Log in

Relevant bibliographies by topics / Gut micobiota and immunity / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Gut micobiota and immunity.

Dissertations / Theses on the topic 'Gut micobiota and immunity'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 42 dissertations / theses for your research on the topic 'Gut micobiota and immunity.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Glymenaki, Maria. "The role of gut flora in epithelial barrier function and immunity." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-gut-flora-in-epithelial-barrier-function-and-immunity(6cb0ca1e-06ff-4cd4-a0a1-76ace6af2a55).html.

Full text

Abstract:

Inflammatory bowel disease (IBD) is associated with an inappropriate immune response to the gut microbiota and disruption of intestinal homeostasis. IBD patients and experimental animal models have consistently shown alterations in the gut microbiota composition. However, these studies have mainly focused on faecal microbiota samples taken after the onset of inflammation and IBD establishment. The colonic microbiota inhabits both the gut lumen and the mucus layer covering the intestinal epithelium. Thus, information about mucus-resident microbiota is not necessarily conveyed in the routine mic

APA, Harvard, Vancouver, ISO, and other styles

2

Li, Yan. "The Interplay Between Diet, the Gut and Immunity in Kidney Disease." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/29257.

Full text

Abstract:

Diabetic Nephropathy (DN), acute kidney injury (AKI) and their associated complications remain a major and under-recognized global health burden. Current therapeutic strategies lack the capacity to prevent or treat AKI and maladaptive repair that leads to progression to chronic kidney disease (CKD). As the predominant cause of CKD and end-stage kidney disease (ESKD) worldwide, strategies to ameliorate progression of DN are similarly inadequate. The aim of this thesis was to explore novel therapeutic strategies to address the burden posed by AKI and DN through targeting innate immunity. This th

APA, Harvard, Vancouver, ISO, and other styles

3

Dahele, Anna V. M. "Systemic and gut mucosal immunity to tissue transglutaminase in coeliac disease." Thesis, University of Edinburgh, 2003. http://hdl.handle.net/1842/23318.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Philipson, Casandra Washington. "Systems analysis and characterization of mucosal immunity." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/74392.

Full text

Abstract:

During acute and chronic infectious diseases hosts develop complex immune responses to cope with bacterial persistence. Depending on a variety of host and microbe factors, outcomes range from peaceful co-existence to detrimental disease. Mechanisms underlying immunity to bacterial stimuli span several spatiotemporal magnitudes and the summation of these hierarchical interactions plays a decisive role in pathogenic versus tolerogenic fate for the host. This dissertation integrates diverse data from immunoinformatics analyses, experimental validation and mathematical modeling to investigate a se

APA, Harvard, Vancouver, ISO, and other styles

5

Lowe, Patrick P. "Inebriated Immunity: Alcohol Affects Innate Immune Signaling in the Gut-Liver-Brain Axis." eScholarship@UMMS, 2018. https://escholarship.umassmed.edu/gsbs_diss/987.

Full text

Abstract:

Alcohol is a commonly consumed beverage, a drug of abuse and an important molecule affecting nearly every organ-system in the body. This project seeks to investigate the interplay between alcohol’s effects on critical organ-systems making up gut-liver-brain axis. Alcohol initially interacts with the gastrointestinal tract. Our research describes the alterations seen in intestinal microbiota following alcohol consumption in an acute-on-chronic model of alcoholic hepatitis and indicates that reducing intestinal bacteria using antibiotics protects from alcohol-induced intestinal cytokine expressi

APA, Harvard, Vancouver, ISO, and other styles

6

Wang, Xin. "INTESTINAL IMMUNITY AND GUT MICROBIOTA IN ALDO-KETO REDUCTASE 1 B8 DEFICIENT MICE." OpenSIUC, 2019. https://opensiuc.lib.siu.edu/dissertations/1723.

Full text

Abstract:

Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second leading cause of cancer death in the United States. Aldo-keto reductase 1 B10 (AKR1B10) is highly expressed in colon and small intestine of normal humans, but its expression is lost or markedly down-regulated in tissues of patients with ulcerative colitis (UC) and CRC. AKR1B10 is a monomeric cytosolic enzyme with strong enzymatic activity to α, β-unsaturated carbonyl compounds, protecting cells from carbonyl lesions; AKR1B10 also mediates de novo synthesis of long chain fatty acids and membrane lipids, such as p

APA, Harvard, Vancouver, ISO, and other styles

7

Doggett, Teresa Ann. "The structure and function of peripheral blood leucocytes and gut-associated lymphoid tissue in the cichlid, Oreochromis mossambicus." Thesis, University of Plymouth, 1989. http://hdl.handle.net/10026.1/2776.

