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1

Karasaka, Lutfiye, and Neslisah Ulutas. "Point Cloud-Based Historical Building Information Modeling (H-BIM) in Urban Heritage Documentation Studies." Sustainability 15, no. 13 (2023): 10726. http://dx.doi.org/10.3390/su151310726.

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Integrating building information modeling (BIM) technology into historical and cultural heritage structures has resulted in historic building information modeling (H-BIM), an effective method for managing and documenting invaluable historical artifacts. H-BIM has the potential to aid with the design, restoration, and maintenance activities of historical buildings by properly integrating parametric data and deliberately assessing semantic information, thus progressing the 3D model’s performance. H-BIM also aims to conduct cultural heritage (CH) studies in a systematic manner by combining 3D modeling techniques and information management. The first step in this process is to conduct a suitable geomatic survey to build accurate 3D models. The most efficient modeling method is to employ 3D point cloud data that are acquired using the terrestrial laser scanning method. This study proposes a manual modeling strategy for urban historical buildings that falls within the scope of the H-BIM methodology. The proposed modeling strategy follows a workflow that inserts point cloud data into the BIM environment in order to create a 3D urban cultural heritage model using ontologies applied with the H-BIM methodology. With this objective in mind, the H-BIM model development platform Revit was used to model the object elements of the inheritance structure in 3D and save them in the BIM library. It is very important to model building elements separately in 3D modeling studies. The resulting BIM product sheds light on fundamental data for the future planning, design, operation, and maintenance processes of the building. Users can obtain data suitable for H-BIM by adding graphical and non-graphical data.
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Bolognesi, C. M., S. Balin, and A. La Conca. "MANAGEMENT OF H-BIM MODEL IN HOLOGRAPHIC VISUALIZATION." International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLVI-5/W1-2022 (February 3, 2022): 41–46. http://dx.doi.org/10.5194/isprs-archives-xlvi-5-w1-2022-41-2022.

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Abstract. This document aims to validate the workflow from a digital survey of a residential building of the early 900 century of historical value ready for future renovation to the transformation into a BIM model for its holographic fruition augmented by an automatically extraction of data and information contained within. Via Lulli is a low-cost residential district organized in courtyard blocks subject of future energy saving interventions; the research topic concerns the validation of the workflow from the 3D digital survey to the holographic visualization augmented with automatic extraction of information using the innovative Euclideon Hologram Table©.The possibility of interrogating an informative 3D BIM model visualized in a 3D space in front of the operator and not simply through a desktop is a completely new field in research with many potentialities; in the specific case study the abundance of these heritage buildings in the city must be considered as a relevant data to organize their whole renovation. After the previous validation of transforming the 3D BIM model to hologram, analysing the file formats, technical performance and specifications, file dimensions manageable, the successive implementation has been focused on the automatism of extraction of the different useful information from the model. The possibility of interacting to query the model in holographic representation represents an extraordinary tool for managing BIM which opens new research; it has been reached through tests for interoperability among formats, necessity of transformation of the BIM model without losing information and accuracy, friendly fruition in the Euclideon Hologram Table©.
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3

Stowe, D. F., B. M. Graf, S. Fujita, and G. J. Gross. "One-day cold perfusion of bimakalim and butanedione monoxime restores ex situ cardiac function." American Journal of Physiology-Heart and Circulatory Physiology 271, no. 5 (1996): H1884—H1892. http://dx.doi.org/10.1152/ajpheart.1996.271.5.h1884.

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Bimakalim (Bim), an opener of ATP-sensitive K+ (KATP) channels, was given alone or with 2,3-butanedione monoxime (BDM), a reversible uncoupler of contractility, to protect myocardial function during 1 day of hypothermia. Left ventricular pressure (LVP), coronary flow (CF), percent O2 extraction (%O2E), and cardiac efficiency were measured in 96 isolated, perfused guinea pig hearts divided into seven groups: 1) cold control (no drugs); 2) BDM; 3) Bim; 4) BDM + Bim; 5) BDM + glibenclamide (Glib, a blocker of KATP channels); 6) BDM + Bim + Glib; and 7) time control (6 h warm perfusion only). Drugs were given before, during, and initially after 22 h of low CF at 3.8 degrees C. At 26 h (cold groups) or 4 h (warm group) LVP (mmHg; means +/- SE) was similar for time control (94 +/- 4) and BDM + Bim (92 +/- 4) groups, lower and equivalent in the BDM (65 +/- 7) and BDM + Bim + Glib (64 +/- 7) groups, but LVP was higher than in the Bim group (46 +/- 3), and lowest in the cold control (30 +/- 8) group. In addition, only in the BDM + Bim group were basal CF, %O2E, and cardiac efficiency returned to values obtained in the time control group. Epinephrine increased LVP to that of the time control (106 +/- 3) group only in the BDM + Bim group (106 +/- 3) after hypothermia, and CF increases with adenosine, 5-hydroxytryptamine, and nitroprusside were similar to that of the time control group only in the BDM + Bim group after hypothermia. All of the effects of Bim were reversed by Glib. These results indicate that Bim, given with BDM, effectively preserves myocardial function and metabolism as well as inotropic and vasodilatory reserve during long-term hypothermic preservation as if the 1-day hypothermic state had not been instituted. Because the beneficial effects of Bim are blocked by Glib, the protective effect of Bim likely results from maintained KATP channel opening. Treatment with exogenous KATP openers may prove useful in preserving cardiac function in the transplanted heart.
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4

Ganah, Abdulkadir A., and Godfaurd A. John. "BIM and project planning integration for on-site safety induction." Journal of Engineering, Design and Technology 15, no. 03 (2017): 341–54. http://dx.doi.org/10.1108/jedt-02-2016-0012.

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Purpose The section of the research presented in this paper aims to review and explore health and safety (H&S) issues on construction sites. It has the sole intention of using better computer visualisation to meet the needs of site practitioners in understanding such H&S problems. Design/methodology/approach The methodology follows a traditional literature review approach to understand the development of building information modelling (BIM) technology up to its current status. A questionnaire survey was conducted to gather information on the embedding of H&S planning by site practitioners within the BIM environment. Findings BIM has the potential to be used in H&S planning procedures, particularly in those related to tasks on construction sites. A framework for an integrated visual tool is developed for better H&S practice on site. It may be used actively by all practitioners, starting with site induction and addresses, inter alia, personal hazard perception. Research limitations/implications This paper provides a foundation for developing a tool that helps construction personnel explore potential H&S risks on site before construction begins. By introducing a framework for integrating BIM and project planning, a prototype can be developed to demonstrate the application of the proposed framework. Originality/value The research presented in this paper introduces BIM usage during the construction stage as a tool that supports a H&S toolbox. The paper proposes the useful framework for better H&S practice on site that can be used actively by all practitioners. The intention is to find a way forward in addressing “real” H&S site issues that may not be easily understood by practitioners without the full aid of visualisation scenarios.
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5

Cardinali, Vieri, Anna Livia Ciuffreda, Massimo Coli, et al. "An Oriented H-BIM Approach for the Seismic Assessment of Cultural Heritage Buildings: Palazzo Vecchio in Florence." Buildings 13, no. 4 (2023): 913. http://dx.doi.org/10.3390/buildings13040913.

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H-BIM paradigms are constituted by 3-D informative contents documenting the current and past state of existing structures. Although the transversal vision and the multidisciplinary interpretation have been attributed to BIM models, in the field of monumental structures, these databases can be organized in different ways depending on the adopted protocol and classifications for the required output of the work. In this manuscript, an H-BIM approach targeted at collecting and providing useful information to execute seismic vulnerability analyses of monumental structures is presented. The BIM modeling followed a protocol based on the following steps: geometrical acquisitions, scan-to-BIM modeling, and informative data collection. The methodology has been applied to the oldest part of Palazzo Vecchio in Florence (IT), an important monumental masonry structure representing the political headquarter of the city since the Middle Ages. The parametric modeling was realized classifying the information according to structural perspectives based on the cognitive steps for the investigation of the existing structures. Finally, a seismic assessment has been realized through a simplified procedure developed for cultural heritage buildings. The outcomes of the evaluation are still part of the collected information of the H-BIM model, as an example of continuous improvement of the available contents of the database.
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Guerra de Oliveira, Sara, Salvatore Antonio Biancardo, and Andrej Tibaut. "Optimizing H-BIM Workflow for Interventions on Historical Building Elements." Sustainability 14, no. 15 (2022): 9703. http://dx.doi.org/10.3390/su14159703.

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Intervention projects for historical buildings depend on the quality of multidisciplinary data sets; their collection, structure, and semantics. Building information model (BIM) based workflows for historical buildings accumulate some of the data sets in a shared information model that contains the building’s geometry assemblies with associated attributes (such as material). A BIM model of any building can be a source of data for different engineering assessments, for example, solar and wind exposure and seismic vulnerability, but for historic buildings it is particularly important for interventions like conservation, rehabilitation, and improvements such as refurbishment and retrofitting. When the BIM model is abstracted to a semantic model, enabling the use of semantic technologies such as reasoning and querying, semantic links can be established to other historical contexts. The semantic technologies help historic building experts to aggregate data into meaningful form. Ontologies provide them with an accurate knowledge representation of the concepts, relationships, and rules related to the historic building. In the paper, we are proposing an improved workflow for the transformation of a heritage BIM model to a semantic model. In the BIM part the workflow demonstrates how the fully parametric modelling of historical building components is relevant, for example, in terms of reusability and adaptation to a different context. In the semantic model part, ontology reuse, reasoning, and querying mechanisms are applied to validate the usability of the proposed workflow. The presented work will improve knowledge-sharing and reuse among stakeholders involved in historic building projects.
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7

Lloyd, K. C., S. Amirmoazzami, F. Friedik, P. Chew, and J. H. Walsh. "Somatostatin inhibits gastrin release and acid secretion by activating sst2 in dogs." American Journal of Physiology-Gastrointestinal and Liver Physiology 272, no. 6 (1997): G1481—G1488. http://dx.doi.org/10.1152/ajpgi.1997.272.6.g1481.

