristic of patients who achieve remission (REM) or low disease activity (LDA) as who can taper baricitinib and (2) two de-escalation methods, rapidly and gradually de-escalation in patients who respon

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Dibwe, Dya Fita, Saki Oba, Nire Takeishi та ін. "Food-Derived β-Carboline Alkaloids Ameliorate Lipid Droplet Accumulation in Human Hepatocytes". Pharmaceuticals 15, № 5 (2022): 578. http://dx.doi.org/10.3390/ph15050578.

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Lipid droplet accumulation (LDA) in hepatocytes is the initial stage of nonalcoholic fatty liver disease (NAFLD). In the search for natural compounds for the prevention of NAFLD, a series of β-carboline alkaloid derivatives, inspired by flazin and its derivative, newly identified in Crassostrea gigas Thunberg. extracts, were examined for LDA inhibition (LDAI) activity in oleic acid–loaded hepatocytes (HepG2). Eight compounds with a piperidine or pyridine C-ring were chemically synthesized (1–8). Among them, compounds 2 and 4 (flazin) with a carboxy group at C-3 and furfuryl alcohol moiety at C

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Ajrouche, Aya, Candice Estellat, Yann De Rycke, and Florence Tubach. "Trajectories of Adherence to Low-Dose Aspirin Treatment Among the French Population." Journal of Cardiovascular Pharmacology and Therapeutics 25, no. 1 (2019): 37–46. http://dx.doi.org/10.1177/1074248419865287.

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Background: Previous studies have shown that adherence to low-dose aspirin (LDA) is suboptimal. However, these studies were based on an average measure of adherence during follow-up, ignoring its dynamic process over time. We described the trajectories of adherence to LDA treatment among the French population over 3 years of follow-up. Methods: We identified a cohort of 11 793 new LDA users, aged ≥50 years in 2010, by using the French national health-care database. Patients included had at least 3 years of history in the database before study entry to exclude prevalent aspirin users and to ass

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Fleischmann, Roy, Désirée van der Heijde, Andrew S. Koenig, et al. "How much does Disease Activity Score in 28 joints ESR and CRP calculations underestimate disease activity compared with the Simplified Disease Activity Index?" Annals of the Rheumatic Diseases 74, no. 6 (2014): 1132–37. http://dx.doi.org/10.1136/annrheumdis-2013-204920.

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ObjectivesDisease Activity Score in 28 joints calculated with C-reactive protein (DAS28-CRP) is used instead of erythrocyte sedimentation rate (DAS28-ESR) to assess rheumatoid arthritis disease activity; however, values for remission and low disease activity (LDA) for DAS28-CRP have not been validated. American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) guidelines suggest remission should be calculated by Simplified Disease Activity Index (SDAI) rather than DAS28-ESR. We examined values of remission and LDA of DAS28-CRP that correspond to the respective cut-off poin

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Mamak, N., A. K. Devrim, H. Aksit, I. Aytekin, and R. Yıldız. "Levels of antioxidant substances, acute phase response and lipid peroxidation in the left and right abomasum displacement in cows." Polish Journal of Veterinary Sciences 16, no. 4 (2013): 731–33. http://dx.doi.org/10.2478/pjvs-2013-0103.

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AbstractThe aim of the present study was to assess metabolic changes occurring in Holstein cows with left or right abomasal displacement. Total sialic acid (TSA) values of the left abomasal displacement (LDA) group were elevated significantly (p<0.0001) as compared to the controls. In the LDA group, serum ceruloplasmin (CPN) and aspartate transaminase (AST) levels were increased significantly (p<0.0001) as well. Compared to the control group, serum glutathione (GSH) level was decreased significantly in both LDA and right abomasal displacement (RDA) groups (p<0.0001). Among the clinica

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Su, Hang, Suthakar Ganapathy, Zhi-Min Yuan, and Chul S. Ha. "P53-Based Strategy for Protection of Bone Marrow From Y-90 Ibritumomab Tiuxetan." Blood 122, no. 21 (2013): 1839. http://dx.doi.org/10.1182/blood.v122.21.1839.1839.

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Abstract Introduction Though radiolabeled anti-CD20 antibody has expanding roles in the management of B-cell lymphoma, its main drawback has been radiation-induced damage to the bone marrow leading to acute grade 3 and 4 hematological toxicity and potential contribution to the development of myelodysplastic syndrome and secondary leukemia. Arsenic trioxide is currently used to treat acute promyelocytic leukemia and known as a cytotoxic agent. However, we have recently demonstrated that arsenic trioxide can act as a cytoprotective agent at much lower dose. This is due to its ability to temporar

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Shibayama, Keita, Go Kimura, Tatsuro Hayashi, et al. "Meaning and significance of low density area (LDA) of renal cell carcinoma (RCC) on computed tomography (CT)." Journal of Clinical Oncology 36, no. 6_suppl (2018): 628. http://dx.doi.org/10.1200/jco.2018.36.6_suppl.628.