Full text

Abstract:

The peripheral blood of O.mossambicus was examined using light and electron microscopy and was found to contain four forms of leucocytes: lymphocytes, thrombocytes, monocytes and three types of granulocytes. The monocyte and two types of granulocyte were found to be phagocytic and ingest colloidal carbon and bacteria. The alimentary tract was found to contain a number of leucocytes, some showing a morphological similarity to those in the peripheral blood, while others were unique to the gut tissue. These intestinal leucocytes were found mainly as a diffuse cell population in the epithelium and

APA, Harvard, Vancouver, ISO, and other styles

8

Cheramie, Martin N. "Investigations into Mycobacterium marinum Interacting and Crossing Fish Gut Epithelia| Evidence for Inducing a Protective Gut Mucosal Immunity by a Live Vaccine Candidate." Thesis, University of Louisiana at Lafayette, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=1585851.

Full text

Abstract:

<p> <i>Mycobacterium marinum</i> is an established surrogate pathogen for <i>Mycobacterium tuberculosis</i> because of <i>M. marinum </i>'s strong conservation of thousands of orthologous genes, lower risk, lower financial burden to researchers, and similar pathology in fish. This pathogen causes TB-like chronic disease in a wide variety of fish species and can mount superficial infection of human tissues. As in human TB, the microbe grows within the host macrophages, can mount life-long chronic infections, and produces granulomatous lesions in target organs. One of the fish species known to m

APA, Harvard, Vancouver, ISO, and other styles

9

Eisa, Osama Eltayeb Idris. "Modulators of innate gut immunity to enteric viral infections : murine norovirus (MNV) as a model." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/271239.

Full text

Abstract:

Challenged by a huge and diverse antigenic stimulus, the intestinal mucosa has developed a unique immune system that mainly functions to maintain tolerance to innocuous antigens while retaining the ability to respond swiftly to pathogenic threats. Central to this specialised immune system are the Intraepithelial Lymphocytes (IELs). These cells are uniquely located between Intestinal Epithelial Cells (IECs) ready to respond to exogenous antigens in the intestinal lumen. The intestinal immune system is constantly influenced, not only by the commensal microbiota, but also by the nutritional statu

APA, Harvard, Vancouver, ISO, and other styles

10

Nyangahu, Donald D. "Alterations in preconception, antenatal, and postnatal maternal gut microbiota influence offspring intestinal microbiota and immunity." Doctoral thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/25479.

Full text

Abstract:

Maternal microbiota during pregnancy, as well as maternal disease state, may impact offspring gut bacterial colonisation. Here, we explore the impact of maternal antibiotics during gestation and/or nursing on offspring gut microbiota. Further, we investigate the effect of preconception helminth infections on maternal and infant gut microbiota. For maternal antibiotic experiments, dams were fed vancomycin, polymyxin B, or both, in drinking water during gestation, nursing or gestation plus nursing, and their offspring microbiota analysed at 14 days of life, alongside immunity in the spleens. Off

APA, Harvard, Vancouver, ISO, and other styles

11

Lundqvist, Carina. "Human intraepithelial lymphocytes a comparative study of phenotype, morphology, and functional properties of intraepithelial lymphocytes in gut and oral mucosa /." Umeå, Sweden : Dept. of Immunology, Umeå University, 1995. http://books.google.com/books?id=TKppAAAAMAAJ.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Stagaman, Keaton. "Investigating the Role of Immunity and Other Selective Pressures on the Assembly of the Gut Microbiota in Zebrafish and Humans." Thesis, University of Oregon, 2016. http://hdl.handle.net/1794/20455.

