Journal articles: 'H.M. Hauschild GmbH'

1

Storch, Volker. "Faszination Meeresforschung. Von Gotthilf Hempel, Irmtraut Hempel, Sigrid Schiel (Hrsg.) und H. M. Hauschild." Biologie in unserer Zeit 37, no. 1 (February 2007): 60–61. http://dx.doi.org/10.1002/biuz.200790016.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Kietzmann, M. "Environmental Assessment of Products. Volume 2: Scientific Background; M. Hauschild, H. Wenzel (eds.), Chapman & Hall, London, Weinheim, New York, Tokyo, Melbourne, Madras, 1998, XII +565 pp." Toxicon 38, no. 3 (March 2000): 471. http://dx.doi.org/10.1016/s0041-0101(99)00099-9.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Rubino, Christopher M., Lukas Stulik, Harald Rouha, Zehra Visram, Adriana Badarau, Scott A. Van Wart, Paul G. Ambrose, Matthew M. Goodwin, and Eszter Nagy. "1388. Dose Discrimination for ASN100: Bridging from Rabbit Survival Data to Predicted Activity in Humans Using a Minimal Physiologically Based Pharmacokinetic (mPBPK) Model." Open Forum Infectious Diseases 5, suppl_1 (November 2018): S426. http://dx.doi.org/10.1093/ofid/ofy210.1219.

Full text

Abstract:

Abstract Background ASN100 is a combination of two co-administered fully human monoclonal antibodies (mAbs), ASN-1 and ASN-2, that together neutralize the six cytotoxins critical to S. aureus pneumonia pathogenesis. ASN100 is in development for prevention of S. aureus pneumonia in mechanically ventilated patients. A pharmacometric approach to dose discrimination in humans was taken in order to bridge from dose-ranging, survival studies in rabbits to anticipated human exposures using a mPBPK model derived from data from rabbits (infected and noninfected) and noninfected humans [IDWeek 2017, Poster 1849]. Survival in rabbits was assumed to be indicative of a protective effect through ASN100 neutralization of S. aureus toxins. Methods Data from studies in rabbits (placebo through 20 mg/kg single doses of ASN100, four strains representing MRSA and MSSA isolates with different toxin profiles) were pooled with data from a PK and efficacy study in infected rabbits (placebo and 40 mg/kg ASN100) [IDWeek 2017, Poster 1844]. A Cox proportional hazards model was used to relate survival to both strain and mAb exposure. Monte Carlo simulation was then applied to generate ASN100 exposures for simulated patients given a range of ASN100 doses and infection with each strain (n = 500 per scenario) using a mPBPK model. Using the Cox model, the probability of full protection from toxins (i.e., predicted survival) was estimated for each simulated patient. Results Cox models showed that survival in rabbits is dependent on both strain and ASN100 exposure in lung epithelial lining fluid (ELF). At human doses simulated (360–10,000 mg of ASN100), full or substantial protection is expected for all four strains tested. For the most virulent strain tested in the rabbit pneumonia study (a PVL-negative MSSA, Figure 1), the clinical dose of 3,600 mg of ASN100 provides substantially higher predicted effect relative to lower doses, while doses above 3,600 mg are not predicted to provide significant additional protection. Conclusion A pharmacometric approach allowed for the translation of rabbit survival data to infected patients as well as discrimination of potential clinical doses. These results support the ASN100 dose of 3,600 mg currently being evaluated in a Phase 2 S. aureus pneumonia prevention trial. Disclosures C. M. Rubino, Arsanis, Inc.: Research Contractor, Research support. L. Stulik, Arsanis Biosciences GmbH: Employee, Salary. H. Rouha, 3Arsanis Biosciences GmbH: Employee, Salary. Z. Visram, Arsanis Biosciences GmbH: Employee, Salary. A. Badarau, Arsanis Biosciences GmbH: Employee, Salary. S. A. Van Wart, Arsanis, Inc.: Research Contractor, Research support. P. G. Ambrose, Arsanis, Inc.: Research Contractor, Research support. M. M. Goodwin, Arsanis, Inc.: Employee, Salary. E. Nagy, Arsanis Biosciences GmbH: Employee, Salary.

APA, Harvard, Vancouver, ISO, and other styles

4

Hoebarth, Gerald, Susan Kubik, Martin Wolfsegger, John-Philip Lawo, Alfred Weber, Herbert Gritsch, Werner Hoellriegl, et al. "Pharmacokinetics of Baxter’s Longer Acting rFVIII (BAX 855) in Factor VIII Ko Mice, Rats and Cynomolgus Monkeys." Blood 118, no. 21 (November 18, 2011): 4346. http://dx.doi.org/10.1182/blood.v118.21.4346.4346.

Full text

Abstract:

Abstract Abstract 4346 The pharmacokinetic profile of BAX 855, a longer acting PEGylated variant of Baxter’s recombinant FVIII based on the ADVATE™ manufacturing process, was assessed in comparison to ADVATE™ after a single intravenous bolus injection at a target dose of 200 IU/kg BW in mice and rats and 350 IU/kg BW in cynomolgus monkeys. Mean residence time (MRT), terminal half-life (HL), total clearance standardized per kg body mass (Cl), the AUC0-tlast (the area under the concentration vs. time curve from 0 to the last measured time point), the in vivo recovery (IVR) and volume of distribution at steady state (Vss) for FVIII activity (mice and cynomolgus monkey), FVIII antigen (rats) and FVIII-bound PEG were evaluated in all three models. Blood was sampled at baseline and each of the time points after a single intravenous bolus injection of BAX 855 or ADVATE™. A serial sacrifice design was used for the PK in mice. Sixteen FVIII ko mice (B6;129S4-F8tm2Kaz; m/f) for BAX 855 and eight FVIII ko mice for ADVATE™ per time point were bled by cardiac puncture under anesthesia for blood sampling 5 minutes – 48 hours after a single intravenous bolus injection. A single treatment design was used for the single dose PK in Sprague Dawley rats: 8m + 8f for BAX 855 and 4m + 4f for ADVATE™. A single treatment design was also used for the cynomolgus monkeys: 4m + 4f for BAX 855 and 2m + 2f for ADVATE™. Blood samples were drawn from rats and cynomolgus monkeys for citrated plasma (for analysis of baseline FVIII levels) before administration and 5 minutes - 48 hours (rats) and 5 minutes to 96 hours (cynomolgus monkeys) after administration. The citrated plasma samples were analyzed for FVIII activity (chromogenic assay) in mice and cynomolgus monkeys, for FVIII–bound PEG (using a PEG-FVIII ELISA) in all models and FVIII antigen (using a FVIII ELISA) in rats. In all three models a prolongation in MRT of Baxter’s and Nektar’s new BAX 855 compared with ADVATE™ could be demonstrated. FVIII activity analysis showed an increase of MRT in mice from 4.9 to 7.9 hours and in cynomlogus monkeys from 7.5 to 11.5 hours. This prolongation was also reflected in the terminal half-lives (4.3 to 5.9 hours in mice and 5.7 to 9.4 hours in cynomolgus monkeys). According to this prolongation a lower clearance [mL/h/kg] could be observed for BAX 855 than for ADVATE™ (22.1 to 12.2 in mice and 8.1 to 4.9 in monkeys). Similar levels in all PK parameters could be shown when measuring FVIII-bound PEG in all three preclinical models and FVIII antigen analysis in rats. These PK data provide evidence that PEGylation of human rFVIII increases the circulation time. Disclosures: Hoebarth: Baxter Innovations GmbH: Employment. Kubik:Baxter Innovations GmbH: Employment. Wolfsegger:Baxter Innovations GmbH: Employment. Lawo:Baxter Innovations GmbH: Employment. Weber:Baxter Innovations GmbH: Employment. Gritsch:Baxter Innovations GmbH: Employment. Hoellriegl:Baxter Innovations GmbH: Employment. Schiviz:Baxter Innovations GmbH: Employment. Ehrlich:Baxter Innovations GmbH: Employment. Scheiflinger:Baxter Innovations GmbH: Employment. Turecek:Baxter Innovations GmbH: Employment. Schwarz:Baxter BioScience: Employment. Muchitsch:Baxter Innovations GmbH: Employment.

APA, Harvard, Vancouver, ISO, and other styles

5

Editor, Editor. "Book reviews / Boekresensies." STJ | Stellenbosch Theological Journal 1, no. 1 (July 31, 2015): 361. http://dx.doi.org/10.17570/stj.2015.v1n1.br.

Full text

Abstract:

Brümmer, Vincent. Vroom of regsinnig? Teologie in die NG Kerk, 2013, Wellington: Bybel Media, ISBN: 9780864877185 Conradie, Ernst M. Reconciliation - A guiding vision for South Africa?, 2013, Stellenbosch: Sun Press, ISBN: 9781920689087 Conradie, Ernst M. South African perspectives on Notions and Forms of Ecumenicity, 2013, Stellenbosch: Sun Press, ISBN: 9781920689063 Conradie, Ernst M & Klaasen, John. The Quest for Identity in so-called Mainline Churches in South Africa, 2013, Stellenbosch: Sun Press, ISNB: 9781920689223 Conradie, Ernst M. Saving the earth? The legacy of reformed views on “re-creation”, Studies in Religion and Environment, Vol. 8, 2013, Lit Verlag GmbH & Co. KG Wien, ISBN: 9783643903044 Lessing, H, Besten, J, Dedering, T, Hohmann, C and Kriel, L (eds). The German Protestant Church in colonial Southern Africa: The impact of overseas work from the beginnings until the 1920s , 2012, Pietermaritzburg: Cluster, ISBN: 9783447067751

APA, Harvard, Vancouver, ISO, and other styles

6

Hose, Dirk, Anja Seckinger, Hartmut Goldschmidt, Tobias Meißner, Blanka Leber, Kai Neben, Jens Hillengass, et al. "A Novel Class of Sulfonanilides Entering Clinical Trials for Targeted Treatment of Multiple Myeloma: Dual-Mechanism Compounds Inhibiting HIF1A-Signaling and Inducing Apoptosis." Blood 116, no. 21 (November 19, 2010): 2987. http://dx.doi.org/10.1182/blood.v116.21.2987.2987.

Full text

Abstract:

Abstract Abstract 2987 Background. We have recently shown HIF1A to be expressed in 95.4% of CD138-purified myeloma cell samples from previously untreated patients (n= 329), with significantly higher [lower] expression in case of presence of t(4,14) [hyperdiploidy] vs. patients without the respective aberration. This makes HIF1A an interesting target in myeloma treatment. Additionally, we have shown about 40% of myeloma cell samples to have a proliferation-index above the median plus three standard-deviations of normal bone-marrow plasma cells, and we and others have proven proliferation to be associated with adverse prognosis in myeloma. Here, we report on 2 members of a novel class of sulfonanilides, their preclinical activity and pharmacology, and their dual mechanism of action, targeting HIF1A-signaling and inducing apoptosis via cell cycle arrest and tubulin depolymerization. Patients and Methods. The effect of the novel sulfonanilides ELR510444 and ELR510552 on the proliferation of 20 human myeloma cell lines and the survival of 5 primary myeloma cell-samples cultured within their microenvironment were tested. The results of efficacy studies in in two murine models (RPMI8226-xenograft-model and 5T33-model) are also presented. The mechanism of action was investigated using a variety of in-vitro assays (see below). Results. Preclinical activity in Myeloma. i) The sulfonanilides ELR510444 and ELR510552 completely inhibit proliferation of 20/20 tested myeloma cell lines at low nM concentrations and ii) induce apoptosis in 5/5 primary myeloma cell-samples at 6.4 – 32 nM concentration, without major effect on the bone marrow microenvironment. iii) They significantly inhibit tumor growth (xenograft; RPMI8226 mouse model, 6 mg p.o. bid for ELR510444, 15 mg p.o. bid for ELR510552) and bone marrow infiltration (5T33-model; ELR510444, 6 mg/kg p.o. bid × 4d, rest 3d (cycle)). Mechanism of action. Apoptosis induction and G2/M-block. i) Both compounds lead to caspase-3/7 activation and subsequent apoptosis with cellular EC50 values of 50–100 nM. ii) The compounds induce an initial cellular arrest in G2/M and a significant tubulin depolymerizing effect, followed by an increase in a sub-G1 (apoptotic) population after 24h. HIF1A-inhibition. i) Both compounds show a potent inhibition of HIF1A signaling in a cell based reporter assay (HRE-bla HCT-116) at EC50s of 1–25nM, whereas ii) at concentrations of 1 μ M, neither of the compounds shows an effect in assay systems monitoring the JAK/STAT, NFκB, PI3K/AKT/FOXO or Wnt/β-catenin-signaling pathways. iii) Kinase inhibition profiling showed no significant inhibition at 1μ M in two assays assessing 100 (Invitrogen) and 442 (Ambit) kinases, respectively. Pre-clinical pharmacology. Single dose exposure of 25 mg p.o. yields a maximum concentration of 1.1 μ M with a half life time of 3.6 hours (ELR510444) and 2.7 μ M and 6.6 h (ELR510552) in mice, respectively. The compounds are well-tolerated at levels that are significantly above the in vitro EC50 in all myeloma cell lines and primary samples tested. Conclusion. ELR510444 and ELR510552 are very active on all tested myeloma cell lines and primary myeloma cells without major impact on the bone marrow microenvironment, and show activity in two different mouse models. The compounds inhibit HIF1A-signaling and induce apoptosis via cell cycle arrest and tubulin depolymerization. Preclinical pharmacology data show favorable in vivo profiles with exposure levels in mice significantly higher than concentrations required for in vitro activity. Therefore, this novel class of compounds represents a promising weapon in the therapeutic arsenal against multiple myeloma entering a phase I/II trial within the next year. Disclosures: Leber: ELARA Pharmaceuticals GmbH: Employment. Janssen:ELARA Pharmaceuticals GmbH: Employment. Lewis:ELARA Pharmaceuticals GmbH: Employment. Schultes:ELARA Pharmaceuticals GmbH: Employment.

APA, Harvard, Vancouver, ISO, and other styles

7

Meadow, Richard, and Randi Seljåsen. "Dose-Response Tests with Neem Azal-T Against the Cabbage Moth, 1995." Arthropod Management Tests 22, no. 1 (January 1, 1997): 411. http://dx.doi.org/10.1093/amt/22.1.411a.

Full text

Abstract:

Abstract Cabbage plants in pots were inverted and dipped in 1.5 liters of a solution of Neem Azal-T (Trifolio-M GmbH, Germany). Neem Azal-T contains 5% azadirachtin, generally considered the active ingredient in neem extracts. Neem Azal-T was diluted in water at concentrations of 0, 0.25, 0.5, 1, 2, 4, 8 and 16 ppm azadirachtin. Each plant was held in the solution for 60 sees. After dipping, the plants were set in a screened insectary to dry for 3 hours, cabbage moth larvae in the early 2nd instar were placed in net bags, 20 larvae per bag, and the bags were placed over each plant and secured at the base of the stem. The plants were arranged on the concrete insectary floor in a RCB design with 5 replications. The average air temperature during the experiment was 15.5°C. The average day length was 18 h. The experiment lasted 16 days, at which time larval mortality was assessed.

APA, Harvard, Vancouver, ISO, and other styles

8

Raab, B. "Kapillarelektrophorese – Chromatographie. Würzburger Kolloquium 1992. Wissenschaftliche Leitung: H. Engelhardt, F. Lottspeich, E. Reh, H.-J. Schneider und M. Uihlein; bearbeitet von H.-J Schneider, 167 Seiten, zahlreiche Abb. und Tab. GIT Verlag GmbH, Darmstadt 1992. Preis: 68,–DM." Food / Nahrung 37, no. 5 (1993): 514. http://dx.doi.org/10.1002/food.19930370535.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Jan Spruyt, Bart. "ORTWIN RUDLOFF, Bonae litterae et Lutherus: Texte und Untersuchungen zu den Anfängen der Theologie des Bremer Reformator Jakob Propst, (Hospitium Ecclesiae: Forschungen zur Bremischen Kirchengeschichte, Bd. 14), Bremen, Verlag H. M. Hauschild, 1985, 274 S., DM 68,_." Nederlands Archief voor Kerkgeschiedenis / Dutch Review of Church History 68, no. 2 (1988): 266–70. http://dx.doi.org/10.1163/002820386x01172.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Edmondson, Jonathan. "W. Trillmich, T. Hauschild, M. Blech, H. G. Niemeyer, A. Nünnerich-Asmus, and U. Kreilinger, Hispania Antiqua: Denkmäler der Römerzeit. Mainz: von Zabern, 1993. Pp. ix + 503, 254 Pls. 185 illus. ISBN 3-8053-1547-3. DM 198." Journal of Roman Studies 86 (November 1996): 224–26. http://dx.doi.org/10.1017/s0075435800057804.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Edmondson, Jonathan. "W. Trillmich, T. Hauschild, M. Blech, H. G. Niemeyer, A. Nünnerich-Asmus, and U. Kreilinger, Hispania Antiqua: Denkmäler der Römerzeit. Mainz: von Zabern, 1993. Pp. ix + 503, 254 Pls. 185 illus. ISBN 3-8053-1547-3. DM 198." Journal of Roman Studies 86 (November 1996): 224–26. http://dx.doi.org/10.2307/300460.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Smit, Miranda N., Xun Zhou, José L. Landero, Malachy G. Young, and Eduardo Beltranena. "Increasing hybrid rye level substituting wheat grain with or without enzyme on growth performance and carcass traits of growing-finishing barrows and gilts." Translational Animal Science 3, no. 4 (July 1, 2019): 1561–74. http://dx.doi.org/10.1093/tas/txz141.

Full text

Abstract:

Abstract: New European, fall-planted hybrid rye grown in western Canada is more resistant to ergot and fusarium and has lower content of anti-nutritional factors than common rye. We evaluated the effect of feeding increasing hybrid rye level substituting wheat grain and non-starch polysaccharide (NSP) enzyme inclusion in diets fed to growing-finishing pigs raised under western Canadian commercial conditions. In total, 1,008 pigs (~44 kg body weight [BW]) housed in 48 pens by sex, 21 pigs per pen, were fed diets with one of three rye (var. KWS Bono; KWS LOCHOW GMBH) inclusion levels substituting wheat grain: low (L; one-third of wheat replaced), medium (M; two-thirds of wheat replaced), or high (H; most wheat replaced), either without (WO) or with (W) enzyme inclusion (280 units of β-glucanase and 900 units of xylanase per kilogram feed; Endofeed W DC; GNC Bioferm) over four growth phases (Grower 2: d 0 to 22, Grower 3: d 23 to 42, Finisher 1: d 43 to 63, Finisher 2: d 64 to slaughter). Pen BW, feed added, and orts were measured on d 0, 22, 42, 63, 76, 91, and at slaughter weight (130 kg). Warm carcasses were weighed and graded (Destron). BW was not affected by either increasing hybrid rye level substituting wheat grain or enzyme inclusion throughout the trial. For the entire trial (d 0 to 76), pigs fed increasing hybrid rye level substituting wheat grain had decreased (P < 0.050) average daily feed intake (ADFI; L 3.05, M 2.98, H 2.91 kg/d) and average daily weight gain (ADG; L 1.01, M 1.00, H 0.97 kg/d). Enzyme inclusion did not affect ADFI but tended (P = 0.080) to increase ADG (WO 0.98, W 1.00 kg/d). Enzyme inclusion improved (P < 0.050) gain-to-feed ratio only in pigs fed the H rye level. Most carcass traits were not affected by either increasing hybrid rye level substituting wheat grain or enzyme inclusion. Increasing dietary hybrid rye level substituting wheat grain increased (P < 0.001) cost per tonne of feed (L 240.28, M 241.28, H 242.20 Can$/kg), but did not affect feed cost per pig or per kilogram BW gain. Enzyme inclusion increased (P < 0.001) cost per tonne of feed (WO 240.36, W 242.15 Can$/kg), but feed cost per pig (WO 82.14, W 80.44 Can$ per pig) and per kilogram BW gain (WO 0.96, W 0.94 Can$/kg gain) were reduced (P < 0.050). In conclusion, fall-planted hybrid rye can completely replace wheat grain in grower-finisher pig diets without affecting feed efficiency, feed cost per pig or feed cost per kilogram BW gain. Inclusion of NSP enzyme would be recommended for diets including high rye levels to improve feed efficiency and ADG.

APA, Harvard, Vancouver, ISO, and other styles

13

Stepanova, Kristina V., Natalia M. Yakovleva, Alexander N. Kokatev, and Håkan Pettersson. "Структура и свойства нанопористых анодных оксидных пленок на алюминиде титана." Kondensirovannye sredy i mezhfaznye granitsy = Condensed Matter and Interphases 21, no. 1 (March 6, 2019): 135–45. http://dx.doi.org/10.17308/kcmf.2019.21/724.

