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Journal articles on the topic 'Guideline-Directed Therapy'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Walsh, Mary Norine. "Guideline-Directed Medical Therapy." Journal of the American College of Cardiology 80, no. 16 (2022): 1542–44. http://dx.doi.org/10.1016/j.jacc.2022.08.739.

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2

O’Connor, Christopher M. "Guideline-Directed Medical Therapy Clinics." JACC: Heart Failure 7, no. 5 (2019): 442–43. http://dx.doi.org/10.1016/j.jchf.2019.04.001.

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3

Hess, Connie N., and Marc P. Bonaca. "Guideline-Directed Medical Therapy in PAD." JACC: Cardiovascular Interventions 16, no. 3 (2023): 344–46. http://dx.doi.org/10.1016/j.jcin.2022.10.015.

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4

Sandhu, Alexander T., and Paul A. Heidenreich. "The Affordability of Guideline-Directed Medical Therapy." Circulation 143, no. 11 (2021): 1073–75. http://dx.doi.org/10.1161/circulationaha.120.053291.

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5

Bell, Alan, and Nicholas Giacomantonio. "Guideline-Directed Medical Therapy—Secondary Prevention Checklist." Canadian Journal of Cardiology 40, no. 8 (2024): S53—S56. http://dx.doi.org/10.1016/j.cjca.2024.05.019.

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6

Leyva, Francisco, Carsten W. Israel, and Jagmeet Singh. "Declining Risk of Sudden Cardiac Death in Heart Failure: Fact or Myth?" Circulation 147, no. 9 (2023): 759–67. http://dx.doi.org/10.1161/circulationaha.122.062159.

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The notion that the risk of sudden cardiac death (SCD) in patients with heart failure (HF) is declining seems to be gaining traction. Numerous editorials and commentaries have suggested that SCD, specifically arrhythmic SCD, is no longer a significant risk for patients with HF on guideline-directed medical therapy. In this review, we question whether the risk of SCD has indeed declined in HF trials and in the real world. We also explore whether, despite relative risk reductions, the residual SCD risk after guideline-directed medical therapy still suggests a need for implantable cardioverter de

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7

Khosravi, Zahra, Muneeb Iqbal, and Sam Kant. "Finerenone: Completing the Cardiorenal Guideline-Directed Medical Therapy?" Kidney News 17, no. 1 (2025): 14. https://doi.org/10.62716/kn.000332024.

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Mack, Michael, and Paul Grayburn. "Guideline-Directed Medical Therapy for Secondary Mitral Regurgitation." JACC: Heart Failure 5, no. 9 (2017): 660–62. http://dx.doi.org/10.1016/j.jchf.2017.07.007.

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9

Patolia, Harsh, Muhammad Shahzeb Khan, Gregg C. Fonarow, Javed Butler, and Stephen J. Greene. "Implementing Guideline-Directed Medical Therapy for Heart Failure." Journal of the American College of Cardiology 82, no. 6 (2023): 529–43. http://dx.doi.org/10.1016/j.jacc.2023.03.430.

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10

Crea, Filippo. "Heart failure: how to optimize guideline-directed medical therapy." European Heart Journal 43, no. 27 (2022): 2533–37. http://dx.doi.org/10.1093/eurheartj/ehac356.

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11

Khan, Muhammad Shahzeb, Matthew W. Segar, Muhammad Shariq Usman, et al. "Frailty, Guideline-Directed Medical Therapy, and Outcomes in HFrEF." JACC: Heart Failure 10, no. 4 (2022): 266–75. http://dx.doi.org/10.1016/j.jchf.2021.12.004.

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12

Davidson, Beth Towery, and Terri Lynn Allison. "Improving heart failure patient outcomes utilizing guideline-directed therapy." Nurse Practitioner 42 (July 2017): 3–14. http://dx.doi.org/10.1097/01.npr.0000520610.88962.03.

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13

Davidson, Beth Towery, and Terri Lynn Allison. "Improving heart failure patient outcomes utilizing guideline-directed therapy." Nurse Practitioner 42 (July 2017): 2. http://dx.doi.org/10.1097/01.npr.0000521666.42697.6c.

