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Journal articles on the topic 'Guo hui'

Author: Grafiati

Published: 4 June 2021

Last updated: 31 July 2024

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1

Guo, Hui, Youdi Zhang, Lie Chen, et al. "Correction: Non-halogenated-solvent-processed highly efficient organic solar cells with a record open circuit voltage enabled by noncovalently locked novel polymer donors." Journal of Materials Chemistry A 8, no. 5 (2020): 2851. http://dx.doi.org/10.1039/d0ta90012e.

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Correction for ‘Non-halogenated-solvent-processed highly efficient organic solar cells with a record open circuit voltage enabled by noncovalently locked novel polymer donors’ by Hui Guo et al., J. Mater. Chem. A, 2019, 7, 27394–27402.

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2

Pan, Guo-Hui, Huajun Wu, Shuai He, et al. "Correction: Dye-embedded YAG:Ce3+@SiO2 composite phosphors toward warm wLEDs through radiative energy transfer: preparation, characterization and luminescence properties." Nanoscale 10, no. 48 (2018): 23198. http://dx.doi.org/10.1039/c8nr90266f.

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Correction for ‘Dye-embedded YAG:Ce<sup>3+</sup>@SiO<sub>2</sub> composite phosphors toward warm wLEDs through radiative energy transfer: preparation, characterization and luminescence properties’ by Guo-Hui Pan, Jiahua Zhang et al., Nanoscale, 2018, DOI: 10.1039/c8nr07360k.

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3

Abt, Oded. "Muslim Ancestor, Chinese Hero or Tutelary God." Asian Journal of Social Science 42, no. 6 (2014): 747–76. http://dx.doi.org/10.1163/15685314-04206004.

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This paper examines the dynamic boundaries of Chinese identities and the role of family narratives in their formation. It examines the interplay between history and memory, focusing on traditions regarding ancestors of the Fujian Guo lineage of Muslim descent in China, Taiwan and the Philippines, over six centuries. Existing scholarship approaches these traditions in ethnic terms, corresponding to the ethnic discourse prevalent in the P.R.C., focusing solely on mainland groups, but overlooking other variations found overseas. Hence, scholars portray the changing narratives as reflecting a line

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4

Boo-Chai, Khoo. "Li Guo-hui et al. Investigation and analysis of microbiological flora in blood and wounds in burned patients. (Chinese)." Plastic and Reconstructive Surgery 87, no. 3 (1991): 597. http://dx.doi.org/10.1097/00006534-199103000-00091.

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5

Williams, Richard. "Reviewer Acknowledgements." Journal of Agricultural Studies 3, no. 2 (2015): 274. http://dx.doi.org/10.5296/jas.v3i2.8217.

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Journal of Agricultural Studies would like to thank the following reviewers for reviewing manuscripts from March 1, 2015, to September 1, 2015. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Many authors, regardless of whether JAS publishes their work, appreciate the helpful feedback provided by the reviewers. Macrothink Institute appreciates the following reviewers’ rigorous and conscientious efforts for this journal. Each of the reviewers listed below returned at least one review during this period. Ashit Kumar Paul,Eliana Mariela W

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Zhu, Wenjuan, Wanling Li, Hui Yang, Linying Wang, Jun Guo, and Jinnan Gao. "Abstract P6-05-14: The association of sleep quality with anxiety, depression and social support in breast cancer patients with chemotherapy." Cancer Research 83, no. 5_Supplement (2023): P6–05–14—P6–05–14. http://dx.doi.org/10.1158/1538-7445.sabcs22-p6-05-14.

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Abstract Background:Chemotherapy has side effects on breast cancer patients, and sleep disturbance is one of the common psychological symptoms. Purpose: This study aimed to examine the incidence of sleep disorders and investigate the relationship between anxiety and depression, hope, social support and sleep disorders in breast cancer patients with chemotherapy in China.Results:Total 350 patients were administered questionnaires, and 329 patients completed the questionnaires. The recovery rate was 94%. The majority of participants reported clinically significant sleep disturbance prior to chem

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Casals-Terré, Jasmina. "Ying Sing Fung, Qidan Chen, Fuying Du, Wenpeng Guo, Tongmei Ma, Zhou Nie, Hui Sun, Ruige Wu, Wenfeng Zhao (Eds.): Microfluidic chip-capillary electrophoresis devices." Analytical and Bioanalytical Chemistry 408, no. 8 (2016): 1989–91. http://dx.doi.org/10.1007/s00216-015-9291-0.

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8

Guo, Yongxin, Xinlei Guo, Yisen Wang, Tao Wang, Hui Fu, and Jiazhen Li. "Closure to “Flow condition identification and discharge calibration for submerged radial gates” by YONGXIN GUO, XINLEI GUO, YISEN WANG, TAO WANG, HUI FU and JIAZHEN LI, J. Hydraulic Res. 59(4), 2021, 683–690 https://doi.org.10.1080/00221686.2020.1818305." Journal of Hydraulic Research 60, no. 6 (2022): 1012–13. http://dx.doi.org/10.1080/00221686.2022.2106595.