Full text

Abstract:

Работа посвящена обобщению результатов исследования анодирования алюминида титана (γ-TiAl) во фторсодержащих электролитах. Установлены оптимальные условия анодирования, приводящие к формированию самоорганизованных нанопористых анодных оксидных пленок (АОП) на поверхности образцов, сплава Ti-40 wt. % Al. Показано, что при оптимальных условиях образуются рентгеноаморфные оксидные пленки гетерогенного состава (Al2O3:TiO2 @ 1:1) с размерами пор в диапазоне от 40 до 80 nm. Полученные результаты свидетельствуют о перспективности применения анодного наноструктурирования порошков Ti-40 wt. % Al для получения фотокаталитически активных материалов с расширенным до видимого света спектральным диапазоном поглощения. ЛИТЕРАТУРА Wang Y., Ma X., Li H., Yin S., Sato T. Advanced Catalytic materials - Photocatalysis and Other Current Trends, 2016, vol. 12, pp. 337–357. https://doi.org/10.5772/61864 Hashimoto K., Irie H., Fujishima A. Japanese Journal of Applied Physics, 2005, vol. 44, no. 12, pp. 8269–8285. https://doi.org/10.1143/jjap.44.8269 Uddin Md.T., Engg M. Sc. Dr. Rer. Nat. Technical University of Darmstadt, 2014, 222 p. URL: https://d-nb.info/1061050335/04 (accessed 28.11.2018) Batzill M. Energy Environ. Sci., 2011, vol. 4, pp. 3275–3286. https://doi.org/10.1039/c1ee01577j Marschall R. Funct. Mater., 2014. vol. 24. pp. 2421–2440. https://doi.org/10.1002/adfm.201303214 Ghicov A., Schmuki P. Commun., 2009, pp. 2791–2808. https://doi.org/10.1039/b822726h Li F., Zhao Y., Hao Y., Wang X., Liu R., Zhao D., Chen D. Journal of Hazardous Materials, 2012, vol. 239–240. pp. 118–127. https://doi.org/10.1016/j.jhazmat.2012.08.016 Morris S. M., Horton J. A., Jaroniec M. Mesopor. Mater., 2010, vol. 128, pp. 180–186. https://doi.org/10.1016/j.micromeso.2009.08.018 Ahmed M. A., Abdel-Messih M. F. Journal of Alloys and Compounds, 2011, vol. 509, pp. 2154–2159. https://doi.org/10.1016/j.jallcom.2010.10.172 Pakmehr M., Nourmohammadi A., Ghashang M., Saffar-Teluri A. Journal of Particle Science and Technology, 2015, pp. 31–38. https://doi.org/22104/JPST.2015.76 Pei J., Ma W., Li R., Li Y., Du H. Journal of Chemistry, 2015, pp. 1–7. https://doi.org/10.1155/2015/806568 Il'in, A. A., Kolachev, B. A., Pol'kin, I. S. Titanovye splavy. sostav, struktura, svoistva [Titanium alloys. Composition, structure, properties]. Moscow, VILS-MATI Publ., 2009, 520 p. (in Russ.) Tsuchiya, H., Berger, S., Macak, J.M., Ghicov, A., Schmuki, P. Comm., 2007, vol. 9, pp. 2397–2402. https://doi.org/10.1016/j.elecom.2007.07.013 Berger, S., Tsuchiya, H., Schmuki, P. Mater., 2008, vol. 20, pp. 3245–3247. https://doi.org/10.1021/cm8004024 Stepanova K. V., Yakovleva N. M., Kokatev A. N., Pettersson Kh. zap. PetrGU. Seriya Estestvennye i tekhnicheskie nauki, 2015, vol. 147, no. 2, pp. 81–86. (in Russ.) Stepanova К. V., Yakovleva N. M., Kokatev А. N., Pettersson H. Journal of Surface Investigation. X-ray, Synchrotron and Neutron Techniques, 2016, vol. 10, no. 5, pp. 933– https://doi.org/10.1134/S102745101605013X Stepanova K. V. Diss. kand. tekh. nauk. Petrozavodsk, 2016, 162 p. (in Russ.) Yakovleva N. M., Kokatev A. N., Chupakhina E. A., Stepanova K. V., Yakovlev A. N., Vasil'ev S. G., Shul'ga A. M. Condensed Matter and Interphases, 2016, vol. 18, no. 1, pp. 6− URL: http://www.kcmf.vsu.ru/resources/t_18_1_2016_001.pdf (in Russ.) Kokatev A. N. Diss. kand. tekh. nauk. Petrozavodsk, 2013, 170 p. Savchenko O. I., Yakovleva N. M., Yakovlev A. N., Kokatev A. N., Pettersson Kh. Condensed Matter and Interphases, 2012, vol. 14, no. 2, pp. 243–249. URL: http://www.kcmf.vsu.ru/resources/t_14_2_2012_018.pdf (in Russ.) Canulescu S., Rechendorff K., Borca C.N., Jones N.C., Bordo K., Schou J., Pleth Nielsen L., Hoffmann S. V., Ambat R. Applied Physics Letters, 2014, vol. 104, pp. 121910(1–4). https://doi.org/10.1063/1.4866901 Chen C., Liu J., Liu P., Yu B. Advances in Chemical Engineering and Science, 2011, vol. 1, pp. 9– https://doi.org/10.4236/aces.2011.11002 Rashed M. N., El-Amin A. A. International Journal of Physical Sciences, 2007, vol. 2 (3), pp. 073–081. URL: http://www.academicjournals.org/IJPS (accessed 28.11.2018) Ivanov V. M., Tsepkov M. G., Figurovskaya V. N. Vestnik Moskovskogo universiteta. Seriya 2: Khimiya [Moscow University Chemistry Bulletin], 2010, vol. 65, 6, pp. 370-373. https://link.springer.com/article/10.3103%2FS0027131410060076 Scuderi V., Impellizzeri G., Romano L., Scuderi M., Nicotra G., Bergum K., Irrera A., Svensson B.G., Privitera V. Nanoscale Research Letters, 2014, vol. 9, pp. 458–464. https://doi.org/10.1186/1556-276x-9-458 AbdElmoula M. Dr. Philosophy. Boston, 2011, 275 р. Lee K., Mazare A., Schmuki P. Rev., 2014, vol. 114, pp. 9385–9454. https://doi.org/10.1021/cr500061m Leyens C., Peters M. Titanium and Titanium Alloys. Fundamentals and Applications. Weinheim: WILEY-VCH Verlag GmbH & Co. KGaA, 2003, 532 p.

APA, Harvard, Vancouver, ISO, and other styles

14

Pleimes, Dirk, Vivienne Bunker, Michael Meyer, and Maciej Czajkowski. "Effects of a Novel Orally Bioavailable Small Molecule (Imidazolyl Ethanamide Pentandioic Acid) on Acute Radiation Syndrome." Blood 132, Supplement 1 (November 29, 2018): 5089. http://dx.doi.org/10.1182/blood-2018-99-114490.

Full text

Abstract:

Abstract Introduction Acute radiation syndrome (ARS) develops within 24 hours of exposure to ionizing radiation. Leukocyte growth factors have been used to reduce mortality and mitigate the hematopoietic symptoms of ARS. Three subcutaneously applied radiomitigators G-CSF, Peg-G-CSF and GM-CSF have been approved by the FDA as medical countermeasures but few others are under development. Imidazolyl ethanamide pentandioic acid (IEPA, Myelo001) is a novel small molecule for the treatment of ARS. Preclinical and clinical studies have shown that IEPA applied orally or intraperitoneally was effective in reducing hematopoietic symptoms caused by radiation and chemotherapy. Objective To investigate the effects of IEPA as a radioprotector (prophylactic) and radiomitigator (therapeutic) for ARS and hematopoietic syndrome of ARS (H-ARS). Methods Multiple oral or intraperitoneal administrations of IEPA (25 or 50 mg/kg doses) and radiation levels of 5.8 Gy (estimated LD25/30) and 6.0 Gy (estimated LD50/30) on mortality, body weight and bone marrow cellularity were assessed in a mouse model. 205 C57BL/6 mice were subdivided into 1 unirradiated group, 6 groups exposed to 5.8 Gy, and 2 groups exposed to 6.0 Gy. Prophylactic treatment (25 or 50 mg/kg) was started 3 days before total-body irradiation, while therapeutic treatment (50 mg/kg) was begun 24 h post exposure. The 6 LD25/30 groups consisted of a vehicle control group (VL; 2), twice daily intraperitoneally administered IEPA (ML; 3), orally twice a day (ML; 4) or once a day (ML; 5), G-CSF positive control subcutaneously administered once a day (GL; 6) or in combination with IEPA (M/GL; 7). The 2 LD50/30 groups consisted of a vehicle control group (VH; 8) and a group administered IEPA orally once a day (MH; 9). The experiments assessed mortality using Kaplan-Meier estimator, body weight and bone marrow cellularity over the course of 30 days with prescheduled sacrifices of subgroups on days 7, 14 and 30. Results No significant benefit of prophylactic and therapeutic treatment on survival in the lower (5.8 Gy) irradiation group was detected. Groups ML; 3 and ML; 4 had a dose reduction factor (DFR) < 1 vs VL; 2 whereas ML; 5, GL; 6 and M/GL; 7 had a DRFs > 1. In the high radiation group (6.0 Gy), the Kaplan-Meier estimator revealed an increase in survival (85 %) after therapy compared to controls (56 %). The dose reduction factor in group MH; 9 compared to the controls (VH; 8) was 1.5. The highest protective effect on body weight was observed in the therapeutic regimen (MH; 9) used for 6.0 Gy exposure, which showed a positive effect on days 15, 21 and 30. Therapeutic IEPA treatment mitigated the impact of radiation on bone marrow cellularity. A pronounced effect on peripheral hematology was neither observed in the prophylactic, therapeutic IEPA nor the positive control G-CSF treated groups. Conclusions Different routes of administration and doses of IEPA in the prophylactic groups did not alter ARS symptoms. However, therapeutic treatment in the LD25/30 setting with IEPA and G-CSF, and the LD50/30 setting with IEPA at a dose of 50 mg/kg showed a reduction in mortality and weight loss compared to the controls. Additionally, IEPA treatment mitigated the impact of radiation on bone marrow cellularity. Analysis of peripheral blood did not reveal significant differences across the treatment groups probably due to no optimal time point analysis. Limitations included the small size of the prophylactically treated groups exposed to a low radiation dose. Disclosures Pleimes: Bayer: Consultancy, Equity Ownership; Myelo Therapeutics: Employment, Equity Ownership. Bunker:Myelo Therapeutics: Other: Contract Research via SNBL USA on behalf and in account of Myelo Therapeutics GmbH; SNBL USA: Employment. Meyer:Myelo Therapeutics GmbH: Consultancy. Czajkowski:Myelo Therapeutics GmbH: Employment.

APA, Harvard, Vancouver, ISO, and other styles

15

Zheltikov, Aleksei. "The optics encyclopedia: basic foundations and practical applications, volume 1: A–F. Edited by Th. G. Brown, K. Creath, H. Kogelnik, M. A. Kriss, J. Schmit and M. J. Weber. Wiley-VCH Verlag GmbH & Co. KgaA, Weinheim, 2004. 749 pages." Journal of Raman Spectroscopy 37, no. 4 (2006): 552–53. http://dx.doi.org/10.1002/jrs.1434.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Zheltikov, Aleksei. "The Optics Encyclopedia: basic foundations and practical applications, Volume 4: O–S. Th. G. Brown, K. Creath, H. Kogelnik, M. A. Kriss, J. Schmit and M. J. Weber (eds). Wiley-VCH Verlag GmbH & Co. KgaA, Weinheim, 2004, pp. 749." Journal of Raman Spectroscopy 38, no. 1 (2006): 123–24. http://dx.doi.org/10.1002/jrs.1560.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Schmidt, Martin U., Martin Ermrich, and Robert E. Dinnebier. "Determination of the structure of the violet pigment C22H12Cl2N6O4 from a non-indexed X-ray powder diagram." Acta Crystallographica Section B Structural Science 61, no. 1 (January 19, 2005): 37–45. http://dx.doi.org/10.1107/s010876810402693x.

Full text

Abstract:

The violet pigment methylbenzimidazolonodioxazine, C22H12Cl2N6O4 (systematic name: 6,14-dichloro-3,11-dimethyl-1,3,9,11-tetrahydro-5,13-dioxa-7,15-diazadiimidazo-[4,5-b:4′,5′-m]pentacene-2,10-dione), shows an X-ray powder diagram consisting of only ca 12 broad peaks. Indexing was not possible. The structure was solved by global lattice energy minimizations. The program CRYSCA [Schmidt & Kalkhof (1999), CRYSCA. Clariant GmbH, Pigments Research, Frankfurt am Main, Germany] was used to predict the possible crystal structures in different space groups. By comparing simulated and experimental powder diagrams, the correct structure was identified among the predicted structures. Owing to the low quality of the experimental powder diagram the Rietveld refinements gave no distinctive results and it was difficult to prove the correctness of the crystal structure. Finally, the structure was confirmed to be correct by refining the crystal structure of an isostructural mixed crystal having a better X-ray powder diagram. The compound crystallizes in P\bar 1, Z = 1. The crystal structure consists of a very dense packing of molecules, which are connected by hydrogen bridges of the type N—H...O=C. This packing explains the observed insolubility. The work shows that crystal structures of molecular compounds may be solved by lattice energy minimization from diffraction data of limited quality, even when indexing is not possible.

APA, Harvard, Vancouver, ISO, and other styles

18

Klapa, S., A. Müller, A. Koch, A. Kerstein-Staehle, W. Kaehler, H. Heidecke, S. Schinke, et al. "AB0496 AUTOANTIBODIES TARGETING COMPLEMENT RECEPTORS 3A AND 5A1 ARE DECREASED IN ANCA-ASSOCIATED VASCULITIS AND CORRELATE WITH HIGHER RELAPSE RATE." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 1546.1–1546. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1758.

Full text

Abstract:

Background:Activation of the alternative and final common pathways have been shown in ANCA-associated vasculitis (AAV) (1). Circulating titers of C5a are elevated and correlate with disease activity in AAV. Binding to the corresponding G protein-coupled receptor (GPCR) C5aR1 enhances the influx of neutrophils, leading to ROS generation and severe necrotizing of vascular walls (2). Moreover, subsequent interaction of C5a with C5aR1 may represent a proinflammatory amplification loop (3). Blocking of the receptor is protective in a murine model in AAV (4). In humans, avacopan, a C5aR1-inhibitor showed promising results as glucocorticoid-sparing agent in two randomized phase II and one ongoing phase III clinicals trials in AAV (NCT02994927). Notably, disease-specific anti-GPCR autoantibody (aab) signatures have been found in different autoimmune diseases (5).Objectives:The aim of the present study was to examine whether (patho)physiological anti-C3aR and anti-C5aR1 aabs correlate with clinical findings in AAV, and whether this is linked to the clinical outcome.Methods:Sera and plasma of AAV patients [granulomatosis with polyangiitis (GPA), n=64; microscopic polyangiitis (MPA), n=26; eosinophilic granulomatosis with polyangiitis (EGPA), n=11] were measured by Elisa for circulating autoantibodies against complement receptors C3a (anti-C3aR aab) and C5a (anti-C5aR1 aab) and plasma levels of C3a and C5a. Expression of C3aR and C5aR1 on T-cells was determined using flow cytometry. Clinical data were assessed at the time of serum sampling and during follow-up for 48 monthsResults:GPA displayed low titers of anti-C3aR aab (GPA:5.33±2.54vs. HD:6.47±2.61, P=0.0031). Anti-C5aR1 aab were decreased in AAV, especially in GPA (GPA:1.02±1.07vs. HD:6.63±2.91, P=<0.0001). Plasma levels of C5a and anti-C5aR aab yielded an inverse correlation in AAV (r=-0.6813, P=0.0127). C5aR1 expression was increased on T-cells in GPA (CD4+C5aR1+T-cells: GPA:10.76±2.55%vs. HD:3.44±0.68%, P=0.0021; CD8+C5aR1+T-cells GPA:9.74±2.10%vs.HD:4.11±0.92%, P=0.0198). Reduced titers of anti-C5aR1 aab <0.45U/ml displayed an increased relapse risk for major organ involvement in GPA (HR 12.85, P=0.0014).Conclusion:As potential diagnostic marker, anti-C5aR1 aab titer may additionally be useful to monitor disease activity in AAV.References:[1]Chen M et al.Complement deposition in renal histopathology of patients with ANCA-associated pauci-immune glomerulonephritis.Nephrol Dial Transpl. 2009;24:1247-1252[2]Schreiber A et al.C5a receptor mediates neutrophil activation an ANCA-induced glomerulonephritis.J Am Soc Nephrol. 2009; 20:289-298[3]Lamprecht P et al.: Pathogenetic and clinical aspects of Anti-Neutrophil Cytoplasmic Autoantibody-associated vasculitides.Front Immunol.2018 Apr 9;9-680[4]Xiao H et al.C5a receptor (CD88) blockade protects against MPO-ANCA GN.J Am Soc Nephrol. 2014;25(2):225-31[5]Klapa S et al. Decreased endothelin receptor A autoantibody levels are associated with early ischaemic events in patients with giant-cell arteritis.Ann Rheum Dis2019 Oct;78(19):1443-1444Disclosure of Interests:Sebastian Klapa Grant/research support from: Actelion, Consultant of: Pfizer, Abbvie, Antje Müller: None declared, Andreas Koch: None declared, Anja Kerstein-Staehle: None declared, Wataru Kaehler: None declared, Harald Heidecke Shareholder of: Cell Trend GmbH, Employee of: Cell Trend GmbH, Speakers bureau: Cell Trend GmbH, Susanne Schinke Speakers bureau: Pfizer, Markus Huber-Lang: None declared, Martin Nitschke: None declared, Silke Pitann: None declared, Christian Karsten: None declared, Gabriela Riemekasten Consultant of: Cell Trend GmbH, Janssen, Actelion, Boehringer Ingelheim, Speakers bureau: Actelion, Novartis, Janssen, Roche, GlaxoSmithKline, Boehringer Ingelheim, Pfizer, Peter Lamprecht: None declared

APA, Harvard, Vancouver, ISO, and other styles

19

Berg, H. "Neuartige polarographische Methoden: Monographie Nr. 77 zu “Angewandte Chemie” und “Chemie-Ingenieur-Technik” Von H. Schmidt und M. v. Stackelberg. Verlag Chemie GmbH, Weinheim/Bergstraße 1962. 97 S., 49 Bilder, kart. 15,40 DM." Zeitschrift für Chemie 3, no. 5 (September 2, 2010): 199–200. http://dx.doi.org/10.1002/zfch.19630030522.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Grace, R. H. "Transsphincteric surgery of the rectum. A. Huber, A. H. C. v. Hochstetter and M. Allgower. 275 × 200 mm. Pp. 83 + vi. Illustrated, mostly colour. 1984. Berlin: Springer-Verlag GmbH & Co. DM 124." British Journal of Surgery 72, no. 4 (April 1985): 333. http://dx.doi.org/10.1002/bjs.1800720460.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Zheltikov, Aleksei. "The Optics Encyclopedia: Basic Foundations and Practical Applications, Volume 2: G–L. Th. G. Brown, K. Creath, H. Kogelnik, M. A. Kriss, J. Schmit and M. J. Weber (Eds.). Wiley-VCH Verlag GmbH & Co. KgaA, Winheim, 2004, 749 pages, (five volumes)." Journal of Raman Spectroscopy 37, no. 9 (2006): 954–55. http://dx.doi.org/10.1002/jrs.1525.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Riscal, Sandra Aparecida. "Educação e dever profissional na constituição da subjetividade moderna (Education and professional duty in the constitution of the modern subjectivity)." Revista Eletrônica de Educação 13, no. 2 (May 10, 2019): 367. http://dx.doi.org/10.14244/198271993349.

