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Journal articles on the topic 'GSTT1 Polymorphisms'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Pavlovic, Dragana, Sinisa Ristic, Ljubica Djukanovic, et al. "The GSTO2 (rs156697) Polymorphism Modifies Diabetic Nephropathy Risk." Medicina 59, no. 1 (2023): 164. http://dx.doi.org/10.3390/medicina59010164.

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Background and Objectives: In the development of type 2 diabetes mellitus (T2DM) and its complications, genetic and environmental factors play important roles. Diabetic nephropathy (DN), one of the major microangiopathic chronic diabetic complications, is associated with an increased risk of major cardiovascular events and all-cause mortality. The present study was designed to investigate the possible modifying effect of glutathione transferase polymorphisms (GSTM1, GSTT1, GSTP1 rs1138272/rs1695, GSTO1 rs4925 and GSTO2 rs156697) in the susceptibility to T2DM and diabetic nephropathy. Materials

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Kim, Sung-Doo, Je-Hwan Lee, Seong-Gil Ryu, et al. "Influence of Glutathione S-Transferase (GST) Gene Polymorphisms On the Clearance of Intravenous Busulfan in Adult Patients Undergoing Hematopoietic Cell Transplantation." Blood 114, no. 22 (2009): 1179. http://dx.doi.org/10.1182/blood.v114.22.1179.1179.

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Abstract Abstract 1179 Poster Board I-201 Introduction: Intravenous (iv) busulfan can yield a more consistent dosing and pharmacokinetic profile than oral formulation, but there is still inter-patient variability in systemic exposure with iv busulfan. GST gene polymorphisms may explain the variability because busulfan is metabolized in liver through conjugation with GST family. Thus, we investigated the influence of polymorphisms of 3 GST genes, GSTA1, GSTM1, and GSTT1 on the clearance of iv busulfan in adult patients undergoing hematopoietic cell transplantation (HCT). Patients and Methods: W

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Aguiar, Ernestina Silva de, Juliana Giacomazzi, Aishameriane Venes Schmidt, et al. "GSTM1, GSTT1, and GSTP1 polymorphisms, breast cancer risk factors and mammographic density in women submitted to breast cancer screening." Revista Brasileira de Epidemiologia 15, no. 2 (2012): 246–55. http://dx.doi.org/10.1590/s1415-790x2012000200002.

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Genetic polymorphisms in genes related to the metabolism of xenobiotics, such as genes of the glutathione S-transferases (GSTM1, GSTT1, and GSTP1) superfamily have been associated with an increased risk for breast cancer (BC). Considering the high incidence of BC in the city of Porto Alegre in southern Brazil, the purpose of this study was to characterize genotypic and allelic frequencies of polymorphisms in GSTM1, GSTT1, and GSTP1, and correlate these molecular findings with established risk factors for breast cancer including mammographic density, in a sample of 750 asymptomatic women underg

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Ostapchuk, E. V., and V. V. Godovan. "Influence of GSTM1, GSTT1 and GSTP1 xenobiotic metabolism genes polymorphisms on treatment efficiency in patients with chronic hepatitis C." Kazan medical journal 95, no. 2 (2014): 202–8. http://dx.doi.org/10.17816/kmj2064.

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Aim. To analyze the influence of GSTT1, GSTM1 and GSTP1 genes polymorphism on treatment effectiveness in patients with chronic hepatitis C in Odessa Region using different treatment protocols. Methods. Three groups of patients with chronic hepatitis C were included. Patients of the first group (n=33) were treated with peginterferon alfa-2a and ribavirin, of the second group (n=18) - with tilorone and ribavirin, of the third group (n=26) - with silybi mariani fructuum extract. GSTT1, GSTM1 genes polymorphisms, as well as A313G polymorphism of GSTP1 gene were determined. The treatment effect was

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Chen, Han-chun, Yan-fei Cao, Wei-xin Hu, et al. "Genetic Polymorphisms of Phase II Metabolic Enzymes and Lung Cancer Susceptibility in a Population of Central South China." Disease Markers 22, no. 3 (2006): 141–52. http://dx.doi.org/10.1155/2006/436497.

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A case-control study was conducted for analyzing the genetic polymorphisms of phase II metabolic enzymes in 97 patients with lung cancer and 197 healthy subjects from Han ethnic group of Hunan Province located in Central South China. The results showed that the frequencies of glutathione S-transferase (GST) M1-null (GSTM1-) or GSTT1-null (GSTT1-) genotype alone, or combined form of both in lung cancer patients were significantly higher than those of the controls. Genotypes of combining GSTP1 mutant/GSTM1(-) or GSTP1 mutant/GSTT1(-) led to high risk of lung cancer. Individuals carrying any two

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Camargo Ortega, Victor Raul, Leliette Deyanira Bravo López, Angel Visoso Salgado, Fernando Mejia Sanchez, and Julieta Castillo Cadena. "Polymorphisms in Glutathione S-Transferase M1, T1, and P1 in Patients with Chronic Periodontitis: A Pilot Study." International Scholarly Research Notices 2014 (November 25, 2014): 1–6. http://dx.doi.org/10.1155/2014/135368.

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Background. Although the direct cause of chronic periodontitis is bacterial infection, the progression of this disease depends on genetic and environmental factors, and smoking is a known risk factor in the development and severity of the disease. An individual’s susceptibility may be influenced by polymorphisms in the glutathione S-transferase genes. These genes encode enzymes that metabolize xenobiotic compounds. The aim of this study was to determine the frequency of GSTM1, GSTT1, and GSTP1 polymorphisms in Mexicans with chronic periodontitis. Methods. 60 Mexicans with chronic periodontitis

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Shaikhova, D. R., A. M. Amromina, I. A. Bereza, et al. "Effects of genetic polymorphisms of GSTM1, GSTT1, and GSTP1 genes on blood metal levels in non-ferrous metal alloy smelter operators." Health Risk Analysis, no. 3 (September 2022): 176–81. http://dx.doi.org/10.21668/health.risk/2022.3.17.

