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Dissertations / Theses on the topic 'Haematologica'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Li, Jinlei. "Estimating prevalence of haematological malignancies using data from the Haematological Malignancy Research Network (HMRN)." Thesis, University of York, 2014. http://etheses.whiterose.ac.uk/6179/.

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The prevalence of the haematological malignancies enumerates those currently living with past diagnosis of this class of diseases, and provides insights regarding survivor populations and their burden. However, there is a lack of accurate information regarding the prevalence of the haematological malignancies. This is partly because of changing disease classifications and the fact that the current methods available to estimate total prevalence have not always been appropriate due to the characteristics of the disease including age at diagnosis and the introduction of novel treatments that have

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2

Erber, W. N. "Immunocytochemical studies of haematological disorders." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355747.

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3

Parker, Helen. "Genetic profiling of haematological malignancies." Thesis, University of Southampton, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494706.

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The different classes of leukaemia comprise numerous heterogeneous subgroups, which differ in their cellular and molecular characteristics. Accurate risk stratification is essential for tailoring of therapy. Based upon clinical features and cytogenetic and molecular diagnostics, the majority of ALL patients are assigned to one of the following prognostically significant subtypes having; ETV6-RUNX1, BCR-ABL1 or TCF3-PBX1 fusions, MLL rearrangements, high hyperdiploidy (HeH) with >50 chromosomes, hypodiploidy or T-ALL. Whilst these genetic abnormalities are important in leukaemogenesis, and prov

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4

Ahmadizad, Sajad. "Haematological responses to resistance exercise." Thesis, Liverpool John Moores University, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521758.

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5

Assaf, Areej Mashhour Tawfiq. "Human toll-like receptor 9 (hTLR9) expression and function in haematological and non-haematological malignancies." Thesis, University of Leicester, 2008. http://hdl.handle.net/2381/30498.

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This thesis addresses the expression and function of human TLR9 in haematological and non-haematological tumour cells. I have shown that most B linage tumour cell lines expressed TLR9, with the exception of myeloma cell lines U266, Karpas 707H and the EBV-lymphoblastoid HMy2 cell line, whereas all non-haematological cell lines tested were negative or very weakly positive. TLR9 positive B-cells/B-cell lines, responded to CpG-ODN activation by activating intracellular signalling pathways, cytokine release, surface marker upregulation and cellular proliferation, whereas TLR9 negative cells did no

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6

Jahanmehr, S. A. H. "An evaluation of the role of circulating blood reticulocytes in the assessment of haematological status." Thesis, University of Manchester, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234232.

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7

Smyth, David William. "The haematological determinants of angioplasty restenosis." Thesis, Queen Mary, University of London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244764.

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8

Hanlon, Katy Louise. "The molecular analysis of haematological malignancies." Thesis, Exeter and Plymouth Peninsula Medical School, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.516997.

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9

Reilly, J. T. "Fibronectin and laminin : A haematological study." Thesis, University of Liverpool, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372702.

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10

Mussai, Francis Jay. "Immunotherapy and immunomodulation for haematological malignancies." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:6120e659-0dab-4447-b4d6-75e235d3b2c8.

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HA22 is an immunotoxin composed of an anti-CD22 variable fragment linked to a 38 kDa truncated protein derived from Pseudomonas exotoxin A. The mechanisms of cytotoxicity and resistance of HA22 against Acute Lymphoblastic Leukaemia (ALL) and Burkitt’s lymphoma were studied. Using a bone marrow mesenchymal cell culture assay to support ALL cell viability, I? investigated the in vitro cytotoxicity of HA22 against ALL blasts from newly diagnosed and relapsed patients. There was interpatient variability in sensitivity to HA22. There was no significant difference in HA22 sensitivity between diagnos

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11

Koivunen, Elli. "Hematologiset löydökset sarkoidoosissa Haematological findings in sarcoidosis /." Tampere : Tampereen yliopisto, 1985. http://catalog.hathitrust.org/api/volumes/oclc/57781487.html.

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12

Marks, Alexandra Jane. "Targeting of cytotoxic peptides to haematological malignancies." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1444842/.

