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Journal articles on the topic 'Growth plate Diseases'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Xie, Yangli, Siru Zhou, Hangang Chen, Xiaolan Du, and Lin Chen. "RECENT RESEARCH ON THE GROWTH PLATE: Advances in fibroblast growth factor signaling in growth plate development and disorders." Journal of Molecular Endocrinology 53, no. 1 (August 2014): T11—T34. http://dx.doi.org/10.1530/jme-14-0012.

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Skeletons are formed through two distinct developmental actions, intramembranous ossification and endochondral ossification. During embryonic development, most bone is formed by endochondral ossification. The growth plate is the developmental center for endochondral ossification. Multiple signaling pathways participate in the regulation of endochondral ossification. Fibroblast growth factor (FGF)/FGF receptor (FGFR) signaling has been found to play a vital role in the development and maintenance of growth plates. Missense mutations inFGFsandFGFRscan cause multiple genetic skeletal diseases wit

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Holzer, Tatjana, Kristina Probst, Julia Etich, Markus Auler, Veronika S. Georgieva, Björn Bluhm, Christian Frie, et al. "Respiratory chain inactivation links cartilage-mediated growth retardation to mitochondrial diseases." Journal of Cell Biology 218, no. 6 (May 13, 2019): 1853–70. http://dx.doi.org/10.1083/jcb.201809056.

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In childhood, skeletal growth is driven by transient expansion of cartilage in the growth plate. The common belief is that energy production in this hypoxic tissue mainly relies on anaerobic glycolysis and not on mitochondrial respiratory chain (RC) activity. However, children with mitochondrial diseases causing RC dysfunction often present with short stature, which indicates that RC activity may be essential for cartilage-mediated skeletal growth. To elucidate the role of the mitochondrial RC in cartilage growth and pathology, we generated mice with impaired RC function in cartilage. These mi

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3

Gersing, Alexandra S., Klaus Woertler, Pia M. Jungmann, Christine Bollwein, and Benedikt J. Schwaiger. "Vertebrae, Vertebral End Plates, and Disks: Concepts and Specific Pathologies." Seminars in Musculoskeletal Radiology 23, no. 05 (September 25, 2019): 489–96. http://dx.doi.org/10.1055/s-0039-1693976.

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AbstractVertebral end plates cover the osseous vertebral body. The integrity of the cartilaginous end plates is of great importance for the entire vertebral segment because the vascularized end plate provides the nutrition for the avascular disk. Yet several pathologies may occur at these end plates at the embryonic stage, in childhood to adolescence (e.g., ossification and segmentation disorders of the spine, persistent notochord, slippage of the growth plate), as well as in the mature spine of an adult (degenerative disk disease), that may impact the integrity of the cartilaginous end plate

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4

Sederquist, Bettina, Paola Fernandez-Vojvodich, Farasat Zaman, and Lars Sävendahl. "RECENT RESEARCH ON THE GROWTH PLATE: Impact of inflammatory cytokines on longitudinal bone growth." Journal of Molecular Endocrinology 53, no. 1 (April 7, 2014): T35—T44. http://dx.doi.org/10.1530/jme-14-0006.

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Children with inflammatory diseases usually display abnormal growth patterns as well as delayed puberty. This is a result of several factors related to the disease itself, such as malnutrition, hypercortisolism, and elevated levels of pro-inflammatory cytokines. These factors in combination with glucocorticoid treatment contribute to growth retardation during chronic inflammation by systemically affecting the major regulator of growth, the GH/IGF1 axis. However, recent studies have also shown evidence of a direct effect of these factors at the growth plate level. In conditions of chronic infla

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Guevara-Morales, Johana M., Michael Frohbergh, Hector Castro-Abril, Juan J. Vaca-González, Luis A. Barrera, Diego A. Garzón-Alvarado, Edward Schuchman, and Calogera Simonaro. "Growth Plate Pathology in the Mucopolysaccharidosis Type VI Rat Model—An Experimental and Computational Approach." Diagnostics 10, no. 6 (May 31, 2020): 360. http://dx.doi.org/10.3390/diagnostics10060360.

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Background: Mucopolysaccharidoses (MPS) are a group of inherited metabolic diseases caused by impaired function or absence of lysosomal enzymes involved in degradation of glycosaminoglycans. Clinically, MPS are skeletal dysplasias, characterized by cartilage abnormalities and disturbances in the process of endochondral ossification. Histologic abnormalities of growth cartilage have been reported at advanced stages of the disease, but information regarding growth plate pathology progression either in humans or in animal models, as well as its pathophysiology, is limited. Methods: Histological a

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Kosowska-Shick, Klaudia, Lois M. Ednie, Pamela McGhee, Kathy Smith, Cynthia D. Todd, Amanda Wehler, and Peter C. Appelbaum. "Incidence and Characteristics of Vancomycin Nonsusceptible Strains of Methicillin-Resistant Staphylococcus aureus at Hershey Medical Center." Antimicrobial Agents and Chemotherapy 52, no. 12 (October 6, 2008): 4510–13. http://dx.doi.org/10.1128/aac.01073-08.

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ABSTRACT All 982 methicillin-resistant Staphylococcus aureus strains collected from August 2006 to December 2007 were tested for vancomycin susceptibility by using 3-μg/ml vancomycin brain heart infusion screening plates, a vancomycin Etest, and a vancomycin/teicoplanin macro Etest. Three vancomycin-intermediate Staphylococcus aureus (VISA) (0.3%) and two heterogeneous VISA (0.2%) isolates were identified. The screening method yielded 895 cases of ≤1 colony and 87 positive results (with growth of >1 colony after 48 h); further Etests showed 82/87 isolates with growth on screening plates to

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Evans, K. D., L. E. Sheppard, D. I. Grossman, S. H. Rao, R. B. Martin, and A. M. Oberbauer. "Long Term Cyclic Pamidronate Reduces Bone Growth by Inhibiting Osteoclast Mediated Cartilage-to-Bone Turnover in the Mouse." Open Orthopaedics Journal 2, no. 1 (July 14, 2008): 121–25. http://dx.doi.org/10.2174/1874325000802010121.

