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Journal articles on the topic 'Haematological adaptations'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Rodríguez, Ferran A., Josep L. Ventura, Mireia Casas, et al. "Erythropoietin acute reaction and haematological adaptations to short, intermittent hypobaric hypoxia." European Journal of Applied Physiology 82, no. 3 (2000): 170–77. http://dx.doi.org/10.1007/s004210050669.

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Tobin, Barbara, Guillaume Costalat, and Gillian M. C. Renshaw. "Intermittent not continuous hypoxia provoked haematological adaptations in healthy seniors: hypoxic pattern may hold the key." European Journal of Applied Physiology 120, no. 3 (2020): 707–18. http://dx.doi.org/10.1007/s00421-020-04310-y.

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3

Dänicke, Sven, Ulrich Meyer, Janine Winkler, et al. "Haematological and immunological adaptations of non-pregnant, non-lactating dairy cows to a high-energetic diet containing mycotoxins." Archives of Animal Nutrition 70, no. 1 (2015): 1–16. http://dx.doi.org/10.1080/1745039x.2015.1117561.

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4

Montero, David, Adrian Cathomen, Robert A. Jacobs, et al. "Haematological rather than skeletal muscle adaptations contribute to the increase in peak oxygen uptake induced by moderate endurance training." Journal of Physiology 593, no. 20 (2015): 4677–88. http://dx.doi.org/10.1113/jp270250.

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5

Hervant, F., J. Mathieu, and J. Durand. "Behavioural, physiological and metabolic responses to long-term starvation and refeeding in a blind cave-dwelling (Proteus anguinus) and a surface-dwelling (Euproctus asper) salamander." Journal of Experimental Biology 204, no. 2 (2001): 269–81. http://dx.doi.org/10.1242/jeb.204.2.269.

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The effects of long-term starvation and subsequent refeeding on haematological variables, behaviour, rates of oxygen consumption and intermediary and energy metabolism were studied in morphologically similar surface- and cave-dwelling salamanders. To provide a hypothetical general model representing the responses of amphibians to food stress, a sequential energy strategy has been proposed, suggesting that four successive phases (termed stress, transition, adaptation and recovery) can be distinguished. The metabolic response to prolonged food deprivation was monophasic in the epigean Euproctus

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6

Watts, Eric. "Haematological adaptation to exercise." Clinical Hemorheology and Microcirculation 12, no. 4 (1992): 499–503. http://dx.doi.org/10.3233/ch-1992-12401.

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7

Corm, Selim, Ariane Leroyer, Mathieu Wemeau, et al. "A Retrospective Survey of Imatinib Mesylate Treatment for Chronic Myeloid Leukemia in a Northern France Region." Blood 108, no. 11 (2006): 4800. http://dx.doi.org/10.1182/blood.v108.11.4800.4800.

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Abstract Objective: To describe the use and results of imatinib mesylate (IM) treatment for chronic myeloid leukemia (CML) in the Nord-Pas de Calais Region in Northern France (~ 4 millions inhabitants). Methods: we identified all IM treated patients (pts) within the population of all confirmed diagnosis of CML occurred during the period 1985–2004. IM resistance (haematological and cytogenetic imatinib failure and suboptimal response) was evaluated according to the European LeukemiaNet consensus. Results: 302 pts (38.6% of the global cohort of diagnosis) were included in this retrospective stud

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STEPHENSON, R., D. L. TURNER, and P. J. BUTLER. "The Relationship Between Diving Activity and Oxygen Storage Capacity in the Tufted Duck (Aythya Fuligula)." Journal of Experimental Biology 141, no. 1 (1989): 265–75. http://dx.doi.org/10.1242/jeb.141.1.265.

