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Journal articles on the topic 'GSTPi'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Paret, Aurelie, Delphine Rolland, Vincent Ribrag, Bertrand Coiffier, and Catherine Thieblemont. "Inhibition of GSTpi Activity Increases the Sensitivity of MCL Cell Lines to Cisplatin, Cytarabin and Bortezomib, but Not Doxorubicin." Blood 106, no. 11 (2005): 2806. http://dx.doi.org/10.1182/blood.v106.11.2806.2806.

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Abstract Preliminary data suggest drug resistance plays a major role in mantle cell lymphoma (MCL) and is linked to the aberrant expression of molecules such as Glutathion S-Transferase pi (GST pi) that catalyzes the nuclear conjugation of a broad variety of reactive electrophiles to the glutathion. We investigated in vitro the effect of the inhibition of GSTpi activity on the chemosensitivity of MCL cell lines by inhibiting the nuclear transport of GSTpi with Agaricus bisporus leptine (ABL). Methods. Four MCL cell lines (Granta, NCEB, REC and UPN1) were analyzed for GSTP1 transcript expressio

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Veropotvelyan, P. N., I. S. Tsehmistrenko, N. P. Veropotvelyan, N. S. Rusak, and M. S. Pivnev. "The importance and significance of gene polymorphisms in preeclampsia." HEALTH OF WOMAN, no. 8(114) (October 30, 2016): 45–49. http://dx.doi.org/10.15574/hw.2016.114.45.

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Was to conduct a systematic review of data on the relationship between polymorphisms genes of detoxification system and development of preeclampsia (РЕ). Рresents the main genes of detoxification system (GSTPI, GSTМI, GSTТI, GРХI, ЕРНХI, SOD-2, SOD-3, CYPIAL, MTHЕR, MTR) and their functions. Of interest is the possibility of calculating the individual risk of PE based on the results about the presence of a combination of different polymorphisms in the genotype of the female. Question about early diagnosis of РЕ remains controversial and not fully understood. It is necessary to conduct further

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Yang, Yang, Fangyuan Yin, Qiyun Hang, et al. "Regulation of Endothelial Permeability by Glutathione S-Transferase Pi Against Actin Polymerization." Cellular Physiology and Biochemistry 45, no. 1 (2018): 406–18. http://dx.doi.org/10.1159/000486918.

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Background/Aims: Inflammation-induced injury of the endothelial barrier occurs in several pathological conditions, including atherosclerosis, ischemia, and sepsis. Endothelial cytoskeleton rearrangement is an important pathological mechanism by which inflammatory stimulation triggers an increase of vascular endothelial permeability. However, the mechanism maintaining endothelial cell barrier function against inflammatory stress is not fully understood. Glutathione S-transferase pi (GSTpi) exists in various types of cells and protects them against different stresses. In our previous study, GSTp

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Ruzzo, Annamaria, Francesco Graziano, Kazuyuki Kawakami, et al. "Pharmacogenetic Profiling and Clinical Outcome of Patients With Advanced Gastric Cancer Treated With Palliative Chemotherapy." Journal of Clinical Oncology 24, no. 12 (2006): 1883–91. http://dx.doi.org/10.1200/jco.2005.04.8322.

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Purpose To investigate whether polymorphisms with putative influence on fluorouracil/cisplatin activity are associated with clinical outcomes of patients with advanced gastric cancer (AGC). Patients and Methods Peripheral blood samples from 175 prospectively enrolled AGC patients treated with fluorouracil/cisplatin palliative chemotherapy were used for genotyping 13 polymorphisms in nine genes (TS, MTHFR, XPD, ERCC1, XRCC1, XRCC3, GSTPI, GSTTI, GSTMI). Genotypes were correlated to response and survival. Results The overall response rate was 41%, the median progression-free survival (PFS) was 2

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Zhang, Guowei, Xing Zeng, Caixia Li, et al. "Inhibition of Urinary Bladder Carcinogenesis by Aqueous Extract of Sclerotia of Polyporus umbellatus Fries and Polyporus Polysaccharide." American Journal of Chinese Medicine 39, no. 01 (2011): 135–44. http://dx.doi.org/10.1142/s0192415x11008701.

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The study aimed to evaluate inhibition effect of sclerotia of Polyporus umbellatus Fries aqueous extract (SPUE) and polyporus polysaccharide (PPS) on bladder cancer, then to measure their effect on mRNA expression of glutathione S-transferase π (GSTPi) and NAD(P)H:quinone oxidoreductase 1 (NQO1) in female Fischer-344 rats model. The model rats were induced by N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) for a period of 8 weeks and saccharin for 12 weeks. SPUE (50 mg/kg, 250 mg/kg, 500 mg/kg) and PPS (28 mg/kg) were orally administrated to the model rats during the whole study. Compared to the

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Gerardi, Daniel G., Mirela Tinucci-Costa, Ana Carolina T. Silveira, and Juliana V. Moro. "Expression of P-glycoprotein, multidrug resistance-associated protein, glutathione-S-transferase pi and p53 in canine transmissible venereal tumor." Pesquisa Veterinária Brasileira 34, no. 1 (2014): 71–78. http://dx.doi.org/10.1590/s0100-736x2014000100012.