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Heavy metal ions are known to induce generation of a large number of reactive oxygen species (ROS). Glutathione S-transferases (GSTs) play an important role in adaptation and response to oxidative stress. GSTM1, GSTT1, and GSTP1 genes have numerous described polymorphisms, the most significant being GSTM1, GSTT1, and GSTP1 Ile105Val deletion ones. Our objective was to study the relationship between the genetic polymorphism of GSTM1, GSTT1, GSTP1 genes and blood levels of metals in smelter operators engaged in crude lead refining. We examined 55 male lead-refining furnace operators working at a

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Franko, Alenka, Katja Goricar, Metoda Dodic Fikfak, Viljem Kovac, and Vita Dolzan. "The role of polymorphisms in glutathione-related genes in asbestos-related diseases." Radiology and Oncology 55, no. 2 (2021): 179–86. http://dx.doi.org/10.2478/raon-2021-0002.

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Abstract Background The study investigated the influence of GCLC, GCLM, GSTM1, GSTT1 and GSTP1 polymorphisms, as well as the influence of interactions between polymorphism and interactions between polymorphisms and asbestos exposure, on the risk of developing pleural plaques, asbestosis and malignant mesothelioma (MM). Subjects and methods The cross sectional study included 940 asbestos-exposed subjects, among them 390 subjects with pleural plaques, 147 subjects with asbestosis, 225 subjects with MM and 178 subjects with no asbestos-related disease. GCLC rs17883901, GCLM rs41303970, GSTM1 null

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Santrić, Veljko, Dejan Dragićević, Marija Matić, et al. "Polymorphisms in Genes Encoding Glutathione Transferase Pi and Glutathione Transferase Omega Influence Prostate Cancer Risk and Prognosis." Front Mol Biosci 8 (April 14, 2021): 620690. https://doi.org/10.3389/fmolb.2021.620690.

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Considering the pleiotropic roles of glutathione transferase (GST) omega class members in redox homeostasis, we hypothesized that polymorphisms in <em>GSTO1</em> and <em>GSTO2</em> might contribute to prostate cancer (PC) development and progression. Therefore, we performed a comprehensive analysis of <em>GSTO1</em> and <em>GSTO2</em> SNPs’ role in susceptibility to PC, as well as whether they might serve as prognostic biomarkers independently or in conjunction with other common GST polymorphisms (<em>GSTM1</em>, <em>GSTT1</em>, and <em>G

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Lakhdar, Ramzi, Sabri Denden, Jalel Knani, et al. "Combined Analysis of EPHX1, GSTP1, GSTM1 and GSTT1 Gene Polymorphisms in Relation to Chronic Obstructive Pulmonary Disease Risk and Lung Function Impairment." Disease Markers 30, no. 5 (2011): 253–63. http://dx.doi.org/10.1155/2011/956250.

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Smoking is considered as the major causal factor of chronic obstructive pulmonary disease (COPD). Nevertheless, a minority of chronic heavy cigarette smokers develops COPD. This suggests important contribution of other factors such as genetic predisposing. Our objective was to investigate combined role of EPHX1, GSTP1, M1 and T1 gene polymorphisms in COPD risk, its phenotypes and lung function impairment. Prevalence of EPHX1, GSTP1, M1 and T1 gene polymorphisms were assessed in 234 COPD patients and 182 healthy controls from Tunisia. Genotypes of EPHX1 (Tyr113His; His139Arg) and GSTP1 (Ile105V

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Economopoulos, Konstantinos P., Theodoros N. Sergentanis, and Nikos F. Vlahos. "Glutathione S-transferase M1, T1, and P1 Polymorphisms and Ovarian Cancer Risk: A Meta-Analysis." International Journal of Gynecologic Cancer 20, no. 5 (2010): 732–37. http://dx.doi.org/10.1111/igc.0b013e3181dedeb5.

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Introduction:Cytosolic glutathione S-transferase (GST) comprises multiple isoenzymes that catalyze reactions between glutathione and lipophilic compounds with electrophilic centers, resulting in the neutralization of toxic compounds, xenobiotics, and products of oxidative stress. Several studies have examined whether GST polymorphisms (GSTM1 null/present genotype, GSTT1 null/present genotype, and GSTP1 Ile105Val) represent risk factors for ovarian cancer, as they all may denote reduced enzyme activity. This meta-analysis aimed to examine the associations between the aforementioned polymorphism

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Settheetham-Ishida, Wannapa, Mayuree Wongpratate, Sophida Phuthong, Sitakan Natphopsuk, and Takafumi Ishida. "Genetic Polymorphism of Glutathione S-transferase and Cervical Cancer Susceptibility in Northeastern Thailand." Asian Pacific Journal of Cancer Biology 5, no. 2 (2020): 35–41. http://dx.doi.org/10.31557/apjcb.2020.5.2.35-41.

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Background: Exposure to certain carcinogens together with host genetic predisposition likely has an influence on cervical carcinogenesis. Objective: Our aim was to evaluate synergistic effects of glutathione S-transferase (GST) polymorphisms and risk behaviors (i.e., smoking and contraceptive use) on squamous cell cervical cancer (SCCA) development in northeastern Thailand. Methods: Subjects were 198 (SCCA) patients and 198 age-matched healthy controls. Multiplex PCR and PCR-RFLP were used to determine GSTT1 and GSTA1 gene polymorphism, respectively. Results: Interaction between the four polym

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Salama, Mona M. S., Mahdi H. A. Abdalla, and Nasr Eldeen Ali Mohammed Gaufri. "Association of Glutathione S Transferase M1, T1, P1 (GSTM1, GSTT1, GSTP1) Gene Polymorphisms with Sickle Cell Anaemia Complications in North Kordofan State, Sudan." Saudi Journal of Medicine 9, no. 04 (2024): 89–99. http://dx.doi.org/10.36348/sjm.2024.v09i04.003.