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9

Mango, Frank D. "“Distinguishing gases derived from oil cracking and kerogen maturation: Insights from laboratory pyrolysis experiments.” Guo Liguo, Xiao Xianming, Tian Hui, Song Zhiguang, 2009, Organic Geochemistry 40, 1074–1084." Organic Geochemistry 41, no. 7 (2010): 719–20. http://dx.doi.org/10.1016/j.orggeochem.2010.02.012.

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10

Hostetler, Laura. "Huang yu sou lan: Meiguo guo hui tu shu guan suo cang ming qing yu tu = Reading Imperial Cartography: Ming Qing Historical Maps in the Library of Congress." Imago Mundi 67, no. 2 (2015): 243–44. http://dx.doi.org/10.1080/03085694.2015.1027572.

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11

Zhao, Hui, Meng Zhang, Zhengcheng Guo, Cong Zhang, Shuliang Li, and Guojin Wu. "Abstract 5300: Therapeutical antibody against TIGIT disrupts inhibitory signaling and restores antitumor immunity." Cancer Research 82, no. 12_Supplement (2022): 5300. http://dx.doi.org/10.1158/1538-7445.am2022-5300.

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Abstract T cell immunoglobulin and ITIM domain (TIGIT) is an inhibitory receptor expressed mainly on T cell and NK cells. And because of its central role in limiting antitumor immune response and few immune-related adverse events with defect TIGIT, it has been an attractive target in cancer immunotherapy recently. Here we describe a humanized antibody against TIGIT by blocking its function and mediating ADCC to deplete TIGIT positive Treg cells. The antibody was derived from hybridoma of mice immunized with TIGIT-mFc. Comparing to TIGIT antibody in clinical (Tiragolumab), this antibody had hig

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12

Shomali, Maysoun, Zhuyan Guo, Jane Cheng, et al. "Abstract P4-02-08: Amcenestrant in combination with CDK4/6 inhibitor palbociclib demonstrates synergistic anti-tumor activity in ER+ endocrine-resistant breast cancer xenograft models." Cancer Research 82, no. 4_Supplement (2022): P4–02–08—P4–02–08. http://dx.doi.org/10.1158/1538-7445.sabcs21-p4-02-08.

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Abstract Nearly 70% of newly diagnosed cases of breast cancer (BC) are estrogen receptor positive (ER+) where endocrine therapy is a primary treatment. Despite initial efficacy seen with endocrine therapies, approximately 40% of patients develop acquired resistance which ultimately limits the use of these agents even as most of these tumors continue to require ERα. The strategies to combat these cancers with resistance are not yet defined and represent the next major clinical challenge in ER+ breast cancer. Amcenestrant is an optimized oral SERD (selective estrogen receptor degrader) with pote

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13

Wang, Long, Yilin Liu, Hui Shi, et al. "Abstract 6273: CTS3157, a novel MTA-cooperative PRMT5 inhibitor for targeting MTAP-deleted human tumors." Cancer Research 83, no. 7_Supplement (2023): 6273. http://dx.doi.org/10.1158/1538-7445.am2023-6273.

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Abstract MTAP deletion is common in about 15% of all human cancers and coincides with the deletion of tumor suppressor locus containing CDKN2A/B. Methylthioadenosine (MTA), the substrate of MTAP, accumulates as a result of MTAP deletion. Increased levels of MTA result in partial inhibition of the PRMT5 enzyme by competing with S-adenosylmethionine (SAM, the methyl donor for PRMT5 substrate) due to structural similarity. Cancer cell lines with MTAP-deletion exhibit profound sensitivity to PRMT5 inhibition, suggesting MTAPnull-selective PRMT5 inhibitors have the potential to treat patients with

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Gao, Zhidong, Jing Zhou, Ying Xin, et al. "Abstract 5873: Distinct prevalence and spectrum of germline cancer susceptibility gene mutations between early-onset and late-onset colorectal caner." Cancer Research 82, no. 12_Supplement (2022): 5873. http://dx.doi.org/10.1158/1538-7445.am2022-5873.

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Abstract Background: In the past few decades, the incidence of early-onset CRC (&lt;50 years of age) has increased globally. Previous studies with small sample sizes have shown that early-onset CRC appears to have a distinct clinical, pathologic, and molecular features compared to late-onset CRC (≥ 50 years of age). However, few studies in a large population have focused on the differences in germline gene mutation spectrums of these two groups of patients. Methods: Hybrid capture-based next-generation sequencing (NGS) were performed in 5080 colorectal patients in a CAP/CLIA-approved labor

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Jia, Haiqun(John), Dorthy Fang, Molly Lobsinger, et al. "Abstract 2908: PT217, an anti-DLL3/anti-CD47 bispecific antibody, exhibits anti-tumor activity through novel mechanisms of action." Cancer Research 82, no. 12_Supplement (2022): 2908. http://dx.doi.org/10.1158/1538-7445.am2022-2908.