Full text

Abstract:

Over the past few decades, it has become increasingly apparent that host-associated microbial communities play an integral role in the development, physiology, and health of their host organisms. All hosts have evolved mechanisms to filter the microbial taxa that comprise their resident intestinal microbial community, or gut microbiota. Utilizing the zebrafish as a model host organism, we documented the development of the gut microbiota through time, and found a significant shift in the composition of the gut microbiota after the onset of adaptive immunity. This led us to hypothesize that

APA, Harvard, Vancouver, ISO, and other styles

13

Maryam, Akramisomeabozorg. "Circulation of gut pre-activated naïve CD8+ T cells enhances anti-tumor immunity in B cell defective mice." Kyoto University, 2020. http://hdl.handle.net/2433/259729.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Echeverry, Andrea. "Innate and Adaptive Immunity in Murine Neonates Infected with the Intestinal Pathogen Yersinia enterocolitica." Scholarly Repository, 2009. http://scholarlyrepository.miami.edu/oa_dissertations/480.

Full text

Abstract:

Neonates are generally thought to be more likely to suffer from gastrointestinal disease, owing in part to diminished immune cell function. To gain insight into the development of mucosal immune responses during early life, we developed a model of orogastric infection with the Gram-negative bacterium Yersinia enterocolitica using murine neonates. Remarkably, neonatal mice of either the BALB/c or C57BL/6 mouse strains showed markedly enhanced survival after infection compared to adult mice. Both innate and adaptive immune components appear to contribute to this phenomenon. First, the incre

APA, Harvard, Vancouver, ISO, and other styles

15

West, Christina. "Feeding Lactobacillus paracasei ssp. paracasei strain F19 to infants during weaning : effects on adaptive immunity and gut microbial function." Doctoral thesis, Umeå universitet, Pediatrik, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1673.

Full text

Abstract:

Introduction: Gut microbial composition has been associated with immune-mediated diseases. Breastfeeding yields a microbiota rich in bifidobacteria and promotes colonization by lactobacilli. Bifidobacteria and lactobacilli are considered health-promoting and are used as probiotics, i.e. live microbial food supplements which when ingested in adequate amounts confer a beneficial effect on the host. During weaning the developing gut immune system is exposed to an increasing variety of antigens from both foods and gut microbiota. Aims: We aimed to determine if daily feeding of 1x108 colony-forming

APA, Harvard, Vancouver, ISO, and other styles

16

Langel, Stephanie Mary Neal. "Defining the Gut-Mammary Gland-Secretory IgA Axis in Porcine Epidemic Diarrhea Virus Infected Gilts and its Impact on Lactogenic Immune Protection of Neonatal Suckling Piglets." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1542041868304033.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Bingula, Rea. "Non-small cell lung cancer, immunity and microbiota : laying ground for the gut-lung-lung cancer axis in human subjects." Thesis, Université Clermont Auvergne‎ (2017-2020), 2019. http://www.theses.fr/2019CLFAS009.

Full text

Abstract:

Le cancer du poumon est la principale cause de décès par cancer dans le monde. En dépit de la variété de traitements disponibles, tels que la chirurgie, la chimiothérapie, la radiothérapie et l’immunothérapie, la survie moyenne à 5 ans est de 60 %. L’une des raisons sous-jacente est une très grande variabilité de réponse au traitement, expliquée par les antécédents génétiques du patient et depuis peu par son microbiote. Le terme « microbiote » regroupe les bactéries, les archées, les champignons, les virus et les protistes qui colonisent notre organisme. Des études utilisant des modèles animau

APA, Harvard, Vancouver, ISO, and other styles

18

Marsilio, Ilaria. "Functional and Molecular Studies of the Crosstalk between Intestinal Microbioma and Enteric Nervous System and Potential Effects on the Gut-Brain Axis." Doctoral thesis, Università degli studi di Padova, 2019. http://hdl.handle.net/11577/3427312.