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The overexpression of proteins P-glycoprotein (P-gp), multidrug resistance-associated protein (MRP1), mutant p53, and the enzyme glutathione-S-transferase (GSTpi) are related to resistance to chemotherapy in neoplasms. This study evaluated the expression of these markers by immunohistochemistry in two groups of canine TVT, without history of prior chemotherapy (TVT1, n=9) and in TVTs presented unsatisfactory clinical response to vincristine sulfate (TVT2, n=5). The percentage of specimens positively stained for P-gp, MRP1, GSTpi and p53 were, respectively 88.8%, 0%, 44.5% and 22.2% in TVT1 and

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7

SUNDBERG, Kathrin, Bengt JERNSTRÖM, and Stellan SWEDMARK. "Studies on the differential inhibition of glutathione conjugate formation of (+)-anti-benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide and 1-chloro-2,4-dinitrobenzene in V79 Chinese hamster cells." Biochemical Journal 349, no. 3 (2000): 693–96. http://dx.doi.org/10.1042/bj3490693.

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V79 Chinese hamster cells have previously been shown to lack the capacity to detoxify the mutagenic and carcinogenic compound (+)-anti-benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide [(+)-anti-BPDE] by Pi class glutathione transferase (GSTPi)-catalysed conjugation with GSH, although these cells contain such an enzyme [Romert, Dock, Jenssen and Jernström (1989) Carcinogenesis 10, 1701–1707; Swedmark, Romert, Morgenstern and Jenssen (1992) Carcinogenesis 13, 1719–1723; Swedmark and Jenssen (1994) Gene 139, 251–256]. Previous findings also indicate that these results do not depend on an inactive GSTP

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8

Singal, R., L. Navarro, E. Gordian, et al. "Aberrant promoter methylation in serum of prostate cancer patients and controls." Journal of Clinical Oncology 27, no. 15_suppl (2009): e16046-e16046. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e16046.

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e16046 Background: The current screening method for prostate cancer (PC), which is based on prostate specific antigen (PSA) level lacks specificity and sensitivity. Previous studies have reported that increased levels of free circulating DNA (fcDNA) and hypermethylation of genes are associated with several cancers. In this study we evaluated the use of fcDNA level and aberrant promoter methylation of 4 genes in serum as biomarkers for PC. Methods: 89 PC patients, 59 with prostatitis (PT) and 104 with benign prostatic hyperplasia (BPH) were enrolled. Serum DNA was analyzed for methylation of GS

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9

Mittal, Disha, Largee Biswas, and Anita Kamra Verma. "Redox resetting of cisplatin-resistant ovarian cancer cells by cisplatin-encapsulated nanostructured lipid carriers." Nanomedicine 16, no. 12 (2021): 979–95. http://dx.doi.org/10.2217/nnm-2020-0400.

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Aim: To sensitize cisplatin (Cis)-resistant ovarian cancer cells toward Cis using Cis-loaded nanostructured lipid carriers (CisNLCs). Materials & methods: CisNLCs were synthesized and characterized using dynamic light scattering, Fourier transform IR and x-ray diffraction (XRD). Sensitivity of PA-1 and CaOV3 cells to Cis and its biotoxicity were assessed. Further, expression of the Cis-resistance markers GSTPi and ATP7B, and apoptotic markers Bax, Bcl2 and Cas9 were quantified by real-time PCR. Results: The size of synthesized CisNLCs was approximately 179.3 ± 2.32 nm and surface charge wa

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10

Raposo, Catarina, Ana Karolina de Santana Nunes, Rayana Leal de Almeida Luna, Shyrlene Meiry da Rocha Araújo, Maria Alice da Cruz-Höfling, and Christina Alves Peixoto. "Sildenafil (Viagra) Protective Effects on Neuroinflammation: The Role of iNOS/NO System in an Inflammatory Demyelination Model." Mediators of Inflammation 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/321460.

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We recently demonstrated that sildenafil reduces the expression of cytokines, COX-2, and GFAP in a demyelinating model induced in wild-type (WT) mice. Herein, the understandings of the neuroprotective effect of sildenafil and the mediation of iNOS/NO system on inflammatory demyelination induced by cuprizone were investigated. The cerebella of iNOS−/−mice were examined after four weeks of treatment with cuprizone alone or combined with sildenafil. Cuprizone increased GFAP, Iba-1, TNF-α, COX-2, IL-1β, and IFN-γexpression, decreased expression of glutathione S-transferase pi (GSTpi), and damaged

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11

Yang, Yang, Xiaoliang Dong, Shuangning Zheng, et al. "GSTpi regulates VE-cadherin stabilization through promoting S-glutathionylation of Src." Redox Biology 30 (February 2020): 101416. http://dx.doi.org/10.1016/j.redox.2019.101416.