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For a period of 6 months, a group of eight tufted ducks (‘control’ ducks) were kept on a shallow outdoor pond and performed short dives to obtain food (maximum depth, 0.65 m; observed mean duration, 10.9 ± 0.54s). At the same time, a group of seven tufted ducks (‘dive-trained’ ducks) were kept on an adjacent deeper and partly covered pond, and performed ‘extended’ dives under the surface mesh in order to feed (maximum distance to food, 10m; observed mean dive distance, 6.0 ± 0.25 m; observed mean duration, 24.8 ± 0.58 s). At the end of this time, the calculated total usable oxygen store was ap

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9

Savourey, Gustave, Nathalie Garcia, Yves Besnard, Angélique Guinet, Anne-Marie Hanniquet, and Jacques Bittel. "Pre-adaptation, adaptation and de-adaptation to high altitude in humans: cardio-ventilatory and haematological changes." European Journal of Applied Physiology and Occupational Physiology 73, no. 6 (1996): 529–35. http://dx.doi.org/10.1007/bf00357675.

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10

Dyomshina, O. O., M. I. Koloda та G. O. Ushakova. "Hepato- and hemato-protective properties of α-ketoglutarate under the combined effect of water-immobilization and emotional stress". Regulatory Mechanisms in Biosystems 9, № 4 (2018): 508–13. http://dx.doi.org/10.15421/021876.

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This article presents the results of the combined effect of water-immobilization and emotional stress on haematological and morphological parameters of blood and liver status of rats in conditions of correction of the disorders using by α-ketoglutarate. Experimental combined stress was induced by the interchangeable effect of dry immobilization and immersion in water for 3 days under constant illumination using an artificial lighting lamp of 1,000 lux., thus achieving a combined effect of stress. Physiological adaptation and administration of 5 mg/kg of body weight of α-ketoglutarate lasted 14

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11

Ozolua, R. I., E. K. I. Omogbai, A. B. Famodu, A. B. Ebeigbe, and O. I. Ajayi. "Haematological influences of potassium adaptation in normotensive and renally-hypertensive Wistar rats." British Journal of Biomedical Science 59, no. 2 (2002): 80–84. http://dx.doi.org/10.1080/09674845.2002.11783639.

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12

Giri, Arup, Vijay Kumar Bharti*, Sahil Kalia, and Bhuvnesh Kumar. "Cardiovascular biomarkers of high altitude adaptation: Selection aid for livestock breeding." International Journal of Bioassays 5, no. 12 (2016): 5146. http://dx.doi.org/10.21746/ijbio.2016.12.007.

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The efficiency of oxygen usage and energy metabolism is important for high-altitude adaptation and optimum performance of animals. With regards to adaptation and productivity of high yielder animals, high-altitude stress (hypobaric-hypoxia, cold stress) is a primary concern at high altitude. The cardiovascular system is an essential link in the transport of oxygen from the air to the mitochondria, and it, therefore, has an important role in acclimatisation and adaptation to the oxygen depleted environment of high altitude. These pathophysiological changes belong to the morphological, functiona

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13

Skouby, Arne P. "Haematologic Adaptation in Patients with Chronic Bronchitis and Pulmonary Insufficiency." Acta Medica Scandinavica 199, no. 1-6 (2009): 185–90. http://dx.doi.org/10.1111/j.0954-6820.1976.tb06714.x.

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14

Fazio, F., S. Marafioti, F. Arfuso, G. Piccione, and C. Faggio. "Comparative study of the biochemical and haematological parameters of four wild Tyrrhenian fish species." Veterinární Medicína 58, No. 11 (2013): 576–81. http://dx.doi.org/10.17221/7139-vetmed.

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A characteristic feature of fish is the wide physiological range of blood parameters and also the large individual variations. The aim of this study was to compare the haematological profile, glucose and lactate levels of four teleost fish species (Gobius niger, Mugil cephalus, Sparus aurata, Dicentrarchus labrax) and to establish the similarities and differences between these species which are widely present in the Tyrrhenian Sea. To this end, glucose, lactate and complete haematological profiles were determined for 25 fish from each species. Statistical analysis confirmed statistical differe

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15

PD, Katsoulos, N. Roubies, N. Panousis, E. Christaki, P. Karatzanos, and H. Karatzias. "Effects of long term feeding dairy cows on a diet supplemented with clinoptilolite on certain haematological parameters ." Veterinární Medicína 50, No. 10 (2012): 427–31. http://dx.doi.org/10.17221/5644-vetmed.

