Relevant bibliographies by topics / H.M. Hauschild GmbH

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Academic literature on the topic 'H.M. Hauschild GmbH'

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Published: 4 June 2021
Last updated: 9 February 2022

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Journal articles on the topic "H.M. Hauschild GmbH"

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Storch, Volker. "Faszination Meeresforschung. Von Gotthilf Hempel, Irmtraut Hempel, Sigrid Schiel (Hrsg.) und H. M. Hauschild." Biologie in unserer Zeit 37, no. 1 (February 2007): 60–61. http://dx.doi.org/10.1002/biuz.200790016.

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Kietzmann, M. "Environmental Assessment of Products. Volume 2: Scientific Background; M. Hauschild, H. Wenzel (eds.), Chapman & Hall, London, Weinheim, New York, Tokyo, Melbourne, Madras, 1998, XII +565 pp." Toxicon 38, no. 3 (March 2000): 471. http://dx.doi.org/10.1016/s0041-0101(99)00099-9.

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Rubino, Christopher M., Lukas Stulik, Harald Rouha, Zehra Visram, Adriana Badarau, Scott A. Van Wart, Paul G. Ambrose, Matthew M. Goodwin, and Eszter Nagy. "1388. Dose Discrimination for ASN100: Bridging from Rabbit Survival Data to Predicted Activity in Humans Using a Minimal Physiologically Based Pharmacokinetic (mPBPK) Model." Open Forum Infectious Diseases 5, suppl_1 (November 2018): S426. http://dx.doi.org/10.1093/ofid/ofy210.1219.

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Abstract Background ASN100 is a combination of two co-administered fully human monoclonal antibodies (mAbs), ASN-1 and ASN-2, that together neutralize the six cytotoxins critical to S. aureus pneumonia pathogenesis. ASN100 is in development for prevention of S. aureus pneumonia in mechanically ventilated patients. A pharmacometric approach to dose discrimination in humans was taken in order to bridge from dose-ranging, survival studies in rabbits to anticipated human exposures using a mPBPK model derived from data from rabbits (infected and noninfected) and noninfected humans [IDWeek 2017, Poster 1849]. Survival in rabbits was assumed to be indicative of a protective effect through ASN100 neutralization of S. aureus toxins. Methods Data from studies in rabbits (placebo through 20 mg/kg single doses of ASN100, four strains representing MRSA and MSSA isolates with different toxin profiles) were pooled with data from a PK and efficacy study in infected rabbits (placebo and 40 mg/kg ASN100) [IDWeek 2017, Poster 1844]. A Cox proportional hazards model was used to relate survival to both strain and mAb exposure. Monte Carlo simulation was then applied to generate ASN100 exposures for simulated patients given a range of ASN100 doses and infection with each strain (n = 500 per scenario) using a mPBPK model. Using the Cox model, the probability of full protection from toxins (i.e., predicted survival) was estimated for each simulated patient. Results Cox models showed that survival in rabbits is dependent on both strain and ASN100 exposure in lung epithelial lining fluid (ELF). At human doses simulated (360–10,000 mg of ASN100), full or substantial protection is expected for all four strains tested. For the most virulent strain tested in the rabbit pneumonia study (a PVL-negative MSSA, Figure 1), the clinical dose of 3,600 mg of ASN100 provides substantially higher predicted effect relative to lower doses, while doses above 3,600 mg are not predicted to provide significant additional protection. Conclusion A pharmacometric approach allowed for the translation of rabbit survival data to infected patients as well as discrimination of potential clinical doses. These results support the ASN100 dose of 3,600 mg currently being evaluated in a Phase 2 S. aureus pneumonia prevention trial. Disclosures C. M. Rubino, Arsanis, Inc.: Research Contractor, Research support. L. Stulik, Arsanis Biosciences GmbH: Employee, Salary. H. Rouha, 3Arsanis Biosciences GmbH: Employee, Salary. Z. Visram, Arsanis Biosciences GmbH: Employee, Salary. A. Badarau, Arsanis Biosciences GmbH: Employee, Salary. S. A. Van Wart, Arsanis, Inc.: Research Contractor, Research support. P. G. Ambrose, Arsanis, Inc.: Research Contractor, Research support. M. M. Goodwin, Arsanis, Inc.: Employee, Salary. E. Nagy, Arsanis Biosciences GmbH: Employee, Salary.
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Hoebarth, Gerald, Susan Kubik, Martin Wolfsegger, John-Philip Lawo, Alfred Weber, Herbert Gritsch, Werner Hoellriegl, et al. "Pharmacokinetics of Baxter’s Longer Acting rFVIII (BAX 855) in Factor VIII Ko Mice, Rats and Cynomolgus Monkeys." Blood 118, no. 21 (November 18, 2011): 4346. http://dx.doi.org/10.1182/blood.v118.21.4346.4346.