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Somatostatin is a potent inhibitor of gastrin-stimulated acid secretion by activation of somatostatin receptor type 2 (sst2) in vivo, probably in part by blocking gastrin-stimulated histamine release from enterochromaffin-like cells expressing sst2. We propose that activation of sst2 may also regulate meal-stimulated acid secretion by blocking gastrin release from antral G cells. Using peptide analogs relatively selective for sst2 (NC-8-12), sst3 (BIM-23058), and sst5 (BIM-23052), we tested this hypothesis in two ways: first, in vivo by measuring plasma gastrin release during meal-stimulated acid secretion in dogs, and second, in vitro by measuring bombesin-stimulated gastrin release from an enriched culture of canine antral G cells. In vivo, a low dose (0.05 nmol.kg-1.h-1) of NC-8-12 inhibited acid secretion 56 +/- 16% without blocking gastrin release. A higher dose (1 nmol.kg-1.h-1) of NC-8-12 abolished acid secretion and inhibited gastrin release by 61 +/- 4%, whereas the highest dose (5 nmol.kg-1.h-1) inhibited gastrin release by 84 +/- 3%. Only the highest doses (5 nmol.kg-1.h-1) of BIM-23058 and BIM-23052 significantly inhibited gastrin release and acid secretion. In vitro, NC-8-12 (10(-9) M) reduced bombesin-stimulated gastrin release from antral G cells by 49 +/- 5%, whereas BIM-23058 and BIM-23052 were at least 100-fold less effective. These results indicate that somatostatin activation of sst2, but not sst3 or sst5, is the major pathway for somatostatin-induced inhibition of meal-stimulated gastrin release and acid secretion.
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8

Zizzari, P., H. Halem, J. Taylor, et al. "Endogenous Ghrelin Regulates Episodic Growth Hormone (GH) Secretion by Amplifying GH Pulse Amplitude: Evidence from Antagonism of the GH Secretagogue-R1a Receptor." Endocrinology 146, no. 9 (2005): 3836–42. http://dx.doi.org/10.1210/en.2005-0212.

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Abstract Ghrelin was purified from rat stomach as an endogenous ligand for the GH secretagogue (GHS) receptor. As a GHS, ghrelin stimulates GH release, but it also has additional activities, including stimulation of appetite and weight gain. Plasma GH and ghrelin secretory patterns appear unrelated, whereas many studies have correlated ghrelin variations with food intake episodes. To evaluate the role of endogenous ghrelin, GH secretion and food intake were monitored in male rats infused sc (6 μg/h during 10 h) or intracerebroventricularly (5 μg/h during 48 h) with BIM-28163, a full competitive antagonist of the GHS-R1a receptor. Subcutaneous BIM-28163 infusion significantly decreased GH area under the curve during a 6-h sampling period by 54% and peak amplitude by 46%. Twelve hours after the end of treatment these parameters returned to normal. Central treatment was similarly effective (−37 and −42% for area under the curve and −44 and −49% for peak amplitude on the first and second days of infusion, respectively). Neither peripheral nor central BIM-28163 injection modified GH peak number, GH nadir, or IGF-I levels. In this protocol, food intake is not strongly modified and water intake is unchanged. Subcutaneous infusion of BIM-28163 did not change plasma leptin and insulin levels evaluated at 1200 and 1600 h. On the contrary, central BIM-28163 infusion slightly increased leptin and significantly increased insulin concentrations. Thus, endogenous ghrelin, through GHS-R1a, acts as a strong endogenous amplifier of spontaneous GH peak amplitude. The mechanisms by which ghrelin modifies food intake remain to be defined and may involve a novel GHS receptor.
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9

López, Facundo, Pedro Lerones, José Llamas, Jaime Gómez-García-Bermejo, and Eduardo Zalama. "A Review of Heritage Building Information Modeling (H-BIM)." Multimodal Technologies and Interaction 2, no. 2 (2018): 21. http://dx.doi.org/10.3390/mti2020021.

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10

Biagini, Carlo, Paolo Ottobri, Neri Banti, and Andrea Bongini. "Validation processes of H-BIM models: a case study." IOP Conference Series: Materials Science and Engineering 949 (November 11, 2020): 012115. http://dx.doi.org/10.1088/1757-899x/949/1/012115.

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11

Croce, Valeria, Gabriella Caroti, Andrea Piemonte, Livio De Luca, and Philippe Véron. "H-BIM and Artificial Intelligence: Classification of Architectural Heritage for Semi-Automatic Scan-to-BIM Reconstruction." Sensors 23, no. 5 (2023): 2497. http://dx.doi.org/10.3390/s23052497.

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We propose a semi-automatic Scan-to-BIM reconstruction approach, making the most of Artificial Intelligence (AI) techniques, for the classification of digital architectural heritage data. Nowadays, Heritage- or Historic-Building Information Modeling (H-BIM) reconstruction from laser scanning or photogrammetric surveys is a manual, time-consuming, overly subjective process, but the emergence of AI techniques, applied to the realm of existing architectural heritage, is offering new ways to interpret, process and elaborate raw digital surveying data, as point clouds. The proposed methodological approach for higher-level automation in Scan-to-BIM reconstruction is threaded as follows: (i) semantic segmentation via Random Forest and import of annotated data in 3D modeling environment, broken down class by class; (ii) reconstruction of template geometries of classes of architectural elements; (iii) propagation of template reconstructed geometries to all elements belonging to a typological class. Visual Programming Languages (VPLs) and reference to architectural treatises are leveraged for the Scan-to-BIM reconstruction. The approach is tested on several significant heritage sites in the Tuscan territory, including charterhouses and museums. The results suggest the replicability of the approach to other case studies, built in different periods, with different construction techniques or under different states of conservation.
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Martín-Lerones, Pedro, David Olmedo, Ana López-Vidal, Jaime Gómez-García-Bermejo, and Eduardo Zalama. "BIM Supported Surveying and Imaging Combination for Heritage Conservation." Remote Sensing 13, no. 8 (2021): 1584. http://dx.doi.org/10.3390/rs13081584.

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As the basis for analysis and management of heritage assets, 3D laser scanning and photogrammetric 3D reconstruction have been probed as adequate techniques for point cloud data acquisition. The European Directive 2014/24/EU imposes BIM Level 2 for government centrally procured projects as a collaborative process of producing federated discipline-specific models. Although BIM software resources are intensified and increasingly growing, distinct specifications for heritage (H-BIM) are essential to driving particular processes and tools to efficiency shifting from point clouds to meaningful information ready to be exchanged using non-proprietary formats, such as Industry Foundation Classes (IFC). This paper details a procedure for processing enriched 3D point clouds into the REVIT software package due to its worldwide popularity and how closely it integrates with the BIM concept. The procedure will be additionally supported by a tailored plug-in to make high-quality 3D digital survey datasets usable together with 2D imaging, enhancing the capability to depict contextualized important graphical data to properly planning conservation actions. As a practical example, a 2D/3D enhanced combination is worked to accurately include into a BIM project, the length, orientation, and width of a big crack on the walls of the Castle of Torrelobatón (Spain) as a representative heritage building.
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Banfi, F., L. Barazzetti, M. Previtali, and F. Roncoroni. "HISTORIC BIM: A NEW REPOSITORY FOR STRUCTURAL HEALTH MONITORING." ISPRS - International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLII-5/W1 (May 15, 2017): 269–74. http://dx.doi.org/10.5194/isprs-archives-xlii-5-w1-269-2017.

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Recent developments in Building Information Modelling (BIM) technologies are facilitating the management of historic complex structures using new applications. This paper proposes a generative method combining the morphological and typological aspects of the historic buildings (H-BIM), with a set of monitoring information. This combination of 3D digital survey, parametric modelling and monitoring datasets allows for the development of a system for archiving and visualizing structural health monitoring (SHM) data (Fig. 1). The availability of a BIM database allows one to integrate a different kind of data stored in different ways (e.g. reports, tables, graphs, etc.) with a representation directly connected to the 3D model of the structure with appropriate levels of detail (LoD). Data can be interactively accessed by selecting specific objects of the BIM, i.e. connecting the 3D position of the sensors installed with additional digital documentation. Such innovative BIM objects, which form a new BIM family for SHM, can be then reused in other projects, facilitating data archiving and exploitation of data acquired and processed. The application of advanced modeling techniques allows for the reduction of time and costs of the generation process, and support cooperation between different disciplines using a central workspace. However, it also reveals new challenges for parametric software and exchange formats. The case study presented is the medieval bridge Azzone Visconti in Lecco (Italy), in which multi-temporal vertical movements during load testing were integrated into H-BIM.
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Lanzara, E., S. Scandurra, C. Musella, D. Palomba, A. di Luggo, and D. Asprone. "DOCUMENTATION OF STRUCTURAL DAMAGE AND MATERIAL DECAY PHENOMENA IN H-BIM SYSTEMS." International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLVI-M-1-2021 (August 28, 2021): 375–82. http://dx.doi.org/10.5194/isprs-archives-xlvi-m-1-2021-375-2021.

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Abstract. The paper presents the results of an experimental research activity aimed to individuate digital tools for an intelligent mapping of structural and material decay of historical buildings.The activities carried out are part of the context of Scan-to-BIM processes, as they establish a workflow that, starting from 3D survey data, leads to an information model enriched by information related to the conservation state of surfaces and to the structural characteristics of the real building. The experimentation has been performed with the support of a software house, looking forward to turning this workflow into an actual implementation on a BIM software. In this regard, this research becomes part of the context of the studies concerned in the digital management processes of the historical built heritage, setting and testing specific parametrical objects that add to H-BIM models the possibility of documenting and sharing graphical, numerical and descriptive data of decay phenomena and, through integrative information sheets, damage phenomena.
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Intignano, Mattia, Salvatore Antonio Biancardo, Cristina Oreto, et al. "A Scan-to-BIM Methodology Applied to Stone Pavements in Archaeological Sites." Heritage 4, no. 4 (2021): 3032–49. http://dx.doi.org/10.3390/heritage4040169.

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The transition from Building Information Modelling (BIM) to Heritage Building Information Modelling (H-BIM) is intended to pursue an adequate knowledge of the artefact that is to be preserved, progressively replacing the traditional methods of restoration and structural reinforcement projects with new tools for the management of both existing information and new interventions. The aim of the paper is to show the application of the H-BIM method to a stone pavement road located in the Archaeological Site of Pompeii. In detail, starting from a laser scanner-based survey, juxtaposed with coordinated points georeferenced through a total station, point clouds were handled by means of several BIM-based tools to perform the road design process, starting from the digital elevation model (DEM) and proceeding to the corridor representation. Subsequently, a visual programming application based on Python language was adopted to update the corridor information by means of the object property set. As preliminary results, a tool, complete with graphical and non-graphical information, is proposed to be used in conservation, maintenance and restoration projects.
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Diego, Petrin. "TECNOLOGIA BIM EM PROJETOS DE INFRAESTRUTURA DE RODOVIAS NO BRASIL." Revistaft 26, no. 117 (2022): 22. https://doi.org/10.5281/zenodo.7447222.