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Bisphosphonates, used to treat diseases exhibiting increased osteoclast activity, reduce longitudinal bone growth through an as yet undefined mechanism. Pamidronate, an aminobisphosphonate, was given weekly to mice at 0, 1.25, or 2.50 mg/kg/wk beginning at 4 weeks of age. At 12 weeks of age, humeral length, growth plate area, regional chondrocyte cell numbers, chondrocyte apoptosis, TRAP stained osteoclast number, and osteoclast function assessed by cathepsin K immunohistochemistry were quantified. Humeral length was decreased in pamidronate treated mice compared to vehicle control mice, and c

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Jeremic, Svetlana, Vladimir Radosavljevic, and Dobrila Jakic-Dimic. "Current bacterial diseases of fresh water fishes." Biotehnologija u stocarstvu 21, no. 3-4 (2005): 141–51. http://dx.doi.org/10.2298/bah0504141j.

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From the beginning of fish cultivation, diseases have appeared as a serious problem in this branch of agriculture. In recent years, by the intensifying of production, fish diseases have become even more significant and complex field. Bacterial diseases are constant threat for fish farming, and because of rapid course and severity of clinical manifestations the represent significant part of fish pathology, and also have great economical importance. Harmful effects of bacterial diseases on fishes are: increased morbidity and mortality rate, decreased feed conversion efficiency, decreased growth

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9

Martsyniak, S. M., and S. S. Strafun. "Surgical treatment of multidimensional deformities of lower limbs before closure of the growth plate in children with rachitic diseases." TRAUMA 21, no. 2 (March 1, 2020): 17–23. http://dx.doi.org/10.22141/1608-1706.2.21.2020.202229.

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Haseeb, Abdul, Ranjan Kc, Marco Angelozzi, Charles de Charleroy, Danielle Rux, Robert J. Tower, Lutian Yao, et al. "SOX9 keeps growth plates and articular cartilage healthy by inhibiting chondrocyte dedifferentiation/osteoblastic redifferentiation." Proceedings of the National Academy of Sciences 118, no. 8 (February 17, 2021): e2019152118. http://dx.doi.org/10.1073/pnas.2019152118.

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Cartilage is essential throughout vertebrate life. It starts developing in embryos when osteochondroprogenitor cells commit to chondrogenesis, activate a pancartilaginous program to form cartilaginous skeletal primordia, and also embrace a growth-plate program to drive skeletal growth or an articular program to build permanent joint cartilage. Various forms of cartilage malformation and degeneration diseases afflict humans, but underlying mechanisms are still incompletely understood and treatment options suboptimal. The transcription factor SOX9 is required for embryonic chondrogenesis, but it

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Costantini, Alice, Mari H. Muurinen, and Outi Mäkitie. "New gene discoveries in skeletal diseases with short stature." Endocrine Connections 10, no. 5 (May 1, 2021): R160—R174. http://dx.doi.org/10.1530/ec-21-0083.

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In the last decade, the widespread use of massively parallel sequencing has considerably boosted the number of novel gene discoveries in monogenic skeletal diseases with short stature. Defects in genes playing a role in the maintenance and function of the growth plate, the site of longitudinal bone growth, are a well-known cause of skeletal diseases with short stature. However, several genes involved in extracellular matrix composition or maintenance as well as genes partaking in various biological processes have also been characterized. This review aims to describe the latest genetic findings

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12

Gubbels, Marc-Jan, Catherine Li, and Boris Striepen. "High-Throughput Growth Assay for Toxoplasma gondii Using Yellow Fluorescent Protein." Antimicrobial Agents and Chemotherapy 47, no. 1 (January 2003): 309–16. http://dx.doi.org/10.1128/aac.47.1.309-316.2003.

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ABSTRACT A high-throughput growth assay for the protozoan parasite Toxoplasma gondii was developed based on a highly fluorescent transgenic parasite line. These parasites are stably transfected with a tandem yellow fluorescent protein (YFP) and are 1,000 times more fluorescent than the wild type. Parasites were inoculated in optical-bottom 384-well culture plates containing a confluent monolayer of host cells, and growth was monitored by using a fluorescence plate reader. The signal was linearly correlated with parasite numbers over a wide array. Direct comparison of the YFP growth assay with

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Hak, Muhammad Syafrudin, Masaaki Sasaguri, Farida Kamil Sulaiman, Enny Tyasandarwati Hardono, Akira Suzuki, Seiji Nakamura, and Masamichi Ohishi. "Longitudinal Study of Effect of Hotz's Plate and Lip Adhesion on Maxillary Growth in Bilateral Cleft Lip and Palate Patients." Cleft Palate-Craniofacial Journal 49, no. 2 (March 2012): 230–36. http://dx.doi.org/10.1597/10-042.

