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Journal articles on the topic 'GSTM1; GSTT1 Polymorphisms; Oral Cancer'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Gupta, Shalini, and Somali Sanyal. "Metabolic Gene Polymorphisms and Antioxidant Influence Risk of Pre Oral Cancer and Oral Cancer." Cancer Research and Cellular Therapeutics 7, no. 1 (2023): 01–10. http://dx.doi.org/10.31579/2640-1053/129.

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Many polymorphic genes that code enzymes involved in carcinogen biotransformation have been reported to be associated with development of cancer. GSTT1, GSTM1 genes that code phase II enzyme belongs to the glutathione S-transferases (GSTs) family and seems relevant for the susceptibility to oral diseases as it detoxify carcinogenic tobacco smoke to its excretal form. The aim of our study was to determine the association of GSTT1, GSTM1non null/null polymorphisms with the plasma level of GR, GSH and GST and susceptibility in pre oral cancer and oral cancer in North Indian population. The study

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Sreelekha, T. T., K. Ramadas, M. Pandey, G. Thomas, K. R. Nalinakumari, and M. R. Pillai. "Genetic polymorphism of CYP1A1, GSTM1 and GSTT1 genes in Indian oral cancer." Oral Oncology 37, no. 7 (2001): 593–98. http://dx.doi.org/10.1016/s1368-8375(01)00028-8.

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3

Krüger, Maximilian, Andreas Max Pabst, Benjamin Mahmoodi, Burkhard Becker, Peer Wolfgang Kämmerer, and Felix Peter Koch. "The impact of GSTM1/GSTT1 polymorphism for the risk of oral cancer." Clinical Oral Investigations 19, no. 8 (2015): 1791–97. http://dx.doi.org/10.1007/s00784-015-1400-0.

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4

Varela-Lema, L., A. Ruano-Ravina, M. A. Juiz Crespo, K. T. Kelsey, L. Loidi, and J. M. Barros-Dios. "CYP1A1, mEH, and GSTM1 Polymophisms and Risk of Oral and Pharyngeal Cancer: A Spanish Case-Control Study." Journal of Oncology 2008 (2008): 1–11. http://dx.doi.org/10.1155/2008/741310.

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Background. Genetic polymorphisms of drug metabolizing enzymes involved in the detoxification pathways of carcinogenic substances may influence cancer risk.Methods. Case-control study that investigates the relationship between CYP1A1 Ile/Val, exon 4 mEH, and GSTM1 null genetic polymorphism and the risk of oral and pharyngeal cancer examining the interaction between these genes, tobacco, and alcohol. 92 incident cases and 130 consecutive hospital-based controls have been included.Results. No significant associations were found for any of the genotypes assessed. The estimated risk was slightly e

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Pradhan, Devina, Tarang Mehta, Arpita Srivastava, et al. "Evaluation of the Importance of Genetic Polymorphisms in Genes Expressing Cancer-Metabolizing Enzymes (Cyp1a1 and Gstm1) in Oral Submucous Fibrosis." Journal of Pharmacy and Bioallied Sciences 16, Suppl 3 (2024): S2785—S2787. http://dx.doi.org/10.4103/jpbs.jpbs_413_24.

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ABSTRACT Background: Genetic polymorphisms are common and contribute significantly to human illnesses. Aim: This study was carried out to evaluate the importance of genetic variations in the genes expressing cancer-metabolizing enzymes (CYP1A1 and GSTM1) in individuals experiencing oral submucous fibrosis (OSMF). Methods and Materials: Based on the clinical and histological characteristics of OSMF, 40 patients were chosen for the study; 10 of these patients had considerable polymorphism and malignant transformation; therefore, they were placed in a different group. After receiving written agre

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6

Buch, S. C. "Polymorphism at GSTM1, GSTM3 and GSTT1 gene loci and susceptibility to oral cancer in an Indian population." Carcinogenesis 23, no. 5 (2002): 803–7. http://dx.doi.org/10.1093/carcin/23.5.803.

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7

Tanwar Renu, Asha R. Iyengar, and Kekkeri Sitaram Nagesh. "GSTM1 null polymorphism – a possible key for oral carcinogenesis." RSBO 10, no. 1 (2014): 76–81. http://dx.doi.org/10.21726/rsbo.v10i1.899.