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Abstract Abstract 4346 The pharmacokinetic profile of BAX 855, a longer acting PEGylated variant of Baxter’s recombinant FVIII based on the ADVATE™ manufacturing process, was assessed in comparison to ADVATE™ after a single intravenous bolus injection at a target dose of 200 IU/kg BW in mice and rats and 350 IU/kg BW in cynomolgus monkeys. Mean residence time (MRT), terminal half-life (HL), total clearance standardized per kg body mass (Cl), the AUC0-tlast (the area under the concentration vs. time curve from 0 to the last measured time point), the in vivo recovery (IVR) and volume of distribution at steady state (Vss) for FVIII activity (mice and cynomolgus monkey), FVIII antigen (rats) and FVIII-bound PEG were evaluated in all three models. Blood was sampled at baseline and each of the time points after a single intravenous bolus injection of BAX 855 or ADVATE™. A serial sacrifice design was used for the PK in mice. Sixteen FVIII ko mice (B6;129S4-F8tm2Kaz; m/f) for BAX 855 and eight FVIII ko mice for ADVATE™ per time point were bled by cardiac puncture under anesthesia for blood sampling 5 minutes – 48 hours after a single intravenous bolus injection. A single treatment design was used for the single dose PK in Sprague Dawley rats: 8m + 8f for BAX 855 and 4m + 4f for ADVATE™. A single treatment design was also used for the cynomolgus monkeys: 4m + 4f for BAX 855 and 2m + 2f for ADVATE™. Blood samples were drawn from rats and cynomolgus monkeys for citrated plasma (for analysis of baseline FVIII levels) before administration and 5 minutes - 48 hours (rats) and 5 minutes to 96 hours (cynomolgus monkeys) after administration. The citrated plasma samples were analyzed for FVIII activity (chromogenic assay) in mice and cynomolgus monkeys, for FVIII–bound PEG (using a PEG-FVIII ELISA) in all models and FVIII antigen (using a FVIII ELISA) in rats. In all three models a prolongation in MRT of Baxter’s and Nektar’s new BAX 855 compared with ADVATE™ could be demonstrated. FVIII activity analysis showed an increase of MRT in mice from 4.9 to 7.9 hours and in cynomlogus monkeys from 7.5 to 11.5 hours. This prolongation was also reflected in the terminal half-lives (4.3 to 5.9 hours in mice and 5.7 to 9.4 hours in cynomolgus monkeys). According to this prolongation a lower clearance [mL/h/kg] could be observed for BAX 855 than for ADVATE™ (22.1 to 12.2 in mice and 8.1 to 4.9 in monkeys). Similar levels in all PK parameters could be shown when measuring FVIII-bound PEG in all three preclinical models and FVIII antigen analysis in rats. These PK data provide evidence that PEGylation of human rFVIII increases the circulation time. Disclosures: Hoebarth: Baxter Innovations GmbH: Employment. Kubik:Baxter Innovations GmbH: Employment. Wolfsegger:Baxter Innovations GmbH: Employment. Lawo:Baxter Innovations GmbH: Employment. Weber:Baxter Innovations GmbH: Employment. Gritsch:Baxter Innovations GmbH: Employment. Hoellriegl:Baxter Innovations GmbH: Employment. Schiviz:Baxter Innovations GmbH: Employment. Ehrlich:Baxter Innovations GmbH: Employment. Scheiflinger:Baxter Innovations GmbH: Employment. Turecek:Baxter Innovations GmbH: Employment. Schwarz:Baxter BioScience: Employment. Muchitsch:Baxter Innovations GmbH: Employment.
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Editor, Editor. "Book reviews / Boekresensies." STJ | Stellenbosch Theological Journal 1, no. 1 (July 31, 2015): 361. http://dx.doi.org/10.17570/stj.2015.v1n1.br.

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Brümmer, Vincent. <i>Vroom of regsinnig? Teologie in die NG Kerk</i>, 2013, Wellington: Bybel Media, ISBN: 9780864877185<br /> Conradie, Ernst M. <i>Reconciliation - A guiding vision for South Africa?</i>, 2013, Stellenbosch: Sun Press, ISBN: 9781920689087<br /> Conradie, Ernst M. <i>South African perspectives on Notions and Forms of Ecumenicity</i>, 2013, Stellenbosch: Sun Press, ISBN: 9781920689063<br /> Conradie, Ernst M & Klaasen, John. <i>The Quest for Identity in so-called Mainline Churches in South Africa</i>, 2013, Stellenbosch: Sun Press, ISNB: 9781920689223<br /> Conradie, Ernst M. <i>Saving the earth? The legacy of reformed views on “re-creation”</i>, Studies in Religion and Environment, Vol. 8, 2013, Lit Verlag GmbH & Co. KG Wien, ISBN: 9783643903044<br /> Lessing, H, Besten, J, Dedering, T, Hohmann, C and Kriel, L (eds). <i>The German Protestant Church in colonial Southern Africa: The impact of overseas work from the beginnings until the 1920s </i>, 2012, Pietermaritzburg: Cluster, ISBN: 9783447067751
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Hose, Dirk, Anja Seckinger, Hartmut Goldschmidt, Tobias Meißner, Blanka Leber, Kai Neben, Jens Hillengass, et al. "A Novel Class of Sulfonanilides Entering Clinical Trials for Targeted Treatment of Multiple Myeloma: Dual-Mechanism Compounds Inhibiting HIF1A-Signaling and Inducing Apoptosis." Blood 116, no. 21 (November 19, 2010): 2987. http://dx.doi.org/10.1182/blood.v116.21.2987.2987.