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12

Chaiwun, B., N. Sukhamwang, H. Trakultivakorn, et al. "GSTPi-positive tumour microenvironment-associated fibroblasts are significantly associated with GSTPi-negative cancer cells in paired cases of primary invasive breast cancer and axillary lymph node metastases." British Journal of Cancer 105, no. 8 (2011): 1224–29. http://dx.doi.org/10.1038/bjc.2011.352.

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13

Sohn, Eun Jeong, Min Jea Shin, Dae Won Kim, et al. "PEP-1-GSTpi protein enhanced hippocampal neuronal cell survival after oxidative damage." BMB Reports 49, no. 7 (2016): 382–87. http://dx.doi.org/10.5483/bmbrep.2016.49.7.048.

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14

Xu, X., and P. J. Stambrook. "Two murine GSTpi genes are arranged in tandem and are differentially expressed." Journal of Biological Chemistry 269, no. 48 (1994): 30268–73. http://dx.doi.org/10.1016/s0021-9258(18)43807-0.

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15

Thévenin, Anastasia F., Chati L. Zony, Brian J. Bahnson, and Roberta F. Colman. "GSTpi modulates JNK activity through a direct interaction with JNK substrate, ATF2." Protein Science 20, no. 5 (2011): 834–48. http://dx.doi.org/10.1002/pro.609.

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16

Sarker, Azmal K., Raihan Hussain, Faria Nasreen, et al. "Assessment of Agreement between Gated SPECT Myocardial Perfusion Imaging and Gated SPECT Blood Pool Imaging for Measurement of Left Ventricular Ejection Fraction in Coronary Artery Disease." Bangladesh Journal of Nuclear Medicine 19, no. 2 (2018): 128. http://dx.doi.org/10.3329/bjnm.v19i2.36010.

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<p><strong>Objective: </strong>Quantitative assessment of left ventricular ejection fraction (LVEF) from radionuclide cardiac imaging study has both diagnostic and prognostic value in coronary artery disease (CAD). Gated SPECT blood pool imaging (GSBPI) and gated SPECT myocardial perfusion imaging (GSMPI) are two technically comparable radionuclide methods for non-invasive measurement of LVEF. While the former is a gold standard the latter is popular as it provides a wider array of information. This study was carried out to bridge the lack in the existing body of evidence reg

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Tanoglidi, Anna, Nikolaos Ferakis, Vassilios Samaras, Constantinos Bouropoulos, Calypso Barbatis, and Iraklis Poulias. "AN IMMUNOHISTOCHEMICAL STUDY OF GLUTATHIONE-S-TRANSFERASE (GSTPI) AND P27KIP1 IN PROSTATE CARCINOGENESIS." Journal of Urology 181, no. 4S (2009): 478. http://dx.doi.org/10.1016/s0022-5347(09)61353-7.

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18

Jardim, Bruna Victorasso, Marina Gobbe Moschetta, Gabriela Bottaro Gelaleti, et al. "Glutathione transferase pi (GSTpi) expression in breast cancer: An immunohistochemical and molecular study." Acta Histochemica 114, no. 5 (2012): 510–17. http://dx.doi.org/10.1016/j.acthis.2011.09.005.

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19

Mitsudomi, Tetsuya, Yasuo Iwamoto, Kazuto Nishio, et al. "Biomarker analysis of WJOG4107, a randomized phase II trial of adjuvant chemotherapy with S-1 versus CDDP+S-1 for resected stage II-IIIA non-small cell lung cancer (NSCLC)." Journal of Clinical Oncology 31, no. 15_suppl (2013): 7518. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.7518.

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7518 Background: We conducted a randomized phase II trial for patients with resected stage II-IIIA NSCLC comparing postoperative oral S-1 (80 mg/m2/day for consecutive 2 weeks q3w for 1 year) (S) (N=100) or cisplatin (CDDP) (60 mg/m2 day1) plus oral S-1, (80 mg/m2/day for 2 weeks) q3w for 4 cycles (PS)(N=100). We reported that the disease-free survival rate at 2 years (DFS@2) (95% confidence interval: CI), a primary endpoint, was 66 (55-74) % for S and 58 (48-67)% for PS. Here, we report the preliminary results of preplanned biomarker analysis, a co-primary endpoint, to identify molecules whos

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Castro-Caldas, Margarida, Andreia Neves Carvalho, Isabel Peixeiro, Elsa Rodrigues, Maria Celeste Lechner, and Maria João Gama. "GSTpi Expression in MPTP-Induced Dopaminergic Neurodegeneration of C57BL/6 Mouse Midbrain and Striatum." Journal of Molecular Neuroscience 38, no. 2 (2008): 114–27. http://dx.doi.org/10.1007/s12031-008-9141-z.