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Objective To investigate the effects of infant orthopedic treatment and lip adhesion on maxillary growth of patients with bilateral cleft lip and palate (BCLP). Design Prospective longitudinal study. Setting The present study was conducted at the Cleft Lip and Palate Center, Harapan Kita Children and Maternity Hospital, Indonesia, and the Department of Oral and Maxillofacial Surgery, Kyushu University Hospital, Japan. Subjects The study sample consisted of 53 patients with complete BCLP and 10 noncleft patients with other diseases. Patients with BCLP were divided into three groups: H (-), 11 p

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14

Reiss, Daniel, Michael Cappello, Lisa M. Harrison, and Richard Bungiro. "An Agar Plate Method for Culturing Hookworm Larvae: Analysis of Growth Kinetics and Infectivity Compared With Standard Coproculture Techniques." American Journal of Tropical Medicine and Hygiene 77, no. 6 (December 1, 2007): 1087–90. http://dx.doi.org/10.4269/ajtmh.2007.77.1087.

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15

Briggs, Michael D., Ella P. Dennis, Helen F. Dietmar, and Katarzyna A. Pirog. "New developments in chondrocyte ER-stress and related diseases." F1000Research 9 (April 24, 2020): 290. http://dx.doi.org/10.12688/f1000research.22275.1.

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Cartilage comprises a single cell type, the chondrocyte, embedded in a highly complex extracellular matrix. Disruption to the cartilage growth plate leads to reduced bone growth and results in a clinically diverse group of conditions known as genetic skeletal diseases (GSDs). Similarly, long-term degradation of articular cartilage can lead to osteoarthritis (OA), a disease characterised by joint pain and stiffness. As professionally secreting cells, chondrocytes are particularly susceptible to endoplasmic reticulum (ER) stress and this has been identified as a core disease mechanism in a group

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Heireman, Laura, Sofie Patteet, and Sophia Steyaert. "Performance of the new ID-fungi plate using two types of reference libraries (Bruker and MSI) to identify fungi with the Bruker MALDI Biotyper." Medical Mycology 58, no. 7 (February 6, 2020): 946–57. http://dx.doi.org/10.1093/mmy/myz138.

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Abstract During the last decade, matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) has revolutionized the diagnosis of fungal infections. Recently, a new Conidia ID-fungi plate (IDFP) medium was introduced to facilitate growth and sampling of fungi. This study aimed to evaluate the IDFP for fungal MALDI-TOF MS identification by comparison with a standard fungal growth medium using two reference libraries. A total of 75 filamentous fungal isolates (including 32 dermatophytes) were inoculated on IDFP and Sabouraud-gentamicin-chloramphenicol (SGC) agar an

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Gruppo, Veronica, Christine M. Johnson, Karen S. Marietta, Hataichanok Scherman, Erin E. Zink, Dean C. Crick, Linda B. Adams, Ian M. Orme, and Anne J. Lenaerts. "Rapid Microbiologic and Pharmacologic Evaluation of Experimental Compounds against Mycobacterium tuberculosis." Antimicrobial Agents and Chemotherapy 50, no. 4 (April 2006): 1245–50. http://dx.doi.org/10.1128/aac.50.4.1245-1250.2006.

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ABSTRACT The assessment of physiochemical and pharmacological properties at early stages of drug discovery can accelerate the conversion of hits and leads into candidates for further development. A strategy for streamlined evaluation of compounds against Mycobacterium tuberculosis in the early preclinical stage is presented in this report. As a primary assay to rapidly select experimental compounds with sufficient in vitro activity, the growth inhibition microtiter plate assay was devised as an alternative to current methods. This microdilution plate assay is a liquid culture method based on s

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Bjelic, Dragana, Maja Ignjatov, Jelena Marinkovic, Nemanja Spremo, Maja Karaman, Zorica Nikolic, and Zarko Ivanovic. "Antifungal activity of indigenous Bacillus spp. isolated from soil." Zbornik Matice srpske za prirodne nauke, no. 133 (2017): 261–69. http://dx.doi.org/10.2298/zmspn1733261b.

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Biocontrol using plant growth-promoting rhizobacteria (PGPR) represents an alternative approach to disease management, since PGPR are known to promote growth and reduce diseases in various crops. Among the different PGPR, members of the genus Bacillus are prefered for most biotechnological uses due to their capability to form extremely resistant spores and produce a wide variety of metabolites with antimicrobial activity. The objective of this research was to identify antagonistic bacteria for management of the plant diseases. Eleven isolates of Bacillus spp. were obtained from the soil sample

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Bull, James J., Bruce R. Levin, and Ian J. Molineux. "Promises and Pitfalls of In Vivo Evolution to Improve Phage Therapy." Viruses 11, no. 12 (November 21, 2019): 1083. http://dx.doi.org/10.3390/v11121083.

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Phage therapy is the use of bacterial viruses (phages) to treat bacterial infections, a medical intervention long abandoned in the West but now experiencing a revival. Currently, therapeutic phages are often chosen based on limited criteria, sometimes merely an ability to plate on the pathogenic bacterium. Better treatment might result from an informed choice of phages. Here we consider whether phages used to treat the bacterial infection in a patient may specifically evolve to improve treatment on that patient or benefit subsequent patients. With mathematical and computational models, we expl

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TOSHIMA, H., M. HACHIO, Y. IKEMOTO, J. OGASAWARA, A. HASE, K. TAKAHASHI, H. MASAKI, and Y. NISHIKAWA. "Prevalence of enteric bacteria that inhibit growth of enterohaemorrhagic Escherichia coli O157 in humans." Epidemiology and Infection 135, no. 1 (June 2, 2006): 110–17. http://dx.doi.org/10.1017/s0950268806006510.