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Carcinogenesis is a multistep process and individual risk to development of cancer depends not only on environmental factors or extrinsic exposure to carcinogens but also on genetic susceptibility of an individual. In head and neck cancer, tobacco exposure and alcohol consumption are predominantly the most significant external factors for tumor formation. Individual’s susceptibility to cancer may be partly explained by variability in enzymatic activities of metabolic genes. Mutations in genes concerned with production of enzymes for metabolism of tobacco products may lead to increased risk of

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8

Sharma, Tusha, Basu D. Banerjee, Gaurav K. Thakur, Kiran Guleria, and Darshana Mazumdar. "Polymorphism of xenobiotic metabolizing gene and susceptibility of epithelial ovarian cancer with reference to organochlorine pesticides exposure." Experimental Biology and Medicine 244, no. 16 (2019): 1446–53. http://dx.doi.org/10.1177/1535370219878652.

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The transformation of ovarian surface epithelial cells, stromal cells, sex cord, or germ cells initiates ovarian malignancy. Epithelial ovarian cancer (EOC) is clinically silent with vague, non-specific symptomatology and is generally diagnosed at an advanced stage, resulting in a high mortality rate. The known main etiological factors are: age at menarche and menopause (early menarche or late menopause), use of oral contraception (estrogen and/or progesterone), family history, genetic factors, inflammation, occupational and environmental exposure. The study is intended to assess the associati

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9

Anantharaman, Devasena, Pranay M. Chaubal, Sadhana Kannan, Rajani A. Bhisey, and Manoj B. Mahimkar. "Susceptibility to oral cancer by genetic polymorphisms at CYP1A1, GSTM1 and GSTT1 loci among Indians: tobacco exposure as a risk modulator." Carcinogenesis 28, no. 7 (2007): 1455–62. http://dx.doi.org/10.1093/carcin/bgm038.

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10

Madhulatha, G., Satrupa Das, N. Venkateswarlu, Akhilesh Pujar, Akka Jyothy, and Anjana Munshi. "GSTM1 and GSTT1 null polymorphism and antioxidant levels in oral submucous fibrosis, leukoplakia and oral cancer patients among a South Indian Population." Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 30, no. 2 (2018): 169–74. http://dx.doi.org/10.1016/j.ajoms.2017.11.008.

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11

Liu, Haitao, Jinlin Jia, Xuemei Mao, and Zhiyong Lin. "Association of CYP1A1 and GSTM1 Polymorphisms With Oral Cancer Susceptibility." Medicine 94, no. 27 (2015): e895. http://dx.doi.org/10.1097/md.0000000000000895.

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12

Zhao, Su-Feng, Xu-Dong Yang, Ming-Xing Lu, et al. "GSTM1 null polymorphisms and oral cancer risk: a meta-analysis." Tumor Biology 35, no. 1 (2013): 287–93. http://dx.doi.org/10.1007/s13277-013-1037-z.

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13

Chatterjee, Sumana, Soujatya Dhar, Bani Sengupta, et al. "Polymorphisms of CYP1A1, GSTM1 and GSTT1 Loci as the Genetic Predispositions of Oral Cancers and Other Oral Pathologies: Tobacco and Alcohol as Risk Modifiers." Indian Journal of Clinical Biochemistry 25, no. 3 (2010): 260–72. http://dx.doi.org/10.1007/s12291-010-0057-3.

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14

Cha, In-Ho, Jong Yun Park, Won-Yoon Chung, Min-Ah Choi, Hyung-Jun Kim, and Kwang-Kyun Park. "Polymorphisms of CYP1A1 and GSTM1 Genes and Susceptibility to Oral Cancer." Yonsei Medical Journal 48, no. 2 (2007): 233. http://dx.doi.org/10.3349/ymj.2007.48.2.233.

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Abraham, M. T., L. P. Karen-Ng, W. M. N. Ghani, R. B. Zain, R. J. Raja-Latifah, and S. C. Cheong. "P3.56. CYP1A1, GSTM1 and GSTT1 polymorphisms and oral cancer – Correlation with patients’ status at 2-year, age of onset, nodal status, tumor size and stage." Oral Oncology Supplement 3, no. 1 (2009): 219–20. http://dx.doi.org/10.1016/j.oos.2009.06.582.

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16

Zhang, Z. J., K. Hao, R. Shi, et al. "Glutathione S-Transferase M1 (GSTM1) and Glutathione S-Transferase T1 (GSTT1) Null Polymorphisms, Smoking, and Their Interaction in Oral Cancer: A HuGE Review and Meta-Analysis." American Journal of Epidemiology 173, no. 8 (2011): 847–57. http://dx.doi.org/10.1093/aje/kwq480.