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Abstract Small cell lung cancer (SCLC) is the most lethal subtype of lung cancers with few patients surviving more than 5 years from diagnosis. While SCLC initially responds well to standard chemotherapy treatment, chemotherapy-resistant recurrence is characteristic and available treatment options for recurrent and refractory diseases are limited. Immunotherapy as an alternative or additional treatment has been very successful in treating many cancers, yet it has shown disappointingly limited benefits in SCLC and notable treatment related toxicities have been observed. Delta like 3 (DLL3) is a

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Lin, Yanan, Shengbang Zhang, Jie Ran, et al. "Abstract 5135: Standardized off-the-shelf engineered NK cell therapy with improved ADCC properties to treat malignancies." Cancer Research 83, no. 7_Supplement (2023): 5135. http://dx.doi.org/10.1158/1538-7445.am2023-5135.

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Abstract In the treatment of solid tumors, chimeric antigen receptor(CAR)-engineered NK (CAR-NK) cells have distinct advantages over CAR-T cells, such as a lack graft-versus-host disease in allogenic setting to make “off the shelf” medicine; much safer because they are less likely to cause cytokine storms; and NK cells have their own activated receptors that recognize tumor surface antigens and thus have a natural ability to kill a wide range of tumors. In addition, NK cells are the main performers of antibody-dependent cell-mediated cytotoxicity (ADCC), which binds to the Fc-terminus of antib

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Chen, Yunyun, Jiangmei Li, Yanan Guo, et al. "Abstract 1528: 6B5, an anti-human B7-H3 therapeutic antibody that enhances antibody-dependent cellular cytotoxicity and inhibits tumor growth in B7-H3-humanized mice." Cancer Research 83, no. 7_Supplement (2023): 1528. http://dx.doi.org/10.1158/1538-7445.am2023-1528.

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Abstract B7-H3 (CD276) is a type I transmembrane protein belonging to the B7 family of immune-regulatory ligands. Initially reported as a costimulatory signal of human T cells, increasing evidence suggests that it may also have coinhibitory function. TLT-2 has been identified as a potential cognate receptor for B7-H3, but others may exist. Overexpression of B7-H3 protein is found in a variety of human cancers, including lung adenocarcinomas, neuroblastomas, gliomas, and pancreatic tumors—and is associated with poor prognosis and survival. While B7-H3 can promote T cell activation and anti-tumo

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18

Niu, Zhenlan, Xuan Yu, Zhiyuan Shen, Jing Guo, Qingcong Lin, and Hui Xu. "Abstract 5345: Development and validation of humanized HLA mouse model platforms for preclinical evaluation of novel peptide vaccines." Cancer Research 84, no. 6_Supplement (2024): 5345. http://dx.doi.org/10.1158/1538-7445.am2024-5345.

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Abstract The human leukocyte antigen (HLA) class I major histocompatibility complex (MHC) plays an integral role in immune surveillance by presenting intracellular antigen peptides on the cell surface, enabling recognition by cytotoxic T cells and subsequent elimination. Harnessing this intrinsic process for cancer immunotherapy is a promising therapeutic strategy; thus, developing preclinical models to evaluate the efficacy of novel peptide vaccines in vivo and ex vivo is critical. Previously, we developed a humanized MHC I mouse model (B-HLA-A2.1 mice), in which we successfully demonstrated

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19

Xu, Jianming, Haiping Jiang, Yueyin Pan, et al. "Abstract CT078: First-line treatment with sintilimab (sin) vs placebo in combination with chemotherapy (chemo) in patients (pts) with unresectable gastric or gastroesophageal junction (G/GEJ) cancer: Final overall survival (OS) results from the randomized, phase III ORIENT-16 trial." Cancer Research 83, no. 8_Supplement (2023): CT078. http://dx.doi.org/10.1158/1538-7445.am2023-ct078.

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Abstract Background: The phase III ORIENT-16 trial evaluated sin (a PD-1 inhibitor) versus placebo plus chemo as first-line (1L) treatment in pts with advanced G/GEJ adenocarcinoma. Sin+chemo previously showed a significant improvement in OS vs chemo in pts with PD-L1 combined positive score (CPS) ≥5 (HR 0.660; 95% CI 0.505-0.864; P=0.0023) and in all pts (HR 0.766; 95% CI 0.626-0.936; P=0.0090), with a median follow-up of 18.8 months (m) at interim analysis (Xu, et al. Ann Oncol 2021). Here we report the results from the final analysis (NCT03745170). Methods: This double-blind, phase III tria

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Mai, Hai-Qiang, Ya-Qian Han, Guo-Wu Wu, et al. "Abstract CT113: A dose-exploring, randomized, open-label, Phase I study for toripalimab subcutaneous injection in patients with advanced nasopharyngeal carcinoma." Cancer Research 84, no. 7_Supplement (2024): CT113. http://dx.doi.org/10.1158/1538-7445.am2024-ct113.