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21

Jiao, Y., A. Pani, H. Jang, Y. Dou, J. Smith, and S. Richard. "3.139 ALTERATIONS IN MARKERS OF AGING IN SUBSTANTIA NIGRA OF MICE LACKING GLUTATHIONE S-TRANSFERASE PI (GSTPI)." Parkinsonism & Related Disorders 18 (January 2012): S199. http://dx.doi.org/10.1016/s1353-8020(11)70855-0.

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22

Hung, J. Y., J. S. Cheng, S. Ralph, J. English, V. Ling, and S. Lam. "Quantification of MDR1, MRP1, and GSTpi gene expression levels in smokers with and without bronchial dysplasia or cancer." Lung Cancer 29, no. 1 (2000): 198. http://dx.doi.org/10.1016/s0169-5002(00)80672-8.

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23

Yu, D. S., J. C. Lin, D. S. Hsieh, S. Y. Chang, and C. F. Lee. "MODULATION OF MDR-1 GENE BY MIF AND GSTpi WITH DRUG RESISTANCE GENERATION IN HORMONE INDEPENDENT PROSTATE CANCER." Archives of Andrology 52, no. 4 (2006): 283–91. http://dx.doi.org/10.1080/01485010600630116.

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SUZUKI, Takafumi, Yaeko TAKAGI, Hitoshi OSANAI, et al. "Pi class glutathione S-transferase genes are regulated by Nrf 2 through an evolutionarily conserved regulatory element in zebrafish." Biochemical Journal 388, no. 1 (2005): 65–73. http://dx.doi.org/10.1042/bj20041860.

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Pi class GSTs (glutathione S-transferases) are a member of the vertebrate GST family of proteins that catalyse the conjugation of GSH to electrophilic compounds. The expression of Pi class GST genes can be induced by exposure to electrophiles. We demonstrated previously that the transcription factor Nrf 2 (NF-E2 p45-related factor 2) mediates this induction, not only in mammals, but also in fish. In the present study, we have isolated the genomic region of zebrafish containing the genes gstp1 and gstp2. The regulatory regions of zebrafish gstp1 and gstp2 have been examined by GFP (green fluore

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Bohanes, P. O., B. H. Goldman, J. Benedetti, et al. "Association of excision repair cross-complementation group 1 (ERCC1) gene expression (GE) with outcome in stage II-III esophageal adenocarcinoma (EA) patients treated with preoperative platinum-based chemoradiation (CRT) in a phase II cooperative study (SWOG 0356)." Journal of Clinical Oncology 29, no. 4_suppl (2011): 2. http://dx.doi.org/10.1200/jco.2011.29.4_suppl.2.

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2 Background: Preoperative platinum-based CRT for operable esophageal cancer has improved overall survival (OS) compared to surgery alone. The phase II SWOG 0356 trial designed to test oxaliplatin (OXP) plus infusion 5-fluorouracil (5-FU) and external beam radiation prior to surgery for potentially curable EA has produced promising centrally confirmed complete pathologic response (pCR) rate (28.3%). After surgery patients were given a second cycle of OXP and 5FU. 2-year OS was 54.2%. However, treatment efficacy may be significantly compromised as a result of interindividual variations. We test

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CATANI, M. Valeria, Antonio COSTANZO, Isabella SAVINI, et al. "Ascorbate up-regulates MLH1 (Mut L homologue-1) and p73: implications for the cellular response to DNA damage." Biochemical Journal 364, no. 2 (2002): 441–47. http://dx.doi.org/10.1042/bj20011713.

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We have found previously that ascorbic acid (vitamin C), as well as acting as a radical scavenger, may modulate the expression of several genes [i.e. fra-1, glutathione S-transferase Pi (GSTpi) and Mut L homologue-1 (MLH1)] in human keratinocytes. In the present paper, we demonstrate that MLH1, as well as its downstream target p73, can be positively modulated by this antioxidant vitamin, indeed, up-regulation of the two mRNAs was observed after just 2h, and increased further up to 16h of treatment. Modulation of MLH1 and p73 gene expression improves cellular susceptibility to apoptosis trigger

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27

Hoffmann, A. C., J. T. Kaifi, D. Vallböhmer, et al. "Lack of prognostic significance of serum DNA methylation of DAPK, MGMT, and GSTPI in patients with non-small cell lung cancer." Journal of Surgical Oncology 100, no. 5 (2009): 414–17. http://dx.doi.org/10.1002/jso.21348.