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Sickle cell anaemia (SCA) is an inherited blood disorder that is characterized by chronic haemolysis and episodes of many clinical complications. The number of people living with sickle cell disease globally increased from 5.46 million in 2000 to 7.74 million in 2021. This study aimed to investigate the association of glutathione S transferase M1, T1, P1 (GSTM1, GSTT1, GSTP1) gene polymorphisms with SCA complications. This was a case-control and hospital-based study, conducted in the SCA center, Alkuaiti Hospital, North Kordofan state, Sudan. Following informed consent, one hundred twenty-six

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Nath, Sayantan, Sambuddha Das, Aditi Bhowmik, Sankar Kumar Ghosh, and Yashmin Choudhury. "The GSTM1 and GSTT1 Null Genotypes Increase the Risk for Type 2 Diabetes Mellitus and the Subsequent Development of Diabetic Complications: A Meta-analysis." Current Diabetes Reviews 15, no. 1 (2018): 31–43. http://dx.doi.org/10.2174/1573399814666171215120228.

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Background:Studies pertaining to association of GSTM1 and GSTT1 null genotypes with risk of T2DM and its complications were often inconclusive, thus spurring the present study.Methods:Meta-analysis of 25 studies for evaluating the role of GSTM1/GSTT1 null polymorphisms in determining the risk for T2DM and 17 studies for evaluating the role of GSTM1/GSTT1 null polymorphisms in development of T2DM related complications were conducted.Results:Our study revealed an association between GSTM1 and GSTT1 null polymorphism with T2DM (GSTM1; OR=1.37;95% CI =1.10-1.70 and GSTT1; OR=1.29;95% CI =1.04-1.61

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Federico, M. H., K. C. Brunialti, G. Castro, et al. "Glutathione-S-transferase genes polymorphisms predict response and progression free survival in head and neck cancer patients treated with cisplatin based chemoradiotherapy." Journal of Clinical Oncology 25, no. 18_suppl (2007): 21127. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.21127.

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21127 Background: Alterations in the function of DNA repair genes and detoxification genes may influence response to cisplatin based chemoradiotherapy in patients (pts) with head and neck cancer. Our purpose was to evaluate the prognostic ability of polymorphisms of three genes glutathione S-transferase (GST), ERCC1 and XPD in patients with head and neck squamous cell carcinoma (HNSCC). Methods: A polymerase chain reaction-restriction fragment length polymorphism (RFLP-PCR) or multiplex PCR approach was used to determine the frequency of the XPD Lys751Gln (n=29), ERCC1 Asn118 (n=50), GSTP1 Ile

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Kassogue, Yaya, Brehima Diakite, Oumar Kassogue, et al. "Genetic polymorphism of drug metabolism enzymes (GSTM1, GSTT1 and GSTP1) in the healthy Malian population." Molecular Biology Reports 47, no. 1 (2019): 393–400. http://dx.doi.org/10.1007/s11033-019-05143-5.

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Abstract Glutathione S-transferase genes, known to be highly polymorphic, are implicated in the process of phase II metabolism of many substrates, including xenobiotics, anticancer and anti-infective drugs. The detoxification activity is linked to individual genetic makeup. Therefore, the identification of alleles and genotypes in these genes within a population may help to better design genetic susceptibility and pharmacogenetic studies. We performed the present study to establish the frequencies of the GSTM1, GSTT1, and GSTP1 c. 313A > G (rs1695) polymorphisms in 206 individuals of the Ma

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Valeeva, Elvira Timeryanovna, Guzel Fanisovna Mukhammadiyeva, and Akhat Barievich Bakirov. "Polymorphism of Glutathione S-transferase Genes and the Risk of Toxic Liver Damage in Petrochemical Workers." International Journal of Occupational and Environmental Medicine 11, no. 1 (2020): 53–58. http://dx.doi.org/10.15171/ijoem.2020.1771.

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Background: Exposure to numerous chemicals, including industrial ones, may result in liver damage. The body susceptibility to the environmental hazards largely depends on the activity of the enzymes in the xenobiotic detoxification system. Function abnormalities of such enzymes due to genetic variations would increase the risk of developing various diseases. Objective: To elucidate the relationship between polymorphism in glutathione S-transferase genes (GSTM1, GSTT1 and GSTP1) and the risk of toxic liver damage in a group of petrochemical workers. Methods: This study was conducted on 72 worke

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Voso, Maria Teresa, Stefan Hohaus, Francesco Guidi, et al. "Prognostic Role of Glutathione S-Transferase (GST) Polymorphisms in Acute Myeloid Leukemia." Blood 110, no. 11 (2007): 1446. http://dx.doi.org/10.1182/blood.v110.11.1446.1446.

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Abstract Glutathione S-transferases (GST) are phase II detoxification enzymes, involved in the metabolism of carcinogens and anti-cancer drugs. Since GSTs have been also shown to interact with kinase complexes during oxidative or chemical stress-induced apoptosis, their polymorphic variants may account for differences in outcome following chemotherapy between individuals. Studying 106 patients (pts) with acute myeloid leukaemia (AML), we have shown that individuals with a GSTM1 and/or GSTT1 deletion were at higher risk of relapse and of shorter overall survival (Voso et al, Blood100:2703, 2002

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Drazdova, E. V., K. V. Kaliasniova, V. E. Syakhovich, and N. А. Dalhina. "Polymorphisms of xenobiotic metabolism enzyme genes cyp2e1, gstm1, gstt1, ephx1 as biomarkers of sensitivity to exposure to water disinfection byproducts (using chloroform as an example)." health risk analysis, no. 1 (March 2023): 157–70. http://dx.doi.org/10.21668/health.risk/2023.1.15.eng.

