Relevant bibliographies by topics / Gynostemma pentaphyllum – Therapeutic use

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Academic literature on the topic 'Gynostemma pentaphyllum – Therapeutic use'

Author: Grafiati
Published: 20 February 2023
Last updated: 21 February 2023

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Journal articles on the topic "Gynostemma pentaphyllum – Therapeutic use"

1

Navrátilová, Zdeňka. "Gynostemma pentaphyllum - active compounds and therapeutic effects." Praktické lékárenství 13, no. 3 (October 1, 2017): 116–18. http://dx.doi.org/10.36290/lek.2017.015.

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Liang, Renji, Jinzheng Wu, Ronghua Lin, Liling Ran, Bo Shu, and Hao Deng. "Molecular Mechanisms of Gynostemma pentaphyllum in Prevention and Treatment of Non-Small-Cell Lung Cancer." Evidence-Based Complementary and Alternative Medicine 2022 (September 6, 2022): 1–8. http://dx.doi.org/10.1155/2022/9938936.

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Objective. Lung cancer represents the leading cause of cancer death on a global scale. Gynostemma pentaphyllum (G. pentaphyllum), a traditional medicinal material with a high medicinal and health value, has recently been reported for its anticancer activity. However, the pharmacological mechanism of G. pentaphyllum in non-small-cell lung cancer (NSCLC) remains to be elucidated. Methods. The active ingredients of G. pentaphyllum were obtained from the TCMSP database and known therapeutic targets of NSCLC from the GeneCards and OMIM databases. Disease-drug common targets are subjected to protein-protein interaction (PPI), GO enrichment analysis, and KEGG pathway enrichment analysis. A molecular docking strategy was performed to verify the interaction between molecules. Results. We found a total of 24 compounds of G. pentaphyllum fulfilling OB ≥ 30% concomitant with DL ≥ 0.18 and corresponding 81 target genes in the TCMSP database, with 5062 NSCLC-related genes collected in the GeneCards and OMIM databases. The network consisting of the disease-target compound was obtained, including 8 active ingredients and 69 common targets. The PPI network with 65 nodes and 645 edges was visualized. After functional enrichment analysis, it was revealed that the therapeutic effects of G. pentaphyllum on NSCLC were achieved through response to ketone, gland development, and cellular response to xenobiotic stimulus. After molecular docking analysis, it was revealed that the two active ingredients of G. pentaphyllum, quercetin and rhamnazin, bound well and stably to their targets (MYC, ESR1, and HIF1A). Conclusion. Our study, based on network pharmacology, identifies active ingredients, targets, and pathways model mechanism of G. pentaphyllum when it is used to treat NSCLC.
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Kim, Min Young. "Cytotoxicity and acute toxicity evaluation of hydrogen-rich Gynostemma pentaphyllum Makino distillate." Journal of Applied and Natural Science 14, no. 3 (September 16, 2022): 771–76. http://dx.doi.org/10.31018/jans.v14i3.3569.

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Hydrogen-rich Gynostemma pentaphyllum Makino distillate (HRGD) consists of Gynostemma pentaphyllum Makino steam distillate with hydrogen gas. Although both G. pentaphyllum Makino and hydrogen-rich water are well known for their biological and medical benefits, there is a lack of information on their safety and toxicity in vivo acute oral toxicity test and in vitro cytotoxicity method. The current study aimed to assess the cytotoxicity and acute oral toxicity of HRGD as a part of a safety evaluation using rat and human cell models. HRGD was administered orally once by gavage to male and female Sprague-Dawley rats at doses of 0, 2500, and 5000 mg/kg. Cytotoxicity assay was conducted in vitro at various concentrations in 10 different human normal and cancer cell lines; TK6 (human normal lymphomablastoid cells), Chang (human hepatic cells), 16HBE14o- (human bronchial epithelial cells), URotsa (human urothelium cells), MCF (human breast cancer cells), Hela (human cervical cancer cells), A375 (human malignant melanoma cells), HCT116 (human colon cancer cells), HepG2 (human liver cancer cells) and A549 (human non-small cell lung adenocarcinoma cells). From a 14-day study in rats, we observed no compound-related changes in mortality, clinical signs, body weight, food/water consumption, organ weight and gross pathology in all dose group. The result of in vivo acute toxicity shows that no observed adverse effect level of HRGD was below 5000 mg/kg for both sexes of rats, and the minimal lethal dose was considered to be more than 5000 mg/kg. HRGD also had no in vitro cytotoxicity against all tested cells. The present study data indicated that HRGD may contain bioactive compounds of potential therapeutic significance that are relatively safe from toxic effects.
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Li, Xiao-Li, Zheng-Hui Wang, Yong-Xi Zhao, Su-Ju Luo, Ding-Wei Zhang, Sheng-Xiang Xiao, and Zhen-Hui Peng. "Purification of a polysaccharide from Gynostemma pentaphyllum Makino and its therapeutic advantages for psoriasis." Carbohydrate Polymers 89, no. 4 (August 2012): 1232–37. http://dx.doi.org/10.1016/j.carbpol.2012.04.001.