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Este artigo tem como objetivo demonstrar a tecnologia Building Information Modelling (BIM), ou Modelagem da Informação da Construção em projetos de infraestrutura de rodovias no Brasil. O Governo Federal lançou, no dia 16 de maio de 2018, estratégia para promover a inovação na indústria da construção. A Estratégia BIM BR, instituída pelo Decreto nº 9.377, de 17 de maio de 2018, tem como finalidade promover um ambiente adequado ao investimento em BIM e sua difusão no País. Desta forma, os novos Projetos de Infraestrutura exigem a utilização do BIM, que há inúmeras vantagens desde a elaboração do projeto, execução da obra e manutenções preventivas. Há diversas oportunidades para profissionais que se qualificarem, o mercado está em crescente desenvolvimento e se adaptando com essa nova tecnologia. 
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17

Khasanah, Felin, Hasti Riakara Husni, Bayzoni Bayzoni, and Amril Ma'ruf Siregar. "Pemodelan Gedung Perawatan Neurologi RSUD Dr. H. Abdul Moeloek Provinsi Lampung Menggunakan Building Information Modeling (BIM)." Jurnal Rekayasa Sipil dan Desain 11, no. 1 (2023): 52–60. https://doi.org/10.23960/jrsdd.v11i1.3049.

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Building Information Modeling (BIM) merupakan salah satu teknologi yang mempresentasikan digital dari karakteristik fisik dan fungsional dari suatu bangunan yang memuat informasi mengenai bangunan tersebut. Salah satu software yang mendukung konsep Building Information Modeling ialah software Autodesk Revit. Tujuan dari penelitian ini ialah memodelkan Gedung Perawatan Neurologi RSUD Dr. H. Abdul Moeloek Provinsi Lampung dengan menerapkankonsep BIM serta mendapatkan output volume pada pekerjaan cat dinding, pintu, dan jendela untuk setiap ruangan tiap lantai sebagai referensi pengambilan keputusan pada pemeliharaan dan perawatan. Pada penelitian ini menggunakan data as built drawing dan juga tinjauan lapangan. Pemodelan diawali dengan mengatur satuan, membuat grid dan level, membuat family struktur serta memodelkannya, membuat family arsitektur serta memodelkannya, membuat identity data, melakukan clash check, selanjutnya mengeluarkan hasil volume sesuai tujuan penelitian. Dari penelitian ini dapat disimpulkan bahwa memodelkan Gedung Perawatan Neurologi RSUD Dr. H. Abdul Moeloek Provinsi Lampung menggunakan konsep Building Information Modeling (BIM) lebih efektif karena output volume yang didapatkan tidak hanya secara menyeluruh tetapi dapatdikhususkan pada lantai maupun ruangan tertentu.Kata kunci : Building Information Modeling (BIM), Autodesk Revit, Pemeliharaan dan Perawatan
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Bartolini, Giada, Anna De Falco, Lorenzo Gianfranceschi, Massimiliano Martino, and Laura Vignali. "The Heritage Building Information Modeling Methodology for Structural Diagnosis: An Integrated System of Digital Models for the Baptistery of San Giovanni in Pisa." Heritage 7, no. 11 (2024): 6366–91. http://dx.doi.org/10.3390/heritage7110298.

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The structural diagnosis of monumental buildings necessitates organizing diverse cross-disciplinary data. The H-BIM procedure employs 3D digital models to create a comprehensive virtual repository, offering advantages in documentation access, interoperability, intervention design, cost evaluation, and maintenance management. This work proposes an approach to combining different models while addressing interoperability challenges by best exploiting their positive characteristics. After evaluating the advantages and limitations of textured-mesh and NURBS-based models, and virtual reality environments based on specific comparison criteria, an integrated system of these models within the H-BIM framework is proposed. The latter is applied to study the relevant case of the Baptistery of San Giovanni in Pisa, Italy. The integrated H-BIM model is designed primarily to facilitate the structural diagnosis of the monument, and illustrates how combining different 3D representations, each providing multiple information with different levels of detail, enhances its capabilities. This integration results in a more effective tool for the multidisciplinary conservation of cultural heritage, accommodating a wide range of data beyond structural aspects, thus fostering collaboration among professionals from various fields of expertise.
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Cohen, Alex W., José M. Carbajal та Richard C. Schaeffer. "VEGF stimulates tyrosine phosphorylation of β-catenin and small-pore endothelial barrier dysfunction". American Journal of Physiology-Heart and Circulatory Physiology 277, № 5 (1999): H2038—H2049. http://dx.doi.org/10.1152/ajpheart.1999.277.5.h2038.

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The purpose of this study was to test the hypothesis that tyrosine phosphorylation signaling events and protein kinase C (PKC) activation mediate vascular endothelial growth factor-A165(VEGF)-induced endothelial cell (EC) proliferation and barrier dysfunction in bovine pulmonary artery EC monolayers. A size-selective permeability assay showed that VEGF stimulated a delayed, prolonged (6–45 h), concentration-dependent (50–200 ng/ml, ∼1–4 nM) increase in the number of predominantly small-“pore” transport pathways (<60 Å) across EC monolayers. The tyrosine kinase inhibitor herbimycin A (HA) and the selective PKC inhibitor bisindolylmaleimide (BIM) prevented this phenomenon. After 6–24 h, VEGF-treated monolayers displayed an HA- and BIM-sensitive reorganization of β-catenin adherens junctions with fingerlike projections and the loss of β-catenin at sites of small paracellular hole formation. HA and BIM prevented the VEGF-induced increase in EC growth. HA blocked the VEGF-induced rapid and prolonged (10 min–45 h) increases in the phosphotyrosine (PY) contents of VEGF receptor 2, phospholipase C-γ1, paxillin, and β-catenin as well as ∼140- and 128- to 117-kDa proteins, whereas BIM inhibited only the tyrosine phosphorylation of β-catenin. These data suggest that VEGF initiates increased EC growth and chronic, small-pore endothelial barrier dysfunction by PY signaling through β-catenin that depends on PKC.
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.., Mais, Fayez .., and Sanaa AL Mezawy. "Developing a Model to Improve the Efficiency of Maintenance Management for Service Buildings Using BIM and Power BI: A Case Study." International Journal of BIM and Engineering Science 8, no. 1 (2024): 18–30. http://dx.doi.org/10.54216/ijbes.080102.