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Abstract Abstract 2987 Background. We have recently shown HIF1A to be expressed in 95.4% of CD138-purified myeloma cell samples from previously untreated patients (n= 329), with significantly higher [lower] expression in case of presence of t(4,14) [hyperdiploidy] vs. patients without the respective aberration. This makes HIF1A an interesting target in myeloma treatment. Additionally, we have shown about 40% of myeloma cell samples to have a proliferation-index above the median plus three standard-deviations of normal bone-marrow plasma cells, and we and others have proven proliferation to be associated with adverse prognosis in myeloma. Here, we report on 2 members of a novel class of sulfonanilides, their preclinical activity and pharmacology, and their dual mechanism of action, targeting HIF1A-signaling and inducing apoptosis via cell cycle arrest and tubulin depolymerization. Patients and Methods. The effect of the novel sulfonanilides ELR510444 and ELR510552 on the proliferation of 20 human myeloma cell lines and the survival of 5 primary myeloma cell-samples cultured within their microenvironment were tested. The results of efficacy studies in in two murine models (RPMI8226-xenograft-model and 5T33-model) are also presented. The mechanism of action was investigated using a variety of in-vitro assays (see below). Results. Preclinical activity in Myeloma. i) The sulfonanilides ELR510444 and ELR510552 completely inhibit proliferation of 20/20 tested myeloma cell lines at low nM concentrations and ii) induce apoptosis in 5/5 primary myeloma cell-samples at 6.4 – 32 nM concentration, without major effect on the bone marrow microenvironment. iii) They significantly inhibit tumor growth (xenograft; RPMI8226 mouse model, 6 mg p.o. bid for ELR510444, 15 mg p.o. bid for ELR510552) and bone marrow infiltration (5T33-model; ELR510444, 6 mg/kg p.o. bid × 4d, rest 3d (cycle)). Mechanism of action. Apoptosis induction and G2/M-block. i) Both compounds lead to caspase-3/7 activation and subsequent apoptosis with cellular EC50 values of 50–100 nM. ii) The compounds induce an initial cellular arrest in G2/M and a significant tubulin depolymerizing effect, followed by an increase in a sub-G1 (apoptotic) population after 24h. HIF1A-inhibition. i) Both compounds show a potent inhibition of HIF1A signaling in a cell based reporter assay (HRE-bla HCT-116) at EC50s of 1–25nM, whereas ii) at concentrations of 1 μ M, neither of the compounds shows an effect in assay systems monitoring the JAK/STAT, NFκB, PI3K/AKT/FOXO or Wnt/β-catenin-signaling pathways. iii) Kinase inhibition profiling showed no significant inhibition at 1μ M in two assays assessing 100 (Invitrogen) and 442 (Ambit) kinases, respectively. Pre-clinical pharmacology. Single dose exposure of 25 mg p.o. yields a maximum concentration of 1.1 μ M with a half life time of 3.6 hours (ELR510444) and 2.7 μ M and 6.6 h (ELR510552) in mice, respectively. The compounds are well-tolerated at levels that are significantly above the in vitro EC50 in all myeloma cell lines and primary samples tested. Conclusion. ELR510444 and ELR510552 are very active on all tested myeloma cell lines and primary myeloma cells without major impact on the bone marrow microenvironment, and show activity in two different mouse models. The compounds inhibit HIF1A-signaling and induce apoptosis via cell cycle arrest and tubulin depolymerization. Preclinical pharmacology data show favorable in vivo profiles with exposure levels in mice significantly higher than concentrations required for in vitro activity. Therefore, this novel class of compounds represents a promising weapon in the therapeutic arsenal against multiple myeloma entering a phase I/II trial within the next year. Disclosures: Leber: ELARA Pharmaceuticals GmbH: Employment. Janssen:ELARA Pharmaceuticals GmbH: Employment. Lewis:ELARA Pharmaceuticals GmbH: Employment. Schultes:ELARA Pharmaceuticals GmbH: Employment.
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Meadow, Richard, and Randi Seljåsen. "Dose-Response Tests with Neem Azal-T Against the Cabbage Moth, 1995." Arthropod Management Tests 22, no. 1 (January 1, 1997): 411. http://dx.doi.org/10.1093/amt/22.1.411a.

