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Journal articles on the topic 'H. pylori therapy'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

I.M., Saracino, Pavoni M., Zullo A., et al. "Antibiotic Resistance and Therapy Outcome in H. pylori Eradication Failure Patients." Antibiotics 9, no. 3 (2020): 121. http://dx.doi.org/10.3390/antibiotics9030121.

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Helicobacter pylori (H. pylori) eradication fails in a definite amount of patients despite one or more therapeutic attempts. Curing these patients is progressively more difficult, due to development of antibiotic resistance. Current guidelines suggest testing antibiotic susceptibility in H. pylori isolates following two therapeutic attempts. Aim: to evaluate the development of antibiotic resistance, MIC values trends and therapeutic outcomes in patients who failed at least one H. pylori eradication therapy. Methods: consecutive patients, referred to perform upper gastrointestinal endoscopy (UG

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Fiorini, Giulia, Ilaria Maria Saracino, Angelo Zullo, et al. "Antibiotic Resistance and Therapy for H. pylori Infection in Immigrant Patients Treated in Italy." Journal of Clinical Medicine 9, no. 5 (2020): 1299. http://dx.doi.org/10.3390/jcm9051299.

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Background: Helicobacter pylori (H. pylori) infection is the leading cause of both peptic ulcers and gastric tumors, including low-grade MALT-lymphoma and adenocarcinoma. Although it is decreasing in developed countries, H. pylori prevalence remains high in developing areas, mainly due to low socio-economic levels, and the potential consumption of contaminated water. Moreover, a different pattern of primary antibiotic resistance is expected in their H. pylori isolates, potentially affecting the efficacy of standard eradication therapies. Indeed, a previous study showed the eradication rate fol

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&NA;. "Anti-H. pylori therapy." Inpharma Weekly &NA;, no. 1148 (1998): 13. http://dx.doi.org/10.2165/00128413-199811480-00023.

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Di Ciaula, Agostino, Giuseppe Scaccianoce, Marino Venerito, et al. "Eradication Rates in Italian Subjects Heterogeneously Managed for Helicobacter pylori Infection. Time to Abandon Empiric Treatments in Southern Europe." Journal of Gastrointestinal and Liver Diseases 26, no. 2 (2017): 129–37. http://dx.doi.org/10.15403/jgld.2014.1121.262.itl.

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Background & Aims: H. pylori eradication is strongly affected by various factors, including the ongoing antibiotic resistance. We describe a “real life” scenario in patients managed for H. pylori-related conditions, living in a southern Italian region (Apulia), an area with clarithromycin resistance >15%.Methods: 2,224 subjects were studied in two tertiary referral centers in Apulia. Analyses included: reason for referral, H. pylori infection rates (13C-urea breath test – UBT or upper endoscopy), and eradication rates following distinct regimens previously prescribed or prospectively pr

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Zullo, Angelo, Vincenzo De Francesco, Annamaria Bellesia, et al. "Bismuth-based Quadruple Therapy Following H. pylori Eradication Failures: a Multicenter Study in Clinical Practice." Journal of Gastrointestinal and Liver Diseases 26, no. 3 (2017): 225–29. http://dx.doi.org/10.15403/jgld.2014.1121.263.zul.

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Background & Aims: Helicobacter pylori (H. pylori) eradication in patients who failed one or more therapeutic attempts remains challenging. This study aimed to assess the efficacy of three-in-one capsules bismuth-based quadruple therapy (Pylera®) in these patients managed in clinical practice. Methods: This was a prospective, open-label, multicenter study enrolling consecutive, adult patients with persistent H. pylori infection following at least one standard therapy. All patients received a rescue quadruple therapy with Pylera (3 capsules four times daily) and esomeprazole 20 mg (1

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Hartanto, Darius. "Helicobacter pylori Infection: Diagnosis and Therapy." Asian Journal of Medical Sciences 12, no. 4 (2021): 145–48. http://dx.doi.org/10.3126/ajms.v12i4.34506.

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Helicobacter pylori (H. pylori) is a spiral shape gram-negative bacillus and have flagella for motility in mucus environment. H. pylori is microaerophilic organism, slow growing and requires complex growth media in vitro. H. pylori infecting more than 50% populations in worldwide. Prevalence of H. pylori infection is higher in developing countries compared to developed one, and indicates that socioeconomic and living standard may play a major role in the distribution. This study aims to provide an overview of how to diagnose and manage Helicobacter pylori infection. This study reviewed various

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Darius Hartanto. "Helicobacter pylori Infection: Diagnosis and Therapy." Asian Journal of Medical Sciences 12, no. 4 (2021): 145–48. https://doi.org/10.71152/ajms.v12i4.3582.

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Helicobacter pylori (H. pylori) is a spiral shape gram-negative bacillus and have flagella for motility in mucus environment. H. pylori is microaerophilic organism, slow growing and requires complex growth media in vitro. H. pylori infecting more than 50% populations in worldwide. Prevalence of H. pylori infection is higher in developing countries compared to developed one, and indicates that socioeconomic and living standard may play a major role in the distribution. This study aims to provide an overview of how to diagnose and manage Helicobacter pylori infection. This study reviewed various

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Eissa, Adil, and Saad Mirza. "The Relevance of Helicobacter pylori Infection to Iron Deficiency Anemia in Duhok City." Iraqi Journal of Medical Sciences 19, no. 1 (2021): 33–38. http://dx.doi.org/10.22578/ijms.19.1.5.

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Background:Helicobacter pylori (H. pylori) infection had been criticized for many deleterious effects and had been amalgamated to iron deficiency by many authors, frequently based on correlative rather than direct relationship studies and often opposed by others. Objective: To evaluate the role of H. pylori infection in the etiology of iron deficiency anemia and to study the impact of the bacterial eradication on the response to iron therapy. Methods:The current study represents an interventional prospective study and involved 52 non-pregnant females with iron deficiency anemia. All patients w

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De Francesco, Vincenzo, Angelo Zullo, Luigi Gatta, et al. "Rescue Therapies for H. pylori Infection in Italy." Antibiotics 10, no. 5 (2021): 525. http://dx.doi.org/10.3390/antibiotics10050525.

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Background/Aims: Curing Helicobacter pylori infection remains challenging for clinicians, as no proposed first-line therapy achieves bacterial eradication in all treated patients so that several patients need two or more consecutive treatments. Bacterial culture with antibiotics susceptibility testing is largely unachievable in Italy, and empiric second-line and rescue therapies are generally used. This study aimed to identify what eradication regimens perform better in Italy, following first-line therapy failure. Methods: We performed a literature search on PubMed for studies on standard ther

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Tongtawee, Taweesak, Wareeporn Wattanawongdon, and Theeraya Simawaranon. "Effects of periodontal therapy on eradication and recurrence of Helicobacter pylori infection after successful treatment." Journal of International Medical Research 47, no. 2 (2019): 875–83. http://dx.doi.org/10.1177/0300060518816158.

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Objectives This study aimed to evaluate the effects of periodontal therapy on the efficacy of Helicobacter pylori eradication and on the recurrence of infection after eradication. Methods We conducted a prospective randomized trial on 698 gastric H. pylori-infected patients, of whom 347 received gastric H. pylori treatment alone and 342 received gastric H. pylori treatment plus periodontal therapy. The presence of H. pylori and associated virulence genes were detected by real-time polymerase chain reaction. Results After eradication of gastric H. pylori infection, the recurrence of gastric H.

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Rosania, Rosa, Ulrike Von Arnim, Alexander Link, et al. "Helicobacter Pylori Eradication Therapy is Not Associated with the Onset of Inflammatory Bowel Diseases. A Case-Control Study." Journal of Gastrointestinal and Liver Diseases 27, no. 2 (2018): 119–25. http://dx.doi.org/10.15403/jgld.2014.1121.272.hpy.

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Background & Aims: A negative association between H. pylori and inflammatory bowel disease (IBD) has been previously reported. There were also case reports suggesting a new onset of IBD 6-12 months after H. pylori eradication therapy. In a case-control study we investigated whether previous H. pylori eradication therapy was associated with the risk of developing IBD.Methods: IBD outpatients with both Crohn´s disease (CD) and ulcerative colitis (UC) were enrolled. Age- and sex-matched blood donors served as controls in a 1:2 fashion. Information on demographics, medical history, previous H.

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BOCIAN, KATARZYNA M., and ELŻBIETA K. JAGUSZTYN-KRYNICKA. "The Controversy over Anti-Helicobacter pylori Therapy." Polish Journal of Microbiology 61, no. 4 (2012): 239–46. http://dx.doi.org/10.33073/pjm-2012-033.

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Helicobacter pylori is a Gram-negative spiral-shaped bacterium, member of epsilon-Proteobacteria specifically colonizing the gastric epithelium of humans. It causes one of the most common infections worldwide, affecting about half of the world's population. However, it should be noted that the prevalence of H. pylori, particularly in the Western world, has significantly decreased coinciding with an increase of some autoimmune and allergic diseases, such as asthma. Various epidemiological studies have also documented a negative association between H. pylori colonization and the presence of GERD

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Namiot, DB, K. Leszczyńska, A. Namiot, et al. "The influence of Helicobacter pylori eradication therapy on the presence of H. pylori antigens in dental plaque and saliva." Progress in Health Sciences 6, no. 1 (2016): 19–24. http://dx.doi.org/10.5604/01.3001.0009.5016.

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Purpose: The aim of this study was to evaluate the presence of H. pylori antigens in the oral cavity (dental plaque and saliva) of patients undergoing systemic eradication therapy. Materials and methods: The study was conducted in 49 subjects with H. pylori stomach infection. H. pylori antigens in dental plaque and saliva were evaluated with immunological method. Results: In subjects with initial H. pylori oral infection, the presence of H. pylori antigens in the oral cavity 6 weeks after successful or unsuccessful H. pylori eradication therapy in the stomach was 47.0% and 50.0%, respectively.

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Thomson, Alan B. R. "Therapy for H. pylori infection." Current Gastroenterology Reports 1, no. 6 (1999): 518–23. http://dx.doi.org/10.1007/s11894-999-0013-7.

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Slomski, Anita. "Novel Therapy Eradicates H pylori." JAMA 324, no. 4 (2020): 327. http://dx.doi.org/10.1001/jama.2020.12592.

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Hana, Mumtaz K. "Prevalence of H pylori in obese attending Obesity therapy Unit." AL-Kindy College Medical Journal 13, no. 2 (2019): 69–71. http://dx.doi.org/10.47723/kcmj.v13i2.98.

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Background: Obesity is an increasing health problem in developed countries and has grown into a major global epidemic. Recent studies suggested colonization of the stomach by Hpylori might affect gastric expression of appetite- and satiety-related hormone and patients cured of H pylori infection gained weight. Obesity and Helicobacter pylori (H. pylori) are important because of the problems they lead and their frequency of occurrence. Objectives: To find out the prevalence of H. pylori infection in obese. Type of the study:A cross-sectional study Methods: A total of 32 obese

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Park, Chan Hyuk. "Helicobacter pylori Eradication and Gastric Cancer Prevention." Korean Journal of Helicobacter and Upper Gastrointestinal Research 21, no. 4 (2021): 267–74. http://dx.doi.org/10.7704/kjhugr.2021.0044.

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Since Warren and Marshall demonstrated Helicobacter pylori (H. pylori) as a cause of gastritis in the early 1980s, H. pylori has been associated with various gastric diseases, including gastric ulcer, gastric mucosa-associated lymphoid tissue (MALT) lymphoma, gastric adenoma, gastric adenocarcinoma, and hyperplastic gastric polyps. H. pylori eradication therapy can treat some associated diseases, including low-grade gastric MALT lymphoma, and significantly reduce the risk of peptic ulcer recurrence or progression of atrophic gastritis and intestinal metaplasia. In East Asia, where H. pylori an

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Saito, Yoshimasa, Kaho Konno, Moeka Sato, et al. "Vonoprazan-Based Third-Line Therapy Has a Higher Eradication Rate against Sitafloxacin-Resistant Helicobacter pylori." Cancers 11, no. 1 (2019): 116. http://dx.doi.org/10.3390/cancers11010116.

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Eradication of Helicobacter pylori (H. pylori) is an effective strategy for preventing various gastrointestinal diseases such as gastric cancer and mucosa-associated lymphoid tissue (MALT) lymphoma. However, the eradication success rate is decreasing because of a recent increase in drug-resistant strains of H. pylori. Here, we evaluated the success rate of eradication therapy with vonoprazan (VPZ), a new potassium-competitive acid blocker, against drug-resistant H. pylori. In total, 793 patients who received H. pylori eradication therapy were investigated retrospectively. All underwent esomepr

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Kandyil, Roshini, Nadia S. Satya, and Robert A. Swerlick. "Chronic Pruritus Associated with Helicobacter Pylori." Journal of Cutaneous Medicine and Surgery 6, no. 2 (2002): 103–8. http://dx.doi.org/10.1177/120347540200600202.

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Background: Helicobacter pylori is an established cause of gastritis and has been implicated in extradigestive diseases. Objective: To investigate the role of H. pylori in patients with unexplained refractory pruritus. Methods: Ten patients with severe pruritus unresponsive to conventional therapy were evaluated for active H. pylori infection by H. pylori serology followed by either esophagogastroduodenoscopy (EGD) or urea breath test. Of the 10 patients, 8 were found to have active infection. All 10 received anti- H. pylori antibiotic therapy and were reevaluated for relief of pruritus. Resul

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Husain, Arif, and Shrish Bhatnagar. "Does H. pylori therapy augments the effect of iron therapy among children with iron deficiency anemia?" International Journal of Contemporary Pediatrics 7, no. 4 (2020): 831. http://dx.doi.org/10.18203/2349-3291.ijcp20201139.

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Background: To assess beneficial effects of H. pylori therapy on children with pre-existing Iron Deficiency Anemia (IDA).Methods: A total of 218 consecutive patients with iron deficiency anemia (Hb 6-11 gm/dl) were invited to participate in the study. Patients underwent endoscopic biopsy and rapid urease test for H. pylori detection. A total of three groups were formed- Group I (n=13) - positive for H. pylori, underwent treatment for H. pylori therapy and IDA, Group II (n=16) - positive for H. pylori, underwent treatment for IDA only, Group III (n=101) - negative for H. pylori, underwent treat

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Rongli, Cui, and Zhou Liya. "Helicobacter pylori infection: an overview in 2013, focus on therapy." Chinese Medical Journal 127, no. 3 (2014): 568–73. http://dx.doi.org/10.3760/cma.j.issn.0366-6999.20132708.

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Objective This article aimed to review the incidence of Helicobacter pylori (H. pylori) infection and its therapy. Data sources Relevant articles published in English were identified by searching in PubMed from 2000 to 2013, with keywords “H. pylori”. Important references from selected articles were also retrieved from Elsevier, Wiley, EBSCO, and SPRINGER. The Chinese articles published were searched from China National Knowledge Infrastructure (CNKI). Study selection Articles about “prevalence”, “gastric carcinoma”, “peptic ulcer”, “gastroesophageal reflux disease”, “functional dyspepsia”, “p

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Thuan, Nguyen Thi Minh, and Luong Thi Ha Vi. "Effcacy of quadruple therapy for the treatment of H. pylori infection at Gia Dinh people’s hospital." Tạp chí Y học Dự phòng 30, no. 4 (2021): 12–19. http://dx.doi.org/10.51403/0868-2836/2020/244.

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Helicobacter pylori (H. pylori) infection is one of the most common chronic bacterial infections in the world. For the purpose of eradicating H. pylori, quadruple therapies are widely prescribed in patients infected with H. pylori. According to the Maastricht V Consensus Conference, in regions where the rate of resistance of H. pylori to CLR and MTZ is high such as Viet Nam, bismuth quadruple therapy is the first choice. However, bismuth also causes many side efects. The aim of this study was to assess the effectiveness of quadruple therapies on H. pylori infection at Gia Dinh people’s hospita

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Shahbazi, Shaahin, Zahra Vahdat Shariatpanahi, and Nourkhoda Sadeghifard. "Effect of Proton Pump Inhibitor Based Triple Therapy with Apple Cider Vinegar on Helicobacter Pylori Eradication." Galen Medical Journal 3, no. 2 (2014): 90–94. http://dx.doi.org/10.31661/gmj.v3i2.97.

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Background: The purpose of this study was to evaluate the effect of apple cider vinegar plus PPI-based triple therapy on eradication of Helicobacter Pylori (H.pylori) infection.Materials and Methods: 116 patients with H. pylori infection were included in this randomized clinical trial. Patients in control group (n=59) received amoxicillin, clarithromycin, and pantaprazole twice daily. Patients in study group (57 patients) received the same regimen plus 30 mL of apple cider vinegar twice daily. The duration of therapy for study and control were 10 and 14 days respectively. Four weeks after the

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Jeong, Su Jin, Kyoung Hwa Lee, Jie-Hyun Kim, Soon Young Park, and Young Goo Song. "Efficacy and Gut Dysbiosis of Gentamicin-Intercalated Smectite as a New Therapeutic Agent against Helicobacter pylori in a Mouse Model." Antibiotics 9, no. 8 (2020): 502. http://dx.doi.org/10.3390/antibiotics9080502.

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Helicobacter pylori eradication rate with conventional standard therapy is decreasing owing to antibiotic resistance, necessitating novel antibacterial strategies against H. pylori. We evaluated the efficacy of a gentamicin-intercalated smectite hybrid (S-GM)-based treatment and analyzed fecal microbiome composition in H. pylori-infected mice. To evaluate anti-H. pylori efficacy, mice were divided into eight groups, and H. pylori eradication was assessed by a Campylobacter-like organism (CLO) test and PCR assay of H. pylori in gastric mucosa. One week after H. pylori eradication, pro-inflammat

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Lee, Tae Ho, Hang Yeon Jeong, Do Yeon An, et al. "Bamboo Salt and Triple Therapy Synergistically Inhibit Helicobacter pylori-Induced Gastritis In Vivo: A Preliminary Study." International Journal of Molecular Sciences 23, no. 22 (2022): 13997. http://dx.doi.org/10.3390/ijms232213997.

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Helicobacter pylori infections are a major cause of gastrointestinal disorders, including gastric ulcers, gastritis, and gastric cancer. Triple therapy, using two antibiotics and a proton pump inhibitor, is recommended for the treatment of H. pylori infections. However, antibiotic resistance in H. pylori is an emerging issue. Bamboo salt, a traditional Korean salt made by baking solar sea salt in bamboo barrels, can ameliorate the symptoms of various gastrointestinal diseases. Herein, we compared the anti-H. pylori activity of triple therapy (clarithromycin, metronidazole, and omeprazole), sol

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Liang, Chia-Ming, Chih-Hsiung Hsu, Chi-Hsiang Chung, et al. "Risk for Irritable Bowel Syndrome in Patients with Helicobacter Pylori Infection: A Nationwide Population-Based Study Cohort Study in Taiwan." International Journal of Environmental Research and Public Health 17, no. 10 (2020): 3737. http://dx.doi.org/10.3390/ijerph17103737.

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Background: The association between Helicobacter pylori (H. pylori) infection and the risk of developing irritable bowel syndrome (IBS) has yet to be investigated; thus, we conducted this nationwide cohort study to examine the association in patients from Taiwan. Methods: A total of approximately 2669 individuals with newly diagnosed H. pylori infection and 10,676 age- and sex-matched patients without a diagnosis of H. pylori infection from 2000 to 2013 were identified from Taiwan’s National Health Insurance Research Database. The Kaplan–Meier method was used to determine the cumulative incide

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Chen, Shasha, Weina Shen, Yuhuan Liu, Qiang Dong, and Yongquan Shi. "Efficacy and safety of triple therapy containing berberine, amoxicillin, and vonoprazan for Helicobacter pylori initial treatment: A randomized controlled trial." Chinese Medical Journal 136, no. 14 (2023): 1690–98. http://dx.doi.org/10.1097/cm9.0000000000002696.

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Abstract Background: With the development of traditional Chinese medicine research, berberine has shown good efficacy and safety in the eradication of Helicobacter pylori (H. pylori). The present study aimed to evaluate the efficacy and safety of triple therapy containing berberine, amoxicillin, and vonoprazan for the initial treatment of H. pylori. Methods: This study was a single-center, open-label, parallel, randomized controlled clinical trial. Patients with H. pylori infection were randomly (1:1:1) assigned to receive berberine triple therapy (berberine 500 mg, amoxicillin 1000 mg, vonopr

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Aryani, Fransisca Theresia, Agus Firmansyah, and Abdul Latief. "Comparison of combination of probiotic and standard therapy compared to standard therapy on eradication of Helicobacter pylori infection in children." Paediatrica Indonesiana 50, no. 1 (2016): 38. http://dx.doi.org/10.14238/pi50.1.2010.38-41.

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Background Helicobacter pylori (H. pylori) infection is thought to be the etiology of chronic gastritis, peptic ulcer, and risk factor for gastric cancer. Management of H. pylori infection in children is associated with several problems such as compliance to therapy, untolerated side effects, and antibiotic resistance. Probiotic is reported to give beneficial effect in the management of H. pylori infection and there is no study yet on the effect of probiotic in eradication of H. pylori infection in Indonesian children.Objectives To study the effect of additional probiotic in the standard thera

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Zarić, S., B. Bojić, Lj Janković, et al. "Periodontal Therapy Improves Gastric Helicobacter pylori Eradication." Journal of Dental Research 88, no. 10 (2009): 946–50. http://dx.doi.org/10.1177/0022034509344559.

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The oral cavity has been proposed as a reservoir for H. pylori that could be responsible for the refractoriness of gastric infection to triple therapy (antibiotics, antimicrobials, and proton pump inhibitors). The aim of this study was to evaluate the efficiency of combined periodontal and triple therapy vs. triple therapy alone, in gastric H. pylori eradication in persons with H. pylori in the subgingival biofilm. Individuals positive for H. pylori in their gastric and oral samples, as determined by nested PCR, were treated either with periodontal and triple therapy or with triple therapy alo

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Uspenskiy, Yu P., and N. V. Baryshnikova. "Functional dyspepsia and dyspepsia associated with Helicobacter pylori infection." Voprosy dietologii 11, no. 1 (2021): 50–56. http://dx.doi.org/10.20953/2224-5448-2021-1-50-56.

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The article presents algorithms for diagnosing and treatment of patients with H. pylori associated dyspepsia and functional dyspepsia. The importance of testing all patients with dyspepsia for H. pylori infection is emphasized, since H. pylori status has an impact on both therapy and prognosis of disease. Dyspepsia in H. pylori-positive patients is regarded as secondary, associated with H. pylori, and this cohort of patients undergoes anti-Helicopacter therapy. Dyspepsia in H. pylori-negative patients is regarded as functional dyspepsia, if there are relevant diagnostic criteria, and this coho

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Arnold, Donald M., Ashley Bernotas, Ishac Nazi, et al. "The Efficacy of H. pylori Eradication Therapy in H. pylori-Infected and Uninfected Patients with Immune Thrombocytopenic Purpura: A Systematic Review." Blood 112, no. 11 (2008): 3413. http://dx.doi.org/10.1182/blood.v112.11.3413.3413.

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Abstract Introduction: Helicobacter pylori eradication therapy results in the improvement of thrombocytopenia in up to 60% of patients with chronic immune thrombocytopenic purpura (ITP). Whether this effect is directly linked to H. pylori eradication, or to other effects of the treatment such as immune modulation or the eradication of other commensal bacteria, remains uncertain. We performed a systematic review of the literature to determine the independent effect of H. pylori eradication therapy on the platelet count in ITP by comparing its efficacy in H. pylori-infected and uninfected patien

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Choi, Youn I., and Jun-Won Chung. "Helicobacter pylori Eradication in Patients Undergoing Gastrectomy: Diagnosis and Therapy." Korean Journal of Helicobacter and Upper Gastrointestinal Research 20, no. 3 (2020): 204–9. http://dx.doi.org/10.7704/kjhugr.2019.0037.

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The role of <i>Helicobacter pylori</i> (<i>H. pylori</i>) eradication in patients undergoing gastrectomy for gastric cancer is unclear. Although European and Asian guidelines strongly recommend <i>H. pylori</i> eradication in patients who undergo endoscopic resection for early gastric cancer, these guidelines do not specify the tests useful for diagnosing <i>H. pylori</i> infection, the optimal timing and appropriate eradication regimens, and follow-up strategies in patients undergoing gastrectomy for gastric cancer. This review aims to update th

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Park, Chan Hyuk. "Changes in Gastric Microbial Composition before and after Helicobacter pylori Eradication Therapy." Korean Journal of Helicobacter and Upper Gastrointestinal Research 20, no. 3 (2020): 177–86. http://dx.doi.org/10.7704/kjhugr.2020.0028.

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Owing to advancements in next-generation sequencing and non-culture-based microbial research techniques, we have recognized that many bacterial taxa other than <i>Helicobacter pylori (H. pylori)</i> are present in the human stomach. Gastric microbial composition depends on gastric diseases, including gastritis, atrophic gastritis, intestinal metaplasia, and gastric cancer. Although <i>H. pylori</i> is a major factor associated with gastric cancer development, other bacterial taxa may affect gastric carcinogenesis. Because the risk of gastric cancer development can be re

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Nguyen, Liem Thanh, Vuong Ba Nguyen, Tu Viet Tran, et al. "Efficacy of Helicobacter pylori Eradication Based on Rabeprazole–Bismuth–Tetracycline–Tinidazole Regimen in Vietnamese Patients with Duodenal Ulcers." Gastroenterology Insights 13, no. 4 (2022): 365–76. http://dx.doi.org/10.3390/gastroent13040036.

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(1) Background: In Vietnam, H. pylori bacteria has a resistance rate of 63% to the antibiotic clarithromycin. The initial therapy of H. pylori eradication with a standard three-drug regimen has low efficacy. Objective: Assess the efficacy of H. pylori eradication therapy which uses a four-drug regimen of rabeprazole–bismuth–tetracycline–tinidazole in patients with duodenal ulcers. (2) Methods: We performed gastrointestinal endoscopy on patients with a diagnosis of duodenal ulcers, gastric mucosa biopsy for a rapid urease test, and histopathology to diagnose H. pylori bacteria before and after

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Schanova, Natalya O., and Lyudmila V. Prokhorova. "Improvement of Helicobacter pylori eradication efficacy at stomach and duodenum peptic ulcers." Russian Journal of Gastroenterology, Hepatology, Coloproctology 26, no. 2 (2016): 11–18. http://dx.doi.org/10.22416/1382-4376-2016-26-2-11-18.

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Aim of investigation. To estimate efficacy of the modified sequential therapy regimen of Helicobacter pylori (H. pylori) eradication (with addition of bismuth tripotassium dicitrate) at treatment of peptic ulcer of the stomach (PUS) and duodenum (PUD) of severe and complicated course in the Russian population. Material and methods. Original study included overall 105 patients with PUS and PUD with severe and complicated course of disease. The main group received modified sequential therapy regimen, the comparison group - standard triple mode. All patients underwent quantitative serological tes

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Liou, Jyh-Ming, Yi-Chia Lee, Emad M. El-Omar, and Ming-Shiang Wu. "Efficacy and Long-Term Safety of H. pylori Eradication for Gastric Cancer Prevention." Cancers 11, no. 5 (2019): 593. http://dx.doi.org/10.3390/cancers11050593.

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Helicobacter pylori (H. pylori) has been shown to be a causal factor of gastric cancer in cohort studies and animal models. Meta-analysis of case-control studies nested within prospective cohorts showed that H. pylori infection was associated with a 5.9-fold increased risk of non-cardia gastric cancer. Prospective cohort studies showed that gastric cancer developed in 1–4% of H. pylori-infected subjects. Gastric cancer was successfully induced in Mongolian gerbils and insulin-gastrin (INS-GAS) transgenic mice after inoculation of H. pylori. Meta-analysis of randomized control trials also showe

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Dekhnich, Natalya N., Nataly V. Ivanchik, Roman S. Kozlov, A. V. Alimov, A. S. Steshits, and P. P. Kirsov. "Antimicrobial resistance of Helicobacter pylori in Smolensk." Clinical Microbiology and Antimicrobial Chemotherapy 20, no. 1 (2018): 42–48. http://dx.doi.org/10.36488/cmac.2018.1.42-48.

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Objective. To study the antimicrobial resistance of H. pylori to clarithromycin, amoxicillin, metronidazole, levofloxacin, tetracycline in adult patients in the Smolensk region. Materials and Methods. Overall, 573 adult patients were included in 2015-2017 and 210 – in 20092010 with positive rapid urease test at the time of gastroscopy for dyspeptic complaints. Antimicrobial susceptibility testing of H. pylori isolates to clarithromycin, amoxicillin, metronidazole, levofloxacin and tetracycline was performed by the agar dilution method. Results. 143 and 133 strains of H. pylori isolated in 2015

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Ahmad, Hazhan Nawzad, Makwan Mohammed Abdulkareem, and Muhamad Abdularahman Muhamad Alshekhani. "THE FACTORS RELATED TO H. PYLORI INFECTION RESISTANCE AFTER ERADICATION OR ITS RECURRENCE IN SULAIMANI CITY." PHARMACOLOGY MEDICAL REPORTS ORTHOPEDIC AND ILLNESS DETAILS (COMORBID) 3, no. 3 (2024): 109–21. https://doi.org/10.55047/comorbid.v3i3.1414.

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Helicobacter pylori (H. pylori) infection can lead to peptic ulcers, chronic gastritis, lymphoma and gastric cancer. This study aimed to assess the factors related to H. pylori resistance after eradication and its recurrence after 6 months. 574 patients tested for H. pylori and those who positive has been assessed for recurrence after 6 months or resistance to treatment and factors related to recurrence in correlation with demographic data. 51% of men and 49% of women were still testing positive for H. pylori after receiving treatment. The majority of patients who tested positive again for H.

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Ikuse, Tamaki, Masanori Toda, Kosuke Kashiwagi, et al. "Efficacy of Helicobacter pylori Eradication Therapy on Platelet Recovery in Pediatric Immune Thrombocytopenic Purpura-Case Series and a Systematic Review." Microorganisms 8, no. 10 (2020): 1457. http://dx.doi.org/10.3390/microorganisms8101457.

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Evidence relating to the efficacy of Helicobacter pylori eradication therapy for chronic immune thrombocytopenic purpura (cITP) in childhood is inadequate. The aim of this retrospective study was to determine the efficacy of H. pylori eradication therapy for platelet response in pediatric patients with cITP in our hospital, and to perform a systematic review of previous reports about pediatric patients with cITP who were positive for H. pylori infection and were treated with H. pylori eradication therapy. Analysis of the data of pediatric patients with cITP in our hospital and a systematic rev

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Ivashkin, V. T., T. L. Lapina, I. V. Maev, et al. "Clinical Practice Guidelines of Russian Gastroenterological Association, Scientific Society for the Clinical Study of Human Microbiome, Russian Society for the Prevention of Non-Communicable Diseases, Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy for <i>H. pylori</i> Diagnostics and Treatment in Adults." Russian Journal of Gastroenterology, Hepatology, Coloproctology 32, no. 6 (2022): 72–93. http://dx.doi.org/10.22416/1382-4376-2022-32-6-72-93.

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Aim: bring to the attention of practitioners indications for anti-Helicobacter therapy, methods and procedure for diagnostics and eradication therapy of Н. pylori infection.Key points. Chronic gastritis caused by Н. pylori infection, including asymptomatic persons, may be considered as an indication for eradication therapy of Н. pylori as etiological therapy and opportunistic screening for gastric cancer prevention. Indications, for obligatory anti-Helicobacter therapy include peptic ulcer, gastric MALT lymphoma, early gastric cancer (EGC) with endoscopic resection. H. pylori primary diagnosti

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Kanu, Joseph Edwin, and Jonathan Soldera. "Treatment of Helicobacter pylori with potassium competitive acid blockers: A systematic review and meta-analysis." World Journal of Gastroenterology 30, no. 9 (2024): 1213–23. http://dx.doi.org/10.3748/wjg.v30.i9.1213.

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BACKGROUND Helicobacter pylori (H. pylori ) infects over half the global population, causing gastrointestinal diseases like dyspepsia, gastritis, duodenitis, peptic ulcers, G-MALT lymphoma, and gastric adenocarcinoma. Eradicating H. pylori is crucial for treating and preventing these conditions. While conventional proton pump inhibitor (PPI)-based triple therapy is effective, there’s growing interest in longer acid suppression therapies. Potassium competitive acid blocker (P-CAB) triple and dual therapy are new regimens for H. pylori eradication. Initially used in Asian populations, vonoprazan

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Amitesh, Kumar, and Agrawal Rawi. "Impact of Eradicating Helicobacter Pylori on the Occurrence of Noncardia Gastric Adenocarcinoma in a Broad, Diverse Population." International Journal of Pharmaceutical and Clinical Research 15, no. 12 (2023): 1735–37. https://doi.org/10.5281/zenodo.11206866.

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<strong>Background:</strong> Helicobacter pylori (H. pylori) is a chief risk reason for gastric cancer, particularly noncardia gastric adenocarcinoma (NCGA). This study investigates the impact of H. pylori eradication on the frequency of NCGA, considering the global frequency of H. pylori infection and the significant burden of gastric cancer. <strong>Methods:</strong> A retrospective cohort study was conducted on 80 individuals who underwent H. pylori testing and were categorized based on their test results and exposure to eradication therapy. Data on H. pylori testing methods

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Sheptulin, A. A., S. S. Kardasheva та A. A. Kurbatova. "Modern approaches to the choice of schemes for eradication of Helicobacter рylori infection (based on the materials of the consensus meeting "Maastricht-VI")". Clinical Medicine (Russian Journal) 101, № 11 (2023): 582–87. http://dx.doi.org/10.30629/0023-2149-2023-101-11-582-587.

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The article presents an analysis of the provisions of the consensus meeting “Maastricht-VI”, dedicated to the treatment of Helicobacter pylori (H. pylori) infection. The expediency of preliminary testing for H. pylori sensitivity to antibiotics is emphasized. Since this strategy has not yet been implemented in everyday clinical practice, empirical therapy is often carried out based on the results of the assessment of H. pylori resistance to antibiotics in this region. The sequence of administration of eradication regimens of the 1st, 2nd, 3rd, 4th lines, optimal duration of treatment, new ther

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Simanenkov, Vladimir I., and Sergei A. Alekseenko. "Prospects for personalized Helicobacter pylori eradication therapy. Pro et contra." Terapevticheskii arkhiv 94, no. 8 (2022): 935–39. http://dx.doi.org/10.26442/00403660.2022.08.201787.

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The article is devoted to debatable aspects of Helicobacter pylori eradication therapy. The eradication cancer-preventive effects are considered. A negative comorbidity between H. pylori infection and such diseases as gastroesophageal reflux disease, inflammatory bowel disease and bronchial asthma has been described. The perspectives of populational, individualized and personalized strategies for H. pylori eradication therapy assessment are given. Recommendations for individualized H. pylori eradication strategy implementation in practical healthcare are proposed.

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Roszczenko-Jasińska, Paula, Marta Ilona Wojtyś, and Elżbieta K. Jagusztyn-Krynicka. "Helicobacter pylori treatment in the post-antibiotics era—searching for new drug targets." Applied Microbiology and Biotechnology 104, no. 23 (2020): 9891–905. http://dx.doi.org/10.1007/s00253-020-10945-w.

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Abstract Helicobacter pylori, a member of Epsilonproteobacteria, is a Gram-negative microaerophilic bacterium that colonizes gastric mucosa of about 50% of the human population. Although most infections caused by H. pylori are asymptomatic, the microorganism is strongly associated with serious diseases of the upper gastrointestinal tract such as chronic gastritis, peptic ulcer, duodenal ulcer, and gastric cancer, and it is classified as a group I carcinogen. The prevalence of H. pylori infections varies worldwide. The H. pylori genotype, host gene polymorphisms, and environmental factors deter

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Yang, Lili, Ao Zou, Huihua Wu, et al. "Application of Visual Gene Clip-Based Tailored Therapy for the Eradication of Helicobacter pylori." BioMed Research International 2021 (April 10, 2021): 1–6. http://dx.doi.org/10.1155/2021/6150628.

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Background. Helicobacter pylori eradication with therapies employing a proton pump inhibitor (PPI) and antimicrobial agents is mainly achieved via bacterial susceptibility to antimicrobial agents and the magnitude of acid secretion inhibition. However, annual eradication rates have greatly declined in Mainland China, and therefore, tailored H. pylori eradication regimens that inhibit acid secretion and employ optimal antimicrobial agents determined based on gene clip testing may improve eradication rates. This study was aimed at evaluating the efficacy of tailored H. pylori eradication therapy

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Isaeva, Guzel Sh, and R. A. Isaeva. "Mechanisms of microbial interactions between probiotic microorganisms and Helicobacter pylori." Clinical Microbiology and Antimicrobial Chemotherapy 25, no. 3 (2023): 225–38. http://dx.doi.org/10.36488/cmac.2023.3.225-238.

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Infection caused by Helicobacter pylori is currently one of the most common infection in the world, but the clinical picture can vary from asymptomatic manifestations to the development of stomach cancer. In order to eradicate the pathogen various regimens of antibacterial therapy have been proposed, but recent studies indicate a decrease in efficiency of this therapy due to the increasing rate of H. pylori resistance to antibiotics, the appearance of side effects, including the development of dysbiosis. One of the perspective directions of an alternative approach to the treatment of helicobac

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Нургалиева, Б. К. "ЭРАДИКАЦИОННАЯ ТЕРАПИЯ HELICOBACTER PYLORI". Наука и здравоохранение, № 1(27) (28 лютого 2025): 257–66. https://doi.org/10.34689/sh.2025.27.1.028.

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Актуальность. Helicobacter pylori – бактерия, вызывающая хронический активный гастрит, пептическую язвенную болезнь, желудочную аденокарциному, МАЛТ-лимфому, атрофический гастрит. В последние годы в мире развилась устойчивость Helicobacter pylori к различным антибиотикам, что требует изучения вопроса и разработки новых схем терапии.) Цель: анализ современных подходов к эрадикационной терапии Helicobacter pylori по данным современной литературы. Стратегия поиска. Поиск научной литературы проводился в базах данных PubMed, Scopus, Web of Science и Cochrane Library за период с 2014 по 2024 год. Ис

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Perkins, S. E., L. L. Yan, Z. Shen, A. Hayward, J. C. Murphy, and J. G. Fox. "Use of PCR and culture to detect Helicobacter pylori in naturally infected cats following triple antimicrobial therapy." Antimicrobial Agents and Chemotherapy 40, no. 6 (1996): 1486–90. http://dx.doi.org/10.1128/aac.40.6.1486.

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Helicobacter pylori causes gastritis and peptic ulcers and is linked to gastric cancer. Domestic cats from a commercial source were found to be naturally infected with H. pylori, and studies were undertaken to eradicate H. pylori from infected cats by using triple antimicrobial therapy. Eight cats infected with H. pylori were used in the study. Six cats received a 21-day course of oral amoxicillin, metronidazole, and omeprazole, and two cats served as controls. Two weeks and 4 weeks posttreatment (p.t.), all six treated cats were negative at several sites (saliva, gastric juice, and gastric mu

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Sayadishahraki, Masoud, Mahsa Khodadoostan, Hossein Bahrami Samani, Flora Mazaheri, and Somayeh Haghighat. "Body Mass Index and the Success of Helicobacter-pylori Eradication Therapy." Annals of Bariatric Surgery 10, no. 1 (2021): 21–26. http://dx.doi.org/10.32598/abs.10.1.1.

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Objective: Helicobacter pylorus (H. pylori) is a gram-negative spiral bacterium related to varieties of gastric and extra-gastric complications. The effects of H. pylori infection on cardiometabolic conditions such as dyslipidemia, diabetes, and metabolic syndrome have to need to be investigated. The present paper aims to assess the effects of body mass index on the success of helicobacter-pylori eradication therapy for the first time. Patients and Methods: This study included 198 patients with H. pylori infection. Patients underwent H. pylori eradication using clarithromycin (500 mg, twice da

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