Log in

Relevant bibliographies by topics / Guinea pigs Anatomy / Journal articles

To see the other types of publications on this topic, follow the link: Guinea pigs Anatomy.

Journal articles on the topic 'Guinea pigs Anatomy'

Author: Grafiati

Published: 4 June 2021

Last updated: 2 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Guinea pigs Anatomy.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Goksu, Nebil, Nalan Karademir, Rifki Haziroglu, Ismet Bayramoglu, Yusuf Kemaloglu, and Necmettin Akyeldiz. "Anatomy of the Guinea Pig Temporal Bone." Annals of Otology, Rhinology & Laryngology 101, no. 8 (August 1992): 699–704. http://dx.doi.org/10.1177/000348949210100814.

Full text

Abstract:

The middle ear of guinea pigs has long been used for experimental studies, but no detailed information about its temporal bone anatomy is available. In 18 adult guinea pigs, the temporal bone, eustachian tube, and inner ear anatomy, in addition to the anatomy of the middle ear, were investigated under the dissection microscope. In addition to properties of the eardrum, ossicles, air cell system, and cochlea previously described, the appearance of Huschke's foramen and the crista stapedis in an adult guinea pig ear, the structure of the eustachian tube, the architecture of the internal auditory canal, and the communication of the mastoid cells with the tympanic bulla are described. Differences and similarities among guinea pigs, other experimental animals, and humans are discussed to show the advantages and disadvantages of the guinea pig ear for experimentation.

APA, Harvard, Vancouver, ISO, and other styles

2

Aharinejad, S., P. Franz, H. Sinzinger, and W. Firbas. "Esophageal Prostaglandins in Guinea Pigs and Rats." Cells Tissues Organs 139, no. 1 (1990): 66–69. http://dx.doi.org/10.1159/000146980.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Yarto-Jaramillo, Enrique. "Respiratory System Anatomy, Physiology, and Disease: Guinea Pigs and Chinchillas." Veterinary Clinics of North America: Exotic Animal Practice 14, no. 2 (May 2011): 339–55. http://dx.doi.org/10.1016/j.cvex.2011.03.008.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Legendre, Loic. "Anatomy and Disorders of the Oral Cavity of Guinea Pigs." Veterinary Clinics of North America: Exotic Animal Practice 19, no. 3 (September 2016): 825–42. http://dx.doi.org/10.1016/j.cvex.2016.04.006.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Maxeiner, Stephan, Selina Gebhardt, Frederick Schweizer, Agnes E. Venghaus, and Gabriela Krasteva-Christ. "Of mice and men – and guinea pigs?" Annals of Anatomy - Anatomischer Anzeiger 238 (November 2021): 151765. http://dx.doi.org/10.1016/j.aanat.2021.151765.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Alp, H., B. Durgun, S. Müftüoğlu, S. Inan, and E. Aşan. "Ultrastructural Changes of Epidermal Langerhans Cells in Pregnant Guinea Pigs." Cells Tissues Organs 149, no. 2 (1994): 100–103. http://dx.doi.org/10.1159/000147563.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

de Faria, Marcelo, Adriana Gradela, Ana Santos, Ítalo Lopes, Vanessa Inoue, and Bárbara Brito. "Participation of the Intercostal Nerves to the Innervation of the Diaphragm Muscle in Cavia porcellus." Journal of Morphological Sciences 36, no. 01 (March 2019): 024–27. http://dx.doi.org/10.1055/s-0039-1683406.

Full text

Abstract:

Introduction The diaphragm is the leading respiratory muscle. It is innervated mainly by the diaphragmatic nerve, and, in some species, by the delicate fibers of the intercostal nerves. In guinea pigs, there is no description of these anatomic structures that innerve this important muscle. This study aimed to analyze the participation of the intercostal nerves to the innervations of the diaphragm of guinea pigs of both sexes. Materials and Methods We studied 40 guinea pigs (Cavia porcellus) of both sexes. We fixed and dissected the diaphragm of the specimens used in the experiment to assess the path of the intercostals nerves in both the body antimeres. Results The diaphragm was innervated by the intercostal nerve pairs 6 through 12, and, less frequently, by the 8th nerve (38/40 = 95%), followed by the 7th (36/40 = 90%) and subsequently by the 9th (32/40 = 80%). The 12th nerve presented the lowest frequency (2/20 = 10%) in both genders. All nerve pairs displayed similar occurrence compared with the gender and the antimeric disposition. The only exception was the 9th nerve, which presented a significant variation of the occurrence, both in relation to gender and antimeric disposition. From a statistic point of view, all nerves were independent. We observed no correlation between the gender and their position. Conclusions We shall conclude that the diaphragm of guinea pigs is innervated by the 6th through 12th pairs of intercostal nerves, with the 7th, 8th, and 9th being the primary providers. There is no interference of the variables gender or antimeric disposition on the behavior of the intercostal nerves of guinea pigs as refers to their origin and participation to the innervations of the diaphragm.

APA, Harvard, Vancouver, ISO, and other styles

8

Lohse, C. L., K. L. Cox, A. T. W. Cheung, and J. A. Negulesco. "Effects of Growth and Maturation on Biliary Structures of Guinea Pigs." Cells Tissues Organs 128, no. 3 (1987): 177–83. http://dx.doi.org/10.1159/000146336.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Ghiz, Adam F., Alec N. Salt, John E. DeMott, Miriam M. Henson, O. William Henson, and Sally L. Gewalt. "Quantitative anatomy of the round window and cochlear aqueduct in guinea pigs." Hearing Research 162, no. 1-2 (December 2001): 105–12. http://dx.doi.org/10.1016/s0378-5955(01)00375-6.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Zeng, L., M. Takeya, X. Ling, A. Nagasaki, and K. Takahashi. "Interspecies reactivities of anti-human macrophage monoclonal antibodies to various animal species." Journal of Histochemistry & Cytochemistry 44, no. 8 (August 1996): 845–53. http://dx.doi.org/10.1177/44.8.8756757.