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628 Background: LDA in solid RCC on CT is often interpreted as ‘central necrosis’ in routine clinical practice. However, the details of clinicopathological (CP) features of LDA of RCC on CT and their prognostic significance have not been shown. We retrospectively investigated LDA of RCC to clarify the CP features and prognostic significance. Methods: Of 428 surgically treated patients for RCC between January 2007 and March 2017 at Nippon Medical School hospital, we found 267 cases who had dynamic CT performed before operation. Among them, we selected and analyzed 199 consecutive cases whose tu

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Choi, Byoung Geol, Kyung-Hee Kim, and Seung-Woon Rha. "Safety and efficacy of low-dose aspirin in patients with coronary artery spasm: long-term clinical follow-up." Cardiovascular Prevention and Pharmacotherapy 4, no. 1 (2022): 26–33. http://dx.doi.org/10.36011/cpp.2022.4.e6.

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Background: Aspirin is known to aggravate coronary artery spasm (CAS) regardless of the dose (100–325 mg/day). However, it is unclear whether low-dose aspirin (LDA; 100 mg) has deleterious impacts on the clinical course of CAS patients in the long-term. Thus, we investigated the impact of LDA on the long-term clinical outcomes of CAS patients.Methods: A total of 5,697 consecutive patients without significant coronary artery disease who underwent an acetylcholine provocation test from November 2004 to May 2015 were enrolled. Of these patients, 3,072 CAS patients were enrolled in the study and d

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Bettens, Kim, Gillian de Boer, Tim Bressmann, Laura Bruneel, and Kristiane Van Lierde. "Clinical Application of a New Approach to Identify Oral–Nasal Balance Disorders Based on Nasalance Scores." Cleft Palate-Craniofacial Journal 56, no. 5 (2018): 628–38. http://dx.doi.org/10.1177/1055665618796012.

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Objective: A new approach to classify oral–nasal balance disorders based on instrumental measurements was developed based on linear discriminant analysis (LDA) of nasalance scores of simulated oral–nasal balance disorders by de Boer and Bressmann. The current study aimed to apply the newly developed functions to clinical data to investigate the applicability of this new approach. Design: Retrospective diagnostic accuracy study. Setting: Tertiary university hospital. Participants: Fifty-five Dutch-speaking Flemish children (age 4-12 years) with normal (n = 20), hypernasal (n = 18), hyponasal (n

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Nugroho, Alfarius Eko, Akiyo Hashimoto, Chin-Piow Wong, et al. "Ceramicines M–P from Chisocheton ceramicus: isolation and structure–activity relationship study." Journal of Natural Medicines 72, no. 1 (2017): 64–72. http://dx.doi.org/10.1007/s11418-017-1109-2.

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Abstract Ceramicines are a series of limonoids which were isolated from the bark of Malaysian Chisocheton ceramicus (Meliaceae) and show various biological activities. Ceramicine B, in particular, has been reported to show a strong lipid droplet accumulation (LDA) inhibitory activity on a mouse pre-adipocyte cell line (MC3T3-G2/PA6). With the purpose of discovering compounds with stronger activity than ceramicine B, we further investigated the constituents of C. ceramicus. As a result, from the bark of C. ceramicus four new ceramicines (ceramicines M–P, 1–4) were isolated, and their structures

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Arora, Sandeep, Dharamvir Singh Ahlawat, and Dharambir Singh. "Estimation of Lattice Constants and Band Gaps of Group-III Nitrides using Local and Semi Local Functionals." Oriental Journal of Chemistry 34, no. 4 (2018): 2137–43. http://dx.doi.org/10.13005/ojc/3404055.

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We performed the optimization of lattice constants of Group- III nitrides (InN, AlN, GaN) in wurtzite and Zinc blende structures using various semilocal exchange correlation functional in generalized gradient approximations (GGA) namely PBE, WC, PBEsol in addition to local density approximation (LDA) functional. We used these optimized lattice parameters to predict the band gap values using modified Becke Johnson exchange potential with original and improved parameterization as suggested by David Koller for semiconductors having band gap values below 7eV. Among the different functionals consid

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Coates, Laura C., Philip J. Mease, Dafna D. Gladman, Sandra Navarra, Weibin Bao, and Corine Gaillez. "Secukinumab improves physical function and quality of life and inhibits structural damage in patients with PsA with sustained remission or low disease activity: results from the 2-year phase 3 FUTURE 5 study." RMD Open 9, no. 2 (2023): e002939. http://dx.doi.org/10.1136/rmdopen-2022-002939.