Full text

Abstract:

L'interazione fra costituenti della parete intestinale e microflora commensale costituisce il principale artefice del mantenimento della barriera mucosale, della promozione dello sviluppo del tratto gastrointestinale (GI) e della modulazione delle funzioni GI. In questo contesto, giocano un ruolo chiave i recettori Toll-like (TLRs), un sistema di proteine che attivano la risposta immunitaria innata e assicurano l'integrità funzionale e strutturale del SNE. In questo studio sono state caratterizzate le alterazioni strutturali e funzionali del SNE murino indotte da: i) cambiamenti nel segnale de

APA, Harvard, Vancouver, ISO, and other styles

19

Roy, Urmi Verfasser], and Dietmar Helmut [Akademischer Betreuer] [Pieper. "The influence of the gut microbiota on host mucosal immunity and its impact on gastrointestinal inflammation / Urmi Roy ; Betreuer: Dietmar Helmut Pieper." Braunschweig : Technische Universität Braunschweig, 2018. http://d-nb.info/1175814954/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Liberti, Assunta. "Ciona gut immunity. Dynamics of variable region-containing chitin-inding proteins (VCBP) distribution in the digestive tract from metamorphosis to the adult." Thesis, Open University, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607483.

Full text

Abstract:

The study of the immune processes that occur in the digestive tract of animals and ensure gut-homeostasis has increased considerably. This topic is of current medical importance in relation to human gut diseases linked to the alteration of gut-microbiota. Variable region-containing Chitin-Binding Proteins (VCBPs), identified originally in the cephalochordate Branchiostoma floridae, are characterized by two V -type immunoglobulin domains and a chitin binding domain. This character could reflect an important transition between non-rearranging immune molecules and conventional rearranging antigen

APA, Harvard, Vancouver, ISO, and other styles

21

Jeyam, geb Sanmuganantham Tharmila [Verfasser]. "Employing disease-associated genetic variants to study the influence of TLR5 and NLRP6 on gut immunity in humans / Tharmila Jeyam geb. Sanmuganantham." Tübingen : Universitätsbibliothek Tübingen, 2023. http://d-nb.info/1237684587/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Abou, Samra Elias. "Elucidation of the Role of NKR‐P1: CLR Recognition Systems in Intestinal & Renal Epithelial Cell Homeostasis and Immunity." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/35747.

Full text

Abstract:

Natural killer (NK) cells represent a crucial component of the innate immune system and are primarily regulated by the interactions of their activation and inhibitory receptors with ligands available on target cells. The genetically linked Ly49 and NKR-P1 family of receptors constitute two of the major regulatory receptor systems used by NK cells and have been shown to bind different ligands. Whereas the Ly49 receptors survey MHC-I ligands on target cells, the NKR-Pl receptor family members bind to various members of the C-type lectin-related (Clr) family. Interestingly, NKR-P1 and Clr haploty

APA, Harvard, Vancouver, ISO, and other styles

23

Silva, Nuno Emanuel de Oliveira Figueiredo da. "Nutrição do intestino, imunidade intestinal e resistência a parasitas do intestino em cães." Bachelor's thesis, Universidade Técnica de Lisboa. Faculdade de Medicina Veterinária, 2009. http://hdl.handle.net/10400.5/1639.

Full text

Abstract:

Dissertação de Mestrado Integrado em Medicina Veterinária<br>A presente dissertação é o resultado do estágio realizado na Faculdade de Ciências Agrárias e Veterinárias da Universidade Estadual Paulista “Júlio de Mesquita Filho”, Campus de Jaboticabal, São Paulo, Brasil. É composta por uma descrição resumida das actividades desenvolvidas durante o estágio, exposição breve da casuística acompanhada, seguida de uma revisão bibliográfica do tema proposto. Esta revisão incide sobre as funções do intestino na nutrição do animal e destaca o papel essencial da dieta na nutrição do intestino. Est

APA, Harvard, Vancouver, ISO, and other styles

24

Moraes, Priscila de Oliveira. "Efeito da mistura do líquido da casca da castanha de caju e do óleo de mamona no desempenho, na imunidade e na microbiota de frangos de corte desafiados por coccidiose." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/169964.

Full text

Abstract:

O objetivo deste estudo foi avaliar o efeito da mistura comercial do líquido da casca de castanha de caju e do óleo de mamona (Essential, Oligo Basics Agroind. Ltda., Cascavel, Brasil) no desempenho, na microbiota e no sistema imune de frangos de corte desafiados ou não por coccidiose. Ao total 864 pintos machos (Cobb) de um dia de idade foram distribuídos aleatoriamente em 6 tratamentos (8 boxes/tratamento e 18 pintos/box) em um desenho fatorial 3 x 2 com 3 aditivos: controle (sem aditivo), 100 ppm de monensina ou 0,15% de Essential e 2 níveis de desafio aos 14 dias de idade: não desafiados o

APA, Harvard, Vancouver, ISO, and other styles

25

PICCININI, SIMONA. "Involvement of Gut Immune System in the pathogenesis of type 1 diabetes: detection of T cell reactivity to Gliadin." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2008. http://hdl.handle.net/2108/558.