Full text

Abstract:

We examined interspecies reactivities of eight anti-human monocyte/macrophage monoclonal antibodies (MAbs), Am-3K, PM-2K, X4, X14, Ber-MAC3, GHI/61, EBM/11, and KP1, with various animal tissues including rats, guinea pigs, rabbits, cats, dogs, goats, pigs, bovines, horses, and monkeys. All MAbs recognized monkey macrophages. Pig macrophages were detected by most MAbs except for EBM/11 and KP1. Of the eight antibodies, AM-3K showed the widest interspecies reactivity. It reacted with macrophages of all animal species examined, except for rats. Western blot analysis revealed a similarity in the antigens recognized by AM-3K among guinea pigs, rabbits, and humans. Other anti-human MAbs demonstrated distinct reactive patterns against macrophages in animals. The immunostaining patterns of all of these MAbs in animal tissues were similar to those found in humans, although some MAbs, such as AM-3K, EBM/11, and X4, displayed more restricted reactivity in animals than in humans. These results indicate that some anti-human monocyte/macrophage MAbs are also available for immunohistochemical detection of monocyte/macrophages in animal tissues. Among them, AM-3K is considered to be the most useful MAb for identifying macrophages in various tissues of animals.

APA, Harvard, Vancouver, ISO, and other styles

11

Johansson, Jan-Olof. "The Lamina cribrosa in the Eyes of Rats, Hamsters, Gerbils and Guinea Pigs." Cells Tissues Organs 128, no. 1 (1987): 55–62. http://dx.doi.org/10.1159/000146315.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Qayyum, M. A., J. A. Fatani, and M. G. El-Badawi. "Partial Degeneration of Autonomic Nerves of the Heart of Methotrexate-Treated Guinea Pigs." Cells Tissues Organs 131, no. 1 (1988): 52–55. http://dx.doi.org/10.1159/000146485.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Kanoh, Naoyuki. "Cytochemical Localization of Ouabain-sensitive, K+-dependent p-nitrophenylphosphatase Activity in the Facial Nerve of Reserpinized Guinea Pigs." Journal of Histochemistry & Cytochemistry 45, no. 8 (August 1997): 1129–35. http://dx.doi.org/10.1177/002215549704500810.

Full text

Abstract:

Ion-transporting Na,K-ATPase plays an essential role in nerve conduction. To clarify the cytochemical effects of reserpine on transport Na,K-ATPase activity, the localization of ouabain-sensitive, K+-dependent p-nitrophenylphosphatase (K-NPPase) activity was investigated in the facial nerves of normal and reserpinized guinea pigs using a cerium-based method. In the normal facial nerve, the reaction product of K-NPPase activity was observed on the internodal axolemma and Schmidt-Lanterman incisures. In the Ranvier nodes, enzyme activity was localized to the paranodal and nodal axolemma. In the reserpinized nerves, reaction product was detectable on the nodal axolemma but was undetectable on the other parts of the axolemma. Nodal K-NPPase was not affected by reserpine treatment. Therefore, the transport Na,K-ATPase on the nodal axolemma might differ from that on the other parts of the axolemma. Allowing reserpinized animals to survive. Two different ouabain-sensitive K-NPPase reactivities, “reserpine-sensitive” and “reserpine-resistant,” might be present in the facial nerve of guinea pigs. (J Histochem Cytochem 45:1129–1135, 1997)

APA, Harvard, Vancouver, ISO, and other styles

14

Dayan, M. O., K. Beşoluk, E. Eken, S. Aydoğdu, and N. Turgut. "Three-dimensional modelling of the femur and humerus in adult male guinea pigs (guinea pig) with computed tomography and some biometric measurement values." Folia Morphologica 78, no. 3 (August 29, 2019): 588–94. http://dx.doi.org/10.5603/fm.a2019.0002.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Karimi, Isaac, Lora A. Becker, Ali Jalili, and Mohammadmehdi Hadipour. "Gender-dependent effects of fluoxetine on selected biochemical parameters in guinea pigs." Comparative Clinical Pathology 21, no. 6 (August 24, 2011): 1501–7. http://dx.doi.org/10.1007/s00580-011-1319-z.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Larkin, L. H., D. E. Welch, S. Ogilvie, and L. Wubbel. "Cytochemical detection of carbohydrate and immunocytochemical detection of relaxin in the same secretory granule." Journal of Histochemistry & Cytochemistry 35, no. 6 (June 1987): 693–97. http://dx.doi.org/10.1177/35.6.3553319.

Full text

Abstract:

We administered estradiol and progesterone to spayed guinea pigs, with resultant accumulation of secretory granules in endometrial gland cells. By initially employing protein A-colloidal gold immunolocalization of relaxin, followed by cytochemical staining of carbohydrate with the thiocarbohydrazide-silver proteinate method on the same section, we showed clearly that the secretory granules were composed of a central core containing relaxin and a cortex of carbohydrate-rich material. Use of normal rabbit serum rather than relaxin antiserum, and omission of periodic acid, demonstrated the specificity of the technique.

APA, Harvard, Vancouver, ISO, and other styles

17

Osborne, Michael P., and Spiro D. Comis. "High resolution scanning electron microscopy of stereocilia in the cochlea of normal, postmortem, and drug-treated guinea pigs." Journal of Electron Microscopy Technique 15, no. 3 (July 1990): 245–60. http://dx.doi.org/10.1002/jemt.1060150305.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Masutani, Mamoru, and Ken Hashimoto. "Phagocytic and lysosomal activity in Langerhans cells from sensitized guinea pigs." Medical Electron Microscopy 29, no. 2 (November 1996): 55–69. http://dx.doi.org/10.1007/bf02349041.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Kameda, Yoko. "Occurrence of colloid-containing follicles and ciliated cysts in the hypophysial pars tuberalis from guinea pigs of various ages." American Journal of Anatomy 188, no. 2 (June 1990): 185–98. http://dx.doi.org/10.1002/aja.1001880208.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Ohtani, Osamu, and Quan-Xin Wang. "Comparative analysis of insulo-acinar portal system in rats, guinea pigs, and dogs." Microscopy Research and Technique 37, no. 5-6 (June 1, 1997): 489–96. http://dx.doi.org/10.1002/(sici)1097-0029(19970601)37:5/6<489::aid-jemt11>3.0.co;2-m.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Uchida, T., and T. Endo. "Immunoelectron microscopic demonstration of S-100b protein-like in centriole, cilia, and basal body." Journal of Histochemistry & Cytochemistry 36, no. 6 (June 1988): 693–96. http://dx.doi.org/10.1177/36.6.3367052.

Full text

Abstract:

We report here the ultrastructural localization of S-100b protein-like immunoreactivity in the centriole, cilia, and basal body. Duodenum and trachea of guinea pigs and rats were fixed and immunostained by the protein A-gold method. All centrioles, cilia, and basal bodies observed showed clear S-100b protein-like immunoreactivity. Specific colloidal gold particles were located over the microtubules in these cell organelles. However, other microtubules scattered throughout the cytoplasm were devoid of immunoreactivity. Although the functional significance of S-100b protein-like immunoreactivity in the centriole, cilia, and basal bodies remains to be elucidated, the present results introduce new perspectives into the investigation of localization and function of S-100 proteins.

APA, Harvard, Vancouver, ISO, and other styles

22

Aharinejad, S., P. Franz, W. Firbas, and M. Fakhari. "Mandibular and molar vascularization in guinea pigs. Scanning electron microscopic study of corrosion casts." Anatomical Record 228, no. 4 (December 1990): 471–77. http://dx.doi.org/10.1002/ar.1092280414.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Campbell, Scott E., A. Martin Gerdes, and Teri D. Smith. "Comparison of regional differences in cardiac myocyte dimensions in rats, hamsters, and guinea pigs." Anatomical Record 219, no. 1 (September 1987): 53–59. http://dx.doi.org/10.1002/ar.1092190110.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Suzuki, Toshihiro, Oyamada Masahito, and Tetsuro Takamatsu. "Different Regulation of Connexin26 and ZO-1 in Cochleas of Developing Rats and of Guinea Pigs with Endolymphatic Hydrops." Journal of Histochemistry & Cytochemistry 49, no. 5 (May 2001): 573–86. http://dx.doi.org/10.1177/002215540104900504.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Kameda, Y. "Immunoelectron microscopic localization of vimentin in sustentacular cells of the carotid body and the adrenal medulla of guinea pigs." Journal of Histochemistry & Cytochemistry 44, no. 12 (December 1996): 1439–49. http://dx.doi.org/10.1177/44.12.8985136.

Full text

Abstract:

The sustentacular cells of the carotid body and the adrenal medulla of guinea pigs were studied by light and electron microscopic immunohistochemistry and compared with the Schwann or satellite cells of the peripheral nervous system. In the peripheral nervous system, neurons were immunoreactive for protein gene product (PGP) 9.5, whereas Schwann cells or satellite cells were immunoreactive for S-100 protein and vimentin. Vimentin immunoreactivity was detected on the intermediate filaments of the Schwann cells by post-embedding immunogold labeling. In the carotid body and the adrenal medulla, glomus cells or chromaffin cells were dosely enveloped by the sustentacular cells, which protruded long cytoplasmic processes and had some axons embedded in them, as in Schwann cells. The glomus cells or chromaffin cells expressed immunoreactivity for PGP 9.5, whereas the sustentacular cells expressed immunoreactivity for S-100 protein and vimentin. The sustentacular cells were characterized by the presence of abundant intermediate filaments on which immunogold particles for vimentin were densely located. From these results, it is concluded that the sustentacular cells closely resemble glial cells of the peripheral nervous system in immunohistochemical, ultrastructural, and also functional properties, and may belong to the glial lineage, originating from the neural crest.

APA, Harvard, Vancouver, ISO, and other styles

26

Oliver, C., and Y. Yuasa. "Distribution of basal lysosomes in exocrine acinar cells." Journal of Histochemistry & Cytochemistry 35, no. 5 (May 1987): 565–70. http://dx.doi.org/10.1177/35.5.3031155.

Full text

Abstract:

We examined the distribution of trimetaphosphatase (TMPase)-positive basal lysosomes in pancreas, parotid, submandibular, sublingual, and exorbital lacrimal glands from rats, rabbits, and guinea pigs. The location of the basal lysosomes was compared to that of the acid phosphatase (AcPase)-positive lysosomes. In all of the tissues examined from rat and rabbit, AcPase activity was localized primarily to the Golgi region. Reaction product was localized in GERL, immature secretory granules, and lysosomes lying adjacent to the Golgi apparatus. TMPase activity was found in basal lysosomes and in occasional elongated lysosomes adjacent to the Golgi apparatus. In guinea pig, the distribution of TMPase activity was identical to that seen in the other two species, but a significant number of lysosomes in the basal region of the cells also contained AcPase activity. These results confirm and extend our previous finding (J Histochem Cytochem 31:1209, 1983) that exocrine acinar cells possess two distinct populations of lysosomes. The lysosomes in the Golgi region contain both AcPase and TMPase activity, whereas those in the basal portion of the cells are reactive predominantly for TMPase. The functional significance of the two populations of lysosomes is not understood at present.

APA, Harvard, Vancouver, ISO, and other styles

27

Albuquerque, Agnes Afrodite Sumarelli, Maria Rossato, José Antonio Apparecido de Oliveira, and Miguel Angelo Hyppolito. "Understanding the anatomy of ears from guinea pigs and rats and its use in basic otologic research." Brazilian Journal of Otorhinolaryngology 75, no. 1 (January 2009): 43–49. http://dx.doi.org/10.1016/s1808-8694(15)30830-2.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Iburg, T. M., J. Arnbjerg, and M. L. Rueløkke. "Gender Differences in the Anatomy of the Perineal Glands in Guinea Pigs and the Effect of Castration." Anatomia, Histologia, Embryologia 42, no. 1 (June 6, 2012): 65–71. http://dx.doi.org/10.1111/j.1439-0264.2012.01166.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Kameda, Y. "Production of monoclonal antibodies against a novel glycoprotein synthesized and secreted by dog thyroid C-cells." Journal of Histochemistry & Cytochemistry 40, no. 4 (April 1992): 541–53. http://dx.doi.org/10.1177/40.4.1552188.

Full text

Abstract:

A monoclonal antibody (MAb) that reacted only with thyroid C-cells was raised against cell suspensions from dog thyroid glands, to examine a glycoprotein secreted by C-cells. After chronically-induced hypercalcemia and administration of an anti-thyroid drug, reaction products for the antibody markedly decreased in C-cells, coinciding with alterations in calcitonin immunoreactivity. The antigen recognized by the MAb appears to be a secretory protein. The MAb reacted with C-cells from a wide variety of mammalian species, including rats, mice, hamsters, cattle, cats, rabbits, and monkeys. Furthermore, tumor cells of human medullary thyroid carcinoma, which is derived from C-cells, were immunoreactive to the MAb. Exceptionally, C-cells from guinea pigs and pigs were not stained with the MAb. No crossreactivity was observed in any of the dog tissues examined. Immunoblot analysis demonstrated that the MAb recognized a single prominent band at a molecular weight of approximately 79,000. The 79 KD band reacted with various digoxigenin-labeled lectins, including GNA, DSA, SNA, and MAA; it is a glycoprotein containing mannose, N-acetylglucosamine, and sialic acid. Dog thyroid C-cells were also densely stained with these lectins. The results indicate that thyroid C-cells synthesize and secrete a specific glycoprotein in addition to peptide hormones.

APA, Harvard, Vancouver, ISO, and other styles

30

Dai, Chun-Fu, and Naoyuki Kanoh. "Cytochemical Localization of Ouabain-sensitive, K+-dependent p-Nitrophenylphosphatase Activity in the Choroid Plexus of Normal and Reserpinized Guinea Pigs." Journal of Histochemistry & Cytochemistry 46, no. 8 (August 1998): 975–76. http://dx.doi.org/10.1177/002215549804600812.

Full text

Abstract:

SUMMARY High doses of reserpine induce depletion of biogenic amines. The K-NPPase activity of choroid plexus was determined after one-shot reserpine administration using cerium-based cytochemistry. In normal untreated animals, reaction product was found on the microvilli of the choroidal epithelium but was almost undetectable 3 and 7 days after reserpinization. At 20 days after reserpinization, however, it was detectable. These findings suggested that reserpine decreased the choroidal Na,K-ATPase activity, and that catecholamines might be essential to maintain normal choroidal Na,K-ATPase activity.

APA, Harvard, Vancouver, ISO, and other styles

31

Ogawa, Kazushige, Masashi Tsuji, Hiroyo Noguchi, Shingo Tsuyama, and Fumihiko Sasaki. "Reversible formation of giant and normal-sized mitochondria in gastric parietal cells of guinea pigs." Anatomical Record 278A, no. 2 (2004): 533–39. http://dx.doi.org/10.1002/ar.a.20024.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Heinrich, Ulf R., Irene Schmidtmann, Regina Meuser, Benjamin P. Ernst, Desiree Wünsch, Svenja Siemer, Alena Gribko, Roland H. Stauber, and Sebastian Strieth. "Early Alterations of Endothelial Nitric Oxide Synthase Expression Patterns in the Guinea Pig Cochlea After Noise Exposure." Journal of Histochemistry & Cytochemistry 67, no. 11 (September 11, 2019): 845–55. http://dx.doi.org/10.1369/0022155419876644.

Full text

Abstract:

Constitutively expressed endothelial nitric oxide synthase (eNOS) is supposed to play a role in noise-induced nitric oxide (NO)-production. It is commonly known that intense noise exposure results in inducible NOS (iNOS) expression and increased NO-production, but knowledge about a contribution of the eNOS isoform is still lacking. Effects of noise exposure on eNOS immunolabeling were determined in male guinea pigs ( n=24). For light microscopic analysis, 11 animals were exposed to 90 dB for 1 hr and 6 animals were used as controls. After exposure, eNOS immunostaining was performed on paraffin sections, and the staining intensities were quantified for 4 cochlear regions. For electron microscopic analysis, 2 animals were exposed for 2 hr to 90 dB and 5 animals were used as controls. The intensity of eNOS immunolabeling was found to be already comprehensively increased 1 hr after noise exposure to 90 dB. At the ultrastructural level, a clear increase in eNOS immunolabeling was found in microtubules-rich areas of cochlear cuticular structures. Hence, our findings indicate that the reticular lamina forming the endolymph–perilymph barrier at the apical side of the organ of Corti is involved in a fast intrinsic otoprotective mechanism of the cochlea.

APA, Harvard, Vancouver, ISO, and other styles

33

Lukas, Julius-Robert, Martin Aigner, Michaela Denk, Harald Heinzl, Martin Burian, and Robert Mayr. "Carbocyanine Postmortem Neuronal Tracing: Influence of Different Parameters on Tracing Distance and Combination with Immunocytochemistry." Journal of Histochemistry & Cytochemistry 46, no. 8 (August 1998): 901–10. http://dx.doi.org/10.1177/002215549804600805.

Full text

Abstract:

SUMMARY Carbocyanines (DiI, DiA, DiO) are able to travel along membranes by diffusion and therefore have been used as postmortem neuronal tracers in aldehyde-fixed tissues. Surprisingly, detailed data on the influence of different parameters on tracing distances are still missing. This study was carried out to optimize tracing procedures and to reveal the validity of the combination of postmortem tracing with immunocytochemistry. Carbocyanine crystals were applied to the cervical spinal cord, sciatic nerves, and brachial plexuses of humans and guinea pigs. Incubation in the dark at 37C for 12-15 weeks proved optimal to achieve longest tracing distances (28.9 ± 2.2 mm) in human and animal tissues. Longer incubation times and incubation temperatures higher than 37C did not result in longer tracing distances. No differences were evident between adult and newborn animals and between central and peripheral nervous system. The diffusion coefficient for DiI was calculated to be 2.5 × 10-7 cm2sec-1. After application of DiI to nerves of guinea pig extraocular muscles, DiI-positive afferent perikarya were observed in the anteromedial part of the trigeminal ganglion. These perikarya were identified by calcitonin gene-related peptide immunoreactivity (CGRP-IR). The percentage of CGRP-IR neurons after tracing was concordant with the percentage of CGRP-IR in trigeminal ganglia exclusively processed for CGRP-IR without previous postmortem tracing. These results demonstrate carbocyanines to be specific tracers for exact neuronal mapping studies.

APA, Harvard, Vancouver, ISO, and other styles

34

Umemoto, Masanori, Tamotsu Harada, Hiroshi Kajikawa, and Keijiro Fukuzawa. "Effects of antibiotic nasal nebulizer treatments on the auditory sensory epithelium in guinea pigs." Medical Electron Microscopy 29, no. 2 (November 1996): 70–75. http://dx.doi.org/10.1007/bf02349042.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Kameda, Y. "Differential distribution of S-100 protein and vimentin in the hypophyseal pars tuberalis of the guinea pig." Journal of Histochemistry & Cytochemistry 44, no. 5 (May 1996): 501–10. http://dx.doi.org/10.1177/44.5.8627006.

Full text

Abstract:

In the hypophyseal pars tuberalis of guinea pigs, I examined immunohistochemical localization and development of vimentin and S-100 protein in comparison with those of the pars distalis. In the pars distalis, almost all folliculostellate cells expressed intense immunoreactivity for vimentin. A subpopulation of vimentin-immunoreactive folliculostellate cells was also immunoreactive for S-100 protein. During fetal development, vimentin-immunoreactive cells appeared at mid-gestation in the pars distalis and became numerous at late stages, whereas only a few S-100 immunoreactive cells were observed even at late stages. In the pars tuberalis, a large number of vimentin-immunoreactive cells were distributed in the cranial region surrounding the median eminence and the dorsocaudal region surrounding the infundibular stalk. These cells, however, were sparse in the ventrocaudal region in continuity with the pars distalis. Conversely, dense distribution of S-100 immunoreactive cells was restricted in the ventrocaudal region. Vimentin-immunoreactive cells were elongated and were mostly distributed as solitary cells, whereas S-100 immunoreactive cells were gathered in large or small cell groups and frequently formed colloid-containing follicles. During fetal development, large cell groups immunoreactive for S-100 protein were detected at late stages in the ventrocaudal region. Therefore, in the pars tuberalis S-100 immunoreactive cells are distinct from the vimentin cells and do not correspond to the folliculostellate cells of the pars distalis.

APA, Harvard, Vancouver, ISO, and other styles

36

Tarn, C. C., and Y. C. Wong. "Morphometric and Stereological Study of the Glandular Epithelium of the Seminal Vesicle of Castrated Guinea Pigs Treated with 17β-Oestradiol Benzoate." Cells Tissues Organs 148, no. 4 (1993): 181–88. http://dx.doi.org/10.1159/000147539.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

STAN, Florin Gheorghe. "Comparative Study of the Liver Anatomy in the Rat, Rabbit, Guinea Pig and Chinchilla." Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Veterinary Medicine 75, no. 1 (May 19, 2018): 33. http://dx.doi.org/10.15835/buasvmcn-vm:002717.

Full text

Abstract:

In liver surgical and histological research, small rodents are the most used experimental models. Although the small animals liver is typically lobulated and its macroscopic appearance do not resemble that of the compact human liver, a high degree of lobulation equivalence, allow the use of small rodents in biomedical research. The macroscopic anatomy of the liver of the rat, rabbit, guinea pig and chinchilla was studied from a comparative standpoint. The topography, lobulation and the connection elements of the liver were examined by detailed in situ observation and explanted liver of forty specimens.The rat liver (Hepar) consists of four distinct lobes of different size: the left lateral lobe - LLL (Lobus hepatis sinister lateralis), the median lobe - ML, the right lobe – RL (Lobus hepatis dexter) and the caudate lobe CL (Lobus caudatus). The largest lobe was the median lobe. The rabbit liver consists of five lobes: left lateral lobe - LLL, left medial lobe - LML (Lobus hepatis sinister medialis), right lobe - RL, quadrate lobe – QL (Lobus quadratus) and caudate lobe - CL. The most developed lobe was the left lateral lobe. The caudate lobe had a very narrow attachment on the hilar region. The guinea pig liver show six lobes: left lateral lobe - LLL, left medial lobe - LML, right lateral lobe – RLL (Lobus hepatis dexter lateralis), right medial lobe – RML (Lobus hepatis dexter medialis), quadrate lobe - QL and caudate lobe - CL. The largest lobe of this specie was the left lateral lobe. In chinchilla liver showed four lobes like in the rat. In the rats the most developed hepatic ligament was the falciform ligament (Lig. Falciforme hepatis) which spans from xyphoid process of the sternum and diaphragm to the liver, beginning at the interlobular fissure. The coronary ligament (Lig. Coronarium hepatis) was well developed in all rats. Interlobular ligaments connect the left lateral lobe with the upper caudate lobe. In rabbits, guinea pigs and chinchillas the connection elements were represented by the falciform ligament, coronary ligament, right (Lig.triangulare dextrum) and left triangular ligaments (Lig. Triangulare sinistrum), hepatorenal ligament (Lig.hepatorenale) and hepatoduodenal ligament (Lig. hepatoduodenale) with varying degrees of development.Based on detailed study of the macroscopic anatomy of rat, rabbit, guinea pig and chinchilla a proper experimental model in liver research, could be assessed. In this regard, the vascular anatomy of the liver in the mentioned species is of a great importance and it is subject of another report.

APA, Harvard, Vancouver, ISO, and other styles

38

Kameda, Yoko. "Ontogeny of immunoreactive calcitonin gene-related peptide in thyroid C cells from dogs, rabbits, and guinea pigs." Anatomical Record 220, no. 1 (January 1988): 76–86. http://dx.doi.org/10.1002/ar.1092200110.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

Mei, Feng, Juan Han, Yue Huang, Zhong-Yong Jiang, Cheng-Jie Xiong, and De-Shan Zhou. "Plasticity of Interstitial Cells of Cajal: A Study in the Small Intestine of Adult Guinea Pigs." Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology 292, no. 7 (July 2009): 985–93. http://dx.doi.org/10.1002/ar.20928.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Ingham, Neil J., Sally K. Thornton, Damian McCrossan, and Deborah J. Withington. "Neurotransmitter Involvement in Development and Maintenance of the Auditory Space Map in the Guinea Pig Superior Colliculus." Journal of Neurophysiology 80, no. 6 (December 1, 1998): 2941–53. http://dx.doi.org/10.1152/jn.1998.80.6.2941.

Full text

Abstract:

Ingham, Neil J., Sally K. Thornton, Damian McCrossan, and Deborah J. Withington. Neurotransmitter involvement in development and maintenance of the auditory space map in the guinea pig superior colliculus. J. Neurophysiol. 80: 2941–2953, 1998. The mammalian superior colliculus (SC) is a complex area of the midbrain in terms of anatomy, physiology, and neurochemistry. The SC bears representations of the major sensory modalites integrated with a motor output system. It is implicated with saccade generation, in behavioral responses to novel sensory stimuli and receives innervation from diverse regions of the brain using many neurotransmitter classes. Ethylene-vinyl acetate copolymer (Elvax-40W polymer) was used here to deliver chronically neurotransmitter receptor antagonists to the SC of the guinea pig to investigate the potential role played by the major neurotransmitter systems in the collicular representation of auditory space. Slices of polymer containing different drugs were implanted onto the SC of guinea pigs before the development of the SC azimuthal auditory space map, at ∼20 days after birth (DAB). A further group of animals was exposed to aminophosphonopentanoic acid (AP5) at ∼250 DAB. Azimuthal spatial tuning properties of deep layer multiunits of anesthetized guinea pigs were examined ∼20 days after implantation of the Elvax polymer. Broadband noise bursts were presented to the animals under anechoic, free-field conditions. Neuronal responses were used to construct polar plots representative of the auditory spatial multiunit receptive fields (MURFs). Animals exposed to control polymer could develop a map of auditory space in the SC comparable with that seen in unimplanted normal animals. Exposure of the SC of young animals to AP5, 6-cyano-7-nitroquinoxaline-2,3-dione, or atropine, resulted in a reduction in the proportion of spatially tuned responses with an increase in the proportion of broadly tuned responses and a degradation in topographic order. Thus N-methyl-d-aspartate (NMDA) and non-NMDA glutamate receptors and muscarinic acetylcholine receptors appear to play vital roles in the development of the SC auditory space map. A group of animals exposed to AP5 beginning at ∼250 DAB produced results very similar to those obtained in the young group exposed to AP5. Thus NMDA glutamate receptors also seem to be involved in the maintenance of the SC representation of auditory space in the adult guinea pig. Exposure of the SC of young guinea pigs to γ-aminobutyric acid (GABA) receptor blocking agents produced some but not total disruption of the spatial tuning of auditory MURFs. Receptive fields were large compared with controls, but a significant degree of topographical organization was maintained. GABA receptors may play a role in the development of fine tuning and sharpening of auditory spatial responses in the SC but not necessarily in the generation of topographical order of the these responses.

APA, Harvard, Vancouver, ISO, and other styles

41

Tam, C. C., and Y. C. Wong. "Thiamine pyrophosphatase activity in secretory cells of the lateral prostate and seminal vesicle of normal and castrated guinea pigs and castrates treated with oestradiol." Histochemical Journal 25, no. 1 (January 1993): 77–85. http://dx.doi.org/10.1007/bf00161047.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Cox, Philip G., and Nathan Jeffery. "Reviewing the Morphology of the Jaw-Closing Musculature in Squirrels, Rats, and Guinea Pigs with Contrast-Enhanced MicroCt." Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology 294, no. 6 (May 23, 2011): spc1. http://dx.doi.org/10.1002/ar.21258.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Vollrath, Lutz. "Inverse behaviour of ?synaptic? ribbon and spherule numbers in the pineal gland of male guinea-pigs exposed to continous illumination." Anatomy and Embryology 173, no. 3 (February 1986): 349–54. http://dx.doi.org/10.1007/bf00318918.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Qian, Y. F., R. Liu, J. H. Dai, M. J. Chen, X. T. Zhou, and R. Y. Chu. "Transfer from blue light or green light to white light partially reverses changes in ocular refraction and anatomy of developing guinea pigs." Journal of Vision 13, no. 11 (September 26, 2013): 16. http://dx.doi.org/10.1167/13.11.16.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

de Almeida-Silva, I., J. A. A. de Oliveira, M. Rossato, F. Fiacadori Salata, and M. A. Hyppolito. "Spontaneous reversibility of damage to outer hair cells after sodium salicylate induced ototoxicity." Journal of Laryngology & Otology 125, no. 8 (April 19, 2011): 786–94. http://dx.doi.org/10.1017/s0022215111000612.

Full text

Abstract:

AbstractBackground:High sodium salicylate doses can cause reversible hearing loss and tinnitus, possibly due to reduced outer hair cell electromotility. Sodium salicylate is known to alter outer hair cell structure and function. This study determined the reversibility and cochlear recovery time after administration of an ototoxic sodium salicylate dose to guinea pigs with normal cochlear function.Study design:Prospective experimental investigation.Methods:All animals received a single 500 mg sodium salicylate dose, but with different durations of action. Function was evaluated before drug administration and immediately before sacrifice. Cochleae were processed and viewed using scanning electron microscopy.Results:Changes in outer hair cell function were observed to be present 2 hours after drug administration, with recovery of normal anatomy beginning after 24 hours. Subsequently, derangement and distortion of cilia reduced, with effects predominantly in row three. At 168 hours, cilia were near-normal but with mild distortions which interfered with normal cochlear physiology.Conclusions:Ciliary changes persisted for up to 168 hours after ototoxic sodium salicylate administration.

APA, Harvard, Vancouver, ISO, and other styles

46

Zabel, M., J. Surdyk, and I. Biela-Jacek. "Immunocytochemical study of the distribution of S-100 protein in the parathyroid gland of rats and guinea pigs." Histochemistry 86, no. 1 (1986): 97–99. http://dx.doi.org/10.1007/bf00492351.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

Basic, Marijana, and André Bleich. "Gnotobiotics: Past, present and future." Laboratory Animals 53, no. 3 (May 17, 2019): 232–43. http://dx.doi.org/10.1177/0023677219836715.

Full text

Abstract:

Gnotobiotics or gnotobiology is a research field exploring organisms with a known microbiological state. In animal research, the development of gnotobiotics started in the late 19th century with the rederivation of germ-free guinea pigs. Cutting-edge achievements were accomplished by scientists in the Laboratories of Bacteriology at the University of Notre Dame (LOBUND). The primary goals of gnotobiotics were not only the development of the equipment required for long-term husbandry but also phenotypic characterization of germ-free animals. The first isolators were designed by Reynolds and Gustafsson as rigid-wall stainless steel autoclave-like chambers, which were subsequently replaced by Trexler’s flexible-film polyvinyl plastic isolators. Flexible-film or semi-rigid isolators are commonly used today. The long-term maintenance of gnotobiotic rodents is performed in positive-pressure isolators. However, to facilitate gnotobiotic experimental procedures, short-term husbandry systems have been developed. Gnotobiotic animal husbandry is laborious and requires experienced staff. Germ-free animals can be rederived from existing rodent colonies by hysterectomy or embryo transfer. The physiology and anatomy of germ-free rodents are different from those of specified pathogen-free (SPF) rodents. Furthermore, to guarantee gnotobiotic status, the colonies need to be regularly microbiologically monitored. Today, gnotobiotics provides a powerful tool to analyse functional effects of host-microbe interactions, especially in complex disease models. Gnotobiotic models combined with ‘omics’ approaches will be indispensable for future advances in microbiome research. Furthermore, these approaches will contribute to the development of novel therapeutic targets. In addition, regional or national gnotobiotic core facilities should be established in the future to support further applications of gnotobiotic models.

APA, Harvard, Vancouver, ISO, and other styles

48

Chole, Richard A., and Kevin Kodama. "Comparative Histology of the Tympanic Membrane and its Relationship to Cholesteatoma." Annals of Otology, Rhinology & Laryngology 98, no. 10 (October 1989): 761–66. http://dx.doi.org/10.1177/000348948909801002.

Full text

Abstract:

The purpose of this study was to determine whether anatomic differences in the tympanic membranes of various species could explain differences in the propensity to form aural cholesteatomas and retraction pockets. Tympanic membranes from humans, dogs, cats, rabbits, guinea pigs, rats, gerbils, and mice were examined histologically. The pars flaccida and pars tensa varied greatly among the species studied. The guinea pig's pars flaccida was very small and had a thin lamina propria. In contrast, the lamina propria of the rabbit and cat pars flaccida were thick. The amount of collagen, elastin, mast cells, and macrophages varied widely. The human and gerbilline tympanic membranes were anatomically dissimilar; for example, the human pars flaccida and pars tensa contained more and denser collagen than did those of the gerbil. The presence of macrophages or mast cells did not correlate with the propensity to develop cholesteatomas. Therefore, anatomic differences among these species do not explain why some develop aural cholesteatomas and others do not.

APA, Harvard, Vancouver, ISO, and other styles

49

Мужикян, А. А., В. В. Шедько, К. О. Заикин, Я. А. Гущин, М. Н. Макарова, and В. Г. Макаров. "COMPARATIVE MORPHOLOGY OF SALIVARY GLANDS OF HUMANS AND LABORATORY ANIMALS." Морфология, no. 1 (March 26, 2020): 79–92. http://dx.doi.org/10.34922/ae.2020.157.1.013.

Full text

Abstract:

В статье обобщены и представлены сравнительные данные о нормальной морфологии околоушной, поднижнечелюстной и подъязычной слюнных желез у человека и некоторых лабораторных животных, наиболее часто попадающих в поле зрения морфологов в сфере биомедицинских исследований. Приведенные в данном обзоре сведения показывают схожесть общих принципов строения и функции больших слюнных желез у человека, крысы, мыши, кролика, морской свинки и хомяка. Однако морфология все же достаточно вариабельна, что объясняется, прежде всего, филогенетическими особенностями, связанными с образом жизни человека и животных, а также характером питания. При этом, если анатомически железы преимущественно однотипны, немного различаясь формой и относительными размерами, то более существенным становятся межвидовые отличия в топографическом расположении желез и их микроскопическом строении. Выявленные в ходе исследования различия в составе секрета той или иной железы у человека и изученных животных были обусловлены, главным образом, особенностями строения ацинусов и выводных протоков, особенностями расположения миоэпителиальных клеток в ацинусах и выводных протоках. Таким образом, при доклинических исследованиях лекарственных средств необходимо учитывать не только физиологические особенности саливации и биохимический состав слюны, но и структурные характеристики слюнных желез у разных видов животных. Представленные в данном обзоре сведения о строении, топографии и синтопии слюнных желез могут быть полезны при выполнении хирургических манипуляций, лечебно-диагностических процедурах и моделировании патологий, а знание особенностей гистологического строения позволит избежать затруднений при постановке диагноза, а также неверной интерпретации данных. The article summarizes comparative data on the normal morphology of the parotid, submandibular, and sublingual salivary glands of humans and some laboratory animals most commonly used in biomedical research. The information presented in this review shows the similarity of the general principles of the structure and function of the large salivary glands of humans, rats, mice, rabbits, guinea pigs and hamsters. However, morphology is still quite variable, which is explained, first of all, by phylogenetic features associated with the lifestyle of humans and animals, as well as the type of nutrition. When the anatomy of the glands is principally the same, only slightly different in shape and relative size, the interspecies differences in the topographic location of the glands and their microscopic structure became more significant. The differences in the composition of the secretion of human glands and glands of studied animals were mainly due to the structural features of the acini and excretory ducts and the location of myoepithelial cells in these structures. Thus, in preclinical studies of drugs, it is necessary to take into account not only the physiological characteristics of salivation and the biochemical composition of saliva but also the structural features of the salivary glands of various animal species. The information on the anatomy, topography, and syntopy of the salivary glands presented in this review can be useful in performing surgical procedures, in diagnostic and treatment procedures, and for modeling pathologies. Information about the histological structure will help to avoid difficulties in making a diagnosis, as well as incorrect interpretation of the data.

APA, Harvard, Vancouver, ISO, and other styles

50

Athanasopoulos, Dimitrios, Axel Heimann, Makoto Nakamura, Irini Kakaletri, Oliver Kempski, and Patra Charalampaki. "Real-Time Overlapping of Indocyanine Green—Video Angiography With White Light Imaging for Vascular Neurosurgery: Technique, Implementation, and Clinical Experience." Operative Neurosurgery 19, no. 4 (April 16, 2020): 453–60. http://dx.doi.org/10.1093/ons/opaa050.

Full text

Abstract:

Abstract BACKGROUND Fluorescent-guided techniques in vascular neurosurgery can be demonstrated via black and white indocyanine green videoangiography (ICG-VA). Multispectral imaging (MFL) is a new method, which overlaps fluorescence with the white light and provides a fluorescent white light augmented reality image to the surgeon. OBJECTIVE To investigate (a) whether MFL can enhance the visualization of the blood-flow with simultaneous visualization of the anatomic structures and (b) if MFL can ergonomically improve the microvascular surgical treatment compared to ICG-VA. METHODS A digital imaging of the blood flow after intravenous injection of ICG on 7 pigs was performed in real time under white light, standard fluorescence, and MFL. The blood flow was interrupted with a surgical clip, demonstrating the blockage of the blood flow. We prospectively included 30 patients with vascular deformities. The vasculature was visualized on the microscope's monitor and through the microscope's eyepiece. RESULTS In the animal experiment, the visualization of the anatomy and the blood flow under MFL produced high resolution images. The occlusion of blood vessels demonstrated sufficiently the blockage of tissue perfusion and its reperfusion after clip removal. During all 30 surgical cases, the MFL technique and the direct delivery of the pseudo-colored image through the eyepiece allowed for enhanced anatomic and dynamic data. CONCLUSION MFL was shown to be superior to the classic ICG-VA, delivering enhanced data and notably improving the workflow due to the simultaneous and precise white light visualization of the blood flow and the surrounding anatomic structures.

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!