To see the other types of publications on this topic, follow the link: GSVD.
Dissertations / Theses on the topic 'GSVD'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 37 dissertations / theses for your research on the topic 'GSVD.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.
1
Wo, Siew Mun. "Analysis of a GSVD Approach to Full-State Feedback Control Design Using Singular Value Localization of Eigenvalues." Ohio University / OhioLINK, 1989. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1239731736.
Full text
2
Pereira, Ivanildo Freire. "Par?metro de regulariza??o em problemas inversos: estudo num?rico com a transformada de Radon." Universidade Federal do Rio Grande do Norte, 2013. http://repositorio.ufrn.br:8080/jspui/handle/123456789/18649.
Full textAbstract:
Made available in DSpace on 2015-03-03T15:32:43Z (GMT). No. of bitstreams: 1
IvanildoFP_DISSERT.pdf: 6193808 bytes, checksum: 2b4b204c68da306ef20f2a99dc91d9c9 (MD5)
Previous issue date: 2013-09-20Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior
In general, an inverse problem corresponds to find a value of an element x in a suitable vector space, given a vector y measuring it, in some sense. When we discretize the problem, it usually boils down to solve an equation system f(x) = y, where f : U Rm ! Rn represents the step function in any domain U of the appropriate Rm. As a general rule, we arrive to an ill-posed problem. The resolution of inverse problems has been widely researched along the last decades, because many problems in science and industry consist in determining unknowns that we try to know, by observing its effects under certain indirect measures. Our general subject of this dissertation is the choice of Tykhonov?s regulaziration parameter of a poorly conditioned linear problem, as we are going to discuss on chapter 1 of this dissertation, focusing on the three most popular methods in nowadays literature of the area. Our more specific focus in this dissertation consists in the simulations reported on chapter 2, aiming to compare the performance of the three methods in the recuperation of images measured with the Radon transform, perturbed by the addition of gaussian i.i.d. noise. We choosed a difference operator as regularizer of the problem. The contribution we try to make, in this dissertation, mainly consists on the discussion of numerical simulations we execute, as is exposed in Chapter 2. We understand that the meaning of this dissertation lays much more on the questions which it raises than on saying something definitive about the subject. Partly, for beeing based on numerical experiments with no new mathematical results associated to it, partly for being about numerical experiments made with a single operator. On the other hand, we got some observations which seemed to us interesting on the simulations performed, considered the literature of the area. In special, we highlight observations we resume, at the conclusion of this work, about the different vocations of methods like GCV and L-curve and, also, about the optimal parameters tendency observed in the L-curve method of grouping themselves in a small gap, strongly correlated with the behavior of the generalized singular value decomposition curve of the involved operators, under reasonably broad regularity conditions in the images to be recovered
Problemas inversos, usualmente recaem em resolver alguma equa??o do tipo f(x) = b, onde cada equa??o fi(x) = bi pode ser pensada como uma medida de um dado x a ser recuperado. Usualmente s?o mal postos, no sentido de corresponderem a equa??es que podem n?o ter solu??o exata, podem ainda ter muitas solu??es, ou ainda, o que ? o mais comum, ter solu??es muito inst?veis a ru?dos na obten??o de b. H? v?rias formas de regularizar a obten??o de solu??es de tais problemas e a mais popular seria a de Tykhonov, que corresponde a: Minimizar ||f(x) b||2 + l ||L(x x0) ||2 (I) A regulariza??o pretendida corresponde a se escolher o operador l, de tal forma que o problema I tenha solu??es est?veis com perturba??es em b e que aproximem solu??es do problema de m?nimos quadrados usual, no caso de se fazer l 0. O primeiro termo de (I) representa o ajuste aos dados e o segundo termo penaliza a solu??o de forma a regularizar o problema e produzir uma solu??o est?vel a ru?dos. Se l = 0, isto significa que estamos procurando uma solu??o de quadrados m?nimos para o problema, o que usualmente ? insuficiente para problemas mal postos. O termo de regulariza??o adicionado introduz um vi?s na solu??o ao penalizar o ajuste com um termo adicional. Se L for a identidade, por exemplo, isto significa que estamos apostando que a solu??o estaria relativamente pr?xima de x0. Se L for o operador gradiente, estamos apostando que a solu??o x ? razoavelmente suave. Nas aplica??es, L usualmente ? escolhido como um operador adaptado ao problema estudado e de forma se valer de informa??es a priori dispon?veis sobre as solu??es procuradas. A escolha do par?metro l > 0 ? crucial neste m?todos, pelo fato que se l ? excessivo, isto tende a enfraquecer excessivamente o ajuste aos dados, induzindo um ajuste da solu??o ? x0. Se l for pequeno demais a regulariza??o pretendida acaba n?o acontecendo e a solu??o do problema (I) usualmente acaba ficando muito inst?vel e contaminada por ru?dos. H? v?rias t?cnicas dispon?veis na literatura para tal escolha, sobretudo se f ? uma fun??o linear f(x) = Ax. O objetivo da disserta??o ? o de estudar algumas destas t?cnicas de ajuste do par?metro l no caso de operadores discretizados, vale dizer, x no Rn. Em especial, destacamos os m?todos de ajuste do par?metro l reconhecidos na literatura como L-curve, GCV e m?todo da discrep?ncia, e objetiva-se comparar estes m?todos em testes feitos com a transformada de Radon e tendo como regularizador um operador de derivada de primeira ordem. Os resultados dos testes realizados revelam pontos interessantes na rela??o entre os diferentes estimadores para o par?metro de regulariza??o e que sugerem um aprofundamento te?rico al?m do escopo desta disserta??o
3
Bricault, Gary S. "GSD : an interactive window-oriented debugger for the AT & T UNIX-PC /." Online version of thesis, 1989. http://hdl.handle.net/1850/10549.
Full text
4
Kappler, Andreas. "Zivilmacht oder Militärmacht? die Bedeutung des Vertrages von Lissabon für das Leitbild der Europäischen Union am Beispiel der neuen GSVP." Saarbrücken VDM Verlag Dr. Müller, 2008. http://d-nb.info/995753601/04.
Full text
5
Fährmann, Ingo. "Die Bundeswehr im Einsatz für Europa die Beteiligung Deutschlands an der gemeinsamen Sicherheits- und Verteidigungspolitik (GSVP) - Zulässigkeit nach dem Vertrag von Lissabon." Baden-Baden Nomos, 2009. http://d-nb.info/999101919/04.
Full text
6
Fährmann, Ingo [Verfasser]. "Die Bundeswehr im Einsatz für Europa : Die Beteiligung Deutschlands an der Gemeinsamen Sicherheits- und Verteidigungspolitik (GSVP) - Zulässigkeit nach dem Vertrag von Lissabon / Ingo Fährmann." Baden-Baden : Nomos Verlagsgesellschaft mbH & Co. KG, 2010. http://d-nb.info/1110057709/34.
Full text
7
Lee, Hyun Kyung. "GSD Typ II und Typ IV: Biochemische und molekulargenetische Analyse bei Patienten mit Mangel an saurer α-Glukosidase bzw. mit Branchingenzymmangel." Diss., lmu, 2005. http://nbn-resolving.de/urn:nbn:de:bvb:19-39303.
Full text
8
Stensson, Lily. "Spatial Accuracy in Orthophoto produced using UAV Photographic Images." Thesis, Karlstads universitet, Fakulteten för samhälls- och livsvetenskaper, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-46245.