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Эрдман, В. В., А. З. Матуа, Т. Р. Насибуллин, et al. "COMPLEX ASSOCIATION ANALYSIS OF ANTIOXIDANT GENES POLYMORPHIC DNA-MARKERS WITH AGE IN THE ETHNIC GROUP OF ABKHAZIANS." Успехи геронтологии, no. 3 (August 2, 2021): 360–66. http://dx.doi.org/10.34922/ae.2021.34.3.004.

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Впервые в этнической группе абхазов выполнен анализ ассоциаций полиморфных ДНК-маркеров генов антиоксидантной системы CAT (rs1001179), MSRA (rs10098474), GPX1 (rs1050450), GSR (rs1002149), GSTP1 (rs1695), SOD1 (rs2070424), SOD2 (rs4880), PON1 (rs662), PON2 (rs7493) с возрастом. С использованием ROC-анализа и логистической регрессии установлено, что спектр частот аллелей и генотипов полиморфных маркеров генов PON1 и GSTP1 меняется на протяжении всего исследуемого возрастного периода (21 107 лет); распределение частот аллелей и генотипов по полиморфным маркерам генов CAT и SOD2 изменяется на руб

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Miao, Jingjing, Luqing Pan, Na Liu, Chaoqun Xu, and Lin Zhang. "Molecular cloning of CYP4 and GSTpi homologues in the scallop Chlamys farreri and its expression in response to Benzo[a]pyrene exposure." Marine Genomics 4, no. 2 (2011): 99–108. http://dx.doi.org/10.1016/j.margen.2011.03.002.

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Kaur, Pavinder, Brenda Ward, Baisakhi Saha, et al. "Human Breast Cancer Histoid." Journal of Histochemistry & Cytochemistry 59, no. 12 (2011): 1087–100. http://dx.doi.org/10.1369/0022155411423680.

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Progress in our understanding of heterotypic cellular interaction in the tumor microenvironment, which is recognized to play major roles in cancer progression, has been hampered due to unavailability of an appropriate in vitro co-culture model. The aim of this study was to generate an in vitro 3-dimensional human breast cancer model, which consists of cancer cells and fibroblasts. Breast cancer cells (UACC-893) and fibroblasts at various densities were co-cultured in a rotating suspension culture system to establish co-culture parameters. Subsequently, UACC-893, BT.20, or MDA.MB.453 were co-cu

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Chen, Dan, Jinjiao Liu, Bing Rui, et al. "GSTpi protects against angiotensin II-induced proliferation and migration of vascular smooth muscle cells by preventing signal transducer and activator of transcription 3 activation." Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1843, no. 2 (2014): 454–63. http://dx.doi.org/10.1016/j.bbamcr.2013.11.024.

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Baranov, Vladislav S. "Ecological genetics and predictive medicine." Ecological genetics 1, no. 1 (2003): 22–29. http://dx.doi.org/10.17816/ecogen1022-29.

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The review highlights present state and some future perspectives of new but quickly expanding area of predictive medicine. Its basic background dealing with molecular testing of genetic polymorphisms as well as its practical and theoretical implications are discussed. Original data concerning the involvement of the genes participating in Phase 1 and Phase 2 of detoxification systems as well as of the genes controlling mineral bone density in the origin, progression and treatment efficiency of some common multifactorial diseases such as endometriosis, bronchial asthma, alcoholic cirrhosis, habi

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Iwasaki, Kenta, Elizabeth L. MacKenzie, Kiros Hailemariam, Kensuke Sakamoto, and Yoshiaki Tsuji. "Hemin-Mediated Regulation of an Antioxidant-Responsive Element of the Human Ferritin H Gene and Role of Ref-1 during Erythroid Differentiation of K562 Cells." Molecular and Cellular Biology 26, no. 7 (2006): 2845–56. http://dx.doi.org/10.1128/mcb.26.7.2845-2856.2006.

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ABSTRACT An effective utilization of intracellular iron is a prerequisite for erythroid differentiation and hemoglobinization. Ferritin, consisting of 24 subunits of H and L, plays a crucial role in iron homeostasis. Here, we have found that the H subunit of the ferritin gene is activated at the transcriptional level during hemin-induced differentiation of K562 human erythroleukemic cells. Transfection of various 5′ regions of the human ferritin H gene fused to a luciferase reporter into K562 cells demonstrated that hemin activates ferritin H transcription through an antioxidant-responsive ele

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Saad, A. A., P. J. O'Connor, M. H. Mostafa, et al. "Glutathione S-Transferase M1, T1 and P1 Polymorphisms and Bladder Cancer Risk in Egyptians." International Journal of Biological Markers 20, no. 1 (2005): 69–72. http://dx.doi.org/10.1177/172460080502000111.

