Relevant bibliographies by topics / Guanidino pyrimidines

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Academic literature on the topic 'Guanidino pyrimidines'

Author: Grafiati
Published: 5 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "Guanidino pyrimidines"

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Durgadas, Mukherjee, and Nath Das Soumendra. "Design, synthesis and spectral characterization of chelates of PdII , PtII and RhIII with 6-guanidino-2,4-dimethyl-3,5-diazine and 6-phenyl guanidino-2,4-dimethyl3,5-diazine-potentialligands with biological interest." Journal of Indian Chemical Society Vol. 85, Jan 2008 (2008): 148–52. https://doi.org/10.5281/zenodo.5808696.

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Department of Chemistry, Mahadevananda Mahavidyalaya, Monirampur, Barrackpore, Kolkata-700 120, India <em>E-mail:</em> durgadas.mukherjee@gmail.com <em>Manuscript received 18 July 2007, revised 7 November 2007, accepted 19 November 2007</em> Complexes of 6-guanidino-2,4-dimethyl-3,5-diazine and 6-phenyl guanidino-2,4-dimethyl-3,5-diazine with Pd<sup>II</sup>, Pt<sup>II</sup> and Rh<sup>III</sup> have been reported. Complexes have been characterised on the basis of analytical, magnetic and spectral characterization and powder diffraction studies. Crystal field parameters have also been calculat
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2

Borrell, José I., Jordi Teixidó, Blanca Martínez-Teipel, et al. "An Unequivocal Synthesis of 4-Amino-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-2,7-diones and 2-Amino-3,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-4,7-diones." Collection of Czechoslovak Chemical Communications 61, no. 6 (1996): 901–9. http://dx.doi.org/10.1135/cccc19960901.

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An unequivocal set of procedures for the synthesis of 4-amino-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-2,7-diones (7) and 2-amino-3,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-4,7-diones (8), in a maximum of four steps from an α,β-unsaturated ester 1, is reported. Thus, the acid hydrolysis of the 2,4-diaminopyrido[2,3-d]pyrimidines 3 yields the 4-amino-2-oxopyrido[2,3-d]pyrimidines 7 while the cyclization of the Michael adducts 9 (formed by reaction of 1 and methyl cyanoacetate) with guanidine affords the corresponding 2-amino-4-oxopyrido[2,3-d]pyrimidines 8. Both isomers were also obtained by hy
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Verma, Vishal, Chandra Prakash Joshi, Alka Agarwal, Sakshi Soni, and Udichi Kataria. "A Review on Pharmacological Aspects of Pyrimidine Derivatives." Journal of Drug Delivery and Therapeutics 10, no. 5 (2020): 358–61. http://dx.doi.org/10.22270/jddt.v10i5.4295.

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Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has the nitrogens at positions 1 and 3 in the ring. Pyrimidines are typically synthesized by the “Principal Synthesis” involving cyclization of beta-dicarbonyl compounds with N-C-N compounds. Reaction of the former with amidines to give 2-substituted pyrimidines, with urea to give 2-pyrimidiones, and guanidines to give 2-aminopyrimidines are typical. Pyrimidines can be prepared via the biginelli reaction. Many other methods
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R., S. Dhivare, and S. Rajput S. "Microwave Assisted Synthesis and Microbial Screening of Novel Amino-pyrimidine Derivatives using Bis-chalcones." Journal of Chemistry and Chemical Sciences (An International Research Journal), www.chemistry-journal.org 5, no. 10 (2015): 550–56. https://doi.org/10.5281/zenodo.3909691.

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ABSTRACT A simple and clean one pot method for the preparation of amino-pyrimidine derivatives using chalcones of cyclic imides and guanidine nitrate in presence of neutral alumina under microwave supported solvent free condition is described. Some of the synthesized amino-pyrimidines showed synergistic significant activities against Candida albicans and Aspergillus niger fungal strains.
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R., PRASAD REDDY, RAVINDRANATH A., SUDHAKAR B., SUNDARA RAMAIAH T., and VENKATESHWER RAO M. "Azatriterpenes. Part-VIII. Synthesis of Ring-A Fused Pyrimidines of Pentacyclic Triterpenes." Journal of Indian Chemical Society Vol. 65, Oct 1988 (1988): 688–90. https://doi.org/10.5281/zenodo.6076530.