Full text

Abstract:

Diversi studi sperimentali hanno evidenziato un possibile ruolo del sistema immune intestinale nella patogenesi del diabete di tipo 1(T1D). Lo scopo del nostro studio è stato quello di evidenziare un possibile link tra il sistema immune intestinale e il T1D, in particolare un possibile ruolo del glutine come antigene T cellulare nel T1D. Le cellule mononucleate del sangue periferico (PBMC) sono state isolate da 25 bambini con T1D (età da 3.4 a 19.6 anni), da 22 controlli sani (HC) (età da 3.5 a 17 anni) entrambi negativi per gli anticorpi antiendomisio e anti-transglutaminasi e da 15 bambini

APA, Harvard, Vancouver, ISO, and other styles

26

Basilissi, M. "T-CELL HOMEOSTASIS, MODIFICATIONS OF MUCOSAL IMMUNITY POPULATIONS AND ASSOCIATION WITH HIV-MEDIATE MICROBIAL TRANSLOCATION AND DYSBYOSIS: EXTENSIVE IMMUNE PHENOTYPING DURING 1 YEAR OF SUCCESSFUL COMBINATION ANTIRETROVIRAL THERAPY (CART)." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/489804.

Full text

Abstract:

In the era of combination antiretroviral therapy (cART), a reduction of HIV and AIDS-comorbidities and death has been described. Nonetheless, immune defects persist during treatment and may be linked to increased morbidity and mortality of HIV-infected subjects compared to the general population. Microbial translocation and dysbiosis as well as impaired mucosal immunity likely represent underlying pathogenic mechanisms of the peripheral immune flaws observed during therapy. However, a systematic investigation of these parameters in a longitudinal cohort of HIV-infected individuals starting

APA, Harvard, Vancouver, ISO, and other styles

27

Silva, Claudia Cassimira da. "Efeito das fontes de zinco na dieta de matrizes suínas e na sua progênie." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/74/74131/tde-28012015-143551/.

Full text

Abstract:

Diante da importância do zinco no desempenho produtivo e reprodutivo de matrizes suínas, e no desempenho de leitões, foram conduzidos três experimentos com o objetivo de avaliar diferentes fontes de zinco na alimentação de suínos. O experimento I avaliou diferentes fontes de zinco, orgânico (zinco+metionina ((Zn-Met) e zinco+glicina(Zn-Gli)) e inorgânico (óxido de zinco(ZnO)) na dieta de matrizes em gestação e lactação e os efeitos do uso destas fontes na sua progênie. Foram utilizadas 18 fêmeas de uma linhagem comercial distribuídas em delineamento experimental de blocos ao acaso, com três tr

APA, Harvard, Vancouver, ISO, and other styles

28

Rahabi, Mouna. "Les macrophages dans l'inflammation colique, approches expérimentale et translationnelle : impact des récepteurs Dectine-1 et mannose et des peptides Naticol(r)Gut." Thesis, Toulouse 3, 2020. http://www.theses.fr/2020TOU30104.

Full text

Abstract:

La maladie de Crohn (MC) et la rectocolite hémorragique (RCH) sont les deux formes principales des maladies inflammatoires chroniques de l'intestin (MICI) et sont le résultat de réactions inflammatoires excessives au niveau du système digestif. Bien qu'elles partagent certaines caractéristiques, ces deux entités se distinguent par des différences concernant la prédisposition génétique, les facteurs de risque, et les caractéristiques cliniques, endoscopiques et histologiques. Dans un premier temps, nous nous sommes intéressés au rôle des récepteurs lectines de type C dans l'inflammation colique

APA, Harvard, Vancouver, ISO, and other styles

29

Pietz, Grzegorz. "Innate immunity of human intestinal epithelium in childhood celiac disease : influences from celiac disease associated bacteria and dietary oats." Doctoral thesis, Umeå universitet, Institutionen för molekylärbiologi (Medicinska fakulteten), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-140691.