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Abstract Background Toripalimab, a humanized IgG4K monoclonal antibody specific for PD-1, in combination with gemcitabine and cisplatin (GP) has been approved as a first-line treatment for recurrent or metastatic nasopharyngeal carcinoma (RM-NPC) by the US FDA in October 2023. This is the first-in-human clinical trial (NCT05751486) to investigate the pharmacokinetics of toripalimab subcutaneous (SC) formulation in RM-NPC and determine the appropriate subcutaneous administration regimen for subsequent clinical trials. Methods Patients with histologically confirmed RM-NPC and without previously

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Gao, Feng, Bin Liu, Liandong Jing, et al. "Abstract 1145: PH020-803: an MTA-cooperative and brain-penetrable PRMT5 inhibitor that selectively targets MTAP-deleted tumors." Cancer Research 83, no. 7_Supplement (2023): 1145. http://dx.doi.org/10.1158/1538-7445.am2023-1145.

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Abstract Background: Methylthioadenosine phosphorylase (MTAP) gene deletion occurs in ~10% of human cancers and is enriched in non-small cell lung cancer, pancreatic cancer and brain cancer. Since MTAP is the only enzyme responsible for methylthioadenosine (MTA) degradation, homozygous deletion of MTAP gene leads to intracellular accumulation of MTA. MTA competes with S-adenosylmethionine (SAM, the methyl donor) and results in partial inhibition of protein arginine methyltransferase 5 (PRMT5) activity. Recent studies reported that tumor cells with MTAP loss are vulnerable to PRMT5 inhibition.

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Gao, Feng, Bin Liu, YongYong Wu, et al. "Abstract 4005: PH009-1, a highly potent and selective fourth-generation EGFR-TKI overcoming EGFR common mutations and T790M/C797S-mediated resistance in NSCLC." Cancer Research 83, no. 7_Supplement (2023): 4005. http://dx.doi.org/10.1158/1538-7445.am2023-4005.

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Abstract Background: Epidermal growth factor receptor (EGFR) activating mutations have been reported in 10-50% of patients with non-small cell lung cancer (NSCLC). The common mutations, ex19del (D) and L858R (L) substitution, are sensitive to first- and second-generation EGFR-TKIs. However, acquired on-target resistance, especially T790M (T) mutation, comprises the anti-tumor effects of these inhibitors. Though the third-generation EGFR-TKI Osimertinib potently inhibits both EGFR common mutations and T790M mutation, 10-24% of patients acquire C797S (C) resistant mutation. Here, we report a hig

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Shi, Jing, Jiaqing Yan, Yaling Huang, et al. "Abstract 739: AMT-253, a first-in-class MUC18-targeting antibody-drug conjugate, for the treatment of MUC18-positive solid tumors." Cancer Research 84, no. 6_Supplement (2024): 739. http://dx.doi.org/10.1158/1538-7445.am2024-739.

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Abstract MUC18, also known as MCAM (melanoma cell adhesion molecule) or CD146, is a type I transmembrane glycoprotein originally identified as a cell adhesion molecule of melanoma that plays important roles in tumor growth and progression including tumor angiogenesis, epithelial-mesenchymal transition (EMT), and metastasis. MUC18 is overexpressed in a variety of solid tumors including (but not limited to) melanoma, osteosarcoma, head and neck, lung, esophagus, breast, ovarian, and cervical cancer and hepatocellular carcinoma, with restricted presence on normal healthy tissues, mainly on blood

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Lee, Dong Jun, Sabine Rottmann, Anna Wang, et al. "Abstract 1909: Advancing a novel tubulin-inhibitor ADC technology: The Adcentrx auristatin platform offers enhanced efficacy and safety profiles compared to vedotin technology." Cancer Research 84, no. 6_Supplement (2024): 1909. http://dx.doi.org/10.1158/1538-7445.am2024-1909.

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Abstract Auristatins represent an important class of anti-mitotic antibody-drug conjugate (ADC) payloads with potent cytotoxic effects on rapidly dividing cancer cells. Most notably, monomethyl auristatin E (MMAE) stands as the most extensively validated compound, laying the foundation for the vcMMAE (vedotin) linker-payload technology that has contributed to the approval of several ADCs, including brentuximab vedotin, polatuzumab vedotin-piiq, tisotumab vedotin-tftv, and enfortumab vedotin-ejfv. However, while these first-generation ADCs have paved the way for a paradigm shift in cancer treat

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Li, Wenyuan, and Hui Guo. "Abstract 1538: Impact of C-reactive protein on the efficacy of immune checkpoint inhibitors in non-small cell lung cancer." Cancer Research 84, no. 6_Supplement (2024): 1538. http://dx.doi.org/10.1158/1538-7445.am2024-1538.