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The effect of the dietary inclusion of clinoptilolite on the haematological parameters of dairy cows has not been studied yet; however in mice, prolonged zeolite administration causes disturbances in the adaptation of erythropoiesis in periods of increased demands. The aim of the present study was to investigate whether the long term supplementation of two levels (1.25 and 2.5%) of clinoptilolite in the concentrate feed of dairy cows has any effect on their haematological parameters. Fifty-two clinically healthy Holsteincows were randomly assigned to one of three groups according to their age

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16

Tajchman, K. "Selected haematological indices in farmed male fallow deer (Dama dama) depending on the different conditions during the wintering period." Veterinární Medicína 64, No. 9 (2019): 379–85. http://dx.doi.org/10.17221/3/2019-vetmed.

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Fallow deer (Dama dama) are the most common breeding species among farmed cervids in Poland. Monitoring the animals’ health, nutritional status, and welfare are highly important aspects in their breeding. Haematological variables are important indicators for comparing the physiological status of the animals and for monitoring the changes in the organism related to the adaptation to the breeding conditions. The aim of this study was to assess the impact of the day’s length and the total protein content in the diet for the farmed fallow deer on the selected haematological variables. The study de

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17

Karić, Ernes, Aida Hodžić, Amir Zahirović, Amina Hrković-Porobija, and Husein Orhan. "Biochemical and haematological parameters in dogs with Cushing’s syndrome." Veterinarska stanica 52, no. 4 (2021): 413–19. http://dx.doi.org/10.46419/vs.52.4.5.

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The exposure of the body to stress, regardless of whether it comes from physical, chemical or emotional stimuli from the environment, causes an inadequate adaptation of the organisms which can contribute to the development of various diseases. Abnormally high blood concentrations of cortisol, known as stress hormone, lead to the development of a hormonal disorder called hyperadrenocorticism or Cushing’s syndrome. In the majority of cases, Cushing’s syndrome is diagnosed when symptoms are apparent, and screening endocrinological test confirms the existence either of increased cortisol productio

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18

Janicki, Bogdan, Anna Kochowicz, Mateusz Buzała, and Wiesław Krumrych. "Variability of Selected Clinical and Haematological Indices in Young Stallions During 100-Day Performance Test." Bulletin of the Veterinary Institute in Pulawy 57, no. 1 (2013): 91–96. http://dx.doi.org/10.2478/bvip-2013-0017.

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AbstractThe study was conducted on 20 clinically healthy stallions, aged 3-4 years. The evaluation of the degree of adaptation of stallions to exercise loads in the course of a 100-d training programme was conducted three times: (I) - on the 1st d of training, (II) - on the 46th d of training, and (III) - on the 97th d of training. Rectal temperature (T) and number of heart and respiratory rates were measured. Blood was sampled before exercise (1), after exercise (2), and 30 min after rest (3). The following indices were determined in the blood: concentration of haemoglobin, haematocrit level,

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19

Bhatkar, N. V. "Chromium (III) induced haematological alterations in Indian common carp, Labeo rohita (Ham.)." Journal of Applied and Natural Science 3, no. 2 (2011): 258–63. http://dx.doi.org/10.31018/jans.v3i2.192.

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The principle source of chromium in water bodies is discharged from industries which use large amount of chromates or dichromates. The freshwater fish, Labeo rohita was used as a model in the present studies to investigate the responses to chromium metal salt contamination in water bodies as it is the most common fish consumed widely in India. Haematological tests were carried out as these are the important diagnostic tools and are equally valuable as indicators of disease or stress due to pollutants and environmental fluctuations. The fishLabeo rohita were exposed to sublethal concentration o

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20

Voloshchuk, O. M., T. V. Luchyk, and G. P. Kopylchuk. "Indicators of immunoreactivity in rats under conditions of different nutrition regimen." Animal Biology 23, no. 1 (2021): 12–17. http://dx.doi.org/10.15407/animbiol23.01.012.