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ObjectiveTo investigate the impact of sustained low disease activity (LDA)/remission (REM) on physical function, quality of life (QoL) and structural outcomes in secukinumab-treated psoriatic arthritis (PsA) patients from the FUTURE 5 study.MethodsFUTURE 5 was a randomised, double-blind, placebo-controlled, parallel-group, phase 3 study in patients with active PsA. Patients were categorised according to LDA (Minimal Disease Activity, MDA/Disease Activity index for Psoriatic Arthritis, DAPSA LDA+REM) or REM (very LDA/DAPSA REM): not achieving LDA/REM, achieving it once or sustained LDA/REM ≥3 t

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Shi, Yuping. "Effect of Atropine Eye Drops Combined with VR-Based Binocular Visual Function Balance Training for Prevention and Control of Juvenile Myopia." Evidence-Based Complementary and Alternative Medicine 2022 (September 13, 2022): 1–6. http://dx.doi.org/10.1155/2022/4159996.

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Purpose. This study mainly analyzes the efficacy of 0.01% atropine eye drops (low-dose atropine (LDA)) combined with virtual reality (VR)-based binocular visual function (BVF) balance training in the prevention and control of juvenile myopia. Methods. One hundred and thirty-six juvenile myopia patients admitted between November 2018 to November 2021 were selected, including 76 cases (research group) receiving LDA + VR-based BVF balance training and 60 cases (control group) treated by LDA intervention alone. Visual acuity (VA; naked vision), ocular parameters (pupil diameter (PD), axial length

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Matsumoto, Y., Y. Sugioka, M. Tada, et al. "FRI0609-HPR NUTRIENTS INTAKE CONDITION RELATES TO MAINTENANCE LOW DISEASE ACTIVITY IN PATIENTS WITH RHEUMATOID ARTHRITIS DURING 6 YEARS: TOMORROW STUDY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 910.2–910. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4058.

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Background:We have previously reported that nutritional intake status might relate to disease activity (1). Nutritional survey on prospective cohort study in rheumatoid arthritis (RA) patients and information about relationship between nutritional intake status and disease activity was very limited.Objectives:This study aimed to obtain data from a cohort study for new nutritional therapy in RA patients.Methods:We used TOMORROW cohort study data which conducted from years of 2010 to 2020. Two hundred and eight RA patients, and 205 non-RA sex and age matched controls were investigated, and we an

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Fiore, Filippo, Nicoletta Spissu, Sara Sechi, and Raffaella Cocco. "Evaluation of Oxidative Stress in Dairy Cows with Left Displacement of Abomasum." Animals 9, no. 11 (2019): 966. http://dx.doi.org/10.3390/ani9110966.

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Left Displacement of the Abomasum (LDA) is a condition that occurs in high-producing postpartum dairy cows and it causes economic losses. Studies performed in the last decade indicate that adult dairy cows experience oxidative stress. Increasing interest in the role of oxidative status in ruminant medicine has emphasized the need to develop reliable methods to assess it. A few studies have evaluated the relationship between LDA and oxidative status, mostly through the determination of single parameters of oxidation and the determination of antioxidant status separately, with contrasting result

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Wang, Ling Xiu, and Ye Wen Cao. "Ant Colony-Based Load Balancing Algorithm for Multi-Source Multicast Networks." Advanced Materials Research 204-210 (February 2011): 1399–402. http://dx.doi.org/10.4028/www.scientific.net/amr.204-210.1399.

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IP multicast protocols tend to construct a single minimum spanning tree for a multicast source (i.e., group), in which only a few internal nodes supply multicast traffic. In multicast networks especially with multiple multicast sources where bottleneck effects may occur frequently, frequently used multicast service leads to inefficient network utilization problems. This paper presents a new network utilization algorithm for multicasting called load distribution algorithm (LDA). The LDA algorithm uses selecting candidate path based on ant colony algorithm and multicast scheduling to distribute

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Park, J. W., M. J. Kim, H. A. Kim, J. Kim, E. B. Lee, and K. Shin. "POS0628 FAILURE TO SUSTAIN TREATMENT TARGET AFTER TAPERING TOCILIZUMAB IN PATIENTS WITH RHEUMATOID ARTHRITIS: 4-YEAR LONGITUDINAL DATA FROM A NATIONWIDE COHORT." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 552.1–552. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2818.