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14

Banerji, Sourin, and Mohammad Farooq. "Impacting Guideline Directed Medical Therapy Optimization With Story Health." Journal of Cardiac Failure 29, no. 4 (2023): 662–63. http://dx.doi.org/10.1016/j.cardfail.2022.10.285.

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15

Rao, Suman, Akhila Sunkara, Ashwini Ashwath, Nimisha Srivastava, and Emily Albert. "Lupus Cerebritis Refractory to Guideline-Directed Therapy: A Case Report." Journal of Investigative Medicine High Impact Case Reports 9 (January 2021): 232470962110087. http://dx.doi.org/10.1177/23247096211008708.

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Systemic lupus erythematosus is an autoimmune disease that affects multiple organs and organ systems, subsequently requiring an elaborate regimen for management. We present the case of a 63-year-old female who developed unrelenting symptoms of drug-induced lupus, which persisted even after the offending agent was withdrawn, unmasking her underlying systemic lupus erythematosus. She continued to develop neuropsychiatric symptoms, including mania and hallucinations, which complicated the management of her disease. After exhausting the bank of anti-inflammatory and immunomodulators recommended by

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16

Sia, H. P., P. F. Chong, E. L. S. Lim, et al. "Guideline-directed medical therapy in HFrEF: Are we doing enough?" International Journal of Cardiology 417 (December 2024): 132850. https://doi.org/10.1016/j.ijcard.2024.132850.

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17

Baksh, Gladys, Michele Haydo, Suzanne Frazier, et al. "Improving Utilization of Guideline-Directed Medical Therapy for Heart Failure." Journal for Nurse Practitioners 20, no. 8 (2024): 105108. http://dx.doi.org/10.1016/j.nurpra.2024.105108.

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18

Sinner, Gregory, You W. Lin, Samy-Claude Elayi, and Maya Guglin. "GUIDELINE-DIRECTED MEDICAL THERAPY BEFORE CRT: IS IT ALWAYS NECESSARY?" Journal of the American College of Cardiology 69, no. 11 (2017): 814. http://dx.doi.org/10.1016/s0735-1097(17)34203-1.

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19

Fonarow, Gregg C., and Stephen J. Greene. "Rapid and Intensive Guideline-Directed Medical Therapy for Heart Failure." Journal of the American College of Cardiology 81, no. 22 (2023): 2145–48. http://dx.doi.org/10.1016/j.jacc.2023.04.006.

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20

Cooper, Lauren B., and Lee H. Schwamm. "Winning the Battle of Timely Guideline-Directed Medical Therapy Titration." JACC: Heart Failure 12, no. 4 (2024): 691–92. http://dx.doi.org/10.1016/j.jchf.2024.02.007.

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21

Maron, David J., Jonathan D. Newman, Rebecca Anthopolos, et al. "Guideline-Directed Medical Therapy and Outcomes in the ISCHEMIA Trial." Journal of the American College of Cardiology 85, no. 12 (2025): 1317–31. https://doi.org/10.1016/j.jacc.2025.01.028.

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22

O'Hara, Marianne, Amanda Smith, Emma Foster, and Stephen J. Leslie. "A heart failure care optimisation project in the north of Scotland." British Journal of Cardiac Nursing 15, no. 9 (2020): 1–9. http://dx.doi.org/10.12968/bjca.2020.0042.

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Introduction: This project aimed to assess and optimise the treatment of all patients with heart failure with reduced ejection fraction (HFrEF). Methods: Consecutive patients discharged with a heart failure code (ICD-10) between April 2014 and July 2017 were included. The medical records were reviewed to ensure optimal medical therapy and in cases where this was not being received, a process of ‘active optimisation’ was initiated. Results: Out of 656 patients, 139 were identified as eligible for guideline-directed treatment, 129 (93%) of which were receiving optimal medical therapy. Of these,

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23

Milani, Juliana Goulart Prata Oliveira, Mauricio Milani, Graziella França Bernardelli Cipriano, Dominique Hansen, and Gerson Cipriano Junior. "Exercise intensity domains determined by heart rate at the ventilatory thresholds in patients with cardiovascular disease: new insights and comparisons to cardiovascular rehabilitation prescription recommendations." BMJ Open Sport & Exercise Medicine 9, no. 3 (2023): e001601. http://dx.doi.org/10.1136/bmjsem-2023-001601.