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Enterohaemorrhagic Escherichia coli O157 (O157) is infectious to humans, particularly children, at very low doses and causes not only haemorrhagic colitis but also other serious symptoms. To investigate an association between intestinal bacterial flora and resistance to such infections, we screened faecal samples for the presence of enteric bacteria that are able to suppress the growth of O157. Samples from 303 individuals, 35 children (aged [les ]6 years) and 268 adults (aged 20–59 years), were examined. Colonies with different appearances on sorbitol MacConkey agar medium were screened for t

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Kiso, Tetsuo, Ken-Ichi Fujita, Xu Ping, Toshio Tanaka, and Makoto Taniguchi. "Screening for Microtubule-Disrupting Antifungal Agents by Using a Mitotic-Arrest Mutant of Aspergillus nidulans and Novel Action of Phenylalanine Derivatives Accompanying Tubulin Loss." Antimicrobial Agents and Chemotherapy 48, no. 5 (May 2004): 1739–48. http://dx.doi.org/10.1128/aac.48.5.1739-1748.2004.

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ABSTRACT The microtubule, which is one of the major targets of anthelmintics, anticancer drugs, and fungicides, is composed mainly of α- and β-tubulins. We focused on a unique characteristic of an Aspergillus nidulans benA33 mutant to screen for microtubule-disrupting antifungal agents. This mutant, which has a β-tubulin with a mutation of a single amino acid, undergoes mitotic arrest due to the formation of hyperstable microtubules at 37°C. The heat sensitivity of the mutant is remedied by some antimicrotubule agents. We found that an agar plate assay with the mutant was able to distinguish t

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Hershberger, Ellie, and Michael J. Rybak. "Activities of Trovafloxacin, Gatifloxacin, Clinafloxacin, Sparfloxacin, Levofloxacin, and Ciprofloxacin against Penicillin-Resistant Streptococcus pneumoniae in an In Vitro Infection Model." Antimicrobial Agents and Chemotherapy 44, no. 3 (March 1, 2000): 598–601. http://dx.doi.org/10.1128/aac.44.3.598-601.2000.

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ABSTRACT We adapted an in vitro pharmacodynamic model of infection to incorporate infected fibrin clots. The bactericidal activities of various fluoroquinolones against two strains of penicillin-resistantStreptococcus pneumoniae were studied over a 48-h period. Bacteria were prepared in Muller-Hinton broth by using colonies from a 24-h tryptic soy agar plus 5% sheep blood plate and were added to a mixture of cryoprecipitate (80%) and thrombin (10%) to achieve approximately 106 CFU of organism per fibrin clot. The fibrin clots were suspended into the models and removed, in triplicate, at variou

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Smith, M. G. "Calculation of the expected increases of coliform organisms,Escherichia coliandSalmonella typhimurium, in raw blended mutton tissue." Epidemiology and Infection 99, no. 2 (October 1987): 323–31. http://dx.doi.org/10.1017/s0950268800067790.

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SUMMARYSamples of blended mutton tissue in small polyvinyl chloride sachets were incubated in water baths for different times and at varying temperatures. The temperature of each bath was recorded accurately throughout each experiment. Using equations previously derived for the lag and generation times of coliform organisms in blended mutton tissue, the expected increases of these bacteria were calculated from the time/temperature recordings. These were compared with the data obtained from plate counts made on the tissue samples in the sachets before and after incubation. The studies were done

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Pi, Rui, Qingyun Liu, Qi Jiang, and Qian Gao. "Characterization of linezolid-resistance-associated mutations in Mycobacterium tuberculosis through WGS." Journal of Antimicrobial Chemotherapy 74, no. 7 (April 23, 2019): 1795–98. http://dx.doi.org/10.1093/jac/dkz150.

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Abstract Objectives Linezolid is becoming an important antibiotic for treating MDR/XDR TB, but the mutations conferring resistance to linezolid remain inadequately characterized. Herein, we investigated the linezolid-resistance-associated mutations on a whole-genome scale through parallel selections of resistant isolates in vitro. Methods Ten parallel Mycobacterium tuberculosis H37Rv cultures were subjected to spontaneous mutant selection on 7H11 agar plates containing 2.5 mg/L linezolid. The linezolid resistance of resulting colonies was confirmed by growth on a second linezolid plate. WGS wa

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Sohaskey, Charles D., and Alan G. Barbour. "Esterases in Serum-Containing Growth Media Counteract Chloramphenicol Acetyltransferase Activity In Vitro." Antimicrobial Agents and Chemotherapy 43, no. 3 (March 1, 1999): 655–60. http://dx.doi.org/10.1128/aac.43.3.655.

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ABSTRACT The spirochete Borrelia burgdorferi was unexpectedly found to be as susceptible to diacetyl chloramphenicol, the product of the enzyme chloramphenicol acetyltransferase, as it was to chloramphenicol itself. The susceptibilities of Escherichia coli and Bacillus subtilis, as well as that ofB. burgdorferi, to diacetyl chloramphenicol were then assayed in different media. All three species were susceptible to diacetyl chloramphenicol when growth media were supplemented with rabbit serum or, to a lesser extent, human serum. Susceptibility ofE. coli and B. subtilis to diacetyl chloramphenic

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Costa, Daniela, Rui M. Tavares, Paula Baptista, and Teresa Lino-Neto. "Cork Oak Endophytic Fungi as Potential Biocontrol Agents against Biscogniauxia mediterranea and Diplodia corticola." Journal of Fungi 6, no. 4 (November 14, 2020): 287. http://dx.doi.org/10.3390/jof6040287.

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An increase in cork oak diseases caused by Biscogniauxia mediterranea and Diplodia corticola has been reported in the last decade. Due to the high socio-economic and ecologic importance of this plant species in the Mediterranean Basin, the search for preventive or treatment measures to control these diseases is an urgent need. Fungal endophytes were recovered from cork oak trees with different disease severity levels, using culture-dependent methods. The results showed a higher number of potential pathogens than beneficial fungi such as cork oak endophytes, even in healthy plants. The antagoni

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Höppner, Jakob, Katja Steff, Felix Lobert, Christoph M. Heyer, Berthold P. Hauffa, and Corinna Grasemann. "Rhizomelia and Impaired Linear Growth in a Girl with Juvenile Paget Disease: The Natural History of the Condition." Hormone Research in Paediatrics 94, no. 3-4 (2021): 151–58. http://dx.doi.org/10.1159/000517164.