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17

Shukla, Deepika, Alka Dinesh Kale, Seema Hallikerimath, Venkatakanthaiah Yerramalla, Vivekanandhan Subbiah, and Shashwat Mishra. "Association between GSTM1 and CYP1A1 polymorphisms and survival in oral cancer patients." Biomedical Papers 157, no. 4 (2013): 304–10. http://dx.doi.org/10.5507/bp.2013.028.

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18

CARRICA, VICTIRUANO ANDRES, IRAZUZTA GRACIANA, UNAMUNO VICTORIA, et al. "CARCINOGEN-RELATED CYP1A1 AND GSTM1 GENETIC POLYMORPHISMS IN ORAL CANCER AND ORAL POTENTIALLY MALIGNANT DISORDERS." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 129, no. 1 (2020): e154. http://dx.doi.org/10.1016/j.oooo.2019.06.661.

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19

Zhuo, Wenlei, Yan Wang, Xianlu Zhuo, et al. "CYP1A1 and GSTM1 Polymorphisms and Oral Cancer Risk: Association Studies Via Evidence-Based Meta-Analyses." Cancer Investigation 27, no. 1 (2009): 86–95. http://dx.doi.org/10.1080/07357900802146170.

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Mahimkar, Manoj B., Tanuja A. Samant, Sadhana Kannan, Jatin Tulsulkar, Prathamesh S. Pai, and Devasena Anantharaman. "Polymorphisms in GSTM1 and XPD genes predict clinical outcome in advanced oral cancer patients treated with postoperative radiotherapy." Molecular Carcinogenesis 51, S1 (2011): E94—E103. http://dx.doi.org/10.1002/mc.21868.

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21

Yadav, Binod Kumar, Jatinder Kaur, Anurag Srivastava, and Ranju Ralhan. "Effect of polymorphisms in XRCC1, CCND1 and GSTM1 and tobacco exposure as risk modifier for oral leukoplakia." International Journal of Biological Markers 24, no. 2 (2009): 90–98. http://dx.doi.org/10.5301/jbm.2009.5376.

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Karen-Ng, L. P., W. M. N. Ghani, A. Vimmitra, et al. "O46. Aldehyde dehydrogenase 2 (ALDH2) and glutathione S-transferase M1 (GSTM1) polymorphisms in relation to oral cancer risk among Malaysians." Oral Oncology 47 (July 2011): S43—S44. http://dx.doi.org/10.1016/j.oraloncology.2011.06.157.

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23

Olivieri, Eloisa Helena Ribeiro, Sabrina Daniela da Silva, Fernando Fernandes Mendonça, et al. "CYP1A2*1C, CYP2E1*5B, and GSTM1 polymorphisms are predictors of risk and poor outcome in head and neck squamous cell carcinoma patients." Oral Oncology 45, no. 9 (2009): e73-e79. http://dx.doi.org/10.1016/j.oraloncology.2009.03.004.

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24

Patel, Shiv Kumar, and Mitashree Mitra. "Inter-Gene and Gene - Environment Interactions Associated with CYP1A1 and GSTM1 Gene Polymorphisms and Risk of Oral Cancer in Chhattisgarh Population, India." Asian Man (The) - An International Journal 6, no. 2 (2012): 135. http://dx.doi.org/10.5958/j.0975-6884.6.2.005.

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25

Chatterjee, A., A. Banerjee, P. Yadav, et al. "AA Homozygous Genotype of GSTP1 I105V Polymorphism in Oral Cancer: In Silico Screening, Molecular Dynamics Simulation and Activity Studies of Wild and Mutant GSTP1." Journal of Global Oncology 4, Supplement 2 (2018): 42s. http://dx.doi.org/10.1200/jgo.18.33900.

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Background: Highest incidence of oral squamous cell carcinoma (OSCC) has been reported in north-eastern India and causal association between cancer and raw areca-nut (RAN) consumption are well evident. Earlier studies revealed that monitoring the occurrence of precocious anaphase and expression of securin in blood lymphocytes can be a good biomarkers for cancer risk in RAN+lime chewers. Glutathione S-transferases (GSTs) are considered an important cellular detoxification system that provide protection against the effects of toxins and determine individual's cancer susceptibility. Aim: Although

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Chen, Han-chun, Yan-fei Cao, Wei-xin Hu, et al. "Genetic Polymorphisms of Phase II Metabolic Enzymes and Lung Cancer Susceptibility in a Population of Central South China." Disease Markers 22, no. 3 (2006): 141–52. http://dx.doi.org/10.1155/2006/436497.