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Chen, Jung-Chou, Chin-Chuan Tsai, Leih-Der Chen, Hing-Ho Chen, and Wen-Chuang Wang. "Therapeutic Effect of Gypenoside on Chronic Liver Injury and Fibrosis Induced by CCl4 in Rats." American Journal of Chinese Medicine 28, no. 02 (January 2000): 175–85. http://dx.doi.org/10.1142/s0192415x00000222.

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Gypenoside is a saponins extract derived from the Gynostemma pentaphyllum. The purpose of this study was to evaluate the hepatoprotective and antifibrotic potential of Gypenoside on chronic liver injury induced by CCl 4 for 8 wks. The results indicated that the increase of SGOT, SGPT activities in CCl 4 liver injury were significantly reduced by treatment with Gypenoside. It also elevated the A/G ratio. For the study of anti-fibrotic potential, Gypenoside reduced the collagen content by 33%. These phenomena were confirmed by pathologic observation; thinner bands of liver collagen were found. The results suggest that Gypenoside has hepatoprotective and anti-fibrotic activities.
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Zhong, Jiao, and Lu Wang. "Gypenoside XVII Inhibits High Glucose-Induced Apoptosis and Facilitates Osteogenic Differentiation in MC3T3-E1 Cells." Current Topics in Nutraceutical Research 20, no. 1 (February 26, 2021): 129–34. http://dx.doi.org/10.37290/ctnr2641-452x.20:129-134.

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Osteoporosis is a systemic bone disease characterized by compromised bone strength, which predisposes the individual to an increased risk of fractures of the hip, spine, and other skeletal sites. Gynostemma pentaphyllum (of the family Cucurbitaceae) is known to reduce blood lipid, prevent arteriosclerosis, inhibit oxidation, reduce blood glucose, and regulate immunity. Gypenoside XVII is one of the bioactives in G. pentaphyllum, which inhibits receptor activator of nuclear factor-kappa B ligand-induced osteoclast production. Herein, we show that Gypenoside XVII improves the survival of MC3T3-E1 under high glucose environment. It also inhibits the apoptosis of MC3T3-E1 cells in high glucose environment. In addition, Gypenoside XVII promotes osteogenic differentiation of MC3T3-E1 cells in high glucose environment. Mechanically, we found that Gypenoside XVII inhibited high glucose-induced apoptosis and facilitated osteogenic differentiation via activating the PI3K/AKT pathway. These data suggest that Gypenoside XVII might be a potential therapeutic drug in the treatment of osteoporosis.
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Wang, Miao, Fei Wang, Yinan Wang, Xiaonan Ma, Min Zhao, and Chunjie Zhao. "Metabonomics Study of the Therapeutic Mechanism of Gynostemma pentaphyllum and Atorvastatin for Hyperlipidemia in Rats." PLoS ONE 8, no. 11 (November 1, 2013): e78731. http://dx.doi.org/10.1371/journal.pone.0078731.

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Li, Kaijun, Chao Ma, Haoyu Li, Sooranna Dev, JianFeng He, and Xiaosheng Qu. "Medicinal Value and Potential Therapeutic Mechanisms of Gynostemma pentaphyllum (Thunb.) Makino and Its Derivatives: An Overview." Current Topics in Medicinal Chemistry 19, no. 31 (January 3, 2020): 2855–67. http://dx.doi.org/10.2174/1568026619666191114104718.

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: Gynostemma pentaphyllum (Thunb.) Makino (GpM) and its derivatives, especially gypenosides (Gyps), are widely used as safe and convenient natural herbal drugs for the treatment of many diseases for a long time, and Gyps have different oral bioavailability (OB) values and low ability to cross the blood-brain barrier (BBB). The effects of GpM and isolates on fibrosis, inflammation, oxidation, proliferation and migration are proved. GpM shows bidirectional regulation effect on proliferation, oxidation and apoptosis in tumor and non-tumor cells. GpM and its extractions can resist proliferation, activate oxidation and apoptosis in tumor cells and have opposite effects on non-tumor cells. We succinctly present some current views of medicinal value and potential therapeutic mechanisms of GpM and its derivatives.
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9

Xing, Shao-Fang, Lin-Hua Liu, Ma-Li Zu, Man Lin, Xin-Fang Zhai, and Xiang-Lan Piao. "Inhibitory Effect of Damulin B from Gynostemma pentaphyllum on Human Lung Cancer Cells." Planta Medica 85, no. 05 (December 18, 2018): 394–405. http://dx.doi.org/10.1055/a-0810-7738.