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Abstract Cabbage plants in pots were inverted and dipped in 1.5 liters of a solution of Neem Azal-T (Trifolio-M GmbH, Germany). Neem Azal-T contains 5% azadirachtin, generally considered the active ingredient in neem extracts. Neem Azal-T was diluted in water at concentrations of 0, 0.25, 0.5, 1, 2, 4, 8 and 16 ppm azadirachtin. Each plant was held in the solution for 60 sees. After dipping, the plants were set in a screened insectary to dry for 3 hours, cabbage moth larvae in the early 2nd instar were placed in net bags, 20 larvae per bag, and the bags were placed over each plant and secured at the base of the stem. The plants were arranged on the concrete insectary floor in a RCB design with 5 replications. The average air temperature during the experiment was 15.5°C. The average day length was 18 h. The experiment lasted 16 days, at which time larval mortality was assessed.
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Raab, B. "Kapillarelektrophorese – Chromatographie. Würzburger Kolloquium 1992. Wissenschaftliche Leitung: H. Engelhardt, F. Lottspeich, E. Reh, H.-J. Schneider und M. Uihlein; bearbeitet von H.-J Schneider, 167 Seiten, zahlreiche Abb. und Tab. GIT Verlag GmbH, Darmstadt 1992. Preis: 68,–DM." Food / Nahrung 37, no. 5 (1993): 514. http://dx.doi.org/10.1002/food.19930370535.

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Jan Spruyt, Bart. "ORTWIN RUDLOFF, Bonae litterae et Lutherus: Texte und Untersuchungen zu den Anfängen der Theologie des Bremer Reformator Jakob Propst, (Hospitium Ecclesiae: Forschungen zur Bremischen Kirchengeschichte, Bd. 14), Bremen, Verlag H. M. Hauschild, 1985, 274 S., DM 68,_." Nederlands Archief voor Kerkgeschiedenis / Dutch Review of Church History 68, no. 2 (1988): 266–70. http://dx.doi.org/10.1163/002820386x01172.

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Edmondson, Jonathan. "W. Trillmich, T. Hauschild, M. Blech, H. G. Niemeyer, A. Nünnerich-Asmus, and U. Kreilinger, Hispania Antiqua: Denkmäler der Römerzeit. Mainz: von Zabern, 1993. Pp. ix + 503, 254 Pls. 185 illus. ISBN 3-8053-1547-3. DM 198." Journal of Roman Studies 86 (November 1996): 224–26. http://dx.doi.org/10.1017/s0075435800057804.

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Books on the topic "H.M. Hauschild GmbH"

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Innovative Antriebe 2018. VDI Verlag, 2018. http://dx.doi.org/10.51202/9783181023341.

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Zukünftiges Mobilitätsverhalten Mobilität 2050 – Selfdriving-eCo-Hyperflyyer, Drahtesel, oder was? . . . . . . . . . . . . . . . . . . .1 K. C. Keller, Aveniture GmbH, Freinsheim Ökobilanzierung Einfluss von Zellbauform und Zellchemie auf die Ökobilanz von batterieelektrischen Fahrzeugen . . . . . . . . . .5 T. Semper, M. Clauß, IAV GmbH, Stollberg; A. Forell, IAV GmbH, Bad Cannstatt Anwendungsfallabhängige CO2 -Bilanzen elektrifizierter Fahrzeugantriebe –Use case driven CO2 footprint of electrified powertrains . . . . . . . . . . . . . . .17 O. Ludwig, J. Muth, M. Gernuks, H. Schröder, T. Löscheter Horst, Volkswagen AG, Wolfsburg Prädiktion der Lebensdauer von Traktionsbatteriesystemen für reale Nutzungsszenarien . . . .33 M. Ufert, Professur für Fahrzeugmechatronik, Technische Universität Dresden; A. Batzdorf, L. Morawietz, IAM GmbH, Dresden Predictive Energy Management Strategies for Hybrid Electric Vehicles: eHorizon for Battery Management System. . . . . 49 M. ...
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SIMVEC – Simulation und Erprobung in der Fahrzeugentwicklung. VDI Verlag, 2018. http://dx.doi.org/10.51202/9783181023334.

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Inhalt Zukünftiges Mobilitätsverhalten Mobilität 2050 – Selfdriving-eCo-Hyperflyyer, Drahtesel, oder was? . . . . . . . . . . . . . . . . . . .1 K. C. Keller, Aveniture GmbH, Freinsheim Ökobilanzierung Einfluss von Zellbauform und Zellchemie auf die Ökobilanz von batterieelektrischen Fahrzeugen . . . . . . .5 T. Semper, M. Clauß, IAV GmbH, Stollberg; A. Forell, IAV GmbH, Bad Cannstatt Anwendungsfallabhängige CO2 -Bilanzen elektrifizierter Fahrzeugantriebe – Use case driven CO2 footprint of electrified powertrains . . . . . . . . . . . . . . . . . . . . . . . . . . 17 O. Ludwig, J. Muth, M. Gernuks, H. Schröder, T. Löscheter Horst, Volkswagen AG, Wolfsburg Prädiktion der Lebensdauer von Traktionsbatteriesystemen für reale Nutzungsszenarien . . . .33 M. Ufert, Professur für Fahrzeugmechatronik, Technische Universität Dresden; A. Batzdorf, L. Morawietz, IAM GmbH, Dresden Predictive Energy Management Strategies for Hybrid Electric Vehicles: eHorizon for Battery Manage...
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Gerüche in der Umwelt 2019. VDI Verlag, 2019. http://dx.doi.org/10.51202/9783181023631.