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Previous studies suggest that bladder cancer risk may vary with GST genotype but these results are inconsistent. The aim of this study was to explore whether GSTM1, GSTT1 and GSTP polymorphisms were associated with increased bladder cancer risk in an Egyptian population. GSTM1, GSTT1 and GSTP1 genotype frequencies were determined in bladder cancer cases (n=72) and healthy controls with no history of malignancies (n=82) using PCR-based techniques. The GSTT1*2 genotype was particularly associated with increased risk (OR 2.71, 95%CI 1.27–5.73) and the GSTM1*2 genotype to a lesser extent (OR 1.63,

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Bocedi, Alessio, Annalisa Noce, Giulia Marrone, et al. "Glutathione Transferase P1-1 an Enzyme Useful in Biomedicine and as Biomarker in Clinical Practice and in Environmental Pollution." Nutrients 11, no. 8 (2019): 1741. http://dx.doi.org/10.3390/nu11081741.

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Glutathione transferase P1-1 (GSTP1-1) is expressed in some human tissues and is abundant in mammalian erythrocytes (here termed e-GST). This enzyme is able to detoxify the cell from endogenous and exogenous toxic compounds by using glutathione (GSH) or by acting as a ligandin. This review collects studies that propose GSTP1-1 as a useful biomarker in different fields of application. The most relevant studies are focused on GSTP1-1 as a biosensor to detect blood toxicity in patients affected by kidney diseases. In fact, this detoxifying enzyme is over-expressed in erythrocytes when unusual amo

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Liu, Huan, Xiong Zhou, Shaowen Huang, Jie Yang, Ruijing Liu, and Chunhong Liu. "Lycium Barbarum Polysaccharides and Wolfberry Juice Prevent DEHP-Induced Hepatotoxicity via PXR-Regulated Detoxification Pathway." Molecules 26, no. 4 (2021): 859. http://dx.doi.org/10.3390/molecules26040859.

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Environmental di(2-Ethylhexyl) phthalate (DEHP) is widely used in various industries as a plasticizer, and has been reported to induce reproductive and developmental toxicities in organisms. The purpose of this study was to evaluate the detoxification capacity of Lycium barbarum polysaccharides (LBP) and wolfberry juice (WJ) against DEHP-induced hepatotoxicity. Two groups of rats were purchased to study two different intervention method experiments: LBP (50, 100, 200 mg/kg·bw) intervention before DEHP (2000 mg/kg·bw) exposure, and LBP (200 mg/kg·bw) or WJ (8 mL/kg·bw) intervention after DEHP (

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Zon, Gerald, Melissa A. Barker, Pavinder Kaur та ін. "Formamide as a denaturant for bisulfite conversion of genomic DNA: Bisulfite sequencing of the GSTPi and RARβ2 genes of 43 formalin-fixed paraffin-embedded prostate cancer specimens". Analytical Biochemistry 392, № 2 (2009): 117–25. http://dx.doi.org/10.1016/j.ab.2009.06.001.

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Zarate, R. N., J. Rodriguez, E. Bandres, et al. "Predictive value of Ile105Val polymorphism of the gluthatione-S-transferase P1 in patients with metastatic colorectal cancer (m CRC) treated with the triplet combination of irinotecan, oxaliplatin, and capecitabine." Journal of Clinical Oncology 27, no. 15_suppl (2009): 2544. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.2544.

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2544 Background: Several phase I/II trials have shown that the triplet combination of oxaliplatin, irinotecan and capecitabine is a feasible and active in solid tumors. We aimed to investigate whether germline polymorphisms may be predictors of clinical outcome in mCRC pts treated with this combination. Methods: The following genetic polymorphisms were analysed: glutathione S-transferase (GSTP1-Ile105Val, GSTT1 and GSTM1 deletion), TYMS (TS-5´UTR 2R/3R; TS-5´G/C; TS-3´UTR 6-bp deletion), MTHFR 1298A>C, UGT1A1, ERCC1, XPD. Polymorphisms from peripheral lymphocytes were detected using the Taq

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Raybaud-Diogène, H., A. Fortin, R. Morency, J. Roy, R. A. Monteil, and B. Têtu. "Markers of radioresistance in squamous cell carcinomas of the head and neck: a clinicopathologic and immunohistochemical study." Journal of Clinical Oncology 15, no. 3 (1997): 1030–38. http://dx.doi.org/10.1200/jco.1997.15.3.1030.

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PURPOSE The lack of accurate criteria to predict the response to radiotherapy for individual patients with squamous cell carcinoma of the head and neck (HN-SCC) remains a major problem. The purpose of this study was to investigate the role of several biologic tumor markers to complement clinical prognostic factors in the assessment of response to radiotherapy in SCCs. PATIENTS AND METHODS p53, ki-67, c-erb B-2, heat-shock protein-27 (HSP-27), and glutathione S transferase (GSTpi) were evaluated by immunohistochemistry on biopsies from 101 patients treated for head and neck cancer by radical ra

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Santos, Moema Nene, Vanderson Rocha, Dalila Zanette, et al. "Different Prevalence of Drug Metabolism Gene Polymorphisms (GSTP and GSTT) in FA Patients Compared to a Normal Population." Blood 106, no. 11 (2005): 106. http://dx.doi.org/10.1182/blood.v106.11.106.106.