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Background:Tapering biologic therapy after achieving clinical remission or low disease activity (LDA) has become a viable option in daily clinical practice of treating patients with rheumatoid arthritis (RA). There are yet few studies investigating its effectiveness and safety compared with those of standard biologic treatment, especially with non-tumor necrosis factor inhibitors.Objectives:To investigate the effectiveness and safety of tapering tocilizumab (TCZ) in patients with RA who attained LDA after TCZ therapy.Methods:Data were collected from a nationwide cohort of patients with RA rece

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Khachnaoui, Hajer, Nawres Khlifa, and Rostom Mabrouk. "Machine Learning for Early Parkinson’s Disease Identification within SWEDD Group Using Clinical and DaTSCAN SPECT Imaging Features." Journal of Imaging 8, no. 4 (2022): 97. http://dx.doi.org/10.3390/jimaging8040097.

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Early Parkinson’s Disease (PD) diagnosis is a critical challenge in the treatment process. Meeting this challenge allows appropriate planning for patients. However, Scan Without Evidence of Dopaminergic Deficit (SWEDD) is a heterogeneous group of PD patients and Healthy Controls (HC) in clinical and imaging features. The application of diagnostic tools based on Machine Learning (ML) comes into play here as they are capable of distinguishing between HC subjects and PD patients within an SWEDD group. In the present study, three ML algorithms were used to separate PD patients from HC within an SW

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Chi, Tianyu, Quchuan Zhao, and Peili Wang. "Fecal 16S rRNA Gene Sequencing Analysis of Changes in the Gut Microbiota of Rats with Low-Dose Aspirin-Related Intestinal Injury." BioMed Research International 2021 (April 13, 2021): 1–15. http://dx.doi.org/10.1155/2021/8848686.

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Background. The incidence of small intestinal injury caused by low-dose aspirin (LDA) is high, but the pathogenesis and intervention measures of it have not been elucidated. Recent studies have found gut microbiota to be closely associated with onset and development of NSAID-induced intestinal injury. However, studies of the changes in the gut microbiota of rats with LDA-related intestinal injury have been lacking recently. In this study, we investigated fecal 16S rRNA gene sequencing analysis of changes in the gut microbiota of rats with LDA-related intestinal injury. Methods. Sprague-Dawley

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Sakiyama, Makoto, Nobutada Fujii, Daisuke Kokuryo, and Toshiya Kaihara. "Visualization of group discussion using correspondence analysis and LDA in Ideathon." Procedia CIRP 88 (2020): 595–99. http://dx.doi.org/10.1016/j.procir.2020.05.104.

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Baldock, D., M. Thoo, R. Connolly, and E. Baynton. "AB1060 EXPLORING DISEASE ACTIVITY AND PATIENT CHARACTERISTICS IN ANKYLOSING SPONDYLITIS (AS) IN EUROPE." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1752.3–1752. http://dx.doi.org/10.1136/annrheumdis-2023-eular.564.

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BackgroundAnkylosing Spondylitis (AS) is a form of arthritis that primarily affects the spine. It causes inflammation of the spinal joints that can lead to severe, chronic pain and discomfort[1]. The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) is the most frequently used patient-reported outcome to measure disease activity in axial spondyloarthritis. There is no validated definition for disease remission using BASDAI, although a threshold of ≤3 has been used in clinical trials for low disease activity[2].ObjectivesThe objective of this study was to examine AS patient characteri

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Gee, Stephen E., Marwan Ma'ayeh, Douglas Kniss, Mark B. Landon, Steven G. Gabbe, and Kara M. Rood. "Glycemic Control and Aspirin Resistance in Patients Taking Low-Dose Aspirin for Pre-eclampsia Prevention." American Journal of Perinatology 39, no. 04 (2021): 349–53. http://dx.doi.org/10.1055/s-0041-1740250.

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Objectives To assess the association between aspirin and glycemic control in diabetic, pregnant patients, and the risk for aspirin resistance in those with poor glycemic control across gestation taking low-dose aspirin (LDA) for pre-eclampsia (PEC) prevention. Study Design We performed a secondary analysis of samples collected during the Maternal-Fetal Medicine Units trial of LDA for PEC prevention. A subset of insulin-controlled diabetic patient samples on placebo or 60 mg aspirin daily were evaluated. Glycosylated hemoglobin was measured at randomization, mid-second trimester, and third trim

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Torikai, E., Y. Hirano, D. Suzuki, and Y. Kanayama. "FRI0137 Discontinuation of baricitinib after achieving low disease activity in patients with rheumatoid arthritis in clinical practice; a multicenter observational study." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 651.2–651. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1546.

