Dissertations / Theses: 'Guillard'

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Guillard, Nicolas [Verfasser], and Andreas [Akademischer Betreuer] Burkert. "Growth and fuelling of galactic nuclei / Nicolas Guillard ; Betreuer: Andreas Burkert." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2018. http://d-nb.info/1160876134/34.

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Jimenes, Rémi. "Charlotte Guillard au Soleil d'Or (ca. 1507-1557) : Une carrière typographique." Thesis, Tours, 2014. http://www.theses.fr/2014TOUR2011.

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Successivement veuve de Berthold Rembolt et de Claude Chevallon, Charlotte Guillard hérite en 1537 du plus ancien atelier typographique français, le Soleil d'Or, dont elle conduit l'activité durant près de vingt années. Sous sa direction, l'atelier parvient à accaparer deux marchés spécifiques : textes de droit savant et ouvrages des Pères de l'Église. La thèse vise à interroger les conditions de réalisation de ce programme éditorial. On y présente les modalités matérielles de production et de commercialisation des ouvrages. On met ainsi en évidence la forte implication de la parentèle de Charlotte Guillard à tous les niveaux de la chaîne éditoriale, et la coexistence de réseaux de collaborateurs qui, en dépit de motivations intellectuelles et idéologiques parfois divergentes, parviennent à faire œuvre commune. À travers une enquête mobilisant à la fois les sources archivistiques, l'analyse matérielle des ouvrages imprimés et la lecture des préfaces et épîtres liminaires, la monographie permet d'écrire une histoire concrète de l'activité intellectuelle qui tienne compte des conditions idéologiques, sociales et économiques de sa mise en œuvre
Widow of Berthold Rembolt first, then of Claude Chevallon, Charlotte Guillard became in 1537 heiress of France's oldest typography workshop. With Charlotte Guillard at its head, the Soleil d'Or managed to monopolise two specific markets, the law texts and the works of the Church Fathers. The purpose of our thesis is to investigate the practical conditions which made these publications possible. It will highlight the material arrangements of the production and selling of those books, and focus at the people who stayed at Charlotte Guillard's side. This will allow us to demonstrate the importance of her relatives at every step of the process, and to show the coexistence of various networks of collaborators who manage to work on a common basis despite, at times, opposite intellectual and ideological motivations. Calling on manuscript archives, physical bibliography, and an analysis of the prefaces and liminary epistles, this monograph allows us to write a holistic history of the intellectual endeavour, taking into account all the ideological, social and economic conditions entering in its construction

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Mercado, Tupiño Estefanía. "Cultivo de la microalga Scenedesmus Obliquus var. Dimorphus (TURPIN) para la obtención de biomasa y lípidos." Bachelor's thesis, Universidad Ricardo Palma, 2016. http://cybertesis.urp.edu.pe/handle/urp/1095.

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Las microalgas han demostrado ser la fuente de energía más económica. Además, reduce el dióxido de carbono, también tienen una mayor producción en un corto tiempo y menor espacio a diferencia de otros cultivos. Entre las más de 100 especies de microalgas, el Scenedesmus dimorphus es el que tiene mayor potencial. El objetivo de este trabajo de tesis fue determinar de qué manera con un medio de cultivo para Scenedesmus obliquus var. dimorphus (Turpin) se obtiene cantidad de biomasa y contenido de aceite. Inicialmente, el trabajo experimental consistió en la obtención de la cepa pura de Scenedesmus dimorphus (14 mL). Seguidamente, se realizó el escalamiento de cultivo desarrollándose de la siguiente manera: 100 mL, 250 mL, 500 mL, 1L, 2L y 5L, con el fin de determinar las curvas de crecimiento mediante el conteo celular de S. dimorphus con el uso de la cámara de Neubauer, obteniendo los siguientes resultados: 3’ 451,500 unidades celulares en 120 horas (Bayfolan Forte), 2’ 472,500 unidades celulares en 192 horas (BG-11) y 327,500 unidades celulares en 96 horas (Guillard). Concluyendo que el Bayfolan Forte se obtuvo un mejor resultado. A continuación, se realizó 5 cosechas, luego se usó el método de floculación mediante la utilización del sulfato de aluminio Al2(SO4)3 y posteriormente, para la extracción de aceites, se molió la biomasa seca (36.5 g) seguido por la extracción con disolvente en hexano/ isopropanol, y se obtuvo un total de 30 mL de lípidos. Finalmente, en la parte estadística se comprobó la validez de las hipótesis utilizando diferentes métodos, tales como: Anova, Tukey y T. Student.

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4

Koullapi, Christina. "Le modèle dramaturgique de la Grèce antique dans la tragédie lyrique des Lumières : regards sur la tragédie-opéra de Gluck à la Révolution (1774-1789)." Thesis, Lyon 2, 2015. http://www.theses.fr/2015LYO20064.

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La tragédie-opéra de Christoph-Willibald Gluck réalise les aspirations esthétiques des philosophes des Lumières dont l’influence de l’esthétique de la sensibilité, et la quête des origines en constituent la matrice poétique. Derrière les nouveautés introduites par la tragédie lyrique réformée dans les rapports qu’entretient le texte poétique à l’élément musical, s’émancipe un objet lyrique global qui, se fondant sur la construction organique de la tragédie grecque, s’érige en modèle poétique unitif. Souhaitant se placer au service d’une pluridisciplinarité exigée par les affinités qui s’établissent entre la tragédie grecque et le drame lyrique dès son origine, la présente contribution académique vise à apporter des éclaircissements sur le rôle du modèle antique dans l’élaboration théorique et la réalisation scénique de la tragédie-opéra pré-révolutionnaire de 1774 à 1789. Alors que le recours à la tragédie grecque répond à la fois aux nouvelles idées philosophiques et à la poétique globalisante de l’œuvre lyrique réformée, des inspirations textuelles et des liens de l’ordre de la construction formelle et poétique, notamment dans la réalisation des tableaux dramatiques, revendiquent une parenté composite et immédiate. Le lien intrinsèque établi dorénavant entre le théâtre déclamé antique et le théâtre lyrique réforme, met en lumière des questions inédites ou provenant du passé sur le rôle de la musique, aussi bien dans son rapport avec le poème que dans la corrélation avec le modèle global, faisant, ainsi ressortir le concept de musique « dramatique » sous fond de querelle musicale. Le recours à la tragédie grecque, derrière une apparence de légitimation du nouveau drame lyrique, fait apparaître l’émancipation de la forme antique, dont est reproduite surtout la finalité poétique. Entre le parcours d’un compositeur-dramaturge qui s’achève avec la tragédie d’Iphigénie en Tauride (1779) et celui d’un librettiste dont les poèmes ultérieurs s’inspirent de la forme antique, la tragédie-opéra, fondée sur une conception de théâtre « éprouvé », trouve pleinement sa place dans le mouvement du néo-classicisme des Lumières
Christophe-Willibald Gluck’s tragédie-opéra, accomplishes the aesthetic inspirations of the Enlightenment based on the new aesthetic of sensibility and the quest of origins, its federal matric elements. Behind novelties introduced by the new relation between text and music, the emancipation of a global lyric project is founded in the organic structure of Greek tragedy, becoming, therefore, a poetic and unity model. The present academic contribution, based on a bi-disciplinary exigency due to early affinities between ancient Greek tragedy and opera, comes to enlighten the role of ancient model played on the tragédie-opéra’s theoretical elaboration and stage performance from 1774 to 1779. Although ancient tragedy responds not only to new ideas introduced by the Enlightenment but to the poetics of reformed opera, textual, formal and poetic inspirations, up to generating dramatic tableaux, mark a composite and immediate affiliation. New relation between ancient dramatic and lyric theatre is established on two fundamental directions: music’s new role as a poems interpreter, a collaborator to global result and as an art claiming its autonomy. On the other hand, the references to Greek tragedy to legitimize the reformed opera, reveals the emancipation of ancient Greek tragedy. The parallel itinerary of a composer-dramatist and a librettist, finishing, for the first, and, starting, for the second, with Iphigénie en Tauride, demonstrates that the global model, based on a felt conception of Greek tragedy, finds its place in the neo-classical movement