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Department of Chemistry, Nizam College (Osmania University), Hyderabad-500 001 <em>&nbsp;Manuscript received 5 April 1988, accepted 27 July 1988</em> Condensation of urea, guanidine and thiourea with 2-formyl (hydroxymethylene) derivatives of methyl oleanonate (1), 11-oxomethyl oleanonate (2) and methyl betulonate (3) furnished their respective [3,2-d]pyrimidine-2&#39;-ones (4 -6), 2&#39;-imino-[3,2-d]pyrimidines (7-9) and 2&#39;-mercapto [3,2-<em>d</em>]pyrimidines (10 -12). The compounds were characterised by their elemental and spectral data.
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R., S. Dhivare, and S. Rajput S. "Microwave assisted synthesis and antimicrobial screening of novel 9-(N-phenyl) - 4, 5-(2″, ‴- methoxyphenol)-9H-1,3,6,8,9-hexa-azo-fluorene-2,7- diamine derivatives using bis-heterocyclic chalcones." INTERNATIONAL JOURNAL OF ADVANCES IN PHARMACY, BIOLOGY AND CHEMISTRY 4, no. 4 (2015): 863–70. https://doi.org/10.5281/zenodo.3909811.

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<strong>ABSTRACT</strong> Amino-pyrimidine derivatives were synthesized by a simple and clean single pot method using bis-chalcones of different substituted phenyl glutarimides and guanidine nitrate with neutral alumina irradiated under the microwave supported solvent less condition is demonstrated. All the compounds were screened for their antimicrobial activities and showed moderate activities. But certain amino-pyrimidines exhibited synergistic and significant activities against <em>Candida albicans</em> and <em>Aspergillus niger</em> fungal genres.
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Priyadarsini, P., V. Madhava Rao, and C. Venkata Rao. "Synthesis, Characterization and Anti-inflammatory Activity of New Pyrimidines." Asian Journal of Organic & Medicinal Chemistry 4, no. 1 (2019): 46–50. http://dx.doi.org/10.14233/ajomc.2019.ajomc-p178.

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The synthesis of some pyrimidine derivatives was achieved by conden-sation of 2-hydroxyacetophenone and cinnamic acid as starting materials through 1,3-diketones as intermediates. The resulting diketones have been converted into substituted pyrimidines by reaction with urea, thiourea and guanidine in the presence of trace of triethylamine and pyridine in calculated quantity. The synthesized compounds were characterized by their physical properties, NMR and LC-mass spectroscopic studies and also screened for their anti-inflammatory activity.
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Bannunah, Azzah M., Naeem Fqusty, Bayan Tayeb Bokhari, Saad Alghamdi, Waheeb Alharbi, and Mohammad Asif. "Synthesis and in vitro antihyperglycemic evaluation of some new 3-(4-ethyl-6-methyl pyrimidin-2-yl)-2-arylthiazolidin-4-one derivatives." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 35, no. 01 (2025): 85. https://doi.org/10.59467/ijhc.2025.35.85.

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Due to the pharmacological potential of thiazolidinedione derivatives as antidiabetic drugs, six pyrimidine hybrids of aryl thiazolidin-4-ones (2a-f) were synthesized in two steps. In the first step, 4-ethyl-6-methyl-pyrimidin-2-amine (1) was synthesized by reacting 1,3-hexane-2,4-dione with guanidine. Compound 1 reacted with appropriate aryl aldehyde and mercaptoacetic acid to form compounds 2a-f. All the compounds (2a-f) exhibited varying degrees of a-amylase inhibitory activity, particularly compounds 2b (IC50 = 25 μg/mL), 2f (IC50 = 30 μg/mL), 2a and 2c (IC50 = 35 μg/mL) exhibited consider
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El-Sawy, Eslam, Adel Mandour, Khaled Mahmoud, Inas Islam, and Heba Abo-Salem. "Synthesis, antimicrobial and anti-cancer activities of some new N-ethyl, N-benzyl and N-benzoyl-3-indolyl heterocycles." Acta Pharmaceutica 62, no. 2 (2012): 157–79. http://dx.doi.org/10.2478/v10007-012-0020-3.