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A case-control study was conducted for analyzing the genetic polymorphisms of phase II metabolic enzymes in 97 patients with lung cancer and 197 healthy subjects from Han ethnic group of Hunan Province located in Central South China. The results showed that the frequencies of glutathione S-transferase (GST) M1-null (GSTM1-) or GSTT1-null (GSTT1-) genotype alone, or combined form of both in lung cancer patients were significantly higher than those of the controls. Genotypes of combining GSTP1 mutant/GSTM1(-) or GSTP1 mutant/GSTT1(-) led to high risk of lung cancer. Individuals carrying any two

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Duarte, Eliza Carla Barroso, Marina Sena Lopes Silva, Marcus Vinicius Gomez, and Ricardo Santiago Gomez. "GSTM1 polymorphism and oral leukoplakia." Journal of Oral Pathology and Medicine 35, no. 4 (2006): 202–5. http://dx.doi.org/10.1111/j.1600-0714.2006.00405.x.

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28

Aguiar, Ernestina Silva de, Juliana Giacomazzi, Aishameriane Venes Schmidt, et al. "GSTM1, GSTT1, and GSTP1 polymorphisms, breast cancer risk factors and mammographic density in women submitted to breast cancer screening." Revista Brasileira de Epidemiologia 15, no. 2 (2012): 246–55. http://dx.doi.org/10.1590/s1415-790x2012000200002.

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Genetic polymorphisms in genes related to the metabolism of xenobiotics, such as genes of the glutathione S-transferases (GSTM1, GSTT1, and GSTP1) superfamily have been associated with an increased risk for breast cancer (BC). Considering the high incidence of BC in the city of Porto Alegre in southern Brazil, the purpose of this study was to characterize genotypic and allelic frequencies of polymorphisms in GSTM1, GSTT1, and GSTP1, and correlate these molecular findings with established risk factors for breast cancer including mammographic density, in a sample of 750 asymptomatic women underg

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Liu, Chunmei, Yan Zeng, Xizhen Ma, et al. "An Updated Meta-Analysis: Cervical Cancer Risk Conferred by GSTM1 and GSTT1 Polymorphisms." International Journal of Sciences Volume 6, no. 2017-01 (2017): 52–63. https://doi.org/10.5281/zenodo.3349335.

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Objective: To study the influence of GSTM1 and GSTT1 gene polymorphisms on cervical cancer (CC) risk, and explore genetic-environmental interactions. Methods: After a systematic literature search, all relevant studies entailing the association between GST polymorphisms and CC were included. The pooled odds ratio (OR) was used for analysis of the results and corresponding 95% confidence intervals (CI) were estimated. Results: A total of 23 case-control studies were included in the meta-analysis of GSTM1 (2,250 CC cases and 3,025 controls) and GSTT1 (1,704 CC cases and 2,460 controls) genotypes.

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Drummond, Sérgio Neves, Luiz De Marco, Júlio Carlos Motta Noronha, and Ricardo Santiago Gomez. "GSTM1 polymorphism and oral squamous cell carcinoma." Oral Oncology 40, no. 1 (2004): 52–55. http://dx.doi.org/10.1016/s1368-8375(03)00132-5.

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31

Hireche, Ahmed, Naouel Chaoui Kherouatou, Asma Ribouh, Noureldine Abadi, Ming Jun Shi, and Dalila Satta. "POLYMORPHIC DELETIONS OF GLUTATHIONE S-TRANSFERASES M1, T1 AND BLADDER CANCER RISK IN ALGERIAN POPULATION." Asian Journal of Pharmaceutical and Clinical Research 11, no. 5 (2018): 458. http://dx.doi.org/10.22159/ajpcr.2018.v11i5.25673.

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Objective: Glutathione S-transferase mu 1 (GSTM1) and GST theta 1 (GSTT1) genes are two xenobiotic metabolizing genes in Phase II of the detoxification process. The polymorphisms of GSTM1, GSTT1 genes, and smoking are involved in many cancers such as bladder cancer. Our aim was to assess the role of smoking status and GSTM1 and GSTT1 null genotypes in bladder cancer development in Algerian population.Methods: The current case–control study included 175 bladder cancer patients and 188 controls matched for age, gender, and ethnic origin. The GSTM1 and GSTT1 genotypes were determined by multiplex

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Almeida, Micaela, Mafalda Soares, José Fonseca-Moutinho, Ana Cristina Ramalhinho, and Luiza Breitenfeld. "Influence of Estrogenic Metabolic Pathway Genes Polymorphisms on Postmenopausal Breast Cancer Risk." Pharmaceuticals 14, no. 2 (2021): 94. http://dx.doi.org/10.3390/ph14020094.