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The research deals with the integral haematological indices such as markers of immunoreactivity and phagocytic activity of neutrophils in animals kept in conditions of a nutrient imbalance. The animals were divided into four experimental groups: I — animals receiving full-value semi-synthetic ration (control group); II — animals receiving low-protein ration (LPR); III — animals receiving high-sucrose diet (HS); IV — animals receiving low-protein/high-sucrose diet (LPR/HS). It has been found that in animals kept in conditions of nutritional protein deficiency there was a disturbance of the spec

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21

Kumar, Ch Manoj, K. S. Keerthi Vyas, and Y. Sai Krishna. "Clinical profile of dengue fever with severe thrombocytopenia and its complications: a retrospective study at a tertiary care hospital in South India." International Journal of Research in Medical Sciences 5, no. 5 (2017): 1751. http://dx.doi.org/10.18203/2320-6012.ijrms20171543.

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Background: Dengue haemorrhagic fever is a potentially lethal illness that is universally prevalent in the tropics and has become a major health concern globally in recent decades. The clinical manifestation of dengue infection varies from asymptomatic to severe life threatening illness in the form of DHF/DSS. Dengue haemorrhagic fever or DSS may be fatal in 40% to 50% of untreated patients. A hallmark of dengue infection is severe thrombocytopenia which causes concern for the patients and treating doctors. The objective of this study was to correlate clinical profile during the evolution of d

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22

Habibu, B., MU Kawu, HJ Makun, et al. "Influence of sex, reproductive status and foetal number on erythrocyte osmotic fragility, haematological and physiologic parameters in goats during the hot-dry season." Veterinární Medicína 59, No. 10 (2014): 479–90. http://dx.doi.org/10.17221/7778-vetmed.

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The current study was aimed at evaluating the effect of heat stress (during the hot-dry period) on some physiological variables, haematology and erythrocyte osmotic fragility (EOF) in bucks, pregnant (single and twin) and lactating Red Sokoto (RS) goats. Forty apparently healthy adult goats were used for the study and were allotted to four groups [bucks (n = 10), pregnant (n = 10) dry (n = 10), and lactating (n = 10) does]. The pregnant goats were further re-grouped according to number of foetuses (single foetus, n = 5 and twins, n = 5). The temperature-humidity index and physiological variabl

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23

Bird, Martin C., Andrew G. Bosanquet, Susan Forskitt, and Edward D. Gilby. "Semi-micro adaptation of a 4-day differential staining cytotoxicity (DiSC) assay for determining the in-vitro chemosensitivity of haematological malignancies." Leukemia Research 10, no. 4 (1986): 445–49. http://dx.doi.org/10.1016/0145-2126(86)90075-5.

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24

Lubrano, Carla, Giuseppe Valacchi, Palma Specchia, et al. "Integrated Haematological Profiles of RedoxStatus, Lipid, and Inflammatory Protein Biomarkers in Benign Obesity and Unhealthy Obesity with Metabolic Syndrome." Oxidative Medicine and Cellular Longevity 2015 (2015): 1–14. http://dx.doi.org/10.1155/2015/490613.

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The pathogenesis of obesity (OB) and metabolic syndrome (MetS) implies free radical-, oxidized lipid- (LOOH-), and inflammatory cytokine-mediated altered pathways in target organs. Key elements of the transition from benign OB to unhealthy OB+MetS remain unclear. Here, we measured a panel of redox, antioxidant, and inflammation markers in the groups of OB patients (67 with, 45 without MetS) and 90 controls. Both OB groups displayed elevated levels of adipokines and heavy oxidative stress (OS) evidenced by reduced levels of glutathione, downregulated glutathione-S-transferase, increased 4-hydro

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25

Boslooper, Karin, Peter Joosten, Nic J. G. M. Veeger, et al. "A Significant Better Two Year Survival in the Very Elderly Patients with a Diffuse Large B-Cell Lymphoma (DLBCL) Who Did Complete Standard Therapy: A Population-Based Cohort Study On Treatment, Toxicity and Outcome." Blood 120, no. 21 (2012): 2642. http://dx.doi.org/10.1182/blood.v120.21.2642.2642.