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Dieser VDI-Bericht ist ausschließlich als PDF-Dokument erschienen! Inhalt Aktuelles zur Geruchsbewertung Erarbeitung einer Geruchsimmissionsrichtlinie für die Bundesländer Steiermark und Salzburg 1 D. Öttl, M. Mandl, Amt der Steiermärkischen Landesregierung, Salzburg, Österreich; H. Moshammer, L. Weitensfelder, Abt. für Umwelthygiene und Umweltmedizin, Medizinische Universität Wien, Österreich Validierung der Bestimmung und Beurteilung der Wahrnehmungsintensität in der Geruchsimmissionsprognose 13 K. Braunmiller, Müller-BBM GmbH, Karlsruhe; B. Zimmermann, Müller-BBM GmbH, Gelsenkirchen; M. Kortner, Müller-BBM GmbH, Linsengericht Rastermessung und Immissionsprognose: vergleichen wir Vergleichbares? 25 L. Bergamin, KBP GmbH, Bern Geruchsemissionswerte und deren Anwendung in Genehmigungsbescheiden Bilanzierung von Geruchsemissionen durch im Modellversuch ermittelte Emissionsfaktoren und Geruchsschwellen, dargestellt an Beispielen in Genehmigungsverfahren (Phenoplast-Verarbeit...
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Zylinderlaufbahn, Kolben, Pleuel. VDI Verlag, 2018. http://dx.doi.org/10.51202/9783181023174.

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Inhalt Plenarvorträge Antriebstrangkonzepte für Nutzfahrzeuge . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1 B. Nielsen, Daimler AG, Stuttgart Tribologie motorischer Spritzschichten unter dem Einfluss regenerativer Kraftstoffe . . . . . . . 7 M. Scherge, H.-J. Winkler, R. Böttcher, M. Dienwiebel, Fraunhofer IWM MikroTribologie Centrum, Karlsruhe Tribologische Systeme Anforderungen an moderne Tribosysteme in Verbrennungsmotoren . . . . . . . . . . . . . . . . . 17 O. Botz, ROWE MINERALÖLWERK GMBH, Worms Untersuchung von Ölverbrauch und Verschleiß bei DEUTZ-Motoren . . . . . . . . . . . . . . . . . .23 T. Hoen, T. Ortjohann, DEUTZ AG, Köln Poster Session Formhonen light – Funktion und Fertigungstechnik . . . . . . . . . . . . . . . . . . . . . . . . . . . . .37 G. Flores, A. Wiens, Gehring Technologies GmbH, Ostfildern Herstellung und Prüfung von laserstrukturierten Haftreibungsflächen . . . . . . . . . . . . . . . .45 T. Machleidt, Gesellschaft für ...
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Automation 2018. VDI Verlag, 2018. http://dx.doi.org/10.51202/9783181023303.

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Inhalt (Auszüge…) Fertigungsautomation – Plant Lifecycle Management Multidimensionale Datenmodellierung und Analyse zur Qualitätssicherung in der Fertigungsautomatisierung . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 B. Lindemann, N. Jazdi, M. Weyrich, Institut für Automatisierungstechnik und Softwaresysteme, Universität Stuttgart, Stuttgart Intelligente Qualitätssicherung und Fehlerursachenanalyse für Spritzgießmaschinen . . . . . . 13 A. Diedrich, J. Eickmeyer, O. Niggemann, Fraunhofer IOSB-INA, Lemgo; R. Preis, Plastikpack GmbH, Steinheim-Bergheim; J. Häfner, Häfner & Krullmann GmbH, Leopoldshöhe Durchgängige Nutzung mechatronischer Anlagenmodelle über den gesamten Lebenszyklus automobiler Produktionsanlagen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 F. Auris, Daimler AG, Ulm; H. Zipper, ifak e.V., Magdeburg; M. Brandl, Algoryx Simulation AB, München; S. Süß, Prof. Dr.-Ing. Christian...
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Kunststoffe in der Medizintechnik 2018. VDI Verlag, 2018. http://dx.doi.org/10.51202/9783182443520.