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Amphipathic peptides with an a-helical structure disrupt membranes rich in negatively charged phospholipids and have antibiotic properties. They are toxic to eukaryotic cells if internalised by a suitable targeting mechanism. We have targeted one such peptide D(KLAKLAK)2 to haemopoetic cells by conjugating it to monoclonal antibodies which recognise lineage-specific cell-surface molecules. An anti-CD33: peptide conjugate was cytotoxic to one of three CD33-positive myeloid leukaemia lines, whereas an anti- CD 19: peptide conjugate efficiently killed three out of three B lymphoid lines with IC50

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13

鄺沃林 and Yok-lam Kwong. "Cytogenetics and molecular genetics of haematological disorders." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1995. http://hub.hku.hk/bib/B31981550.

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14

Bradshaw, Paul Stuart. "The ataxia telanglectasi gene in haematological malignancies." Thesis, Institute of Cancer Research (University Of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251961.

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15

Challoner, Teresa. "Serial venesection : clinical, haemorheological and haematological sequelae." Thesis, University of Aberdeen, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327829.

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Haematocrit in the high normal, as well as the pathological, range may be a risk factor for the development of stroke. As stroke is one of the most important causes of physical handicap attempts to reduce its incidence further are justified. Repeated small volume venesection without volume replacement is a simple method of haematocrit reduction which could be used in a controlled trial if shown to be safe and practicable. Forty three male patients (33 evaluable) with haematocrit above 0.46 without primary proliferative or secondary polycythaemia, were entered into an open study to assess the c

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16

Rhodes, Susan. "Investigation of JAK2 targets in haematological malignancy." Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/8387/.

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Janus kinase 2 (JAK2) is a critical activator of signalling associated with many different receptors, particularly those associated with haematopoiesis and the inflammatory response. Classically JAK2 has been thought of as a cytoplasmic protein, but more recently there is evidence that JAK2 is able to enter the nucleus leading to alteration of epigenetic modifiers and enhancement of JAK2 transcriptional targets. This role in haematopoiesis means that alteration of JAK2 signalling, such as in malignant haematopoiesis, can be a critical factor in the development and maintenance of disease. The m

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17

Saeed, L. S. A. M. "Genetic determinants of sepsis in haematological malignancy." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1333965/.

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Background: Sepsis is a systemic illness caused by microbial invasion of normally sterile parts of the body. In haematological malignancies, patients are more prone to developing infections due to defects in the neutrophil count and function which occur as a part of the neoplastic process or due to chemotherapy. The presence of neutropenia calls for other means of defence including the innate immune system. Genetic studies have attempted to examine the relationship between particular genes involved in innate immunity and susceptibility to infections. Genes involved in the host defence mechanis

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18

Craig, Jenny I. O. "Peripheral blood stem cells in haematological malignancies." Thesis, University of Edinburgh, 1991. http://hdl.handle.net/1842/19651.

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Autologous bone marrow transplantation is used successfully as intensive therapy for patients with haematological malignancies and other solid tumours. Peripheral blood contains haematopoietic progenitors whose levels are greatly increased during very early remission after treatment for acute leukaemia or after high dose chemotherapy schedules. These circulating progenitors have been harvested by leucapheresis and used as an alternative to bone marrow as salvage after myeloablative treatments. Peripheral blood stem cells (PBSC) appear to have several advantages over bone marrow including rapid

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19

Kwong, Yok-lam. "Cytogenetics and molecular genetics of haematological disorders." Hong Kong : University of Hong Kong, 1995. http://sunzi.lib.hku.hk/hkuto/record.jsp?B14036423.

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20

Bianco-Miotto, Tina. "Loss of ABO antigens in haematological malignancies." Adelaide, S.A, 2002. http://web4.library.adelaide.edu.au/theses/09PH/09phb578.pdf.

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"May 2002" Includes bibliographical references (leaves 229-251) Describes the investigation of the alteration of ABH antigen expression on the surface of red blood cells in patients with haematological malignancies.

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21

Gallager, Katherine S. "Factors influencing resilience among haematological cancer survivors." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2016. https://ro.ecu.edu.au/theses/1777.