Full textAbstract:
The popularity of using UAV in image-taking for the production of 3D models and orthophotos has increased over time. Karlskoga Municipality has recently acquired an UAV to produce their own 3D models and orthophotos. This project paper aims to study the geospatial accuracy of the orthophotos and DEM files produced using the images taken with their UAV. The flight takes only a few minutes but a considerable time is spent in the production processes. Difficulty is experienced in determining the right center point for most GCPs. Produced orthophotos in the software Photoscan have a resolution from 1.7 to 2.4 centimeters while DEM files have a resolution from 3.4 to 4.8 centimeters. Four orthophotos and four DEM files are produced where GCPs are used and not used and at two different flight heights, 76 and 105 meters. The spatial data of the ten GCPs are identified on the orthophotos and DEM files in ArcMap and compared with GNSS NRTK measurements and Lantmäteriet's data. A visual control in terms of completeness of data, alignment, residual tilt and scale is also done. Standard deviations in plane for orthophotos there GCPs are not used are greater than 2 meters, while there GCPs are used are around 0.7 meters. Standard deviations for DEM files are observed at 0.8 meters.
9
Rakocevic, Andrej, and Pourja Autieri. "Individrelaterade utmaningar i globala systemutvecklingsprojekt." Thesis, Linnéuniversitetet, Institutionen för informatik (IK), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-45877.
Full textAbstract:
Global systemutveckling (GSD) är en ökande trend inom systemutvecklingsbranschenoch möjliggör för verksamheter att reducera utvecklingskostnaderna, få tillgång tillexpertis till lägre kostnader samt öka flexibilitet och effektivitet genom att konstantbedriva systemutveckling över olika tidszoner. Global mjukvaruutveckling ikombination med agila metodologier visar sig bli allt vanligare då framgångsrika agilaprojekt kan producera programvara av högre kvalitet som bättre uppfylleranvändarnas behov. Tidigare forskning konstaterar dock att utmaningar ochkomplikationer kan uppstå i globala mjukvaruutvecklingsmiljöer ur perspektivet avindivider som arbetar i geografiskt separerade projektgrupper. Syftet med dennastudie har varit att undersöka vilka problem och utmaningar som individer upplever iglobala mjukvaruutvecklingsmiljöer där den agila metodologin Scrum tillämpas.Problemen och utmaningarna som i denna studie undersökts relaterar till följandehuvudområden: kommunikation, språkliga och kulturella skillnader,gruppsammanhållning och laganda samt kunskapshantering. Studien syftar även tillatt redogöra för hur de uppkomna utmaningarna förslagsvis kan hanteras. Enundersökning har genomförts på ett mjukvaruutvecklingsföretag i Växjö som verkarinom ekonomitjänstebranschen. En kvalitativ undersökningsmetodik i form avsemistrukturerade intervjuer har genomförts med arbetstagare som arbetar i ettmjukvaruutvecklingsprojekt som bedrivs globalt.Slutsatserna som dras av studien är att individer som arbetar inom globalamjukvaruutvecklingsprojekt ställs inför flera utmaningar. Kommunikationsrelateradesvårigheter upplevs bl.a. på grund av bristen på informell kommunikation vilketresulterar i misskommunikation, missförstånd och långa svarstider. För en förbättradkommunikation kan kombinationen av synkrona och asynkrona verktyg användassamt skärmdelning och videosamtal. Scrum aktiviteter som daily scrums ochretrospectives kan även förbättra kommunikationen inom projektgruppen. Avseendekulturella skillnader visar studien att det upplevs svårt att definiera om utmaningarkan relateras till kulturella skillnader mellan olika länder eller om det avser skillnaderi organisationskulturer. Språkrelaterade skillnader visar sig upplevas som en barriäroch leder bl.a. till svårigheter att uttrycka sina idéer och tankar och att arbetetförsvåras eftersom att översättning krävs. Beträffande gruppsammanhållning upplevsdet råda en bristande gruppsammanhållning när projektmedlemmarna är fysisktseparerade och att gruppsammanhållningen tenderar att öka inom respektive separeradgrupp snarare än projektgruppen som helhet. Den geografiska spridningen påverkaräven tilliten inom projektgruppen. För ökad gruppsammanhållning och tillit ärinformella sammanträffar en nyckelfaktor. Medlare ses även som en nyckelfigur föratt länka samman teammedlemmarna i de fysiskt separerade grupperna. Avseendekunskapshantering upplevs den geografiska spridningen inom projektgruppen som enmöjlighet att dra nytta av varandras olika bakgrunder och erfarenheter för att på så sättöka kunskapen inom hela projektgruppen. Utmaningar som relaterar tillkunskapshantering är att samma misstag kan begås flera gånger inom projektet p.g.a.en avsaknad av informellt kunskapsutbyte. För förbättrad kunskapshantering inomprojektgruppen ges förslag på användning av t.ex. code reviews, checklistor ochkunskapstävlingar för främjandet av kunskapshantering inom projektgruppenGlobal software development (GSD) is a growing trend within the software industryand enables companies to reduce development costs, get access to expertise to lowercosts and increase flexibility and efficiency by constantly conducting softwaredevelopment across different time zones. Global software development combinedwith agile methodologies proves to be more common as successful agile projects canproduce software of higher quality that better meet user needs. Previous researchconcludes however that challenges and complications can arise in GSD environmentsfrom the perspective of the individuals working in geographically separated projectteams. The purpose of this study was to examine the problems and challenges thatindividuals experience in GSD environments where the agile Scrum methodology isapplied. The problems and challenges that have been examined relate to the followingareas: communication, language and cultural differences, group cohesion and teamspirit and knowledge management. The study also aims to explain and exemplify howthe challenges can be mitigated. A study has been conducted at a softwaredevelopment company in Växjö operating in the finance service industry. Aqualitative research method in the form of semi-structured interviews was conductedwith employees working in a global software development project.The conclusions drawn from the study are that individuals working within GSDprojects face several challenges. Communication related difficulties are experiencedpartly due to of the lack of informal communication, which results in failedcommunication, misunderstandings and long response times. In order to improve thecommunication, a combination of synchronous and asynchronous tools can be used aswell as screen sharing and video calls. Scrum activities such as daily scrums andretrospectives can also improve the communication within the project team.Regarding cultural differences, the study shows that it’s difficult to distinguishwhether challenges are related to cultural differences between the countries, orwhether it relates to differences in organizational cultures. The language-relateddifferences prove to be perceived as a barrier and lead to difficulties for individuals toexpress their ideas and thoughts, as well as understanding other individuals. Thelanguage differences also hamper the work because translation is required. Challengesrelated to group cohesion include that individual’s experience a lack of groupcohesion when project members are physically separated and that the group cohesiontends to increase in each separated group instead of the project team as a whole. Thegeographic dispersion also affects the trust within the project team. In order improvegroup cohesion and trust within the team informal gatherings are a key factor.Mediators are also seen as a key figure for linking the team members in physicallyseparated groups. Knowledge management is seen as an opportunity to benefit fromeach other's different backgrounds and experiences to increase the knowledge withinthe entire team. Challenges related to knowledge management are that the samemistakes can be committed several times in the project due to a lack of informalknowledge exchange. In order to improve knowledge management within the project,suggestions are given such as the use of code reviews, checklists and to organizeknowledge competitions to promote knowledge sharing within the project team.
10
Embretsen, Daniel, and Labib Hyder. "Scrum in Global Software Development : An Ethnographic Case Study of Scrum's Mitigation Effects on Global Software Development Challenges." Thesis, Uppsala universitet, Företagsekonomiska institutionen, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-325779.