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Hadden, Robert David Martin. "Pathogenesis of Guillain-Barr syndrome." Thesis, King's College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394003.

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6

Zauner, Stefan. "Das Nucleomorph-Genom der Cryptomonade Guillardia theta." [S.l. : s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=962382272.

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Phongsisay, Vongsavanh, and vongsavang@yahoo com au. "Campylobacter jejuni and the Guillain-Barré syndrome." RMIT University. Applied Sciences, 2006. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20061221.100446.

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Campylobacter jejuni is an enteric bacterium that causes human gastroenteritis worldwide. Some C. jejuni strains exhibiting human ganglioside-like lipooligosaccharide (LOS) structures, such as GM1 ganglioside, can induce an autoimmune neuropathy of the peripheral nervous system known as the Guillain-Barré syndrome (GBS). This GBS-inducible determinant is encoded by a gene cluster, which shows a high degree of variation among C. jejuni strains. The experiments presented in this thesis were conducted to give a better insight into the LOS synthesis genes in relation to the pathophysiology of C. jejuni. Firstly, a C. jejuni strain without GM1-like molecules was shown to be able to take up large DNA fragments, including LOS synthesis genes, from a strain expressing GM1-like molecules and consequently be transformed into a number of potential GBS-inducible transformants, which exhibited a high degree of genetic and phenotypic diversity. The ability of C. jejuni to take up and integrate foreign DNA explains the genome plasticity observed in this pathogen. Secondly, while attempting to analyse transcription of the LOS gene cluster, neither published methods nor any commercially available kits for RNA isolation could produce DNA-free RNA from C. jejuni. Combinations of these methods were trialled and only the combination of RNAzolB, TURBO DNase treatment, and acid phenol extraction was able to produce DNA-free RNA. The RNA isolated from most C. jejuni strains showed different RNA patterns to that of other bacteria. In addition the RNA from C. jejuni seemed closely associated with DNA compaired to RNA from other organisms. This might be caused by species-specific DNA conformation or chromatin structure. Thirdly, bidirectional transcription was observed in the LOS gene cluster. Both DNA strands were transcribed but transcription of the non-coding strands was at a lower rate, and both sense and antisense transcripts of each LOS gene tested were responsive to acid stress. This unusual transcription might have a potential effect on the expression of the GBS-inducing determinant. Finally, one of the LOS genes, the htrB gene, was further analysed. It was shown that expression of the htrB gene affects morphology, viability, growth ability, and sensitivity to stress environments. These results showed that the LOS molecule of C. jejuni is involved in many processes and is an important molecule for survival.

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Mori, Izumi. "Syndrome de Guillain-Barré et perturbations immunitaires." Paris 6, 2008. http://www.theses.fr/2008PA066343.

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Le syndrome de Guillain–Barré (SGB) consiste en une atteinte auto–immune aiguë du système nerveux périphérique. L’infection déclenchant l’atteinte neurologique est souvent détectée, et la date du début de la maladie est connue. Notre hypothèse était que le profil de la réponse immunitaire pourrait influencer non seulement l’évolution naturelle de la maladie, mais également la sensibilité au traitement par immunoglobulines intraveineuses (IgIv). Nous proposons ici le premier biomarqueur de l’efficacité du traitement par IgIv au cours du SGB. Une forte proportion de cellules B matures circulantes permettrait de prédire une bonne réponse aux IgIv. Par ailleurs, les traitements par IgIv entraînent une impressionnante mobilisation de plasmocytes, associée à une récupération rapide. Pour finir, nous montrons que les patients les plus sévères et les moins sensibles aux IgIv présentaient plus volontiers une expansion de cellules T cytomégalovirus–spécifiques. Il découle donc de ces observations que l’immunomonitorage au cours du SGB pourrait renseigner non seulement sur la physiopathologie de cette affection, mais également sur sa sensibilité aux IgIv.

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Fok, Nga-yin Angel, and 霍雅妍. "Influenza vaccination and its association with Guillain-barréSyndrome." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45172043.

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Pritchard, Jane. "Immune responses to myelin proteins in Guillain-Barre syndrome." Thesis, King's College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414411.

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MICHELAT, CORINNE. "Les polyradiculonevrites aigues de l'enfant (syndrome de guillain-barre)." Clermont-Ferrand 1, 1992. http://www.theses.fr/1992CLF13002.

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Press, Rayomand. "Immunopathogenesis of Guillain-Barré syndrome and chronic inflammatory demyelinating polyradiculoneuropathy /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-378-3/.

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13

Tam, Clarence. "Campylobacter and other pathogens as causes of Guillain-Barre syndrome." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.429188.

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Van, der Merwe Hermanus Daniël. "A resonant mirror biosensor approach to understand antibody-antigen interactions in Guillain-Barré syndrome." Pretoria : [s.n.], 2007. http://upetd.up.ac.za/thesis/available/etd-04172008-111655/.

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Thesis (MSc Natural and Agricultural Sciences (Biochemistry))-University of Pretoria, 2007.
Summary in English and Afrikaans. Includes bibliographical references. Available on the Internet via the World Wide Web.

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Demestre, Maria. "The involvement of matrix metalloproteinases in the repair of the peripheral nervous system." Thesis, King's College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249685.

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Bowes, Tyrone Villalard. "The role of anti-ganglioside antibodies in the pathophysiology of autoimmune neuropathies." Thesis, Glasgow Caledonian University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270514.