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AbstractDamulin B, a dammarane-type saponin from steamed Gynostemma pentaphyllum, exhibits the strongest activity against human lung carcinoma A549 cells among the isolated active saponins. In this study, the structure-activity relationship of a series of saponin compounds was discussed. The inhibitory effect of damulin B on human lung cancer A549 and H1299 cells was investigated from apoptosis, cell cycle, and migration aspects. In vitro, human lung cancer cells were more susceptible to damulin B treatment than human normal fibroblasts. Damulin B exhibited a strong cytotoxic effect, as evidenced by the increase of apoptosis rate, reduction of mitochondrial membrane potential (MMP), generation of reactive oxygen species, and G0/G1 phase arrest. Furthermore, damulin B activated the following: both intrinsic and extrinsic apoptosis pathways along with early G1 phase arrest via the upregulation of the Bax, Bid, tBid, cleaved caspase-8, and p53 expression levels; downregulation of the procaspase-8/-9, CDK4, CDK6, and cyclin D1 expression levels; and more release of cytochrome c in the cytoplasm. In addition, antimigratory activities and suppressive effects on metastasis-related factors, such as MMP-2 and MMP-9, accompanied by the upregulation of IL-24 were revealed. Altogether, the results proved that damulin B could inhibit human lung cancer cells by inducing apoptosis, blocking the cell cycle at early G0/G1 phase and suppressing the migration. Hence, damulin B has potential therapeutic efficacy against lung cancer.
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10

Mastinu, Andrea, Sara Anna Bonini, Marika Premoli, Giuseppina Maccarinelli, Eileen Mac Sweeney, Leilei Zhang, Luigi Lucini, and Maurizio Memo. "Protective Effects of Gynostemma pentaphyllum (var. Ginpent) against Lipopolysaccharide-Induced Inflammation and Motor Alteration in Mice." Molecules 26, no. 3 (January 22, 2021): 570. http://dx.doi.org/10.3390/molecules26030570.

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Gynostemma pentaphyllum (var. Ginpent) (GP) is a variety of Cucurbit with anti-inflammatory and antioxidant effects in patients. In this manuscript, the main components present in the dry extract of GP have been identified using Ultra High Performance Liquid Chromatography quadrupole-time-of-flight mass spectrometry (UHPLC/Q-TOF-MS). In addition, the anti-inflammatory action of GP was evaluated in animal models with acute peripheral inflammation and motor alteration induced by lipopolysaccharide. The results showed that GP dry extract is rich in secondary metabolites with potential antioxidant and anti-inflammatory properties. We found that the treatment with GP induced a recovery of motor function measured with the rotarod test and pole test, and a reduction in inflammatory cytokines such as interleukin-1β and interleukin-6 measured with the ELISA test. The data collected in this study on the effects of GP in in vivo models may help integrate the therapeutic strategies of inflammatory-based disorders.
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Dissertations / Theses on the topic "Gynostemma pentaphyllum – Therapeutic use"

1

Razmovski-Naumovski, Valentina. "Characterisation of Gynostemma Pentaphyllum Saponins Affecting Cholesterol Homeostasis." Thesis, The University of Sydney, 2004. https://hdl.handle.net/2123/29787.

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G. pentaphyllum (Thun.) Makino (Cucurbitaceae) is a perennial climbing herb, mainly found in southern tropical areas of Asia. Traditional use of the herb dates back 500 years and includes treatment for chronic tracheitis, bronchitis, infectious hepatitis, pyelitis and gastroenteritis. Its numerous medicinal applications include anti-inflammatory, anti-toxic, anti-tussive and expectoratory actions. The plant is not endemic to Australia and, as far as the author knows, has never been cultivated in this region. Therefore, cultivation of G. pentaphyllum was undertaken in Sydney, Australia in order assess its growth in a new environment and to provide local material for further chemical and biological assessment (Chapter 2). It was observed that G. pentaphyllum adapted successfully to the Sydney soil, light and water conditions and the yields provided ample supply of material for extraction purposes.
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Tsang, Ting Fung. "Mechanistic study of Chinese herbal medicines on melanogenesis and anti-melanoma effects." HKBU Institutional Repository, 2013. http://repository.hkbu.edu.hk/etd_ra/1506.

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3

Wu, Pui Kei. "Application of differential proteomic strategies to investigate the anti-cancer effects of Gynostemma pentaphyllum saponins in rat 6 fibroblast cell system." HKBU Institutional Repository, 2009. http://repository.hkbu.edu.hk/etd_ra/990.

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Wong, Wing Yan. "Proteomics analysis of anti-cancer effects of gynostemma pentaphyllum saponins in Apc min/+ colorectal cancer mouse model." HKBU Institutional Repository, 2012. https://repository.hkbu.edu.hk/etd_ra/1421.

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Books on the topic "Gynostemma pentaphyllum – Therapeutic use"

1

Michael, Blumert. Jiaogulan: China's "Immortality Herb"--Unlocking the Secrets of Nature's Powerful Adaptogen and Antioxidant. Torchlight Publishing, 1999.

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Saleeby, J. P. MD. Wonder Herbs. Xlibris Corporation, 2006.

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