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Journal articles on the topic 'GTMA'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Bobardt, Michael, Christina M. Ramirez, Marc M. Baum, Daren Ure, Robert Foster, and Philippe A. Gallay. "The combination of the NS5A and cyclophilin inhibitors results in an additive anti-HCV inhibition in humanized mice without development of resistance." PLOS ONE 16, no. 5 (2021): e0251934. http://dx.doi.org/10.1371/journal.pone.0251934.

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We and others previously reported that the direct-acting agents (DAA) NS5A inhibitors (NS5Ai) and the host-targeting agents cyclophilin inhibitors (CypIs) inhibit HCV replication in vitro. In this study, we investigated whether the combination of NS5Ai and CypI offers a potent anti-HCV effect in vivo. A single administration of NS5Ai or CypI alone to HCV-infected humanized-mice inhibits HCV replication. The combination of NS5Ai with CypI suppresses HCV (GT1a, GT2a, GT3a and GT4a) replication in an additive manner. NS5Ai/CypI combinations provide a statistically more profound anti-HCV inhibitio

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Dolan, Stephen K., Tobias Bock, Vanessa Hering, et al. "Structural, mechanistic and functional insight into gliotoxin bis -thiomethylation in Aspergillus fumigatus." Open Biology 7, no. 2 (2017): 160292. http://dx.doi.org/10.1098/rsob.160292.

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Gliotoxin is an epipolythiodioxopiperazine (ETP) class toxin, contains a disulfide bridge that mediates its toxic effects via redox cycling and is produced by the opportunistic fungal pathogen Aspergillus fumigatus . Self-resistance against gliotoxin is effected by the gliotoxin oxidase GliT, and attenuation of gliotoxin biosynthesis is catalysed by gliotoxin S -methyltransferase GtmA. Here we describe the X-ray crystal structures of GtmA-apo (1.66 Å), GtmA complexed to S -adenosylhomocysteine (1.33 Å) and GtmA complexed to S -adenosylmethionine (2.28 Å), providing mechanistic insights into th

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Zhuang, Zheng-Yun, Chang-Ching Lin, Chih-Yung Chen, and Chia-Rong Su. "Rank-Based Comparative Research Flow Benchmarking the Effectiveness of AHP–GTMA on Aiding Decisions of Shredder Selection by Reference to AHP–TOPSIS." Applied Sciences 8, no. 10 (2018): 1974. http://dx.doi.org/10.3390/app8101974.

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The AHP–GTMA (analytic hierarchy process and graph theory and matrix approach) has been applied to select the best paper shredder before a company was making a bulk purchase order. However, there is a question as to whether one such relatively recent approach is effective to aid the selection decision problems in industrial/commercial practice. In this paper, a novel multi-measure, rank-based comparative research flow is proposed. The real decision problem case mentioned above is solved using the AHP–GTMA and the AHP–TOPSIS methods, respectively, with relevant datasets sourced. Several measure

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Sepúlveda-Crespo, Daniel, Camilla Volpi, Rafael Amigot-Sánchez, et al. "Sustained Long-Term Decline in Anti-HCV Neutralizing Antibodies in HIV/HCV-Coinfected Patients Five Years after HCV Therapy: A Retrospective Study." Pharmaceuticals 17, no. 9 (2024): 1152. http://dx.doi.org/10.3390/ph17091152.

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Abstract: Background: This study evaluated titers and amplitudes of anti-E2 antibodies (anti-E2-Abs) and neutralizing antibodies against hepatitis C virus (HCV; anti-HCV-nAbs) in HIV/HCV-coinfected individuals over five years after successful HCV treatment completion. Methods: We retrospectively analyzed 76 HIV/HCV-coinfected patients achieving sustained virologic response post-HCV treatment. Plasma levels of anti-E2-Abs and anti-HCV-nAbs against five HCV genotypes (Gt1a, Gt1b, Gt2a, Gt3a, and Gt4a) were determined using ELISA and microneutralization assays, respectively. Statistical analyses

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Monica, Jatavathu. "Integrating AHP and GTMA for Enhanced Multi-Criteria Decision Making in Logistics Provider Selection." International Journal for Research in Applied Science and Engineering Technology 12, no. 9 (2024): 924–33. http://dx.doi.org/10.22214/ijraset.2024.64294.

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The selection of logistics providers is a critical task for organizations aiming to enhance their supply chain performance and maintain a competitive edge. This paper proposes an integrated approach that combines the Analytic Hierarchy Process (AHP) and Graph-Theoretic Matrix Approach (GTMA) for effective multi-criteria decision-making (MCDM) in the selection of logistics providers. AHP is widely used for evaluating criteria and alternatives based on pairwise comparisons, while GTMA enhances decision-making by incorporating complex interdependencies among criteria. The integrated AHPGTMA appro

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Gumaida, Bassam, Chang Liu, and Juan Luo. "GTMA: Localization in Wireless Sensor Network Based a Group of Tri-Mobile Anchors." Journal of Computational and Theoretical Nanoscience 14, no. 1 (2017): 847–57. http://dx.doi.org/10.1166/jctn.2017.6287.