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17

Merlet-Chicoine, Isabelle. "Aspects electrophysiologiques precoces du syndrome de guillain-barre : criteres pronostiques, a propos de 12 observations." Angers, 1991. http://www.theses.fr/1991ANGE1076.

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Charif, Mahmoud. "Les polyradiculonévrites aigues : étude rétrospective de 137 cas." Montpellier 1, 2000. http://www.theses.fr/2000MON11109.

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Rüdhmer-Dahle, Charlotte. "Studies on T cells and cytokines in Guillain-Barré syndrome and experimental allergic neuritis /." Linköping : Univ, 2001. http://www.bibl.liu.se/liupubl/disp/disp2001/med704s.pdf.

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Cheng, Qi. "Epidemiological and public health studies on Guillain-Barré syndrome in Sweden /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3908-X/.

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Sampaio, Pedro Henrique Marte de Arruda. "Assimetrias no exame neurológico de crianças com síndrome de Guillain-Barré." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/17/17161/tde-25042018-150422/.

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A Síndrome de Guillain-Barré (SGB) é uma neuropatia periférica inflamatória aguda que tem sido definida pelo achado ou história de tetraparesia flácida arreflexa ascendente. Apresentações atípicas podem ser mais frequentes do que tem sido referido na literatura, particularmente na faixa etária infantil. Objetivo: Avaliar dados epidemiológicos e a prevalência de assimetria no exame neurológico em crianças com SGB. Métodos: Foram revisados 40 prontuários de crianças de 0 a 15 anos de idade com o diagnóstico de SGB, atendidas entre janeiro de 2000 e agosto de 2016. Avaliouse a presença de assimetrias no exame neurológico na admissão hospitalar, os desfechos clínicos e as características demográficas e clinico-laboratoriais. Resultados: Dois pacientes apresentaram assimetria no exame neurológico na admissão hospitalar e três pacientes admitidos com tetraparesia simétrica apresentaram um quadro motor assimétrico antes da internação. Uma criança evoluiu para assimetria após ter sido admitida com quadro simétrico. Outros oito casos tinham fraqueza segmentar. A presença de assimetria motora ou fraqueza segmentar se correlacionou com a progressão estática dos sintomas (p=0,004) e observou-se uma tendência desses pacientes serem mais jovens, mas essa diferença não foi significativa (p=0,08). Onze pacientes apresentavam reflexos miotáticos preservados e um paciente exibia hiperreflexia na admissão hospitalar. A maioria dos pacientes foi admitida sem conseguir deambular e, na alta, a maioria deambulava com ou sem apoio. Cinco crianças necessitaram de suporte ventilatório e nenhuma foi a óbito. Conclusão: Uma proporção significativa dos pacientes apresentava quadro motor assimétrico ou segmentar e reflexos miotáticos preservados. Os resultados obtidos delineiam aspectos clínicos atípicos na SGB em crianças e podem ajudar na definição diagnóstica e instituição de tratamento precoce.
Guillain-Barré syndrome (GBS) is an acute, inflammatory, peripheral neuropathy that has been being defined as an ascending flaccid tetraparesis. Atypical presentations can be frequent, particularly in children, leading to greater challenges in the diagnosis. Objectives: To analyze the epidemiological data and the prevalence of motor asymmetries in the neurological examination of children with GBS. Methods: A total of 40 medical records were analyzed, of children aged 0 to 15 years old diagnosed with GBS, admitted from January 2000 to August 2016. We evaluated the presence of motor asymmetries at the hospital admission, the clinical outcomes and the demographic and clinic-laboratorial characteristics. Results: Two patients had motor asymmetries at hospital admission and three patients admitted with symmetric tetraparesis had an initial motor asymmetry before admission. One patient progressed to asymmetric tetraparesis after being initially admitted with symmetric weakness. Eight other cases had segmental weakness at admission. Motor asymmetry and segmental weakness correlated with a static progression of symptoms (p=0.004) and these patients tended to be younger, but this difference was not significant (p=0.08). Eleven patients had preserved deep tendon reflexes and one exhibited hyperreflexia at the hospital admission. Most patients were admitted on wheel-chair or bedridden, and at discharge the majority could walk with or without help. Five children required mechanical ventilation and no patient died. Conclusion: A significant proportion of patients had asymmetric or segmental weakness and preserved deep tendon reflexes. Those results show that the so-called atypical clinical findings in children with GBS are not uncommon, and needs to be kept in mind to allow an earlier diagnosis and treatment.

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Perez, Simone. "Fator neurotrófico ciliar e interleucina-6 na síndrome de Guillain-Barré." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2011. http://hdl.handle.net/10183/30980.

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A Síndrome de Guillain-Barré é uma polirradiculoneuropatia aguda imuno-mediada, clinicamente apresentando-se com envolvimento sensitivo e motor e curso progressivo, em muitos casos determinando grande incapacidade e morbimortalidade nos pacientes que a desenvolvem. Este projeto de pesquisa teve como objetivo o seguimento de uma coorte de 22 indivíduos portadores da Síndrome de Guillain-Barré admitidos no Hospital de Clínicas de Porto Alegre durante o período de Janeiro de 2008 a Dezembro de 2009 para a correlação dos achados clínicos com os níveis liquóricos de interleucina-6 (IL-6) e do fator neurotrófico ciliar do nervo (CNTF). Na admissão, foi coletado o líquido cefalorraquidiano dos pacientes para dosagem de IL-6 e CNTF e, após seis meses, os pacientes foram estratificados em dois grupos, de acordo com a escala de Hughes: bom e mau prognóstico. Não foi identificada associação entre esses níveis e os achados clínicos. Mesmo assim, acreditamos que o estudo dessas substâncias pode ajudar a esclarecer a fisiopatologia da Síndrome de Guillain-Barré.
The Guillain-Barré syndrome (GBS) is an acute polyradiculoneuropathy, which is usually immune-mediated. It is characterized by clinical features associated with a progressive motor and sensory involvement, leading often to major disability and morbidity in affected individuals. In this work, we investigate the correlation between clinical findings and cerebrospinal fluid levels of interleukine-6 (IL-6) and of ciliary neurotrophic factor (CNTF) in a cohort of patients with GBS during the period January 2008 - December 2009 at the Hospital de Clínicas in Porto Alegre. Interleukine-6 is an immune modulator produced in the immune system with the function of B-cells’ stimulation and antibody secretion. The CNTF is produced in the CNS and plays an important role in the survival of some types of neurons. In this regard, the clinical and prognostic correlation with cerebrospinal fluid may help to elucidate the physiopathology of the Guillain-Barré syndrome.

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Forsberg, Anette. "Guillain-Barré syndrome: disability, quality of life, illness experiences and use of healthcare /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-838-X/.