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Background:Baricitinib (bari) is an oral Janus kinase (JAK) 1/JAK2 selective inhibitor that has shown good efficacy in patients with RA and adequate response to conventional synthetic DMARDs in some clinical trials [1,2]. However, concerning the high cost and long-term safety related to the inhibition of particular molecules, we would like to discontinue bari after achieving long low disease activity (LDA).Objectives:To evaluate the clinical outcomes in patients with RA who discontinued bari after achieving LDA for 24 weeks in real-world multicenter clinical data.Methods:Japanese 67 patients w

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Su, Hang, Mei-Jun Long, Joel E. Michalek, Michael Weil, and Chul S. Ha. "P53 Downregulation-Based Strategy to Protect Genomic Integrity from Radiation Therapy." Blood 136, Supplement 1 (2020): 24–25. http://dx.doi.org/10.1182/blood-2020-139137.

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Background: Activation of p53 is one of major pathways by which DNA damaging agents (DDA) such as radiation and chemotherapy cause toxicity in normal tissues and it induces a cascade of events that eventually leads to cell senescence or cell death. We have reported that a brief pretreatment with low dose arsenic (LDA), by temporarily and reversibly downregulating p53 at the time of treatment with DDA, reduces the normal tissue toxicity without compromising tumor response to treatment. This protective effect is selective to normal tissues, as it requires functional p53. Though not every cancer

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Pakchotanon, Rattapol, Dafna D. Gladman, Jiandong Su, and Murray B. Urowitz. "More Consistent Antimalarial Intake in First 5 Years of Disease Is Associated with Better Prognosis in Patients with Systemic Lupus Erythematosus." Journal of Rheumatology 45, no. 1 (2017): 90–94. http://dx.doi.org/10.3899/jrheum.170645.

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Objective.To examine whether more consistent use of antimalarial agents (AM) leads to better results in systemic lupus erythematosus (SLE).Methods.From a longitudinal cohort study, we identified inception patients with a minimum of 5 years of followup. They were divided into 3 groups: patients who took AM > 60% of the time (group A), those who took AM < 60% of the time (group B), and those who did not receive AM (group C) during the first 5 years of followup. Outcomes included increase in Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SD

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Park, Hyeree, Tung Hoang, Min Jung Kim, Ji Won Park, Seung-Yong Jeong, and Aesun Shin. "Abstract 5892: Microbial diversity and composition according to short-term postoperative complication status in colorectal cancer patients." Cancer Research 83, no. 7_Supplement (2023): 5892. http://dx.doi.org/10.1158/1538-7445.am2023-5892.

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Abstract Background: Previous studies have suggested the disturbance in the microbial composition followed by dysbiosis contribute to the onset of gastrointestinal malignancies, including colorectal cancer (CRC). However, the impact of microbiome on short-term postoperative complications after CRC surgery is not well investigated. This study aimed to investigate whether the gut microbial diversity and composition in CRC patients were associated with the occurrence of short-term postoperative complications. Methods: We linked the clinical data and preoperative sequencing data of fecal samples o

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Zhang, Peng, Hansu Gu, Mike Gartrell, et al. "Group-based Latent Dirichlet Allocation (Group-LDA): Effective audience detection for books in online social media." Knowledge-Based Systems 105 (August 2016): 134–46. http://dx.doi.org/10.1016/j.knosys.2016.05.006.

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VAN DER HEIJDE, DÉSIRÉE, EDWARD C. KEYSTONE, JEFFREY R. CURTIS, et al. "Timing and Magnitude of Initial Change in Disease Activity Score 28 Predicts the Likelihood of Achieving Low Disease Activity at 1 Year in Rheumatoid Arthritis Patients Treated with Certolizumab Pegol: A Post-hoc Analysis of the RAPID 1 Trial." Journal of Rheumatology 39, no. 7 (2012): 1326–33. http://dx.doi.org/10.3899/jrheum.111171.

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Objective.To determine the relationship between timing and magnitude of Disease Activity Score [DAS28(ESR)] nonresponse (DAS28 improvement thresholds not reached) during the first 12 weeks of treatment with certolizumab pegol (CZP) plus methotrexate, and the likelihood of achieving low disease activity (LDA) at 1 year in patients with rheumatoid arthritis.Methods.In a post-hoc analysis of the RAPID 1 study, patients achieving LDA [DAS28(ESR) ≤ 3.2] at Year 1 were assessed according to DAS28 nonresponse at various timepoints within the first 12 weeks.Results.Seven-hundred eighty-three patients

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Hoxha, Ariela, Maria Favaro, Antonia Calligaro, et al. "Upgrading Therapy Strategy Improves Pregnancy Outcome in Antiphospholipid Syndrome: A Cohort Management Study." Thrombosis and Haemostasis 120, no. 01 (2019): 036–43. http://dx.doi.org/10.1055/s-0039-1697665.

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AbstractThe current study evaluates the efficacy and safety of different treatment strategies for pregnant patients with antiphospholipid syndrome. One hundred twenty-seven consecutive pregnancies were assessed; 87 (68.5%) with a history of pregnancy morbidity alone were treated with prophylactic low molecular weight heparin (LMWH) + low-dose aspirin (LDA, 100 mg) (group I) and 40 (31.5%) with a history of thrombosis and/or severe pregnancy complications with therapeutic LMWH + LDA (group II). LMWH doses were increased throughout the pregnancies depending on the patients' weight gain, and trea

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Hendrawan, Muhammad Yunus, and Nucke Widowati Kusumo Projo. "Topic Modelling in Knowledge Management Documents BPS Statistics Indonesia." Proceedings of The International Conference on Data Science and Official Statistics 2021, no. 1 (2022): 119–30. http://dx.doi.org/10.34123/icdsos.v2021i1.52.

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Knowledge management is an important activity in improving the performance an organization. BPS Statistics Indonesia has recently implemented such a system to improve the quality and efficiency of business processes. The purposes of this research are: 1) implementing topic modelling on BPS Knowledge Management System to identify groups of document topics; 2) providing recommendations on which the best topic modelling; 3) building a web service function of topic modelling for BPS that includes data preprocessing function and topic group recommendation function. This study applies the Latent Sem

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Spektor, Sergey, Samuel Agus, Vladimir Merkin, and Shlomo Constantini. "Low-dose aspirin prophylaxis and risk of intracranial hemorrhage in patients older than 60 years of age with mild or moderate head injury: a prospective study." Journal of Neurosurgery 99, no. 4 (2003): 661–65. http://dx.doi.org/10.3171/jns.2003.99.4.0661.

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Object. The goal of this paper was to investigate a possible relationship between the consumption of low-dose aspirin (LDA) and traumatic intracranial hemorrhage in an attempt to determine whether older patients receiving prophylactic LDA require special treatment following an incidence of mild-to-moderate head trauma. Methods. Two hundred thirty-one patients older than 60 years of age, who arrived at the emergency department with a mild or moderate head injury (Glasgow Coma Scale [GCS] Scores 13–15 and 9–12, respectively), were included in the study. One hundred ten patients were receiving pr

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Kutz, Dieter F., Stephanie Fröhlich, Julian Rudisch, Katrin Müller, and Claudia Voelcker-Rehage. "Finger Tapping as a Biomarker to Classify Cognitive Status in 80+-Year-Olds." Journal of Personalized Medicine 12, no. 2 (2022): 286. http://dx.doi.org/10.3390/jpm12020286.

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This study examined the association between finger tapping and cognitive function in a group of 225 elderly participants (116 males; age 79–92 years; M = 82.5; SD = 2.4). Finger tapping was assessed in two conditions: self-selected pace and fast pace. Based on cognitive assessments, including the MoCA and CERA-NP test battery, participants were classified as cognitively healthy individuals (CHI), participants with mild cognitive impairments (MCI), and those with possible MCI (pMCI). Results of the analyses show significant differences between groups, sex and the group × sex interaction in four

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Fraschetti, Emily C., Lauren E. Skelly, Mavra Ahmed, Emma C. Biancaniello, Panagiota Klentrou, and Andrea R. Josse. "The Influence of Increased Dairy Product Consumption, as Part of a Lifestyle Modification Intervention, on Diet Quality and Eating Patterns in Female Adolescents with Overweight/Obesity." Children 9, no. 11 (2022): 1703. http://dx.doi.org/10.3390/children9111703.

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Our study examined how increased dairy consumption versus habitually low dairy consumption, against a background of healthy eating (and exercise), influenced diet quality, nutrient intake, and snacking in Canadian female adolescents (14.8 ± 2.2 years) with overweight/obesity (OW/OB). We also explored dairy consumption patterns in the group consuming dairy products. Participants were randomized into two groups: higher/recommended dairy (RDa; 4 svg/d; n = 24) or low dairy (LDa; 0–2 svg/d; n = 23). Both groups participated in a 12-week, eucaloric, lifestyle modification intervention consisting of

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Lei, Mariana Alves Caipira, and João Simões. "Milk Beta-Hydroxybutyrate and Fat to Protein Ratio Patterns during the First Five Months of Lactation in Holstein Dairy Cows Presenting Treated Left Displaced Abomasum and Other Post-Partum Diseases." Animals 11, no. 3 (2021): 816. http://dx.doi.org/10.3390/ani11030816.

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The main objective of the present study was to evaluate the beta-hydroxybutyrate (BHB) and fat to protein content (F:P) ratio patterns in the milk of Holstein cows with postpartum diseases throughout the first five months of lactation. This prospective study was performed at Vestjyske Dyrlaeger ApS (Nørre Nebel, Denmark). The milk fat, protein, and BHB were evaluated in the Danish Eurofins laboratory according to the monthly averaged days in milk (DIM1 to 5). According to clinical records, five groups were formed: A (control group; cows without diseases; n = 32), B (cows with left displaced ab

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Jacquelin, J. M., Y. Robin, A. Godard, and G. Queguiner. "Étude de la metallation des carbamates d'hydroxy-2,3,4 quinoléines." Canadian Journal of Chemistry 66, no. 5 (1988): 1135–40. http://dx.doi.org/10.1139/v88-186.

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When N,N-dialkyl O-(quinolyl-3 or 4) carbamates are reacted with LDA in THF at −78 °C lithiation occurs regioselectively at the ortho positions (respectively at C4 and C3). With the 2-substituted isomer better results can be obtained by using sec-butyllithium/TMEDA chelate instead of LDA in THF at −105 °C. Each of the lithiated intermediates is treated with various electrophiles. The results of experiments with aldehydes afford convincing evidence of the influence of steric hindrance around the nitrogen of the carbamate functional group. Various disubstituted hydroxyquinolines have been prepar

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Eweiss, A. Z., V. J. Lund, A. Jay, and G. Rose. "Transitional cell tumours of the lacrimal drainage apparatus." Rhinology journal 51, no. 4 (2013): 349–54. http://dx.doi.org/10.4193/rhino13.016.

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Background: Tumours of the lacrimal drainage apparatus (LDA) are very rare, but can be life-threatening. Seventy percent of lacrimal sac tumours are of epithelial origin, and transitional cell tumours represent an interesting sub-group of these epithelial tumours. Methods: A retrospective review of cases of LDA transitional cell tumours co-managed at the Royal National Throat Nose and Ear Hospital and Moorfields Eye Hospital, London. Results: Twenty cases of transitional cell tumours of the LDA were identified, comprising 10 transitional cell papillomas (TCPs) and 10 transitional cell carcinom

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Hwang, Inok, HyangKyung Kim, Ji Won Lee, and Seongyong Kim. "Clustering of image annotations using online learning-based LDA model." Korean Data Analysis Society 25, no. 2 (2023): 537–48. http://dx.doi.org/10.37727/jkdas.2023.25.2.537.

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LDA model is one of the latent topic models used to investigate latent topics by analyzing documents and words in corpus, and has been widely used in various fields. However, LDA model proposed by Blei, Ng, Jordan (2003) is based on batch learning, which estimates parameters using whole data at once, which has limitations such as large memory requirement and computation time for large data. To resolve this problems, an online learning-based LDA model has been proposed. This method has been known to consume less memory and have a faster analysis speed than batch learning. In this paper, we inve

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Haloun, Tomáš, Radko Rajmon, Dalibor Řehák, et al. "Comparison of laparotomic omentopexy vs. laparoscopic abomasopexy treatments of left displaced abomasum in dairy cows under field conditions: biochemical analysis." Acta Veterinaria Brno 89, no. 3 (2020): 209–16. http://dx.doi.org/10.2754/avb202089030209.