Full text

Abstract:

This article aims to discuss the role of the professional duty in the constitution of the modern subjectivity, based on the analysis of this theme in the books of Max Weber called Essays on the Sociology of Religion. Weber presents a genealogy of the Western modernity, approaching it from the point of view of its specific rationality through which a subjectivity based on the practical instrumental domain would have been consolidated. According to Weber, the Lutheran Reformation, through asceticism, gave to the labor an ethical-religious dimension and laid the foundations for the modern conception of "professional duty", which extended itself to all domains of the human activity. The concept of work as a vocation, derived from Protestant asceticism, is embodied in the methodical and disciplined dedication to work conceived as an individual destiny. By means of the internalization of a specific form of rationality, to which everyone must passively conform, a process of subjectivation has been established, which imposes an instrumental rationality as a legitimate means of cognitive and practical approach to all worldly processes.As a result, professional duty began to determine the sense and meaning of educational processes, whose main purpose is training for work.ResumoEste artigo tem como objetivo discutir o papel do dever profissional na constituição da subjetividade moderna a partir da análise deste tema nos livros de Max Weber denominados Ensaios sobre a Sociologia das Religiões. Weber apresenta uma genealogia da modernidade ocidental, abordando-a do ponto de vista de sua racionalidade específica por meio da qual teria se consolidado uma subjetividade fundamentada no domínio prático instrumental. Segundo Weber, a Reforma Luterana, por meio da ascese, conferiu ao trabalho uma dimensão ético-religiosa e estabeleceu as bases para a concepção moderna de "dever profissional", que se estendeu para todos os domínios da atividade humana. O conceito de trabalho como vocação, derivado da ascese protestante, consubstancia-se na entrega metódica e disciplinada no trabalho concebido como destino individual. Por meio da internalização de uma forma específica de racionalidade, a que todos devem se conformar passivamente, constituiu-se um processo de subjetivação que impõe uma racionalidade instrumental como um meio legítimo de abordagem cognitiva e prática de todos os processos mundanos. Como decorrência, o dever profissional passou a determinar o sentido e significado dos processos educativos, cuja finalidade precípua é a formação para o trabalho. Keywords: Max Weber, Professional training, Subjectivity, Education.Palavras-chave: Max Weber, Formação profissional, Subjetividade, Educação.ReferencesCARVALHO, A. B. Max Weber - modernidade Ciencia e Educação. Petrópolis: Ed. Vozes, 2005.FLICKINGER, H.-G. Reforma e Secularização:uma interface histórica. Veritas, Porto Alegre, v. 63, n.1, p. 224-234, jan-mar. 2018.FREUND, J. L'imaginaire dans l'épistémologie de Weber, Librairie Droz, 1990. In: FREUND, J. Études sur Max Weber. Paris: Librairie Droz, 1990.FUENTE, Y. R. D. L. La libertad como destino: El sujeto moderno en Max Weber. Madrid: Editorial Biblioteca Nueva, 2001.GARCIA, J. M. G. Las huellas de Fausto. La herencia de Goethe en la sociología de Max Weber. Madrid: Tecnos, 1992.LUTERO, M. Tratado da liberdade Cristã. In: LUTERO, M. Martinho Lutero - Obras selecionadas. São Leolpoldo; Porto Alegre: Sinodal/Concórdia, v. II, 1989.MACHADO, R. O nascimento do trágico: de Schiller a Nietzsche. R.J.: Editor Jorge Zahar, 2006.SCHLUCHTER, W. Religion und Lebensführung: Studien zu Max Webers Religions - und Herrschaftssoziologie. Band II. Frankfurt am Main: Suhrkamp Verlag, 1988.SCHLUCHTER, W. El desencantamiento del mundo - Seis estudios sobre Max Weber. México: Fondo de Cultura Econòmica, 2017.SHLUCHTER, W. Paradoxes of Modernity: culture and conduct in the Theory of Max Weber. Stanford: Stanford University Press, 1996.TENBRUCK, F. H. The Problem of Thematic Unity in the Works of Max Weber. The British Journal of Sociology, London, v. 31 - no. 3, p. 316-351, september, 1980. tradução:M. S. Whimster.VINCENT, G. Les types sociologiques d'éducation selon Max Weber. Revue française de pédagogie -, Lyon, p. 75-82, Juillet-Août - septembre 2009. disponivel em: http://www.jstor.org/stable/41202625, acesso 12/07/2017.WEBER, M. Zwischenbetrachtung. Die Wirtschaftsethik der Weltreligionen. Konfuzianismus und Taoismus (Max Weber Gesamtausgabe - (Max Weber Gesamtausgabe MWG I/19). Tübingen: Mohr Siebeck, 1989. SCHMIDT-GLINZER, Helwig & KOLONKO, P. (Orgs.).WEBER, M. A Ética Protestande e o "Espírito" do Capitalismo. Tradução de José Marcos Mariani de Macedo. São Paulo: Companhia das Letras, 2004.WEBER, M. Wissenschaft als Beruf - in Gesammelte Werke. Berlin: Digitale Bibliothek -Directmedia Publishing GmbH, 2005b.WEBER, M. Die protestantische Ethik und der Geist des Kapitalismus in Gesammelte Aufsätza zur Religions Sociologie. Berlin: Digitale Bibliothek - Directmedia Publishing GmbH, v. I, 2005.

APA, Harvard, Vancouver, ISO, and other styles

23

Panyaboriban, S., N. Songsasen, R. P. Singh, L. Padilla, J. Brown, D. Reed, M. Techakumphu, and B. Pukazhenthi. "120 IMPACT OF SEASON ON SEMINAL CHARACTERISTICS AND SPERM CRYOPRESERVATION IN THE TUFTED DEER (ELAPHODUS CEPHALOPHUS)." Reproduction, Fertility and Development 28, no. 2 (2016): 190. http://dx.doi.org/10.1071/rdv28n2ab120.

Full text

Abstract:

The Tufted deer (Elaphodus cephalophus), a small deer species native to China, is listed as near threatened on the IUCN Red List and >70 animals are managed in North American zoos as a hedge against extinction. In this study, we 1) characterized the seminal traits, 2) assessed the impact of season on ejaculate traits and testosterone level, and 3) examined sperm sensitivity to cryopreservation. Semen (24 ejaculates) were obtained from five males (1–2 ejaculates/male per season) by electro-ejaculation and evaluated for volume, osmolality, pH as well as sperm concentration, motility (%M), forward progression (FP, scale = 0–5) and acrosomal integrity (%AI). Ejaculates were divided into two aliquots and cryopreserved (4% vol/vol glycerol final concentration; 50–200 × 106 sperm mL–1) over liquid nitrogen vapor using Beltsville extender (BF5F; Howard et al. 1986) or Triladyl® (TRIL; Minitüb GmbH, Germany) extender. Sperm motility and %AI were assessed immediately (subjective) upon thawing and following swim-up processing (SU; 30 min) using computer-assisted semen analysis after 1, 2, 3, and 4 h of incubation (37°C). Fecal samples were collected 3–5 times weekly for 2 years and analyzed for testosterone (T) metabolites using enzyme immunoassay as a function of season (autumn, September–November; winter, December–February; spring, March–May; and summer, June–August). Data were analyzed using Proc GLM or ANOVA with Tukey multiple mean comparison. Significance was set at P < 0.05. Male reproductive and semen traits peaked in autumn (volume, 2.0 mL; concentration, 207.6 × 106 mL–1; pH, 7.6; osmolality, 310.8 mOsm; %M, 76%; FP, 3.5; and %AI, 82.3). Mean testicular length and neck girth in autumn were 4.9 and 43.2 cm, respectively. Mean T concentration (~1.23 µg g–1 of dry feces) was higher (P < 0.05) in summer compared with winter (1.07 µg g–1 of dry feces) or spring (1.06 µg g–1 of dry feces). Sperm motility and %AI were lower (P < 0.05) immediately after thawing (BF5F, 34.6 and 34.7%, respectively; and TRIL, 23.1 and 29.1%, respectively) compared with fresh semen (76.9 and 74.6%, respectively). Motility characteristics immediately after SU (computer-assisted semen analysis) were higher (P < 0.05) in BF5F compared with TRIL: %M (56.4 v. 44.9%), progressive motility (42.5 v. 21.9%), %AI (41.2 v. 31.3%), straight-line velocity (68.0 v. 53.2 µm s–1), straightness (85.1 v. 75.1%), and linearity (54.3 v. 45.0%). At the end of 4 h of incubation, sperm %M and FP declined (P > 0.05) in both BF5F and TRIL (47 and 30%, respectively) but the %AI was higher (P < 0.05) in BF5F (32%) than TRIL (21%). Results indicate that tufted deer ejaculates exhibit seasonal variations in reproductive traits and cryopreservation in BF5F better preserves sperm motility and acrosomal membrane integrity compared with TRIL.

APA, Harvard, Vancouver, ISO, and other styles

24

Schubert, K. "Steroide Von L. u. M. Fieser. Übersetzung aus dem Englischen von H. Grünewald. WILEY-VCH Verlag GmbH & Co. KGaA., Weinheim/Bergstr. 1961, 1065 Seiten, 27 Bilder, 70 Tabellen, 1 Beilage, Preis Glw. 85,- DM." Zeitschrift für Chemie 2, no. 10 (September 2, 2010): 319. http://dx.doi.org/10.1002/zfch.19620021023.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Marzejon, Marcin Jarosław, and Małgorzata Jędrzejewska-Szczerska. "The influence of small amount of substances present in tissue on immunosuppressive drug optical spectrum." Photonics Letters of Poland 10, no. 3 (October 1, 2018): 79. http://dx.doi.org/10.4302/plp.v10i3.831.

Full text

Abstract:

In this paper, we describe how commonly present in tissue substances - sodium chloride and glucose - affect the optical spectrum of an immunosuppressive drug (Cyclaid® by Apotex). Prepared samples were investigated using the spectrophotometer in the spectrum range from 250 nm to 1100 nm. The maximum wavelength shift calculated on the basis of measurement results is not bigger than the measurement wavelength step. So, it can be concluded, that the small amount of sodium chloride or glucose does not influence the measurement and it is possible to apply spectrophotometry in a point-of-care sensor of the Cyclaid® by Apotex level. Full Text: PDF ReferencesL. Taylor, C. J. E. Watson, and J. A. Bradley, "Immunosuppressive agents in solid organ transplantation: Mechanisms of action and therapeutic efficacy", Crit. Rev. Oncol. Hematol. 56, 23 (2005). CrossRef C. C. Mok, "Calcineurin inhibitors in systemic lupus erythematosus", Best Pract. Res. Clin. Rheumatol. 31, 429 (2017). CrossRef C. E. M. Griffiths et al., "Striae gravidarum in primiparae", Br. J. Dermatol. 155, 1 (2006). CrossRef F. Stucker and D. Ackermann, "Immunsuppressiva - Wirkungen, Nebenwirkungen und Interaktionen", Ther. Umschau. Rev. thérapeutique, 68 ,679 (2011). CrossRef A. Fahr, "Cyclosporin Clinical Pharmacokinetics", Clin. Pharmacokinet. 24, 472 (1993). CrossRef Cyclosporine – UpToDate, DirectLink P. Strakowska, R. Beutner, M. Gnyba et al., "Electrochemically assisted deposition of hydroxyapatite on Ti6A14V substrates covered by CVD diamond films – coating characterization and first cell biological results", Mater Sci Eng C Mater Biol Appl. 59, 624 (2016). CrossRef M. Gnyba, M. S. Wróbel, K. Karpienko et al., "Combined analysis of whole human blood parameters by Raman spectroscopy and spectral-domain low-coherence interferometry", Proc. SPIE 9537, 95371N (2015). CrossRef M. S. Wróbel, M. Gnyba, R. Urniaz et al., "Detection of propofol concentrations in blood by Raman spectroscopy", Proc. SPIE 9537, 95370Z (2015). CrossRef M. Gnyba, et al., "SAVE TO MY LIBRARY Raman spectroscopic investigation of blood and related materials", Proc. SPIE 9448, 944809 (2015). CrossRef H. S. Cho et al., "High frame-rate intravascular optical frequency-domain imaging in vivo", Biomed. Opt. Express 5, 223 (2013). CrossRef T. A. Valdez et al., "Multi-color reflectance imaging of middle ear pathology in vivo", Anal. Bioanal. Chem. 407, 3277 (2015). CrossRef M. Ali Ansari, S. Alikhani, and E. Mohajerani, "A hybrid imaging method based on diffuse optical tomography and optomechanical method to detect a tumor in the biological phantom", Opt. Commun. 342, 12 (2015). CrossRef M. S. Wróbel et al., "Multi-layered tissue head phantoms for noninvasive optical diagnostics", J. Innov. Opt. Health Sci. 08, 1541005 (2015). CrossRef D. A. Skoog, F. J. Holler, and S. R. Crouch, Principles of instrumental analysis, (Belmont, CA, Thomson Brooks/Cole 2007). CrossRef M. Hof, Basics of Optical Spectroscopy in Handbook of Spectroscopy, (Weinheim , Wiley-VCH Verlag GmbH & Co. KGaA 2005). CrossRef M. Marzejon et al,. "Optical-Spectrometry-Based Method for Immunosuppressant Medicine Level Detection in Aqueous Solutions", Sensors, 18, 2001 (2018). CrossRef UV-9000 Double Beam UV/VIS, http://en.metash.com/ProductShow_172.html CrossRef

APA, Harvard, Vancouver, ISO, and other styles

26

Stinshoff, H., K. Brüning, A. Hanstedt, D. Müller, S. Wilkening, and C. Wrenzycki. "117 EFFECT OF DIFFERENT CRYOPRESERVATION METHODS ON THE QUALITY OF IN VITRO-PRODUCED BOVINE EMBRYOS." Reproduction, Fertility and Development 22, no. 1 (2010): 217. http://dx.doi.org/10.1071/rdv22n1ab117.

Full text

Abstract:

In vitro production (IVP) of bovine embryos has been greatly improved over the last couple of years. However, only one-third of the total number of embryos transferred worldwide are of in vitro origin. The IVP embryos still show remarkable differences compared with their in vivo-derived counterparts (i.e. bovine embryos produced in vitro are more sensitive to cryopreservation). So far, vitrification seems to be the most promising method to cryopreserve in vitro-produced bovine embryos. The aim of this study was to determine the effect of 2 different cryopreservation methods on the quality of in vitro-produced bovine embryos at the molecular level using a sensitive RT-qPCR assay. Bovine blastocysts were produced using abattoir ovaries and a standard protocol for IVP (Wrenzycki et al. 2001). They were randomly vitrified employing PBS plus ethylene glycol and DMSO or cryopreserved using a programmable freezer and 1.5 M ethylene glycol. After thawing, embryos from both groups were cultured for 48 h. After 24 h of culture re-expansion rates were documented, and after 48 h hatching rates were documented. After hatching, blastocysts were stored at -80°C for subsequent RT-qPCR analysis. The following gene transcripts known to play important roles during preimplantation development were analyzed: HSP70, GLUT-1, GLUT-3, E-CAD, ZO-1, DNMT3a, IFNτ, DCII. Re-expansion rates were 74.7% (68/91) and 75.0% (87/116) for vitrified and conventionally cryopreserved blastocysts, and 57.1% (52/91) and 55.2% (64/116) of re-expanded embryos hatched. The relative abundances of HSP70, GLUT-1, and ZO-1 transcripts were significantly affected in both groups of cryopreservation compared with the control group (hatched blastocysts without cryopreservation). Conventional cryopreservation had a significant effect on the amount of GLUT-3, DNMT3a, and IFNτ mRNA, whereas vitrification significantly affected DCII transcripts. E-CAD mRNA expression was similar in all groups of embryos. These results suggest that not only the cryopreservation process itself but also the method used to freeze the embryos had a significant influence on the mRNA expression of developmentally important genes in hatched bovine blastocysts. The support of the H.W. Schaumann Stiftung (Germany) and Gynemed Medizinprodukte GmbH & Co. KG (Germany) is gratefully acknowledged.

APA, Harvard, Vancouver, ISO, and other styles

27

Velazquez, M. A., and H. Niemann. "131 APOPTOSIS AND DEVELOPMENT OF IN VITRO-PRODUCED BOVINE EMBRYOS EXPOSED TO SUPRAPHYSIOLOGICAL CONCENTRATIONS OF INSULIN-LIKE GROWTH FACTOR-1 (IGF-1)." Reproduction, Fertility and Development 21, no. 1 (2009): 165. http://dx.doi.org/10.1071/rdv21n1ab131.

Full text

Abstract:

It has been hypothesized that high non-physiological IGF-1 levels are partially responsible for the recurrent pregnancy loss observed in women with the polycystic ovary syndrome (Eng GS et al. 2007 Diabetes 56, 2228–2234). The aim of this study was to determine the effect of supraphysiological concentrations of IGF-1 on blastocyst production and the occurrence of apoptosis in bovine embryos, which are a good model for human embryo development (Baumann CG et al. 2007 Mol. Reprod. Dev. 74, 1345–1353). COC obtained by slicing from abattoir ovaries were matured (TCM-199, Sigma) for 24 h and fertilized (Fert-TALP) for 18 h (Day 0) in vitro. Two different IGF-1 (Recombinant human IGF-1, R&D Systems GmbH, Wiesbaden, Germany) concentrations (supraphysiological = 1000 ng mL–1 and physiological = 100 ng mL–1) were added to the culture media (Synthetic oviduct fluid/BSA) and compared with a control group (no IGF-1 supplementation). On Day 8, blastocyst rates (22 replicates) were recorded and DNA degradation was detected in blastocyst nuclei using a cell death detection kit (Roche Diagnostics GmbH, Mannheim, Germany) based on the terminal deoxinucleotidyl transferase-mediated dUTP nick end labelling (TUNEL) principle. Embryos (n = 27 [control], n = 29 [both IGF-1 groups]) from 4 replicates were examined by confocal laser scanning microscopy. Data were analyzed by ANOVA and the Fisher exact test using the SigmaStat 2.0 software package (Jandel Scientific, San Rafael, CA). Cleavage was numerically improved by both, 1000 (59.1 ± 1.8) and 100 (58.2 ± 2.8) ng IGF-1 over controls (53.5 ± 2.2), but the differences did not reach statistical significance (P = 0.22). The proportion of hatched blastocysts was enhanced by 100 (5.8 ± 1.0, P = 0.03) and 1000 (5.1 ± 0.7, P = 0.03) ng IGF-1 compared to controls (2.8 ± 0.6). Total blastocyst rate was increased by 100 ng IGF-1 (34.4 ± 1.9, P = 0.02) over controls (28.3 ± 1.7), but not by 1000 ng IGF-1 (29.1 ± 1.6 P = 0.75). The 100 ng IGF-1 group (38.5 ± 3.7) had fewer degenerated embryos (P = 0.01) compared to 1000 ng IGF-1 (49.7 ± 3.3). The proportion of embryos displaying at least one apoptotic cell was greater in the 1000 ng IGF-1 group over controls (96% v. 77% P = 0.04). The number of blastomeres with TUNEL-positive nuclei per embryo was higher in the supraphysiological group (5.5 ± 0.6, P < 0.001) compared with the control (2.3 ± 0.4) and the physiological group (2.5 ± 0.3). There were no significant differences between the control and the 100 ng IGF-1 group in this regard (P = 0.49). In conclusion, supraphysiological concentrations of IGF-1 do not increase blastocyst production but increase levels of apoptosis in bovine embryos produced in vitro. M. A. V. is in the PhD program of the University of Veterinary medicine, Hannover, Germany, and is supported by the German Academic Exchange Service (DAAD)

APA, Harvard, Vancouver, ISO, and other styles

28

Bali Papp, A., and E. Varga. "312 CHEMICAL ACTIVATION OF IN VITRO-MATURED PORCINE OOCYTES." Reproduction, Fertility and Development 18, no. 2 (2006): 263. http://dx.doi.org/10.1071/rdv18n2ab312.

Full text

Abstract:

Parthenogenetic oocyte activation is important for nuclear transfer and for the understanding of cell cycle regulation of oocytes. Several chemical agents, including ethanol, cycloheximide, strontium, cytochalasin B, 6 dimethylaminopurine, CaCl2 and ionophore A23187 can induce mammalian oocyte activation in vitro. The objectives of the present study were: (1) to assess the ability of strontium chloride (S), cytochalasin B (CB), cycloheximide (CX), and 6-dimethylaminopurine (D) to induce activation and parthenogenetic development in porcine oocytes; and (2) to verify whether the combinations of treatments (SB group = strontium combined with cytochalasin; SX group = strontium combined with cycloheximide, and SD group = strontium combined with 6-dimethylaminopurine) improves activation and parthenogenetic development rates. Oocytes from slaughterhouse ovaries were matured in vitro for 42 h at 39�C, in 5% CO2 in air. The basic medium used for oocyte maturation was TCM-199 supplemented with 10% pig follicular fluid, 1.25 mM L-glutamine, 0.9 mM Na-pyruvate, 100 �M cysteamine, 0.1 mg/mL streptomycin sulfate, 10 IU/mL pregnant mare serum gonadotropin (PMSG), and 10 IU/mL hCG (Werfft-Chemie GmbH, Vienna, Austria). Denuded MII oocytes were cultured in activation solution for 5 h. Thereafter the oocytes were cultured in NCSU37 for 6 days. At 48 h and 6 days after activation, oocytes, zygotes were fixed in acetic acid:alcohol (1/3 w/v), then stained with 0.1% (w/v) orcein in 45% (v/v) acetic acid, and evaluated under a phase contrast microscope. Each experiment was repeated four times. All data were analyzed by ANOVA, followed by Duncan's multiple range test (P < 0.05). A total of 2243 oocytes were activated in the different groups. In all groups, more than 45% of the oocytes were activated. No significant difference was observed in activation rate among SD (346/170, 49.13%), SX (302/164, 54.3%), and SB (318/182, 57.23%) groups. The activation rate for CB was significantly higher (P < 0.05) than for D or S (323/192, 59.44 � 6.84%; 366/176, 48.09 � 3.43%; and 319/183, 53.29 � 5.39%, respectively). The blastocyst rate for SX was significantly higher (P < 0.05) than that for D, SD, or SB (8.64 � 8.07%; and 0 � 0%; 0 � 0%; and 1.27 � 2.41%, respectively). In conclusion, this study suggests that chemical activation procedure is the most effective in strontium chloride combined with cycloheximide. The lowest oocyte fragmentation rates were in SX (28.40 � 1.26%) and CX (21.05 � 1.12%). This work was supported by the the Hungarian Scientific T 43131 Research Foundation and the Hungarian Science on Technology Foundation E 14/04.

APA, Harvard, Vancouver, ISO, and other styles

29

Kuznetsov, Vyacheslav A., Petr O. Kushchev, Irina V. Ostankova, Alexander Yu Pulver, Natalia A. Pulver, Stanislav V. Pavlovich, and Rimma A. Poltavtseva. "Modern Approaches to the Medical Use of pH- and Temperature-Sensitive Copolymer Hydrogels (Review)." Kondensirovannye sredy i mezhfaznye granitsy = Condensed Matter and Interphases 22, no. 4 (December 15, 2020): 417–29. http://dx.doi.org/10.17308/kcmf.2020.22/3113.