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Pontes, Tainá Madeira Barros. "Identificação etiológica de dengue em indivíduos com suspeita clínica da síndrome de Guillain Barré." Universidade de Fortaleza, 2017. http://dspace.unifor.br/handle/tede/108656.

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Made available in DSpace on 2019-03-30T00:18:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-09-27
Guillain-Barré Syndrome is a polyneuropathy characterized by weakness, often started in an acute way, which bilaterally affects the limbs in a symmetrical manner, although there are some cases with asymmetry. In two-thirds of the patients, the start of the symptoms is preceded by an infectious disease of the upper respiratory or gastrointestinal tract. In literature, there are reports showing that the dengue virus is the causal agent of this syndrome; that way, this research was to identify a presence of the dengue virus as an etiological agent in participants suspected of Guillain-Barré Syndrome in the State of Ceará. The study was performed in a tertiary hospital in the period from April 2016 to March 2017 by means of an active search for participants with clinical suspicion of Guillain-Barré Syndrome. Data collection took place during the hospital stay of the individuals through structured interviews, analysis of medical charts and collection of serum and/or cerebrospinal fluid samples from the participants. In this study, serological diagnoses for dengue (IgG and IgM) and molecular diagnoses were accomplished by using the RT-PCR technique. Of the 23 individuals with clinical suspicion of Guillain-Barré Syndrome, 22 were analyzed according to the inclusion criteria of the research. Of these 22 participants, 11 were diagnosed with Guillain-Barré Syndrome. After performing an IgM and RT-PCR serological test for dengue, four individuals showed positive IgM for dengue, two of them with diagnosis of Guillain-Barré Syndrome and one of them showed positive RT-PCR. The individual who showed positivity for dengue through the RT-PCR method during hospital stay concomitantly with neurological symptoms evolved with severity of the clinical picture, and then died. Therefore, we conclude that, probably, the dengue virus infection seems to be present in a higher proportion than expected, thereby suggesting a possible neglect of this etiology in the investigation of the cases of Guillain-Barré Syndrome in the State of Ceará. KEYWORDS: Guillain-Barré Syndrome; Dengue fever.
A Síndrome de Guillain-Barré é uma polineuropatia que se caracteriza por fraqueza, geralmente, de início agudo, acometendo bilateralmente os membros de forma simétrica, embora alguns casos apresentem assimetria. Em dois terços dos pacientes, o início dos sintomas é precedido por uma doença infecciosa do trato respiratório superior ou gastrointestinal. Há relatos na literatura do vírus dengue ser o agente causador da síndrome, dessa forma, o objetivo desta pesquisa foi identificar a presença do vírus dengue como agente etiológico em participantes suspeitos da Síndrome de Guillain-Barré no Estado do Ceará. O estudo foi realizado em um hospital terciário, durante os meses de abril de 2016 a março de 2017, através de busca ativa de participantes com suspeita clínica da Síndrome de Guillain-Barré. A coleta de dados ocorreu durante a internação do indivíduo, através de entrevista estruturada, por meio de análise de prontuários e coleta de amostras de soro e/ou líquido cefalorraquidiano dos participantes. Neste estudo, foram realizados diagnóstico sorológicos para dengue (IgG e IgM) e diagnóstico molecular através da técnica de RT-PCR. Dos 23 indivíduos com suspeita clínica da Síndrome de Guillain-Barré, 22 foram analisados conforme os critérios de inclusão da pesquisa. Desses 22 participantes, 11 foram diagnosticados com a Síndrome de Guillain-Barré. Após realizar teste sorológico para dengue IgM e RT-PCR, 4 indivíduos apresentaram IgM positivo para dengue, 2 desses com diagnóstico da Síndrome de Guillain-Barré e um deles apresentou RT-PCR positivo. O indivíduo que apresentou positividade para dengue, através do método RT-PCR, durante o internamento hospitalar concomitante aos sintomas neurológicos, evoluiu com gravidade do quadro e óbito. Portanto, concluímos que, provavelmente a infecção pelo vírus dengue parece estar presente em uma proporção maior que esperada, sugerindo possível negligência desta etiologia na investigação dos casos de Síndrome de Guillain-Barré em nosso Estado. PALAVRAS-CHAVE: Síndrome de Guillain-Barré; Dengue.

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GOURDIAT, ANNE. "Atteintes neurologiques au decours d'infections a campylobacter : cinq observations." Clermont-Ferrand 1, 1988. http://www.theses.fr/1988CLF13015.

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Barlaud, Véronique. "Les formes axonales des polyradiculonévrites inflammatoires." Bordeaux 2, 1995. http://www.theses.fr/1995BOR2M187.

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LAIRE, TACHE EMMANUELLE. "Echanges plasmatiques et syndrome de guillain-barre : experience remoise dans le cadre de l'etude multicentrique francaise prn 85." Reims, 1992. http://www.theses.fr/1992REIMM056.

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28

Cuvellier, Jean-Christophe. "Efficacite des immunoglobulines intraveineuses dans le syndrome de guillain-barre de l'enfant : comparaison a un groupe controle, 21 observations." Lille 2, 1991. http://www.theses.fr/1991LIL2M184.

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Dilley, Andrew James. "Serum factors as a cause of conduction block in Guillain-Barr syndrome." Thesis, King's College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400495.

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Coin, Nathalie Caudie Christiane. "Le syndrome de Guillain-Barré des mécanismes immunologiques aux nouvelles stratégies thérapeutiques /." [S.l.] : [s.n.], 2005. http://www.enssib.fr/bibliotheque/documents/dessid/rrbcoin.pdf.

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Rapport de recherche bibliographique de master professionnel 2e année : Ingénierie documentaire : Villeurbanne, ENSSIB : 2005. Rapport de recherche bibliographique de master professionnel 2e année : Ingénierie documentaire : Lyon 1 : 2005.
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Dourado, J?nior M?rio Em?lio Teixeira. "S?ndrome de Guillain-Barr?: epidemiologia, progn?stico e fatores de risco." Universidade Federal do Rio Grande do Norte, 2015. http://repositorio.ufrn.br/handle/123456789/20220.