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[1] Seely, I.H.1987. Building Maintenance. London, Second Edition.470p. [2] Hawass, Zaki. Building diseases.(1992). Egypt, World of Books, first edition, 54 pages. (Arabic version) [3] Abu Al-Majd, Sharif. (1993). Cracking in concrete structures and methods of treating them. Egyptian Universities Publishing House - Al-Wafaa Library, Egypt, 143 pages. (Arabic version) [4] - Menoun, Muhammad Suleiman. (1996). Residential building maintenance. Master's thesis, Egypt, 150 pages. (Arabic version) [5] Saladin, Wael. (1997). An approach to improving maintenance efficiency in hotels through evaluating actual performance after occupancy. Egypt University of Science and Technology.20 p. (Arabic version) [6] Al-Khatam, J.( 2003). Buildings Maintenance Cost. Master Thesis, King Fahd University of Petroleum Minerals, 66P [7] Reffat,R; Gero,J; Peng, W.(2004). Using Data Mining on Building Maintenance During the Building Life Cycle. University of Tasmania, Australia,91-97. [8] Bin Akasha. (2007),Generic Process Model for Maintenance Management of School Buildings, Malaysia University, 92p [9] Chanter, B; Swallow. (2007) . Building Maintenance Management. 2nd. Blackwell Publishing. USA, 313p. [10] Abdulateef ,O.A. (2008). Building Maintenance in Malaysia.207-214.10 [11] Abdel Sabour, Manar. Hosni, Abdul Hadi. Issawi, Ahmed. Naseer, Ibrahim. (2009), Maintenance of residential facilities in the Arab Republic of Egypt between reality and hopes. Doctoral thesis at Ain Shams University. 472 pages. [12] Akcamete, A; Akinci, B. (2010). Potential Utilization of Building Information Models for PlanningMaintenance Activity. Carnegie Mellon University, USA,7P. [13] Al-Nadawi, Abdul Aziz. (2011). Business Intelligence is an advanced methodology for developing administrative processes in business organizations. Journal of Financial and Commercial Studies, Issue 2, 26 pages. (Arabic version) [14] Hadad,Ruba, ; Hassan, Bassam. (2011), Developing a methodology to analyze the factors affecting the maintenance costs of hospitals, Master’s thesis, Tishreen University, 115 pages. (Arabic version) [15] Eastman, C; Teicholz, P; Sacks, R; Liston, K,(2011). BIM handbook: A guide to building information modeling for owners, managers, designers, engineers and contractors, John Wiley Sons15 [16] Wang, Y; Chen, H. (2011). A 3-dimensional Visualized Approach for Maintenance and Management of Facilities. Information and Computational Technology, 468-47516... [17] Choka ,D.G. (2012);Study on The Impact of Management System on Maintenance Condition of Built Facilities(Case Study of Public Universities in Kenya).June , ,76p17 [18] Abdel Rahman, Hisham. Eid, Muhammad. Abdul Karim. (2013), A proposed methodology for the maintenance of basic general buildings in Egypt. Assiut University Journal of Engineering Sciences, Volume 41, Issue 1, January 257-289. (Arabic version)18 [19] Lopes,I, H.(2016). Requirements Specification of a Computerized Maintenance Management System-Case Study268-273. [20] Al-Hassan, Basil; Jarad, Fayez. (2016), Improving maintenance management for government buildings using building information modeling (BIM) techniques, Master’s thesis, Tishreen University, 133 pages(Arabic version) [21] Ibrahim, Reham. Arja, Muhammad. (2017). Developing a system to manage the school building maintenance process based on performance indicators. Master's thesis, Tishreen University, 164 pages(Arabic version) [22] Ahmed, Sonia; Saleem, Omar (2018), The Way to BIM, Guide for Individuals and Companies, Dar Al-Kutub Al-Ilmiyyah for Publishing and Distribution, 151 pages. (Arabic version). [23] Shaban, M.H. and Elhendawi, A.,( 2018). Building Information Modeling in Syria: Obstacles and Requirements for Implementation. International Journal of BIM and Engineering Science, 1(1). [24] Yusof, N., Ishak, S. Doheim, R., 2018. An Exploratory Study of Building Information Modelling Maturity in the Construction Industry. International Journal of BIM and Engineering Science, 1(1), pp. 6-19. [25] Elhendawi, A.I.N., 2018. Methodology for BIM Implementation in KSA in AEC Industry. Master of Science MSc in Construction Project Management), Edinburgh Napier University, UK. [26] Elhendawi, A., Omar, H., Elbeltagi, E. and Smith, A.,( 2019). Practical approach for paving the way to motivate BIM non-users to adopt BIM. International Journal of BIM and Engineering Science, 2(2), pp.1-22. [27] Banawi, A., Aljobaly, O., Ahiable, C. (2019). A comparative review of building information modeling frameworks. International Journal of BIM and Engineering Science, 2(2), 23-48. [28] Elhendawi, A., Smith, A. Elbeltagi, E., 2019. Methodology for BIM implementation in the Kingdom of Saudi Arabia. International Journal of BIM and Engineering Science, 2(1), pp. 1-21. [29] Al-Hassan, Basil; Omran, Jamal, Jarad, Fayez. (2019), Developing a system to support maintenance decisions in service buildings with an integrated methodology between knowledge management and BIM, PhD thesis, Tishreen University, 171 p. (Arabic version) [30] Al-Mazawi, Sanaa; Jarad, Fayez. Mia, Rana.(2019). Proposing a model for monitoring and evaluating the actual performance of managing the building maintenance process in public universities according to the theory of balanced performance (the case of Tishreen University) Tishreen University Journal, Engineering Sciences, Volume (41), Issue 4, 317-339. (Arabic version) [31] Morais ,G.A ; Casado,A.(2019). Building Maintenances Management Activities in A Public Institution . University de Pernambuco , Brazil .October,85-103 . [32] Al-Mazawi, Sanaa; Jarad, Fayez. Mia, Rana. (2020). Improving the efficiency of maintenance management in public universities through evaluating actual performance. Master's thesis, Tishreen University, 180 pages [33] Hamma-adama, M., Kouider, T. Salman, H., ( 2020). Analysis of barriers and drivers for BIM adoption. International journal of BIM and engineering science, 3(1), pp. 18-41. [34] Salamah, Taher, Shibani, Abdussalam, Alothman, Kheder: Improving AEC Project Performance in Syria Through the Integration of Earned Value Management System and Building Information Modelling: A Case Study, International Journal of BIM and Engineering Science, Vol. 5, No. 1, pp:75. [35] Safour, R., Ahmed, S. Zaarour, B., (2021). BIM Adoption around the World. International Journal of BIM and Engineering Science, 4(2), pp. 49-63. [36] Zaarour, B. Maihoub, N.(2021). Effect of needle diameters on the diameter of electro spun PVDF nanofibers. International Journal of BIM and Engineering Science, pp. 26-32. [37] Salami, H. Alothman, K.,( 2022). Engineering Training and its Importance for Building Information Modelling. International Journal of BIM and Engineering Science, 5(1), pp. 41-60 [38] Roumieh, N. Ahmed, S. (2022). Adopting Risk Management Professional Methodologies as an Effective Strategy to Protect Heritage Sites in Syria, International Journal of BIM and Engineering Science, Vol. 5, No. 1, pp: 61-72. [39] Saada, M. Aslan, H. (2022). The effectiveness of applying BIM in increasing the accuracy of estimating quantities for public facilities rehabilitation projects in Syria after the war, International Journal of BIM and Engineering Science, 5(2), pp: 08-1 [40] Mashali, A. El tantawi, A.,( 2022). BIM-based stakeholder information exchange (IE) during the planning phase in smart construction megaprojects (SCMPs). International Journal of BIM and Engineering Science, 5(1), pp. 08-19. [41] Dalloul. F. Saod. Lama,( 2023). Proposing a framework for introducing the concept of engineering digitization to develop curricula: case study - Tishreen University, Faculty of Civil Engineering. International Journal of BIM and Engineering Science (IJBES) Vol. 06, No. 01, PP. 34-51, 2023 [42] Al Mezawy,S; Jrad,F;Maya,R.(2023).Methodology to Improve Efficiency of Maintenance Management for Service Building Using Business Intelligence .Damascus University Journal for The Engineering Sciences ,12. [43] Saleh ,F, H., Elhendawi , A Darwish.A,S. and Farell, P.,( 2024). An ICT-based Framework for Innovative Integration between BIM and Lean Practices Obtaining Smart Sustainable Cities. Al-Rasheed International Private University International Journal of BIM and Engineering Science, 2(2), pp.68-75.
 [44] Fawaz Saleh, Ashraf Elhendawi, Abdul Salam Darwish, Peter Farrell. (2024). A Framework for Leveraging the Incorporation of AI, BIM, and IoT to Achieve Smart Sustainable Cities. Journal of Journal of Intelligent Systems and Internet of Things, 11 (2), 75- 84 (Doi: https:doi.org10.54216JISIoT.110207) [45] Evans, M., Farrell, P., Elbeltagi, E., Mashali, A. and Elhendawi, A., 2020. Influence of partnering agreements associated with BIM adoption on stakeholder's behaviour in construction mega-projects. International Journal of BIM and Engineering Science, 3(1), pp.1-20 [46] Elgendi, A.F., Elhendawi, A., Youssef, W.M.M. and Darwish, A.S., 2021. The Vulnerability of the Construction Ergonomics to Covid-19 and Its Probability Impact in Combating the Virus. International Journal of BIM and Engineering Science, 4(1), pp.01- 19. [47] Ahmed, S., Dlask, P., Selim, O. and Elhendawi, A., 2018. BIM Performance Improvement Framework for Syrian AEC Companies. International Journal of BIM and Engineering Science, 1(1), pp.21-41
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Biancardo, Salvatore Antonio, Francesca Russo, Rosa Veropalumbo, Viktoras Vorobjovas, and Gianluca Dell’Acqua. "Modeling Roman Pavements Using Heritage-BIM: A Case Study in Pompeii." Baltic Journal of Road and Bridge Engineering 15, no. 3 (2020): 34–46. http://dx.doi.org/10.7250/bjrbe.2020-15.482.

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The study of ancient stone pavements represents the necessary premise for planning and execution of treatments that considers the necessity of conservation. The approach to the integrated management of information derived through H-BIM has been applied to Via del Vesuvio, one of the main roads in the archaeological site of Pompeii in Naples, Italy. The digital terrain model was carried out using Autodesk Infraworks software. Then, using Autodesk Civil 3D and Revit software, the road was digitalized creating the 3D model that included road geometric information resulting from an on-site survey, material characteristics for each pavement layer, construction period and related construction cost information. Finally, based on the existing research works available in the literature review, using Autodesk Naviswork software, it was possible to implement in the 3D model the BIM fourth dimension, namely, the time related to the construction of Via Del Vesuvio in different eras. The interoperability between the adopted BIM authoring software was exploited. The adopted procedure can be considered a benchmark case in the technical literature of H-BIM for stone pavements, highlighting the advantages in the design field.
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Calì, Alfredo, Poliana Dias de Moraes, and Ângela Do Valle. "UNDERSTANDING THE STRUCTURAL BEHAVIOR OF HISTORICAL BUILDINGS THROUGH ITS CONSTRUCTIVE PHASE EVOLUTION USING H-BIM WORKFLOW." JOURNAL OF CIVIL ENGINEERING AND MANAGEMENT 26, no. 5 (2020): 421–34. http://dx.doi.org/10.3846/jcem.2020.12612.

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Knowledge is fundamental to understand the key characteristics of a heritage building. Furthermore, constructive analysis of a historical construction is central to research into its structural behavior. This work aims to increase the knowledge level of a historical construction by the understanding of the constructive evolution through Historical-Building Information Modeling (H-BIM) workflow. The research proposes a multidisciplinary approach applicable to the field of historical constructions, which is resumed in the followings steps: historical-critical analysis, material and soil characterization, data organization through H-BIM, qualitative static and dynamic structural analysis, validation of the results. The building of Quartel da Tropa – located in Florianópolis, Brazil – is used as a practical case study to show how the proposed research can be adapted to historical buildings. Such an impressive eighteen-century masonry construction is the largest troop barracks among Brazilian fortifications. The proposed approach allows the creation of a structural model from the architectural model with fewer uncertainties and less simplification, improving the knowledge path of historical constructions and its structural assessment. The historical-critical analysis and the H-BIM allow managing and presenting of the information useful to the understanding of the constructive phase evolution of a historical building.
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León-Robles, Carlos, Juan Reinoso-Gordo, and Juan González-Quiñones. "Heritage Building Information Modeling (H-BIM) Applied to A Stone Bridge." ISPRS International Journal of Geo-Information 8, no. 3 (2019): 121. http://dx.doi.org/10.3390/ijgi8030121.

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Certain historical works of civil engineering should be preserved as heritage monuments and when possible should continue serving the function they were designed for. Old stone bridges could be sustainably maintained but their conservation requires accurate documentation. In this study, we have scanned Ízbor bridge (1860) in Spain, and to facilitate conservation, we have modeled the ancient bridge using BIM (building information modeling). We propose a method and a model for this kind of bridge to be used as a reference for similar heritage monuments. Ízbor bridge modeled in this way will be useful for government planning and conservation agencies.
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Thravalou, S., A. Michopoulos, K. Alexandrou, and G. Artopoulos. "Energy retrofit strategies of built heritage: using Building Information Modelling tools for streamlined energy and economic analysis." IOP Conference Series: Earth and Environmental Science 1196, no. 1 (2023): 012115. http://dx.doi.org/10.1088/1755-1315/1196/1/012115.