Full textAbstract:
The increasing technological advancement and globalization has seen a rise in offshoring of IT-development, also known as Global Software Development (GSD). One of the most common countries for offshoring has been India with its increasingly competent population.The use of GSD to leverage highly skilled and low-cost labor also creates challenges in three main categories; Coordination, Control and Communication. These challenges arise due to socio-cul-tural, geographical and temporal distances.The use of the Scrum development framework is claimed by scholars to mitigate these issues. This study is grounded on Hossain, Bannerman & Jeffery’s (2011) research framework, which summa-rizes the current body of literature on Scrum’s mitigating effect on commonly occurring challenges in a GSD environment. Due to the scarcity of empirical data on the research framework, the authors of this thesis conducted an ethnographical study on location in India at Indpro, a company founded in Sweden and studied two projects. The purpose of this study is to both evaluate and provide suggestions for expansion of the Hossain et al. (2011) framework with ethnographically collected empirical support, which prior to this was primarily based on experience reports. This study also aims to identify GSD challenges and mitigation strategies that occur in the setting of an experi-enced organization conversant with Scrum methodology in a GSD context.The purpose of this study is to contribute to an increased empirical understanding of how Scrum is being used in a GSD environment, what challenges are prevalent in a distributed GSD environ-ment and how those challenges might be addressed or mitigated. In this study, parts of Hossain et al. (2011) framework are evaluated and suggestions for expanding it through mitigation strategies such as Planning, high quality ICT-Mediate Synchronous and asynchronous communication are specified. Implications for practitioners include the proposal to follow Scrum Practices more me-ticulously to receive all of Scrums inherent mitigating effects.
11
Bergqvist, Groth Anton, and Johan Vesslén. "Off-Shore Blackboxing & Global Software Development : En studie av utmaningar och möjligheter med distribuerad systemförvaltning." Thesis, Umeå universitet, Institutionen för informatik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-91176.
Full textAbstract:
Global Software Development (GSD) is based on a geographical distance where teams are spread throughout the world. The related research have for a long time addressed the challenges presented by geographical distances. GSD is basically a necessity for many businesses to use in order to reduce development costs, reduce production time and to maintain high quality. The study aims to investigate the relationship between the reality of a specific maintenance project. Thus, our research question: How do distributed maintenance teams experience temporal, geographical and socio-cultural distances? To achieve the purpose of the study, we chose to perform a case study of a global consulting company which recently started a new system maintenance project. The data collection was done through interviews and observations at the premises of the consulting company. We have confirmed the previous research and come up with our own contributions to the field. The findings of our thesis provides aspects of communication, coordination and control related to the three distances stated in our research question. A new collective term has also emerged, off-shore blackboxing.
12
Dalbelo, Thaís Maria. "O índice de Poincaré-Hopf e generalizações no caso singular." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/55/55135/tde-15032011-163543/.
Full textAbstract:
Neste trabalho,estudamos o índice de Poincaré-Hopf, definido para singularidades isoladas de campos de vetores sobre variedades diferenciáveis. Além disso, investigamos algumas definições de índices de campos de vetores definido sem variedades singulares, como o índice de Schwartz e o índice GSV. Estudaremos estes invariantes no caso específico em que (V; 0) é um germe de uma interseção completa com singularidade isolada na origemIn this work, we study thePoincaré-Hopf index, defined for isolated singularities of vector fields on manifolds. Moreover, we investigate some definitions of indices of vector fields defined on singular varieties, as the Schwartz index and the GSV index. We study these invariants in the case where (V; 0) is a germ of a complete intersection with an isolated singularity at the origin
13
Le, Guilcher Arnaud. "Méthodes de propagation d'interfaces." Thesis, Paris Est, 2014. http://www.theses.fr/2014PEST1030/document.
Full textAbstract:
Ce travail porte sur la résolution de problèmes faisant intervenir des mouvements d'interfaces. Dans les différentes parties de cette thèse, on cherche à déterminer ces mouvements d'interfaces en résolvant des modèles approchés consistant en des équations ou des systèmes d'équations sur des champs. Les problèmes obtenus sont des équations paraboliques et des systèmes hyperboliques. Dans la première partie (chapitre 2), on étudie un modèle simplifié pour la propagation d'une onde de souffle en dynamique des fluides compressibles. Ce modèle peut s'écrire sous la forme d'un système hyperbolique, et on construit un algorithme résolvant numériquement ce système par une méthode de type Fast-Marching. On mène également une étude théorique de ce système pour déterminer des solutions de référence et tester la validité de l'algorithme. Dans la deuxième partie (chapitres 3 à 5), les équations approchées sont de type parabolique, et on cherche à montrer l'existence de solutions de type régime permanent à ces équations. Dans les chapitres 3 et 4, on étudie une équation générique en une dimension associée à des phénomènes de réaction-diffusion. Dans le chapitre 3, on montre l'existence de solutions quasi-planes pour un terme de réaction (terme non-linéaire) assez général, et dans le chapitre 4 on utilise ces résultats pour montrer l'existence d'ondes pulsatoires progressives dans le cas spécifique d'une non-linéarité bistable. Le modèle étudié dans le chapitre 5 est un modèle de champ de phase approchant un modèle de dynamique des dislocations dans un cristal, dans un domaine correspondant physiquement à une source de Frank-ReadThis work is about the resolution of problems associated with the motion of interfaces. In each part of this thesis, the goal is to determine the motion of interfaces by the use of approached models consisting of equations or systems of equation on fields. The problems we get are parabolic equations and hyperbolic systems. In the first part (Chapter 2), we study a simplified model for the propagation of a shock wave in compressible fluid dynamics. This model can be written as a hyperbolic system, and we construct an algorithm to solve it numerically by a Fast-Marching like method. We also conduct a theoretical study of this system to determine reference solutions and test the algorithm. In the second part (Chapters 3 to 5), the approached models yield parabolic equations, and our goal is to show the existence of permanent regime solutions for these equations. Chapter 3 and 4 are dedicated to the study of a generic one-dimensional equation modelling reaction-diffusion phenomena. In Chapter 3, we show the existence of plane-like solutions for a general reaction term, and in Chapter 4 we use this result to show the existence of pulsating travelling waves in the specific case of a bistable nonlinearity. In Chapter 5, we study a phase-field model approaching a model for the dynamics of dislocations in a crystal, in a domain corresponding to a Frank-Read source
14
Khan, Abid Ali, and Zaka Ullah Muhammad. "Exploring the Accuracy of Existing Effort Estimation Methods for Distributed Software Projects-Two Case Studies." Thesis, Blekinge Tekniska Högskola, Sektionen för datavetenskap och kommunikation, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-4126.
Full textAbstract:
The term “Globalization” brought many challenges with itself in the field of software development. The challenge of accurate effort estimation in GSD is one among them. When talking about effort estimation, the discussion starts for effort estimation methods. There are a number of effort estimation methods available. Existing effort estimation methods used for co-located projects are might not enough capable to estimate effort for distributed projects. This is why; ratio of failure of GSD projects is high. It is important to calibrate existing methods or invent new with respect to GSD environment. This thesis is an attempt to explore the accuracy of effort estimation methods for distributed projects. For this purpose, the authors selected three estimation approaches: COCOMO II, SLIM and ISBSG. COCOMO II and SLIM are two well known effort estimation methods, whereas, ISBSG is used to check the trend of a project depending upon its (ISBSG’s) repository. The selection of the methods and approaches was based on their popularity and advantages over other methods/approaches. Two finished projects from two different organizations were selected and analyzed as case studies. The results indicated that effort estimation with COCOMO II deviated 15.97 % for project A and 9.71% for project B. Whereas, SLIM showed the deviation of 4.17% for project A and 10.86 % for project B. Thus, the authors concluded that both methods underestimated the effort in the studied cases. Furthermore, factors that might cause deviation are discussed and several solutions are recommended. Particularly, the authors state that existing effort estimation methods can be used for GSD projects but they need calibration by considering GSD factors to achieve accurate results. This calibration will help in process improvement of effort estimation.