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In ultra-rare bone diseases, information on growth during childhood is sparse. Juvenile Paget disease (JPD) is an ultra-rare disease, characterized by loss of function of osteoprotegerin (OPG). OPG inhibits osteoclast activation via the receptor activator of nuclear factor-κB (RANK) pathway. In JPD, overactive osteoclasts result in inflammatory-like bone disease due to grossly elevated bone resorption. Knowledge on the natural history of JPD, including final height and growth, is limited. Most affected children receive long-term antiresorptive treatment, mostly with bisphosphonates, to contain

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Perugorria, Maria J., Ibone Labiano, Aitor Esparza-Baquer, Marco Marzioni, Jose J. G. Marin, Luis Bujanda, and Jesús M. Banales. "Bile Acids in Polycystic Liver Diseases: Triggers of Disease Progression and Potential Solution for Treatment." Digestive Diseases 35, no. 3 (2017): 275–81. http://dx.doi.org/10.1159/000450989.

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Polycystic liver diseases (PLDs) are a group of genetic hereditary cholangiopathies characterized by the development and progressive growth of cysts in the liver, which are the main cause of morbidity. Current therapies are based on surgical procedures and pharmacological strategies, which show short-term and modest beneficial effects. Therefore, the determination of the molecular mechanisms of pathogenesis appears to be crucial in order to find new potential targets for pharmacological therapy. Ductal plate malformation during embryogenesis and abnormal cystic cholangiocyte growth and secreti

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MacRae, V. E., T. Burdon, S. F. Ahmed, and C. Farquharson. "Ceramide inhibition of chondrocyte proliferation and bone growth is IGF-I independent." Journal of Endocrinology 191, no. 2 (November 2006): 369–77. http://dx.doi.org/10.1677/joe.1.06958.

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Proinflammatory cytokines inhibit growth plate development. However, their underlying mechanisms of action are unclear. These effects may be mediated by ceramide, a sphingosine-based lipid second messenger, which is elevated in a number of chronic inflammatory diseases. To test this hypothesis, we determined the effects of C2-ceramide, a cell permeable ceramide analogue, on the growth of the ATDC5 chondrogenic cell line and on cultured fetal mice metatarsals. In ATDC5 cells, C2-ceramide significantly induced apoptosis at both 40 (82%; P < 0.05) and 25 μM (53%; P < 0.05). At 40 μM, C2-cer

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Johnson, Jacob D., Richard A. Dennull, Lucia Gerena, Miriam Lopez-Sanchez, Norma E. Roncal, and Norman C. Waters. "Assessment and Continued Validation of the Malaria SYBR Green I-Based Fluorescence Assay for Use in Malaria Drug Screening." Antimicrobial Agents and Chemotherapy 51, no. 6 (March 19, 2007): 1926–33. http://dx.doi.org/10.1128/aac.01607-06.

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ABSTRACT Several new fluorescence malaria in vitro drug susceptibility microtiter plate assays that detect the presence of malarial DNA in infected erythrocytes have recently been reported, in contrast to traditional isotopic screens that involve radioactive substrate incorporation to measure in vitro malaria growth inhibition. We have assessed and further characterized the malaria SYBR Green I-based fluorescence (MSF) assay for its ability to monitor drug resistance. In order to use the MSF assay as a drug screen, all assay conditions must be thoroughly examined. In this study we expanded upo

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Shin, Sung Jae, and Michael T. Collins. "Thiopurine Drugs Azathioprine and 6-Mercaptopurine Inhibit Mycobacterium paratuberculosis Growth In Vitro." Antimicrobial Agents and Chemotherapy 52, no. 2 (December 10, 2007): 418–26. http://dx.doi.org/10.1128/aac.00678-07.

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ABSTRACT The in vitro susceptibility of human- and bovine-origin Mycobacterium paratuberculosis to the thioupurine drugs 6-mercaptopurine (6-MP) and azathioprine (AZA) was established using conventional plate counting methods and the MGIT 960 ParaTB culture system. Both 6-MP and AZA had antibacterial activity against M. paratuberculosis; isolates from Crohn's disease patients tended to be more susceptible than were bovine-origin isolates. Isolates of Mycobacterium avium, used as controls, were generally resistant to both AZA and 6-MP, even at high concentrations (≥64.0 μg/ml). Among rapidly gr

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Hasan, Akhmad Endang Zainal, I. Made Artika, and Syaeful Abidin. "Produksi Asam Laktat dan Pola Pertumbuhan Bakteri Asam Laktat dengan Pemberian Dosis Rendah Propolis Trigona spp asal Pandeglang Indonesia." Current Biochemistry 1, no. 3 (November 25, 2016): 126–35. http://dx.doi.org/10.29244/cb.1.3.126-135.

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Propolis is known to have an antimicrobial activity and can prevent various diseases. Propolis consumption is feared to have negative impact on the activity of digestive lactid acid bacteria (LAB). The aim of this research was to examine the effect of propolis on the growth and lactic acid production of three LAB. Ethanol Extraction Propolis (EEP) concentrations examined were control, eep and X propolis 0% (control), 0.2%, 0.6%, 1.0% and X propolis at 0.4% concentration. The parameters analyzed were the growth of bacteria counted with Total Plate Count (TPC) method and lactic acid production u

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Turovskiy, Yevgeniy, Thomson Cheryian, Ammar Algburi, Ruth E. Wirawan, Paul Takhistov, Patrick J. Sinko та Michael L. Chikindas. "Susceptibility ofGardnerella vaginalisBiofilms to Natural Antimicrobials Subtilosin,ε-Poly-L-Lysine, and Lauramide Arginine Ethyl Ester". Infectious Diseases in Obstetrics and Gynecology 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/284762.