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Indrodu??o. A S?ndrome de Guillain-Barr? (SGB) ? uma polineuropatia imunomediada, sendo, atualmente, a mais frequente causa de paralisia aguda neuromuscular. As principais variantes dessa s?ndrome s?o: a polineuropatia desmielinizante inflamat?ria aguda (PDIA), a neuropatia axonal motora aguda (NAMA), a neuropatia axonal motora e sensitiva aguda (NAMSA), e a s?ndrome de Miller-Fisher. H? tamb?m diferen?as na distribui??o geogr?fica destas variantes. A resposta imune aberrante, p?s infec??o, parece ser resultante de um mimetismo molecular, devido a forma??o de autoanticorpos e ativa??o do sistema complemento e de citocinas. S?o encontrados polimorfismos bial?licos nos genes codificadores dos receptores das fra??es Fc das imunoglobulinas (FcRIIa, FcRIIIa e FcRIIIb) que afetam a afinidade e efici?ncia na resposta imune celular, sugerindo a exist?ncia de susceptibilidade individual no risco de desenvolver a SGB. No Brasil, h? poucos estudos epidemiol?gicos sobre a SGB e nenhum relato sobre a frequ?ncia das variantes e suas manifesta??es cl?nicas. Os objetivos deste estudo foram: (1) caracterizar a SGB e suas manifesta??es cl?nicas em uma coorte de pacientes com SGB oriundos do Estado do Rio Grande do Norte (RN); (2) determinar se polimorfismos em receptores FcR est?o envolvidos com o risco de doen?a, e (3) avaliar a express?o g?nica global buscando identificar poss?veis vias que poderiam ser moduladas na fase inicial da doen?a e, consequentemente, diminuir o tempo de doen?a. Metodologia. Foram recrutados 149 casos de SGB diagnosticados entre 1994- 2013 no RN, tendo sido avaliados os dados cl?nicos e laboratoriais visando a determinar a evolu??o. DNA e RNA foram extra?dos do sangue perif?rico e anticorpos antiganglios?deos foram determinados em amostras de soro. Foram genotipados polimorfismos nos genes FCGR2A e FCGR3A, em pessoas com SGB (n=141) e controles saud?veis (n=364), sendo ainda analisadas as express?es g?nicas globais de 12 pacientes com SGB, por RNAseq. As amostras de sangue para os estudos de express?o g?nica foram coletadas ao diagn?stico e p?srecupera??o. Resultados. A incid?ncia de SGB foi de 0,3/100 mil pessoas no RN, sem presen?a de sazonalidade, com os casos ocorrendo em uma idade mais jovem. A SGB foi precedida por infec??es em 63,7%, sendo a diarreia associada a variante axonal (p=0,025). A PDIA foi a variante mais frequente (81,8%), seguida de NAMA (14,7%) e de NAMSA (3,3%). A distribui??o da fraqueza muscular correlacionou com as variantes, sendo a proximal mais frequente na PDIA, enquanto a distal predominou na variante axonal. O nadir < 10 dias ocorreu em 84,6% dos indiv?duos na variante axonal e 42,4% dos casos com PDIA (P<0,0001). A forma desmielinizante apresentou uma recupera??o na deambula??o mais r?pida do que a variante axonal (P<0,0001). A mortalidade de SGB foi de 5,3%. O pior progn?stico aos 12 meses estava associado com a variante axonal (OR 17,063; P = 0,03) e no tempo de melhora um ponto na escala funcional de Hughes (OR 1,028; P = 0.03). As distribui??es dos gen?tipos e alelos em FCGR2A (p=0,367) e em FCGR3A (p=0,2430) n?o foram diferentes entre os pacientes com SGB e controles. A an?lise da express?o g?nica global mostrou varia??o na express?o dos mRNAs de isoformas de prote?nas associadas ? fase sintom?tica da doen?a. Conclus?es. N?o h? sazonalidade na ocorr?ncia da SGB no RN, havendo um predom?nio da variante desmielinizante e 50% dos casos tinham idade inferior a 20 anos. A variante axonal est? associada ao mau progn?stico. O diagn?stico precoce e a identifica??o da variante, acompanhada de interven??es adequadas, levam a diminui??o da morbidade a longo prazo. Varia??es polim?rficas nos genes de FCGR parecem n?o influenciar a susceptibilidade ou o curso da SGB nessa popula??o. Varia??es na express?o g?nica apontam para vias de desregula??o e altera??es em intera??es transcricionais, que podem ser utilizadas como potenciais alvos de modula??o.
Introduction. Guillain-Barr? syndrome (GBS) is an immune-mediated polyneuropathy and the principal cause of acute neuromuscular paralysis. The most prominent GBS subtypes are: acute inflammatory demyelinating polyneuropathy (AIDP), acute motor axonal neuropathy (AMAN), acute motor-sensory axonal neuropathy (AMSAN) and Fisher syndrome (FS). Differences in geographical distribution of variants have been reported. In Brazil, there are few studies describing the characteristics of GBS, but none on the frequency of GBS variants and their clinical manifestations. Infection-induced aberrant immune response resulting from molecular mimicry and formation of cross-reacting antibodies, contribute to complement activation. Functional biallelic polymorphism in immunoglobulin receptors that influence the affinity of IgG subclasses and the type of immune response have been described, suggesting genetic susceptibility to developing disease. It remains unclear whether individuals carrying different FCGR alleles have differential risk for GBS and?or disease severity. The goals of this study were: (1) To characterize GBS and describe the clinical findings in a cohort of patients with GBS from the state of Rio Grande do Norte, Brazil; (2) to determine whether polymorphism in FCGR were associated with development of GBS, and (3) to tease out whether the global gene expression studies could be a tool to identify pathways and transcriptional networks which could be regulated and decrease the time of disease. Methods. Clinical and laboratory data for 149 cases of GBS diagnosed from 1994 to 2013 were analyzed. Genomic DNA and total RNA were extracted from whole blood. Antigangliosides antibodies were determined in the sera. In addition, we also assessed whether FCGR polymorphism are present in GBS (n=141) and blood donors (n=364), and global gene expressions were determined for 12 participants with GBS. Blood samples were collected at the diagnosis and post-recovery. Results. AIDP was the most frequent variant (81.8%) of GBS, followed by AMAN (14.7%) and AMSAN (3.3%). The incidence of GBS was 0.3 ? 100,000 people for the state of Rio Grande do Norte and cases occurred at a younger age. GBS was preceded by infections, with the axonal variant associated with episodes of diarrhea (P = 0.025). Proximal weakness was more frequent in AIDP, and distal weakness predominant in the axonal variant. Compared to 42.4% of cases with AIDP (P<0.0001), 84.6% of cases with the axonal variant had nadir in <10 days. Individuals with the axonal variant took longer to recover deambulation (P<0.0001). The mortality of GBS was 5.3%. A worse outcome was related to an axonal variant (OR17.063; P=0.03) and time required to improve one point in the Hughes functional scale (OR 1.028; P=0.03). The FCGR genotypes and allele frequencies did not differ significantly between the patients with GBS and the controls (FCGR2A p=0.367 and FCGR3A p=0.2430). Global gene expression using RNAseq showed variation in transcript coding for protein isoforms during acute phase of disease. Conclusions. The annual incidence of GBS was 0.3 per 100,00 and there was no seasonal pattern. A predominance of the AIDP variant was seen, and the incidence of the disease decreased with age. The distribution of weakness is a function of the clinical variants, and individuals with the axonal variant had a poorer prognosis. Early diagnosis and variant identification leads to proper intervention decreasing in long-term morbidity. FCGR polymorphisms do not seem to influence susceptibility to GBS in this population. This study found deregulated genes and signs of transcriptional network alterations during the acute and recovery phases in GBS. Identification of pathways altered during disease might be target for immune regulation and with potential to ameliorate symptoms.