Full text

Abstract:

This article provides the review of the medical use of pH- and temperature-sensitive polymer hydrogels. Such polymers are characterised by their thermal and pH sensitivity in aqueous solutions at the functioning temperature of living organisms and can react to the slightest changes in environmental conditions. Due to these properties, they are called stimuli-sensitive polymers. This response to an external stimulus occurs due to the amphiphilicity (diphilicity) of these (co)polymers. The term hydrogels includes several concepts of macrogels and microgels. Microgels, unlike macrogels, are polymer particles dispersed in a liquid and are nano- or micro-objects. The review presents studies reflecting the main methods of obtainingsuch polymeric materials, including precipitation polymerisation, as the main, simplest, and most accessible method for mini-emulsion polymerisation, microfluidics, and layer-by-layer adsorption of polyelectrolytes. Such systems will undoubtedly be promising for use in biotechnology and medicine due to the fact that they are liquid-swollen particles capable of binding and carrying various low to high molecular weight substances. It is also important that slight heating and cooling or a slight change in the pH of the medium shifts the system from a homogeneous to a heterogeneous state and vice versa. This providesthe opportunity to use these polymers as a means of targeted drug delivery, thereby reducing the negative effect of toxic substances used for treatment on the entire body and directing the action to a specific point. In addition, such polymers can be used to create smart coatings of implanted materials, as well as an artificial matrix for cell and tissue regeneration, contributing to a significant increase in the survival rate and regeneration rate of cells and tissues. References 1. Gisser K. R. C., Geselbracht M. J., Cappellari A.,Hunsberger L., Ellis A. B., Perepezko J., et al. Nickeltitaniummemory metal: A "Smart" material exhibitinga solid-state phase change and superelasticity. Journalof Chemical Education. 1994;71(4): 334. DOI: https://doi.org/10.1021/ed071p3342. Erman B., Flory P.J.. Critical phenomena andtransitions in swollen polymer networks and in linearmacromolecules. Macromolecules. 1986;19(9): 2342–2353. DOI: https://doi.org/10.1021/ma00163a0033. Tanaka T., Fillmore D., Sun S.-T., Nishio I.,Swislow G., Shah A. Phase transitions in ionic gels.Physical Review Letters. 1980;45(20): 1636–1639. DOI:https://doi.org/10.1103/physrevlett.45.16364. Polymer Gels. DeRossi D., Kajiwara K., Osada Y.,Yamauchi A. (eds.). Boston, MA: Springer US; 1991.354 p. DOI: https://doi.org/10.1007/978-1-4684-5892‑35. Ilmain F., Tanaka T., Kokufuta E. Volumetransition in a gel driven by hydrogen bonding. Nature.1991;349(6308): 400–401. DOI: https://doi.org/10.1038/349400a06. Kuhn W., Hargitay B., Katchalsky A., EisenbergH. Reversible dilation and contraction by changing thestate of ionization of high-polymer acid networks.Nature. 1950;165(4196): 514–516. DOI: https://doi.org/10.1038/165514a07. Steinberg I. Z., Oplatka A., Katchalsky A.Mechanochemical engines. Nature. 1966;210(5036):568-571. DOI: https://doi.org/10.1038/210568a08. Tian H., Tang Z., Zhuang X., Chen X., Jing X.Biodegradable synthetic polymers: Preparation,functionalization and biomedical application. Progressin Polymer Science. 2012;37(2): 237–280. DOI: https://doi.org/10.1016/j.progpolymsci.2011.06.0049. Gonçalves C., Pereira P., Gama M. Self-Assembledhydrogel nanoparticles for drug delivery applications.Materials. 2010;3(2): 1420–1460. DOI: https://doi.org/10.3390/ma302142010. Pangburn T. O., Petersen M. A., Waybrant B.,Adil M. M., Kokkoli E. Peptide- and Aptamer-functionalizednanovectors for targeted delivery of therapeutics.Journal of Biomechanical Engineering. 2009;131(7):074005. DOI: https://doi.org/10.1115/1.316076311. Caldorera-Moore M. E., Liechty W. B., PeppasN. A. Responsive theranostic systems: integrationof diagnostic imaging agents and responsive controlledrelease drug delivery carriers. Accounts of ChemicalResearch. 2011;44(10): 1061–1070. DOI: https://doi.org/10.1021/ar200177712. Das M., Sanson N., Fava D., Kumacheva E.Microgels loaded with gold nanorods: photothermallytriggered volume transitions under physiologicalconditions†’. Langmuir. 2007;23(1): 196–201. DOI:https://doi.org/10.1021/la061596s13. Oh J. K., Lee D. I., Park J. M. Biopolymer-basedmicrogels/nanogels for drug delivery applications.Progress in Polymer Science. 2009;34(12): 1261–1282.DOI: https://doi.org/10.1016/j.progpolymsci.2009.08.00114. Oh J. K., Drumright R., Siegwart D. J.,Matyjaszewski K. The development of microgels/nanogels for drug delivery applications. Progress inPolymer Science. 2008;33(4): 448–477. DOI: https://doi.org/10.1016/j.progpolymsci.2008.01.00215. Talelli M., Hennink W. E. Thermosensitivepolymeric micelles for targeted drug delivery.Nanomedicine. 2011;6(7): 1245–1255. DOI: https://doi.org/10.2217/nnm.11.9116. Bromberg L., Temchenko M., Hatton T. A. Smartmicrogel studies. Polyelectrolyte and drug-absorbingproperties of microgels from polyether-modifiedpoly(acrylic acid). Langmuir. 2003;19(21): 8675–8684.DOI: https://doi.org/10.1021/la030187i17. Vinogradov S. V. Polymeric nanogel formulationsof nucleoside analogs. Expert Opinion on Drug Delivery.2007;4(1): 5–17. DOI: https://doi.org/10.1517/17425247.4.1.518. Vinogradov S. V. Colloidal microgels in drugdelivery applications. Current Pharmaceutical Design.2006;12(36): 4703–4712. DOI: https://doi.org/10.2174/13816120677902625419. Kabanov A. V., Vinogradov S. V. Nanogels aspharmaceutical carriers: finite networks of infinitecapabilities. Angewandte Chemie International Edition.2009;48(30): 5418–5429. DOI: https://doi.org/10.1002/anie.20090044120. Lee E. S., Gao Z., Bae Y. H. Recent progress intumor pH targeting nanotechnology. Journal ofControlled Release. 2008;132(3): 164–170. DOI: https://doi.org/10.1016/j.jconrel.2008.05.00321. Dong H., Mantha V., Matyjaszewski K.Thermally responsive PM(EO)2MA magnetic microgelsvia activators generated by electron transfer atomtransfer radical polymerization in miniemulsion.Chemistry of Materials. 2009;21(17): 3965–3972. DOI:https://doi.org/10.1021/cm901143e22. Nayak S., Lyon L. A. Soft nanotechnology withsoft nanoparticles. Angewandte Chemie InternationalEdition. 2005;44(47): 7686–7708. DOI: https://doi.org/10.1002/anie.20050132123. Hennink W. E., van Nostrum C. F. Novelcrosslinking methods to design hydrogels. AdvancedDrug Delivery Reviews. 2012;64: 223–236. DOI: https://doi.org/10.1016/j.addr.2012.09.00924. Motornov M., Roiter Y., Tokarev I., Minko S.Stimuli-responsive nanoparticles, nanogels and capsulesfor integrated multifunctional intelligent systems.Progress in Polymer Science. 2010;35(1-2): 174–211. DOI:https://doi.org/10.1016/j.progpolymsci.2009.10.00425. Saunders B. R., Laajam N., Daly E., Teow S.,Hu X., Stepto R. Microgels: From responsive polymercolloids to biomaterials. Advances in Colloid andInterface Science. 2009;147-148: 251–262. DOI: https://doi.org/10.1016/j.cis.2008.08.00826. Landfester K. Miniemulsion polymerizationand the structure of polymer and hybrid nanoparticles.chemInform. 2009;40(33). DOI: https://doi.org/10.1002/chin.20093327927. Seo M., Nie Z., Xu S., Mok M., Lewis P.C.,Graham R., et al. Continuous microfluidic reactors forpolymer particles. Langmuir. 2005;21(25): 11614–11622. DOI: https://doi.org/10.1021/la050519e28. Nie Z., Li W., Seo M., Xu S., Kumacheva E. Janusand ternary particles generated by microfluidicsynthesis: design, synthesis, and self-assembly. Journalof the American Chemical Society. 2006;128(29): 9408–9412. DOI: https://doi.org/10.1021/ja060882n29. Seiffert S., Thiele J., Abate A. R., Weitz D. A.Smart microgel capsules from macromolecularprecursors. Journal of the American Chemical Society.2010;132(18): 6606–6609. DOI: https://doi.org/10.1021/ja102156h30. Rossow T., Heyman J. A., Ehrlicher A. J.,Langhoff A., Weitz D. A., Haag R., et al. Controlledsynthesis of cell-Laden Microgels by Radical-FreeGelation in Droplet Microfluidics. Journal of theAmerican Chemical Society. 2012;134(10): 4983–4989.DOI: https://doi.org/10.1021/ja300460p31. Perry J. L., Herlihy K. P., Napier M. E.,DeSimone J. M. PRINT: A novel platform toward shapeand size specific nanoparticle theranostics. Accountsof Chemical Research. 2011;44(10): 990–998. DOI:https://doi.org/10.1021/ar200031532. Caruso F., Sukhorukov G. Coated Colloids:Preparation, characterization, assembly and utilization.In: Decher G., Schlenoff J. B., editors. MultilayerThin Films. Weinheim, FRG: Wiley-VCH Verlag GmbH& Co. KGaA; 2002. p. 331-362.33. Sauzedde F., Elaïssari A., Pichot C. Hydrophilicmagnetic polymer latexes. 2. Encapsulation ofadsorbed iron oxide nanoparticles. Colloid & PolymerScience. 1999;277(11): 1041–1050. DOI: https://doi.org/10.1007/s00396005048834. Sauzedde F., Elaïssari A., Pichot C. Hydrophilicmagnetic polymer latexes. 1. Adsorption of magneticiron oxide nanoparticles onto various cationic latexes.Colloid & Polymer Science. 1999;277(9): 846–855. DOI:https://doi.org/10.1007/s00396005046135. Pich A., Richtering W. Microgels by PrecipitationPolymerization: Synthesis, Characterization, andFunctionalization. In: Pich A., Richtering W. (eds.)Chemical Design of Responsive Microgels. SpringerHeidelberg Dordrecht London New York; 2011. p. 1–37.DOI: https://doi.org/10.1007/978-3-642-16379-136. Yamada N., Okano T., Sakai H., Karikusa F.,Sawasaki Y., Sakurai Y. Thermo-responsive polymericsurfaces; control of attachment and detachment ofcultured cells. Die Makromolekulare Chemie, RapidCommunications. 1990;11(11): 571–576. DOI: https://doi.org/10.1002/marc.1990.03011110937. Kushida A., Yamato M., Konno C., Kikuchi A.,Sakurai Y., Okano T. Decrease in culture temperaturereleases monolayer endothelial cell sheets togetherwith deposited fibronectin matrix from temperatureresponsiveculture surfaces. Journal of BiomedicalMaterials Research. 1999;45(4): 355–362. DOI: https://doi.org/10.1002/(sici)1097-4636(19990615)45:4<355::aid-jbm10>3.0.co;2-738. Sekine H., Shimizu T., Dobashi I., Matsuura K.,Hagiwara N., Takahashi M., et al. Cardiac cell sheettransplantation improves damaged heart function viasuperior cell survival in comparison with dissociatedcell injection. Tissue Engineering Part A. 2011;17(23-24): 2973–2980. DOI: https://doi.org/10.1089/ten.tea.2010.065939. Nishida K., Yamato M., Hayashida Y.,Watanabe K., Yamamoto K., Adachi E., et al. Corneal reconstruction with tissue-engineered cell sheetscomposed of autologous oral mucosal epithelium. TheNew England Journal of Medicine. 2004;351(12): 1187–1196. DOI: https://doi.org/10.1056/nejmoa04045540. Kanzaki M., Yamato M., Yang J., Sekine H.,Kohno C., Takagi R., et al. Dynamic sealing of lungair leaks by the transplantation of tissue engineeredcell sheets. Biomaterials. 2007;28(29): 4294–4302.DOI: https://doi.org/10.1016/j.biomaterials.2007.06.00941. Iwata T., Yamato M., Tsuchioka H., Takagi R.,Mukobata S., Washio K., et al. Periodontal regenerationwith multi-layered periodontal ligament-derived cellsheets in a canine model. Biomaterials. 2009;30(14):2716–2723. DOI: https://doi.org/10.1016/j.biomaterials.2009.01.03242. Sawa Y., Miyagawa S., Sakaguchi T., Fujita T.,Matsuyama A., Saito A., et al. Tissue engineeredmyoblast sheets improved cardiac function sufficientlyto discontinue LVAS in a patient with DCM: report ofa case. Surgery Today. 2012;42(2): 181–184. DOI:https://doi.org/10.1007/s00595-011-0106-443. Ohki T., Yamato M., Ota M., Takagi R.,Murakami D., Kondo M., et al. Prevention of esophagealstricture after endoscopic submucosal dissection usingtissue-engineered cell sheets. Gastroenterology.2012;143(3): 582–588. DOI: https://doi.org/10.1053/j.gastro.2012.04.05044. Ebihara G., Sato M., Yamato M., Mitani G.,Kutsuna T., Nagai T., et al. Cartilage repair intransplanted scaffold-free chondrocyte sheets usinga minipig model. Biomaterials. 2012;33(15): 3846–3851. DOI: https://doi.org/10.1016/j.biomaterials.2012.01.05645. Sato M., Yamato M., Hamahashi K., Okano T.,Mochida J. Articular cartilage regeneration using cellsheet technology. The Anatomical Record. 2014;297(1):36–43. DOI: https://doi.org/10.1002/ar.2282946. Kuramoto G., Takagi S., Ishitani K., Shimizu T.,Okano T., Matsui H. Preventive effect of oral mucosalepithelial cell sheets on intrauterine adhesions. HumanReproduction. 2014;30(2): 406–416. DOI: https://doi.org/10.1093/humrep/deu32647. Yamamoto K., Yamato M., Morino T.,Sugiyama H., Takagi R., Yaguchi Y., et al. Middle earmucosal regeneration by tissue-engineered cell sheettransplantation. NPJ Regenerative Medicine. 2017;2(1):6. DOI: https://doi.org/10.1038/s41536-017-0010-748. Gan D., Lyon L. A. Synthesis and Proteinadsorption resistance of PEG-modified poly(Nisopropylacrylamide) core/shell microgels.Macromolecules. 2002;35(26): 9634–9639. DOI: https://doi.org/10.1021/ma021186k49. Veronese F. M., Mero A. The impact ofPEGylation on biological therapies. BioDrugs.2008;22(5): 315–329. DOI: https://doi.org/10.2165/00063030-200822050-0000450. Sahay G., Alakhova D. Y., Kabanov A. V.Endocytosis of nanomedicines. Journal of ControlledRelease. 2010;145(3): 182–195. DOI: https://doi.org/10.1016/j.jconrel.2010.01.03651. Nolan C. M., Reyes C. D., Debord J. D.,García A. J., Lyon L. A. Phase transition behavior,protein adsorption, and cell adhesion resistance ofpoly(ethylene glycol) cross-linked microgel particles.Biomacromolecules. 2005;6(4): 2032–2039. DOI:https://doi.org/10.1021/bm050008752. Scott E. A., Nichols M. D., Cordova L. H., GeorgeB. J., Jun Y.-S., Elbert D. L. Protein adsorption and celladhesion on nanoscale bioactive coatings formed frompoly(ethylene glycol) and albumin microgels.Biomaterials. 2008;29(34): 4481–4493. DOI: https://doi.org/10.1016/j.biomaterials.2008.08.00353. South A. B., Whitmire R. E., García A. J.,Lyon L. A. Centrifugal deposition of microgels for therapid assembly of nonfouling thin films. ACS AppliedMaterials & Interfaces. 2009;1(12): 2747–2754. DOI:https://doi.org/10.1021/am900543554. Wang Q., Uzunoglu E., Wu Y., Libera M. Selfassembledpoly(ethylene glycol)-co-acrylic acidmicrogels to inhibit bacterial colonization of syntheticsurfaces. ACS Applied Materials & Interfaces. 2012;4(5):2498–2506. DOI: https://doi.org/10.1021/am300197m55. Wang Q., Libera M. Microgel-modified surfacesenhance short-term osteoblast response. Colloids andSurfaces B: Biointerfaces. 2014;118: 202–209. DOI:https://doi.org/10.1016/j.colsurfb.2014.04.00256. Tsai H.-Y., Vats K., Yates M. Z., Benoit D. S. W.Two-dimensional patterns of poly(N-isopropylacrylamide)microgels to spatially control fibroblastadhesion and temperature-responsive detachment.Langmuir. 2013;29(39): 12183–12193. DOI: https://doi.org/10.1021/la400971g57. Lynch I. , Miller I. , Gallagher W. M. ,Dawson K. A. Novel method to prepare morphologicallyrich polymeric surfaces for biomedical applicationsvia phase separation and arrest of microgel particles.The Journal of Physical Chemistry B. 2006;110(30):14581–14589. DOI: https://doi.org/10.1021/jp061166a58. Li Y., Chen P., Wang Y., Yan S., Feng X., Du W.,et al. Rapid assembly of heterogeneous 3D cellmicroenvironments in a microgel array. AdvancedMaterials. 2016;28(18): 3543–3548. DOI: https://doi.org/10.1002/adma.20160024759. Bridges A. W., Singh N., Burns K. L., BabenseeJ. E., Andrew Lyon L., García A. J. Reduced acuteinflammatory responses to microgel conformalcoatings. Biomaterials. 2008;29(35): 4605–4615. DOI:https://doi.org/10.1016/j.biomaterials.2008.08.01560. Bridges A. W., Whitmire R. E., Singh N.,Templeman K. L., Babensee J. E., Lyon L. A., et al.Chronic inflammatory responses to microgel-basedimplant coatings. Journal of Biomedical Materials Research Part A. 2010;94A(1): 252–258. DOI: https://doi.org/10.1002/jbm.a.3266961. Gutowski S. M., Templeman K. L., South A. B.,Gaulding J. C., Shoemaker J. T., LaPlaca M. C., et al.Host response to microgel coatings on neuralelectrodes implanted in the brain. Journal of BiomedicalMaterials Research Part A. 2014;102(5): 1486–1499.DOI: https://doi.org/10.1002/jbm.a.3479962. da Silva R. M. P., Mano J. F., Reis R. L. Smartthermoresponsive coatings and surfaces for tissueengineering: switching cell-material boundaries.Trends in Biotechnology. 2007;25(12): 577–583. DOI:https://doi.org/10.1016/j.tibtech.2007.08.01463. Schmidt S., Zeiser M., Hellweg T., Duschl C.,Fery A., Möhwald H. Adhesion and mechanicalproperties of PNIPAM microgel films and theirpotential use as switchable cell culture substrates.Advanced Functional Materials. 2010;20(19): 3235–3243. DOI: https://doi.org/10.1002/adfm.20100073064. Uhlig K., Wegener T., He J., Zeiser M., BookholdJ., Dewald I., et al. Patterned thermoresponsivemicrogel coatings for noninvasive processing ofadherent cells. Biomacromolecules. 2016;17(3): 1110–1116. DOI: https://doi.org/10.1021/acs.biomac.5b01728

APA, Harvard, Vancouver, ISO, and other styles

30

Haenel, H. "Ernährung heute und morgen. Entwicklung — Beratung — Bewertung. Herausgegeben von M. Besch, A. A. Bodenstedt, R. Kibler und H. J. Teuteberg. Schriftenreihe der Arbeitsgemeinschaft Ernährungsverhalten e. V., Bd. 5. 104 Seiten, zahlr. Abb. und Tab. Umschau Verlag Breidenstein GmbH, Frankfurt 1987. Preis: 45,— DM." Food / Nahrung 32, no. 6 (1988): 608. http://dx.doi.org/10.1002/food.19880320625.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Montero-Astúa, M., G. Saborío-R., C. Chacón-Díaz, L. Garita, W. Villalobos, L. Moreira, J. S. Hartung, and C. Rivera. "First Report of Xylella fastidiosa in Avocado in Costa Rica." Plant Disease 92, no. 1 (January 2008): 175. http://dx.doi.org/10.1094/pdis-92-1-0175c.

Full text

Abstract:

Since the late 1990s, chlorotic mottling, marginal scorch, deformation of leaves, defoliation, shortening of internodes, and branch dieback have been observed in avocado trees (Persea americana Mill.) in Costa Rica. The symptoms are not uniformly distributed in the tree, so some branches are symptomatic while others are not. These symptoms are similar to several leaf scorch diseases caused by the bacterium Xylella fastidiosa Wells (2,4). This bacterium has been detected in coffee and citrus plants in Costa Rica. Of 227 avocado trees tested by double-antibody sandwich (DAS)-ELISA with X. fastidiosa specific antiserum (Agdia Inc., Elkhart, IN) from 2000–2004, 188 were positive. Results of ELISA tests of individual trees varied with the season and branches tested. Fifteen greenhouse-grown, ELISA-negative avocado seedlings were grafted with budwood from an ELISA-positive tree. Eight of these developed scorch symptoms and one also showed chlorotic mottling and deformation, showing that the disease is graft transmitted. All of these features are characteristic of diseases caused by X. fastidiosa (2,4). Transmission electron microscopy of leaf petioles from three field trees positive by ELISA, revealed rod-shaped bacilli approximately 1.6 to 2.0 μm long and 0.3 μm in diameter with a rippled cell wall inside xylem vessels and embedded in a matrix; morphology and measurements that are consistent with those reported for X. fastidiosa (2). DNA extraction and PCR attempts have been limited by mucilaginous sap from avocado. Positive PCR results (approximately 472-bp band) were obtained from two of the grafted seedlings and seven field trees from two distinct geographical locations (Alajuela and San José provinces) with DNA extractions from the plant sap using DNeasy Plant Mini Kit (Qiagen GmbH, Hilden, Germany) following a modified protocol (1) and nested PCR (3). Four of the PCR products, including one from the grafted seedlings, were cloned and sequenced in duplicate. GenBank sequences EU021997 to EU022000 present 99 to 100% sequence identity to a Pierce's disease strain from California (Temecula1) and 94 to 95% to a citrus variegated chlorosis strain from Brazil (Found-5). Several attempts have been made to isolate the bacterium in ‘periwinkle wilt’ and buffered cysteine-yeast extract media with negative results, probably because of the rapid production of mucilaginous sap when the avocado tissues were sampled. To our knowledge, this is the first report of X. fastidiosa in avocado trees. References: (1) M. J. Green et al. Plant Dis. 83:482, 1999. (2) S. S. Hearon et al. Can. J. Bot. 58:1986, 1980. (3) M. R. Pooler and J. S. Hartung. Curr. Microbiol. 31:377, 1995. (4) A. H. Purcell et al. Phytopathology 89:53, 1999.