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Synthesis, antimicrobial and anti-cancer activities of some newN-ethyl,N-benzyl andN-benzoyl-3-indolyl heterocyclesA series of 1-(N-substituted-1H-indol-3-yl)-3-arylprop-2-ene-1-ones (2a, b-4a, b) were prepared and allowed to react with urea, thiourea or guanidine to give pyrimidine derivatives5a, b-13a, b. Reaction of2a, b-4a, bwith ethyl acetoacetate in the presence of a base gave cyclohexanone derivatives14a, b-16a, b. Reaction of the latter compounds with hydrazine hydrate afforded indazole derivatives17a, b-19a, b. On the other hand, reaction of2a, b-4a, bwith some hydrazine derivatives,
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Jyothi, K., and M. Kannadasan. "Novel Pyrimidine Tethered Benzamide Derivatives as Potential Anticancer Agents: Synthesis, Characterization, Molecular Docking and In vitro Cytotoxicity Evaluation." Asian Journal of Chemistry 36, no. 12 (2024): 2870–78. https://doi.org/10.14233/ajchem.2024.32688.

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Current research work presents the synthesis, characterization, molecular docking study and in vitro cytotoxicity evaluation of novel pyrimidine-tethered benzamide derivatives as potential anticancer agents. The synthesis involved multi-steps procedure, including the synthesis of various chalcones (3a-t) with corresponding ketones (1 and 2) and substituted aldehydes (a-j), followed by pyrimidine amines (5a-t) with condensation of chalcones and guanidine and finally pyrimidinyl benzamide derivatives (8a-t) from compounds 5a-t coupling with acid chloride (7) using DIBAL-H. Synthesized compounds
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Dissertations / Theses on the topic "Guanidino pyrimidines"

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Berzosa, Rodríguez Xavier. "Diseño y síntesis de una quimioteca de sistemas 5,6-dihidropirido[2,3-d]pirimidin-7(8H)-ona no sustituidos en C4 como inhibidores potenciales de tirosina quinasas." Doctoral thesis, Universitat Ramon Llull, 2010. http://hdl.handle.net/10803/9299.

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Les Tirosina Cinases (TKs) són un grup de Proteïna Cinases claus en la senyalització cel·lular. Aquestes Cinases estan implicades, entre d'altres, en processos de creixement tumoral, fet que fa que la recerca d'inhibidors de TKs sigui una àrea d'investigació molt important en química mèdica.<br/>En aquest context es desenvolupa el present treball en el qual es pretenen sintetitzar inhibidors potencials de Tirosina Cinases amb estructura 4-hidrogenpirido[2,3-d]pirimidínica. Molècules amb aquesta estructura han presentat elevada activitat com inhibidors de TKs pel que en primer lloc s'aborda la
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Book chapters on the topic "Guanidino pyrimidines"

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Robin, Yvonne, and Yvonne Guillou. "Phascoline and Phascolosomine:New Catabolic Products of Pyrimidines in Sipunculid Worms." In Guanidines 2. Springer US, 1989. http://dx.doi.org/10.1007/978-1-4613-0821-8_4.

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"Purines and Pyrimidines: Essential Nitrogen Heterocycles." In The Chemical Biology of Carbon. The Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/bk9781839169502-00205.

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This is the first of three chapters on biologic heterocycles as central chemical and metabolic building blocks. This chapter focuses specifically on the pyrimidine and purine building blocks for RNA and DNA. The four functional groups of amides, amidines, ureas, and guanidines dictate the hydrogen bonding rules for Watson–Crick base pairing in double helical DNA. The biosynthetic logic for both the monocyclic pyrimidine nucleotides, uridine monophosphate and cytidine triphosphate, and the bicyclic purines, adenosine monophosphate, and guanosine monophosphate, are evaluated based on simple meta
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You might also be interested in the extended bibliographies on the topic 'Guanidino pyrimidines' for particular source types:
Journal articles
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