Full text

Abstract:

Background & Aims: Celiac disease (CD) is a chronic inflammatory small-bowel enteropathy caused by permanent intolerance to gliadin in wheat gluten, and related proteins in ray and barley. It is disputed whether CD patients tolerate oats. The only treatment of CD is lifelong gluten-free diet (GFD). Only individuals that carry the HLA-DQ2 and/or DQ8 alleles, and eat gluten can develop CD. Dysbiosis in the gut microbiota is a suggested risk factor for CD. T cells in small intestinal mucosa, including intraepithelial lymphocytes (IELs), are known to be important in the pathogenesis of CD. In

APA, Harvard, Vancouver, ISO, and other styles

30

Aristimunha, Patrícia Cruz. "Efeito de diferentes programas de suplementação de um produto à base de ácidos orgânicos e substância húmica na performance, resposta imune e morfometria intestinal de frangos de corte." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/163532.

Full text

Abstract:

As limitações ao uso de antibióticos promotores de crescimento vêm aumentando a procura por aditivos substitutos para manter a performance animal, a saúde intestinal e a resposta imune de frangos de corte. Este experimento foi conduzido para comparar o efeito e a dose resposta do produto Ava Cid P (composto por substância húmica, butirato de sódio 30% protegido e uma pequena porção de acidificantes) suplementado na dieta, sobre a performance, resposta imune e saúde intestinal de frangos de corte. O experimento seguiu um design inteiramente casualizado, envolvendo um arranjo fatorial 2 x 5 (2 s

APA, Harvard, Vancouver, ISO, and other styles

31

MANGIONI, DAVIDE. "A MULTIDISCIPLINARY APPROACH AGAINST ANTIMICROBIAL RESISTANCE: INTEGRATING IMMUNITY, MICROBIOLOGICAL FACTORS AND CLINICAL CARE TO FACE THE THREAT OF KLEBSIELLA PNEUMONIAE-CARBAPENEMASE (KPC)-PRODUCING KLEBSIELLA PNEUMONIAE." Doctoral thesis, Università degli Studi di Milano, 2022. http://hdl.handle.net/2434/888958.

Full text

Abstract:

BACKGROUND: Klebsiella pneumoniae-carbapenemase (KPC)-producing K. pneumoniae (KPC-Kp) accounts for a third of invasive strains of Kp in Italy and is responsible for increased morbidity and mortality. Host and bacterial factors involved in KPC-Kp colonization and/or infection are not yet clearly characterized. METHODS: Observational, prospective, multicenter national study part of the project Ricerca Finalizzata 2016 (GR-2016-02362572). Patients were enrolled from 03/2019 to 08/2021. Patients enrolled in a previous study at one of the participating centers (09/2017-05/2018) were included in t

APA, Harvard, Vancouver, ISO, and other styles

32

Souza, Maria do Carmo. "Efeito da infecção crônica por Toxoplasma gondii durante a sepse polimicrobiana experimental." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/17/17147/tde-19062013-122137/.

Full text

Abstract:

A maioria dos estudos da interação parasito-hospedeiro tem focado na interação de um único patógeno. Porém, o hospedeiro em um ambiente natural é comumente exposto a múltiplos patógenos sequencialmente ou mesmo simultaneamente. Diversos estudos têm utilizado o modelo de Ligadura e perfuração do Ceco (CLP) para estudar a sepse, mas nenhum deles apresentou modelo de coinfecção ou estudo avaliando o papel de infecções prévias no desfecho da sepse polimicrobiana experimental. Neste contexto, nossa hipótese é de que a infecção crônica por parasitos poderia alterar o curso da resposta durante a seps

APA, Harvard, Vancouver, ISO, and other styles

33

Dupraz, Louise. "Régulation des lymphocytes T innés par le microbiote intestinal Enterobacteriaceae are essential for the modulation of colitis severity by fungi Impaired Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota Is a Key Factor in Metabolic Syndrome." Thesis, Sorbonne université, 2019. http://www.theses.fr/2019SORUS598.