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Abstract Background: Immune checkpoint inhibitors (ICIs) therapy has achieved remarkable success in the treatment of non-small cell lung cancer (NSCLC). Clinical studies have suggested a correlation between C-reactive protein (CRP) levels and treatment efficacy, but it remains unclear whether CRP can directly impact the efficacy. Therefore, we investigated the imapct of CRP on the efficacy of ICIs in NSCLC. Methods: The tumor growth model was established in CRP knockout and wildtype mice by injecting LLC cells to evaluate the effect of CRP on tumor proliferation. The frequencies and phenotypes

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Shi, Hui, Meng Wang, Jiaxin Huang, et al. "Abstract 4021: CTS2016, a novel AXL/FLT3 inhibitor for targeting AML/MDS and solid tumors." Cancer Research 83, no. 7_Supplement (2023): 4021. http://dx.doi.org/10.1158/1538-7445.am2023-4021.

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Abstract We identified CTS2016 as a novel, selective, orally bioavailable small molecule inhibitor with single-digit nanomolar enzymatic activity to AXL and FLT3. Overexpression of AXL is associated with metastasis, drug resistance, and poor prognosis of various hematological and solid tumors, which are all broadly modulated with epigenetic regulation. In addition, inhibition of AXL phosphorylation may overcome drug resistance to current FLT3 inhibitors in FLT3-ITD+ Acute Myeloid Leukemia (AML) (Park et al., 2015). We tested CTS2016 as a single agent or in combination with either venetoclax, a

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Xu, Chang, Kie Kyon Huang, Jia Hao Law, et al. "Abstract P28: Comprehensive Molecular Phenotyping of ARID1A-deficient Gastric Cancer Reveals Pervasive Epigenomic Reprogramming and Therapeutic Opportunities." Cancer Research 84, no. 8_Supplement (2024): P28. http://dx.doi.org/10.1158/1538-7445.fcs2023-p28.

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Abstract Objective Gastric cancer (GC) is a leading cause of cancer mortality, with ARID1A being the second most frequently mutated driver gene in GC. We sought to decipher ARID1A-specific GC regulatory networks and examine therapeutic vulnerabilities arising from ARID1A loss. Design Genomic profiling of GC patients including a Singapore cohort (&gt;200 patients) was performed to derive mutational signatures of ARID1A inactivation across molecular subtypes. Single-cell transcriptomic profiles of ARID1A-mutated GCs were analyzed to examine tumor microenvironmental changes arising from ARID1

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Sun, Ao, Mengshi Gao, Rong Guo, et al. "Abstract 2372: ATG-102, a novel LILRB4 x CD3 T cell engager, targeting two nonoverlapping epitopes of LILRB4, for the treatment of monocytic AML." Cancer Research 84, no. 6_Supplement (2024): 2372. http://dx.doi.org/10.1158/1538-7445.am2024-2372.

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Abstract Background: Acute myeloid leukemia (AML) is the most common acute leukemia in adults, and the treatment of AML, especially monocytic AML subtypes still has a poor outcome. T cell engagers (TCE) have been well used for the treatment of hematological malignancies, such as B cell leukemia and multiple myeloma. However, lack of ideal target antigens that only express on AML and leukemic stem cells (LSCs) but not on normal hematopoietic stem cells (HSCs) hampers the development of TCE therapy for AML. Leukocyte immunoglobulin-like receptor B4 (LILRB4), an inhibitory receptor belonging to t

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Cai, Hui, Veronica Wendy Setiawan, Xingyi Guo, et al. "Abstract 468: Associations of circulating miRNAs with pancreatic cancer risk differ by years between blood collection & and cancer diagnosis." Cancer Research 84, no. 6_Supplement (2024): 468. http://dx.doi.org/10.1158/1538-7445.am2024-468.

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Abstract Pancreatic adenocarcinoma (PDAC) is one of the most fatal cancers and currently used biomarkers for PDAC diagnosis are not adequate for early detection. Therefore, new biomarkers for PDAC early detection are urgently needed. We conducted a large-scale study to prospectively evaluate the association of circulating miRNAs with PDAC risk. Specially, we aimed to examine whether the associations of miRNAs expression levels and changes of those levels from blood collection to cancer diagnosis (BCCD) with PDAC risk. We used pre-diagnostic plasma samples of 1307 PDAC cases from 5 cohort studi

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Guo, Yan, Judy Bai, Katherine Ma, et al. "Abstract 3505: Cancer disparities in race exposed through geospatial analysis of mutational signatures and environmental exposure." Cancer Research 83, no. 7_Supplement (2023): 3505. http://dx.doi.org/10.1158/1538-7445.am2023-3505.

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Abstract Background: Cancer has been disproportionally affecting minorities in the US due to socioeconomic, environmental, and genetic disparities. Cancer disparities are usually measured in incidence, mortality, survival, etc. Genomic-based cancer disparity analyses have been less common. In the past decade, mutational signatures were proposed as characteristic footprints of endogenous or exogenous carcinogens, which remarkably propelled the progress of genomic cancer research. The disparities caused by uneven exposure to environmental pollutants may be recorded in mutational signatures. Meth

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Liu, Yilin, Long Wang, Hui Shi, et al. "Abstract 4596: Targeting arginine methylome in 9p21/MTAP-deleted malignant cancers with a next generation PRMT5-specific inhibitor CTS3497." Cancer Research 84, no. 6_Supplement (2024): 4596. http://dx.doi.org/10.1158/1538-7445.am2024-4596.