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ObjectivesTo compare the elicited exercise responses at ventilatory thresholds (VTs: VT1 and VT2) identified by cardiopulmonary exercise testing (CPET) in patients with cardiovascular disease (CVD) with the guideline-directed exercise intensity domains; to propose equations to predict heart rate (HR) at VTs; and to compare the accuracy of prescription methods.MethodsA cross-sectional study was performed with 972 maximal treadmill CPET on patients with CVD. First, VTs were identified and compared with guideline-directed exercise intensity domains. Second, multivariate linear regression analyses

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24

Ullah, Asif, Javaid ur Rehman, Muhammad Aslam, Amjad Mustafa, Ali Asad, and Fahad Naim. "St Segment Resolution in Patients given Streptokinase Injection along with Guideline directed Medical Therapy." Pakistan Journal of Medical and Health Sciences 15, no. 8 (2021): 2553–55. http://dx.doi.org/10.53350/pjmhs211582553.

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Objective: To determine the ST resolution in patients given streptokinase along with guideline medical therapy Methodology: This descriptive cross sectional study was carried out in department of Cardiology DHQTH KDA Kohat on 109 patients after obtaining informed consent from the patients. Patients were given guideline directed medical therapy & streptokinase for ST elevation MI. The ST-segment elevation resolution was calculated after 90 minutes of treatment with streptokinase, and stratified as complete ST segment resolution (> 70% ST-resolution), partial resolution (30-70% ST-resolut

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25

Sundström, Johan, Anna Norhammar, Stelios Karayiannides, et al. "Are there lost opportunities in chronic kidney disease? A region-wide cohort study." BMJ Open 14, no. 4 (2024): e074064. http://dx.doi.org/10.1136/bmjopen-2023-074064.

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ObjectivesIdentify the windows of opportunity for the diagnosis of chronic kidney disease (CKD) and the prevention of its adverse outcomes and quantify the potential population gains of such prevention.Design and settingObservational, population-wide study of residents in the Stockholm and Skåne regions of Sweden between 1 January 2015 and 31 December 2020.ParticipantsAll patients who did not yet have a diagnosis of CKD in healthcare but had CKD according to laboratory measurements of CKD biomarkers available in electronic health records.Outcome measuresWe assessed the proportions of the patie

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26

Romero, Erick, Stella Yala, Mohammad Soroya, et al. "Titration Clinic Assisted By Telemonitoring For Guideline Directed Medical Therapy Optimization." Journal of Cardiac Failure 28, no. 5 (2022): S48. http://dx.doi.org/10.1016/j.cardfail.2022.03.126.

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27

Gilstrap, Lauren Gray, Christopher Leggett, James O’Malley, Amber Barnato, Anna N. A. Tosteson, and Jonathan Skinner. "URBAN VS. RURAL GUIDELINE DIRECTED MEDICAL THERAPY USE AFTER HFREF HOSPITALIZATION." Journal of the American College of Cardiology 79, no. 9 (2022): 345. http://dx.doi.org/10.1016/s0735-1097(22)01336-5.

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28

Cassagnol, Manouchkathe, Ofek Hai, Shaqeel A. Sherali, et al. "Impact of cardiologist intervention on guideline-directed use of statin therapy." World Journal of Cardiology 12, no. 8 (2020): 419–26. http://dx.doi.org/10.4330/wjc.v12.i8.419.

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29

Pogge, Elizabeth, and Stephanie Sibicky. "Heart Failure in Older People Part 2: Guideline-Directed Medical Therapy." Senior Care Pharmacist 39, no. 10 (2024): 360–72. http://dx.doi.org/10.4140/tcp.n.2024.360.