APA, Harvard, Vancouver, ISO, and other styles

32

Kozlowska-Makulska, A., M. S. Szyndel, J. Syller, S. Bouzoubaa, M. Beuve, O. Lemaire, and E. Herrbach. "First Report on the Natural Occurrence of Beet chlorosis virus in Poland." Plant Disease 91, no. 3 (March 2007): 326. http://dx.doi.org/10.1094/pdis-91-3-0326c.

Full text

Abstract:

Yellowing symptoms on sugar beet (Beta vulgaris L.) are caused by several viruses, especially those belonging to the genus Polerovirus of the family Luteoviridae, including Beet mild yellowing virus (BMYV) and Beet western yellows virus (BWYV), and recently, a new species, Beet chlorosis virus (BChV), was reported (2). To identify Polerovirus species occurring in beet crops in Poland and determine their molecular variability, field surveys were performed in the summer and autumn of 2005. Leaves from symptomatic beet plants were collected at 26 localities in the main commercial sugar-beet-growing areas in Poland that included the Bydgoszcz, Kutno, Lublin, Poznań, Olsztyn, and Warszawa regions. Enzyme-linked immunosorbent assay (ELISA) tests (Loewe Biochemica GmbH, Sauerlach, Germany) detected poleroviruses in 23 of 160 samples (approximately 20 samples from each field). Multiplex reverse-transcription polymerase chain reaction (RT-PCR) (1) (GE Healthcare S.A.-Amersham Velizy, France) confirmed the presence of poleroviruses in 13 of 23 samples. Nine of twenty sugar beet plants gave positive reactions with BChV-specific primers and three with primers specific to the BMYV P0 protein. Two isolates reacted only with primer sets CP+/CP, sequences that are highly conserved for all beet poleroviruses. Leaf samples collected from three plants infected with BChV were used as inoculum sources for Myzus persicae in transmission tests to suitable indicator plants including sugar beet, red beet (Beta vulgaris L. var. conditiva Alef.), and Chenopodium capitatum. All C. capitatum and beet plants were successfully infected with BChV after a 48-h acquisition access period and an inoculation access period of 3 days. Transmission was confirmed by the presence of characteristic symptoms and by ELISA. Amino acid sequences obtained from each of four purified (QIAquick PCR Purification kit, Qiagen S.A., Courtaboeuf, France) RT-PCR products (550 and 750 bp for CP and P0, respectively) were 100% identical with the CP region (GenBank Accession No. AAF89621) and 98% identical with the P0 region (GenBank Accession No. NP114360) of the French isolate of BChV. To our knowledge, this is the first report of BChV in Poland. References: (1) S. Hauser et al. J. Virol. Methods 89:11, 2000. (2) M. Stevens et al. Mol. Plant Pathol. 6:1, 2005.

APA, Harvard, Vancouver, ISO, and other styles

33

Shulezhkova, S. G., and O. V. Mikhina. "Bulgarian yesterday, today, tomorrow (to the publication of the book Slawistik. —Band 8: Sprachwissenschaftliche Perspektiven der Bulgaristik: Standpunkte — Innovationen — Herausforderungen der Bulgaristik: Festschrift für Prof. Dr. h. c. Helmut Wilhelm Schaller anlässlich seines 80. Geburtstags / M. Henzelmann (Hg.). — Berlin : Frank & Timme GmbH, 2020. — 342 S.)." Nauchnyi dialog 1, no. 11 (December 7, 2020): 112–31. http://dx.doi.org/10.24224/2227-1295-2020-11-112-131.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Lammers, Roberta Andréia, Letícia Stefenon, and Paula Wietholter. "Aspectos gerais e bucais da Síndrome de Marfan." ARCHIVES OF HEALTH INVESTIGATION 9, no. 5 (October 22, 2020): 498–502. http://dx.doi.org/10.21270/archi.v9i5.4672.

Full text

Abstract:

Introdução: A Síndrome de Marfan é uma desordem genética que afeta o tecido conectivo. No contexto da Odontologia, poucos profissionais da área conhecem os sintomas da síndrome, bem como os cuidados necessários no atendimento ao paciente. Objetivo: O objetivo deste trabalho foi descrever as características anatômicas gerais e bucais de pessoas com Síndrome de Marfan. Material e método: Foram realizadas pesquisas nas bases de dados EBSCO, Bireme e Pubmed entre os anos de 2017 e 2018, sendo utilizados os seguintes descritores: Síndrome de Marfan AND Odontologia AND Manifestações bucais. Resultados: Foram localizados 13 artigos na base de dados BIREME, 23 no PubMed e cinco no EBSCO, totalizando 41 artigos. Desses, 10 foram selecionados para a realização desta pesquisa. As principais alterações gerais descritas na literatura incluem membros superiores e inferiores longos, pé chato, corpo fino com o segmento inferior maior que o segmento superior, aracnodactilia, peito plano com costelas proeminentes e escoliose, pectus carinatum, pectus excavatum, cifose, hiperextensibilidade, dolicostenomelia, alterações oculares e problemas cardíacos. As principais alterações bucais descritas incluem hipoplasia maxilar, retrognatia mandibular, macrostomia, dentição altamente apinhada com mordidas cruzadas anteriores e posteriores, palato de arco alto e relação molar classe II de Angle em ambos os lados e apresentam maior índice de doenças periodontais do que pacientes normais. Conclusões: Os principais cuidados que devem ser observados durante o tratamento odontológico relacionam-se a anamnese e ao exame clínico. O melhor entendimento dessa patologia poderá orientar decisões terapêuticas para prevenção e correção das desordens mencionadas neste trabalho. Descritores: Síndrome de Marfan; Odontologia; Manifestações Bucais. Referências Muñoz Sandoval J, Saldarriaga-Gil W, Isaza de Lourido C. Síndrome de Marfan, mutaciones nuevas y modificadoras del gen FBN1. 2014;27(2):206-15. García JLG, Cedeño LM, Medina JAG. Síndrome de Marfan. Medisan. 2007;11(4):1-5. Pfeiffer MET. Síndrome de Marfan em crianças e adolescentes: importância, critérios e limites para o exercício físico. Rev DERC. 2011;17(3):82-6. Lebreiro A, Martins E, Cruz C, Almeida J, Maciel MJ, Cardoso JC, et al. Síndrome de Marfan: manifestações clínicas, fisiopatologia e novas perspectivas da terapêutica farmacológica. Rev Port Cardiol. 2010; 29(6):1021-36. Velásquez C. Manejo odontológico integral en centro quirúrgico de un paciente con Sindrome de Marfan. Odontol Pediatr (Lima). 2015;14(1):80-5. Tsang AK, Taverne A, Holcombe T. Marfan syndrome: a review of the literature and case report. Spec Care Dentist. 2013;33(5):248-54. Bilodeau JE. Retreatment of a patient with Marfan syndrome and severe root resorption. Am J Orthod Dentofacial Orthop. 2010;137(1):123-34. Baraldi CEE, Paris MF, Robinson WM. A síndrome de Marfan e seus aspectos odontológicos: relato de caso e revisão da literatura. Rev Fac Odontol Porto Alegre. 2008;49(3):36-9. Sinha A, Kaur S, Raheel SA, Kaur K, Alshehri M, Kujan O. Oral manifestations of a rare variant of Marfan syndrome. Clin Case Rep. 2017;5(9):1429-34. Anuthama K, Prasad H, Ramani P, Premkumar P, Natesan A, Sherlin HJ. Genetic alterations in syndromes with oral manifestations. Dent Res J (Isfahan). 2013;10(6):713-22. Jain E, Pandrey RK. Marfan Syndrome. BMJ Case Rep. 2013;25(16):16-22. Staufenbiel I, Hauschild C, Kahl-Nieke B, Vahle-Hinz E, von Kodolitsch Y, Berner M, et al. Periodontal Conditions in patients with Marfan Syndrome: a multienter case conrol study. BMC Oral Health. 2013;13:59. Mallineni SK, Jayaraman J, Yiu CK, King NM. Concomitant occurrence of hypohyperdontia in a patient with Marfan syndrome: a review of the literature and report of a case. J Investig Clin Dent. 2012;3(4):253-57. Gott VL. Antoine Marfan and his syndrome: one hundred years later. Md Med J. 1998;47(5):247-52. Alves IC, Navarro F. Exercício fisico e sindrome de Marfan. Rev Bras Prescrição e Fisiologia do Exercício. 2008;2(8):149-57. Sivasankari T, Mathew P, Austin RD, Devi S. Marfan Syndrome. J Pharm Bioallied Sci. 2017;9(1):73-7. Sabbatini IF. Avaliação dos components anatômicos do sistema estomatognático de crianças com bruxismo, por meio de imagens obtidas por tomografia computadorizada cone beam [dissertação de Mestrado]. Ribeirão Preto: Universidade do Estado de São Paulo; 2012. Cistulli PA, Richards GN, Palmisano RG, Unger G, Berthon-Jones M, Sullivan CE. Influence of maxillary constriction on nasal resistance and sleep apnea severity in patients with Marfan's syndrome. Chest. 1996;110(5):1184-8.

APA, Harvard, Vancouver, ISO, and other styles

35

Афолабі Олусегун Еммануель. "A Developmental Perspective to Attention-Deficit Hyperactivity Disorder (ADHD) in Children." East European Journal of Psycholinguistics 3, no. 1 (August 12, 2016): 8–22. http://dx.doi.org/10.29038/eejpl.2016.3.1.olu.

Full text

Abstract:

The debate about diagnoses and treatment of attention deficit hyperactive disorder (ADHD) in children continue to range on between the developmental and biological perspectives. While there is increasing evidence that support the biological susceptibility of the disorder, a number of researches also emphasized the significant effect of environment on the syndrome. This study used developmental perspectives to evaluate and bring together various bio-psychosocial factors that impact on children diagnosed with ADHD. The study explored and integrated the existing and advancing study on ADHD to a more refined pattern that embraced developmental perspectives. The study also discussed how the linkage in childhood ADHD fits within the developmental psychopathology perspective. The study revealed that ADHD as a developmental disorder is influenced by prenatal, biological and psychosocial environmental risk factors, and suggested that better understanding of genomic susceptibilities, family environment and parental characteristics would transform the pathway for development of ADHD in children. References American Psychiatric Association.(2000). Diagnostic and StatisticalManual of MentalDisorders. 4th ed. Washington, DC: American Psychiatric Association. American Psychiatric Association.(2013). Diagnostic and StatisticalManual of MentalDisorders.5th ed. Washington, DC: American Psychiatric Association. Arnsten, A.F, (2007). Catecholamine and second messenger influenceson prefrontalcortical networks of “representational knowledge”:a rational bridge between genetics andthe symptoms of mental illness. Cerebral Cortex, 17, i6–i15. Arnsten, A.F, & Pliszka, S.R. (2011). Catecholamine influences on prefrontalcorticalfunction: relevance to treatment of attentiondeficit/hyperactivity disorder and relateddisorders. Pharmacology, Biochemistry and Behavior, 99, 211–216. Atladóttir H.O, Parner E.T, & Schendel D. (2007). Variation in incidence ofneurodevelopmental disorders with season of birth. Epidemiology, 18, 240–245. Barkley, R. A. (2006). Attention deficit/hyperactivity disorder: A handbook for diagnosisand treatment (3rd ed.). New York: Guilford Baumeister A.A, Hawkins M.F (2001). Incoherence of neuroimaging studies of attentiondeficit/ hyperactivity disorder. Clinical Neuropharmacology, 24, 2–10. Berger I. (2011). Diagnosis of attention deficit hyperactivity disorder: much ado aboutsomething. Israeli Medical Association Journal, 13, 571–574. Berger, A., Posner, M. I. (2000). Pathologies of brain attentionalnetworks. Neuroscienceand Biobehavioral Reviews, 24, 3–5. Biederman J, Faraone S.V, Keenan K, Knee D, &Tsuang M.T (1990): Familygenetic andpsychosocial risk factors in DSM-III attention deficit disorder. Journal of AmericanAcademy of Child and Adolescent Psychiatry, 29, 526 –533. Biederman J, Faraone SV, Keenan K, Tsuang MT (1991b): Evidence of familialassociationbetween attention deficit disorder and major affective disorders. Archives of GeneralPsychiatry, 48, 633–642. Biederman, J, Faraone, S.V, Keenan K, Benjamin, J, Krifcher, B. &Moore C. et al (1992).Further evidence for family-genetic risk factors in attention deficit hyperactivity disorder.Patterns of comorbidity in probands and relativesin psychiatrically and pediatricallyreferred samples. Archives of General Psychiatry, 49, 728 –738. Biederman, J., Milberger, S., Faraone, S. V., Kiely, K., Guite, J.,Mick, E., Ablon, S., Warburton, R., & Reed, E. (1995). Family environment risk factors for attention deficithyperactivity disorder: A test of Rutter’s indicators of adversity. Archives of GeneralPsychiatry, 52, 464–470. Biederman, J., Faraone, S.V., Mick, E., Spencer,T.,Wilens,T., Kiely,K., Guite, J., Ablon, J.S., Reed, E., & Warburton, R. (1995). High risk for attention deficit hyperactivity disorderamong children of parents with childhood onset of the disorder: A pilot study. Journal ofAmerican Psychiatry, 152, 431–435. Biederman J, Faraone S.V, Monuteaux M, Spencer T, Wilens T, Bober M, et al (2004).Gender effects of attention deficit hyperactivity disorder inadults, revisited. BiologicalPsychiatry, 55, 692–700. Brookes, K.,Mill, J.,&Guindalini,C., et al (2006). Acommon haplotype of the dopaminetransporter geneassociated with attention-deficit/hyperactivity disorderand interactingwithmaternal use of alcohol duringpregnancy. Archives of General Psychiatry, 63, 74–81. Brophy, K., Hawi, Z., Kirley, A., Fitzgerald, M., & Gill, M. (2002). Synaptosomalassociated protein 25 (SNAP-25) and attention deficit hyperactivity disorder (ADHD):Evidence of linkage and association in the Irish population. Molecular Psychiatry, 7 , 913–917 Campbell, S. B. (2000). Attention-Deficit/Hyperactivity Disorder: A developmental view.In: Handbook of Developmental Psychopathology. (pp. 383–401). A. J. Sameroff, M.Lewis, & S. Miller (Eds.). New York: Kluwer Academic/Plenum. Carlson, E. A., Jacobvitz, D., & Sroufe, L. A. (1995). A developmental investigation ofinattentiveness and hyperactivity. Child Development, 66, 37–54. Childress, A.C, Berry, S.A (2012). Pharmacotherapy of attention-deficit hyperactivitydisorder in adolescents. Drugs, 72, 309–325. Cortese, S (2012). The neurobiology and genetics of attention-deficit/hyperactivitydisorder (ADHD): what every clinician shouldknow. European Journal of PaediatricNeurology, 16, 422–433. Dopheide, J.A (2005). ASHP therapeutic position statement on theappropriate use ofmedications in the treatment of attention deficit/hyperactivity disorder in paediatricpatients. American Journal of Health System Pharmacy, 62, 1502– 1509. Coghill, D., Nigg, J., Rothenberger, A., Sonuga-Barke, E., & Tannock, R. (2005). Withercausal models in the neuroscience of ADHD? Developmental Science, 8, 105–114. Cummings, E. M., Davies, P., & Campbell, S. B. (2000). Developmental Psychopathologyand Family Process: Research, Theory, and Clinical Implications. New York: Guilford. Faraone, S. V., Perlis, R. H., Doyle, A. E., Smoller, J. W., Goralnick, J. J., Holmgren, M.A., et al. (2005). Molecular genetics of attention-defi cit/hyperactivity disorder. BiologicalPsychiatry, 57 , 1313–1323. Faraone, S, Biederman, J, Krifcher Lehman, B, Keenan, K, Norman, D, Seidman, L. et al.(1993). Evidence for the independent familial transmission of attentiondeficit hyperactivitydisorder and learning disabilities: Results froma family genetic study. American Journalof Psychiatry, 150, 891– 895. Faraone, S. V, Tsuang, M. T. (1995). Methods in psychiatric genetics. In: Textbook inPsychiatric Epidemiology, Tohen, M, Tsuang, M., Zahner, G. (Eds). (pp. 81–134). NewYork: John Wiley& Sons. Faraone, S. V. & Biederman, J. (1998). Neurobiology of attentiondeficit hyperactivitydisorder. Biological Psychiatry, 44, 951–958. Faraone S.V, Biederman J, &MonuteauxM.C. (2001a). Attention deficit hyperactivitydisorder with bipolar disorder in girls: Further evidence for a familial subtype? Journal ofAffect Disorders, 64, 19 –26. Haraone S.V, Doyle A.E (2001): The nature and heritability of attentiondeficit/hyperactivity disorder. Child and Adolescent Psychiatric Clinics of North America,10, 299 –316, viii–ix. Faraone, S.V., & Biederman, J. (2000). Nature, nuture, and attentiondeficit hyperactivitydisorder. Developmental Review, 20, 568–581. Faraone S.V, Perlis R.H, Doyle A.E, Smoller J.W, Goralnick J, &Holmgren M.A, et al.(2005). Molecular genetics of attention deficit hyperactivity disorder. BiologicalPsychiatry, 57, 1313–1323. Gray, J. A., Feldon, J., Rawlins, J. N. P., Hemsley, D. R., & Smith, A. D. (1991) Theneuropsychology of schizophrenia. Behavioral and Brain Sciences, 14, 1–84. Gray, J. A. (1982). The neumpsychology of anxiety. New York: Oxford University Press. Halperin, J. M., & Healey, D. M. (2011). The infl uences of environmental enrichment,cognitive enhancement,and physical exercise on brain development: Can we alter thedevelopmental trajectory of ADHD? Neuroscience and Biobehavioral Reviews, 35 , 621–634. Hauschild K.M, Mouridsen S.E, & Nielsen S. (2005). Season of birth inDanish childrenwith language disorder born in the 1958–1976 period. Neuropsychobiology; 51, 93–99. Hudziak J.J, Rudiger L.P, Neale M.C, Heath A.C, & Todd R.D (2000). A twin study ofinattentive,aggressive, and anxious/depressed behaviors. Journal of the American Academyof Child and Adolescent Psychiatry, 39, 469 –476. Kahn, R. S., Khoury, J. & Nichols,W.C., et al (2003). Role of dopamine transportergenotype and maternal prenatal smoking in childhood hyperactive-impulsive,inattentive,and oppositional behaviors. Journal of Pediatrics, 143, 104–110. Kesner R.P, & Churchwell J.C (2011). An analysis of rat prefrontal cortexin mediatingexecutive function. Neurobiology of Learning and Memory, 96, 417–431. Kuntsi, J.,& Stevenson, J. (2000). Hyperactivity in children:Afocuson genetic research andpsychological theories. Clinical Child and Family Psychology Review, 3, 1–24. Langley, K., Rice, F., & van den Bree, M. B., et al (2005). Maternal smoking duringpregnancy as an environmental risk factor for attention deficit hyperactivity disorderbehaviour. A Review. Minerva Pediatrica, 57, 359–371. Manshadi M, Lippmann S, O’Daniel R, & Blackman A (1983): Alcohol abuse andattention deficit disorder. Journal of Clinical Psychiatry, 44, 379 –380 Martin N, Scourfield J, McGuffin P (2002).Observer effects and heritability ofchildhoodattention-deficit hyperactivity disorder symptoms. British Journal of Psychiatry, 80, 260 –265. Neale, B. M., Medland, S. E., Ripke, S., Asherson, P., Franke, B., Lesch, K. P., et al.(2010). Meta-analysis of genome-wide association studies of attention-defi cit/hyperactivity disorder. Journal of the American Academy of Child and AdolescentPsychiatry, 49 , 884–897. Nigg J, Nikolas M, & Burt S. A(2010). Measured gene-by-environment interaction inrelation to attention-deficit/hyperactivity disorder. Journal of the American Academy ofChild and Adolescent Psychiatry, 49, 863–73. Oades, R. D., Lasky-Su, J., Christiansen, H., Faraone, S.V., Sonuga-Barke, E. J., Banaschewski, T., et al. (2008). The influence of serotonin- and other genes onimpulsivebehavioral aggression and cognitive impulsivity in children with attentiondeficit/hyperactivity. A Developmental Perspective on ADHD disorder (ADHD): Findingsfrom a family-based association test (FBAT) analysis. Behavioral and Brain Functions, 4,4–48. Pastor P. N & Reuben C.A. (2008). Diagnosed attention deficit hyperactivity disorder andlearning disability: United States, 2004–2006. Vital Health Statistics, 10, 1–14. Quay, H. C. (1988a). Attention deficit disorder and the behavioral inhibitionsystem: Therelvance of the neuropsychological theory of Jeffrey A. Gray. In: Attention deficitdisorder: Criteria, cognition, intervention (pp. 117–126). L. M. Bloomingdale & J.Sergeant (Eds.). NewYork: Pergamon. Quay, H. C. (1988b). The behavioral reward and inhibition systems inchildhood behaviordisorder. In: Attentiondeficit disorder W; New research in treatment, psychopharnmcology,and attention (pp. 176–186). L. M. Bloomingdale (Ed.). NA: Pergamon. Quay, H. C. (1996, January). Gray'sbehavioral inhibition in ADHD:An update. Paperpresented at the annual meeting of the InternationalSociety for Research in Child andAdolescent Psychopathology, Los Angeles, CA. Rader, R, McCauley L,& Callen, E.C. (2009). Current strategies in thediagnosis andtreatment of childhood attention-deficit/hyperactivity disorder. American FamilyPhysician, 79, 657–665. Robbins, T. W. (2003). Dopamine and cognition. Currpin Neurol,16, (2), S1–S2. Rutter, M, Cox, A, Tupling, C, Berger, M, &Yule, W. (1975). Attainment and adjustmentin two geographical areas. 1—The prevalence of psychiatric disorders. British Journal ofPsychiatry, 126, 493–509. Rutter, M., &Sroufe, L. A. (2000). Developmental psychopathology: Concepts andchallenges. Development and Psychopathology, 12, 265–296. Sergeant, J. (2000). The cognitive-energetic model: An empiricalapproach to attentiondeficit hyperactivity disorder. Neuroscienceand Biobehavioral Reviews, 24, 7–12. Sherman D, McGue M, &Iacono W (1997). Twin concordance for attention deficithyperactivity disorder: A comparison of teachers’ and mothers’reports. American Journalof Psychiatry, 154, 532–535. Sonuga-Barke, E. J., Auerbach, J., Campbell, S. B., Daley, D., & Thompson, M. (2005).Preschool varieties of hyperactive and dysregulated behaviour: Multiple pathways betweenrisk and disorder. Developmental Science, 8 , 141–150. Sonuga-Barke, E. J., Bitsakou, P., & Thompson, M. (2010). Beyond the dual pathwaymodel: Evidence for the dissociation of timing, inhibitory, and delayrelated impairments inattention-defi cit/hyperactivity disorder. Journal of the American Academy of Child andAdolescent Psychiatry, 49 , 345–355. Sonuga-Barke, E. J., & Halperin, J. (2010). Developmental phenotypes and causalpathways in attention deficit/hyperactivity disorder: Potential targets for earlyintervention? Journal of Child Psychology and Psychiatry, 51, 368–398. Sprich-Buckminster S, Biederman J, Milberger S, Faraone S, &Krifcher LehmanB (1993):Are perinatal complications relevant to the manifestation ofADD? Issues of comorbidityand familiality. Journal of American Academy of Child and Adolescent Psychiatry,32,1032–1037 Swanson, J. M., Sunohara, G. A., Kennedy, J. L., Regino,R., Fineberg, E.,Wigal, T.,Lerner, M.,Williams, L., LaHoste,G. J.,&Wigal, S. (1998). Association of the dopaminereceptorD4 (DRD4) gene with a refined phenotype of attention deficithyperactivitydisorder (ADHD): A family–based approach.Molecular Psychiatry, 3, 38–41. Taylor, E. (1999). Developmental neuropsychopathology of attentiondeficit and impulsiveness. Development and Psychopathology, 11, 607–628. Thapar, A.,O’Donovan,M., &Owen,M. J. (2005b). The genetics of attention deficithyperactivity disorder. Human Molecular Genetics, 14, 275–282. Thapar, A., Langley, K.,O’Donovan,M. (2006). Refining the attention deficithyperactivity disorderphenotype formolecular genetic studies. Molecular Psychiatry, 11,714–720. Thapar A, Langley K, &Asherson P, (2007). Gene–environment interplay in attentiondeficit hyperactivity disorder and the importance of a developmental perspective. BritishJournal of Psychiatry 190, 1–3. Tochigi M, Okazaki Y, & Kato N, (2004). What causes seasonality of birth inschizophrenia? Neuroscience Res, 48, 1–11 Trent S & Davies W. (2012). The influence of sex-linked genetic mechanisms on attentionand impulsivity. Biological Psychology, 89, 1–13. United States, 2003 and 2007 (2010). Increasing prevalence of parent-reported attentiondeficit/hyperactivity disorder among children, MMWR Morb Mortal Wekly Rep, 59, 1439–43. Yehuda, R. (2000). Biology of posttraumatic stress disorder. Journal of ClinicalPsychiatry, 61, 14–21. Zimmer, L (2009). Positron emission tomography neuroimagingfor a better understandingof the biology of ADHD. Neuropharmacology, 57, 601–607.