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Abstract Fanconi Anemia patients have an increased toxicity of drugs used in conditioning regimen (CT) for hematopoietic stem cell transplantation (HSCT), due to defective DNA repair processes. This observation has led to diminish the doses of drugs (such as cyclophosphamide and busulphan) and irradiation in the preparative regimen. We and others have reported that genetic polymorphisms, which interfere with metabolisms of drugs used in CT, are associated with toxicities after HSCT. In order to test the hypothesis that probably Fanconi patients have a difference in prevalence of pharmacogene p

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Butkiewicz, D., K. J. Cole, D. H. Phillips, C. C. Harris, and M. Chorazy. "GSTMI, GSTP1, CYP1A1 and CYP2D6 polymorphisms in lung cancer patients from an environmentally polluted region of Poland." European Journal of Cancer Prevention 8, no. 4 (1999): 315–24. http://dx.doi.org/10.1097/00008469-199908000-00008.

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Rolland, D., S. Gazzo, P. Felman та ін. "Glutathione-S-Transferase π Expression Helps for Differential Diagnosis between Mantle Cell Lymphoma and Marginal Zone Lymphoma with t(11;14)." Blood 104, № 11 (2004): 1364. http://dx.doi.org/10.1182/blood.v104.11.1364.1364.

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Abstract Glutathione-S-transferase π (GSTπ), whose gene is located in 11q13, is belonging to a complex multigene family of enzymes that may detoxify electrophilic xenobiotics. Recent gene expression profiling analysis showed that GSTπ transcript is belonging to the mantle cell lymphoma (MCL) signature and constitutes one of the most expressed mRNA in MCL*. Furthermore it has been reported by immunohistochemistry that overexpression of cyclin D1 in MCL was associated with a high level of GSTπ protein expression. We then looked for the specificity of a high level of GSTπ protein expression in MC

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Howells, R. E. J., K. K. Dhar, P. R. Hoban, et al. "Association between glutathione-S-transferase GSTP1 genotypes, GSTP1 over-expression, and outcome in epithelial ovarian cancer." International Journal of Gynecologic Cancer 14, no. 2 (2004): 242–50. http://dx.doi.org/10.1136/ijgc-00009577-200403000-00010.

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Ovarian cancer accounts for the majority of deaths from gynaecological malignancy, and polymorphisms in genes encoding the glutathione-S-transferase (GST) GSTP1 detoxifying enzymes may lead to variation in detoxification of carcinogens. We describe a study involving 81 women with invasive epithelial ovarian cancer. A number of important clinical variables and outcome data were obtained. GSTP1 genotyping was undertaken using PCR-based techniques, and GSTP1 expression was quantified using immunohistochemistry (IHC). A Cox's proportional hazard regression model was used to analyze the effects on

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RANGANATHAN, Perungavar N., Richard WHALEN, and Thomas D. BOYER. "Characterization of the molecular forms of glutathione S-transferase P1 in human gastric cancer cells (Kato III) and in normal human erythrocytes." Biochemical Journal 386, no. 3 (2005): 525–33. http://dx.doi.org/10.1042/bj20041419.

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GSTP1 (glutathione S-transferase pi) is involved in stress responses and in cellular proliferation pathways as an inhibitor of JNK (c-Jun N-terminal kinase). It has been proposed that monomeric GSTP1 functions as a JNK inhibitor. All of the studies to date have been performed using rodent cells, and it is unclear if monomeric GSTP1 exists in human cells. Monomeric GSTP1 was sought in human gastric cancer cells (Kato III) and in normal human erythrocytes using gel filtration, ELISA and Western blots. Monomeric GSTP1 was found in conditioned medium, in cytosol of Kato III cells and in cytosol of

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Xia, C., J. B. Taylor, S. R. Spencer, and B. Ketterer. "The human glutathione S-transferase P1-1 gene: modulation of expression by retinoic acid and insulin." Biochemical Journal 292, no. 3 (1993): 845–50. http://dx.doi.org/10.1042/bj2920845.

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Glutathione S-transferases (GSTs) are a group of enzymes which play an important role in the detoxication of xenobiotics. It is shown that the expression of human glutathione S-transferase P1-1 (GSTP1-1) is suppressed by retinoic acid (RA) as the result of decreased transcription from its gene, GSTP1. Chloramphenicol acetyltransferase (CAT) assays indicate that the effect of RA on the transcription of a GSTP1 promoter-CAT fusion gene is mediated by the region -99 to +72 of GSTP1. A consensus activator protein 1-binding site, located at nucleotide position -59 to -65 of GSTP1, is suggested to b

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Vidal, Igor, Qizhi Zheng, Jessica L. Hicks, et al. "GSTP1 positive prostatic adenocarcinomas are more common in Black than White men in the United States." PLOS ONE 16, no. 6 (2021): e0241934. http://dx.doi.org/10.1371/journal.pone.0241934.