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Abstract It remains largely challenging to treat cancer patients with chromosome 9p21-deletion which occurs in approximately 15% of human cancers. Recently, specific targeting of protein arginine methyltransferase 5 (PRMT5), a key member of the type-II PRMT family and a master epigenetic modulator of arginine methylome essential for cancer progression, has emerged as a promising therapy in various hematological and solid tumors with MTAP deletion serving as a precision biomarker. To optimize the potential of targeting PRMT5, we developed CTS3497, a potent, brain-penetrable, orally bioavailable

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Hau, Andrew M., Maria Shahmoradgoli, Dong Jun Lee, et al. "Abstract 1891: Preclinical characterization of ADRX-0706: A next-generation anti-Nectin-4 antibody-drug conjugate with improved therapeutic window." Cancer Research 84, no. 6_Supplement (2024): 1891. http://dx.doi.org/10.1158/1538-7445.am2024-1891.

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Abstract Nectin-4 is a well validated tumor target, which is highly expressed in several solid cancers such as urothelial, head-and-neck, breast, lung, pancreatic, ovarian, and cervical cancer, while expression in normal tissues is limited. A first-generation antibody-drug conjugate targeting Nectin-4, called enfortumab vedotin-ejfv (EV), was granted accelerated FDA approval in 2019 for urothelial cancers, and is currently approved for frontline therapy in cisplatin-ineligible patients with locally advanced or metastatic urothelial carcinoma, providing groundbreaking improvement in patient sur

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Wang, Jianwei, Kun Wang, Tianling Qin, et al. "Analysis and prediction of LUCC change in Huang-Huai-Hai river basin." Open Geosciences 12, no. 1 (2020): 1406–20. http://dx.doi.org/10.1515/geo-2020-0112.

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AbstractLand use/cover change plays an important role in human development and environmental health and stability. Markov chain and a future land use simulation model were used to predict future change and simulate the spatial distribution of land use in the Huang-Huai-Hai river basin. The results show that cultivated land and grassland are the main land-use types in the basin, accounting for about 40% and 30%, respectively. The area of cultivated land decreased and artificial surfaces increased from 1980 to 2010. The degree of dynamic change of land use after the 1990s was greater than that b

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Yin, Zheng, and Kim Tae-Man. "≪Hai Guo Tu Zhi≫ and Weiyuan‘s Marine Awareness." Chinese Studies 67 (June 30, 2019): 323–36. http://dx.doi.org/10.14378/kacs.2019.67.67.18.

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Hou, Bing, Hui Xie, Shengyue Piao, Zhi Guo, Bo Shan, and Jay Mei. "Abstract 4032: Identification of Muc5B mutation as a positive predictive biomarker for mTORC1/2 inhibition by ATG-008 in lung cancer." Cancer Research 82, no. 12_Supplement (2022): 4032. http://dx.doi.org/10.1158/1538-7445.am2022-4032.

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Abstract Background: mTOR is a serine/threonine kinase that regulates cell growth, metabolism, proliferation, and survival. mTOR complex-1 (mTORC1) and mTOR complex-2 (mTORC2) are critical mediators of the PI3K-AKT pathway. Signaling by the PI3K/AKT/mTOR pathway is frequently deregulated in solid tumors and hematological malignancies. Inhibition of mTOR by small molecule inhibitors has therefore attracted great attention as an anti-cancer therapy. However, due to relatively modest clinical efficacy, no mTOR inhibitor has been approved for the treatment of lung cancer. The research of potential

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Huang, Yuanyuan, Hangbo Ye, Qingliang Yang, et al. "Abstract 5820: An antibody drug conjugate platform based on novel camptothecin payloads with branch hydrophilic linkers and site-specific conjugation." Cancer Research 84, no. 6_Supplement (2024): 5820. http://dx.doi.org/10.1158/1538-7445.am2024-5820.

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Abstract Antibody-drug conjugates (ADCs) have recently gained momentum as a therapeutic modality for the cell-specific delivery of small molecules beyond their originally-intended purpose of treating cancer. However, the selection of combinations of an optimum target, antibody, payload, linker as well conjugation, to achieve maximal therapeutic efficacy without excessive toxicity, still presents a significant challenge. Topoisomerase I (Topo I) inhibitors such as camptothecin (CPT) analogs represent the much success in ADC payload applications as two CPT analog-ADCs, trastuzumab deruxtecan (DS

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Lee, Ming J. "Dr. Xian-Hua Gao." Clinical Anatomy 7, no. 3 (1994): 167–68. http://dx.doi.org/10.1002/ca.980070311.

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Mao, Lili, Jun Guo, Lingjun Zhu, et al. "Abstract CT519: FCN-159, a MEK1/2 inhibitor, in patients with advanced melanoma harboring NRAS mutations: A phase 1A dose-escalation study." Cancer Research 82, no. 12_Supplement (2022): CT519. http://dx.doi.org/10.1158/1538-7445.am2022-ct519.