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Bacterial vaginosis is a common vaginal infection associated with numerous gynecological and obstetric complications. This condition is characterized by the presence of thick adherent vaginal biofilms, composed mainly ofGardnerella vaginalis. This organism is thought to be the primary aetiological cause of the infection paving the way for various opportunists to colonize the niche. Previously, we reported that the natural antimicrobials subtilosin,ε-poly-L-lysine, and lauramide arginine ethyl ester selectively inhibit the growth of this pathogen. In this study, we used plate counts to evaluate

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Bang, C., A. Schilhabel, K. Weidenbach, A. Kopp, T. Goldmann, T. Gutsmann, and R. A. Schmitz. "Effects of Antimicrobial Peptides on Methanogenic Archaea." Antimicrobial Agents and Chemotherapy 56, no. 8 (May 14, 2012): 4123–30. http://dx.doi.org/10.1128/aac.00661-12.

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ABSTRACTAs members of the indigenous human microbiota found on several mucosal tissues,Methanobrevibacter smithiiandMethanosphaera stadtmanaeare exposed to the effects of antimicrobial peptides (AMPs) secreted by these epithelia. Although antimicrobial and molecular effects of AMPs on bacteria are well described, data for archaea are not available yet. Besides, it is not clear whether AMPs affect them as the archaeal cell envelope differs profoundly in terms of chemical composition and structure from that of bacteria. The effects of different synthetic AMPs on growth ofM. smithii,M. stadtmanae

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Whaley, Sarah G., Sarah Tsao, Sandra Weber, Qing Zhang, Katherine S. Barker, Martine Raymond, and P. David Rogers. "TheRTA3Gene, Encoding a Putative Lipid Translocase, Influences the Susceptibility of Candida albicans to Fluconazole." Antimicrobial Agents and Chemotherapy 60, no. 10 (August 1, 2016): 6060–66. http://dx.doi.org/10.1128/aac.00732-16.

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ABSTRACTTheRTA3gene, coding for a member of the Rta1p-like lipid-translocating exporter family, is coordinately upregulated with the ATP-binding cassette transporter genesCDR1andCDR2in azole-resistant clinical isolates ofCandida albicansthat carry activating mutations in the transcription factor Tac1p. We show here that deletingRTA3in an azole-resistant clinical isolate carrying a Tac1p-activating mutation lowered fluconazole resistance by 2-fold, while overexpressingRTA3in an azole-susceptible clinical isolate resulted in enhanced fluconazole tolerance associated with trailing growth in a liq

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Stenholm, Teppo, Antti J. Hakanen, Jonne Vaarno, Sari Pihlasalo, Perttu Terho, Pekka E. Hänninen, Jaana Vuopio-Varkila, Pentti Huovinen, and Pirkko Kotilainen. "Methicillin-Resistant Staphylococcus aureus Screening by Online Immunometric Monitoring of Bacterial Growth under Selective Pressure." Antimicrobial Agents and Chemotherapy 53, no. 12 (September 14, 2009): 5088–94. http://dx.doi.org/10.1128/aac.00518-09.

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ABSTRACT Rapid, high-throughput screening tools are needed to contain the spread of hospital-acquired methicillin (meticillin)-resistant Staphylococcus aureus (MRSA) strains. Most techniques used in current clinical practice still require time-consuming culture for primary isolation of the microbe. We present a new phenotypic assay for MRSA screening. The technique employs a two-photon excited fluorescence (TPX) detection technology with S. aureus-specific antibodies that allows the online monitoring of bacterial growth in a single separation-free process. Different progressions of fluorescenc

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Staines, K. A., A. S. Pollard, I. M. McGonnell, C. Farquharson, and A. A. Pitsillides. "Cartilage to bone transitions in health and disease." Journal of Endocrinology 219, no. 1 (August 19, 2013): R1—R12. http://dx.doi.org/10.1530/joe-13-0276.

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Aberrant redeployment of the ‘transient’ events responsible for bone development and postnatal longitudinal growth has been reported in some diseases in what is otherwise inherently ‘stable’ cartilage. Lessons may be learnt from the molecular mechanisms underpinning transient chondrocyte differentiation and function, and their application may better identify disease aetiology. Here, we review the current evidence supporting this possibility. We firstly outline endochondral ossification and the cellular and physiological mechanisms by which it is controlled in the postnatal growth plate. We the

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Janaki, T. "BIOCONTROL OF FUSARIUM OXYSPORUM IN UNSTERILIZED SOIL BY NOVEL STREPTOMYCES CACAOI SUBSP CACAOI [M20]." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 3 (February 3, 2017): 78. http://dx.doi.org/10.22159/ijpps.2017v9i3.16579.

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Objective: To find bio fungicide from mangrove actinomycetes for controlling seed and soil borne pathogen-Fusarium oxysporum. Methods: A total of 25 actinomycetes were isolated by pour plate method. These were screened for fungicidal activity by agar plug method. The isolate M20 was characterised further for identification. The phytotoxicity study was done; biocontrol of Fusarium oxysporum with 10% culture filtrate was done using food poisoning technique. Volatile toxicity of isolate M20 was studied by inverted plate technique. The methanolic crude extract was subjected for UV–Vis spectral ana

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Simsa-Maziel, Stav, та Efrat Monsonego-Ornan. "Interleukin-1β Promotes Proliferation and Inhibits Differentiation of Chondrocytes through a Mechanism Involving Down-Regulation of FGFR-3 and p21". Endocrinology 153, № 5 (4 квітня 2012): 2296–310. http://dx.doi.org/10.1210/en.2011-1756.