APA, Harvard, Vancouver, ISO, and other styles

36

Hara, H., M. Tagiri, M. Hirabayashi, and S. Hochi. "60 EFFECT OF CAKE COLLAPSE ON THE INTEGRITY OF FREEZE-DRIED BULL SPERMATOZOA." Reproduction, Fertility and Development 26, no. 1 (2014): 144. http://dx.doi.org/10.1071/rdv26n1ab60.

Full text

Abstract:

During freezing, a solution changes into an amorphous phase at the glass transition temperature of the maximally freeze-concentrated phase (T′g). The solution exhibits a cake-like porous structure under the optimal freeze-drying process. However, if the product temperature is higher than theT′g during the drying phase, the glassy material will undergo viscous flow, resulting in loss of the porous structure. This is defined as the collapse phenomenon and may be related to instability of the freeze-dried products. The purpose of the present study was to investigate the effect of cake collapse on freeze-dried bull spermatozoa. One-way ANOVA was used for comparison of T′g, DNA damage, and blastocyst yield. When the ANOVA was significant, differences among means were analysed by a Tukey test. In Experiment 1, factors affecting the T′g were investigated. Using differential scanning calorimetry, theT′g of an EGTA buffer (10 mM TRIS-HCl, 50 mM EGTA, and 50 mM NaCl, pH8.0) that has been conventionally used for sperm freeze-drying was determined to be –45.0°C. Modification of the EGTA buffer composition by complete removal of NaCl and addition of 0.5 M trehalose (referred to hereafter as mEGTA buffer) resulted in an increase in theT′g up to –27.7°C. The T′g of the mEGTA buffer cooled by direct immersing into liquid nitrogen (–29.4°C) was slightly lower (P < 0.05) than that cooled slowly at 20 and 1°C min–1 (–27.6 and –27.2°C, respectively). In Experiment 2, the integrity of freeze-dried and rehydrated bull spermatozoa was investigated. Spermatozoa from a Japanese Black bull were suspended into mEGTA buffer (3 × 107 cells mL–1), cooled at 20°C min–1, and then processed for drying for 6 h at 0, –15, and –30°C (ALPHA2-4; Martin Christ Gefriertrocknungsanlagen GmbH, Osterode am Harz, Germany). Cakes were collapsed when the sperm suspension was dehydrated either at 0 or –15°C. In vitro-matured bovine oocytes were injected with rehydrated sperm, chemically activated (5 μM ionomycin, 7% ethanol, and 2 mM 6-DMAP), and then cultured for 8 days. Blastocyst yields after injection of sperm dried at 0 and –15°C, calculated from cleaved oocytes, were significantly lower than that of sperm dried at –30°C (0.7–3.7% v. 14.2%; P < 0.05). The level of DNA damage, assessed by the alkaline comet assay, was not different between the sperm populations dried at 0 and –30°C. Transmission electron microscopic observation revealed that the sperm membrane dried at 0°C was more damaged compared with that dried at –30°C (P < 0.05; chi-squared test with Bonferroni correction). In conclusion, incidence of collapse in freeze-dried cake may be a detrimental factor for maintenance of sperm integrity after freeze-drying, and can be inhibited by controlling the T′g of the buffer and drying phase temperature. H. Hara is Research Fellow of the Japan Society for the Promotion of Science (JSPS). This work was supported by a grant-in-aid for basic research from JSPS (no. 24580407) to S. Hochi.

APA, Harvard, Vancouver, ISO, and other styles

37

Sooväli, P., M. Tikhonova, and P. Matušinsky. "First Report of Ramularia Leaf Spot Caused by Ramularia collo-cygni on Leaves and Seeds of Barley in Estonia." Plant Disease 98, no. 7 (July 2014): 997. http://dx.doi.org/10.1094/pdis-10-13-1035-pdn.

Full text

Abstract:

Ramularia leaf spot (RLS) is a disease of barley (Hordeum vulgare) caused by the fungus Ramularia collo-cygni Sutton & Waller (Rcc). Rcc causes necrotic lesions, premature senescence of leaves, and yield reduction. Under Estonian conditions, there are usually no leaf spots on the upper leaves of barley prior to flowering. In 2009, 2010, and 2012, symptoms similar to those of RLS were observed on leaves of spring and winter barley in several Estonian agricultural regions. Approximately 30% of the plants in affected fields were symptomatic. Symptoms were not observed in 2011, which was a dry and hot year. Initial symptoms were small brown spots, beginning on the upper leaves (flag leaf, F-1 leaf) at the flowering growth stage (4). Later, the spots spread to the sheaths, stems, and awns and became necrotic. The lateral margins of the spots were delimited by the leaf veins and spots are surrounded by a chlorotic halo. During summer 2012, two samples of 15 F-1 leaves were collected from spring barley cv. Maali and line SJ111609 from the Estonian Crop Research Institute in eastern Estonia in late July at growth stage 71 (4). In addition, six grain samples, containing 200 seeds each of the cv. Maali, were collected from different agricultural regions in Estonia, along with one grain sample of SJ111609 from Jõgeva. All samples were collected from untreated plots and leaves were observed under a dissecting microscope, revealing white clusters of conidiophores in rows on the undersides of the leaves. Conidia and conidiophores were scraped aseptically from the leaf surface using a sterile needle under a dissecting microscope and transferred to potato dextrose agar (PDA) containing ampicillin sodium salt (50 mg l−1). Plates were incubated at 18°C in the dark for 20 days until fungal mycelia were produced. The fungus was initially identified as Rcc on the basis of morphological characteristics (3). Colorless, 0- to 3-septate conidiophores were 15 to 17 × 2 to 5 μm, with a strongly curved end. Conidia were 7 to 11 × 3 to 6 μm, solitary, subglobose, single-celled, and of a darkish color. To confirm the presence of Rcc, DNA was extracted from the original barley leaf material, milled seeds, and positive control mycelia of Rcc grown on PDA using DNeasy Plant Mini Kit (Qiagen Gmbh, D-40724 Hilden, Germany) following manufacturer's guides. Rcc specific primers RC3 and RC5 (1) were used. A positive control consisting of 1 ng of purified Rcc DNA was included in the PCR. Standard PCR was conducted in a SEE AMP Seegene cycler. PCR were carried out in 20 μl volumes, containing 2 μl of DNA, 10 μl PCR mix, 0.4 μl each of forward and reverse Rcc primers, and 7.2 μl H2O. Qualitative detection analyzed by standard PCR with primers RC3 and RC5 revealed the presence of Rcc in symptomatic leaves and seeds. To complete Koch's postulates, a pathogenicity test was performed. Twenty-five barley seedlings were grown under controlled conditions (15°C/48 h dark, 16 h light/8 h dark, 70% RH) and spray-inoculated with a suspension of Rcc mycelium fragments as described by Macepeace et al. (2). The pathogen was re-isolated from leaves with necrotic lesions similar to those observed in the field, thus fulfilling Koch's postulates. To our knowledge, this is the first confirmed report of Ramularia leaf spot caused by Ramularia collo-cygni on barley in Estonia. References: (1) P. Frei et al. J. Phytopathol. 155:281, 2007. (2) J. C. Makepeace et al. Plant Pathol. 57:991, 2008. (3) B. C. Sutton and J. M. Waller. Trans. Brit. Mycol. Soc. 90:55, 1988. (4) J. C. Zadoks et al. Weed Res. 14:415, 1974.

APA, Harvard, Vancouver, ISO, and other styles

38

Sodini, Jean-Pierre. "Travaux récents sur des bâtiments byzantins et géorgiens à l'Ouest d'Antioche - Wachtang Djobadze , ARCHEOLOGICAL INVESTIGATIONS IN THE REGION WEST OF ANTIOCH ON-THE-ORONTES, with contributions by M. Hendy , N. Lowick , C. Mango , D. M. Metcalf and H. Seyrig (+), (Forschungen zur Kunstgeschichte und christlichen Archäologie, Bd 13, Franz Steiner Verlag Wiesbaden GmbH, Stuttgart 1986). Pages 225, planches 100, plans 10. Leinen mit Schutzumschlag DM 168,- ISBN 3-515-04081-1." Journal of Roman Archaeology 1 (1988): 229–34. http://dx.doi.org/10.1017/s1047759400010278.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

Wu, C. Y., P. S. Chu, and H. Y. Yang. "AB1010 CLINICAL SPECTRUM AND IMMUNE ANALYSIS OF PATIENTS WITH CRYOPYRIN-ASSOCIATED AUTOINFLAMMATORY SYNDROME IN TAIWAN." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 1798.1–1798. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5072.

Full text

Abstract:

Background:Cryopyrin-associated periodic syndromes (CAPS) are emerging autoinflammatory diseases with available treatment. No reports have yet been reported from Taiwan.Objectives:We reviewed cases suspected with CAPS to identify its existence in Taiwan.Methods:Genomic DNA from one hundred and ten cases with symptom signs suggestive of CAPS(1) between 2016-2019 were sent for NLRP3 gene analysis. Clinical presentations, laboratory data, treatment regimens, as well as inflammasome activities were analyzed among those treated in a tertiary medical center in northern Taiwan.Results:Among the 110 cases sequenced, 16 of them were found to carry missense mutations within the NLRP3 gene. Fourteen cases harbored known pathogenic genetic variants (c.1316C>T; c.1574A>T; and c.907G>C) and two carried novel NLRP3 missense mutations (c.210G>A, c.1371G>T)(2) with unknown pathophysiological roles. Through chart review, chronic urticarial, systemic juvenile idiopathic arthritis, Behcet’s disease and refractory Kawasaki disease were most likely diagnosed before genetic analysis were arranged. As compared to chronic infantile neurological, cutaneous and articular syndrome (CINCA) and Muckle-Wells syndrome (MWS), familial cold autoinflammatory syndrome (FCAS) was the most frequently observed clinical presentation. Plasma serumamyloidA (SAA) and IL-1b were both significantly elevated among the cases diagnosed with CAPS as compared to the controls (p<0.05). IL-18, on the other hand, showed no significant differences between the groups. While the presence of LPS without ATP significantly increased the level of IL-1b in the PBMC stimulation test, IL-18 were significantly elevated in the confirmed CAPS with or without ATP upon LPS stimulation (all p<0.05). Caspase 1 activity were also tested positive among the cases with CAPS. Furthermore, we compared the immune profiles between those CAPS cases harboring pathogenic mutations with the 2 harboring unreported NLRP3 missense mutations and discovered that the PBMC stimulation test in cases with c.210G>A and c.1371G>T mutation did not differ from the healthy controls.Conclusion:The number of NLRP3 gene alterations among patients suspected with CAPS in Taiwan is not low. In order to identify potential patients for proper medical intervention in the future, physician awareness, genetic testing as well as functional analysis are important.References:[1]Kuemmerle-Deschner JB, Ozen S, Tyrrell PN, Kone-Paut I, Goldbach-Mansky R, Lachmann H, et al. Diagnostic criteria for cryopyrin-associated periodic syndrome (CAPS). Ann Rheum Dis. 2017;76(6):942-7.[2]Van Gijn ME, Ceccherini I, Shinar Y, Carbo EC, Slofstra M, Arostegui JI, et al. New workflow for classification of genetic variants’ pathogenicity applied to hereditary recurrent fevers by the International Study Group for Systemic Autoinflammatory Diseases (INSAID). J Med Genet. 2018;55(8):530-7Disclosure of Interests:Chao-Yi Wu Speakers bureau: Abbvie, Boehringer Ingelheim International GmbH, Nestle, Pi-Shuang Chu: None declared, Huang-Yu Yang: None declared

APA, Harvard, Vancouver, ISO, and other styles

40

Knight, John. "Antidepressants, Antipsychotics, Anxiolytics, from Chemistry and Pharmacology to Clinical Application , Volumes 1 and 2. Edited by H. Buschmann, J. L. Díaz, J. Holenz, A. Párraga, A. Torrens, J. M. Vela. Wiley-VCH Verlag, GmbH and Co. KGaA: Weinheim. 2007. Vol. 1, 616 pp; Vol. 2, 580 pp plus indices, 1260 pp total. Hardcover £215.00/301.00. 978-527-31058-6." Organic Process Research & Development 12, no. 4 (July 2008): 787. http://dx.doi.org/10.1021/op8000965.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Dalmann, A., S. Murthy, M. Wannick, G. Eleftheriadis, A. Müller, D. Zillikens, H. Busch, C. Sadik, and G. Riemekasten. "AB0166 IMMUNOGLOBULIN G DERIVED FROM PATIENTS WITH SYSTEMIC SCLEROSIS IMPRINTS A PRO-INFLAMMATORY AND PRO-FIBROTIC PHENOTYPE IN MONOCYTE-LIKE THP-1 CELLS." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 1383.2–1383. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5218.

Full text

Abstract:

Background:Regulatory IgG autoantibodies directed against diverse G protein-coupled receptors (GPCR),i.e.antibodies with agonistic or antagonistic activity are abundant in human serum. The serum titers of autoantibodies targeting angiotensin II receptor 1 (AT1) and endothelin receptor A (ETA) are specifically altered in autoimmune diseases such as systemic sclerosis (SSc). Disease-promoting mechanisms regulated by anti-AT1and anti-ETAIgG are still elusive, but induction of pro-inflammatory and pro-fibrotic chemokines (CXCL8, CCL18) has been suggested to be one of them.Objectives:To determine the cytokine and phospho-kinase profiles induced in monocyte-like cells by IgG derived from SSc patients (SSc-IgG) enriched with anti-AT1and anti-ETAantibodies in comparison to IgG derived from healthy donors (IgG-HD).Methods:A monocyte-like cell line (THP-1) was culturedin vitroand stimulated with IgG (1 mg/ml) derived from SSc patients or HD in the presence of various inhibitors/blockers for 24h. Then, supernatants were analyzed by a human cytokine/chemokine array. Data were analyzed using bio-mathematical tools such as generalized t-test including the robust regression method from R/Bioconductor package LIMMA. In addition, THP-1 cells were culturedin vitroand stimulated with IgG (1 mg/ml) derived from SSc patients or HD for up to 30 minutes. Thereafter, cell lysates were assayed for the kinome employing a human phospho-kinase array. To validate potential effects of transcription factor inhibition, release of CXCL8 and CCL18 into the supernatant was measured by Elisa.Results:In general, SSc-IgG induced the release of most cytokines by THP-1 cells more pronouncedly than HD-IgG. The bio-mathematical analysis suggested that stimuli, responsible for the shift of the THP-1 cell cytokine profile, are more abundant in SSc-IgG than in HD-IgG. Based upon these findings a gene set enrichment analysis for transcription factors yielded the transcription factors NF-κB, AP-1, and PRDM1 (Blimp-1) as putative major regulatory hubs for the response of THP-1 cells to SSc-IgG. Further, SSc-IgG altered the phosphorylation status of several proteins, indicative of an involvement of MAPK and/or JAK/STAT pathways. Interestingly, a role for AP-1 was also proposed by the inhibition of CXCL8 and CCL18 release following pretreatment of THP-1 cells with an AP-1 blocker.Conclusion:Herein, we demonstrate that IgG of SSc patients, enriched with anti-AT1and anti-ETAautoantibodies drives THP-1 cells towards a general pro-inflammatory and pro-fibrotic phenotype, which is reflected by broad changes in the secretome and kinome of these cells. Furthermore, our results highlight AP-1 as critical regulator of gene transcription of CXCL8 and CCL18 in a monocyte-like cell line.References:[1]Cabral-Marques O, Marques A, Giil LM, De Vito R, Rademacher J, Günther J, Lange T, Humrich JY, Klapa S, Schinke S, et al. GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis.Nat Commun(2018)9:5224. doi:10.1038/s41467-018-07598-9[2]Günther J, Kill A, Becker MO, Heidecke H, Rademacher J, Siegert E, Radi M, Burmester G-R, Dragun D, Riemekasten G. Angiotensin receptor type 1 and endothelin receptor type A on immune cells mediate migration and the expression of IL-8 and CCL18 when stimulated by autoantibodies from systemic sclerosis patients.Arthritis Res Ther(2014)16:R65. doi:10.1186/ar4503Disclosure of Interests:Anja Dalmann: None declared, Sripriya Murthy: None declared, Melanie Wannick: None declared, Georgios Eleftheriadis: None declared, Antje Müller: None declared, Detlef Zillikens: None declared, Hauke Busch: None declared, Christian Sadik: None declared, Gabriela Riemekasten Consultant of: Cell Trend GmbH, Janssen, Actelion, Boehringer Ingelheim, Speakers bureau: Actelion, Novartis, Janssen, Roche, GlaxoSmithKline, Boehringer Ingelheim, Pfizer

APA, Harvard, Vancouver, ISO, and other styles

42

Drewes, G. W. J., Taufik Abdullah, Th End, T. Valentino Sitoy, R. Hagesteijn, David G. Marr, R. Hagesteijn, et al. "Book Reviews." Bijdragen tot de taal-, land- en volkenkunde / Journal of the Humanities and Social Sciences of Southeast Asia 143, no. 4 (1987): 555–613. http://dx.doi.org/10.1163/22134379-90003324.