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Sensors positioning with high accuracy is a fundamental stone in Wireless Sensor Networks (WSNs). In outdoor environment which is hostile and unreachable, mobile anchors method is considered as an appropriate solution for locating unknown nodes. In this case, the key problems are the trajectory mapping and the needed number of mobile anchors. These mobile anchors should travel along the trajectory in order to determine the positions of unknown nodes with minimum localization error. In this paper, a localization algorithm named Group of Tri-Mobile Anchors (GTMA) is proposed, which is based on a

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Tuljak-Suban, Danijela, and Patricija Bajec. "Integration of AHP and GTMA to Make a Reliable Decision in Complex Decision-Making Problems: Application of the Logistics Provider Selection Problem as a Case Study." Symmetry 12, no. 5 (2020): 766. http://dx.doi.org/10.3390/sym12050766.

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When solving a Multi-Criteria Decision-Making problem of any degree of complexity, many researchers rely on the analytic hierarchy process (AHP). To consider mutual connections between criteria and clusters at the same level and not only the hierarchical structure between criteria and subcriteria, researchers often upgrade from AHP to the Analytic Network Process (ANP), which also examines the interdependency of criteria. However, the ANP method requires a large number of pairwise comparisons. In the case of a complex decision-making problem, the authors of this paper suggest upgrading the AHP

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Liu, Mengping, Maria Tuttle, Min Gao, and Julie A. Lemm. "Potency and Resistance Analysis of Hepatitis C Virus NS5B Polymerase Inhibitor BMS-791325 on All Major Genotypes." Antimicrobial Agents and Chemotherapy 58, no. 12 (2014): 7416–23. http://dx.doi.org/10.1128/aac.03851-14.

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ABSTRACTBMS-791325 is a hepatitis C virus (HCV) inhibitor binding to the thumb domain of the NS5B RNA-dependent RNA polymerase. BMS-791325 is well characterized in genotype 1 (GT1) and exhibits good inhibitory activity (50% effective concentration [EC50], <10 nM) against hybrid replicons containing patient NS5B sequences from GT3a, -4a, and -5a while potency against GT2 is significantly reduced (J. A. Lemm et al., Antimicrob. Agents Chemother. 58:3485–3495, 2014, doi:http://dx.doi.org/10.1128/AAC.02495-13). BMS-791325 potency against GT6a hybrid replicons is more variable, with two of three

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Herlihy, Koleen J., Joanne P. Graham, Robert Kumpf, Amy K. Patick, Rohit Duggal, and Stephanie T. Shi. "Development of Intergenotypic Chimeric Replicons To Determine the Broad-Spectrum Antiviral Activities of Hepatitis C Virus Polymerase Inhibitors." Antimicrobial Agents and Chemotherapy 52, no. 10 (2008): 3523–31. http://dx.doi.org/10.1128/aac.00533-08.

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ABSTRACT To address the need for broad-spectrum antiviral activity characterization of hepatitis C virus (HCV) polymerase inhibitors, we created a panel of intergenotypic chimeric replicons containing nonstructural (NS) protein NS5B sequences from genotype 2b (GT2b), GT3a, GT4a, GT5a, and GT6a HCV isolates. Viral RNA extracted from non-GT1 HCV patient plasma was subjected to reverse transcription. The NS5B region was amplified by nested PCR and introduced into the corresponding region of the GT1b (Con-1) subgenomic reporter replicon by Splicing by Overlap Extension (SOEing) PCR. Stable cell li

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Minosse, Claudia, Leonidas Salichos, Chiara Taibi, et al. "Phylogenetic and Phylodynamic Analyses of HCV Strains Circulating among Patients Using Injectable Drugs in Central Italy." Microorganisms 9, no. 7 (2021): 1432. http://dx.doi.org/10.3390/microorganisms9071432.

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Approximately 71 million people worldwide are infected with the hepatitis C virus (HCV). Injectable drug use represents the most common route of transmission in Europe and other developed countries. We studied the molecular characteristics of the HCV infection among mono-infected people who used drugs (PWUD) in Italy. Among 208 PWUD with anti-HCV antibodies, 101 (48.6%) were HCV RNA-positive, the majority (47%) were infected with the HCV genotype (Gt)1a, followed by Gt3a (34.9%), Gt4 (9.1%), Gt1b (4.5%), and Gt2 (4.5%). Bayesian phylogenetic analyses of clustered HCV NS5B sequences from 66 HCV

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Ahlén, Gustaf, Antony Chen, Barbara Roe, et al. "Limited effect on NS3–NS4A protein cleavage after alanine substitutions within the immunodominant HLA-A2-restricted epitope of the hepatitis C virus genotype 3a non-structural 3/4A protease." Journal of General Virology 93, no. 8 (2012): 1680–86. http://dx.doi.org/10.1099/vir.0.043745-0.

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It has been well established that immunological escape mutations within the hepatitis C virus genotype (gt) 1a non-structural (NS) 3/4A protease are partly prevented by a reduction in viral protease fitness. Surprisingly little is known about whether similar mutations affect proteases from other genotypes. In the present study, we assessed both the HLA-A2-restricted CTL response and gt3a NS3/4A protease fitness. Similar to gt1, the 1073–1081 epitope was immunodominant within the gt3a-specific HLA-A2-restricted CTL response, despite sequence similarity of only 56 % between the gt1a and gt3a gen

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Prabakaran R. "Diagnosis of Type-2 Diabetes using Multi-Criteria Decision-Making Techniques with Diverse Operators." Communications on Applied Nonlinear Analysis 32, no. 9s (2025): 1043–72. https://doi.org/10.52783/cana.v32.4111.

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This study applies multi-criteria decision-making (MCDM) techniques to identify and evaluate the risk factors associated with Type 2 diabetes mellitus (T2DM). By leveraging advanced MCDM approaches, the study aims to enhance the decision-making process for T2DM diagnosis and management. The primary objective of this study is to develop a comprehensive framework for ranking and prioritizing various risk factors contributing to the onset and progression of T2DM. The study also aims to compare different MCDM techniques and aggregation operators to provide a deeper understanding of the influence o

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Malik, Sana, Aradhana Kumari, and Saurabh Agrawal. "Selection of Locations of Collection Centers for Reverse Logistics Using GTMA." Materials Today: Proceedings 2, no. 4-5 (2015): 2538–47. http://dx.doi.org/10.1016/j.matpr.2015.07.199.

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de Castro, Patrícia Alves, Ana Cristina Colabardini, Maísa Moraes, et al. "Regulation of gliotoxin biosynthesis and protection in Aspergillus species." PLOS Genetics 18, no. 1 (2022): e1009965. http://dx.doi.org/10.1371/journal.pgen.1009965.

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Aspergillus fumigatus causes a range of human and animal diseases collectively known as aspergillosis. A. fumigatus possesses and expresses a range of genetic determinants of virulence, which facilitate colonisation and disease progression, including the secretion of mycotoxins. Gliotoxin (GT) is the best studied A. fumigatus mycotoxin with a wide range of known toxic effects that impair human immune cell function. GT is also highly toxic to A. fumigatus and this fungus has evolved self-protection mechanisms that include (i) the GT efflux pump GliA, (ii) the GT neutralising enzyme GliT, and (i

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Kumar, Narender, Girish Kumar, and Rajesh Kr Singh. "Analysis of barriers intensity for investment in big data analytics for sustainable manufacturing operations in post-COVID-19 pandemic era." Journal of Enterprise Information Management 35, no. 1 (2021): 179–213. http://dx.doi.org/10.1108/jeim-03-2021-0154.

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PurposeThe study presents various barriers to adopt big data analytics (BDA) for sustainable manufacturing operations (SMOs) post-coronavirus disease (COVID-19) pandemics. In this study, 17 barriers are identified through extensive literature review and experts’ opinions for investing in BDA implementation. A questionnaire-based survey is conducted to collect responses from experts. The identified barriers are grouped into three categories with the help of factor analysis. These are organizational barriers, data management barriers and human barriers. For the quantification of barriers, the gr

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Goyal, Sanjeev, and Sandeep Grover. "Manufacturing system’s effectiveness measurement by using combined approach of ANP and GTMA." International Journal of System Assurance Engineering and Management 4, no. 4 (2012): 404–23. http://dx.doi.org/10.1007/s13198-012-0129-2.

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Karnan, Balamurugan, and Arunkarthikeyan Kuppusamy. "Graph Theory and Matrix Approach for Machinability Enhancement of Cryogenic Treated Cobalt Bonded Tungsten Carbide Inserts." International Journal of Heat and Technology 39, no. 4 (2021): 1372–82. http://dx.doi.org/10.18280/ijht.390438.

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Cryogenic treatment is a sustainable manufacturing process preferred to improve the properties of the material. In the present study, the effect of cryo treated tungsten carbide cobalt bonded insert (WC-Co) measured in terms of tool life and surface finish on dry turning on high strength AISI4340 steel at different machine parametric conditions. The observations of Untreated (UT) and Deep Cryo Treated (DCT) inserts were compared. Formation and the distribution of eta phase carbides are verified by Scanning Electron Micrograph (SEM). The DCT insert shows a reduction in 27.27% tool wear with an

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18

Jain, Vineet, and Tilak Raj. "Modelling and analysis of FMS productivity variables by ISM, SEM and GTMA approach." Frontiers of Mechanical Engineering 9, no. 3 (2014): 218–32. http://dx.doi.org/10.1007/s11465-014-0309-7.

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Jain, Vineet, and Tilak Raj. "Modeling and analysis of FMS performance variables by ISM, SEM and GTMA approach." International Journal of Production Economics 171 (January 2016): 84–96. http://dx.doi.org/10.1016/j.ijpe.2015.10.024.

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Bharat, Singh1 &. Mr. Dharamvir Dixit2. "APPLICATION OF FUZZY GTMA (GRAPH THEORY) APPROACH FOR QUALITY ENHANCEMENT IN AN INDUSTRY." GLOBAL JOURNAL OF ENGINEERING SCIENCE AND RESEARCHES 5, no. 8 (2018): 169–73. https://doi.org/10.5281/zenodo.1344372.

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The graph theoretic approach where interaction among identified key performance attribute is represented through digraph matrix model and a multinomial. Graph theoretic approach has been adopted for evaluation and selection material. The authors also considered research papers on graph theoretic methodology and mentioned the factors used by different researchers. During the application of graph theoretic approach a digraph of characteristics which contributes to quality of products. The essence of fuzzy theory is the process of identifying the graph theory approach. The graph theory approach i

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Sadioura, Amritpal Singh, Rupinder Singh, and Harwinder Singh. "Machinability Index Evaluation: A Case Study of Carbide Inserts." Applied Mechanics and Materials 330 (June 2013): 86–90. http://dx.doi.org/10.4028/www.scientific.net/amm.330.86.

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The selection of carbide insert on the basis of performance measuring parameters is amulti-attribute decision making problem. This proposed work demonstrates a methodology to evaluate the machinability of the selected turning operation by using graph theory and matrix methods. The qualitative values of attributes are obtained by measuring the process attributes. The fuzzy score has been used to convert intangible factors to crisp scores and then graph theoretic approach has been applied to calculate the single numerical machinability index for ranking among the insert alternatives. Permanent f

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Chand, Ramesh, and M. K. Gupta. "Estimation of Dimensional Deviation of Parts Printed in Different Orientations on Multi Jet Printer." Prabha Materials Science Letters 3, no. 1 (2024): 46–59. http://dx.doi.org/10.33889/pmsl.2024.3.1.003.

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The study was primarily concerned with the dimensional deviation for the part produced in the various alignments A, B, C, & D and selecting the orientation or alignments through the least dimensional deviation. In this work, the part is lying on the base (A), the long edge (B), and the short edge (C), and the part is inclined at 45 degrees (D) to the surface of the base plate. Created the components in a variety of orientations using a multi-jet printer. Further, using experimental data (change in length, width, height and diameter), the model has been developed with a regression-based imp

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Popping, Stephanie, Valeria Cento, Carole Seguin-Devaux, et al. "The European Prevalence of Resistance Associated Substitutions among Direct Acting Antiviral Failures." Viruses 14, no. 1 (2021): 16. http://dx.doi.org/10.3390/v14010016.

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Background: Approximately 71 million people are still in need of direct-acting antiviral agents (DAAs). To achieve the World Health Organization Hepatitis C elimination goals, insight into the prevalence and influence of resistance associated substitutions (RAS) is of importance. Collaboration is key since DAA failure is rare and real-life data are scattered. We have established a European collaboration, HepCare, to perform in-depth analysis regarding RAS prevalence, patterns, and multiclass occurrence. Methods: Data were extracted from the HepCare cohort of patients who previously failed DAA

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Vookoti, Uma Sai Vara Prasad, Venkata Rao K., and Satish Kumar P. "Optimization of machining characteristics during helical milling of AISI D2 steel considering chip geometry." Independent Journal of Management & Production 13, no. 2 (2022): 750–70. http://dx.doi.org/10.14807/ijmp.v13i2.1617.

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Helical milling is one of the high-performance and high-quality hole manufacturing activities with strong prospects for the automotive and aerospace industries. Literature suggests chip geometry plays a significant role in optimizing machining operations. In the present study, a mechanistic approach is used to estimate the chip geometry, cutting force and power/energy consumption concerning the tool rotation angle. Experiments are conducted at different levels of spindle rotational speed, cutter orbital speed and axial depth of cuts using 8 and 10 mm diameter mill cutters. Experimental results

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Yasir, Muhammad, Abdoul Jelil Niang, Md Sakaouth Hossain, Qamar Ul Islam, Qian Yang, and Yuhang Yin. "Ranking Ship Detection Methods Using SAR Images Based on Machine Learning and Artificial Intelligence." Journal of Marine Science and Engineering 11, no. 10 (2023): 1916. http://dx.doi.org/10.3390/jmse11101916.

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We aimed to improve the performance of ship detection methods in synthetic aperture radar (SAR) images by utilizing machine learning (ML) and artificial intelligence (AI) techniques. The maritime industry faces challenges in collecting precise data due to constantly changing sea conditions and weather, which can affect various maritime operations, such as maritime security, rescue missions, and real-time monitoring of water boundaries. To overcome these challenges, we present a survey of AI- and ML-based techniques for ship detection in SAR images that provide a more effective and reliable way

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Morsica, Giulia, Riccardo Vercesi, Hamid Hasson, Emanuela Messina, Caterina Uberti-Foppa, and Sabrina Bagaglio. "Compartmentalization of Resistance-Associated Substitutions in HIV/HCV-Infected Patients: Possible Correlation with Infecting HCV Genotype." Viruses 13, no. 8 (2021): 1486. http://dx.doi.org/10.3390/v13081486.

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Resistance-associated substitutions (RASs) may exist prior to treatment and contribute to the failure of treatment with direct-acting antivirals (DAAs). As the major site of HCV replication, naturally occurring variants with RASs may segregate into the liver. In the present study, we performed viral population sequencing to retrospectively investigate the NS3 and NS5A RAS profiles in 34 HIV/HCV coinfected patients naïve to anti-HCV treatment who underwent diagnostic liver biopsy between 2000 and 2006 and had liver and plasma samples available. Sixteen were infected by HCV genotype (GT) 1a, 11

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Bagaglio, Sabrina, Hamid Hasson, Luca Peano, et al. "A Prospective Italian Study on Baseline NS3 and NS5A Resistance to Direct-Acting Antivirals in a Real-World Setting of HIV-1/HCV Coinfected Patients and Association with Treatment Outcome." Viruses 12, no. 3 (2020): 269. http://dx.doi.org/10.3390/v12030269.

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We prospectively evaluated the frequency of natural resistance-associated substitutions (RASs) in the NS3 and NS5A regions according to different HCV genotypes and their possible effect on treatment outcome in HIV-1/HCV patients treated with direct-acting antivirals (DAAs). Baseline RASs in the NS3 and NS5A domains were investigated in 62 HIV-1/HCV patients treated with DAAs: 23 patients harbored HCV-GT1a, 26 harbored GT3a, and 13 harbored GT4d. A higher occurrence of RASs was found in the NS3 domain within GT1a (13/23) than GT3a (0/26) or GT4d (2/13). With regard to treatment outcome, NS3 RAS

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McNaughton, Anna L., Iain Dugald Cameron, Elizabeth B. Wignall-Fleming, et al. "Spatiotemporal Reconstruction of the Introduction of Hepatitis C Virus into Scotland and Its Subsequent Regional Transmission." Journal of Virology 89, no. 22 (2015): 11223–32. http://dx.doi.org/10.1128/jvi.02106-15.

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ABSTRACTA more comprehensive understanding of hepatitis C virus (HCV) transmission dynamics could facilitate public health initiatives to reduce the prevalence of HCV in people who inject drugs. We aimed to determine how HCV sequences entered and spread throughout Scotland and to identify transmission hot spots. A Scottish data set with embedded demographic data was created by sequencing the NS5B of 125 genotype 1a (Gt1a) samples and 166 Gt3a samples and analyzed alongside sequences from public databases. Applying Bayesian inference methods, we reconstructed the global origin and local spatiot

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Rao, K. Venkata, P. B. G. S. N. Murthy, and K. P. Vidhu. "Assignment of weightage to machining characteristics to improve overall performance of machining using GTMA and utility concept." CIRP Journal of Manufacturing Science and Technology 18 (August 2017): 152–58. http://dx.doi.org/10.1016/j.cirpj.2016.12.001.

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Brelle, Laura, Estelle Renard, and Valerie Langlois. "Antioxidant Network Based on Sulfonated Polyhydroxyalkanoate and Tannic Acid Derivative." Bioengineering 8, no. 1 (2021): 9. http://dx.doi.org/10.3390/bioengineering8010009.

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A novel generation of gels based on medium chain length poly(3-hydroxyalkanoate)s, mcl-PHAs, were developed by using ionic interactions. First, water soluble mcl-PHAs containing sulfonate groups were obtained by thiol-ene reaction in the presence of sodium-3-mercapto-1-ethanesulfonate. Anionic PHAs were physically crosslinked by divalent inorganic cations Ca2+, Ba2+, Mg2+ or by ammonium derivatives of gallic acid GA-N(CH3)3+ or tannic acid TA-N(CH3)3+. The ammonium derivatives were designed through the chemical modification of gallic acid GA or tannic acid TA with glycidyl trimethyl ammonium c

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Brelle, Laura, Estelle Renard, and Valerie Langlois. "Antioxidant Network Based on Sulfonated Polyhydroxyalkanoate and Tannic Acid Derivative." Bioengineering 8, no. 1 (2021): 9. http://dx.doi.org/10.3390/bioengineering8010009.

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A novel generation of gels based on medium chain length poly(3-hydroxyalkanoate)s, mcl-PHAs, were developed by using ionic interactions. First, water soluble mcl-PHAs containing sulfonate groups were obtained by thiol-ene reaction in the presence of sodium-3-mercapto-1-ethanesulfonate. Anionic PHAs were physically crosslinked by divalent inorganic cations Ca2+, Ba2+, Mg2+ or by ammonium derivatives of gallic acid GA-N(CH3)3+ or tannic acid TA-N(CH3)3+. The ammonium derivatives were designed through the chemical modification of gallic acid GA or tannic acid TA with glycidyl trimethyl ammonium c

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Jatavallabhula, Jagadesh Kumar, Vaddi Venkata Satyanarayana, and Vasudeva Rao Veeredhi. "Multi-Attribute Optimization of a Ceramic Coating on Super Duplex Stainless Steel Using Hybrid Taguchi – GTMA – Utility Technique." International Review of Mechanical Engineering (IREME) 18, no. 8 (2024): 429. https://doi.org/10.15866/ireme.v18i8.24959.

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Giri, Puspendu, Somnath Paul, and Bijoy Krishna Debnath. "A fuzzy Graph Theory and Matrix Approach (fuzzy GTMA) to select the best renewable energy alternative in India." Applied Energy 358 (March 2024): 122582. http://dx.doi.org/10.1016/j.apenergy.2023.122582.

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Beverlley, Madzikanda, Li Cai, and Tang Dabuo Francis. "Foreign Entrepreneur Success in China: The Role of Entrepreneurial Cognition in Opportunity Recognition." International Journal of Management, Accounting and Economics 9, no. 6 (2022): 322–53. https://doi.org/10.5281/zenodo.6977438.

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There is a huge opportunity for foreign entrepreneurs to enter the Chinese market. They have noted that the market is difficult to enter and complex to navigate. This study contributes towards filling this gap by identifying the critical success factors for foreigners in China, basing on entrepreneurial cognition and opportunity recognition theories. 128 entrepreneurs in China were surveyed through semi-structured interviews. Their responses were collated and analyzed using graph theoretic matrix approach to identify and rank the factors with the most influence on their business success. The f

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Wen, Lingtao, Zebo Qiao, and Jun Mo. "Modern technology, artificial intelligence, machine learning and internet of things based revolution in sports by employing graph theory matrix approach." AIMS Mathematics 9, no. 1 (2023): 1211–26. http://dx.doi.org/10.3934/math.2024060.

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<abstract> <p>The sports industry is gaining popularity with time and all the countries are investing a lot of money for fame and entertainment around the world. To ensure the high quality of sports, modern techniques such as machine learning (ML), artificial intelligence (AI) and the Internet of Things (IoT) are playing a very optimistic role. Various IoT-grounded smart sensors are implemented with integration in AI and ML for the safety and high performance of the players. Based on the numerous applications of modern technologies, it is very convenient to capture different body m

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Mei, Yong-yu, You-ming Chen, Yuan-kai Wu, Xiao-hong Zhang, and Wen-xiong Xu. "Efficacy and Safety of Sofosbuvir-Based Direct-Acting Antiviral Agents Treatment for Patients with Genotype 3/6 Hepatitis C Virus Infection." Canadian Journal of Gastroenterology and Hepatology 2020 (October 31, 2020): 1–8. http://dx.doi.org/10.1155/2020/8872120.

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Aims. The aim is to evaluate the efficacy and safety of Sofosbuvir- (SOF-) based direct-acting antiviral agents (DAAs) treatment for patients with genotype (GT) 3/6 hepatitis C virus (HCV) infection. Methods. Patients infected with GT 3/6 HCV and treated with SOF-based DAAs were enrolled in this prospective, open, single-center, and real-world study. Drugs included Sofosbuvir (SOF), Velpatasvir (VEL), Daclatasvir (DCV), and Ribavirin (RBV). The treatment regimens included SOF + RBV for 24 weeks, SOF + DCV ± RBV for 12/24 weeks, and SOF/VEL ± RBV for 12 weeks. Results. A total of 54 patients we

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Owens, Rebecca A., Grainne O'Keeffe, Elizabeth B. Smith, et al. "Interplay between Gliotoxin Resistance, Secretion, and the Methyl/Methionine Cycle in Aspergillus fumigatus." Eukaryotic Cell 14, no. 9 (2015): 941–57. http://dx.doi.org/10.1128/ec.00055-15.

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ABSTRACTMechanistic studies on gliotoxin biosynthesis and self-protection inAspergillus fumigatus, both of which require the gliotoxin oxidoreductase GliT, have revealed a rich landscape of highly novel biochemistries, yet key aspects of this complex molecular architecture remain obscure. Here we show that anA. fumigatusΔgliAstrain is completely deficient in gliotoxin secretion but still retains the ability to efflux bisdethiobis(methylthio)gliotoxin (BmGT). This correlates with a significant increase in sensitivity to exogenous gliotoxin because gliotoxin trapped inside the cell leads to (i)

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Brahmeswara Rao, D., K. Venkata Rao, and A. Gopala Krishna. "A hybrid approach to multi response optimization of micro milling process parameters using Taguchi method based graph theory and matrix approach (GTMA) and utility concept." Measurement 120 (May 2018): 43–51. http://dx.doi.org/10.1016/j.measurement.2018.02.005.

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Saeed, M., Sahrish Mahmood, and Hina Taufeeq. "A Consistent Hybrid of Analytical Hierarchy Process (AHP) and Graph Theory Matrix Approach (GTMA) with Application to Selection of PET scan Machine Problem for Cancer Hospital." International Journal of Computer Applications 181, no. 16 (2018): 42–48. http://dx.doi.org/10.5120/ijca2018917827.

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Levander, Sepideh, Fredrik Holmström, Lars Frelin, et al. "Immune-mediated effects targeting hepatitis C virus in a syngeneic replicon cell transplantation mouse model." Gut 67, no. 8 (2017): 1525–35. http://dx.doi.org/10.1136/gutjnl-2016-313579.

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ObjectiveHCV is characterised by its ability to establish chronic infection in hepatocytes and to replicate in the presence of an inflammation. We mimicked this situation in vivo in immune-competent mice by syngeneic transplantation of HCV replicon-containing mouse hepatoma cells.DesignA total of 5 million H-2b positive Hep56.1D cells, carrying a subgenomic genotype (gt) 2a replicon (HCV replicon cells) or stably expressing comparable levels of the HCV NS3/4A protease/helicase complex (NS3/4A hepatoma cells), were injected subcutaneously into syngeneic H-2b-restricted mice. Kinetics of tumour

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Giri, Puspendu, Somnath Paul, and Bijoy Krishna Debnath. "A hybrid graph-theoretic solution of Delphi and graph theory matrix approach (GTMA) to the challenges of sustainable lithium-ion battery (LIB) supply chains in electric vehicles in India." Journal of Energy Storage 97 (September 2024): 112702. http://dx.doi.org/10.1016/j.est.2024.112702.

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Narimatsu, Masahiro, Yuichiro Noiri, Shousaku Itoh, Nobuo Noguchi, Takashi Kawahara, and Shigeyuki Ebisu. "Essential Role for the gtfA Gene Encoding a Putative Glycosyltransferase in the Adherence of Porphyromonas gingivalis." Infection and Immunity 72, no. 5 (2004): 2698–702. http://dx.doi.org/10.1128/iai.72.5.2698-2702.2004.

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ABSTRACT Porphyromonas gingivalis, an oral bacterium, might play a role in the pathogenesis or progression of adult periodontitis. In this study, we isolated from P. gingivalis a putative glycosyltransferase gene, designated gtfA, which had a consensus domain for glycosyltransferase in its N terminus. GtfA consisted of 248 amino acids and its predicted molecular mass was 28 kDa; however, as the molecular mass of endogenous GtfA protein was around 40 kDa, this suggested that GtfA had undergone some posttranslational modifications. To reveal the role of the gtfA gene in P. gingivalis, we establi

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Mukhayani, Feri, Eko Sri Kunarti, Yuichi Kamiya, and Nuryono Nuryono. "Preparation and Characterization of Magnetic Material/Chitosan Composite Modified with Glycidyl-Trimethylammonium Chloride." Indonesian Journal of Chemistry 24, no. 2 (2024): 444. http://dx.doi.org/10.22146/ijc.88758.

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Glycidyl-trimethylammonium chloride (GTMAC) containing quaternary ammonium (QA) groups is commonly used as a base catalyst for any organic reaction. This research prepared a novel composite of GTMAC attached to chitosan-coated magnetic material (MM/Chi/GTMAC) using a precipitation method. The effect of chitosan and GTMAC contents on MM/chi/GTMAC properties was studied, where the chitosan content varied from 0, 0.3, 0.5, 1.0, and 3.0 mol, and GTMAC varied from 0, 0.3, 0.8, 1.0, 1.5, and 3 mL with the constant mass of MM (0.4640 g). The physicochemical and morphological properties were character

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Kralj, S., G. H. van Geel-Schutten, H. Rahaoui та ін. "Molecular Characterization of a Novel Glucosyltransferase from Lactobacillus reuteri Strain 121 Synthesizing a Unique, Highly Branched Glucan with α-(1→4) and α-(1→6) Glucosidic Bonds". Applied and Environmental Microbiology 68, № 9 (2002): 4283–91. http://dx.doi.org/10.1128/aem.68.9.4283-4291.2002.

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ABSTRACT Lactobacillus reuteri strain 121 produces a unique, highly branched, soluble glucan in which the majority of the linkages are of the α-(1→4) glucosidic type. The glucan also contains α-(1→6)-linked glucosyl units and 4,6-disubstituted α-glucosyl units at the branching points. Using degenerate primers, based on the amino acid sequences of conserved regions from known glucosyltransferase (gtf) genes from lactic acid bacteria, the L. reuteri strain 121 glucosyltransferase gene (gtfA) was isolated. The gtfA open reading frame (ORF) was 5,343 bp, and it encodes a protein of 1,781 amino aci

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Trinanda Putra, Zahril, Aristiono Nugroho, and Ahmad Nashih Luthfi. "Peran GTRA dalam Pelaksanaan Reforma Agraria di Kabupaten Lampung Tengah." Widya Bhumi 1, no. 1 (2021): 65–85. http://dx.doi.org/10.31292/wb.v1i1.10.

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The implementation of agrarian reform to date has not been maximized due to the existence of sectoral egos and lack of coordination between related sectors / ministries. The institutional formation of the GTRA is expected to be able to unite across sectors of the relevant ministries / institutions. In Central Lampung Regency there are many land issues on HGU land and transmigration land which will later become the priority location of the Agrarian Reform Land (TORA). The Central Lampung BPN target in 2020 as many as 3,000 plots of land will be distributed to the public. It is hoped that the ex

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Kralj, S., G. H. van Geel-Schutten, M. J. E. C. van der Maarel, and L. Dijkhuizen. "Biochemical and molecular characterization of Lactobacillus reuteri 121 reuteransucrase." Microbiology 150, no. 7 (2004): 2099–112. http://dx.doi.org/10.1099/mic.0.27105-0.

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Lactobacillus reuteri strain 121 uses sucrose for synthesis of a unique, soluble glucan (‘reuteran’) with mainly α-(1→4) glucosidic linkages. The gene (gtfA) encoding this glucansucrase enzyme had previously been characterized. Here, a detailed biochemical and molecular analysis of the GTFA enzyme is presented. This is believed to be the first report describing reuteransucrase enzyme kinetics and the oligosaccharides synthesized with various acceptors. Alignments of the GTFA sequence with glucansucrases from Streptococcus and Leuconostoc identified conserved amino-acid residues in the catalyti

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Cuadrado-Godia, Elisa, Saurabh K. Srivastava, Luca Saba, et al. "Geometric Total Plaque Area Is an Equally Powerful Phenotype Compared With Carotid Intima-Media Thickness for Stroke Risk Assessment: A Deep Learning Approach." Journal for Vascular Ultrasound 42, no. 4 (2018): 162–88. http://dx.doi.org/10.1177/1544316718806421.

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Currently, carotid intima-media thickness (cIMT) and geometric total plaque area (gTPA) are computed manually and thus are tedious and prone to interobserver and intraobserver variabilities. This study presents an intelligence-based automated deep learning (DL)–based technique for carotid wall interface detection, cIMT, and lumen diameter (LD) measurements, followed by a 3D cylindrical approach for TPA measurement. The observers were used for manual tracings of which were then used for the design of two DL-based systems. The DL boundaries for inner lumen wall and outer interadventitial borders

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Sopyan, Amalia Arofah Puji, and Eliana Sidipurwanty. "Mengurai Kompleksitas Pemberdayaan Tanah Masyarakat: Pelajaran dari Gugus Tugas Reforma Agraria di Bangka Tengah." Tunas Agraria 7, no. 2 (2024): 201–20. http://dx.doi.org/10.31292/jta.v7i2.296.

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Community Land Empowerment (PTM) and the role of the Agrarian Reform Task Force (GTRA) are important to overcome inequality in land access in Indonesia. However, improving coordination between sectors is necessary to enhance the effectiveness of PTM implementation. This research aims to determine the role of GTRA in implementing PTM and various developments in access arrangements in Central Bangka Regency, as well as the problems and solutions faced. The research uses qualitative methods by collecting data through document reviews, interviews, and literature studies, as well as qualitative des

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Simon, Karl-Georg, Yvonne Serfert, Peter Buggisch, et al. "Veränderungen der Hepatitis-C-Virus-Genotyp-1a/1b-Verteilung zwischen 2004 und 2018 in Deutschland – eine Analyse von 17093 Patienten aus verschiedenen Real-World-Registern." Zeitschrift für Gastroenterologie 59, no. 03 (2021): 241–49. http://dx.doi.org/10.1055/a-1332-2214.

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Zusammenfassung Einleitung Der Hepatitis C Genotyp 1 ist der häufigste Genotyp in West- und Zentraleuropa. In dieser Arbeit werden die Veränderungen der Baselinecharakteristika von 17 093 HCV-Patienten mit Genotyp 1a/1b, die im Zeitraum 2004–2018 in Deutschland antiviral therapiert wurden, analysiert. Es wurden insgesamt 5 Zeiträume betrachtet: (i) 2004–2007, (ii) 2008–2010, (iii) 2010–2013, (iv) 2014–2016, (v) 2017–2018. Methoden Die vorliegende Analyse basiert auf 5 deutschlandweit durchgeführten nicht-interventionellen Registern und umfasst Daten von Patienten, die mit dem HCV-GT1a und HCV-

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Resti, Farah Ananda, and Harvini Wulansari. "Peran Gugus Tugas Reforma Agraria Mewujudkan Kampung Reforma Agraria." Tunas Agraria 5, no. 2 (2022): 94–110. http://dx.doi.org/10.31292/jta.v5i2.178.

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Reforma agraria merupakan proses penataan kembali struktur penguasaan, pemilikan, penggunaan, dan pemanfaatan tanah yang lebih berkeadilan. Dalam menjalankan pelaksanaan reforma agraria maka dibentuklah Tim Gugus Tugas Reforma Agraria (GTRA). Penelitian ini bertujuan untuk memahami peran GTRA dalam menyukseskan kegiatan reforma agraria serta kendala yang dihadapi dalam pelaksanaan kegiatan GTRA di Kabupaten Seruyan Provinsi Kalimantan Tengah. Metode penelitian yang digunakan adalah penelitian kualitatif dengan pendekatan deskriptif. Data yang diperoleh merupakan hasil telaah yang berasal dari

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