15
Hussain, Waqar. "Requirements Change Management in GlobalSoftware Development: A Case Study inPakistan." Thesis, Linnaeus University, School of Computer Science, Physics and Mathematics, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-6079.
Full textAbstract:
Global software development has been a phenomenon of growing interest for almost past decade or so; and its adoption trend continues to gain momentum. Globally distributed work istaken up as an alternative to single-site mainly because of the economic and strategic benefits itoffers. Software development at geographically distributed environment is not a straightforwardtask and entails numerous challenges which are unique to this form of development.
Requirements change management is considered challenging even in the best of conditions andit becomes even harder when performed at geographically distributed development locations.There is no existing model for managing requirements change in globally distributed softwaredevelopment context.
This study uses qualitative research method to explore requirements change managementprocess and investigates the underlying causes of requirements change in geographicallydistributed software development. The research work proposes a model for requirementschange management for global software development. This model tries to incorporate the roles,activities and artifacts identified in the change management models.
16
Chen, Bernard. "Discovery and Extraction of Protein Sequence Motif Information that Transcends Protein Family Boundaries." Digital Archive @ GSU, 2009. http://digitalarchive.gsu.edu/cs_diss/42.
Full textAbstract:
Protein sequence motifs are gathering more and more attention in the field of sequence analysis. The recurring patterns have the potential to determine the conformation, function and activities of the proteins. In our work, we obtained protein sequence motifs which are universally conserved across protein family boundaries. Therefore, unlike most popular motif discovering algorithms, our input dataset is extremely large. As a result, an efficient technique is essential. We use two granular computing models, Fuzzy Improved K-means (FIK) and Fuzzy Greedy K-means (FGK), in order to efficiently generate protein motif information. After that, we develop an efficient Super Granular SVM Feature Elimination model to further extract the motif information. During the motifs searching process, setting up a fixed window size in advance may simplify the computational complexity and increase the efficiency. However, due to the fixed size, our model may deliver a number of similar motifs simply shifted by some bases or including mismatches. We develop a new strategy named Positional Association Super-Rule to confront the problem of motifs generated from a fixed window size. It is a combination approach of the super-rule analysis and a novel Positional Association Rule algorithm. We use the super-rule concept to construct a Super-Rule-Tree (SRT) by a modified HHK clustering, which requires no parameter setup to identify the similarities and dissimilarities between the motifs. The positional association rule is created and applied to search similar motifs that are shifted some residues. By analyzing the motifs results generated by our approaches, we realize that these motifs are not only significant in sequence area, but also in secondary structure similarity and biochemical properties.
17
Nekkanti, Lakshmi Sowjanya. "Impact of coordination challenges on quality of global software development projects." Thesis, Blekinge Tekniska Högskola, Institutionen för programvaruteknik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-13323.
Full textAbstract:
Context. Global software development (GSD) gained huge recognition in today’s business world. Most of the software companies day by day are striving hard to evolve globally where software is developed in the context of different environmental settings that are distanced on various factors like geography, timezone, culture and language. Coordination is the factor that plays one of the prominent roles in such a setting for effective teamwork and project success. Although numerous efforts has been done in this research area, there has been no proper evidence from industry about the impact of these coordination challenges on the overall quality of the software when being developed in a distributed setting. Objectives. The purpose of this study is to examine and identify the coordination challenges and risks faced in global software development projects that has a negative impact on the quality of software from practitioner’s perspective. It also identify the tools, methods, and techniques that are used in industry to overcome these challenges and maintain quality standards. Methods. The aims and objectives of our study are fulfilled by conducting survey among practitioners working in GSD projects all around the globe. Further, 10 interviews are conducted with practitioners working in different companies and geographical locations in order to gain a detailed understanding of the impact of identified coordination challenges on the quality of software in GSD projects. Results. A total of 50 survey responses are recorded, out of which 48 respondents specify that coordination challenges has a negative impact on software quality in GSD context. By the ratings given by the participants, we identified the challenges and risks that had a major impact. Mixed results are obtained during interviews where most of them prioritized coordination as a major problem in GSD projects. It also included that use of some tools, methods and processes help them in overcoming this issue. The quality attributes that are mostly affected due to the challenges in GSD projects are also identified. Conclusions. After the analysis of survey results, the coordination challenges and associated risks in GSD projects are identified. They were found to havemostly negative impact on software quality. After thematic analysis of interview results, we observed that though the impact of coordination challenges is negative, its extent of implication is moderate in most cases.
18
Shahriyari, Salman. "Distributed Agile Development; Suitability, Challenges and Practices." Thesis, Högskolan i Borås, Institutionen Handels- och IT-högskolan, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-17340.
Full textAbstract:
Uncertainty in software development and business environment and the need to increase thespeed of development have driven organizations to search for methods that are responsive toboth change and speed. Providing iterative development, agile development involvescustomers and users through different phases of development, and delivers frequent releasesof software to customer while receives the corresponding feedback. Using this approach, agiledevelopment thus aims at addressing mentioned issues of speed and uncertainty whiledeveloping only what customer needs from the beginning of the project. On the other hand,distributed software development is used in many organizations to reach global talent andglobal market. The problems associated with distributed software development such as lack ofenough communication and team coherency, have forced project managers to combine it withagile to mitigate these social problems. This study focuses on distributed agile development,its suitability for a typical project and its challenges and deficiencies. Text analysis andinterviews using qualitative methods are used in this scientific research work. From thetheoretical view point, different text covering agile methodology, distributed development andcombination of them were considered. This study covered two parts: first, an evaluation ofagile and distributed development opportunities and problems to help determine whether ornot distributed development is suitable for a project and second, considering the challengesonce starting to use this method and practices required to regard them. For the empirical part,the focus was put on Volvo IT employees by having seven interviews with members who arecurrently active in distributed agile development. These interviews were used to compare andverify the finding of the theoretical part. The results of the study were categorized into twosections. In the first part, important elements required to verify the suitability of using thismethod are provided. The recommended factors for this evaluation are cost, productivity,customer, team structure, etc. In the second part, the challenges of using distributed agiledevelopment were categorized into four parts: (a) challenges of selected agile method, whichthe focus in this study is Scrum, (b) challenges with time-zone differences, (c) communicationchallenges and (d) finally team building challenges. The required practices to address thesechallenges were also provided.Program: Masterutbildning i Informatik
19
Gerych, Petr. "Analýza globálních meteorologických dat." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2012. http://www.nusl.cz/ntk/nusl-236608.
Full textAbstract:
The thesis generally describes matters of data warehouses and knowledge discovery in databases. Then it focuses on the meteorological databases and their problems. The practical part of thesis describes design methods for data mining project, NOAA Global Surface Summary of the Day (GSOD), which is then implemented in two different ways using the Pentaho tools. Finally, an evaluation and comparison of these two approaches.
20
Hunnicutt, Robert Lane. "The Relationship of the Learning Styles of High School Teachers and Computer Use in the Classroom." Thesis, University of North Texas, 2005. https://digital.library.unt.edu/ark:/67531/metadc5580/.