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Maire, Olivier. "Avenir fonctionnel et rééducation du syndrome de Guillain et Barré d'évolution prolongée." Montpellier 1, 1991. http://www.theses.fr/1991MON11176.

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Torres, Vitor Félix. "Níveis séricos e liquóricos da proteína S100B, enolase específica do neurônio e neurotrofinas na síndrome de Guillain-Barré." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2010. http://hdl.handle.net/10183/26920.

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A Síndrome de Guillain-Barré é caracterizada por uma polirradiculoneuropatia de instalação aguda, usualmente imuno-mediada, com características clínicas associado a um envolvimento sensitivo e motor progressivo, muitas vezes determinando grande incapacidade e morbimortalidade nos indivíduos acometidos pela doença. Este projeto de pesquisa teve como objetivo o seguimento de uma coorte de indivíduos portadores da Síndrome de Guillain-Barré admitidos no Hospital de Clínicas de Porto Alegre durante o período de Janeiro de 2008 à Dezembro de 2009 para a correlação dos achados clínicos com os níveis plasmáticos e liquóricos da proteína S100B. A proteína S100B é basicamente encontrada nos astrócitos e tem tido grande importância para o melhor entendimento dos processos fisiopatológicos na injúria do Sistema nervoso central. Alguns autores relataram a correlação entre a Síndrome de Guillain-Barré e os níveis liquóricos da proteína S100B, baseado nestas descrições acreditamos que o melhor entendimento fisiopatológico da Síndrome de Guillain-Barré associado a determinação dos níveis plasmáticos e liquóricos da proteína S100B possam auxiliar e estabelecer uma importante ferramenta prognóstica precoce na determinação da gravidade dos portadores da Síndrome de Guillain-Barré.
The Guillain-Barre syndrome is characterized by a polyradiculoneuropathy of acute onset, usually immune-mediated, with clinical features associated with a progressive motor and sensory involvement, often determining major disability and morbidity in individuals affected by this disease. This research Project was aimed at following a cohort of patients with Guillain-Barre syndrome admitted to the Hospital de Clinicas de Porto Alegre during the period of January 2008 to December 2009. We measured the sera and cerebrospinal fluid (CSF) concentrations of S100B protein, neuron-specific enolase, neurotrophins and interleukin 6 using enzyme immunoassay methods in 22 patients with Guillain- Barre syndrome and 32 controls. The clinical and laboratory findings observed in the cases were important for better understanding of the pathophysiology of this disease coupled with the outcome of disabilities among the cases.

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CORBARIEU, PERRAULT JOELLE. "Le traitement du syndrome de guillain barre en pediatrie : etude retrospective soins conventionnels versus echanges plasmatiques ; a propos de 24 cas." Toulouse 3, 1994. http://www.theses.fr/1994TOU31056.

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Marliere, Christine. "Le synrome de fisher." Amiens, 1989. http://www.theses.fr/1989AMIEM058.

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MIESCH, BARBARA. "Neuropathies aigues a forme axonale : une nouvelle entite ?" Université Louis Pasteur (Strasbourg) (1971-2008), 1993. http://www.theses.fr/1993STR1M156.

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Rees, Jeremy Harry. "An investigation into the association between Campylobacter jejuni infection and Guillain-Barre syndrome." Thesis, King's College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.281775.

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Gries, Manuela [Verfasser], and Tobias [Akademischer Betreuer] Hartmann. "Die Bedeutung angeborener Immunrezeptoren beim experimentellen Guillain-Barré-Syndrom / Manuela Gries. Betreuer: Tobias Hartmann." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2013. http://d-nb.info/1052904904/34.

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Braun, Anne. "Syndrome de Guillain-Barre et grossesse : à propos d'un cas : revue de la littérature." Université Louis Pasteur (Strasbourg) (1971-2008), 1986. http://www.theses.fr/1986STR1M149.

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Chetty, Sarvani. "Guillain Barre Syndrome (GBS) in Cape Town, South Africa: a descriptive outcomes cohort study." Master's thesis, Faculty of Health Sciences, 2019. http://hdl.handle.net/11427/31166.

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INTRODUCTION Guillain-Barré syndrome (GBS) or acute inflammatory demyelinating polyradiculoneuropathy (AIDP) is an important cause of acute severe and life-threatening weakness. It occurs worldwide and may affect all age groups, but varies widely in clinical presentation, subtype, electrophysiology, course and outcome. There is sparse literature on GBS in low and middle income countries (LMIC), and the effect, if any, of HIV on GBS. This observational cohort study aims to describe the clinical presentation and outcome of acute GBS in Cape Town, South Africa, in participants recruited into the International Guillain-Barré Syndrome Outcome Study (IGOS). A secondary aim, given the high HIV prevalence in South Africa, is to describe and compare GBS participants with and without HIV infection. METHODS Between 1 June 2014 and 31 January 2017, we recruited participants 18 years or older presenting to Groote Schuur Hospital in Cape Town with acute GBS (< 2 weeks onset of symptoms) who were available for 1 year follow up. We recorded demographic, clinical, laboratory, electrophysiological and treatment data at entry. At follow-up at weeks 4, 26 and 52, GBS-related complications and GBS disability scale scores (GDSs) were evaluated. A good outcome was defined as the ability to walk unaided (GDSs 2) by 6 months. The clinical presentation and outcomes of HIV-uninfected and -infected participants were compared. RESULTS: Of 31 recruited participants, 1 participant was re-diagnosed as acute onset-CIDP and excluded from the study and 1 participant demised of an unrelated cause within the first week. 19 participants were male and the median age was 40 years. Reported antecedent infections (73%), co-morbid HIV infection (30%) and tuberculosis (15%) were frequently seen. Acute inflammatory demyelinating polyradiculoneuropathy (AIDP; 67%) and acute motor axonal neuropathy (AMAN; 17%) were the most common phenotypes. Overall, GBS-related complications occurred in 46% of participants. The major complication was pneumonia which occurred in 23% of the total group, and all required intubation/ventilation. Other septic complications (drip site or systemic) were less common, 6% of the entire group. At entry, 83% had GDSs >4 indicating severe disability. The ability to walk unaided was regained by 37% at 4 weeks, 75% at 6 months and 79% at 1 year. Three participants remained severely affected at 1 year (GDSs of >3). There were no differences in antecedent infections, treatments given, or motor outcomes between HIV-infected and -uninfected GBS participants apart from a trend towards higher CSF protein in the HIV-infected group (p-value 0.05). AIDP was the most common GBS variant in both groups. AMAN was only seen in the HIV-uninfected group, whereas Miller Fisher 5 syndrome (MFS) was more common in the HIV-infected group. However, the numbers were too small to reach statistical significance. CONCLUSION Infections with HIV and tuberculosis frequently co-occurred with acute GBS, whether this reflects true disease association or merely high background disease prevalence cannot be confirmed by this study. AIDP is the most common phenotype unlike other LMIC regions such as Asia where AMAN predominates. In this cohort, 76% of participants showed good outcomes being able to walk unaided or having no/minor symptoms by 6 months. However, of the remainder only 1 showed significant recovery at 1 year. HIV participants had similar clinical presentations, complications and outcomes compared to the HIV-uninfected group. Mortality was low.