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The proinflammatory cytokine IL-1β is elevated in many childhood chronic inflammatory diseases as well as obesity and can be associated with growth retardation. Here we show that IL-1β affects bone growth by directly disturbing the normal sequence of events in the growth plate, resulting in increased proliferation and widening of the proliferative zone, whereas the hypertrophic zone becomes disorganized, with impaired matrix structure and increased apoptosis and osteoclast activity. This was also evident in vitro: IL-1β increased proliferation and caused a G1-to-S phase shift in the cell cycle

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Malkoski, Marina, Stuart G. Dashper, Neil M. O'Brien-Simpson, Gert H. Talbo, Mary Macris, Keith J. Cross, and Eric C. Reynolds. "Kappacin, a Novel Antibacterial Peptide from Bovine Milk." Antimicrobial Agents and Chemotherapy 45, no. 8 (August 1, 2001): 2309–15. http://dx.doi.org/10.1128/aac.45.8.2309-2315.2001.

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ABSTRACT Caseinomacropeptide (CMP) is a heterogeneous C-terminal fragment (residues 106 to 169) of bovine milk κ-casein composed of glycosylated and phosphorylated forms of different genetic variants. We have demonstrated that CMP has growth-inhibitory activity against the oral opportunistic pathogens Streptococcus mutans andPorphyromonas gingivalis and against Escherichia coli. CMP was fractionated using reversed-phase high-performance liquid chromatography (RP-HPLC), and each fraction was tested for activity against S. mutans in a 96-well-plate broth assay. Fractions were characterized by N-

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Frazier, Kendall S. "Drug-induced Physeal Abnormalities in Preclinical Toxicity Studies." Toxicologic Pathology 45, no. 7 (June 23, 2017): 869–75. http://dx.doi.org/10.1177/0192623317713319.

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Most toxic physeal changes are characterized microscopically by altered chondrocyte development, proliferation, or maturation in the growth plate and eventually result in disordered appositional bone growth. Many therapeutic drugs directly or indirectly target proteins involved in chondrocytic differentiation and maturation pathways, so toxic physeal injury has become increasingly common in preclinical toxicologic pathology. While physeal dysplasia has been associated with several different drug classes including bisphosphonates, vascular endothelial growth factor receptor inhibitors, fibrobla

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Bouillon, Roger, Geert Carmeliet, Lieve Verlinden, Evelyne van Etten, Annemieke Verstuyf, Hilary F. Luderer, Liesbet Lieben, Chantal Mathieu, and Marie Demay. "Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice." Endocrine Reviews 29, no. 6 (October 1, 2008): 726–76. http://dx.doi.org/10.1210/er.2008-0004.

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Abstract The vitamin D endocrine system is essential for calcium and bone homeostasis. The precise mode of action and the full spectrum of activities of the vitamin D hormone, 1,25-dihydroxyvitamin D [1,25-(OH)2D], can now be better evaluated by critical analysis of mice with engineered deletion of the vitamin D receptor (VDR). Absence of a functional VDR or the key activating enzyme, 25-OHD-1α-hydroxylase (CYP27B1), in mice creates a bone and growth plate phenotype that mimics humans with the same congenital disease or severe vitamin D deficiency. The intestine is the key target for the VDR b

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Dharmaputra, Okky Setyawati, Lisdar Idwan Sudirman, and Evarini Anna Ratnaningsih. "Mikobiota pada Buah Pisang Kultivar Lampung untuk Pengendalian Hayati Fusarium semitectum." Jurnal Fitopatologi Indonesia 14, no. 1 (September 20, 2018): 30. http://dx.doi.org/10.14692/jfi.14.1.30.

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Fusarium semitectum is a pathogenic fungus causing fruit rot of banana fruits. Biological control agents have been used as an alternative to control postharvest diseases. The objective of this study was to test antagonistic potential of mycobiota of banana fruits (Musa cuminata cultivar Lampung) against F. semitectum BIO 91055. The tested fungi were isolated from healthy banana cultivar Lampung collected from Gembrong market located in Bogor using serial dilution method, followed by pour plate method. Test of antagonism activity was carried out using dual culture method. Seventeen fungal isola

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Malik, Muhammad, Kalyan Chavda, Xilin Zhao, Nirali Shah, Syed Hussain, Natalia Kurepina, Barry N. Kreiswirth, Robert J. Kerns, and Karl Drlica. "Induction of Mycobacterial Resistance to Quinolone Class Antimicrobials." Antimicrobial Agents and Chemotherapy 56, no. 7 (May 7, 2012): 3879–87. http://dx.doi.org/10.1128/aac.00474-12.

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ABSTRACTAn agar plate assay was developed for detecting the induction of drug-resistant mycobacterial mutants during exposure to inhibitors of DNA gyrase. WhenMycobacterium smegmatison drug-containing agar, resistant colonies arose over a period of 2 weeks. ArecAdeficiency reduced mutant recovery, consistent with involvement of the SOS response in mutant induction. The C-8-methoxy compounds gatifloxacin and moxifloxacin allowed the recovery of fewer resistant mutants than either ciprofloxacin or levofloxacin when present at the same multiple of the MIC; a quinolone-like 8-methoxy-quinazoline-2

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Maitra, Arundhati, Dimitrios Evangelopoulos, Alina Chrzastek, Liam T. Martin, Aidan Hanrath, Ellie Chapman, Helen C. Hailes, et al. "Carprofen elicits pleiotropic mechanisms of bactericidal action with the potential to reverse antimicrobial drug resistance in tuberculosis." Journal of Antimicrobial Chemotherapy 75, no. 11 (August 13, 2020): 3194–201. http://dx.doi.org/10.1093/jac/dkaa307.