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Haematological cancers in bone marrow (leukaemia) and the immune system (lymphomas or myeloma) represent the sixth most common adult tumour group in Australia. These cancers often develop without warning and require intensive treatment regimes that last on average eight months, but may continue for a lifetime depending on the diagnosis. Encouragingly, advancing cancer treatments, a key accomplishment of cancer research over the past 40 years, have resulted in a growing community of cancer survivors. Approximately two in three adults diagnosed with haematological cancer (HC) can now expect to s

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22

Martínez-Martín, Sandra. "Targeting MYC in B-cell haematologic malignancies." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/670653.

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La importància de la funció de MYC en el càncer (i l’origen del nom de la oncoproteïna) es va descobrir a finals dels 70, amb la identificació de la seqüència del retrovirus aviar causant de la leucèmia mielocítica. Durant més de 40 anys d’investigació, s’ha subratllat la rellevància d’aquesta proteïna en la divisió cel·lular normal i la seva implicació en la transformació tumoral. De fet, una de les primeres connexions entre la sobreexpressió de proto-oncògens (com MYC), reordenaments gènics i el càncer es va fer en el limfoma de Burkitt, la leucèmia mieloide crònica i els plasmacitomes de r

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23

Milne, Paul. "Dendritic cell development in haematological malignancies and neoplasia." Thesis, University of Newcastle upon Tyne, 2015. http://hdl.handle.net/10443/3015.

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Dendritic cells (DC) play a major role in the detection of antigens, initiation of immunity and induction and regulation of tolerance. DCs are Bone Marrow (BM) derived and their development may be influenced by haematological malignancy in several ways. Firstly, myelodysplastic, myeloproliferative or leukaemic transformation of bone marrow progenitors may involve DC precursors directly, when they become part of a malignant clone, or indirectly when neoplastic expansion of other lineages compromises the development of DCs. Secondly, neoplasia of the dendritic cell lineage itself may occur in a

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24

Grand, Effie Kyriacou. "Deregulated fibroblast growth factor receptors in haematological malignancies." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419978.

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25

Dempsey, Nina Claire. "Localisation of heat shock proteins in haematological malignancies." Thesis, University of Chester, 2009. http://hdl.handle.net/10034/93233.

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Although a number of HSPs have been shown to be up-regulated in a wide range of human cancers, the full significance of this remains to be determined. The localisation of HSPs seems to be critical in determining their role in cancer cell survival; High intracellular levels (iHsp) appear to be advantageous to the tumour cell, inhibiting key steps in apoptosis, while in some circumstances, surface expression (sHsp) appears to be detrimental to the cell, aiding immune recognition by various effector cells. Consequently, clarifying the importance of HSP cellular location in the cancer setting may

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26

Bullock, Tabitha Emily. "Investigation of the dynamics of 'haematological synapse' formation." Thesis, Imperial College London, 2007. http://hdl.handle.net/10044/1/11944.

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27

Högberg, Karin. "Web-based counselling to patients with haematological diseases." Doctoral thesis, Hälsohögskolan, Högskolan i Jönköping, HHJ. ADULT, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-26454.

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Patients with haematological diseases are entitled to supportive care. Considering organisational and technological development, support in the form of caring communication provided through the web is today a possible alternative. The aim of this thesis was to examine the usefulness and importance of a web-based counselling service to patients with haematological diseases. The basis for the thesis was a development project funded by the Swedish Cancer Society, which provided an opportunity to offer patients communication with a nurse through a web-based counselling service. Four studies were p

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28

Watkins, Jane Katharyn. "Inducing immunity to haematological malignancies with DNA vaccines." Thesis, University of Southampton, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418048.

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29

Benjamin, R. "Antiangiogenic strategies for the treatment of haematological malignancies." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1347244/.

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Angiogenesis plays a key role in the pathogenesis of haematological malignancies such as acute myeloid leukaemia (AML), multiple myeloma (MM) and lymphoma (NHL). The evidence supporting this theory includes the finding of increased bone marrow microvessel density and increased levels of plasma and urinary pro-angiogenic cytokines in patients with these malignancies as well as encouraging results from preclinical and clinical studies using antiangiogenic therapies. A significant limiting factor in most of these studies has been the short half-life of most antiangiogenic compounds which has nece

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30

Haigh, Teresa. "Dielectrophoretic investigations of haematological cells : procedures and applications." Thesis, University of York, 1995. http://etheses.whiterose.ac.uk/10833/.