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Heart failure is a common cardiovascular disease that affects older people and has a high rate of mortality. Treatment for heart failure has evolved in the past 10 years to include novel evidence-based agents as well as changes in how medications are initiated and up-titrated. Despite evidence of the importance of using four guideline-directed medications, older people are often undertreated with these lifesaving therapies. Senior care pharmacists play an important role in heart failure management among older people by providing therapeutic recommendations; monitoring therapeutic interventions

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30

Tromp, J., W. Ouwerkerk, B. G. Demissei, et al. "Novel endotypes in heart failure: effects on guideline-directed medical therapy." European Heart Journal 39, no. 48 (2018): 4269–76. http://dx.doi.org/10.1093/eurheartj/ehy712.

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31

Fonarow, Gregg C., and Boback Ziaeian. "Gaps in Adherence to Guideline-Directed Medical Therapy Before Defibrillator Implantation ∗." Journal of the American College of Cardiology 67, no. 9 (2016): 1070–73. http://dx.doi.org/10.1016/j.jacc.2015.12.045.

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32

Pinho-Gomes, Ana-Catarina, Luis Azevedo, Jung-Min Ahn, et al. "Compliance With Guideline-Directed Medical Therapy in Contemporary Coronary Revascularization Trials." Journal of the American College of Cardiology 71, no. 6 (2018): 591–602. http://dx.doi.org/10.1016/j.jacc.2017.11.068.

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33

Thibodeau, Jennifer T., and Eiran Z. Gorodeski. "Telehealth for Uptitration of Guideline-Directed Medical Therapy in Heart Failure." Circulation 142, no. 16 (2020): 1507–9. http://dx.doi.org/10.1161/circulationaha.120.050582.

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34

Balakumaran, Kathir, Joseph Ingrassia, Aadhar Patil, and Richard Soucier. "The Impact of a Nurse Led Guideline Directed Medical Therapy Clinic." Journal of Cardiac Failure 24, no. 8 (2018): S72. http://dx.doi.org/10.1016/j.cardfail.2018.07.301.

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35

Ezekowitz, Justin, Ciaran McMullan, Cynthia Westerhout, et al. "Effect of Vericiguat in Victoria According to Guideline-directed Medical Therapy." Journal of Cardiac Failure 26, no. 10 (2020): S65—S66. http://dx.doi.org/10.1016/j.cardfail.2020.09.193.

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36

Ezekowitz, Justin, Ciaran McMullan, Cynthia Westerhout, et al. "Effect Of Vericiguat In Victoria According To Guideline-directed Medical Therapy." Journal of Cardiac Failure 26, no. 12 (2020): 1108–9. http://dx.doi.org/10.1016/j.cardfail.2020.11.017.

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37

Margolin, Emily A., Trina Huynh, Alison Brann, and Barry Greenberg. "Determinants Of Guideline Directed Medical Therapy Implementation During Heart Failure Hospitalization." Journal of Cardiac Failure 30, no. 1 (2024): 276. http://dx.doi.org/10.1016/j.cardfail.2023.10.377.

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38

Khan, Muhammad Shahzeb, Stephen J. Greene, and Adam D. DeVore. "Serial NT-proBNP Measurements and Implementation of Guideline-Directed Medical Therapy." JACC: Heart Failure 12, no. 3 (2024): 488–91. http://dx.doi.org/10.1016/j.jchf.2024.01.003.

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39

BANDO, Hiroshi. "Latest Standard Management for Heart Failure with Guideline-Directed Medical Therapy (GDMT)." Journal of Health Care and Research 3, no. 2 (2022): 35–40. http://dx.doi.org/10.36502/2022/hcr.6209.

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Sodium–glucose cotransporter 2 inhibitor (SGLT2i) has been attracting attention for novel agent for patients with diabetes and also heart failure (HF), in which the left ventricular ejection fraction (LVEF) has decreased. For standard cardiovascular treatment, 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure is recently presented. Some important perspectives were found, which are HF with mildly reduced EF (HFmrEF), HF with improved EF (HFimpEF) and HF with preserved EF (HFpEF). For patients with HFmrEF, SGLT2i can contribute reducing HF hospitalizations and cardiovascular death.