Full textAbstract:
This study sought to determine if the dominant learning styles of high school teachers is related to the amount of time computers are used in the classroom by students. It also examined the types of software used by those teachers, and their levels of technology adoption. Subjects (N=177) were from high schools in a large urban school district. Instrumentation included the Gregorc Style Delineator, a modified version of the Snapshot Survey and the Stages of Adoption of Technology. An ANOVA showed no statistical significance between teachers with different dominant learning styles in the numbers of minutes per week that computers were utilized in their classrooms with students. A chi square test showed no statistical significance in the types of software used in the classrooms of teachers with different dominant learning styles. A chi square test showed no statistical significance in the Stages of Technology Adoption of teachers with different dominant learning styles.
21
Ochei, Laud Charles. "Architecting the deployment of cloud-hosted services for guaranteeing multitenancy isolation." Thesis, Robert Gordon University, 2017. http://hdl.handle.net/10059/2448.
Full textAbstract:
In recent years, software tools used for Global Software Development (GSD) processes (e.g., continuous integration, version control and bug tracking) are increasingly being deployed in the cloud to serve multiple users. Multitenancy is an important architectural property in cloud computing in which a single instance of an application is used to serve multiple users. There are two key challenges of implementing multitenancy: (i) ensuring isolation either between multiple tenants accessing the service or components designed (or integrated) with the service; and (ii) resolving trade-offs between varying degrees of isolation between tenants or components. The aim of this thesis is to investigate how to architect the deployment of cloud-hosted service while guaranteeing the required degree of multitenancy isolation. Existing approaches for architecting the deployment of cloud-hosted services to serve multiple users have paid little attention to evaluating the effect of the varying degrees of multitenancy isolation on the required performance, resource consumption and access privilege of tenants (or components). Approaches for isolating tenants (or components) are usually implemented at lower layers of the cloud stack and often apply to the entire system and not to individual tenants (or components). This thesis adopts a multimethod research strategy to providing a set of novel approaches for addressing these problems. Firstly, a taxonomy of deployment patterns and a general process, CLIP (CLoud-based Identification process for deployment Patterns) was developed for guiding architects in selecting applicable cloud deployment patterns (together with the supporting technologies) using the taxonomy for deploying services to the cloud. Secondly, an approach named COMITRE (COmponent-based approach to Multitenancy Isolation Through request RE-routing) was developed together with supporting algorithms and then applied to three case studies to empirically evaluate the varying degrees of isolation between tenants enabled by multitenancy patterns for three different cloud-hosted GSD processes, namely-continuous integration, version control, and bug tracking. After that, a synthesis of findings from the three case studies was carried out to provide an explanatory framework and new insights about varying degrees of multitenancy isolation. Thirdly, a model-based decision support system together with four variants of a metaheuristic solution was developed for solving the model to provide an optimal solution for deploying components of a cloud-hosted application with guarantees for multitenancy isolation. By creating and applying the taxonomy, it was learnt that most deployment patterns are related and can be implemented by combining with others, for example, in hybrid deployment scenarios to integrate data residing in multiple clouds. It has been argued that the shared component is better for reducing resource consumption while the dedicated component is better in avoiding performance interference. However, as the experimental results show, there are certain GSD processes where that might not necessarily be so, for example, in version control, where additional copies of the files are created in the repository, thus consuming more disk space. Over time, performance begins to degrade as more time is spent searching across many files on the disk. Extensive performance evaluation of the model-based decision support system showed that the optimal solutions obtained had low variability and percent deviation, and were produced with low computational effort when compared to a given target solution.
22
Thompson, Kenneth Parker. "A Political History of U.S. Commercial Remote Sensing, 1984-2007: Conflict, Collaboration, and the Role of Knowledge in the High-Tech World of Earth Observation Satellites." Diss., Virginia Tech, 2007. http://hdl.handle.net/10919/30235.
Full textAbstract:
The political history of U.S. commercial remote sensing began in 1984 when the U.S. government first attempted to commercialize its civil earth observation satellite system " Landsat. Since then, the high technology of earth imaging satellite systems has generated intense debates and policy conflicts, primarily centered on U.S. government concerns over the national security and foreign policy implications of high-resolution commercial satellite systems. Conversely, proponents of commercial observation satellites have urged U.S. policymakers to recognize the scientific and socio-economic utility of commercial remote sensing and thus craft and implement regulatory regimes that allow for a greater degree of information openness and transparency in using earth observation satellite imagery. This dissertation traces and analyzes that tumultuous political history and examines the policy issues and social construction of commercial remote sensing to determine the role of knowledge in the effective crafting and execution of commercial remote sensing laws and policies.
Although individual and organizational perspectives, interests, missions, and cultures play a significant role in the social construction of commercial observation satellite systems and programs, the problem of insufficient knowledge of the myriad dimensions and complex nature of commercial remote sensing is a little studied but important component of this social construction process. Knowledge gaps concerning commercial remote sensing extend to various dimensions of the subject matter, such as the global, economic, technical, and legal/policy aspects.
Numerous examples of knowledge voids are examined to suggest a connection between deficient knowledge and divergent policy perceptions as they relate to commercial remote sensing. Relevant knowledge voids are then structurally categorized to demonstrate the vastness and complexity of commercial remote sensing policy issues and to offer recommendations on how to fill such knowledge gaps to effect increased collaboration between the US government and the U.S. commercial remote sensing industry. Finally, the dissertation offers suggestions for future STS studies on policy issues, particularly those that focus on the global dimensions of commercial remote sensing or on applying the knowledge gap concept advanced by this dissertation to other areas of science and technology policymaking.Ph. D.
23
Ridoux, Julien. "Contribution au développement d'une méthode de calcul rapide de propagation des ondes de souffle en présence d'obstacles." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066193/document.
Full textAbstract:
La simulation directe des ondes de souffle générées par une explosion maîtrisée, ou accidentelle, est un problème délicat du fait des différentes échelles spatiales en jeu. De plus, en environnement réel (topographie, zone urbaine, …), l’onde de souffle interagit avec les obstacles géométriques en se réfléchissant, se diffractant et se recombinant. La forme du front devient complexe, rendant difficile voire impossible une estimation a priori des effets des explosions.Ce travail de thèse contribue à la mise au point d’une méthode de calcul rapide des ondes de souffle en présence d’obstacles. Il repose sur des modèles hyperboliques simplifiés de propagation d'ondes de choc extraits de la littérature, où seul le front incident est modélisé. Ceci permet une réduction significative du coût des simulations : les 5 équations d'Euler 3D sont réduites à un problème 2D à 2 équations. L’analyse du problème de Riemann met en évidence l’absence de solution de ces modèles lors de la diffraction sur un coin convexe dans certaines configurations fréquemment rencontrées en pratique. L’extension des modèles aux ordres supérieurs ne permet pas de corriger ce défaut. Nous levons cette limitation au travers d'une modification ad hoc. L’effet de souffle consécutif à une explosion est ensuite introduit à partir d’une loi expérimentale pression/distance. Du point de vue numérique, un algorithme Lagrangien conservatif de suivi de front est développé en 2D. Les tests montrent que ce nouveau modèle se compare favorablement à l’expérience, avec une réduction de plusieurs ordres de grandeur du temps de calcul en comparaison des méthodes de résolution directe des équations d’EulerThe direct numerical simulation of blast waves (accidental or industrial explosions) is a challenging task due to the wide range of spatial and temporal scales involved. Moreover, in a real environment (topography, urban area …), the blast wave interacts with the geometrical obstacles resulting in reflection, diffraction and waves recombination phenomena. The shape of the front becomes complex, which limits the efficiency of simple empirical methods.This thesis aims at contributing to the development of a fast running method for blast waves propagation in presence of obstacles. This is achieved through the use of simplified hyperbolic models for shock waves propagation such as Geometrical Shock Dynamics (GSD) or Kinematic models. These models describe only the leading shock front. This leads to a drastic reduction of the computational cost, from 5 Euler equations at 3D to a 2D problem with 2 equations. However, the study of the Riemann problem shows that the solution of these models does not always exist in the case of the diffraction over a convex corner. We propose an ad-hoc extension of GSD in order to remove this limitation. The blast effects are also recovered through an empirical law available in free field. From a numerical point of view, a 2D conservative Lagrangian algorithm has been implemented and validated. First comparisons with experimental data show the good behaviour of this new model at nearly free computational cost compared to direct Euler methods
24
Darnell, Christian, and Christian Wilczoch. "Real Time Positioning; Construction and implementation of a GPS-Communicator." Thesis, Linköping University, Department of Electrical Engineering, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1481.
Full textAbstract:
The first half of the Masters thesis is the result of a survey made on the behalf of the Swedish company KORDAB International AB. The survey includes an overview of different positioning systems and some wireless communication techniques available on the market today. Positioning systems discussed are GPS, DGPS, AGPS and GSM positioning. Mobile Internet connections through mobile phones and communication through radio modems are mentioned and described as examples of wireless communication techniques. Examples of techniques described are HSCSD, GPRS, UMTS and MOBITEX. KORDAB is in the starting blocks to implement a real time positioning feature into their own technical information system GEOSECMA. This survey will give them a base which will help them to decide on which system to use for this feature.
The second half of the thesis includes parts concerning a prototype made to exemplify how KORDAB could implement the real time positioning feature into GEOSECMA. The NMEA 0183 protocol, reference systems and transformation are described to give the necessary background knowledge for the construction and functionality of the prototype. The prototype is a GPS-communicator made as an interface between a GPS-receiver and GEOSECMA and its functionality is also described in this second half of the thesis. Feasible applications are also discussed to show the possibilities real time positioning gives. One application discussed is “Zoom and Auto highlighting”. This application is designed to help user of GEOSECMA to zoom in the map and highlighting the nearest object at current location.
25
Gärtner, Vilson Cristiano. "Um ambiente integrado para apoio ao desenvolvimento distribuído de software." Universidade do Vale do Rio dos Sinos, 2011. http://www.repositorio.jesuita.org.br/handle/UNISINOS/3248.
Full textAbstract:
Submitted by CARLA MARIA GOULART DE MORAES (carlagm) on 2015-04-06T17:18:33Z
No. of bitstreams: 1
VilsonGartnerComputacao.pdf: 9068377 bytes, checksum: 6ace07d8901f11d83ef8a8c13f4f62c7 (MD5)Made available in DSpace on 2015-04-06T17:18:33Z (GMT). No. of bitstreams: 1 VilsonGartnerComputacao.pdf: 9068377 bytes, checksum: 6ace07d8901f11d83ef8a8c13f4f62c7 (MD5) Previous issue date: 2011
CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
O Desenvolvimento Distribuído de Software (DDS) é um modelo de desenvolvimento que vem se intensificando nos últimos anos. Também conhecido como Desenvolvimento Global de Software (DGS), esse modelo de desenvolvimento é realizado por equipes em diferentes localizações geográficas. Entre os fatores que contribuem para esse aumento, está a necessidade de negócio das corporações, que buscam redução de custos, recursos qualificados e necessidade de uma presença global. Em outros casos, se deve ao surgimento de novos movimentos de desenvolvimento de software, como a comunidade de software livre, um exemplo bem sucedido de DDS. Apesar da necessidade ou mesmo da conveniência de desenvolver o software de forma distribuída, é extremamente difícil fazê-lo com sucesso. A separação física traz uma série de problemas e desafios interessantes que recém estão começando a ser compreendidas: questões estratégicas, questões culturais, comunicação inadequada, gestão do conhecimento, alocação de tarefas, confiança, questões técnicas, entre outros. Desde que surgiu, o DDS mudou grande parte da tradição do desenvolvimento de software e, para manter o seu mercado, as organizações não podem depender das mesmas competências e tecnologias de engenharia de software utilizadas no desenvolvimento interno. Nesse sentido, o presente trabalho tem por objetivo auxiliar na redução dos problemas e dificuldades trazidos por esse modelo de desenvolvimento, através da implementação de um ambiente de desenvolvimento cujas ferramentas foram definidas com base em estudos e trabalhos relacionados ao tema.
The Distributed Software Development (DSD) is a development model that has been intensified in recent years. Also known as Global Software Development (GSD), this development model is done by teams in different geographical locations. Among the factors that have contributed to this increase, there is the corporations business need of seeking ways to reduce costs, seeking skilled resources and having a global presence. In other cases, it is due to the emergence of new movements in software development, such as the free software community, a successful example of DSD. Despite the need or even desirability of developing software in a distributed way, it is extremely difficult to do this successfully. Physical separation has a number of interesting problems and challenges that are just beginning to be understood: strategic issues, cultural issues, inadequate communication, knowledge management, task allocation, trust, technical issues, among others. DSD has changed much of the tradition of software development since it appeared. Organizations cannot rely on the same skills and software engineering technologies used internally to maintain this new market. In this way, this work aims to help to reduce the problems and difficulties brought by this type of development, through the implementation of a software development environment whose tools were defined based on studies related to the topic.
26
Liu, Tianxao. "Proposition d'un cadre générique d'optimisation de requêtes dans les environnements hétérogènes et répartis." Thesis, Cergy-Pontoise, 2011. http://www.theses.fr/2011CERG0513.
Full textAbstract:
Dans cette thèse, nous proposons un cadre générique d'optimisation de requêtes dans les environnements hétérogènes répartis. Nous proposons un modèle générique de description de sources (GSD), qui permet de décrire tous les types d'informations liées au traitement et à l'optimisation de requêtes. Avec ce modèle, nous pouvons en particulier obtenir les informations de coût afin de calculer le coût des différents plans d'exécution. Notre cadre générique d'optimisation fournit les fonctions unitaires permettant de mettre en œuvre les procédures d'optimisation en appliquant différentes stratégies de recherche. Nos résultats expérimentaux mettent en évidence la précision du calcul de coût avec le modèle GSD et la flexibilité de notre cadre générique d'optimisation lors du changement de stratégie de recherche. Notre cadre générique d'optimisation a été mis en œuvre et intégré dans un produit d'intégration de données (DVS) commercialisé par l'entreprise Xcalia - Progress Software Corporation. Pour des requêtes contenant beaucoup de jointures inter-site et interrogeant des sources de grand volume, le temps de calcul du plan optimal est de l'ordre de 2 secondes et le temps d'exécution du plan optimal est réduit de 28 fois par rapport au plan initial non optimiséThis thesis proposes a generic framework for query optimization in heterogeneous and distributed environments. We propose a generic source description model (GSD), which allows describing any type of information related to query processing and optimization. With GSD, we can use cost information to calculate the costs of execution plans. Our generic framework for query optimization provides a set of unitary functions used to perform optimization by applying different search strategies. Our experimental results show the accuracy of cost calculus when using GSD, and the flexibility of our generic framework when changing search strategies. Our proposed approach has been implemented and integrated in a data integration product (DVS) licensed by Xcalia – Progress Software Corporation. For queries with many inter-site joins accessing large size data sources, the time used for finding the optimal plan is in the order of 2 seconds, and the execution time of the optimized plan is reduced by 28 times, as compared with the execution time of the non optimized original plan
27
CHEN, YU-HSIN, and 陳育欣. "Applying the GSVD for Solving Generalized Eigenvalue Problems." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/25251126317360419595.