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31

Screen, Michael P. "MicroRNA control of drug-resistance in haematological malignancies." Thesis, University of Leicester, 2015. http://hdl.handle.net/2381/32535.

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miRNAs have been shown to play a role in fundamental cellular processes. They are also involved in drug-resistance mechanisms, which hamper the treatment of many types of cancer, including haematological malignancies. This study sought to uncover mechanisms of miRNA-induced drug-resistance in two haematological malignancies: diffuse large B-cell lymphoma (DLBCL) and multiple myeloma (MM). To this end, profiling of DLBCL and MM-derived cell lines was carried out to identify miRNAs whose levels were altered relative to their respective controls. The expression levels of these miRNAs were then mo

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32

Pan, Beiqing. "Mechanisms of skeletal disease mediated by haematological malignancies /." Title page, table of contents and abstract only, 2004. http://web4.library.adelaide.edu.au/theses/09PH/09php1871.pdf.

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Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine and The Hanson Centre, Institute of Medical and Veterinary Science, 2004.<br>"August 2004" Errata inside front cover. Bibliography: leaves 126-159.

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33

Wang, Sicong. "Investigating cellular responses after inhibition of the thioredoxin system in lymphoma." Thesis, Griffith University, 2022. http://hdl.handle.net/10072/417233.

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Lymphoma is a haematological cancer that develops in the lymphatic system. Hodgkin’s lymphoma (HL) and non-Hodgkin’s lymphoma (NHL) are the two main lymphoma subtypes. HL is commonly diagnosed in young people and in adults over the age of 55. NHL is a more aggressive subtype than HL, and it accounts for approximately 90% of all lymphoma cases. Despite the development of different chemotherapy regimens for lymphoma treatment, 40-50% of lymphoma patients fail to achieve long-term survival rates because some patients do not respond to chemotherapy or they become resistant to the treatment. Additi

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34

Harbourne, Tikva. "Biochemical and haematological changes in patients with venous problems." Thesis, Imperial College London, 1991. http://hdl.handle.net/10044/1/46803.

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35

Scheepers, Elrien. "The haematological kinetics of canine babesiosis in South Africa." Diss., Electronic thesis, 2008. http://upetd.up.ac.za/thesis/available/etd-07162008-132522/.

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36

Jaju, Rina Jagdish. "Molecular cytogenic studies of chromosome 5 in haematological malignancies." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299047.

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37

Campbell, Andrew J. "The role of FOXP4 and FOXP2 in haematological malignancy." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.510935.

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38

Estcourt, Lise Jane. "Risk factors for haemorrhage in patients with haematological malignancies." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:4efbd9b1-62e5-4536-a5ee-df5eea4620d0.

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Haematological malignancies and their treatment lead to prolonged periods of severe thrombocytopenia (platelet count ≤ 50 x 10<sup>9</sup>/l). Despite the use of prophylactic platelet transfusions, haemorrhage remains an important complication during this thrombocytopenic period. Within a 30 day period up to 70% of patients have clinically significant haemorrhage (World Health Organization (WHO) grade 2 or above bleeding) and up to 10% have severe or life-threatening haemorrhage (WHO grade 3 or 4 bleeding). Hence our current management of these patients to prevent haemorrhage is sub-optimal. T

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39

Pourgheysari, Batoul. "Immunity to cytomegalovirus in immunosuppressed patients with haematological malignancies." Thesis, University of Birmingham, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403913.

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40

Obel, Owen A. "Thromboembolism in nonvalvular artrial fibrillation : haemodynamic and haematologic mechanisms." Thesis, St George's, University of London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.546790.

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41

Swash, Brooke. "The unmet psychosocial needs of haematological cancer patients and their impact upon psychological wellbeing." Thesis, University of Chester, 2015. http://hdl.handle.net/10034/600585.

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Unmet psychosocial needs indicate a desire for additional support in cancer patients, having a direct clinical utility in directing the provision of supportive care. There is evidence in wider cancer groups that unmet needs relate to psychological wellbeing but this relationship has yet to be fully explored and factors that may explain or moderate this relationship yet to be examined. There has been little investigation of type or prevalence of unmet need in haematological cancer patients, however, haematological cancers are noteworthy for their high levels of associated distress. Understandin

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42

Jones, Chris I. "Haematological and clinical factors influencing thrombus formation, structure and fibrinolysis." Thesis, University of Leicester, 2007. http://hdl.handle.net/2381/29893.