Full text

Abstract:

Dès la naissance, un très grand nombre de micro-organismes commensaux tels que bactéries, levures et virus colonise le tractus gastro-intestinal humain. Ce microbiote intestinal est essentiel pour développer les défenses immunitaires de l'hôte contre les infections, permettre une réparation tissulaire et un métabolisme nutritionnel adéquat. Les lymphocytes T gamma-delta, ou lymphocytes T innés sont des cellules T résidentes dans les tissus, impliquées dans l’inflammation intestinale telle que les maladies inflammatoires chroniques de l’intestin (MICI). Placée à l’interface entre l’immunité inn

APA, Harvard, Vancouver, ISO, and other styles

34

Sencio, Valentin. "Impact du microbiote intestinal sur les surinfections bactériennes post-grippales." Thesis, Lille, 2020. http://www.theses.fr/2020LILUS030.

Full text

Abstract:

Introduction: Le virus influenza A (IAV) est responsable d’épidémies de grippes chaque année, et de pandémies tous les 10 à 15 ans. Des infections bactériennes graves (infections à pneumocoques) peuvent survenir suite à l’infection grippale et contribuent à la morbidité et à la mortalité excessive de la grippe. L'infection par IAV réduit l'immunité antibactérienne, favorisant le développement local des bactéries et leur dissémination. Il a été démontré que le microbiote intestinal a un impact sur les réponses immunitaires de l'hôte. La déplétion (traitement antibiotique) ou l'absence (souris s

APA, Harvard, Vancouver, ISO, and other styles

35

MEAZZI, SARA. "THE INTERPLAY BETWEEN HOST DEFENSES AND SYSTEMIC PATHOGENS IN PROMOTING DISEASES OF COMPANION ANIMALS." Doctoral thesis, Università degli Studi di Milano, 2020. http://hdl.handle.net/2434/709076.

Full text

Abstract:

Il microbiota intestinale (insieme dei microrganismi che si trovano all’interno dell’apparato gastroenterico) svolge diverse funzioni e, tra queste, di particolare interesse è il suo rapporto con il sistema immunitario. Infatti, diversi studi hanno evidenziato la presenza di disbiosi non solo in corso di patologie gastroenteriche, ma anche autoimmuni ed infettive. Gli studi in medicina veterinaria sull’argomento sono ancora pochi e proprio per questo motivo, all’interno di questo progetto, è stato scelto di indagare la possibile relazione tra il microbiota intestinale e due particolari patolog

APA, Harvard, Vancouver, ISO, and other styles

36

Lenoir, Loïc. "Effet protecteur des polyphénols de la verveine odorante dans un modèle d'inflammation colique chez le rat." Phd thesis, Université d'Auvergne - Clermont-Ferrand I, 2011. http://tel.archives-ouvertes.fr/tel-00719693.

Full text

Abstract:

La consommation de polyphénols, micronutriments largement répandus dans lesaliments d'origine végétale, a été associée à la diminution du risque de développement denombreuses pathologies telles que maladies cardiovasculaires, maladies neurodégénérativesou cancers. Cet effet des polyphénols s'explique en partie par leurs propriétés antioxydanteset anti-inflammatoires. Du fait de leur faible absorption au niveau de l'intestin grêle, lespolyphénols sont présents en grande quantité dans le côlon où ils peuvent exercer cespropriétés. L'inflammation intestinale fait interagir le système immunitaire

APA, Harvard, Vancouver, ISO, and other styles

37

Fischer, André. "Wechselwirkungen der intestinalen Mikroflora und des angeborenen Immunsystems bei entzündlichen Erkrankungen im Gastrointestinaltrakt." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2007. http://dx.doi.org/10.18452/15663.

Full text

Abstract:

Die chronisch-entzündlichen Darmerkrankungen Morbus Crohn und Colitis ulzerosa sind wiederkehrende, nicht heilbare, immunvermittelte Krankheiten unklarer Ursache. Genetische Prädisposition und Umweltfaktoren können die Barrierefunktion der Darmmukosa stören, so dass eine überschiessende Entzündungsreaktion folgt, die durch kommensale Bakterien der normalen Darmflora verstärkt wird. Die Infektion mit H. pylori im Magen kann zu Gastritis, Ulkuskrankheit und der Entstehung von MALT-Lymphomen und Magenkarzinomen führen. An der Erkennung von bakteriellen Bestandteilen im Gastrointestinaltrakt sind

APA, Harvard, Vancouver, ISO, and other styles

38

Chang, Nai Chung, and 張乃中. "Gut Microbiota Modulates Lung Immunity Against Mycobacterial Infection." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/67811436267881247547.