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Abstract Dynamic simulation tools are widely used in the workflow of energy retrofitting historic buildings as they contribute to the development of an optimised, cost-effective renovation strategy. Additionally, Building Information Modelling (BIM) applied in heritage buildings can provide a holistic platform that improves collaboration between different stakeholders involved in the management, restoration and energy-retrofit of heritage buildings, by facilitating data sharing and project coordination. However, the use of BIM for energy simulation is rarely implemented due to emerging technical complexities regarding data interoperability. In response to the above shortcomings, the paper addresses the challenges of integrating a) dynamic energy performance analysis and b) financial feasibility analysis, using Heritage-BIM (H-BIM) tools. Insights and knowledge acquired through the case of a deep renovation of a historic building in ruin condition is presented. Specifically, an integrated H-BIM approach was developed by the authors in order to propose cost-effective energy efficiency upgrade measures. The energy improvement measures concern the upgrade of the thermal transmission of the building envelope, the incorporation of efficient heating, cooling and mechanical ventilation systems, as well as the incorporation of renewable energy systems. The economic feasibility study is based on widely used financial indicators, including life cycle cost analysis (LCCA). The proposed workflow aims to become a useful methodological tool for public authorities, assisting the attraction of financing mechanisms for the restoration and energy-upgrade of the historic building stock.
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Gutiérrez, Alejandro Roberto Issais, and Julio Cesar Martínez Espinosa. "Building and sustainability information modeling: An analysis of its thematic structure." Iberoamerican Journal of Science Measurement and Communication 4, no. 1 (2024): 1–15. http://dx.doi.org/10.47909/ijsmc.98.

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Objective. This study examines bibliographic production that addresses the intersection between building information modeling (BIM) and sustainability, considering business, academic, and scientific perspectives. The main objective is to analyze the relationship between BIM and sustainability to contextualize their development in these fields.
 Design/Methodology/Approach. A search was conducted in the Scopus database using the keywords "building information modeling" and "sustainability". The VOSviewer bibliometric tool was selected for thematic analysis, combining co-word analysis and the h-index. This methodology enabled the effective visualization of diagrams and thematic areas in all available publications.
 Results/Discussion. Four thematic groups were identified: new technologies and their applications, sustainable construction, sustainability and energy efficiency, and life cycle and environment management. A trend towards greater integration and synergy between BIM and sustainability was evident. The five main research lines around these topics were presented and discussed, which were: development of sustainability assessment methodologies based on BIM, optimization of the life cycle of buildings through BIM, innovation in sustainable materials and technologies, modeling of the resilience and adaptability of buildings, and standards and regulations for sustainability in BIM.
 Conclusions. The future is oriented towards BIM and sustainability due to their capacity to optimize construction efficiency, reduce waste, and promote sustainable practices.
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Carvalho, José, Manuela Almeida, Luís Bragança, and Ricardo Mateus. "BIM-Based Energy Analysis and Sustainability Assessment—Application to Portuguese Buildings." Buildings 11, no. 6 (2021): 246. http://dx.doi.org/10.3390/buildings11060246.

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Buildings are responsible for several negative impacts on the environment, most of them related to nonrenewable energy consumption, increasing the concern regarding buildings energy efficiency. In this context, computer software has been used to estimate the energy needs of the built environment, and the Building Information Modelling (BIM) methodology can be used to simplify this process. This study aims to validate a BIM-based framework to streamline the energy analysis of Portuguese buildings, based on the method of the national regulation for the thermal performance of residential buildings. Currently, designers need to spend considerable time assessing all the building characteristics and performing the mandatory calculations for energy performance analysis. It is also intended to link the results of the energy simulation with a Building Sustainability Assessment method—SBToolPT-H. The purpose is to demonstrate how it is possible to benefit from this approach to simultaneously improve building sustainability during the design stage. To do so, different case studies were modelled in Autodesk Revit and exported to a BIM energy tool to perform energy simulation analysis. The results were validated against the official assessment method of the Portuguese thermal regulation and were successfully used to assess the SBToolPT-H energy efficiency category. The research outcomes provide design teams with a reliable BIM-based framework to improve building energy performance and to develop thermal projects while enhancing building sustainability. It also increases the knowledge about the integration of sustainability assessment in the BIM environment, providing new insights for complete integration.
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Giovannini, E. C., A. Tomalini, E. Pristeri, L. Bergamasco, and M. Lo Turco. "DECAY CLASSIFICATION USING ARTIFICIAL INTELLIGENCE." International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLIII-B2-2021 (June 28, 2021): 847–54. http://dx.doi.org/10.5194/isprs-archives-xliii-b2-2021-847-2021.

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Abstract. The paper presents DECAI - DEcay Classification using Artificial Intelligence, a novel study using machine learning algorithms to identify materials, degradations or surface gaps of an architectural artefact in a semi-automatic way. A customised software has been developed to allow the operator to choose which categories of materials to classify, and selecting sample data from an orthophoto of the artefact to train the machine learning algorithms. Thanks to Visual Programming Language algorithms, the classification results are directly imported into the H-BIM environment and used to enrich the H-BIM model of the artefact. To date, the developed tool is dedicated to research use only; future developments will improve the graphical interface to make this tool accessible to a wider public.
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Saputri, Mellynia, Bayzoni Bayzoni, Hasti Riakara Husni, and Chatarina Niken Dwi wahyuni Setia Budi Utami. "Quantity Material Take Off Penulangan Kolom Zona B Gedung Perawatan Bedah Terpadu RSUD Dr.H. Abdul Moeloek dengan Building Information Modelling (BIM)." Jurnal Rekayasa Sipil dan Desain 11, no. 1 (2024): 1–8. https://doi.org/10.23960/jrsdd.v11i1.2982.

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In this era of globalization, technology is growing rapidly in all aspects of life, including in the field of infrastructure. Technological developments in the field of infrastructure can be seen from the many softwares that facilitate development work. The software then comes packaged in a program called Building information Modeling (BIM). One of the software of Building information Modeling (BIM) is a Autodesk Revit which is able to automatically generate Material Quantity Take Off (QMTO) which is used by contractors in making Bill Of Quantity (BOQ). in Quantity Material Take Off (QMTO) an important aspect that must be considered is reinforcement or reinforcement work. Therefore, the researchers reviewed the Quantity Material take Off (QMTO) reinforcement, especially the column in the integrated surgery building, RSUD Dr. H. Abdul Moeloek. Based the research that has been done using Autodesk Revit software, there are difference in the value of column reinforcement volume between calculations using conventional methods. Base of the results of the analysis, the value of column reinforcement volume with conventional methods is greater than using the BIM-based method with percentage difference of 6,54 %. In addition, the percentage of waste material is quite large, namely 9,61 %. Key words : Building Information Modeling (BIM), Autodesk Revit, Quantity Material Take off (QMTO), column reinforcement, Waste Material . Di era globalisasi ini, teknologi semakin berkembang pesat di seluruh aspek kehidupan termasuk dalam bidang infrastruktur. Perkembangan teknologi di bidang infrastruktur dapat dilihat dari banyaknya software-software yang memudahkan pekerjaan pembangunan. Software-software tersebut kemudian hadir dalam kemasan sebuah program yang disebut Building Information Modelling (BIM). Salah satu software dari Building Information Modelling (BIM) adalah Autodesk Revit yang mampu secara otomatis menghasilkan Quantity Material Take Off (QMTO) yang digunakan kontraktor dalam pembuatan Bill Of Quantity (BOQ). Pada Quantity Material Take Off (QMTO) aspek penting yang harus diperhatikan adalah tulangan atau pekerjaan penulangan. Oleh karena itu peneliti meninjau Quantity Material Take Off (QMTO) penulangan khususnya kolom pada Gedung Bedah Terpadu RSUD Dr. H. Abdul Moleoek. Berdasarkan penelitian yang telah dilakukan menggunakan Software Autodesk Revit terdapat perbedaan nilai volume penulangan kolom antara perhitungan menggunakan metode konvensional dan metode berbasis BIM. Berdasarkan hasil analisis didapat nilai volume penulangan kolom dengan metode konvensional lebih besar dibandingkan dengan menggunakan metode berbasis BIM dengan selisih persentase sebesar 6,54 %. selain itu didapatkan hasil persentase waste material yang cukup besar yaitu 9,61 %Kata kunci : Building Information Modelling (BIM), Autodesk Revit, Quantity Material Take Off (QMTO), Tulangan Kolom, Waste Material .
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Rossi, Adriana, Luis Palmero Iglesias, and Umberto Palmieri. "De la digitalización laser hacia el H-BIM: un caso de estudio." EGA Revista de Expresión Gráfica Arquitectónica 25, no. 38 (2020): 182. http://dx.doi.org/10.4995/ega.2020.12835.

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<p>Queriendo dar respuesta a las preguntas que el anterior estudio precedente efectuado con una estación total (Trimble S6 Vision) no pudo concretar, el artículo comenta los resultados obtenidos con las adquisiciones de digitalización láser 3D y las bases de datos fotográficas. La precisión, garantizada por la tecnología de medida, ha permitido medir la distancia entre el modelo numérico (discontinuo pero objetivo) y el modelo geométrico (continuo pero subjetivo). También se discute el grado de fiabilidad de los documentos e hipótesis relevantes basados en el razonamiento matemático como el comienzo de una cadena de trabajo digital compartida e interoperable. Los temas abordados se refieren a la virtualización de componentes geométricos manipulables paramétricamente (tratamiento de la geometría) que, a partir de la normativa vigente en materia de contratos públicos (BIM), se impone como prototipo para el proyecto de restauración y mantenimiento de edificios históricos (H-BIM) y, en particular, para el caso de estudio: la fábrica de cerámica artística, sita en Vietri sul Mare, (Salerno, Italia), construida entre 1953 y 1955, la cual se encuentra actualmente sujeta al Decreto Legislativo del 22 de enero de 2004.</p>
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Youssef, Fadia S., Mohamed L. Ashour, Hesham A. El-Beshbishy, Abdel Nasser B. Singab, and Michael Wink. "Metabolic Profiling of Buddleia indica Leaves using LC/MS and Evidence of their Antioxidant and Hepatoprotective Activity Using Different In Vitro and In Vivo Experimental Models." Antioxidants 8, no. 9 (2019): 412. http://dx.doi.org/10.3390/antiox8090412.