Full text

Abstract:

- G.W.J. Drewes, Taufik Abdullah, Islam and society in Southeast Asia, Institute of Southeast Asian studies, Singapore, 1986, XII and 348 pp., Sharon Siddique (eds.) - Th. van den End, T.Valentino Sitoy, A history of Christianity in the Philippines. The initial encounter , Vol. I, Quezon City (Philippines): New day publishers, 1985. - R. Hagesteijn, David G. Marr, Southeast Asia in the 9th to 14th centuries, Singapore: Institute of Southeast Asian studies and the research school of Pacific studies of the Australian National University, 1986, 416 pp., A.C. Milner (eds.) - R. Hagesteijn, Constance M. Wilson, The Burma-Thai frontier over sixteen decades - Three descriptive documents, Ohio University monographs in international studies, Southeast Asia series No. 70, 1985,120 pp., Lucien M. Hanks (eds.) - Barbara Harrisson, John S. Guy, Oriental trade ceramics in South-east Asia, ninth to sixteenth century, Oxford University Press, Singapore, 1986. [Revised, updated version of an exhibition catalogue issued in Australia in 1980, in the enlarged format of the Oxford in Asia studies of ceramic series.] 161 pp. with figs. and maps, 197 catalogue ills., numerous thereof in colour, extensive bibliography, chronol. tables, glossary, index. - V.J.H. Houben, G.D. Larson, Prelude to revolution. Palaces and politics in Surakarta, 1912-1942. VKI 124, Dordrecht/Providence: Foris publications 1987. - Marijke J. Klokke, Stephanie Morgan, Aesthetic tradition and cultural transition in Java and Bali. University of Wisconsin, Center for Southeast Asian studies, Monograph 2, 1984., Laurie Jo Sears (eds.) - Liaw Yock Fang, Mohamad Jajuli, The undang-undang; A mid-eighteenth century law text, Center for South-East Asian studies, University of Kent at Canterbury, Occasional paper No. 6, 1986, VIII + 104 + 16 pp. - S.D.G. de Lima, A.B. Adam, The vernacular press and the emergence of modern Indonesian consciousness (1855-1913), unpublished Ph. D. thesis, School of Oriental and African studies, University of London, 1984, 366 pp. - J. Thomas Lindblad, K.M. Robinson, Stepchildren of progress; The political economy of development in an Indonesian mining town, Albany: State University of New York Press, 1986, xv + 315 pp. - Pauline Lunsingh Scheurleer, J.E. van Lohuizen-de Leeuw, Indo-Javanese Metalwork, Linden-Museum, Stuttgart, Staatliches Museum für Völkerkunde, 1984, 218 pp. - H.M.J. Maier, V. Matheson, Perceptions of the Haj; Five Malay texts, Singapore: Institute of Southeast Asian studies (Research notes and discussions paper no. 46), 1984; 63 pp., A.C. Milner (eds.) - Wolfgang Marschall, Sandra A. Niessen, Motifs of life in Toba Batak texts and textiles, Verhandelingen KITLV 110. Dordrecht/Cinnaminson: Foris publications, 1985. VIII + 249 pp., 60 ills. - Peter Meel, Ben Scholtens, Opkomende arbeidersbeweging in Suriname. Doedel, Liesdek, De Sanders, De kom en de werklozenonrust 1931-1933, Nijmegen: Transculturele Uitgeverij Masusa, 1986, 224 pp. - Anke Niehof, Patrick Guinness, Harmony and hierarchy in a Javanese kampung, Asian Studies Association of Australia, Singapore: Oxford University Press, 1986, 191 pp. - C.H.M. Nooy-Palm, Toby Alice Volkman, Feasts of honor; Ritual and change in the Toraja Highlands, Urbana and Chicago: University of Illinois Press, Illinois Studies in Anthropology no. 16, 1985, IX + 217 pp., 2 maps, black and white photographs. - Gert J. Oostindie, Jean Louis Poulalion, Le Surinam; Des origines à l’indépendance. La Chapelle Monligeon, s.n., 1986, 93 pp. - Harry A. Poeze, Bob Hering, The PKI’s aborted revolt: Some selected documents, Townsville: James Cook University of North Queensland. (Occasional Paper 17.) IV + 100 pp. - Harry A. Poeze, Biografisch woordenboek van het socialisme en de arbeidersbeweging in Nederland; Deel I, Amsterdam: Stichting tot Beheer van Materialen op het Gebied van de Sociale Geschiedenis IISG, 1986. XXIV + 184 pp. - S. Pompe, Philipus M. Hadjon, Perlindungan hukum bagi rakyat di Indonesia, Ph.D thesis Airlangga University, Surabaya: Airlangga University Press, 1985, xviii + 308 pp. - J.M.C. Pragt, Volker Moeller, Javanische bronzen, Staatliche Museen Preussischer Kulturbesitz, Museum für Indische Kunst, Berlin, 1985. Bilderheft 51. 62 pp., ill. - J.J. Ras, Friedrich Seltmann, Die Kalang. Eine Volksgruppe auf Java und ihre Stamm-Myth. Ein beitrag zur kulturgeschichte Javas, Stuttgart: Franz Steiner Verlag Wiesbaden GmbH, 1987, 430 pp. - R. Roolvink, Russell Jones, Hikayat Sultan Ibrahim ibn Adham, Berkeley: Center for South and Southeast Asia Studies, University of California, Monograph Series no. 57, 1985. ix, 332 pp. - R. Roolvink, Russell Jones, Hikayat Sultan Ibrahim, Dordrecht/Cinnaminson: Foris, KITLV, Bibliotheca Indonesica vol. 24, 1983. 75 pp. - Wim Rutgers, Harry Theirlynck, Van Maria tot Rosy: Over Antilliaanse literatuur, Antillen Working Papers 11, Caraïbische Afdeling, Koninklijk Instituut voor Taal-, Land- en Volkenkunde, Leiden, 1986, 107 pp. - C. Salmon, John R. Clammer, ‘Studies in Chinese folk religion in Singapore and Malaysia’, Contributions to Southeast Asian Ethnography no. 2, Singapore, August 1983, 178 pp. - C. Salmon, Ingo Wandelt, Wihara Kencana - Zur chinesischen Heilkunde in Jakarta, unter Mitarbeit bei der Feldforschung und Texttranskription von Hwie-Ing Harsono [The Wihara Kencana and Chinese Therapeutics in Jakarta, with the cooperation of Hwie-Ing Harsono for the fieldwork and text transcriptions], Kölner ethopgraphische Studien Bd. 10, Berlin: Dietrich Reimer Verlag, 1985, 155 pp., 1 plate. - Mathieu Schoffeleers, 100 jaar fraters op de Nederlandse Antillen, Zutphen: De Walburg Pers, 1986, 191 pp. - Mathieu Schoffeleers, Jules de Palm, Kinderen van de fraters, Amsterdam: De Bezige Bij, 1986, 199 pp. - Henk Schulte Nordholt, H. von Saher, Emanuel Rodenburg, of wat er op het eiland Bali geschiedde toen de eerste Nederlanders daar in 1597 voet aan wal zetten. De Walburg Pers, Zutphen, 1986, 104 pp., 13 ills. and map. - G.J. Schutte, W.Ph. Coolhaas, Generale missiven van Gouverneurs-Generaal en Raden aan Heren XVII der Verenigde Oostindische Compagnie, VIII: 1725-1729, Rijks Geschiedkundige Publicatiën, Grote Serie 193, ‘s-Gravenhage, 1985, 275 pp. - H. Steinhauer, Jeff Siegel, Language contact in a plantation environment. A sociolinguistic history of Fiji, Cambridge: Cambridge University Press, 1987, xiv + 305 pp. [Studies in the social and cultural foundations of language 5.] - H. Steinhauer, L.E. Visser, Sahu-Indonesian-English Dictionary and Sahu grammar sketch, Verhandelingen van het KITLV 126, Dordrecht: Foris Publications, 1987, xiv + 258 pp., C.L. Voorhoeve (eds.) - Taufik Abdullah, H.A.J. Klooster, Indonesiërs schrijven hun geschiedenis: De ontwikkeling van de Indonesische geschiedbeoefening in theorie en praktijk, 1900-1980, Verhandelingen KITLV 113, Dordrecht/Cinnaminson: Foris Publications, 1985, Bibl., Index, 264 pp. - Maarten van der Wee, Jan Breman, Control of land and labour in colonial Java: A case study of agrarian crisis and reform in the region of Ceribon during the first decades of the 20th century, Verhandelingen of the Royal Institute of Linguistics and Anthropology, Leiden, No. 101, Dordrecht: Foris Publications, 1983. xi + 159 pp.

APA, Harvard, Vancouver, ISO, and other styles

43

Ameri, Hamideh, Marjaneh Ghavamnasiri, and Ehsan Abdoli. "Effects of Load Cycling on the Microleakage of Beveled and Nonbeveled Margins in Class V Resin-Based Composite Restorations." Journal of Contemporary Dental Practice 11, no. 5 (2010): 25–32. http://dx.doi.org/10.5005/jcdp-11-5-25.

Full text

Abstract:

Abstract Aim This study evaluated the influence of mechanical loading and thermocycling on microleakage of class V resin-based composite restorations with and without enamel bevel. Methods and Materials Sixty class V cavity preparations measuring 3.0 mm wide (mesiogingivally) x 2.0 mm high (occluso-gingivally) x 1.5 mm deep with the occlusal margin in enamel and the gingival margin in cementum were prepared on the buccal surfaces of human premolars using a #12 diamond round bur (Drendel & Zweiling Diamant GmbH, Lemgo, Germany) in a high-speed, water-cooled handpiece. The specimens were then divided into two groups of 30 specimens each, based on the type of enamel cavosurface margin configuration as beveled or nonbeveled (butt joint). After restoring the preparations with a flowable resin-based composite (Tetric Flow, Ivoclar Vivadent-AG, Schaan, Liechtenstein) and finishing and polishing with sequential discs (Sof-Lex Pop-on, 3M-ESPE, St. Paul, MN, USA), the teeth were stored at 37°C and 100 percent humidity. Twenty-four hours later, half of the specimens in each group (nonbeveled “N” or beveled “B”) were exposed to a cycling loading for 250,000 cycles to simulate occlusal loading and assigned to two subgroups (NL+ or BL+), while the remainder of the specimens in each group were only maintained in a 100-percent-humidity environment, without any cyclical loading, until tested (NL– or BL–). The specimens were sealed with sticky wax (Kemdent, Associated Dental Products, Swindon, UK) and nail polish. The apical foramen of each tooth was sealed with sticky wax and the rest of the tooth was covered with nail varnish, except for an area within 1.0 mm around the composite restoration. To detect marginal leakage, all of the samples were stored in a 0.5 percent basic fuchsine solution for 24 hours. The specimens were then sectioned longitudinally using a low-speed diamond blade (IsoMet, Buehler Ltd., Lake Bluff, IL, USA), machined, and evaluated under 25X magnification using a stereomicroscope (M9, Wild Heerbrugg, Switzerland). The specimens were scored on a scale from 1 to 4 on the degree of dye penetration. The qualitative data were analyzed by the Mann- Whitney U test at a 5 percent significance level (p<0.05). The null hypothesis of this study was that there is no difference in microleakage between beveled and nonbeveled class V buccal preparations in premolar teeth restored with resinbased composite and subjected to simulated occlusal loading and thermocycling. Results In each group the gingival margin showed significantly more microleakage than the enamel margin (p<0.05). Load cycling did not result in an increase in microleakage in nonbeveled (p=0.259) or in beveled (p=0.053) occlusal margins. However, the gingival margins showed a statistically significant difference in microleakage after load cycling whether in cavities with enamel occlusal bevel (p=0.004) or in groups without a bevel. This means the enamel margin configuration of the enamel occlusal margin had no effect on decreasing microleakage in the gingival aspect of class V composite restorations. In general, the nonbeveled preparations in this study had significantly less microleakage than the bevel specimens whether they were loaded occlusally or not (p=0.001). Clinical Significance Within the limitations of this in vitro study, no benefit was derived from placing an enamel cavosurface bevel on the occlusal margin of a standardized class V composite restoration located at the cementoenamel junction. The most important consideration is to prevent microleakage along the gingival margin regardless of whether the occlusal enamel margin is beveled. Citation Ameri H, Ghavamnasiri M, Abdoli E. Effects of load cycling on the microleakage of beveled and nonbeveled occlusal margins in class V resin-based composite restorations. J Contemp Dent Pract [Internet]. 2010 October; 11(5):025- 032. Available from: http://www.thejcdp.com/ journal/view/volume11-issue5-ghavamnasiri

APA, Harvard, Vancouver, ISO, and other styles

44

Deimel, T., D. Aletaha, and G. Langs. "OP0059 AUTOSCORA: DEEP LEARNING TO AUTOMATE SCORING OF RADIOGRAPHIC PROGRESSION IN RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 39.2–40. http://dx.doi.org/10.1136/annrheumdis-2020-eular.714.

Full text

Abstract:

Background:The prevention of joint destruction is an important goal in the management of rheumatoid arthritis (RA) and a key endpoint in drug trials. To quantify structural damage in radiographs, standardized scoring systems1, such as the Sharp/van der Heijde (SvdH) score2, which separately assesses joint space narrowing (JSN) and erosions, have been developed. However, application of these scores is time-consuming, requires specially trained staff, and results are subject to considerable intra- and inter-reader variability1. This makes their application poorly feasible in clinical practice and limits their reliability in clinical trials.Objectives:We aim to develop a fully automated deep learning-based scoring system of radiographic progression in RA to facilitate the introduction of quantitative joint damage assessment into daily clinical practice and circumvent inter-reader variability in clinical trials.Methods:5191 hand radiographs and their corresponding SvdH JSN scores from 640 adult patients with RA without visible joint surgery were extracted from the picture archive of a large tertiary hospital. The dataset was split, on a patient level, into training (2207 images/270 patients), validation (1150/133), and test (1834/237) sets. Joints were automatically localized using a particular deep learning model3which utilizes the local appearance of joints combined with information on the spatial relationship between joints. Small regions of interest (ROI) were automatically extracted around each joint. Finally, different deep learning architectures were trained on the extracted ROIs using the manually assigned SvdH JSN scores as ground truth (Fig. 1). The best models were chosen based on their performance on the validation set. Their ability to assign the correct SvdH JSN scores to ROIs was assessed using the unseen data of the test set.Fig. 1.3-step approach to automated scoring: joint localization, ROI extraction, JSN scoring.Results:ROI extraction was successful in 96% of joints, meaning that all structures were visible and joints were not malrotated by more than 30 degrees. For JSN scoring, modifications of the VGG164architecture seemed to outperform adaptations of DenseNet5. The mean obtained accuracy (i.e., the percentage of joints to which the human reader and our system assigned the same score) for MCP joints was 80.5 %, that for PIP joints was 72.3 %. In only 1.8 % (MCPs) and 1.7 % (PIPs) of cases did the predicted score differ by more than one point from the ground truth (Fig. 2).Fig. 2.Confusion matrices of automatically assigned scores (‘predicted score’) vs. the human reader ground truth (‘true score’).Conclusion:Although a number of previous efforts have been published, none have succeeded in replacing manual scoring systems at scale. To our knowledge, this is the first work that utilizes a dataset of adequate size to apply deep learning to automate JSN scoring. Our results are, even in this early version, in good agreement with human reader ground truth scores. In future versions, this system can be expanded to the detection of erosions and to all joints contained in the SvdH score.References:[1]Boini, S. & Guillemin, F. Radiographic scoring methods as outcome measures in rheumatoid arthritis: properties and advantages.Ann. Rheum. Dis.60, 817–827 (2001).[2]van der Heijde, D. How to read radiographs according to the Sharp/van der Heijde method.J. Rheumatol.27, 261–263 (2000).[3]Payer, C., Štern, D., Bischof, H. & Urschler, M. Regressing Heatmaps for Multiple Landmark Localization Using CNNs. inMedical Image Computing and Computer-Assisted Intervention – MICCAI 2016230–238 (Springer, Cham, 2016). doi:10.1007/978-3-319-46723-8_27.[4]Simonyan, K. & Zisserman, A. Very Deep Convolutional Networks for Large-Scale Image Recognition.arXiv:1409.1556 [cs](2015).[5]Huang, G., Liu, Z., van der Maaten, L. & Weinberger, K. Q. Densely Connected Convolutional Networks.arXiv:1608.06993 [cs](2016).Disclosure of Interests:Thomas Deimel: None declared, Daniel Aletaha Grant/research support from: AbbVie, Novartis, Roche, Consultant of: AbbVie, Amgen, Celgene, Lilly, Medac, Merck, Novartis, Pfizer, Roche, Sandoz, Sanofi Genzyme, Speakers bureau: AbbVie, Celgene, Lilly, Merck, Novartis, Pfizer, Sanofi Genzyme, UCB, Georg Langs Shareholder of: Co-Founder/Shareholder contextflow GmbH, Grant/research support from: Grants by Novartis, Siemens Healthineers, NVIDIA

APA, Harvard, Vancouver, ISO, and other styles

45

Saini, Neeraj Y., Romil Patel, Ankur Varma, Qaiser Bashir, Ruby Delgado, Uday Popat, Chitra Hosing, et al. "Melphalan-Based Autologous Transplantation in the Octogenarian Multiple Myeloma Patient Population." Blood 132, Supplement 1 (November 29, 2018): 4608. http://dx.doi.org/10.1182/blood-2018-99-110241.

Full text

Abstract:

Abstract Abstract: Background: Upfront autologous hematopoietic stem cell transplantation (auto-HCT) combined with novel anti-myeloma drugs is considered the standard of care for transplant-eligible patients with multiple myeloma (MM). However, this treatment is generally avoided in older patients due to concerns about toxicity. MM is primarily a disease of the elderly, with >35% patients being older than 70 years of age at diagnosis. We have previously reported on the role of auto-HCT in MM patients >70 years1. In this study, we evaluate the safety and feasibility of auto-HCT in patients ≥80 years who received auto-HCT at our institution. Methods: We retrospectively reviewed the outcomes of MM patients with age ≥80 years who underwent auto-HCT between January, 2007, and June, 2018. Overall survival (OS) and progression-free survival (PFS) were calculated from the date of auto-HCT to the last follow up or the censored date. Kaplan-Meier method was used to estimate PFS and OS. Results: Between January, 2013, and December, 2017, out of a total of 1465 MM patients referred for evaluation for auto-HCT at our institution, only 10(0.68%) were of age ≥80 years. Also, between January, 2016, and June, 2018, a total of 210 MM patients with age ≥80 years were treated at our institution, and only 3(0.14%) underwent auto-HCT. Overall among 1740 patients with MM who received an auto-HCT at our institution between the beginning of 2007 to June, 2018, 9(0.5%) patients were ≥ 80 years of age (range 80-83). Table 1 summarizes the patient characteristics of these nine patients. All patients had an ECOG performance status of either 0 or 1. The median hematopoietic stem cell transplant - comorbidity index for the cohort was 3 (range, 0-5). Eight (89%) patients were in first remission, and 1 (11%) patient had relapsed disease at auto-HCT. All patients received melphalan at a reduced dose of 140 mg/m2 as the conditioning regimen. Eight patients (89%) received maintenance therapy with lenalidomide. The median follow-up from auto-HCT was 18 months (range 0.5 - 50 months). No (0%) patient died within 100 days of auto-HCT. Out of 8 evaluable patients, 4 (50%) achieved a complete response, 2 (25%) very-good partial, and 2 (25%) achieved a partial response with an overall response rate of 100%. Eight (89%) patients were alive until the last follow-up. Median PFS was 31.5 months, while the median OS has not been reached (Fig1). 2-yr PFS and OS were 62.5% and 75% respectively. One patient died 22 months post-transplant due to non-transplant related cause. Conclusions: In selected MM patients ≥80 years old, auto-HCT was feasible, with 0% TRM, 100% response rate, and 2-year OS of 75%. Almost 90% of these patients went on to receive maintenance therapy. References: Qazilbash, M. H. et al. Autologous stem cell transplantation is safe and feasible in elderly patients with multiple myeloma. Bone Marrow Transplantation39, 279-283 (2007). Disclosures Shpall: Affirmed GmbH: Research Funding. Thomas:Celgene: Research Funding; Array Pharma: Research Funding; Acerta Pharma: Research Funding; Amgen Inc: Research Funding; Bristol Myers Squibb Inc.: Research Funding. Lee:Celgene: Consultancy, Membership on an entity's Board of Directors or advisory committees; Adaptive Biotechnologies Corporation: Consultancy; Amgen: Consultancy, Membership on an entity's Board of Directors or advisory committees; Chugai Biopharmaceuticals: Consultancy; Takeda Oncology: Consultancy, Membership on an entity's Board of Directors or advisory committees; Kite Pharma: Consultancy, Membership on an entity's Board of Directors or advisory committees. Patel:Poseida Therapeutics, Inc.: Research Funding; Takeda: Research Funding; Abbvie: Research Funding; Celgene: Research Funding. Orlowski:Amgen: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Millenium Pharmaceuticals: Consultancy, Research Funding; BioTheryX, Inc: Consultancy, Membership on an entity's Board of Directors or advisory committees; Poseida: Research Funding; Bristol Myers Squibb: Consultancy; Celgene: Consultancy, Membership on an entity's Board of Directors or advisory committees; Janssen Pharmaceuticals: Consultancy, Membership on an entity's Board of Directors or advisory committees; Genentech: Consultancy. Champlin:Otsuka: Research Funding; Sanofi: Research Funding.