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Chloroform accumulation in the body and the increase in its steady-state concentrations in blood of exposed people have been established to be associated with polymorphisms of enzyme genes in a genotype involved in metabolism of water disinfection byproducts (A415G of EPHX1 gene, C1091T of CYP2E1 gene, zero mutations of GSTT1 and GSTM1 genes) (р < 0.000001). These polymorphisms in a genotype correlate with higher chloroform levels in blood of people consuming chlorinated drinking water: by 43.8 % and higher for GSTM1 gene polymorphism; by 68.2 % and higher for GSTT1; by 80.4 % and higher fo

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Drazdova, E. V., K. V. Kaliasniova, V. E. Syakhovich, and N. А. Dalhina. "Polymorphisms of xenobiotic metabolism enzyme genes cyp2e1, gstm1, gstt1, ephx1 as biomarkers of sensitivity to exposure to water disinfection byproducts (using chloroform as an example)." Health Risk Analysis, no. 1 (March 2023): 157–70. http://dx.doi.org/10.21668/health.risk/2023.1.15.

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Chloroform accumulation in the body and the increase in its steady-state concentrations in blood of exposed people have been established to be associated with polymorphisms of enzyme genes in a genotype involved in metabolism of water disinfection byproducts (A415G of EPHX1 gene, C1091T of CYP2E1 gene, zero mutations of GSTT1 and GSTM1 genes) (р < 0.000001). These polymorphisms in a genotype correlate with higher chloroform levels in blood of people consuming chlorinated drinking water: by 43.8 % and higher for GSTM1 gene polymorphism; by 68.2 % and higher for GSTT1; by 80.4 % and higher fo

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Negovan, Anca, Mihaela Iancu, Valeriu Moldovan, Simona Mocan, and Claudia Banescu. "The Interaction between GSTT1, GSTM1, and GSTP1 Ile105Val Gene Polymorphisms and Environmental Risk Factors in Premalignant Gastric Lesions Risk." BioMed Research International 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/7365080.

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The study investigated the possible influence of GSTM1, GSTT1, and GSTP1 gene polymorphisms as predisposing factors for premalignant gastric lesions as well as their interaction with H. pylori infection, gastrotoxic drugs, smoking, and alcohol consumption. In this study, 270 patients with a complet set of gastric biopsies and successfully genotyped were finally included. The GSTM1 gene polymorphism had significant contribution in mild/severe endoscopic lesions (p=0.01) as well as in premalignant lesions (p=0.01). The GSTM1 null genotype increased the risk for mucosal defects in H. pylori-negat

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Xiao, Gang. "Association of Genetic Polymorphism of GSTM1 and GSTT1 with the Susceptibility to Antituberculosis Drug-induced Hepatotoxicity in Chinese Population." Journal of Advances in Medicine Science 1, no. 3 (2018): 80. http://dx.doi.org/10.30564/jams.v1i3.56.

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Objective To investigate the relationship between the polymorphism of glutathione S transferase M1, T1(GSTM1, GSTT1) gene and the susceptibility to antituberculosis drug induced hepatotoxicity (ATDH) in patients with tuberculosis. Methods GSTM1 and GSTT1 gene polymorphisms in patients with or without liver toxicity after antituberculous treatment were analyzed using multiple PCR method. Results In ATDH group and control group, the proportion of GSTM1 gene deletion was 58.0% and 50.7%respectively, and the difference was not statistically signifcant (OR=1.322, 95%CI=0.921~1.878), the frequencies

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Kashani, Farah Lotfi, Dor Mohammad Kordi-Tamandani, Roya Sahranavard, Mohammad Hashemi, Farzaneh Kordi-Tamandani, and Adam Torkamanzehi. "Analysis of glutathione S-transferase genes polymorphisms and the risk of schizophrenia in a sample of Iranian population." Neuron Glia Biology 7, no. 2-4 (2011): 199–203. http://dx.doi.org/10.1017/s1740925x12000130.

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Glutathione S-transferases (GSTs) are major intracellular antioxidants, which, impaired in their function, are involved in the progress of schizophrenia (SCZ). The aim of this case-control study was to investigate the association between the polymorphism of glutathione S-transferases M1 (GSTM1), T1 (GSTT1), the glutathione S-transferase P1 gene (GSTP1) and SCZ. We isolated genomic DNA from peripheral blood of 93 individuals with SCZ and 99 healthy control subjects' genotypes analyzing them for GSTM1, GSTT1 and GSTP1 using polymerase chain reaction. The analysis of the gene–gene interaction bet

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Kozlova, Anna Sergeevna, Alexandre Olegovich Pyatibrat, Sergei Borisovich Melnov, Nadezhda Sergeevna Smolnik, and Petr Dmitriyevich Shabanov. "Polymorphisms of xenobiotic biotransformation genes and their role in individualization of pharmacological therapy and support of humans after heavy psychophysical loading." Reviews on Clinical Pharmacology and Drug Therapy 13, no. 2 (2015): 43–48. http://dx.doi.org/10.17816/rcf13243-48.

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We analyzed the frequency distribution of CYP1A1, EPHX1, GSTM1, GSTP1, GSTT1 genes polymorphisms in 111 persons exposed to high physical and mental stress (elite athletes). Qualifications of sportsmen ranged from candidates for master of sports to world-class athlete. Comparative analysis revealed significant differences between the main group and the comparison group in the frequency of GSTM1, GSTT1, CYP1A1 genotypes, and a tendency to a predominance of genotype GSTP1 Val / Val in the main group.

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Stepanova, Ye, I. Kolpakov, V. Vdovenko, V. Zigalo, V. Kondrashova, and O. Leonovich. "MOLECULAR GENETIC ASPECTS OF BRONCHIAL HYPERREACTIVITY IN CHILDREN – RESIDENTS OF RADIOACTIVELY CONTAMINATED AREAS." Проблеми радіаційної медицини та радіобіології = Problems of Radiation Medicine and Radiobiology 25 (2020): 531–42. http://dx.doi.org/10.33145/2304-8336-2020-25-531-542.