Full text

Abstract:

碩士<br>長庚大學<br>醫學生物技術暨檢驗學系<br>100<br>Adequate induction of protective immunity is essential to control virulent mycobacterial infection. Homeostasis of gut microbiota via pattern-recognition receptors (PRRs) has been linked to modulation of local and systemic immunity, whereas the role in mycobacterial pulmonary infection is unknown. Here, we show that gut microbiota is critical for regulation of lung immunity against M. kansasii-induced pulmonary infection in mice. Depleted commensal microbiota by antibiotics cocktail (ABX) or neomycin leads to mice succumbing to disseminated M. kansasii infec

APA, Harvard, Vancouver, ISO, and other styles

39

Huang, Shiang-Fen, and 黃祥芬. "Relationship between Gut microbiome and innate immunity in patients with Mycobacterium tuberculosis infection." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/mnv2u7.

Full text

Abstract:

博士<br>國立陽明大學<br>臨床醫學研究所<br>107<br>The manifestation after Mycobacteirum tuberculosis (MTB) infection into the human can be characterized into active TB and latent TB infection (LTBI). The life-long incidence of active TB is around 10%, and most of people are at LTBI status. The active TB can be diagnosed according to the clinical symptoms, inflammatory response, and microbiological evidence from clinical specimens. The LTBI only can be detected by interferon gamma releasing test from blood sample in life host. The reactivation of active TB from LTBI could be prevented by administration with is

APA, Harvard, Vancouver, ISO, and other styles

40

Horrocks, Sadie Lyn. "The Effects of Probiotic and Eimeria on Gut Morphology and Humoral Immunity in Broilers." Thesis, 2010. http://hdl.handle.net/1969.1/ETD-TAMU-2010-12-8788.

Full text

Abstract:

Coccidiosis has a negative economic impact on the commercial poultry industry, and probiotics are beneficial bacteria that aid in maintaining healthy gut microflora. We hypothesized that probiotic administration would positively affect gut morphology and increase IgG secretion during an Eimeria challenge, which was evaluated by measuring total chicken IgG and gut morphology (villus height, villus width, villus surface area, crypt depth, villus height to crypt depth ratio and lamina propria thickness). On day-of-hatch, broilers were placed into floor pens with 50 percent pine shavings and 50 pe

APA, Harvard, Vancouver, ISO, and other styles

41

Lai, Yu-Ni, and 賴育妮. "Effects of Glutamine on Systemic and Mucosal Immunity in Rats with Gut-derived Sepsis." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/83720487955644403440.

Full text

Abstract:

碩士<br>臺北醫學大學<br>保健營養學系<br>92<br>This study investigated the effect of Gln-enriched diets before and Gln-containing total parenteral nutrition (TPN) after sepsis or both on mucosal and systemic immunity in rats with gut-derived sepsis. Male Wistar rats were assigned to the control and 4 experimental groups. The control and groups 1 and 2 were fed a semipurified diet, while groups 3 and 4 had part of the casein replaced with 25% of total nitrogen as Gln. After feeding the diets for 10 d, sepsis was induced by cecal ligation and puncture (CLP), whereas the control group underwent sham operation;

APA, Harvard, Vancouver, ISO, and other styles

42

Wang, Yi-Yun, and 王怡云. "Effects of Arginine Supplementation on the Systemic and Mucosal Immunity in Rats with Gut-derived Sepsis." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/60918650038181135505.

Full text

Abstract:

碩士<br>台北醫學院<br>保健營養學研究所<br>90<br>This study investigated the effect of arginine (Arg) supplementation before or/and after sepsis on nutrient metabolism and mucosal immunity in rats. Male Wistar rats were assigned to four groups. Group 1 and 2 fed with semipurified diet, group 3 and 4 replaced part of casein with 2% of total calorie as Arg. After feeding the experimental diets for 10 days, sepsis was induced by cecal ligation and puncture (CLP), at the same time internal jugular vein was cannulated. All rats were maintained with total parenteral nutrition (TPN) for 3 days. Group 1 and 2 in

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!