Full textAbstract:
碩士輔仁大學
數學系研究所
94
In this thesis, we consider solving the generalized eigenvalue problem ${A^TAx=lambda B^TBx}$, where $Ainmathbb{R}^{m imes n},~Binmathbb{R}^{p imes n}$ and usually $mgeq n,~pgeq n$, and ${Ax=lambda Bx}$, where {A} and {B} are symmetric positive definite matrices. We study the effect of using generalized singular value decomposition method (GSVD) to deal with the problem. The GSVD method is reducing {A} and {B} to diagonal forms by singular value decomposition. The GSVD is stable and faster than the M-W method and the QZ method. Numerical experiments are presented to compare the results.
28
Ponnapalli, Sri Priya. "Higher-order generalized singular value decomposition : comparative mathematical framework with applications to genomic signal processing." Thesis, 2010. http://hdl.handle.net/2152/ETD-UT-2010-08-1635.
Full textAbstract:
The number of high-dimensional datasets recording multiple aspects of a single phenomenon is ever increasing in many areas of science. This is accompanied by a fundamental need for mathematical frameworks that can compare data tabulated as multiple large-scale matrices of di erent numbers of rows. The only such framework to date, the generalized singular value
decomposition (GSVD), is limited to two matrices. This thesis addresses this limitation and de fines a higher-order GSVD
(HO GSVD) of N > 2 datasets, that provides a mathematical framework that can compare multiple high-dimensional datasets tabulated as large-scale matrices of different numbers of rows.text
29
Landau, Dustin James. "Multiple Approaches to Novel GSD Ia Therapies." Diss., 2016. http://hdl.handle.net/10161/13358.
Full textAbstract:
Glycogen storage disease type Ia is an autosomal recessive disorder caused by a mutation in the glucose-6-phosphatase (G6Pase) catalytic subunit, encoded in humans by G6PC. G6Pase dephosphorylates glucose-6-phosphate (G6P) in the liver to generate glucose that can be shuttled to the bloodstream to maintain normoglycemia. Patients with GSD Ia typically present at 6 months of age with sever hypoglycemia, which is lethal if untreated. The current treatment is a strict dietary regimen in which children must be fed every 2 hours overnight or given nasogastric tube feeding, and adults must consume uncooked cornstarch around the clock to maintain normal blood sugar levels. This treatment maintains survival but fails to prevent other symptoms related to metabolism of the excess G6P, and patients develop hepatic adenomas that may become hepatocellular carcinoma later in life, in addition to progressive renal complications.
To overcome the problems persisting during dietary therapy, the Koeberl lab has sought to develop gene therapy approaches that use adeno-associated virus (AAV) vectors to replace the G6pase activity, restoring normoglycemia and normal metabolic processes. However, the vast majority of AAV-delivered genetic material exists as episomes that do not replicate as cells divide, so the effects of AAV gene therapy on GSD Ia mouse and dog models have proven temporary. We hypothesized that driving integration of therapeutic vector genomes into an affected individual's genome would improve beneficial effects' longevity.
We tested several approaches to accomplish this, and have found positive effects using a zinc finger nuclease (ZFN) that targets the mouse safe harbor ROSA26 locus to induce homologous recombination of the G6PC donor vector into the mouse genome. We were able to see an improvement in mouse survival to 8 months of age, an increase in G6Pase activity at 3 months of age, and a decrease in glycogen accumulation at 3 months of age, when the ZFN vector is administered alongside the G6PC vector, compared with mice that received the G6PC vector alone.
We have also taken an alternative approach to overcoming the long-term complications of the current dietary treatment, which would augment rather than replace the current treatment. We have examined several drugs known to induce autophagy in other disease models or cell culture systems, to determine if we could manipulate autophagic activity in G6PC knockdown hepatocytes or GSD Ia mice. We have found positive results using rapamycin, a well-studied MTOR inhibitor, in mice and cells, and have screened several other drugs as well, finding positive effects for bezafibrate, mifepristone, carbamazepin, and lithium chloride, in terms of lipid reduction (which accumulates as a symptom of GSD Ia) and/or LC3-II enhancement, which is reduced in GSD Ia due to downregulation of autophagy during G6P accumulation.
Dissertation
30
Lu, Hua. "Characterization of a novel baculovirus, gonad-specific virus, GSV." 1997. https://scholarworks.umass.edu/dissertations/AAI9809360.
Full textAbstract:
A newly discovered, nonoccluded baculovirus GSV has been reported to be a causative agent of sterility in adult corn ear-worms, Helicoverpa zea. Previous studies conducted by Hamm et al. (1996) and our laboratory indicated that it is an unusual insect virus with strict tissue tropism and the ability to establish persistent infections in vivo. After acquiring purified virus from infected adult insects, two permissive cell culture systems, TN-368 and Ld652Y were established for GSV replication in vitro. The cell culture-derived virus was confirmed to have the same morphology, biological activity and genetic identity as that of GSV recovered from insects. Using a cell culture system, several genetically pure GSV cloned isolates were acquired by plaque purification. The replication cycle of the virus including ultrastructural studies, viral DNA replication and virus specific protein synthesis were investigated in these two cell lines and interestingly, it was found that the exact same virus isolate had a different biology in the different permissive cell lines. Difference in the molecular biology of virus replication in these two cell lines was also observed. This suggests that host factors play an important role in determining the different host-viral interaction of the virus. In addition, biochemical properties of the GSV genome were investigated. The genome size was estimated using pulse-field gel electrophoresis to be 215-235 kb. CsCl-EtBr density gradient centrifugation indicated that GSV has a supercoiled, circular genome. Purified viral structural proteins, envelope proteins and glycoproteins were analyzed by SDS-PAGE and a total 16 of viral structural proteins were identified, three of them are glycosylated and five of these proteins are likely to be virus envelope or matrix components. Studies of GSV specific protein synthesis, DNA replication and transcription in the presence of specific inhibitors suggests that as with other most baculoviruses, GSV gene expression is temporally regulated and can be separated into early and late phases based on viral DNA replication and differential responses to the cellular RNA polymerase inhibitor, alpha-amanitin. That is, early gene expression is likely mediated by cellular RNA polymerase whereas a viral encoded or viral-modified host RNA polymerase likely mediates late viral gene expression. GSV persistent infection in vitro has been investigated using a persistently infected cell line, GSVP. GSV viral sequences and a very low level of infectious virus were detected from this normal-looking, persistently infected cell line. Co-culture of GSVP cells with another permissive cell line, Ld652Y, resulted in productive replication of GSV.
31
Vacas, Carolina Alves Malta. "The impact of government-sponsored venture capital (GSVC) on the performance of Portuguese SMEs." Master's thesis, 2018. http://hdl.handle.net/10362/36285.
Full textAbstract:
This paper studies the impact of financing by a particular set of Government-Sponsored Venture Capital (GSVC) funds, the Revitalizar VC Funds, on the performance of Portuguese SMEs measured by employment, sales and sales to total assets growth. Through an analysis using a control group of non-GSVC-backed SMEs, I conclude that in the short-term GSVC funding seems to hinder efficiency, does not seem to significantly relate to sales growth in high-tech industries and significantly relates to decreases of sales growth in low-tech industries. Contrastingly, GSVC-backed SMEs display a significantly higher performance in terms of employee growth, particularly for the high-tech industries.