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Estrogen metabolism plays an important role in tumor initiation and development. Lifetime exposure to high estrogens levels and deregulation of enzymes involved in estrogen biosynthetic and metabolic pathway are considered risk factors for breast cancer. The present study aimed to evaluate the impact of mutations acquisition during the lifetime in low penetrance genes that codify enzymes responsible for estrogen detoxification. Genotype analysis of GSTM1 and GSTT1 null polymorphisms, CYP1B1 Val432Leu and MTHFR C677T polymorphisms was performed in 157 samples of women with hormone-dependent bre

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Sánchez-Siles, Mariano, Juan Pablo Pelegrín-Hernández, Diego Hellin-Meseguer, et al. "Genotype of Null Polymorphisms in Genes GSTM1, GSTT1, CYP1A1, and CYP1A1*2A (rs4646903 T>C)/CYP1A1*2C (rs1048943 A>G) in Patients with Larynx Cancer in Southeast Spain." Cancers 12, no. 9 (2020): 2478. http://dx.doi.org/10.3390/cancers12092478.

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Background: some types of cancer have been associated with the presence of single nucleotide polymorphisms (SNPs) of some genes that encode enzymes: glutathione-S transferase (GST), whose alteration leads to loss of function and a lower capacity to eliminate toxic GSTM1 and GSTT1 null genotypes; SNPs causing loss of function of CYP1A1 or CYP1A1–2 cytochrome P450 enzymes related with a lower capacity to deactivate hydrocarbons related to smoking, which involves a higher risk of developing some smoking-dependent cancers including larynx cancer. Objective: to compare the presence of null SNPs in

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Alexandrie, Anna-Karin, Fredrik Nyberg, Margareta Warholm, and Agneta Rannug. "Influence of CYP1A1, GSTM1, GSTT1, and NQO1 Genotypes and Cumulative Smoking Dose on Lung Cancer Risk in a Swedish Population." Cancer Epidemiology, Biomarkers & Prevention 13, no. 6 (2004): 908–14. http://dx.doi.org/10.1158/1055-9965.908.13.6.

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Abstract The major identified risk factor for lung cancer is tobacco smoking. We identified previously the possible modifying influence of CYP1A1 and GSTM1 polymorphisms on lung cancer risk in a Swedish population. The present study, extended by several study subjects and with analyses for polymorphisms in GSTT1 and NQO1, includes 524 lung cancer cases and 530 control subjects. No evidence for an influence of genetic polymorphisms in CYP1A1, GSTM1, GSTT1, and NQO1 on lung cancer risk overall was found. In smokers, there was, however, a suggestion that the variant CYP1A1 and NQO1 genotypes may

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Aguiar, E., J. Giacomazzi, E. I. Palmero, et al. "Null allele polymorphisms in the GSTT1 and GSTM1 genes in 705 women from a mammographic breast cancer screening program (NMPOA) in southern Brazil." Journal of Clinical Oncology 25, no. 18_suppl (2007): 21091. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.21091.

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21091 Background: Several genetic polymorphisms in genes related with metabolism have been associated with breast cancer (BC) risk. Among these, the gluthatione-S-transferase M1 and T1 null genotypes have been associated with slightly increased BC risk in some populations. In Brazil, BC is a significant public health problem, due to its high incidence and mortality rates. In Porto Alegre, Brazil`s southernmost capital, a multidisciplinary BC Prevention Project - the Nucleo Mama Porto Alegre Cohort (NMPOA)- was started in 2004 and includes a mammographic screening program for women ages 40–69 y

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Moawia, S., M. Elbordiny, and A. Saad. "Glutathione S-transferase T1, M1 genetic polymorphisms in cases of acute leukemia." Journal of Clinical Oncology 25, no. 18_suppl (2007): 7053. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.7053.

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7053 Background: Glutathione S-transferases (GSTs) are enzymes that detoxify potentially mutagenic and carcinogenic xenobiotics. The genes encoding isoenzymes M1 and T1 are polymorphic in humans and the phenotypic absence of enzyme activity is caused by a homozygous inherited deletion of the gene. The null genotype has been associated with incidence of several types of solid tumors. In addition, GSTM1 and GSTT1 polymorphisms have been considered as risk factors for developing acute leukemia in a number of studies; however the overall results of these previous reports are inconsistent and even

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Saad, A. A., P. J. O'Connor, M. H. Mostafa, et al. "Glutathione S-Transferase M1, T1 and P1 Polymorphisms and Bladder Cancer Risk in Egyptians." International Journal of Biological Markers 20, no. 1 (2005): 69–72. http://dx.doi.org/10.1177/172460080502000111.