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Abstract Purpose: No targeted therapy has been approved for NRAS-mutant melanoma. We evaluated the safety and tolerability and determined the recommended phase 2 dose (RP2D) of FCN-159, a selective MEK1/2 inhibitor, in patients with NRAS-mutant advanced melanoma. Methods: This single-arm, open-label, dose-escalation, phase 1A study in China (NCT03932253) enrolled patients with unresectable stage III/IV melanoma harboring NRAS mutations. Patients received FCN-159 in doses escalating from 0.2 mg until the maximum tolerated dose (MTD). Oral FCN-159 was given once in the single-dose period and onc

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Li, Jun, Chengshan Niu, Zhongwei Guo, et al. "Abstract 4488: TY-4028: a novel, targeted therapy for non small-cell lung cancer with EGFR exon 20 or HER2 exon 20 insertion mutations." Cancer Research 83, no. 7_Supplement (2023): 4488. http://dx.doi.org/10.1158/1538-7445.am2023-4488.

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Abstract Epidermal growth factor receptor (EGFR) activating mutations represent major drivers to the development of non-small cell lung cancer (NSCLC). Among the oncogenic EGFR mutations, a significant cohort, counting for approximately 4-10% of the EGFR mutation spectrum, bear EGFR exon 20ins mutations. Meanwhile, approximately 2% of NSCLC patients bear hotspot mutations in HER2. Strikingly, over 90% of the HER2 mutations occurred in NSCLC are identified as exon 20ins mutations. Despite the successful launch of 1st, 2nd, and 3rd generation of EGFR inhibitory agents in the clinic that inactiva

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Qin, Shukui, Xiaoyan Lin, Zhiqaing Meng, et al. "Abstract CT150: Result of an open-label phase 2 trial of dual TORC1/TORC2 inhibitor onatasertib (ATG-008) in HBV+ advanced hepatocellular carcinoma (HCC) subjects who have received at least one prior line of systemic therapy (TORCH)." Cancer Research 83, no. 8_Supplement (2023): CT150. http://dx.doi.org/10.1158/1538-7445.am2023-ct150.

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Abstract Background: The mammalian target of rapamycin (mTOR) is a serine/threonine kinase related to the lipid kinases of the phosphoinositide 3-kinase (PI3K) family, which has been confirmed to be closely related to the development of a variety of human cancers. Onatasertib (ATG-008) is a 2nd generation mTOR inhibitor which inactivates both mTORC1 and mTORC2. Our previous clinical investigation (NCT01177397) has demonstrated preliminary evidence of antitumor activity of onatasertib across multiple solid and hematologic malignancies, with encouraging signals of activity in subjects with hepat

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Xu, Shuai, Yaohua Yang, Tianying Zhao, et al. "Abstract LB146: Multi Omics analyses identified novel loci and genes for lung cancer risk among European Descendants." Cancer Research 84, no. 7_Supplement (2024): LB146. http://dx.doi.org/10.1158/1538-7445.am2024-lb146.

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Abstract Introduction Genome-wide association studies (GWAS) have identified &gt;60 genomic loci for lung cancer risk. However, causal genes and the underlying biological mechanisms for most of these loci remain unknown. Therefore, we conducted a multi-omics study to identify lung cancer susceptibility genes. Method We first conducted a transcriptome-wide association study (TWAS) using S-PrediXcan framework. Whole transcriptome data from adjacent-normal lung tissue samples and genomic data from 304 European-ancestry lung cancer patients were used to build genetic prediction models for expr

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ZAGORODNYUK, Pavlo, and Andriy ZAGORODNYUK. "FROM NADRA GROUP TO GEO HUB." Ukrainian Geologist, no. 1-2(44-45) (June 30, 2021): 6–33. http://dx.doi.org/10.53087/ug.2021.1-2(44-45).238797.

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NADRA Group was founded in 1991 by Ukrainian geologists. Over time, NADRA Group has transformed into an international group of affiliated service companies that provided high-tech services to production companies. NADRA Group has employed more than one and a half thousand employees, and then the International Hub for natural resources was established on its basis, which brought together hundreds of partner companies, which led to the transition from linear to network business and signifi cantly expanded the activities. Subsequently, the activity of NADRA Group has spread to all natural capital

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Sato, M. "Bei Yi-hui de Ge-ming Qing-jie--Zai Zhong-ri Liang-guo Cong-shi Ge-ming de Li-cheng (Kita Ikki's Radical Complex: The Course of His Involvement in Chinese and Japanese Revolutions), by Huang Tzu-chin. Taipei: Academia Sinica, 2001, 350 pp., NT$350 (hardcover ISBN 957-671-755-8), 341 pp., NT$300 (paperback ISBN 957-671-756-6)." Social Science Japan Journal 8, no. 1 (2004): 131–33. http://dx.doi.org/10.1093/ssjj/jyh046.