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Objective. to determine the relationship between polymorphisms of glutathione S-transferase gene family and bronchial hyperreactivity in children living in radioactively contaminated areas. Materials and methods. School age children-residents of radioactively contaminated areas (RCA), without clinical signs of respiratory pathology were examined. Molecular genetic studies were carried out by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) for further analysis. The GSTT1, GSTM1 gene deletion polymorphism was investigated using multiplex PCR. PCR and PCR-RFLP

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Saad, A. A., P. J. O'Connor, M. H. Mostafa, et al. "Glutathione S-Transferase M1, T1 and P1 Polymorphisms and Bladder Cancer Risk in Egyptians." International Journal of Biological Markers 20, no. 1 (2005): 69–72. http://dx.doi.org/10.1177/172460080502000111.

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Previous studies suggest that bladder cancer risk may vary with GST genotype but these results are inconsistent. The aim of this study was to explore whether GSTM1, GSTT1 and GSTP polymorphisms were associated with increased bladder cancer risk in an Egyptian population. GSTM1, GSTT1 and GSTP1 genotype frequencies were determined in bladder cancer cases (n=72) and healthy controls with no history of malignancies (n=82) using PCR-based techniques. The GSTT1*2 genotype was particularly associated with increased risk (OR 2.71, 95%CI 1.27–5.73) and the GSTM1*2 genotype to a lesser extent (OR 1.63,

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Siraj, Abdul K., Rong Bu, Maha Al-Rasheed, et al. "Association between Drug-Metabolizing Enzymes Polymorphisms and Diffuse Large B-Cell Lymphoma Risk in the Middle Eastern Population." Blood 108, no. 11 (2006): 2043. http://dx.doi.org/10.1182/blood.v108.11.2043.2043.

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Abstract The last four decades have seen significant increase in the incidence of non-Hodgkin’s lymphoma (NHL) as a possible result of increasing environmental carcinogens exposure. Based on the increasing evidence for the association between carcinogens exposure related cancer risk and xenobiotic gene polymorphisms. We have undertaken a case control study on xenobiotic gene polymorphisms in Saudi individuals with a diagnosis of diffuse large B-cell lymphoma (DLBCL). Polymorphisms in five genes (CYP1A1, GSTT1, GSTP1, GSTM1 and NQO1) were characterized in 187 individuals with DLBCL and 513 norm

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Đorđević, Katarina, Milena Peličić, Uroš Bumbaširević, and Vesna Ćorić. "The association of SOD2 and GST gene polymorphisms with the risk of development and prognosis of papillary renal cell carcinoma." Medicinski podmladak 73, no. 2 (2022): 20–27. http://dx.doi.org/10.5937/mp73-35160.

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Introduction: Redox imbalance is an important factor in both carcinogenesis and progression of renal cell carcinoma. Numerous studies are focused on finding potential biomarkers that can aid in early detection, as well as in monitoring disease progression. Among the candidates there are genes coding for antioxidant enzymes - superoxide dismutase 2 (SOD2) and glutathione S -transferase (GST). Aim: This study aims to assess the role of SOD2 and GST genes polymorphisms as risk biomarkers for papillary renal cell carcinoma (pRCC), along with their impact on the survival of these patients. Material

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Klusek, Justyna, Ewelina Błońska-Sikora, Bartosz Witczak, et al. "Glutathione S-transferases gene polymorphism influence on the age of diabetes type 2 onset." BMJ Open Diabetes Research & Care 8, no. 2 (2020): e001773. http://dx.doi.org/10.1136/bmjdrc-2020-001773.

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IntroductionType 2 diabetes (T2D) is a multifactorial disease affecting mostly adults older than 40 years. The aim of the study was to examine GST gene polymorphism influence on the risk of T2D, especially in young adults.Research design and methods200 diabetic patients and 221 healthy controls participated in this study. Three GST gene polymorphism have been analyzed: GSTP1 (single-nucleotide polymorphism Ile105Val), homozygous deletion of GSTT1 (null/null) and GSTM1 (null/null), using TaqMan real-time quantitative PCR.ResultsThe distribution of examined polymorphisms was similar in patient g

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Menha, Swellam, Sayed Mahmoud Magda, E. Mosa Tamer, and K. Mohamed Aly. "Influences of Glutathione S-Transferase Gene (GSTT1, GSTM1) Polymorphisms in Acute Lymphoblastic Leukemia." International Journal of Current Pharmaceutical Review and Research 7, no. 4 (2016): 229–32. https://doi.org/10.5281/zenodo.12680995.

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Background: Genetic variations in glutathione -S- transferase (GST), a gene that encodes carcinogenic metabolizingenzymes, could account for a proportion in leukemia. Authors investigated the genotyping polymorphism in glutathione –S-transferase mu1 (GSTM1) and theta 1 (GSTT1) in acute lymphoblastic leukemia (ALL). By using multiplex PCR, GSTM1and GSTT1 polymorphisms were genotyped in 153 ALL adult patients and 90 healthy individuals served as control.Results: Of the 153 ALL patients, 78.4% and 33.3% showed homozygous deletions in GSTT1 and GSTM1, respectively.Significant association (P

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Ribrag, Vincent, Serge Koscielny, Olivier Casasnovas, et al. "Pharmacogenetic study in Hodgkin lymphomas reveals the impact of UGT1A1 polymorphisms on patient prognosis." Blood 113, no. 14 (2009): 3307–13. http://dx.doi.org/10.1182/blood-2008-03-148874.

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AbstractHodgkin lymphoma is a highly curable malignancy, but treatment outcome might be influenced by inherited gene polymorphisms determining anticancer agent metabolism. We prospectively collected peripheral blood lymphocytes from 313 patients with Hodgkin lymphomas to analyze GSTP1, GSTM1, GSTT1, UGT1A1, and CYP3A4 enzyme gene polymorphisms. All patients were treated with chemotherapy, associated with radiotherapy when they had localized disease. There was no difference for GSTP1, GSTM1, and GSTT1 as well as for UGT1A1 and CYP3A4 polymorphism distributions between Hodgkin lymphoma patients

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Žuntar, Irena, Roberta Petlevski, Slavica Dodig, and Sanja Popović-Grle. "GSTP1, GSTM1 and GSTT1 genetic polymorphisms and total serum GST concentration in stable male COPD." Acta Pharmaceutica 64, no. 1 (2014): 117–29. http://dx.doi.org/10.2478/acph-2014-0003.