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This work investigates how changes in the thrombus over time, and in the action of platelets, brought about by physiological or therapeutic factors, influence the susceptibility of thrombi to fibrinolysis. Resistance to fibrinolysis increased with thrombus age, and was associated with expression and/or release of FXIII, TAFI, PAI-1, and FXI, by cells within the thrombus, the recruitment of which was largely platelet dependant. Platelets increase resistance to fibrinolysis through release of FXIII and TAFI, and act pro-fibrinolytically through the recruitment of monocytes, and, by a yet undeter

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43

Al-Qouzi, Abdullah Ahmed. "The clinical relevance of angiogenesis and lymphangiogenesis in haematological malignancies." Thesis, University of Manchester, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491158.

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Unlike solid tumours, the possible role of angiogenesis and lymphangiogenesis markers in human haematological malignancies has not been extensively examined. The first part of this study was undertaken to quantify a panel of angiogenic markers viz CDlO5, its two ligands TGF-Pl, TGF-p3, and receptor-ligand complexes (CDlO5/TGF-p1, CD105/TGF-P3) and a marker oflymphangiogenesis (VEGF-C) in plasma samples from 176 children with newly diagnosed leukaemia comprising common acute lymphoblastic leukaemia (cALL) (n=73), acute myeloid leukaemia (AML) (n=24), T cell acute lymphoblastic leukaemia (T cell

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44

Chan, Yuk-yin, and 陳玉燕. "Haematological and molecular studies of Thalassaemias in Hong Kong Chinese." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31215014.

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45

Bailey, Simon. "Molecular determinants of the response to glucocorticoids in haematological malignancies." Thesis, University of Newcastle Upon Tyne, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297676.

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46

Caldwell, Ellie M. "Experiences of living with incurable haematological malignancy : a research portfolio." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/9881.

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This thesis follows the research portfolio format and is carried out in part fulfilment of the academic component of the Doctorate in Clinical Psychology at the University of Edinburgh. An abstract provides an overview of the entire portfolio thesis. Chapter One contains a systematic review of published research investigating the experience of living with incurable forms of haematological malignancy. Chapter Two is an empirical study exploring adults’ experiences of living with follicular lymphoma while being maintained under the ‘watch and wait’ protocol. Both chapters are prepared for submis

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47

Maher, Michael. "An epigenetic approach to fatty acid metabolism in haematological malignancies." Doctoral thesis, Universitat de Barcelona, 2021. http://hdl.handle.net/10803/673704.

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The role of fatty acids to overcome stress and contribute to disease progression is becoming increasingly evident in haematological diseases. Further, epigenetic factors play an important role in the aetiology of myelodysplastic syndromes (MDS) and the transformation to secondary acute myeloid leukaemia (sAML). To investigate this in the MDS/sAML cell line, SKK-1, we employed a shRNA knockdown screen to target 912 epigenetic regulators. We then coupled this loss-of-function approach to a fatty acid metabolism-based assay with which we were able to cell-sort the SKK-1 cells based on the fatty a

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48

Orluvosu, O. C. "Haematological parameters in pregnant women hepatitis B infection in Nigeria." Thesis, Сумський державний університет, 2013. http://essuir.sumdu.edu.ua/handle/123456789/32841.

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Hepatitis B is a viral infection, a DNA hepadna virus type 1 and it is one of the most common serious liver diseases encountered in pregnant women. It is endemic worldwide. Approximately, 350 million people are chronic carriers and only 2% will spontaneously develop antibodies enough to clear the virus from their system according to studies carried out in Nigeria. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/32841

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49

Berard, Raymond. "Psychiatric aspects of haematological malignant disease : the Groote Schuur experience." Master's thesis, University of Cape Town, 1992. http://hdl.handle.net/11427/25946.

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50

Chan, Yuk-yin. "Haematological and molecular studies of Thalassaemias in Hong Kong Chinese /." Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19657882.

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