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GSTP1 is a member of the Glutathione-S-transferase (GST) family silenced by CpG island DNA hypermethylation in 90–95% of prostate cancers. However, prostate cancers expressing GSTP1 have not been well characterized. We used immunohistochemistry against GSTP1 to examine 1673 primary prostatic adenocarcinomas on tissue microarrays (TMAs) with redundant sampling from the index tumor from prostatectomies. GSTP1 protein was positive in at least one TMA core in 7.7% of cases and in all TMA cores in 4.4% of cases. The percentage of adenocarcinomas from Black patients who had any GSTP1 positive TMA co

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Singh, Rahul R., Jiyan Mohammad, Megan Orr, and Katie M. Reindl. "Glutathione S-Transferase pi-1 Knockdown Reduces Pancreatic Ductal Adenocarcinoma Growth by Activating Oxidative Stress Response Pathways." Cancers 12, no. 6 (2020): 1501. http://dx.doi.org/10.3390/cancers12061501.

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Glutathione S-transferase pi-1 (GSTP1) plays an important role in regulating oxidative stress by conjugating glutathione to electrophiles. GSTP1 is overexpressed in breast, colon, lung, and prostate tumors, where it contributes to tumor progression and drug resistance; however, the role of GSTP1 in pancreatic ductal adenocarcinoma (PDAC) is not well understood. Using shRNA, we knocked down GSTP1 expression in three different PDAC cell lines and determined the effect on cell proliferation, cell cycle progression, and reactive oxygen species (ROS) levels. Our results show GSTP1 knockdown reduces

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Chen, Mianzhi, Dan Du, Wen Zheng, et al. "Small hepatitis delta antigen selectively binds to target mRNA in hepatic cells: a potential mechanism by which hepatitis D virus downregulates glutathioneS-transferase P1 and induces liver injury and hepatocarcinogenesis." Biochemistry and Cell Biology 97, no. 2 (2019): 130–39. http://dx.doi.org/10.1139/bcb-2017-0321.

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Liver coinfection by hepatitis B virus (HBV) and hepatitis D virus (HDV) can result in a severe form of hepatocellular carcinoma with poor prognosis. Coinfection with HDV and HBV causes more deleterious effects than infection with HBV alone. Clinical research has shown that glutathione S-transferase P1 (GSTP1), a tumor suppressor gene, is typically downregulated in liver samples from hepatitis-infected patients. In the present study, our data indicated that small HDV antigen (s-HDAg) could specifically bind to GSTP1 mRNA and significantly downregulate GSTP1 protein expression. For the human fe

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Zhou, Li, Yongkui Jing, Miroslav Styblo, Zhu Chen та Samuel Waxman. "Glutathione-S-transferase π inhibits As2O3-induced apoptosis in lymphoma cells: involvement of hydrogen peroxide catabolism". Blood 105, № 3 (2005): 1198–203. http://dx.doi.org/10.1182/blood-2003-12-4299.

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AbstractArsenic trioxide (As2O3) is an effective agent for the treatment of relapsed and refractory acute promyelocytic leukemia by induction of partial differentiation and apoptosis. As2O3, at therapeutic concentrations (1-2 μM), induced apoptosis in Raji lymphoma cells but not in Jurkat lymphoma cells, which inversely correlated with the levels of glutathione-S-transferase π (GSTP1), but not GSTπ1 and GSTM1, expression and activity. GSTP1 mRNA, protein level, and activity were high in Jurkat cells but undetectable in Raji cells. Stable transfection of GSTP1 into Raji cells decreased the amou

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Santric, Veljko, Milica Djokic, Sonja Suvakov, et al. "GSTP1 rs1138272 Polymorphism Affects Prostate Cancer Risk." Medicina 56, no. 3 (2020): 128. http://dx.doi.org/10.3390/medicina56030128.

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Background and Objectives: One of the most frequent genetic alterations reported to date in prostate cancer (PC) is aberrant methylation of glutathione transferase P1 (GSTP1). Taking into consideration the involvement of oxidative stress in PC pathogenesis and recent advances in scientific understanding of the role of GSTP1*Ala114Val rs1138272 polymorphism in carcinogenesis, we hypothesized that this single-nucleotide polymorphism (SNP) influences the risk of PC independently of, or in combination with, other GST polymorphisms, including GSTP1*IIe105Val rs1695 or GSTM1 and GSTT1 deletion polym

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