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Abstract The aim of this study was to test the hypothesis that glutathione- S-transferase (GST) genotypes were associated with COPD. GSTP1, GSTM1 and GSTT1 genotypes were determined by DNA methods and GST activity spectrophotometrically in older male Caucasian Croats (non- -smokers, ex-smokers, and smokers) with stable COPD (n = 30) and sex/age matched controls (n = 60). The distribution of GSTP1 genotypes and alleles in controls vs. COPD showed a statistical difference (p < 0.05). The odds ratio of CC/CT+TT (wild type GSTP1 exon 6 vs. joint heterozygous and mutant homozygous GSTP1 exon 6)

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Беляева, Е. В., Т. А. Баирова, О. А. Ершова, et al. "Genetic polymorphisms of xenobiotic detoxification system in the populations of Russians and Buryats." Nauchno-prakticheskii zhurnal «Medicinskaia genetika 22, no. 4 (2023): 17–31. http://dx.doi.org/10.25557/2073-7998.2023.04.17-31.

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Полиморфизм генов системы детоксикации ксенобиотиков ассоциирован с лекарственной устойчивостью и такими заболеваниями человека как рак, болезнь Паркинсона, болезнь Альцгеймера, атеросклероз, цирроз печени, старение, образование катаракты, бесплодие, инсомния. Частота полиморфных вариантов генов GSTs варьирует в различных мировых популяциях. Цель данного исследования − охарактеризовать частотное распределение генотипов генов GSTM1, GSTT1, а также генотипов и аллелей полиморфных вариантов Ile105Val, Ala114Val гена GSTP1 в популяциях русских и бурят, проживающих в Восточной Сибири и установить м

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Pašalić, Daria, and Natalija Marinković. "Genetic polymorphisms of the CYP1A1, GSTM1, and GSTT1 enzymes and their influence on cardiovascular risk and lipid profile in people who live near a natural gas plant." Archives of Industrial Hygiene and Toxicology 68, no. 1 (2017): 46–52. http://dx.doi.org/10.1515/aiht-2017-68-2772.

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Abstract The aim of this cross-sectional study was to see whether genetic polymorphisms of the enzymes CYP1A1, GSTM1, and GSTT1 are associated with higher risk of coronary artery disease (CAD) and whether they affect lipid profile in 252 subjects living near a natural gas plant, who are likely to be exposed to polycyclic aromatic hydrocarbons (PAHs). Fasting serum concentrations of biochemical parameters were determined with standard methods. Genetic polymorphisms of CYP 1A1 rs4646903, rs1048943, rs4986883, and rs1799814 were genotyped with polymerase chain reaction-restriction fragment length

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Ji, Fang, Jian Zhang, Xiaowen Ding, et al. "Associations of GST Gene Polymorphisms and GST Enzyme Activity with the Development of Noise-Induced Hearing Loss in Chinese Han Males." Public Health Genomics 27, no. 1 (2024): 168–76. http://dx.doi.org/10.1159/000541618.

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Introduction: In noise-induced hearing loss (NIHL), glutathione S-transferases (GSTs) play a pivotal role as antioxidants in cochlear protection. Nevertheless, the variability in population and environmental factors complicates the interpretation of research findings on the association among GST gene polymorphism, GST enzyme activity, and NIHL, leading to inconsistent results. To explore the potential correlation between them, we took a cross-sectional survey. Methods: For workers with NIHL, standard 1:1 propensity score matching was applied to create a highly comparable control group. Multipl

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Vogl, Florian D., Emanuela Taioli, Christine Maugard, et al. "Glutathione S-transferases M1, T1, and P1 and Breast Cancer: A Pooled Analysis." Cancer Epidemiology, Biomarkers & Prevention 13, no. 9 (2004): 1473–79. http://dx.doi.org/10.1158/1055-9965.1473.13.9.

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Abstract The glutathione S-transferase (GST) genes are involved in the metabolism of various carcinogens. Deletion polymorphisms in the genes GSTM1 and GSTT1 and a base transition polymorphism at codon 105 (Ile→Val) in GSTP1 were investigated in relation to breast cancer risk. Tobacco smoking and reproductive factors were examined as potential effect modifiers. Individual data from seven case-control studies were pooled within the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens. To measure the effect of GSTs on breast cancer risk, odds ratios and 95% co

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Şekerci, Abdüsselam, Gokhan Bagci, Hande Küçük Kurtulgan, and Ferhan Candan. "Glutathione S-transferase gene polymorphism, total antioxidant status, and blood pressure changes in androgenic alopecia." Anadolu Kliniği Tıp Bilimleri Dergisi 30, no. 2 (2025): 295–301. https://doi.org/10.21673/anadoluklin.1673127.

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Aim: To investigate the relationship of glutathione S-transferase gene polymorphism with total antioxidant capacity and blood pressure changes in patients with androgenic alopecia. Methods: Hamilton-Norwood classification was used for the diagnosis and staging of androgenic alopecia (AGA), and all individuals were evaluated by the same physician. Family history of AGA was questioned; body mass index (BMI), lipid profile, blood pressure (BP) levels, total oxidative stress (TOS), total antioxidant status (TAS), and glutathione S-transferase (GST) gene polymorphisms were evaluated. Polymerase cha

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Ntais, Christos, Anastasia Polycarpou, and John P. A. Ioannidis. "Association of GSTM1, GSTT1, and GSTP1 Gene Polymorphisms with the Risk of Prostate Cancer: A Meta-analysis." Cancer Epidemiology, Biomarkers & Prevention 14, no. 1 (2005): 176–81. http://dx.doi.org/10.1158/1055-9965.176.14.1.