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Inhalt Trendbericht Medizintechnik: Highlights & Neuentwicklungen Kunststoffbeutel als Primärpackmittel für Pharmazeutika Prof. Dr. H. Hänel, Sanofi-Aventis Deutschland GmbH, Frankfurt/Main 1 3D-Druck als Schlüsseltechnologie in der Anfertigung individueller kieferorthopädischer Apparaturen Dipl.-Ing. R. Paehl, 3M Oral Care Solutions Division, TOP-Service für Lingualtechnik GmbH, Bad Essen 9 Medizintechnik 4.0 in der praktischen Umsetzung Change der Geschäftsmodelle durch Digitalisierung Dr. rer. pol. Dipl. Betriebswirt J. Knese, MBA, KNESE Consulting, Hannover 15 Kunststoffmaschinen und -peripherie 4.0 – Status und Ausblick Prof. Dr.-Ing. R. Schiffers, M.Sc. J. P. Siepmann, Universität Duisburg-Essen 19 Fortschritte in der Prozesstechnik Spritzgießen und Montieren von kleinen Bauteilen wächst zusammen M. Schmidt, ZAHORANSKY Automotion & Molds GmbH, Freiburg 29 Aktuelle Forschungsberichte Herstellung von Standardthermoplast-Silikon-Verbunden im Mehrkomponentenspritz...
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Particle Foam 2018. VDI Verlag, 2018. http://dx.doi.org/10.51202/9783182443537.

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Inhalt Trendbericht Medizintechnik: Highlights & Neuentwicklungen Kunststoffbeutel als Primärpackmittel für Pharmazeutika Prof. Dr. H. Hänel, Sanofi-Aventis Deutschland GmbH, Frankfurt/Main 1 3D-Druck als Schlüsseltechnologie in der Anfertigung individueller kieferorthopädischer Apparaturen Dipl.-Ing. R. Paehl, 3M Oral Care Solutions Division, TOP-Service für Lingualtechnik GmbH, Bad Essen 9 Medizintechnik 4.0 in der praktischen Umsetzung Change der Geschäftsmodelle durch Digitalisierung Dr. rer. pol. Dipl. Betriebswirt J. Knese, MBA, KNESE Consulting, Hannover 15 Kunststoffmaschinen und -peripherie 4.0 – Status und Ausblick Prof. Dr.-Ing. R. Schiffers, M.Sc. J. P. Siepmann, Universität Duisburg-Essen 19 Fortschritte in der Prozesstechnik Spritzgießen und Montieren von kleinen Bauteilen wächst zusammen M. Schmidt, ZAHORANSKY Automotion & Molds GmbH, Freiburg 29 Aktuelle Forschungsberichte Herstellung von Standardthermoplast-Silikon-Verbunden im Mehrkomponentensprit...
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Schwingungen von Windenergieanlagen 2019. VDI Verlag, 2019. http://dx.doi.org/10.51202/9783181023464.

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Dieser VDI-Bericht ist ausschließlich als PDF-Datei erschienen! Sie möchten gerne erfahren, welche Themen auf der 10. VDI-Fachtagung in Bremen präsentiert wurden? Inhalt Eröffnung Erkenntnisse aus digitalisierten Daten von über 3000 Windenergieanlagen im Betrieb 1 B. Hahn, S. Faulstich, Fraunhofer IEE, Kassel BIG DATA Auswertungen und Analysen von Betriebsdaten I Big Data – Smart Data, analytische Datenauswertung von Betriebsdaten 17 W. Holweger, Schaeffler Technologies AG & Co. KG, Herzogenaurach; F. Harzendorf, B. Azzam, CWD RWTH Aachen University, Aachen; J. Fliege, Universität Southampton, Southampton, UK Felderfahrung von Anlagen und Windparks I MSA (Messsystemanalyse) eines back-to-back Getriebeprüfstands 29 T. Jacob (M.Sc.) (VDI), Flender GmbH, Voerde; M. Blomeyer, Flender GmbH, Bocholt Felderfahrung und Ergebnisse aus großen Windparks: Von der Zuverlässigkeits- und CMS-Analyse zur Prognosefähigkeit 41 S. Mtauweg, V. Meimann, MML Solutions GmbH; H. Fritsch, U.
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Wissenstransfer Zerspanung 2019. VDI Verlag, 2019. http://dx.doi.org/10.51202/9783181023624.

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Dieser VDI-Bericht ist ausschließlich als PDF-Dokument erschienen! Inhalt Prozessauslegung und Überwachung Integrierte CAD/CAM Software für Industrie 4.0 1 R. Keiser, SolidCAM, Hörstel Werkzeuge und Verfahren für die wirtschaftliche und innovative Zerspanung VHM-Fräswerkzeuge zum Dynamischen Fräsen – Voraussetzungen und Besonderheiten 11 P. Binder, Walter AG, Tübingen Innovative Konzeptentwicklung für eine effiziente Bohrbearbeitung – Wendeschneidplattenbohrkonzept für Bohrtiefen bis zu 7xD 15 I. Terwey, Sandvik Tooling Deutschland GmbH, Düsseldorf Schneidplatten – geht’s noch kleiner und schneller? 19 K. Brenner, ISCAR Germany GmbH, Ettlingen Hochleistungs-Schneidstoffe und Beschichtungen HiPIMS – Beschichtungen von heute und morgen – HiPIMS – Die PVD-Beschichtungstechnologie von morgen? 31 M. Weigand, CemeCon AG, Würselen Hybride Beschichtungsprozesse für anwendungsbezogene PVD-Schichten 35 H. Frank, F. Barthelmä, H. Joost, GFE – Gesellschaft für Fertig...
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Ventiltrieb und Zylinderkopf 2019. VDI Verlag, 2019. http://dx.doi.org/10.51202/9783181023532.