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Previous studies suggest that bladder cancer risk may vary with GST genotype but these results are inconsistent. The aim of this study was to explore whether GSTM1, GSTT1 and GSTP polymorphisms were associated with increased bladder cancer risk in an Egyptian population. GSTM1, GSTT1 and GSTP1 genotype frequencies were determined in bladder cancer cases (n=72) and healthy controls with no history of malignancies (n=82) using PCR-based techniques. The GSTT1*2 genotype was particularly associated with increased risk (OR 2.71, 95%CI 1.27–5.73) and the GSTM1*2 genotype to a lesser extent (OR 1.63,

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Costa, Ana Carolina Messias de Souza Ferreira da, Marcela Brennand Pina Moreira, Amina Kadja Martins Cahú, et al. "Null polymorphism of the GSTM1 and GSTT1 genes in susceptibility to colorectal tumorigenesis: systematic review with meta-analysis." Caderno Pedagógico 21, no. 9 (2024): e7360. http://dx.doi.org/10.54033/cadpedv21n9-008.

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Objective: To assess if GSTT1 and GSTM1 null polymorphisms increase susceptibility to colorectal cancer. Methods: A search was conducted in PubMed, SciELO, BVS, and Medline databases. Forty articles were selected, totaling 12,698 cases and 19,517 controls. Odds ratios with 95% confidence intervals were used, and p-values <0.05 were considered significant. The Dersimonian-Laird method was applied for p-values <0.05, and the Mantel-Haenszel method was used otherwise. All p-values were two-tailed with an alpha value of 0.05 determined a priori. STATA 16.0 software was utilized. Result: A hi

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Skulskaya, S. V., T. G. Verbickaya та S. A. Shnajder. "PROBABILITY OF DENTAL PATHOLOGY DEVELOPMENT IN CHILDREN RESIDING IN ZONES OF VARIOUS ANTHROPOGENIC LOADS BASED ON MOLECULAR GENETIC EVALUATION OF POLYMORPHISMS OF І AND ІІ PHASE OF DETOXICATION". EurasianUnionScientists 3, № 3(72) (2020): 37–41. http://dx.doi.org/10.31618/esu.2413-9335.2020.3.72.637.

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Relevance. Adverse environmental conditions and man-made disasters are not considered as air, soil and groundwater oversaturated environmental pollutants and toxicants. They cause disturbances in biochemical reactions and metabolic processes in childhood and at a young age. The aim of this study was to determine the effect of polymorphism of the detoxification gene of the first phase Cyp1A1 (A1506G) and the second phase genes GSTM1, GSTT1, on hard tissue indices of permanent teeth, periodontal indices and oral hygiene indices in children living in areas of different anthropogenic stress. Mater

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Ha, Yun-Sok, Chunri Yan, Min Su Lym, et al. "GSTT1as a Prognosticator for Recurrence and Progression in Patients with Non-Muscle-Invasive Bladder Cancer." Disease Markers 29, no. 2 (2010): 81–87. http://dx.doi.org/10.1155/2010/816149.

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Although polymorphisms in glutathione S-transferase (GST) have been associated with the risk of bladder cancer (BC), few reports provide information about the development of BC. The aim of the present study was to investigate the effect of homozygous glutathione S-transferase-μ (GSTM1) and glutathione S-transferase-&phis; (GSTT1) deletions as prognostic markers in non-muscle-invasive bladder cancer (NMIBC). A total of 241 patients with primary NMIBC were enrolled in this study. GSTM1 and GSTT1 polymorphisms were analyzed by multiplex polymerase chain reaction (PCR) using blood genomic DNA.

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41

Kim, Sung-Doo, Je-Hwan Lee, Seong-Gil Ryu, et al. "Influence of Glutathione S-Transferase (GST) Gene Polymorphisms On the Clearance of Intravenous Busulfan in Adult Patients Undergoing Hematopoietic Cell Transplantation." Blood 114, no. 22 (2009): 1179. http://dx.doi.org/10.1182/blood.v114.22.1179.1179.