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Abstract The glutathione S-transferase (GST) gene superfamily encodes for enzymes involved in conjugation of electrophilic compounds to glutathione. Several polymorphisms in the GST genes have been implicated as risk factors for prostate cancer. We did a meta-analysis of 11 studies with GSTM1 genotyping (2,063 prostate cancer cases and 2,625 controls), 10 studies with GSTT1 genotyping (1,965 cases and 2,554 controls), and 12 studies with GSTP1 genotyping (2,528 cases and 3,076 controls). The random effects odds ratio was 1.08 [95% confidence interval (95% CI), 0.93-1.25, no significant between

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Almeida, Micaela, Mafalda Soares, José Fonseca-Moutinho, Ana Cristina Ramalhinho, and Luiza Breitenfeld. "Influence of Estrogenic Metabolic Pathway Genes Polymorphisms on Postmenopausal Breast Cancer Risk." Pharmaceuticals 14, no. 2 (2021): 94. http://dx.doi.org/10.3390/ph14020094.

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Estrogen metabolism plays an important role in tumor initiation and development. Lifetime exposure to high estrogens levels and deregulation of enzymes involved in estrogen biosynthetic and metabolic pathway are considered risk factors for breast cancer. The present study aimed to evaluate the impact of mutations acquisition during the lifetime in low penetrance genes that codify enzymes responsible for estrogen detoxification. Genotype analysis of GSTM1 and GSTT1 null polymorphisms, CYP1B1 Val432Leu and MTHFR C677T polymorphisms was performed in 157 samples of women with hormone-dependent bre

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Ada, Ahmet Oguz, Serdar Bilgen, Volkan Karacaoglan, et al. "Association between the TP53 and CYP2E1*5B gene polymorphisms and non-small cell lung cancer." Archives of Industrial Hygiene and Toxicology 67, no. 4 (2016): 311–16. http://dx.doi.org/10.1515/aiht-2016-67-2812.

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Abstract Non-small cell lung cancer (NSCLC) is the most common form of lung cancer. Genetic polymorphisms in tumour suppressor genes and genes encoding xenobiotic metabolising enzymes alter the activity of their corresponding enzymes and are important individual susceptibility factors for NSCLC. Because of the lack of information in literature, the aim of our study was to investigate the role of the tumour suppressor gene TP53 (Arg72Pro) and the xenobiotic metabolising CYP2E1*5B gene polymorphisms on the risk of NSCLC development. The study population consisted of 172 patients and 172 controls

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Cilenšek, Ines, Sara Mankoč, Mojca Globočnik Petrovič, and Daniel Petrovič. "GSTT1 Null Genotype Is a Risk Factor for Diabetic Retinopathy in Caucasians with Type 2 Diabetes, whereas GSTM1 Null Genotype Might Confer Protection against Retinopathy." Disease Markers 32, no. 2 (2012): 93–99. http://dx.doi.org/10.1155/2012/675628.

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Aim: Substantial data indicate that oxidative stress is involved in the development of diabetic retinopathy (DR). The aim of the present study was to investigate whether the genetic polymorphisms: polymorphic deletions of glutathione S-transferases M1 (GSTM1) and T1 (GSTT1) and Ile105Val of the GSTP1 are associated with DR in Slovenian patients with type 2 diabetes.Methods: In this cross sectional case-control study 604 unrelated Slovene subjects (Caucasians) with type 2 diabetes mellitus were enrolled: 284 patients with DR (cases) and the control group of 320 subjects with type 2 diabetes of

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Juras, Ana, Kristina Crkvenac Gornik, Martina Held, et al. "Association of Glutathione Transferase M1, T1, P1 and A1 Gene Polymorphism and Susceptibility to IgA Vasculitis." International Journal of Molecular Sciences 25, no. 14 (2024): 7777. http://dx.doi.org/10.3390/ijms25147777.

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Endothelial cell injury is a hallmark of IgA vasculitis (IgAV), possibly associated with various factors, including oxidative stress. Certain single nucleotide polymorphisms (SNPs) of glutathione S-transferases (GST) genes have been shown to increase susceptibility to oxidative stress. The objective of our study was to evaluate the gene polymorphisms of GSTM1, GSTT1, GSTP1, and GSTA1 in patients with IgAV. DNA was extracted from the blood of 124 children with IgAV and 168 age-matched healthy controls. A higher frequency of the GSTM1 null genotype was observed in patients with gastrointestinal

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Goekkurt, Eray, Salah-Eddin Al-Batran, Jörg T. Hartmann, et al. "Pharmacogenetic Analyses of a Phase III Trial in Metastatic Gastroesophageal Adenocarcinoma With Fluorouracil and Leucovorin Plus Either Oxaliplatin or Cisplatin: A Study of the Arbeitsgemeinschaft Internistische Onkologie." Journal of Clinical Oncology 27, no. 17 (2009): 2863–73. http://dx.doi.org/10.1200/jco.2008.19.1718.

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PurposeTo evaluate the association of germ-line polymorphisms of genes that may impact treatment outcome of platinum and fluorouracil combination chemotherapy in advanced gastric cancer (AGC).Patients and MethodsBlood samples of 156 patients enrolled onto a phase III study comparing fluorouracil, leucovorin, and oxaliplatin with fluorouracil, leucovorin, and cisplatin were collected. Polymorphisms within genes of TS, MTHFR, MTR, OPRT, XPD, ERCC1, XRCC1, XPA, GSTP1, GSTT1, and GSTM1 were genotyped using polymerase chain reaction–based techniques.ResultsMedian overall survival (OS) was 11.8 mont

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Tawfik, Noha Z., Hoda Y. Abdallah, Mona E. Abdullah, Hagar F. Alshaarawy, and Mona A. Atwa. "Glutathione S-transferase M1 and T1 gene polymorphisms in psoriasis patients: a pilot case-control study." Egyptian Journal of Dermatology and Venereology 43, no. 3 (2023): 200–207. http://dx.doi.org/10.4103/ejdv.ejdv_5_23.