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LC-ESI-MS (Liquid Chromatography coupled with Electrospray Ionization Mass Spectrometry profiling of a methanol extract from Buddleia indica (BIM) leaves revealed 12 main peaks in which verbascoside and buddlenoid B represent the major compounds. The antioxidant and hepatoprotective activities of BIM were investigated using different in vitro and in vivo experimental models. BIM exhibited substantial in vitro antioxidant properties in DPPH· and HepG2 assays. Regarding CCl4 (carbon tetrachloride) induced hepatotoxicity in a rat model, oxidative stress markers became significantly ameliorated after oral administration of BIM. Lipid peroxide levels showed a 51.85% decline relative to CCl4-treated rats. Super oxide dismutase (SOD), total antioxidant status (TAS), and catalase (CAT) revealed a marked increase by 132.48%, 187.18%, and 114.94% relative to the CCl4 group. In a tamoxifen-induced hepatotoxicity model, BIM showed a considerable alleviation in liver stress markers manifested by a 46.06% and 40% decline in ALT (Alanine Transaminase) and AST (Aspartate Transaminase) respectively. Thiobarbituric acid reactive substances (TBARS) were reduced by 28.57% and the tumor necrosis factor alpha (TNF-α) level by 50%. A virtual screening of major secondary metabolites of BIM to TNF-alpha employing the C-docker protocol showed that gmelinoside H caused the most potent TNF- α inhibition as indicated from their high fitting scores. Thus, BIM exhibited a potent hepatoprotective activity owing to its richness in antioxidant metabolites.
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Parisi, P., M. Lo Turco, and E. C. Giovannini. "THE VALUE OF KNOWLEDGE THROUGH H-BIM MODELS: HISTORIC DOCUMENTATION WITH A SEMANTIC APPROACH." ISPRS - International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLII-2/W9 (January 31, 2019): 581–88. http://dx.doi.org/10.5194/isprs-archives-xlii-2-w9-581-2019.

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<p><strong>Abstract.</strong> The Building Information Modeling (BIM) in the Architectural Heritage field is constantly proving to be a fertile ground for the experimentation of innovative systems for the enhancement and management of cultural heritage. Regarding to the management of the entire process, the building field is increasing in efficiency from the construction to the management phase; conversely, the approach to historical buildings opens up interesting and heterogeneous scenarios, according to different levels of complexity. The presented work is the result of a collaboration between the Politecnico di Torino and the Escuela Técnica Superior de Arquitectura of Granada: the main scope was to create an historic building information model (H-BIM) of the building that today hosts the Faculty of Architecture (ETSAG), taking into account its historical past from the sixteenth century up to the present day, as the result of many modifications, extensions and different use classifications over time. According to this, the BIM methodology can be considered as a bridge between the archive documentation and the digital model, proving to be an effective tool as a data repository, semantically oriented, not only constituted by geometry, but also by alpha-numerical attributes, improving in effectiveness if it is directly related to formal language object oriented.</p>
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Tengku Md Fauzi, Tengku Sarah, Zunnur Alwani Ahmad Zaki, Wan Nur Afiqah Wan Anuar, Syaza Azhari, Nurul Hidayah Abdul Razak, and Nadrahtul Huda Misral. "Synthesis, Characterisation and Preliminary Evaluation of Bis-Indolylmethane Derivatives as Colorimetric Sensor for Metal Ions Detection." Sains Malaysiana 53, no. 8 (2024): 1925–35. http://dx.doi.org/10.17576/jsm-2024-5308-16.

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Heavy metal ions such as copper, chromium, and manganese are very harmful to both the environment and living organisms. Their presence in excess amount can harm the liver, kidneys, lungs, and other vital organs. A colorimetric sensor based on bis-indolylmethane (BIM) derivatives was preliminary studied to investigate their ability as a heavy metal ionophore with existence of H-bonding interactions between the indolic N–H functional groups and the metal ions. Five different BIM derivatives were synthesised involving condensation reaction between 2-methylindole and different substituted benzaldehydes, and were characterised using 1H and 13C NMR, FT-IR, and UV-Vis spectroscopy to confirm their molecular structure. Colorimetric sensing analysis involving metal screening with Cu2+, Mn2+ and Cr6+ ions via naked eye study showed compounds 1 and 5 had the most intense colour change, hence having the highest possibility to make interaction or to be bound to the metal ions. A further binding interaction study was conducted using UV-Vis titration analysis between compound 1 with the metal ions involving Cu2+ and Mn2+ and compound 5 with Cr6+, respectively, proved the synthesized BIM derivatives to act as a potential heavy metal ions colorimetric sensor.
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Croce, V., M. G. Bevilacqua, G. Caroti, and A. Piemonte. "CONNECTING GEOMETRY AND SEMANTICS VIA ARTIFICIAL INTELLIGENCE: FROM 3D CLASSIFICATION OF HERITAGE DATA TO H-BIM REPRESENTATIONS." International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLIII-B2-2021 (June 28, 2021): 145–52. http://dx.doi.org/10.5194/isprs-archives-xliii-b2-2021-145-2021.

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Abstract. Cultural heritage information systems, such as H-BIM, are becoming more and more widespread today, thanks to their potential to bring together, around a 3D representation, the wealth of knowledge related to a given object of study. However, the reconstruction of such tools starting from 3D architectural surveying is still largely deemed as a lengthy and time-consuming process, with inherent complexities related to managing and interpreting unstructured and unorganized data derived, e.g., from laser scanning or photogrammetry. Tackling this issue and starting from reality-based surveying, the purpose of this paper is to semi-automatically reconstruct parametric representations for H-BIM-related uses, by means of the most recent 3D data classification techniques that exploit Artificial Intelligence (AI). The presented methodology consists of a first semantic segmentation phase, aiming at the automatic recognition through AI of architectural elements of historic buildings within points clouds; a Random Forest classifier is used for the classification task, evaluating each time the performance of the predictive model. At a second stage, visual programming techniques are applied to the reconstruction of a conceptual mock-up of each detected element and to the subsequent propagation of the 3D information to other objects with similar characteristics. The resulting parametric model can be used for heritage preservation and dissemination purposes, as common practices implemented in modern H-BIM documentation systems. The methodology is tailored to representative case studies related to the typology of the medieval cloister and scattered over the Tuscan territory.
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Jha, Vikas Kumar, Sunil Kumar Patel, Devarapalli Chenna Rao, Kovuru Gopalaiah, and E. Siva Subramaniam Iyer. "The enhanced ultrafast dissociation of meso-hydrogen of bis(indolyl)methane derivatives under acidic conditions." RSC Advances 15, no. 19 (2025): 14778–86. https://doi.org/10.1039/d5ra02015h.

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The enhanced ultrafast dissociation of meso-H in BIM I under acidic condition. The bar graph shows the ratio of photoproduct and parent molecule at 500 fs time delay as a function of subsequent TA scans.
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35

Jasper, J. R., H. J. Motulsky, L. C. Mahan, and P. A. Insel. "Beta-adrenoceptor metabolism in wild-type, Gs, and protein kinase A-variant S49 cells." American Journal of Physiology-Cell Physiology 259, no. 1 (1990): C41—C46. http://dx.doi.org/10.1152/ajpcell.1990.259.1.c41.

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To determine the role of the stimulatory guanine nucleotide-binding protein, Gs, and adenosine 3',5'-cyclic monophosphate (cAMP)-dependent protein kinase in the basal metabolism of beta-adrenergic receptors in S49 lymphoma cells, we measured the return of receptor number and function after irreversible blockade of receptors. After inactivation of receptors with the irreversible ligand N8-(bromoacetyl)-N'-[3-(4-indolyoxy)-2-hydroxypropyl]-(2)-1,8-diam ino-p- methane (BIM), beta-adrenergic receptors (defined as [125I]iodocyanopindolol binding sites) reappeared in a biphasic manner, the faster phase having a half-time (t 1/2) of 3-8 h (approximately 50% of the sites) and the slower phase greater than 40 h. Although the slow phase is not readily explained, recovery of binding sites during the first 10 h matched recovery of receptor function after BIM treatment (as measured by stimulation of cAMP accumulation) and recovery of receptor sites after downregulation induced by the agonist isoproterenol. Thus quantifying receptor recovery during the first 10 h after BIM treatment appears to be a reasonable method for examining basal receptor metabolism in S49 cells. Measured in this way, metabolism of beta-adrenergic receptors is very similar in wild-type S49 and the following variant clones: cyc- (absent Gs alpha), UNC and H21a (defective Gs alpha), and kin- (lacking cAMP-dependent protein kinase activity). Although previous data have demonstrated that agonist-promoted downregulation of beta-adrenergic receptors requires functional receptor-Gs coupling, the current data suggest that neither Gs nor cAMP-dependent protein kinase activity plays an important role in the regulation of basal metabolism of beta-adrenergic receptors.(ABSTRACT TRUNCATED AT 250 WORDS)
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36

Wu, Yang, Yan Leng, Qingtao Meng, et al. "Suppression of Excessive Histone Deacetylases Activity in Diabetic Hearts Attenuates Myocardial Ischemia/Reperfusion Injury via Mitochondria Apoptosis Pathway." Journal of Diabetes Research 2017 (2017): 1–15. http://dx.doi.org/10.1155/2017/8208065.

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Background. Histone deacetylases (HDACs) play a pivotal role in signaling modification and gene transcriptional regulation that are essential for cardiovascular pathophysiology. Diabetic hearts with higher HDACs activity were more vulnerable to myocardial ischemia/reperfusion (MI/R) injury compared with nondiabetic hearts. We are curious about whether suppression of excessive HDACs activity in diabetic heart protects against MI/R injury. Methods. Diabetic rats were subjected to 45 min of ischemia, followed by 3 h of reperfusion. H9C2 cardiomyocytes were exposed to high glucose for 24 h, followed by 4 h of hypoxia and 2 h of reoxygenation (H/R). Results. Both MI/R injury and diabetes mellitus elevated myocardium HDACs activity. MI/R induced apoptotic cell death was significantly decreased in diabetic rats treated with HDACs inhibitor trichostatin A (TSA). TSA administration markedly moderated dissipation of mitochondrial membrane potential, protected the integrity of mitochondrial permeability transition pore (mPTP), and decreased cell apoptosis. Notably, cotreatment with Akt inhibitor partly or absolutely inhibited the protective effect of TSA in vivo and in vitro. Furthermore, TSA administration activated Akt/Foxo3a pathway, leading to Foxo3a cytoplasm translocation and attenuation proapoptosis protein Bim expression. Conclusions. Both diabetes mellitus and MI/R injury increased cardiac HDACs activity. Suppression of HDACs activity triggered protective effects against MI/R and H/R injury under hyperglycemia conditions through Akt-modulated mitochondrial apoptotic pathways via Foxo3a/Bim.
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Nabavian, Saghar, Reza Naderi, and Najmeh Asadi. "Determination of Optimum Concentration of Benzimidazole Improving the Cathodic Disbonding Resistance of Epoxy Coating." Coatings 8, no. 12 (2018): 471. http://dx.doi.org/10.3390/coatings8120471.