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Abstract Abstract 1179 Poster Board I-201 Introduction: Intravenous (iv) busulfan can yield a more consistent dosing and pharmacokinetic profile than oral formulation, but there is still inter-patient variability in systemic exposure with iv busulfan. GST gene polymorphisms may explain the variability because busulfan is metabolized in liver through conjugation with GST family. Thus, we investigated the influence of polymorphisms of 3 GST genes, GSTA1, GSTM1, and GSTT1 on the clearance of iv busulfan in adult patients undergoing hematopoietic cell transplantation (HCT). Patients and Methods: W

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Economopoulos, Konstantinos P., Theodoros N. Sergentanis, and Nikos F. Vlahos. "Glutathione S-transferase M1, T1, and P1 Polymorphisms and Ovarian Cancer Risk: A Meta-Analysis." International Journal of Gynecologic Cancer 20, no. 5 (2010): 732–37. http://dx.doi.org/10.1111/igc.0b013e3181dedeb5.

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Introduction:Cytosolic glutathione S-transferase (GST) comprises multiple isoenzymes that catalyze reactions between glutathione and lipophilic compounds with electrophilic centers, resulting in the neutralization of toxic compounds, xenobiotics, and products of oxidative stress. Several studies have examined whether GST polymorphisms (GSTM1 null/present genotype, GSTT1 null/present genotype, and GSTP1 Ile105Val) represent risk factors for ovarian cancer, as they all may denote reduced enzyme activity. This meta-analysis aimed to examine the associations between the aforementioned polymorphism

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Davies, Stella M., Leslie L. Robison, Jonathan D. Buckley, et al. "Glutathione S-Transferase Polymorphisms and Outcome of Chemotherapy in Childhood Acute Myeloid Leukemia." Journal of Clinical Oncology 19, no. 5 (2001): 1279–87. http://dx.doi.org/10.1200/jco.2001.19.5.1279.

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PURPOSE: Glutathione S-transferase theta (GSTT1) and mu (GSTM1) genes are polymorphic, the genes being absent in approximately 15% and 50% of the population, respectively. Because glutathione S-transferases may be involved in the metabolism of chemotherapy drugs, we hypothesized that presence or absence of the genes may influence the outcome of treatment for childhood acute myeloid leukemia (AML). PATIENTS AND METHODS: We genotyped GSTT1 and GSTM1 in 306 children with AML receiving chemotherapy on Children’s Cancer Group therapeutic studies. Outcomes were compared in those with and without GST

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Trujillo-Paolillo, Alini, Carolina Salinas-Souza, Indhira Dias-Oliveira, Antonio Sergio Petrilli, and Silvia R. C. Toledo. "Role of glutathione S-transferase and cytochrome P-450 polymorphisms in the clinical outcome of osteosarcoma patients." Journal of Clinical Oncology 31, no. 15_suppl (2013): 10535. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.10535.

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10535 Background: Osteosarcoma (OS) is the most common malignant bone tumor in children and adolescents. Glutathione S-transferase (GST) and Cytochrome P-450 (CYP) family genes are involved in almost all anticancer drugs metabolism. The polymorphisms in these genes are associated with anticancer drugs resistance and toxicity events. This study aims to investigate the genotype frequencies of GSTM1, GSTT1, GSTM3, CYP1A2, CYP2C9 and CYP3A5 genes in OS patients and the influence of these polymorphisms in their clinical outcome. Methods: We investigated the peripheral blood DNA of 70 OS patients (2

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Isakova, Zh, Vyacheslav Kipen, K. Aytbaev, et al. "POLYMORPHISMS IN GSTM1, GSTP1 AND GSTT1 GENES AND BREAST CANCER RISK IN WOMEN FROM KYRGYZSTAN." Problems in oncology 66, no. 5 (2020): 514–23. http://dx.doi.org/10.37469/0507-3758-2020-66-5-514-523.

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Aim: We studied the intergenic interactions and the contribution of polymorphic loci for GSTT1, GSTM1, GSTP1 genes in the formation of predisposition to breast cancer (ВС) in women of Kyrgyz nationality. Material and method: The study included 87 women of the Kyrgyz ethnic group with the morphologically verified diagnosis of BC and 96 women without cancer and chronic diseases. Genotyping of single-nucleotide polymorphisms (SNPs) was performed using PCR-RFLP for rs1695 GSTP1 gene. Deletion polymophisms in GSTT1 and GSTM1 genes were determined using allele-specific real-time PCR. Analysis of the

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Milosevic-Djordjevic, Olivera, Darko Grujicic, Marina Radovic-Jakovljevic, et al. "Influence of GSTT1 and GSTM1 null genotypes on differentiated thyroid cancer risk and baseline and radioiodine induced cytogenetic damage in peripheral blood lymphocytes of patients." Genetika 49, no. 2 (2017): 599–611. http://dx.doi.org/10.2298/gensr1702599m.