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Der VDI-Bericht ist ausschließlich als PDF-Dokument erschienen! Inhalt Keynote Neuheitliche Zylinderabschaltstrategien für zukünftige leichte und mittelschwere Dieselmotoren zur Reduktion der Treibhausgas- und Schadstoffemissionen 1 T. Körfer, P. Heuser, FEV Group GmbH, Aachen; H.-J. Schiffgens, Tula Technologies Ventiltrieb Schaltbare Ventiltriebsysteme – von der Hydraulik zur Elektromechanik 25 F. Himsel, T. Werblinski, W. Christgen, Schaeffler Technologies AG & Co. KG, Herzogenaurach Frictional Performance of the fully variable Valve Train UpValve 45 M. Breuer, D. Furtado, K. Grimm, S. Moormann, S. Schmitt, M. Seibel, Pierburg GmbH, Neuss Verbrauchs- und Emissionspotenziale am Ottomotor mittels schneller Luftpfadregelung in konventionellen- und Hybridantriebsträngen durch einen vollvariablen Ventiltrieb 63 D. Wolf, P. Müller, A. Mayer, S. Hardes, P. Traversa, Schaeffler Technologies AG & Co KG, Herzogenaurach Camcon Intelligent Valve Technology – a Powerful Tool f...
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Book chapters on the topic "H.M. Hauschild GmbH"

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"Characterization: M /g.mol = 103000 Polymer Standard Services GmbH, Mainz, Germany Solvent (A): water H O 7732-18-5." In CRC Handbook of Thermodynamic Data of Aqueous Polymer Solutions, 262–64. CRC Press, 2004. http://dx.doi.org/10.1201/9780203998205-106.

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"Characterization: Polyviol 48/20, Wacker Chemie GmbH, Munich, Germany Solvent (A): water H O 7732-18-5 Polymer (C): dextran Characterization: M/g.mol = 280000, M /g.mol = 2200000." In CRC Handbook of Thermodynamic Data of Aqueous Polymer Solutions, 273–74. CRC Press, 2004. http://dx.doi.org/10.1201/9780203998205-112.

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"REFERENCES HONEY, L.F. and J.B. McQUITTY (1976). Dust in the animal environment. Research Bulletin 76-2, 1-66. (2 ACKEMANN, H.H. (1980). Quantitative Untersuchungen liber den bakteri-ellen Keimgehalt des Absetzstaubes in zwei Schweinemaststallen. Dtsch Tierarztl. Wschr. 87, 335-338. (3 LANGE, A., G. MEHLMRN, W. METHLING and V. NEUPARTH (1983). Dynamik der bakteriellen Kontamination des Staubes in Abferkelstallen. In: 5. Int. Leipziger Tierhyg. Symp., Leipzig, Sammelbd. d. Vortr. S. 137-142. (4 HILLIGER, H.G. (1984). Zur Bilanzierung der Bakterienflora in der Stalluft. Zbl. Vet. Med. B,31, 493-504. (5 MARTIN, H. and R.A. WILLOUGHBY (1972). Organic dust, sulfur dioxide, and the respiratory tract of swine. Arch. Environ. Health 25, 158-165. — (6 OWEN, J.E. (1982a). Dust - the problem and possibilities. Farm Bldg. Progress 67, 3-6. (7 CURTIS, ETC. (1983). Environmental management in animal agriculture. Iowa State University Press, Ames, Iowa. (8 PEPYS, I., P.A. IEMKINS, G.M. FESTENSTEIN, P.H. GREGORY, M.E. LASEY and F.A. SKINNER (1963). Farmer's lung: Thermophilic actinomycetes as a source of "farmer's lung hay" antigen. Lancet, 607-611. (9 BUTIKOFFER, E. and A.L. de WECK (1969).Huhnerzuchterlunge. Dtsch. med. Wochenschr. 94, 2627-2631. KOSTERS, J. (198177 Stallstaub kann gefahrlich werden. DGS 33, 292-293. DAY, D.L., W.L. HENSEN and S. ANDERSON (1965). Gases and odors in confinement buildings. Trans. ASAE 8, 118-121. (12 BURNETT, W.E. (1969). Odor transport by particulate matter in high density poultry houses. Poultry Sci. 48, 182-185. (13 WEURMAN, C. (1975). Vergleich zweier Methoden fur die Messung von Ge-riichen. VDI-Bericht 226, 135-139. VDI-Verlag GmbH Dlisseldorf. (14 VAN GEELEN, M. (1983). Stankproblemen bij siachtkuikenhok zijn even-tueel op te lossen. Pluimveehouderij 13, 12-13. (15 CURTIS, S.E., J.G. DRUMMOND, D.J. GRUNLOH, P.B. LYNCH and A.H. JENSEN (1975). Relative and quantitative aspects of aerial bacteria and dust in swine houses. J. Animal Sci. 41, 1512-1520. (16 BRESK, B. and J. STOLPE (1975). "Der EinfluB des Staubes in industrie-maBigen Schweineproduktionsanlagen auf die Lei stung und Gesundheit der Tiere. Monatsh. Veterinarmed. 30, 572-576. (17 HONEY, L.F. and J.B. McQUITTY (1979T. Some physical factors affect­ ing dust concentrations in a pig facility. Can. Agric. Engineering 21, 9-13. (18 MHO , C.A. et al. (1969). Dust production of poultry litter materi­ als. Auburn Univ. Agr. Exp. Sta. Circ. 169. (19 MATTHES, H. (1979). Art und Zusammensetzung der Luftverunreinigungen in der Nutztierhaltung und ihre Wirkung in der Stallumgebung. Dtsch. Tierarztl. Wochenschr. 86, 262-265. MAN, C.,L. CERNEA and T. BUHATEL (1971). Examenal calitativ pulberi-lor din aerul adapsturilor pentru pasari. Lucrari stiintifice, seria medicina veterinara 27^ , 321-329." In Odour Prevention and Control of Organic Sludge and Livestock Farming, 339. CRC Press, 1986. http://dx.doi.org/10.1201/9781482286311-133.

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Conference papers on the topic "H.M. Hauschild GmbH"

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Jakubick, Alexander T., and Manfred Hagen. "Environmental Risk and Costs/Benefits of the WISMUT Remediation." In ASME 2003 9th International Conference on Radioactive Waste Management and Environmental Remediation. ASMEDC, 2003. http://dx.doi.org/10.1115/icem2003-4982.

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The Uranium mining and milling activities in Eastern Germany before reunification produced more than 232 000 t of U. Following reunification, £ 6.6 billion were committed to remediation of the left behind liabilities. The inventory of the liabilities comprises operations areas (37 km2), waste rock dumps (311 M m3), tailings (160 M m3), an open pit (84 M m3) and five large underground mines (1.53 M m3). The specific activities are 0.5 to 1 Bq/g for the waste rock, 10 Bq/g for the tailings, up to 500 Bq/g for the water treatment residues and 0.2 to 1 Bq/g for scrap metal. The remediation of the risk associated with this inventory is carried out by WISMUT GmbH. The legal framework of the remediation is set by the Federal Mining Act, the Atomic Act, the Radiation Protection Ordinance and the Water Resources Management Act. The large number and variety of objects that release contaminants at very different rates require, remedial measures to be planned and optimized in an integral way for each site. The integration is done on the basis of Conceptual Site Models (CSM). The CSM helps to balance among the objects the remedial effort, the allocation of resources and allows to flexibly adapt remedial measures to the site/object-specific conditions while maintaining conceptual consistency and focus on the overall remediation goals without compromising essential details. The remediation necessity of individual objects or areas is investigated, justified and the type of remedial measures selected on the basis of Remedial Investigation/Feasibility Studies (RI/FS). In the RI/FS the calculated individual effective dose to the public caused by the object/area in the nonremediated and remediated state is compared with the reference level of 1 mSv per year. Based on RI/FS contaminated areas are remediated either for unrestricted or for restricted use. Waste rock piles are remediated by covering in situ, by relocation and/or by backfilling into an open pit. Currently, approximately 40,000 tons of waste rock are backfilled into a pit per day. Backfilling follows a geochemically optimized placement procedure. In cases where the remediation object was judged vulnerable, remediation was supported by risk assessment. A probabilistic risk assessment was used to justify the dry remediation of the tailings ponds. Technically, the most challenging part of dry tailings remediation is the stabilization of the soft, under-consolidated slimes having a high excess pore water pressure and very low shear strengths. Because total cleanup and relocation of contaminants are not always feasible, the remediation is commonly done by covering of the contaminated object or area, i.e. by confinement. The covers used are either barrier covers that limit infiltration by having a low permeability layer incorporated or an evaporative cover which maximizes infiltration storage till it is removed by evapotranspiration. The largest sources of contaminant release are the discharges from flooded mines and from dewatering of the tailings ponds. Discharge rates vary from 30 m3/h to 1000 m3/h. Because the contaminants load in the discharging mine water decreases with time causing the conventional water treatment to become uneconomic, various alternative water treatment technologies are tested at WISMUT to identify suitable and cost efficient replacement options. Considerable amounts of contaminated debris and scrap metals arise from decommissioning and demolition of the structures. The aim is to categorize and recycle the uncontaminated portion of the scrap metal. The categorization of the scrap metal into contaminated and uncontaminated is by measuring the beta-count rate in the field. To improve the selectivity of the field monitors, specially prepared standards reflecting the operational history of the metal at the particular site are used to calibrate the instruments. Approximately £ 3.9 billion were invested into the remediation by end of 2002. A rough calculation of the specific costs of WISMUT remediation when using re-assessed total costs turned out to be approximately £ 22.6 per kg of U3O8 produced. Considering that this sum includes the indirect costs, the specific remediation costs appear in an international comparison very reasonable.
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