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Aradpour, Saber, Roohollah Noori, Qiuhong Tang, et al. "Metal contamination assessment in water column and surface sediments of a warm monomictic man-made lake: Sabalan Dam Reservoir, Iran." Hydrology Research 51, no. 4 (2020): 799–814. http://dx.doi.org/10.2166/nh.2020.160.

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Abstract In this study, metal concentrations in the water column and surface sediment of the Sabalan Dam Reservoir (SDR) were determined. Moreover, heavy metal pollution index (HPI), contamination index (CI), heavy metal evaluation index (HEI), enrichment factor (EF), geo-accumulation index (Igeo), sediment quality guidelines (SQGs), consensus-based SQGs (C-BSQGs), and mean probable effect concentration quotients (mPECQs) were evaluated for water and sediments of SDR. It was observed that metal concentrations in river entry sediment were lower, but those in river entry water were higher than c

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Wang, Haihui, Fika Tri Anggraini, Xuequn Chen, and Donald J. DeGracia. "Embryonic lethal abnormal vision proteins and adenine and uridine-rich element mRNAs after global cerebral ischemia and reperfusion in the rat." Journal of Cerebral Blood Flow & Metabolism 37, no. 4 (2016): 1494–507. http://dx.doi.org/10.1177/0271678x16657572.

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Prolonged translation arrest correlates with delayed neuronal death of hippocampal CA1 neurons following global cerebral ischemia and reperfusion. Many previous studies investigated ribosome molecular biology, but mRNA regulatory mechanisms after brain ischemia have been less studied. Here we investigated the embryonic lethal abnormal vision/Hu isoforms HuR, HuB, HuC, and HuD, as well as expression of mRNAs containing adenine and rich uridine elements following global ischemia in rat brain. Proteomics of embryonic lethal abnormal vision immunoprecipitations or polysomes isolated from rat hippo

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Minglu, Gao, Madeline Eschenburg, Ellen Larson та Dong Li Hui. "The Round Table 02 圆桌: A Conversation with the No Name Painting Group". Contemporaneity: Historical Presence in Visual Culture 4 (3 серпня 2015): 177–89. http://dx.doi.org/10.5195/contemp.2015.155.

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The following is a transcript of a conversation between three members of the No Name Painting Group, as well as Gao Minglu, Madeline Eschenburg, Ellen Larson, and Dong Li Hui. This interview was originally conducted in Chinese and has been edited for clarity.

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Metri, Vishal, Sandhya Rai, and Nicholas J. Laycock. "An Electrocrystallization Approach for Modeling Protective Scale Formation in CO₂ Corrosion of Carbon Steel." ECS Meeting Abstracts MA2023-02, no. 11 (2023): 1069. http://dx.doi.org/10.1149/ma2023-02111069mtgabs.

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The CO2 corrosion of carbon steel has been extensively studied and many models have been developed to estimate the corrosion rate in various industrially relevant conditions [1]. These models agree moderately well in non-scaling environments but can produce significantly different results under higher temperature and higher pH conditions where protective scales of iron carbonate may be formed [2,3]. The scaling effect is typically incorporated in empirical models using a ‘scaling factor’ [2,3]. Nesic and co-workers developed a model that attempts to calculate the corrosion rate in scaled condi

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Mohammed Hameed, Hasan. "SOIL EROSION ASSESSMENT WITHIN THE ERBIL WATERSHED USING GEO-INFORMATICS TECHNOLOGY." Halabja University Journal 6, no. 1 (2016): 311–29. http://dx.doi.org/10.32410/huj-10375.

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Li, Nanxi, Peng Ren, Jingya Wang, et al. "Immune-Related Molecules CD3G and FERMT3: Novel Biomarkers Associated with Sepsis." International Journal of Molecular Sciences 25, no. 2 (2024): 749. http://dx.doi.org/10.3390/ijms25020749.

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Sepsis ranks among the most common health problems worldwide, characterized by organ dysfunction resulting from infection. Excessive inflammatory responses, cytokine storms, and immune-induced microthrombosis are pivotal factors influencing the progression of sepsis. Our objective was to identify novel immune-related hub genes for sepsis through bioinformatic analysis, subsequently validating their specificity and potential as diagnostic and prognostic biomarkers in an animal experiment involving a sepsis mice model. Gene expression profiles of healthy controls and patients with sepsis were ob

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Mishraki-Berkowitz, T., P. Ben Ishai, A. Aserin, Yu Feldman, and N. Garti. "The dielectric study of insulin-loaded reverse hexagonal (HII) liquid crystals." Physical Chemistry Chemical Physics 17, no. 14 (2015): 9499–508. http://dx.doi.org/10.1039/c4cp03162h.

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This paper discusses the structural, dynamic, and kinetic aspects of the insulin-loaded H<sub>II</sub> mesophase (containing GMO–TAG–water–glycerol–insulin) and the two empty reference systems (GMO–TAG–water and GMO–TAG–water–glycerol). Schematic representation of an insulin-loaded water–glycerol-filled H<sub>II</sub> cylinder, at 290 K.

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