APA, Harvard, Vancouver, ISO, and other styles

46

Emme, Ingo, Stefan Redlich, Thomas Labahn, Jörg Magull, and Armin de Meijere. "Tetra- and Pentacyclopropylcyclopentadiene—Two New Donor-Substituted Ligands for Metal Complexes Small Ring Building Blocks in Organic Synthesis: Part 74. This work was supported by the Fonds der Chemischen Industrie as well as the companies BASF AG and Chemetall GmbH (Chemicals). The authors are indebted to Prof. Burkhard König, Regensburg (Germany) and Prof. Pierre H. Dixneuf, Rennes (France), for measuring the oxidation potentials of the new ferrocenes, as well as to Dr. Burkhard Knieriem, Göttingen, for his careful proofreading of the final manuscript. Part 73: H. Nüske, M. Noltemeyer, A. de Meijere, Angew. Chem. 2001, 3509–3511; Angew. Chem. Int. Ed. 2001, 40, 3411–3413. Part 72: A. de Meijere, M. von Seebach, S. I. Kozhushkov, S. Cicchi, T. Dimoulas, A. Brandi, Eur. J. Org. Chem. 2001, 3789–3795." Angewandte Chemie International Edition 41, no. 5 (March 1, 2002): 786. http://dx.doi.org/10.1002/1521-3773(20020301)41:5<786::aid-anie786>3.0.co;2-7.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

Nguyet, Nguyen Thi Anh, Nguyen Thuy Duong, Arndt Schimmelmann, and Nguyen Van Huong. "Human exposure to radon radiation geohazard in Rong Cave, Dong Van Karst Plateau Geopark, Vietnam." VIETNAM JOURNAL OF EARTH SCIENCES 40, no. 2 (January 19, 2018): 117–26. http://dx.doi.org/10.15625/0866-7187/40/2/11092.

Full text

Abstract:

Rong Cave is one of the more important caves in northern Vietnam’s Dong Van Karst Plateau Geopark (part of the Global Geoparks Network), because its subterranean lake provides agricultural and domestic water for neighboring communities. Maintenance and utilization of Rong Cave’s water reservoir, as well as touristic cave use, require frequent human access to Rong Cave. Depending on the availability of seasonal drip water and the water level of the lake, the abundant clay-rich sediment in the back portion of Rong Cave and possible seepage of gas from deeper strata along geologic faults provide seasonally elevated concentrations of radon in cave air. Based on repeated measurements over 10 months in 2015 and 2016 of the concentrations of radon isotopes (222Rn and 220Rn, also called thoron) with a portable SARAD® RTM 2200 instrument (SARAD® GmbH, Germany), the human total annual inhalation dose was estimated according to the UNSCEAR (2000) algorithm. The result indicates that the radon-related radiation exposure is insignificant for short-term visitors but may reach ~1.8 mSv a-1 for tour guides and ~25 mSv a-1 for cave utility workers. The latter values exceed the IAEA-recommended safety threshold of 1 mSv a-1 (IAEA, 1996). We recommend radiation monitoring for cave utility workers and tour guides. Prolonged human presence in Rong Cave should be avoided during periods of seasonally elevated radon concentrations.References Cigna A.A., 2005. Radon in caves. Interna-tional Journal of Speleology 34(1-2), 1-18. Ha Giang Statistics Office (GSO), 2016. Statistical Yearbook of Ha Giang 2015, 404 pages, Ha Giang (in Vietnamese). Dumitru O.A., Onac B.P., Fornós J.J., Cosma C., Ginés A., Ginés J., Merino A., 2015. Radon survey in caves from Mallorca Island, Spain. Science of The Total Environment, 526, 196-203. Etiope G., Martinelli G., 2002. Migration of carrier and trace gases in the geosphere: An overview. Physics of the Earth and Planetary Interiors, 129(3-4), 185-204. Global Geoparks Network (GGN), 2010. Dong Van Karst Plateau Geopark. http://www.globalgeopark.org/aboutggn/list/vietnam/6509.htm Gregorič A., Vaupotič J., Šebela S., 2013. The role of cave ventilation in governing cave air temperature and radon levels (Postojna Cave, Slovenia). International Journal of Climatology 34, 1488-1500. Gunn J., 2003. Radon in caves. In Gunn J (Ed.): Encyclopedia of Caves and Karst Science. Fitzroy Dearborn (Taylor & Francis Books, Inc.), London, UK, 617-619. International Atomic Energy Agency (IAEA), 1996. Quality assurance for safety in nuclear power plants and other nuclear installations. Safety standards and guides, In: Safety series Q1-Q14. A publication within the Nuss programme. International Commission on Radiological Protection (ICRP), 2003. Database of Dose Coefficients: Workers and Members of the Public, Version 2.0.1 (CD- ROM), Elsevier Science, Amsterdam. International Commission on Radiological Protection (ICRP), 2010. Lung cancer risk from radon and progeny and Statement of radon. ICPR Pub. 115. Ann. ICPR 40(1). Markkanen M., Arvela H., 1992. Radon emanation from soils. Radiation Protection Dosimetry, 45(1-4), 269-272. Meisenberg O., Mishra R., Joshi M., Gierl S., Rout R., Guo L., Agaarwwal T., Kanse S., Irlinger J., Sapra B.K., Tschiersch J., 2017. Radon and thoron inhalation doses in dwellings with earthen architecture: Comparison of measurement methods. Science of The Total Environment, 579, 1855-1862. Morawska L., Phillips C.R., 1993. Depend-ence of the radon emanation coefficient on radium distribution and internal structure of the material, Geochimica et Cosmochimica Acta, 57(8), 1783-1797. Nguyen Thuy Duong, Nguyen Van Huong, Arndt Schimmelmann, Nguyen Thi Anh Nguyet, Dang Thi Phuong Thao, Ta Hoa Phuong, 2016. Radon concentrations in karst caves in Dong Van karst plat-eau. VNU Journal of Science - Earth and Environmental Sciences, 32(2S), 187-197 (in Vietnamese). Nguyen Thuy Duong, Arndt Schimmelmann, Nguyen Van Huong, Agnieszka Drobniak, Jay T. Lennon, Ta Hoa Phuong, Nguyen Thi Anh Nguyet, 2017. Subterranean microbial oxidation of atmospheric methane in cavernous tropical karst. Chemical Ge-ology, 466, 229-238. Nguyen Van Huong, Nguyen Thuy Duong, Nguyen Thi Anh Nguyet, Pham Nu Quynh Nhi, Dang Thi Phuong Thao, Tran Van Phong, Nguyen Ngoc Anh, 2016. Cenozoic tectonics in Dong Van karst plateau recorded in karst cave system. VNU Journal of Science - Earth and Environmental Sciences, 32(2S), 45-58 (in Vietnamese). Nguyen Anh Nguyet, Nguyen Thuy Dương, Arndt Schimmelmann, Nguyen Van Hu-ong, Ta Hoa Phuong, Dang Phuong Thao, Ma Ngoc Giang, 2016. Radon concentration in Rong cave in Dong Van Karst Plateau Geopark. Proceeding of International Symposium Hanoi Geoengineering 2016, 248-253. The United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR), 1993. Report to the General Assembly, with scientific annexes. United Nations sales publication E.94.IX.2. United Nations, New York. The United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR), 2000. UNSCEAR 2000 Report. In: Sources, vol. I. United Nations, New York. The United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR), 2008. UNSCEAR 2000 Report. In: Sources, vol. I. United Nations, New York. Vietnamese Standards (TCVN 7889:2008), 2008. Natural Radon activity in buildings-Levels and general requirements of measuring methods, Ministry of Science and Technology and Ministry of Construction (Viet Nam) (in Vietnamese). Tong-Dzuy Thanh, Vu Khuc (Eds), 2011. Stratigraphic units of Vietnam. Vietnam National University Publisher, 553p. Walia V., Lin S.J., Fu C.C., Yang T.F., Hong W.L., Wen K.L., Chen C.H., 2010. Soil-gas monitoring: A tool for fault delineation studies along Hsinhua Fault (Tainan), Southern Taiwan. Applied Geochemistry, 25(4), 602-607. Wang J., Meisenberg O., Chen Y., Karg E., Tschiersch J., 2011. Mitigation of radon and thoron decay products by filtration. Science of The Total Environment, 409(19), 3613-3619. World Health Organization (WHO), 2000. Air Quality Guidelines for Europe, (2nd edition). WHO Regional Publications, European Series, 91, Chapter 8.3 - Radon.

APA, Harvard, Vancouver, ISO, and other styles

48

Izadi, Z., M. Gianfrancesco, K. Hyrich, A. Strangfeld, L. Gossec, L. Carmona, E. Mateus, et al. "OP0288 MACHINE LEARNING ALGORITHMS TO PREDICT COVID-19 ACUTE RESPIRATORY DISTRESS SYNDROME IN PATIENTS WITH RHEUMATIC DISEASES: RESULTS FROM THE GLOBAL RHEUMATOLOGY ALLIANCE PROVIDER REGISTRY." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 175.2–176. http://dx.doi.org/10.1136/annrheumdis-2021-eular.446.

Full text

Abstract:

Background:Acute Respiratory Distress Syndrome (ARDS) is a life-threatening complication of COVID-19 and has been reported in approximately one-third of hospitalized patients with COVID-191. Risk factors associated with the development of ARDS include older age and diabetes2. However, little is known about factors associated with ARDS in the setting of COVID-19, in patients with rheumatic disease or those receiving immunosuppressive medications. Prediction algorithms using traditional regression methods perform poorly with rare outcomes, often yielding high specificity but very low sensitivity. Machine learning algorithms optimized for rare events are an alternative approach with potentially improved sensitivity for rare events, such as ARDS in COVID-19 among patients with rheumatic disease.Objectives:We aimed to develop a prediction model for ARDS in people with COVID-19 and pre-existing rheumatic disease using a series of machine learning algorithms and to identify risk factors associated with ARDS in this population.Methods:We used data from the COVID-19 Global Rheumatology Alliance (GRA) Registry from March 24 to Nov 1, 2020. ARDS diagnosis was indicated by the reporting clinician. Five machine learning algorithms optimized for rare events predicted ARDS using 42 variables covering patient demographics, rheumatic disease diagnoses, medications used at the time of COVID-19 diagnosis, and comorbidities. Model performance was assessed using accuracy, area under curve, sensitivity, specificity, positive predictive value, and negative predictive value. Adjusted odds ratios corresponding to the 10 most influential predictors from the best performing model were derived using hierarchical multivariate mixed-effects logistic regression that accounted for within-country correlations.Results:A total of 5,931 COVID-19 cases from 67 countries were included in the analysis. Mean (SD) age was 54.9 (16.0) years, 4,152 (70.0%) were female, and 2,399 (40.5%) were hospitalized. ARDS was reported in 388 (6.5% of total and 15.6% of hospitalized) cases. Statistically significant differences in the risk of ARDS were observed by demographics, diagnoses, medications, and comorbidities using unadjusted univariate comparisons (data not shown). Gradient boosting machine (GBM) had the highest sensitivity (0.81) and was considered the best performing model (Table 1). Hypertension, interstitial lung disease, kidney disease, diabetes, older age, glucocorticoids, and anti-CD20 monoclonal antibodies were associated with the development of ARDS while tumor necrosis factor inhibitors were associated with a protective effect (Figure 1).Table 1.Performance of machine learning algorithms.GBMSVMGLMNETNNETRFAccuracy0.790.680.660.660.67AUC0.750.700.740.580.74Sensitivity0.810.680.650.680.67Specificity0.490.600.730.480.68PPV0.960.960.970.950.97NPV0.160.120.130.090.13GBM: Gradient Boosting Machine, SVM: Support vector machines, GLMNET: Lasso and Elastic-Net Regularized Generalized Linear Models, NNET: Neural Networks, RF: Random Forest. AUC: Area Under Curve; PPV: Positive Predictive Value; NPV: Negative Predictive Value.Conclusion:In this global cohort of patients with rheumatic disease, a machine learning model, GBM, predicted the onset of ARDS with 81% sensitivity using baseline information obtained at the time of COVID-19 diagnosis. These results identify patients who may be at higher risk of severe COVID-19 outcomes. Further studies are necessary to validate the proposed prediction model in external cohorts and to evaluate its clinical utility. Disclaimer: The views expressed here are those of the authors and participating members of the COVID-19 Global Rheumatology Alliance, and do not necessarily represent the views of the ACR, NIH, (UK) NHS, NIHR, or the department of Health.References:[1]Tzotzos SJ, Fischer B, Fischer H, Zeitlinger M. 2020;24(1):516.[2]Wu C, Chen X, Cai Y, et al. JAMA Intern Med. 2020;180(7):934-943.Acknowledgements:The COVID-19 Global Rheumatology Alliance.Disclosure of Interests:Zara Izadi: None declared, Milena Gianfrancesco: None declared, Kimme Hyrich Speakers bureau: Abbvie and grant income from BMS, UCB, and Pfizer, all unrelated to this study., Anja Strangfeld Speakers bureau: AbbVie, MSD, Roche, BMS, Pfizer, outside the submitted work., Grant/research support from: A consortium of 13 companies (among them AbbVie, BMS, Celltrion, Fresenius Kabi, Lilly, Mylan, Hexal, MSD, Pfizer, Roche, Samsung, Sanofi-Aventis, and UCB) supporting the German RABBIT register., Laure Gossec Consultant of: Abbvie, Biogen, Celgene, Janssen, Lilly, Novartis, Pfizer, Sanofi-Aventis, UCB., Grant/research support from: Lilly, Mylan, Pfizer, all unrelated to this study., Loreto Carmona Consultant of: Loreto Carmona’s institute works by contract for laboratories among other institutions, such as Abbvie Spain, Eisai, Gebro Pharma, Merck Sharp & Dohme España, S.A., Novartis, Farmaceutica, Pfizer, Roche Farma, Sanofi Aventis, Astellas Pharma, Actelion Pharmaceuticals España, Grünenthal GmbH, and UCB Pharma., Elsa Mateus Grant/research support from: LPCDR received grants from Abbvie, Novartis, Janssen-Cilag, Lilly Portugal, Sanofi, Grünenthal S.A., MSD, Celgene, Medac, Pharmakern, GAfPA and Pfizer., Saskia Lawson-Tovey: None declared, Laura Trupin: None declared, Stephanie Rush: None declared, Gabriela Schmajuk: None declared, Lindsay Jacobsohn: None declared, Patti Katz: None declared, Samar Al Emadi: None declared, Leanna Wise: None declared, Emily Gilbert: None declared, Maria Valenzuela-Almada: None declared, Ali Duarte-Garcia: None declared, Jeffrey Sparks Consultant of: Bristol-Myers Squibb, Gilead, Inova, Janssen, and Optum unrelated to this work., Grant/research support from: Amgen and Bristol-Myers Squibb., Tiffany Hsu: None declared, Kristin D’Silva: None declared, Naomi Serling-Boyd: None declared, Suleman Bhana Employee of: Suleman Bhana reports non-branded marketing campaigns for Novartis (<$10,000)., Wendy Costello: None declared, Rebecca Grainger Speakers bureau: Abbvie, Janssen, Novartis, Pfizer, Cornerstones and travel assistance from Pfizer (all < $10,000)., Jonathan Hausmann Consultant of: Novartis, unrelated to this work (<$10,000)., Jean Liew Grant/research support from: Pfizer, outside the submitted work., Emily Sirotich Grant/research support from: Emily Sirotich is a Board Member of the Canadian Arthritis Patient Alliance, a patient run, volunteer-based organization whose activities are largely supported by independent grants from pharmaceutical companies., Paul Sufka: None declared, Zachary Wallace Consultant of: Viela Bio and MedPace, outside the submitted work., Grant/research support from: Bristol-Myers Squibb and Principia/Sanofi., Pedro Machado Speakers bureau: Abbvie, BMS, Celgene, Eli Lilly, Janssen, MSD, Novartis, Pfizer, Roche and UCB, all unrelated to this study (all < $10,000)., Philip Robinson Consultant of: Abbvie, Eli Lilly, Janssen, Novartis, Pfizer and UCB and travel assistance from Roche (all < $10,000)., Jinoos Yazdany Consultant of: Eli Lilly and Astra Zeneca, unrelated to this project.

APA, Harvard, Vancouver, ISO, and other styles

49

Abonyi, A., and I. Grigorszky. "Book reviewsDas, D. and Keshri, J. P. (2016): Desmids of Eastern Himalaya. — Bibliotheca Phycologica, Vol. 119, J. Cramer in der Gebrüder Borntraeger Verlagsbuchhandlung, Stuttgart, 260 pp. (ISBN 978-3-443-60046-4).Liska, I. (ed.) (2015): The Danube River Basin. — In: Barceló, D. and Kostianoy, A. G. (eds.): The Handbook of Environmental Chemistry. Vol. 39. Springer-Verlag GmbH, Berlin, Heidelberg, Germany, 523 pp. (ISBN 978-3-662-47738-0).Miscoe, L. H., Johansen, J. R., Kociolek, J. P., Lowe, R. L., Vaccarino, M. A., Pietrasiak, N. and Sherwood, A. R. (2016): The diatom flora and cyanobacteria from caves on Kauai, Hawaii. — Bibliotheca Phycologica, Vol. 120, J. Cramer in der Gebrüder Borntraeger Verlagsbuchhandlung, Stuttgart, 152 pp. (ISBN 978-3-443-60047-1)." Acta Botanica Hungarica 58, no. 3-4 (September 2016): 447–48. http://dx.doi.org/10.1556/abot.58.2016.3-4.14.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Jung, S., A. Bosch, D. Kannenkeril, M. Karg, K. Striepe, P. Bramlage, C. Ott, and R. E. Schmieder. "1416Combined therapy of empagliflozin and linagliptin is superior to metformin and insulin glargine in improving blood pressure and vascular function in type 2 diabetes." European Heart Journal 40, Supplement_1 (October 1, 2019). http://dx.doi.org/10.1093/eurheartj/ehz748.0063.

Full text

Abstract:

Abstract Background and purpose The optimal choice of antidiabetic medication in patients that need combined therapy is under debate. The aim of this study was to analyze whether beyond glucose control the combination of empagliflozin (E) and linagliptin (L) improves blood pressure (BP) and vascular function in patients with type 2 diabetes (T2DM) as opposed to the combination of metformin (M) and insulin glargine (I). Methods This was a prospective, randomized, controlled, single center study including 101 patients with T2DM, who were randomized 1:1 to E 10–25mg combined with L 5mg once daily or M 850 or 1000mg twice daily combined with I once daily. All patients underwent BP measurement and vascular function analysis by validated systems at baseline and after 12 weeks of treatment. Results In comparison to baseline, office, 24-hour ambulatory BP as well as central blood and pulse pressure (PP) values decreased significantly after 12 weeks of treatment with E+L, whereas there was no change in the M+I group (see table). Twenty-four-hour peripheral systolic (mean difference: −5.2±1.5mmHg, p=0.004) and diastolic BP (−1.9±1.0mmHg, p=0.036), central clinical systolic BP (−5.56±1.9mmHg, p=0.009), forward pressure pulse height (−2.0±0.9mmHg, p=0.028), 24-h central systolic BP (−3.6±1.4mmHg, p=0.045) and 24-h pulse wave velocity (−0.14±0.05m/s, p=0.043) were reduced to a greater extent in the E+L than in the M+I group. Empagliflozin+Linagliptin Metformin+Insulin Baseline 12 weeks p value Baseline 12 weeks p value Peripheral ambulatory BP values 24-h SBP [mmHg] 131.0±10.9 127.0±8.8 <0.001 131.0±9.7 131.0±8.6 0.438 24-h DBP [mmHg] 81.5±7.1 79.7±7.0 0.013 81.0±7.1 81.0±7.5 0.976 Clinical (laboratory) central vascular parameters Central SBP [mmHg] 123.0±9.6 117.0±10.4 <0.001 121.0±9.9 121.0±8.3 0.944 Central PP [mmHg] 44.4±8.0 41.4±6.6 0.004 43.5±8.6 42.8±7.5 0.471 Forward pressure pulse height [mmHg] 33.0±5.7 30.2±4.6 <0.001 32.5±5.6 31.8±4.5 0.216 Central office PWV [m/s] 8.2±1.6 8.0±1.5 0.039 8.4±1.3 8.3±1.2 0.400 24-h ambulatory central vascular parameters Central 24-h SBP [mmHg] 120.5±9.3 117.3±7.9 0.007 121.0±9.1 121.0±8.0 0.608 Central 24-h DBP [mmHg] 83.2±7.3 81.1±6.9 0.016 82.4±7.1 82.4±7.7 0.928 Central 24-h PWV [m/s] 8.9±1.3 8.8±1.3 0.010 9.0±1.4 9.0±1.3 0.349 SBP, systolic blood pressure; DBP, diastolic blood pressure; PP, pulse pressure; PWV, pulse wave velocity. Conclusion The combination of E+L significantly improves BP and vascular function in contrast to the combination of M+I. Acknowledgement/Funding This IIS was supported by a research grant from Boehringer Ingelheim International GmBH

APA, Harvard, Vancouver, ISO, and other styles

Journal articles on the topic 'H.M. Hauschild GmbH'

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles