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Relevant bibliographies by topics / GTP17

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Journal articles
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Academic literature on the topic 'GTP17'

Author: Grafiati

Published: 4 June 2021

Last updated: 14 February 2022

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Journal articles on the topic "GTP17"

1

Walter, J. "'The Pooremans Joy and the Gentlemans Plague': A Lincolnshire Libel and the Politics of Sedition in Early Modern England." Past & Present 203, no. 1 (2009): 29–67. http://dx.doi.org/10.1093/pastj/gtp017.

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2

Wang, Quan, Yanli Xu, Andrei V. Perepelov, et al. "Characterization of the CDP-2-Glycerol Biosynthetic Pathway in Streptococcus pneumoniae." Journal of Bacteriology 192, no. 20 (2010): 5506–14. http://dx.doi.org/10.1128/jb.00561-10.

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ABSTRACT Capsule polysaccharide (CPS) plays an important role in the virulence of Streptococcus pneumoniae and is usually used as the pneumococcal vaccine target. Glycerol-2-phosphate is found in the CPS of S. pneumoniae types 15A and 23F and is rarely found in the polysaccharides of other bacteria. The biosynthetic pathway of the nucleotide-activated form of glycerol-2-phosphate (NDP-2-glycerol) has never been identified. In this study, three genes (gtp1, gtp2, and gtp3) from S. pneumoniae 23F that have been proposed to be involved in the synthesis of NDP-2-glycerol were cloned and the enzyme products were expressed, purified, and assayed for their respective activities. Capillary electrophoresis was used to detect novel products from the enzyme-substrate reactions, and the structure of the product was elucidated using electrospray ionization mass spectrometry and nuclear magnetic resonance spectroscopy. Gtp1 was identified as a reductase that catalyzes the conversion of 1,3-dihydroxyacetone to glycerol, Gtp3 was identified as a glycerol-2-phosphotransferase that catalyzes the conversion of glycerol to glycerol-2-phosphate, and Gtp2 was identified as a cytidylyltransferase that transfers CTP to glycerol-2-phosphate to form CDP-2-glycerol as the final product. The kinetic parameters of Gtp1 and Gtp2 were characterized in depth, and the effects of temperature, pH, and cations on these two enzymes were analyzed. This is the first time that the biosynthetic pathway of CDP-2-glycerol has been identified biochemically; this pathway provides a method to enzymatically synthesize this compound.

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3

Camargo, Gustavo Schneider de. "Eu, Filósofo da Educação?" Filosofia e Educação 11, no. 2 (2019): 355–67. http://dx.doi.org/10.20396/rfe.v11i2.8656152.

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Ao enfrentar novos desafios de formação em uma subárea de estudo e pesquisa (Filosofia da Educação), busquei traçar a trajetória acadêmica daqueles autores/pesquisadores pertencentes à Filosofia da Educação. Minha trajetória acadêmica foi parâmetro para análise dos dados desta pesquisa. Coletei todos os trabalhos apresentados entre 2007 até 2017, das Reuniões Científicas Nacionais da Anped, GT17. Pesquisei a trajetória acadêmica dos autores destes trabalhos por meio do acesso ao currículo Lattes. Pude concluir que minha trajetória acadêmica não é tão errática como imaginava e que o estudo pode definir algumas premissas que podem ajudar a direcionar outros pesquisadores, envolvidos no tornarem-se filósofos da educação.

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4

Blennow, Kaj, Chun Chen, Claudia Cicognola, et al. "Cerebrospinal fluid tau fragment correlates with tau PET: a candidate biomarker for tangle pathology." Brain 143, no. 2 (2019): 650–60. http://dx.doi.org/10.1093/brain/awz346.

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Abstract To date, there is no validated fluid biomarker for tau pathology in Alzheimer’s disease, with contradictory results from studies evaluating the correlation between phosphorylated tau in CSF with tau PET imaging. Tau protein is subjected to proteolytic processing into fragments before being secreted to the CSF. A recent study suggested that tau cleavage after amino acid 368 by asparagine endopeptidase (AEP) is upregulated in Alzheimer’s disease. We used immunoprecipitation followed by mass spectrometric analyses to evaluate the presence of tau368 species in CSF. A novel Simoa® assay for quantification of tau368 in CSF was developed, while total tau (t-tau) was measured by ELISA and the presence of tau368 in tangles was evaluated using immunohistochemistry. The diagnostic utility of tau368 was first evaluated in a pilot study (Alzheimer’s disease = 20, control = 20), then in a second cohort where the IWG-2 biomarker criteria were applied (Alzheimer’s disease = 37, control = 45), and finally in a third cohort where the correlation with 18F-GTP1 tau PET was evaluated (Alzheimer’s disease = 38, control = 11). The tau368/t-tau ratio was significantly decreased in Alzheimer’s disease (P &lt; 0.001) in all cohorts. Immunohistochemical staining demonstrated that tau fragments ending at 368 are present in tangles. There was a strong negative correlation between the CSF tau368/t-tau ratio and 18F-GTP1 retention. Our data suggest that tau368 is a tangle-enriched fragment and that the CSF ratio tau368/t-tau reflects tangle pathology. This novel tau biomarker could be used to improve diagnosis of Alzheimer’s disease and to facilitate the development of drug candidates targeting tau pathology. Furthermore, future longitudinal studies will increase our understanding of tau pathophysiology in Alzheimer’s disease and other tauopathies.

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5

Teng, Edmond, Michael Ward, Paul T. Manser, et al. "Cross-sectional associations between [18F]GTP1 tau PET and cognition in Alzheimer's disease." Neurobiology of Aging 81 (September 2019): 138–45. http://dx.doi.org/10.1016/j.neurobiolaging.2019.05.026.

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6

Tourniaire, B., D. Annequin, F. Reiter, F. Lassauge, and C. Ricard. "GTS17 - Douleurs et handicaps chez l’enfant : évaluation de la douleur et du handicap. réponses thérapeutiques." Douleurs : Evaluation - Diagnostic - Traitement 6 (November 2005): 59–60. http://dx.doi.org/10.1016/s1624-5687(05)80347-6.

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7

White, Nicholas A., Kyle Clagg, Lauren E. Sirois, et al. "Practical Synthesis of a Stable Precursor for Positron Emission Tomography Imaging Agent 18F-GTP1." Organic Process Research & Development 24, no. 9 (2020): 1690–99. http://dx.doi.org/10.1021/acs.oprd.0c00301.

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8

Wolter, Ralf, Dorothea Richter, Eckhard Niegemann, and Martin Brendel. "Molecular characterisation of GTP1, a Saccharomyces cerevisiae gene encoding a small GTP-binding protein." Current Genetics 26, no. 5-6 (1994): 564–66. http://dx.doi.org/10.1007/bf00309951.

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9

Wout, P., K. Pu, S. M. Sullivan, et al. "The Escherichia coli GTPase CgtAE Cofractionates with the 50S Ribosomal Subunit and Interacts with SpoT, a ppGpp Synthetase/Hydrolase." Journal of Bacteriology 186, no. 16 (2004): 5249–57. http://dx.doi.org/10.1128/jb.186.16.5249-5257.2004.

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ABSTRACT CgtAE/ObgE/YhbZ is an Escherichia coli guanine nucleotide binding protein of the Obg/GTP1 subfamily whose members have been implicated in a number of cellular functions including GTP-GDP sensing, sporulation initiation, and translation. Here we describe a kinetic analysis of CgtAE with guanine nucleotides and show that its properties are similar to those of the Caulobacter crescentus homolog CgtAC. CgtAE binds both GTP and GDP with moderate affinity, shows high guanine nucleotide exchange rate constants for both nucleotides, and has a relatively low GTP hydrolysis rate. We show that CgtAE is associated predominantly with the 50S ribosomal subunit. Interestingly, CgtAE copurifies with SpoT, a ribosome-associated ppGpp hydrolase/synthetase involved in the stress response. The interaction between CgtAE and SpoT was confirmed by reciprocal coprecipitation experiments and by two-hybrid assays. These studies raise the possibility that the ribosome-associated CgtAE is involved in the SpoT-mediated stress response.

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10

Sanabria Bohórquez, Sandra, Jan Marik, Annie Ogasawara, et al. "[18F]GTP1 (Genentech Tau Probe 1), a radioligand for detecting neurofibrillary tangle tau pathology in Alzheimer’s disease." European Journal of Nuclear Medicine and Molecular Imaging 46, no. 10 (2019): 2077–89. http://dx.doi.org/10.1007/s00259-019-04399-0.

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Dissertations / Theses on the topic "GTP17"

1

Pope, M., R. Davis, and Adrian A. Evans. "Technological, Refitting and Microwear of the Stone Artefact Assemblage." SpoilHeap, 2020. http://hdl.handle.net/10454/17993.

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