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Abstract Background The rise of antimicrobial drug resistance in Mycobacterium tuberculosis coupled with the shortage of new antibiotics has elevated TB to a major global health priority. Repurposing drugs developed or used for other conditions has gained special attention in the current scenario of accelerated drug development for several global infectious diseases. In a similar effort, previous studies revealed that carprofen, a non-steroidal anti-inflammatory drug, selectively inhibited the growth of replicating, non-replicating and MDR clinical isolates of M. tuberculosis. Objectives We ai

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Ganim, Christine, Mustafa Mazher, and Erin Breaker. "Establishment of a Sink Gallery to Investigate Growth of Carbapenemase-Producing Klebsiella pneumoniae and Biofilms in P-Traps." Infection Control & Hospital Epidemiology 41, S1 (October 2020): s219—s220. http://dx.doi.org/10.1017/ice.2020.763.

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Background: Hand-hygiene sink drains in healthcare facilities may provide an environment for the survival and dissemination of various multidrug-resistant organisms (MDROs), including carbapenemase-producing Klebsiella pneumoniae (CPKP). We developed a sink model system to establish and test native drinking water biofilms containing CPKP in the p-traps of hand-hygiene sink drains. Methods: A handwashing sink gallery was designed to consist of 6-wall mounted stainless-steel sink basins connected to the same municipal water line. Each sink’s plumbing included a chrome-plated brass p-trap. Health

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de Cózar, Cristina, Iván Caballero, Gonzalo Colmenarejo, Laura M. Sanz, Emilio Álvarez-Ruiz, Francisco-Javier Gamo, and Concepción Cid. "Development of a Novel High-Density [3H]Hypoxanthine Scintillation Proximity Assay To Assess Plasmodium falciparum Growth." Antimicrobial Agents and Chemotherapy 60, no. 10 (July 25, 2016): 5949–56. http://dx.doi.org/10.1128/aac.00433-16.

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ABSTRACTThe discovery and development of new antimalarial drugs are becoming imperative because of the spread of resistance to current clinical treatments. The lack of robustly validated antimalarial targets and the difficulties with the building in of whole-cell activity in screening hits are hampering target-based approaches. However, phenotypic screens of structurally diverse molecule libraries are offering new opportunities for the identification of novel antimalarials. Several methodologies can be used to determine the whole-cellin vitropotencies of antimalarial hits. The [3H]hypoxanthine

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Xu, Jianping, Chiatogu Onyewu, Heather J. Yoell, Rabia Y. Ali, Rytas J. Vilgalys, and Thomas G. Mitchell. "Dynamic and Heterogeneous Mutations to Fluconazole Resistance in Cryptococcus neoformans." Antimicrobial Agents and Chemotherapy 45, no. 2 (February 1, 2001): 420–27. http://dx.doi.org/10.1128/aac.45.2.420-427.2001.

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ABSTRACT Infections with the human pathogenic basidiomycetous yeastCryptococcus neoformans are often treated with fluconazole. Resistance to this antifungal agent has been reported. This study investigated the patterns of mutation to fluconazole resistance inC. neoformans in vitro. The MIC of fluconazole was measured for 21 strains of C. neoformans. The MICs for these 21 strains differed (0.25 to 4.0 μg/ml), but the strains were selected for this study because they exhibited no growth on plates of yeast morphology agar (YMA) containing 8 μg of fluconazole per ml. To determine their mutation ra

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Nahdah, Fauziyyah, Noorkomala Sari, Akhmad Rizali, and Rabiatul Wahdah. "Antagonisme Fungi Endofit Daun Jarak Pagar (Jatropha curcas) terhadap Fusarium oxysporum C2 Penyebab Busuk Umbi pada Bawang Merah in Vitro." Agrotechnology Research Journal 4, no. 1 (June 25, 2020): 47. http://dx.doi.org/10.20961/agrotechresj.v4i1.41351.

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<p class="Abstract">Basal plate rot is a major disease on shallot caused by <em>Fusarium oxysporum</em>. Endophytic fungi is promising to use as antagonist agent to the pathogen. Endophyte is microbes that are living in plant cells and have an asymptomatic characteristic. Nowadays, fungal endophyte is believed to produce antimicrobial substances similar with their plant host's natural product. <em>Jatropha curcas</em> is one of the plants containing secondary metabolites that have antifungal activities. The research aimed to study the ability of endophyte from &lt

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Wu, Meng-Chuan, Ying-Chun Chen, Tzu-Lung Lin, Pei-Fang Hsieh, and Jin-Town Wang. "Cellobiose-Specific Phosphotransferase System of Klebsiella pneumoniae and Its Importance in Biofilm Formation and Virulence." Infection and Immunity 80, no. 7 (May 7, 2012): 2464–72. http://dx.doi.org/10.1128/iai.06247-11.

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ABSTRACTKlebsiella pneumoniaeis a Gram-negative bacillus belonging to the familyEnterobacteriaceae. In the past 20 years,K. pneumoniaehas become the predominant pathogen causing community-acquired pyogenic liver abscess (PLA). The formation of biofilm facilitates bacterial colonization and has been implicated in reduced susceptibility to the host immune response. To investigate genes related to biofilm formation in a PLA-associatedK. pneumoniaestrain, a transposon mutant library was screened by microtiter plate assay to identify isolates impaired for biofilm formation. One of the mutants was d

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