32
Kakavanos, Revecca. "Immune response to enzyme replacement therapy in MPS I and GSD II patients / Revecca Kakavanos." 2006. http://hdl.handle.net/2440/22364.
Full textAbstract:
"February, 2006"Addendum attached to back page.
Bibliography: leaves 173-206.
xii, 206 leaves : ill. (chiefly col.), plates, photographs (chiefly col.) ; 30 cm.
Title page, contents and abstract only. The complete thesis in print form is available from the University Library.
Thesis (Ph.D.)--University of Adelaide, School of Paediatrics and Reproductive Health, Discipline of Paediatrics, 2006
33
Pokorná, Martina. "Evoluce způsobů určování pohlaví a genomů u šupinatých plazů (Reptilia: Squamata)." Doctoral thesis, 2011. http://www.nusl.cz/ntk/nusl-311480.
Full textAbstract:
Evolution of sex determining mechanisms in squamate reptiles (Reptilia: Squamata) Martina Pokorná Ph.D. thesis Abstract This Ph.D. thesis is focused on the evolution of sex determining mechanisms and genomes in squamate reptiles. It is based on three published articles and two manuscripts. The evolution of sex determining mechanisms, sex chromosomes and genomes, and their organisation, was studied on a wide phylogenetic scale of the whole group of squamate reptiles and some lineages of other Sauropsids, as well as on the small phylogenetic range as a detailed comparative study inside individual lineages of squamates. This thesis is based upon the use of classical cytogenetic methods, methods of molecular cytogenetic (especially fluorescent in situ hybridisation) and the results were analysed using phylogenetic approaches. The results and outputs of this study represent an important contribution to the general knowledge of the principals of sex determination and the evolution of these phenomena not only in squamate reptiles but also in the whole group of amniotes. Using the results obtained during the work on this thesis we can conclude that sex chromosomes evolved in particular lineages of amniotes independently. This origin was in some cases followed by accumulation of microsatellite sequences on sex...
34
Lee, Hyun Kyung [Verfasser]. "GSD Typ II und Typ IV : biochemische und molekulargenetische Analyse bei Patienten mit Mangel an saurer α-Glukosidase bzw. mit Branchingenzymmangel / vorgelegt von Hyun Kyung Lee." 2005. http://d-nb.info/97567708X/34.
Full text
35
Kundu, Madan Gopal. "Advanced Modeling of Longitudinal Spectroscopy Data." Thesis, 2014. http://hdl.handle.net/1805/5454.
Full textAbstract:
Indiana University-Purdue University Indianapolis (IUPUI)Magnetic resonance (MR) spectroscopy is a neuroimaging technique. It is widely used to quantify the concentration of important metabolites in a brain tissue. Imbalance in concentration of brain metabolites has been found to be associated with development of neurological impairment. There has been increasing trend of using MR spectroscopy as a diagnosis tool for neurological disorders. We established statistical methodology to analyze data obtained from the MR spectroscopy in the context of the HIV associated neurological disorder. First, we have developed novel methodology to study the association of marker of neurological disorder with MR spectrum from brain and how this association evolves with time. The entire problem fits into the framework of scalar-on-function regression model with individual spectrum being the functional predictor. We have extended one of the existing cross-sectional scalar-on-function regression techniques to longitudinal set-up. Advantage of proposed method includes: 1) ability to model flexible time-varying association between response and functional predictor and (2) ability to incorporate prior information. Second part of research attempts to study the influence of the clinical and demographic factors on the progression of brain metabolites over time. In order to understand the influence of these factors in fully non-parametric way, we proposed LongCART algorithm to construct regression tree with longitudinal data. Such a regression tree helps to identify smaller subpopulations (characterized by baseline factors) with differential longitudinal profile and hence helps us to identify influence of baseline factors. Advantage of LongCART algorithm includes: (1) it maintains of type-I error in determining best split, (2) substantially reduces computation time and (2) applicable even observations are taken at subject-specific time-points. Finally, we carried out an in-depth analysis of longitudinal changes in the brain metabolite concentrations in three brain regions, namely, white matter, gray matter and basal ganglia in chronically infected HIV patients enrolled in HIV Neuroimaging Consortium study. We studied the influence of important baseline factors (clinical and demographic) on these longitudinal profiles of brain metabolites using LongCART algorithm in order to identify subgroup of patients at higher risk of neurological impairment.
Partial research support was provided by the National Institutes of Health grants U01-MH083545, R01-CA126205 and U01-CA086368
36
Tóthová, Lucia. "Úloha steroidních hormonů při kontrole pohlavně dimorfních znaků u gekončíků (Eublepharidae)." Master's thesis, 2013. http://www.nusl.cz/ntk/nusl-323453.
Full textAbstract:
The importance of sex hormones in formation, development and regulation of sexually dimorphic behavior does not need to be stressed. However, their actual organizational and activational effects and interactions in sexual differentiation and determination are not fully understood yet. The aim of our study was to explore the effects of hormonal manipulation in eyelid-geckos (family Eublepharidae) and enlighten the role of steroid hormones in formation of sexual differences. In the first part of our work we tried to reverse sex of Yucatán banded gecko (Coleonyx elegans) by hormonal manipulation in the early embryogenesis. This species has genotypic sex determination with chromosome set X1X2Y. In reverted individuals we aimed to examine the effects of steroid hormones on sexually dimorphic traits and in case of full sexual reversion and fertility of progeny, we would search for the sex-determining gene. In the second part, we studied masculinization effects of testosterone in females of leopard gecko (Eublepharis macularius). In contrast with the Coleonyx elegans mentioned above, this species has temperature dependent sex determination, even though these two species are closely related. Experimental females were implanted with testosterone implants and therefore their testosterone levels were increased in...
37
Camilo, Joana Vargas Ferreira. "Doença de Pompe." Master's thesis, 2015. http://hdl.handle.net/10451/26948.
Full textAbstract:
Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2015A doença de Pompe (DP), também referida como deficiência da maltase ácida ou doença do armazenamento do glicogénio tipo II, é uma doença hereditária rara, de transmissão autossómica recessiva. Trata-se de uma doença de sobrecarga lisossomal (DSL), na qual ocorre a acumulação excessiva de glicogénio nos lisossomas, em consequência da deficiência na enzima lisossomal responsável pela sua degradação, a a-glucosidase ácida. A patologia está associada a uma grande heterogeneidade fenotípica, pelo que geralmente se definem dois fenótipos clínicos distintos, uma forma infantil e uma forma tardia. A aprovação da terapêutica enzimática de substituição (ERT), em 2006, associada ao desenvolvimento de novos métodos de diagnóstico, despoletou um maior interesse na doença, levando à descoberta de novos pontos-chave na fisiopatologia e à investigação de novos alvos terapêuticos. Dada a evolução da última década, nesta monografia pretende-se fazer uma atualização e compilação da informação sobre a doença de Pompe, focando a fisiopatologia, as manifestações clínicas, o processo de diagnóstico e as recomendações terapêuticas. Uma vez que se trata de uma doença rara, pretende-se ainda divulgar a patologia e contribuir para a efetivação do seu diagnóstico após o aparecimento dos primeiros sintomas e implementação da terapêutica adequada o mais precocemente possível. Por fim, é ainda abordado o caso clínico de um doente seguido no hospital de Santo António dos Capuchos, em Lisboa, através do qual se pode inferir o modo como se processa o diagnóstico e tratamento da Doença de Pompe em Portugal.