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40

Leena C L, R Sreekanth Reddy, G. Nirmala, O. Nishitha, and D. Maryline Flinsi. "A study to assess the knowledge and expected outcome on guidelines directed to medical therapy in heart failure patient undergoing treatment in IP and OP basis at Apollo DRDO hospitals, Hyderabad." International Journal of Science and Research Archive 15, no. 2 (2025): 472–79. https://doi.org/10.30574/ijsra.2025.15.2.1339.

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Heart failure is a complex clinical condition. Optimal use of guideline-directed medical therapy (GDMT) can prevent hospitalization and mortality among patients with heart failure (HF). Although the guidelines-directed medical therapy for heart failure patients may incur slightly higher expenses, our primary concern was ensuring patients' adherence to this therapy. By conducting this research, we aimed to determine whether adherence to these guidelines would lead to improved patient outcomes and decreased mortality. The study conducted at Apollo DRDO Hospital in Hyderabad selected 60 patients

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41

Benson, Ruth A., Kelvin Okoth, Deepiksana Keerthy, et al. "Analysis of the relationship between sex and prescriptions for guideline-recommended therapy in peripheral arterial disease, in relation to 1-year all-cause mortality: a primary care cohort study." BMJ Open 12, no. 3 (2022): e055952. http://dx.doi.org/10.1136/bmjopen-2021-055952.

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ObjectivesTo explore population patterns of sex-based incidence and prevalence of peripheral arterial disease (PAD), guideline-directed best medical therapy prescriptions and its relationship with all-cause mortality at 1 year.DesignA retrospective cohort study.SettingAnonymised electronic primary care from 787 practices in the UK, or approximately 6.2% of the UK population.ParticipantsAll registered patients over 40 with a documented diagnosis of peripheral arterial disease.Outcome measurePopulation incidence and prevalence of PAD by sex. Patterns of guideline-directed therapy, and correlatio

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42

Fonarow, Gregg C. "Get with The Guidelines and Guideline Directed Medical Therapy: Why it Matters." Journal of Cardiac Failure 28 (2022): 4. http://dx.doi.org/10.1016/j.cardfail.2022.07.007.

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43

van Hout, G. P. J., and M. G. van der Meer. "The real-life heart failure patient: importance of guideline-directed medical therapy." Netherlands Heart Journal 29, no. 7-8 (2021): 368–69. http://dx.doi.org/10.1007/s12471-021-01596-1.

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44

Piccini, Jonathan P., Haolin Xu, Margueritte Cox, et al. "Adherence to Guideline-Directed Stroke Prevention Therapy for Atrial Fibrillation Is Achievable." Circulation 139, no. 12 (2019): 1497–506. http://dx.doi.org/10.1161/circulationaha.118.035909.

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45

Shah, Rahman. "Optimal Guideline-Directed Medical Therapy for Patients With Stable Ischemic Heart Disease." Journal of the American College of Cardiology 71, no. 24 (2018): 2861–62. http://dx.doi.org/10.1016/j.jacc.2018.03.528.

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46

Goyal, Parag. "Do We Need Shared Decision Making When Prescribing Guideline-Directed Medical Therapy?" Journal of Cardiac Failure 25, no. 9 (2019): 701–2. http://dx.doi.org/10.1016/j.cardfail.2019.08.016.

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47

Ilonze, Onyedika J., Daniel E. Forman, Lisa LeMond, et al. "Beyond Guideline-Directed Medical Therapy." JACC: Heart Failure, October 2024. http://dx.doi.org/10.1016/j.jchf.2024.08.018.

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48

Jolobe, Oscar M. P. "Tolerance of Guideline-Directed Medical Therapy." JAMA Internal Medicine, March 31, 2025. https://doi.org/10.1001/jamainternmed.2025.0027.

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49

Zeitler, Evan M., and Amy K. Mottl. "Toward Guideline-Directed Medical Therapy in Nephrology." Clinical Journal of the American Society of Nephrology, November 22, 2022, CJN.12401022. http://dx.doi.org/10.2215/cjn.12401022.

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50

Ambardekar, Amrut V., and Abdelghani El Rafei. "Guideline-Directed Medical Therapy in Heart Failure." JACC: Heart Failure, March 2023. http://dx.doi.org/10.1016/j.jchf.2023.01.005.

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