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This study is aimed to evaluate the effect of concentrated benzimidazole (BIM) on the cathodic disbonding (CP) of an epoxy coating applied on steel substrate. For this purpose, the polymeric coatings, formulated with different concentrations of BIM (0 wt.%, 0.5 wt.%, 0.75 wt.%, and 1 wt.%, were subjected to the CP test at the potential of −1.2 V vs. Ag/AgCl during 24 h immersion in 3.5 wt.% NaCl solutions. The optimum formulation was found through taking advantage of the CP test results, FESEM/EDX, and EIS data. Moreover, a pull-off test was used to measure the wet adhesion strength. For insight into the inhibition function of the organic inhibitor, the behavior of steel in the sodium chloride solutions, with and without BIM, was compared using EIS and surface analysis.
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38

Barazzetti, Luigi, and Fabio Roncoroni. "Generation of a Multi-Scale Historic BIM-GIS with Digital Recording Tools and Geospatial Information." Heritage 4, no. 4 (2021): 3331–48. http://dx.doi.org/10.3390/heritage4040185.

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This paper discusses the creation of an integrated historic BIM-GIS for the complex of San Pietro al Monte, an important Romanesque monument in Civate (Italy) inscribed in the UNESCO tentative list with other seven medieval Benedictine settlements. The reason behind the choice of an integrated H-BIM-GIS solution is motivated by the large extension of the considered area (about 30 km2) and the need for multi-scale digital information integrated into a 3D parametric environment. The model includes geospatial information at a territorial scale and in situ digital data capturing the complex at a higher level of detail. The work aims at exploring the pros and cons of a novel parametric 3D environment able to integrate both BIM and GIS data, methods, and processing tools in the case of historic buildings and sites.
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39

Soriano, Sulpicio G., Qian Liu, Jing Li, et al. "Ketamine Activates Cell Cycle Signaling and Apoptosis in the Neonatal Rat Brain." Anesthesiology 112, no. 5 (2010): 1155–63. http://dx.doi.org/10.1097/aln.0b013e3181d3e0c2.

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Background Prolonged exposure to ketamine results in accelerated neurodegeneration and neurocognitive deficits in the neonatal rats. Experimental models of neurodegeneration have implicated reentry of postmitotic neurons into the cell cycle, leading to cell death. The authors hypothesize that the ketamine-induced neuroapoptosis is partially due to aberrant cycle cell reentry. To explore this hypothesis, the authors characterized the effect of ketamine on the cell cycle signaling pathway in the developing rodent brain in vivo and in vitro. Methods Postnatal day 7 rat pups and primary neurons were used for the experiments. Each rat pup received five intraperitoneal doses of either saline or ketamine (5, 10, and 20 mg/kg/dose) at 90-min intervals over 6 h. Primary neurons were exposed to varying concentrations of ketamine to determine the dose and duration effects. The expression of cell cycle proteins (cyclin D1, cyclin-dependent kinase 4, and E2F1), Bcl2-interacting mediator of cell death (Bim), and activated caspase-3 was determined. The effect of cyclin D1 knockdown by small interfering RNA was also examined in primary neurons incubated in ketamine. Results Ketamine mediated a dose- and time-dependent increase in expression of cell cycle proteins and activated caspase-3. Cyclin D1, cyclin-dependent kinase 4, E2F1, Bim, and cleaved caspase-3 expression increased at 12 h and peaked at 24 h in vitro. Knockdown of cyclin D1 by small interfering RNA attenuated Bim and cleaved caspase-3 expression. Conclusion These findings support a model in which ketamine induces aberrant cell cycle reentry, leading to apoptotic cell death in the developing rat brain.
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40

Kaur, Baljeet S., Rodica Ouatu-Lascar, M. Bishr Omary, and George Triadafilopoulos. "Bile salts induce or blunt cell proliferation in Barrett's esophagus in an acid-dependent fashion." American Journal of Physiology-Gastrointestinal and Liver Physiology 278, no. 6 (2000): G1000—G1009. http://dx.doi.org/10.1152/ajpgi.2000.278.6.g1000.

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Barrett's esophagus (BE) results from acid and bile reflux and predisposes to cancer. We investigated the effect of bile salts, with or without acid, on cell proliferation in BE and assessed mechanism(s) involved. To mimic physiological conditions, biopsies of esophagus, BE, and duodenum were exposed to a bile salt mixture, either continuously or as a 1-h pulse, and were compared with control media without bile salts (pH 7.4) for ≤24 h. Similar experiments were also performed with acidified media (pH 3.5) combined with the bile salt mixture as a 1-h pulse. Cell proliferation was assessed by a [3H]thymidine incorporation assay with or without bisindolylmaleimide (BIM), a selective protein kinase C inhibitor. Bile salt pulses enhanced cell proliferation in BE without affecting cell proliferation in esophageal or duodenal epithelia. In the presence of BIM, there was complete obliteration of the bile salt-induced BE hyperproliferation. In contrast, 1-h pulses of bile salts in combination with acid significantly inhibited proliferation in BE but had no effect on esophagus or duodenum. We conclude that in BE explants, brief exposure to bile salts, in the absence of acid, increases proliferation, whereas exposure to a combination of bile salts and acid together inhibits proliferation.
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41

Yu, Haibin, Haojie Zhang, Yan Cheng, et al. "JNK pathway promotes hepatocyte apoptosis by inhibiting Bcl-2 and upregulating expressions of Bim, caspase-3 and caspase-9 after cardiopulmonary bypass." Tropical Journal of Pharmaceutical Research 19, no. 3 (2020): 519–24. http://dx.doi.org/10.4314/tjpr.v19i3.9.

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Purpose: To study the effect of Jun N-terminal kinase (JNK) signaling pathway on hepatocyte apoptosis in vivo and in vitro, and to elucidate the mechanism of action.
 Methods: TdT-mediated dUTP Nick-End Labeling (TUNEL) method was used to determine apoptosis in control and cardiopulmonary bypass (CPB) groups at 0, 3 and 6 hours after rat surgery. The expressions of JNK and p-c-Jun in liver tissues at 0, 3 and 6 h after surgery, and the levels of p-c-Jun, Bcl-2 and Bim following overexpression of JNK, were determined using Western blot assay. Human liver cell line HL-7702 was cultured and transfected with over-expressed JNK plasmid and empty plasmid. Proliferation of HL-7702 cells after JNK over-expression was assessed by Cell Counting Kit-8 (CCK-8), while quantitative real-time polymerase chain reaction (RT-qPCR) was employed to evaluate mRNA expression levels of caspase-3 and caspase-9 mRNA after JNK over-expression. Apoptosis of the cells was determined by flow cytometry (FC) after JNK over-expression.
 Results: FC results showed that the number of apoptotic hepatocytes increased after JNK overexpression in hepatocytes while TUNEL assay results demonstrated that hepatocyte apoptosis increased in CPB group, when compared to control group; furthermore, the number of apoptotic cells gradually increased within 6 h after surgery. The expressions of JNK and p-c-Jun were higher in CPB group than in control group, and increased gradually in both groups within 6 h after surgery. Overexpression of JNK decreased the proliferation of hepatocytes, and also lowered protein expression levels of p-c-Jun and Bim; on the other hand, the protein expression levels of Bcl-2 fell, while mRNA expression levels of caspase-3 and caspase-9 mRNA increased.
 Conclusion: JNK pathway promotes hepatocyte apoptosis after cardiopulmonary bypass by inhibiting Bcl-2 pathway and promoting the expressions of Bim caspase-3 and caspase-9.
 Keywords: Cardiopulmonary bypass, Apoptosis, JNK pathway, Bim, caspase-3 and caspase-9
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42

Vycital, Miroslav, and Cenek Jarský. "An automated nD model creation on BIM models." Organization, Technology and Management in Construction: an International Journal 12, no. 1 (2020): 2218–31. http://dx.doi.org/10.2478/otmcj-2020-0018.

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AbstractThe construction technology (CONTEC) method was originally developed for automated CONTEC planning and project management based on the data in the form of a budget or bill of quantities. This article outlines a new approach in an automated creation of the discrete nD building information modeling (BIM) models by using data from the BIM model and their processing by existing CONTEC method through the CONTEC software. This article outlines the discrete modeling approach on BIM models as one of the applicable approaches for nD modeling. It also defines the methodology of interlinking BIM model data and CONTEC software through the classification of items. The interlink enables automation in the production of discrete nD BIM model data, such as schedule (4D) including work distribution end resource planning, budget (5D)—based on integrated pricing system, but also nD data such as health and safety risks (6D) plans (H&S Risk register), quality plans, and quality assurance checklists (7D) including their monitoring and environmental plans (8D). The methodology of the direct application of the selected classification system, as well as means of data transfer and conditions of data transferability, is described. The method was tested on the case study of an office building project, and acquired data were compared to actual construction time and costs. The case study proves the application of the CONTEC method as a usable method in the BIM model environment, enabling the creation of not only 4D, 5D models but also nD discrete models up to 8D models in the perception of the construction management process. In comparison with the existing BIM classification systems, further development of the method will enable full automated discrete nD model creation in the BIM model environment.
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43

Carvalho, J. P., K. Ridder, L. Bragança, and R. Mateus. "Using BIM to optimise and assess the energy efficiency category of SBToolPT-H." IOP Conference Series: Earth and Environmental Science 225 (February 24, 2019): 012072. http://dx.doi.org/10.1088/1755-1315/225/1/012072.

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44

Biancardo, Salvatore Antonio. "Heritage BIM Approach for roman pavements." European Transport/Trasporti Europei, no. 91 (February 2023): 1–10. http://dx.doi.org/10.48295/et.2023.91.8.