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BOULESTEIX, AUBERT MARIE-ANGE. "Depistage des anomalies de la conduction proximale par stimulations etagees du nerf cubital au cours du syndrome de guillain-barre." Limoges, 1989. http://www.theses.fr/1989LIMO0174.

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Guilliard, Nicole [Verfasser], and Jörg [Akademischer Betreuer] Starflinger. "Entwicklung eines gekoppelten Neutronik-Thermohydraulik-Codes zur Untersuchung von Störfällen in schnellen Natrium gekühlten Reaktoren / Nicole Guilliard ; Betreuer: Jörg Starflinger." Stuttgart : Universitätsbibliothek der Universität Stuttgart, 2017. http://d-nb.info/1147381526/34.

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Blomberg, Carolina. "Intrathecal and Systemic Complement Activation Studies of Multiple Sclerosis and Guillan-Barré Syndrome." Thesis, University of Kalmar, School of Pure and Applied Natural Sciences, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:hik:diva-2032.

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Both Multiple Sclerosis (MS) and Guillan-Barré syndrome (GBS) are neurological inflammatory demyelinating autoimmune diseases, with a probable antibody contribution. Complement proteins in both MS and GBS does play a role in inflammation and demyelination at pathogenesis, according to earlier scientific evidence. The aim of this examination project work was to investigate systemic and intrathecal complement activation in MS and GBS, to gain further knowledge that might be useful for development of future therapeutics targeting immune responses during those diseases. An additional aim was to develop a new ELISA method for detection of complement iC3.

By using sandwich ELISA, complement proteins C1q, C4, C3, fH and C3a were measured in plasma and cerebrospinal fluid (CSF) from persons within 4 different diagnostic groups; MS, other neurological diseases (OND), GBS and controls (C). An ELISA method to detect iC3 (hydrolysed C3) was also developed, including usage of SDS-PAGE. Results based on raw data and statistical analysis show significantly elevated levels of C3a (C3a/C3) in MS and decreased C3 in plasma. In CSF low levels of C4 and C3a/C3 in MS were detected, though correlation of C3a and C1q was positive. GBS reveal high levels of all complement proteins analysed in CSF except for C3, and a positive correlation of C3a and C1q as well as C3a and fH was found.

These results indicate that MS patients have systemic complement activation; however the activation pathway is not determined. Complement activation in MS may also occur intrathecally, with correlation analysis indicating a possible activation via the classical pathway. MS patients suffering from a more acute relapsing-remitting (RR) MS have a more prominent systemic complement activation compared to MS patients responding to beta-interferon treatment. Systemic increased C3a/C3 ratio may be a possible biomarker to distinguish more acute RR MS in an earlier step of MS pathogenesis and should be further investigated. GBS patients have an intrathecal complement activation that seems to occur via the classical pathway.

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Greenshields, Kay. "Pathogenic potential of anti-ganglioside antibodies in a murine model of axonal Guillain-Barré syndrome." Thesis, University of Glasgow, 2007. http://theses.gla.ac.uk/3760/.

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Guillian-Barré Syndrome (GBS) is the world’s leading cause of neuromuscular paralysis occurring in serologically and pathogenically distinct forms. GBS is believed to have an autoimmune basis, where antibodies raised during antecedent infections (eg Campylobacter jejuni) cross-react with self antigens, exemplifying the process of molecular mimicry. These self-antigens are gangliosides, which are glycolipid structures enriched in peripheral nerve in specific membrane compartments termed lipid rafts. To date, successful murine models of anti-GD1a and anti-Gq1b ganglioside mediated neuropathy exist. Clinical evidence supports the involvement of anti-GM1 antibodies in nerve injury, however generation of anti-GM1 antibody mediated neuropathy models remain an enigma, and to date, the only successful model is based in Japanese rabbits. This thesis aims to address the controversies surrounding anti-GM1 antibody mediated neuropathy by utilising a panel of anti-GM1 antibodies of differing specificity, and explores how the stereometric interactions of GM1 with lipid raft species underpin the pathogenic potential of these antibodies.

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Britto, Alexandre Paulo Machado de. "Custo-efetividade do uso de imunoglobulina intravenosa e de plasmaferese no tratamento da síndrome de Guillain-Barré no Hospital de Clínicas de Porto Alegre." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2009. http://hdl.handle.net/10183/148859.