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The objective of this retrospective study was to compare the effects of the two methods (laparoscopic or laparotomic) of LDA (left displaced abomasum) correction under field conditions by means of survival rate and biochemical profile evaluation. Holstein cows from one farm with LDA over a 20-month period were included in the study. Cows underwent laparoscopic abomasopexy (Janowitz’s method, LS) or a laparotomic right flank omentopexy (Dirksen’s method, LT). Blood samples for biochemical analysis were taken just prior to surgery (D1) and on days 10 (D10) and 30 (D30) following surgery. Blood p

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Boehncke, W. H., A. B. Gottlieb, E. Soriano, et al. "POS0082 A NOVEL PSORIATIC ARTHRITIS COMPOSITE ENDPOINT COMBINING TREATMENT TARGETS FOR SKIN AND JOINTS: POOLED RESULTS FROM THE GUSELKUMAB DISCOVER-1 AND DISCOVER-2 STUDIES." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 261–62. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1070.

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BackgroundPsoriatic arthritis (PsA) is characterized by a range of musculoskeletal and extra-articular disease manifestations. Composite indices are valuable tools to assess the multidimensional nature of PsA. The Psoriatic Arthritis Disease Activity Score (PASDAS)1 provides robust assessment of both joint and skin domains but is cumbersome to use in clinical practice. The Disease Activity Index for Psoriatic Arthritis (DAPSA)2 is relatively easy to use but does not assess skin disease.ObjectivesUsing pooled data from the phase 3 DISCOVER-1 and DISCOVER-2 studies of guselkumab (GUS) for the tr

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Sugihara, M., N. Yokogawa, and K. Shimada. "AB0358 REDUCTION OF WHITE BLOOD CELL COUNT PREDICTS THE EFFICACY OF BARICITINIB, DOES NOT OF TOFACITINIB FOR RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1479–80. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1468.

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Background:Pairing Janus kinase (JAK) 1/JAK3 signaling mediates lymphocyte proliferation and differentiation while pairing JAK2/JAK2 signaling is essential in myelopoiesis, erythropoiesis, and platelet production by facilitating signaling mediated by granulocyte-macrophage colony stimulating factor and erythropoietin. Tofacitinib (TOF) preferentially inhibits JAK1 and JAK3, while baricitinib (BAR) inhibits JAK1 and JAK2in vitro(1). However, the difference in the efficacy and the clinical courses between TOF and BAR in patients with rheumatoid arthritis (RA) remains unclear.Objectives:The objec

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Xanthos, Martin, Simon J. Mayo, and Isabel Larridon. "Reassessment of morphological species delimitations in the Cyperus margaritaceus-niveus complex using morphometrics." Plant Ecology and Evolution 156, no. 1 (2023): 112–27. http://dx.doi.org/10.5091/plecevo.97453.

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Background and aims – The Cyperus margaritaceus-niveus complex is a group of ten tropical species from sub-Saharan Africa and Madagascar: C. karlschumannii, C. kibweanus, C. ledermannii, C. margaritaceus, C. niveus, C. nduru, C. obtusiflorus, C. somaliensis, C. sphaerocephalus, and C. tisserantii. They are characterised by a capitate head of white-yellow spikelets and modified culm bases and recent molecular analysis puts them in a distinct clade. The group lacks a modern taxonomic revision, and the taxa described in the Flora treatments of the past 50 years differ considerably in their circum

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Shayan, Zahra, Naser Mohammad Gholi Mezerji, Leila Shayan, and Parisa Naseri. "Prediction of Depression in Cancer Patients With Different Classification Criteria, Linear Discriminant Analysis versus Logistic Regression." Global Journal of Health Science 8, no. 7 (2015): 41. http://dx.doi.org/10.5539/gjhs.v8n7p41.

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<p><strong>BACKGROUND: </strong>Logistic regression (LR) and linear discriminant analysis (LDA) are two popular<strong> </strong>statistical models for prediction of group membership. Although they are very similar, the LDA makes more assumptions about the data. When categorical and continuous variables used simultaneously, the optimal choice between the two models is questionable. In most studies, classification error (CE) is used to discriminate between subjects in several groups, but this index is not suitable to predict the accuracy of the outcome. The present

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El-Jack, Khalid, Korey Henderson, Anietie U. Andy, and Lauren Southwick. "Reddit Users' Questions and Concerns about Anesthesia." International Journal of Medical Students 10, no. 4 (2023): 370–74. http://dx.doi.org/10.5195/ijms.2022.1687.

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Background: Patients utilize social media in search of support networks. Reddit is one of the most popular social media sites and allows users to anonymously connect. Anesthesia patients are actively using Reddit to discuss their treatment options and experiences within the medical system. Methods: Posts published on an active Reddit forum on Anesthesia (i.e., /r/Anesthesia) were used. Big Query was used to collect posts from /r/Anesthesia. We collected 3,288 posts published between December 2015 and August 2019. We collected a control group of 3,288 posts from a Reddit forum not related to An

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