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The growing necessity to design and digitally representation of historical pavements has led the specialists to use different Building Information Modelling (BIM) tools to control the road design and construction phases. In this research paper, a Heritage BIM (H-BIM) approach was developed to recreate an archaeological road to accomplish the disruption analysis of stone pavements. In detail, within Autodesk Infraworks the conceptual model of the road and the digital terrain model (DTM) was generated; then the road corridor design process was performed within Autodesk Civil 3D using a parametric road section which was created by means of Subassembly composer, a Civil 3D extension. Subsequently, a visual programming application, Dynamo, based on Python language, was adopted to extract and update corridor information. In detail, a workflow was developed to implement a disruption analysis of road stone pavements and the output of the calculation were inserted in the model. As preliminary results, a tool is proposed to support the authorities and experts during the managing processes.
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45

Yıldırım, M. Hakkı, Zerrin Heren, Hümeyra Paşaoğlu, Derya Hıra та Orhan Büyükgüngör. "Bis(benzimidazole-κN3)bis(2-benzoylbenzoato-κO)copper(II)". Acta Crystallographica Section E Structure Reports Online 65, № 6 (2009): m638—m639. http://dx.doi.org/10.1107/s1600536809017139.

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In the title centrosymmetric mononuclear copper(II) compound, [Cu(C14H9O3)2(C7H6N2)2], the central CuIIion is coordinated by two N atoms from two symmetry-related benzimidazole (bim) ligands and two O atoms from two symmetry-related 2-benzoylbenzoate (2-byba) ligands in a square-planar geometry. The molecules are linked into chains running along thebaxis by N—H...O hydrogen bonds and the chains are cross-linked by C—H...π interactions.
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46

Noia, Paula Regina da Cruz. "Subsídios para implementação de H-BIM na Gestão de Facilidades no Edifício Vilanova Artigas da FAU USP." Gestão & Tecnologia de Projetos 17, no. 2 (2022): 195–210. http://dx.doi.org/10.11606/gtp.v17i2.174789.

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O presente artigo representa um trabalho inicial que contextualiza as recentes intervenções espaciais do Edifício Vilanova Artigas, circunstancia os recentes esforços visando a conservação de seu patrimônio edificado, analisa as dinâmicas atuais das partes interessadas nos processos de gestão dos espaços físicos e consequentemente os de gestão de facilidades do edifício sede da Faculdade de Arquitetura e Urbanismo da Universidade de São Paulo (FAU - USP). Tal primeira etapa de investigação visa fomentar subsídios para a compreensão dos procedimentos internos de gestão e alavancar a implementação do H-BIM, propondo assim o aprimoramento das praticas atuais e a preservação do patrimônio arquitetônico. Através de uma metodologia com abordagem qualitativa centrada no estudo de caso, a pesquisa elabora uma observação circunstanciada das ações recentes de gestão dos espaços físicos do edifício objeto de estudo. Pautada em fontes primarias de dados pertencentes à FAU e à USP (arquivos do SVInfra, documentos do sistema Proteos USP, relatórios de atividades SVInfra 2014-2020, ordens de serviços no sistema Help Desk do SVInfra 2014-2020 entre outros) o trabalho levanta nas imprecisões das praticas atuais possibilidades para a incursão da tecnologia H-BIM como ferramenta de gerenciamento de ciclo de vida do edifício. Acredita-se assim que que a implementação do H-BIM pode ser uma ferramenta que facilitará a integração dos trabalhos teóricos, desenvolvidos no âmbito de pesquisa da Faculdade de Arquitetura e Urbanismo da FAU USP e a atuação pratica do Serviço Técnico de Infraestrutura, através da gestão da informação. Resultaria assim em uma importante contribuição para a preservação do patrimônio histórico, bem como uma melhor utilização dos recursos físico-financeiros da esfera publica.
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Chen, Xingwang, Xueyuan Shen, Jianbo Lai, et al. "Influence of Melatonin on Behavioral and Neurological Function of Rats with Focal Cerebral Ischemia-Reperfusion Injury via the JNK/FoxO3a/Bim Pathway." Computational and Mathematical Methods in Medicine 2022 (January 17, 2022): 1–12. http://dx.doi.org/10.1155/2022/8202975.

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Objective. To investigate the influence of melatonin on behavioral and neurological function of rats with focal cerebral ischemia-reperfusion injury via the JNK/FoxO3a/Bim pathway. Methods. One hundred and twenty healthy male SD rats were randomized into the model group (Model: the middle cerebral artery occlusion (MCAO) model was constructed and received an equal volume of normal saline containing 5% DMSO), sham operation group (Sham: received no treatment except normal feeding), and low, medium, and high dose of melatonin group (L-MT, M-MT, and H-MT intraperitoneally injected 10, 20, and 40 mg/kg melatonin 30 min after IR, respectively), with 24 rats in each group. Following 24 h of reperfusion, the rats in each of the above groups were tested for neurological deficit symptoms and behavioral changes to screen the rats included in the study. HE and TUNEL stainings were performed to observe pathological changes. Levels of oxidative stress-related indexes, inflammatory factor-related indexes, nuclear factor-κB p65 (NF-κB p65), and interferon-γ (IFN-γ) in the rat brain were measured by ELISA. The JNK/FoxO3a/Bim pathway-related proteins as well as Bcl-2, Caspase-3, and Bax were examined using Western blot. Results. Detection of behavioral indicators showed that the MACO model was successfully constructed in rats. L-MT, M-MT, and L-MT groups presented reduced malondialdehyde (MDA), reactive oxygen species (ROS), tumor necrosis factor- (TNF-) α, interleukin- (IL-) 6, IL-1β, IFN-γ, NF-κB p65, and apoptosis compared with the Model group ( P < 0.05 ), and the improvement degree was better in the M-MT group versus the L-HT group. Bcl-2 protein expression in the brain tissue of L-MT, M-MT, and H-MT groups increased significantly, while Bax, Caspase-3, p-JNK, p-FoxO3a, and Bim protein expression declined markedly, versus the Model group ( P < 0.05 ). The changes of indexes were greater in the M-MT group compared with that in the L-MT group. No significant difference was observed in all the above indexes between the M-MT group and the H-MT group ( P > 0.05 ). Conclusions. In the MACO rat model, melatonin can effectively reduce Bax and Caspase-3 levels by modulating the JNK/FoxO3a/Bim pathway, inhibit neuronal apoptosis, and alleviate neurological deficits by reducing the release of proinflammatory mediators, with anti-inflammatory and antioxidant effects. In addition, 20 mg/kg is the optimal melatonin concentration.
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48

Tang, Yu-Huan, Fei Wang, and Jian Zhang. "Construction of unprecedented pillar-layered metal organic frameworks via a dual-ligand strategy for dye degradation." Dalton Transactions 47, no. 12 (2018): 4032–35. http://dx.doi.org/10.1039/c7dt04484d.

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Presented here are two new pillar-layered MOFs based on different metal–carboxylate SBUs employed by mixing D-H<sub>2</sub>Cam and OH-bim ligands. The Zn/Co mixed compound 2 exhibits an adjustable Zn/Co ratio, which reversibly results in an adjustable photocatalytical property of dye degradation.
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49

Gozal, Evelyne, Anisha L. Roussel, Gregory A. Holt, et al. "Protein kinase C modulation of ventilatory response to hypoxia in nucleus tractus solitarii of conscious rats." Journal of Applied Physiology 84, no. 6 (1998): 1982–90. http://dx.doi.org/10.1152/jappl.1998.84.6.1982.

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This study aimed to determine the role of protein kinase C (PKC) in signal transduction mechanisms underlying ventilatory regulation in the nucleus tractus solitarii (NTS). Microinjection of phorbol 12-myristate 13-acetate into the commissural NTS of nine chronically instrumented, unrestrained rats elicited significant cardiorespiratory enhancements that lasted for at least 4 h, whereas administration of vehicle ( n = 15) or the inactive phorbol ester 4α-phorbol 12,13-didecanoate ( n = 7) did not elicit minute ventilation (V˙e) changes. Peak hypoxic V˙eresponses (10% O2-balance N2) were measured in 19 additional animals after NTS microinjection of bisindolylmaleimide (BIM) I, a selective PKC inhibitor ( n= 12), BIM V (inactive analog; n = 7), or vehicle (Con; n = 19). In Con,V˙e increased from 139 ± 9 to 285 ± 26 ml/min in room air and hypoxia, respectively, and similar responses occurred after BIM V. BIM I did not affect room airV˙e but markedly attenuated hypoxia-induced V˙e increases (128 ± 12 to 167 ± 18 ml/min; P &lt; 0.02 vs. Con and BIM V). When BIM I was microinjected into the cerebellum ( n = 4), cortex ( n = 4), or spinal cord ( n = 4),V˙e responses were similar to Con. Western blots of subcellular fractions of dorsocaudal brain stem lysates revealed translocation of PKCα, β, γ, δ, ε, and ι isoenzymes during acute hypoxia, and enhanced overall PKC activity was confirmed in the particulate fraction of dorsocaudal brain stem lysates harvested after acute hypoxia. These studies suggest that, in the adult rat, PKC activation in the NTS mediates essential components of the acute hypoxic ventilatory response.
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50

Scandurra, S., and A. di Luggo. "BSDD TO DOCUMENT STATE OF PRESERVATION OF ARCHITECTURAL HERITAGE IN OPEN-HBIM SYSTEMS." International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLVIII-M-2-2023 (June 26, 2023): 1427–34. http://dx.doi.org/10.5194/isprs-archives-xlviii-m-2-2023-1427-2023.

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Abstract. This research explores the possibility of structuring an OpenBIM process useful to work in the BIM ecosystem also for cultural heritage and historical architecture, independent of any specific software and overcoming the difficulties arising from the unique characteristics of these artefacts. The main focus of this work is the use of bSDD as a methodology to add specific information on state of preservation of surfaces and materials directly to BIM models, making it shareable and readable in any IFC viewer.The complexity of historical architecture and the importance of information about its conservation status, puts higher requirements on the level of development of (H)BIM models and its possibility to realize a better interoperability among multiple disciplines and different software solution.To date, there is still no single, recognised, and accepted solution that allows information on the state of preservation of historical artefacts to be documented in BIM according to shared and open workflows. In this respect, the research proposes an ordered organisation - with the use of bSDD - of all decay information present in thesauri, vocabularies, ontologies and official regulations, making it possible to use it according to a predefined process.The testing operation used as a case study Villa Matarazzo, a historic house located in Ercolano (Naples, Italy).
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