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Objetivo: Comparar as relações de custo-efetividade de duas terapias, Imunoglubulina Intravenosa (IgIV) e Plasmaferese (PE), no tratamento da Síndrome de Guillain-Barré sob a perspectiva do sistema público (SUS). O objetivo secundário foi avaliar a adesão às recomendações da Comissão de Medicamentos do HCPA Métodos: estudo transversal com análise econômica de pacientes tratados por Síndrome de Guillain-Barré no período de junho de 2003 a junho de 2008 no Hospital de Clínicas de Porto Alegre (HCPA). Foi realizada análise de custo-efetividade do emprego de IgIV e de PE nestes pacientes, pelo método de minimização de custos, considerando-se somente os custos diretos sanitários, fornecidos pelo sistema gerencial da instituição . Foram excluídos os pacientes que usaram outro tipo de tratamento associado ou isolado. Coletaram-se os dados através da revisão dos prontuários. A gravidade da doença na internação foi classificada como: doença leve, quando caminhar foi possível; doença moderada, quando caminhar foi impossível; doença grave, quando os pacientes necessitaram de ventilação assistida. A incapacidade na alta foi estabelecida pela escala de sete pontos de Hughes. A adesão às recomendações da Comissão de Medicamentos do HCPA, objetivo secundário, foi avaliada através da dose e o esquema de prescrição da IgIV. Resultados: Vinte e cinco participantes (2 a 70 anos) foram incluídos no estudo, cinco tratados com PE, empregando-se Albumina Humana como substituto do plasma, e 20 tratados com IgIV. O custo total do tratamento de um paciente com PE foi R$10.603,88 (± 2.978,12) e o de um que recebeu IgIV foi R$ 32.103,00 (± 21.454,24). O custo total da internação foi de R$45.027,14 (± 32.750,45) para os tratados com PE e de R$ 60.844,28 (±48.590,52) para os que receberam IgIV. Em relação ao desfecho clínico principal, melhora na escala de incapacidade de sete pontos, após o tratamento com uma das alternativas escolhida, a mediana dos pacientes que internaram com grau de gravidade 3 e que foram tratados com PE foi igual a dos que receberam IgIV. Em relação à permanência hospitalar, permanência em UTI e dias de Ventilação Mecânica, não houve diferença estatisticamente significativa entre os dois tratamentos. Conclusões: Quando comparados os custos médios das duas opções terapêuticas, uma delas aparece claramente com menor custo. Quando comparados os desfechos, após o emprego de cada opção terapêutica, estes não revelam diferença. Concluímos que, no HCPA, a opção pelo procedimento Plasmaferese é mais custo efetiva do que o emprego da IgIV.
Objectives: To compare the cost-effectiveness of two distinct therapies, Intravenous Immunoglobulin (IVIg) and Plasma Exchange (PE) in the treatment of Guillain-Barré Syndrome, concerning the public health care system. Compliance to the guidelines of the Pharmacy and Therapeutics Committee of the Hospital de Clínicas de Porto Alegre was a secondary objective. Methods: A cross-sectional, economical analysis was conducted, including patients treated for GBS in the period from June, 2003 through June, 2008 in Hospital de Clínicas de Porto Alegre (HCPA). The cost-effectiveness of the use of IVIg and PE in such patients was studied through the cost minimization method, considering direct medical costs only (2008 currency), yield by the management of the institution. Patients receiving treatments other than PE or IVIg were excluded. Data were collected by chart reviews. Severity of disease on admittance was classified as follows: mild disease, when the patient was able to walk; moderate disease, when the patient was unable to walk, and severe disease, when assisted ventilation was required. Disability on discharge was established by the 7-point scale of Hughes. Compliance to the guidelines of the Pharmacy and Therapeutics Committee was evaluated through the dose and prescription scheme of IVIg. Results: Twenty-five participants (2 to 70 years of age) were included in the study, 5 were submitted to treatment with PE, using human albumin as replacement for plasma, and 20 were treated with IVIg. The total treatment cost for PE in a single patient was US$6,058.85 (±1,701.78 SD), and the same expense for IVIg was US$18,344.57 (± 12,259.56 SD) (p = 0.035). Total inpatient cost was US$25,729.79 (± 18,714.54 SD) in the PE group, and US$34,768.16 (±27,766.01 SD) (p=0.530) in the IVIg group. The main clinical outcome was improvement in the 7-point disability grade scale. The median of that measure in patients admitted with a severity grade 3 treated either with PE and IVIg was the same. Secondary outcomes, such as in-hospital stay, ICU stay, and number of days on mechanical ventilation revealed no statistically significant difference between treatments. Conclusions: As the mean expenses of both therapeutic options are compared, one clearly stands-out as less onerous. Clinical outcomes, when compared, reveal no statistical difference after each treatment. We concluded that, in HCPA, plasma exchange is more cost-effective than intravenous immunoglobulin.

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Guillemard, Mijail [Verfasser], and Armin [Akademischer Betreuer] Iske. "Some Geometrical and Topological Aspects of Dimensionality Reduction in Signal Analysis / Mijail Guillemard. Betreuer: Armin Iske." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2012. http://d-nb.info/1022196510/34.

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Krause, Julia [Verfasser]. "Therapie des Guillain Barré Syndroms: Unterschiede im Therapieansprechen unter Plasmapherese im Vergleich zur Immunglobulingabe / Julia Krause." Kiel : Universitätsbibliothek Kiel, 2016. http://d-nb.info/1122110995/34.

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McLean, Mark Edward. "The incidence of Guillain-Barre syndrome in Ontario and Quebec, 1983-1989, using hospital-service databases." Thesis, University of Ottawa (Canada), 1992. http://hdl.handle.net/10393/7478.

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Background. Guillain-Barre syndrome (GBS) is of public health interest in Canada, as well as the rest of North America, for two main reasons. It is occasionally a vaccine-associated adverse event and is also a differential diagnosis of poliomyelitis. Objectives. (1) To ascertain the incidence of GBS in the Canadian provinces of Ontario and Quebec for the years 1983-1989, inclusive. (2) To demonstrate the feasibility of measuring the incidence of GBS through internal record linkage of Canadian hospital-service data. Results. 1,302 and 1,031 records representing GBS incident admissions in Ontario and Quebec, respectively, were identified through the record-linkage procedure. The mean annual GBS incidence after age-and-sex-standardization to the 1986 Canadian census population was 2.02 per 100,000 person-years in Ontario and 2.30 in Quebec. The incidence was higher in older age-strata in both provinces (70-80 years), and was higher in males (M:F = 1.1). Reviews of charts of incident admissions of GBS cases reveal that 26.2%-32.6% of Ontario cases and 21.0%-24.0% of Quebec cases may be false positive diagnoses. No possible false negative cases were identified through chart review. Cross linkage of records belonging to the other province with records from the other dataset revealed 0.5% false negative misclassification of Ontario incident admissions and 1.8% for Quebec. Mortality figures obtained from CMDB were in both provinces less than those obtained in the hospital service data, indicating that it is unlikely a significant number of GBS cases die before reaching hospital. Conclusions. (1) It is possible to internally link records in the HMRI and Med-Echo databases into personal histories (cases) of a condition. (2) The high percentage of false positive misclassifications discovered on examination of incident admissions raises concern about the validity of HMRI and Med-Echo data for epidemiological purposes. (Abstract shortened by UMI.)

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Guillemard, Mijail Verfasser], and Armin [Akademischer Betreuer] [Iske. "Some Geometrical and Topological Aspects of Dimensionality Reduction in Signal Analysis / Mijail Guillemard. Betreuer: Armin Iske." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2012. http://nbn-resolving.de/urn:nbn:de:gbv:18-56358.

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Füss, Robert. "Der Zusammenhang neurologischer Systemerkrankungen mit Befunden der Energetischen Terminalpunkt-Diagnose (E-T-D) nach Mandel, Kirlian-Fotografie : eine Diagnose-Evaluation am Beispiel des Guillain-Barré-Syndroms und der Multiplen Sklerose /." Hochheim : CO'MED-Verl.-Ges, 2007. http://d-nb.info/986160571/04.

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Dissertations / Theses on the topic 'Guillard'

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