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As it is known that genetic polymorphisms of glutathione S-transferases (GST) have been associated with a variety of human diseases including cancer, we have analyzed the impact of GSTT1 and GSTM1 null genotypes on the risk of development of differentiated thyroid cancer (DTC) and cytogenetic changes in peripheral blood lymphocytes of DTC patients before and after radioiodine therapy. The polymorphism of GSTT1 and GSTM1 genes were genotyped using multiplex polymerase chain reaction (PCR) and cytokinesis - block micronucleus (MN) assay to assess cytogenetic changes. GSTT1 and GSTM1 null were pr

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Diakite, Brehima, Yaya Kassogue, Mamoudou Maïga, et al. "Abstract 6833: Influence of guthation S transferase T1 and M1 polymorphisms on tamoxifen metabolism in malian women with breast cancer." Cancer Research 85, no. 8_Supplement_1 (2025): 6833. https://doi.org/10.1158/1538-7445.am2025-6833.

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Abstract Background: The metabolism of tamoxifen, used in breast cancer treatment, is influenced by the GSTT1 and GSTM1 genes. Women were classified as poor (inactivated genes), intermediate (reduced enzyme activity), or rapid (functional genes) metabolizers. This classification helped to understand how genetic variations affected treatment efficacy and side effect risk, promoting a personalized therapeutic approach. This study aimed to analyze the impact of GSTT1 and GSTM1 genetic variations on tamoxifen metabolism in Malian women with breast cancer. Methods: A cohort study was conducted invo

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Gronau, S., D. Koenig-Greger, M. Jerg, and H. Riechelmann. "Gene Polymorphisms in Detoxification Enzymes as Susceptibility Factor for Head and Neck Cancer?" Otolaryngology–Head and Neck Surgery 128, no. 5 (2003): 674–80. http://dx.doi.org/10.1016/s0194-59980300176-1.

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OBJECTIVE: Impaired detoxification of carcinogens found in tobacco smoke appears to increase the risk for tobacco associated cancer. The objective of this study was to investigate concomitant polymorphisms in genes encoding for various detoxification enzymes in patients with head and neck squamous cell carcinoma (HNSCC). METHODS: In 187 patients with HNSCC and in 139 healthy control subjects, the polymorphisms of cytochrome P450 1A1 ( CYP1A1), cytochrome P450 2D6 ( CYP2D6), and glutathione S-transferase μ1 and θ ( GSTM1, GSTT1) were detected by polymerase chain reaction. RESULTS: No significan

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DeMichele, Angela, Richard Aplenc, Jeffrey Botbyl, et al. "Drug-Metabolizing Enzyme Polymorphisms Predict Clinical Outcome in a Node-Positive Breast Cancer Cohort." Journal of Clinical Oncology 23, no. 24 (2005): 5552–59. http://dx.doi.org/10.1200/jco.2005.06.208.

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Purpose Adjuvant chemotherapy cures only a subset of women with nonmetastatic breast cancer. Genotypes in drug-metabolizing enzymes, including functional polymorphisms in cytochrome P450 (CYP) and glutathione S-transferases (GST), may predict treatment-related outcomes. Patients and Methods We examined CYP3A4*1B, CYP3A5*3, and deletions in GST μ (GSTM1) and θ (GSTT1), as well as a priori–defined combinations of polymorphisms in these genes. Using a cohort of 90 node-positive breast cancer patients who received anthracycline-based adjuvant chemotherapy followed by high-dose multiagent chemother

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Sahoo, Pranab Kumar, Tanuma Mistry, SUSHMITA GHOSH, et al. "Clinical implications of drug-metabolizing genes CYP3A4 and GSTP1 single nucleotide polymorphisms in oral cancer patients undergoing induction chemotherapy." JCO Global Oncology 9, Supplement_1 (2023): 95. http://dx.doi.org/10.1200/go.2023.9.supplement_1.95.

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95 Background: Despite well-established induction chemotherapeutics for advanced-stage oral cavity cancer (OCC), there are no reliable markers to detect drug-induced toxicity and clinical efficacy. The presence of genetic polymorphisms can cause certain enzymes to behave differently in various populations, which can lead to varied outcomes. Thus, we analyzed the effect of metabolizing (CYP3A4) and detoxifying (GSTP1) genes involved in taxane/platinum/5-fluorouracil (TPF) or paclitaxel/carboplatin (PC) metabolism and their clinical outcomes in OCC patients. Methods: The current study included 1

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