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Background The exact etiology of psoriasis remains unknown; nevertheless, it has been found that oxidative stress plays a vital role. Among the multiple antioxidant enzymes, genetic polymorphisms in the Glutathione S-Transferases (GSTs) led to an imbalance in the antioxidant system, resulting in increased levels of reactive oxygen species. Accordingly, the polymorphism in these genes could increase the susceptibility to psoriasis. Objectives To assess the association between Glutathione S-Transferase M1 (GSTM1) and Glutathione S Transferase Theta-1 (GSTT1) gene polymorphisms in psoriasis patie

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S.T., Raza, Abbas S., Ahmad A., Ahmed F., Zaidi Z.H., and Mahdi F. "Association of Glutathione-S-Transferase (GSTM1 and GSTT1) and FTO Gene Polymorphisms with Type 2 Diabetes Mellitus Cases in Northern India." Balkan Journal of Medical Genetics 17, no. 1 (2014): 47–54. http://dx.doi.org/10.2478/bjmg-2014-0027.

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Abstract Type 2 diabetes mellitus (T2DM) is growing in an epidemic manner across the world and India has the world’s largest number of diabetic subjects. The present study was carried out to investigate the association of glutathione-S-transferase (GSTM1, GSTT1) and fat mass and obesity associated (FTO) gene polymorphisms with T2DM patients and controls, and its role in increasing the susceptibility to T2DM. A total of 198 subjects (101 T2DM patients and 97 controls) participated in this study. GSTM1, GSTT1 and FTO gene polymorphisms in the patients and controls were evaluated by polymerase ch

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Oldenburg, Jan, Sigrid M. Kraggerud, Milada Cvancarova, Ragnhild A. Lothe, and Sophie D. Fossa. "Cisplatin-Induced Long-Term Hearing Impairment Is Associated With Specific Glutathione S-Transferase Genotypes in Testicular Cancer Survivors." Journal of Clinical Oncology 25, no. 6 (2007): 708–14. http://dx.doi.org/10.1200/jco.2006.08.9599.

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Purpose Cisplatin, a cornerstone of combination chemotherapy in the treatment of testicular cancer, induces hearing impairment with considerable interindividual variations. These differences might be a result of functional polymorphisms in cisplatin-detoxifying enzymes like glutathione S-transferases (GSTs). Patients and Methods We identified 173 cisplatin-treated testicular cancer survivors (TCSs) who had participated in a long-term survey that included audiometric testing and lymphocyte sampling. The hearing decibel thresholds at 4,000 Hz were categorized into leveled scales by normative dec

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Isakova, Zh, Vyacheslav Kipen, K. Aytbaev, et al. "POLYMORPHISMS IN GSTM1, GSTP1 AND GSTT1 GENES AND BREAST CANCER RISK IN WOMEN FROM KYRGYZSTAN." Problems in oncology 66, no. 5 (2020): 514–23. http://dx.doi.org/10.37469/0507-3758-2020-66-5-514-523.

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Aim: We studied the intergenic interactions and the contribution of polymorphic loci for GSTT1, GSTM1, GSTP1 genes in the formation of predisposition to breast cancer (ВС) in women of Kyrgyz nationality. Material and method: The study included 87 women of the Kyrgyz ethnic group with the morphologically verified diagnosis of BC and 96 women without cancer and chronic diseases. Genotyping of single-nucleotide polymorphisms (SNPs) was performed using PCR-RFLP for rs1695 GSTP1 gene. Deletion polymophisms in GSTT1 and GSTM1 genes were determined using allele-specific real-time PCR. Analysis of the

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Santric, Veljko, Milica Djokic, Sonja Suvakov, et al. "GSTP1 rs1138272 Polymorphism Affects Prostate Cancer Risk." Medicina 56, no. 3 (2020): 128. http://dx.doi.org/10.3390/medicina56030128.

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Background and Objectives: One of the most frequent genetic alterations reported to date in prostate cancer (PC) is aberrant methylation of glutathione transferase P1 (GSTP1). Taking into consideration the involvement of oxidative stress in PC pathogenesis and recent advances in scientific understanding of the role of GSTP1*Ala114Val rs1138272 polymorphism in carcinogenesis, we hypothesized that this single-nucleotide polymorphism (SNP) influences the risk of PC independently of, or in combination with, other GST polymorphisms, including GSTP1*IIe105Val rs1695 or GSTM1 and GSTT1 deletion polym

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Santrić, Veljkoo, Milica Đokić, Sonja Suvakov, et al. "GSTP1 rs1138272 Polymorphism Affects Prostate Cancer Risk." Medicina 56, no. 3 (2020): 128. https://doi.org/10.3390/medicina56030128.

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Background and Objectives: One of the most frequent genetic alterations reported to date in prostate cancer (PC) is aberrant methylation of glutathione transferase P1 (GSTP1). Taking into consideration the involvement of oxidative stress in PC pathogenesis and recent advances in scientific understanding of the role of GSTP1*Ala114Val rs1138272 polymorphism in carcinogenesis, we hypothesized that this single-nucleotide polymorphism (SNP) influences the risk of PC independently of, or in combination with, other GST polymorphisms, including GSTP1*IIe105Val rs1695 or GSTM1 and GSTT1 deletion polym

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Aguiar, E., J. Giacomazzi, E. I. Palmero, et al. "Null allele polymorphisms in the GSTT1 and GSTM1 genes in 705 women from a mammographic breast cancer screening program (NMPOA) in southern Brazil." Journal of Clinical Oncology 25, no. 18_suppl (2007): 21091. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.21091.

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21091 Background: Several genetic polymorphisms in genes related with metabolism have been associated with breast cancer (BC) risk. Among these, the gluthatione-S-transferase M1 and T1 null genotypes have been associated with slightly increased BC risk in some populations. In Brazil, BC is a significant public health problem, due to its high incidence and mortality rates. In Porto Alegre, Brazil`s southernmost capital, a multidisciplinary BC Prevention Project - the Nucleo Mama Porto Alegre Cohort (NMPOA)- was started in 2004 and includes a mammographic screening program for women ages 40–69 y

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