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Abstract Abstract 2642 Introduction With the aging of the population clinicians are increasingly confronted with elderly, often frail, patients with a DLBCL. While the very elderly patients, defined by the age of ≥75 year, are often excluded from clinical trials, only few prospective data in the rituximab-era are available on the outcome in this patient cohort. To asses efficacy, tolerability and safety of standard intensive rituximab-containing therapy in those patients, a descriptive population-based, cohort study was performed. Detailed information on treatment, toxicity and outcome in all

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26

Straková, E., P. Suchý, I. Herzig, V. Šerman, and N. Mas. "The long-term administration of a clinoptilolite-supplemented feed to layers and its effect on performance, haematological parameters and metabolic profile." Czech Journal of Animal Science 53, No. 5 (2008): 212–18. http://dx.doi.org/10.17221/311-cjas.

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120 selected layers (Bovans Goldline hybrid) aged 19 weeks with an average weight of 1 735 g were divided into two balanced groups: control group (Group C) and experimental (Group E). Layers were reared in three-tier cages with automatic watering, manual feeding, and at controlled light and temperature regimens. One cage accommodated two layers, the floor surface area was 0.1125 m<sup>2</sup> per layer. The experiment started after a 20-day adaptation period with layers aged 22 weeks (Week 22) and ended when layers were 68 weeks old (Week 68). In a period of initiation (i.e. Weeks

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27

Rafikova, Elmira R. "Acute Oral Toxicity of Vetom 21.77 Based on Duddingtonia Flagrans in Broiler Chickens." Macedonian Veterinary Review 42, no. 1 (2019): 87–93. http://dx.doi.org/10.2478/macvetrev-2018-0031.

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AbstractA 14-d study was undertaken to test the acute toxicity of a new preparation Vetom 21.77 based on the predacious fungus Duddingtonia flagrans. A total of 40 healthy 5-day-old broiler chickens (Hubbard F15, 100 ± 5 g), that had previously gone through a required 5-days adaptation to the environment, were orally dosed with the drug for 5 consecutive days at different doses, after which their health status was assessed daily up to the end of the experiment. According to the results, no substantial changes in the physiological state of the chickens were detected during the experiment. Inter

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Witkowska-Piłaszewicz, Olga, Piotr Bąska, Michał Czopowicz, et al. "Anti-Inflammatory State in Arabian Horses Introduced to the Endurance Training." Animals 9, no. 9 (2019): 616. http://dx.doi.org/10.3390/ani9090616.

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Development of an anti-inflammatory state during physical training has been postulated in both human and equine athletes, but it is not completely understood. The aim of this study was to investigate whether endurance training changes pro- and anti-inflammatory cytokine profiles within a 20-week training season in young inexperienced endurance horses. Nine Arabian horses were examined in this prospective 20-week follow-up study. Blood samples were analysed 5 times monthly, at rest and after training sessions. Routine haematological examinations were performed. Cytokine patterns including IL-1β

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29

Rad S. M., Ali Hosseini, Joshua Colin Halpin, Mojtaba Mollaei, Samuel W. J. Smith Bell, Nattiya Hirankarn, and Alexander D. McLellan. "Metabolic and Mitochondrial Functioning in Chimeric Antigen Receptor (CAR)—T Cells." Cancers 13, no. 6 (2021): 1229. http://dx.doi.org/10.3390/cancers13061229.

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Chimeric antigen receptor (CAR) T-cell therapy has revolutionized adoptive cell therapy with impressive therapeutic outcomes of >80% complete remission (CR) rates in some haematological malignancies. Despite this, CAR T cell therapy for the treatment of solid tumours has invariably been unsuccessful in the clinic. Immunosuppressive factors and metabolic stresses in the tumour microenvironment (TME) result in the dysfunction and exhaustion of CAR T cells. A growing body of evidence demonstrates the importance of the mitochondrial and metabolic state of CAR T cells prior to infusion into pati

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30

Collins, Geoffrey Mark, Timothy Darren Clark, and Alexander Guy Carton. "Physiological plasticity v. inter-population variability: understanding drivers of hypoxia tolerance in a tropical estuarine fish." Marine and Freshwater Research 67, no. 10 (2016): 1575. http://dx.doi.org/10.1071/mf15046.

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Physiological plasticity and inter-population variability (e.g. local adaptation) are two key drivers in determining the capacity for species to cope with environmental change, yet the relative contribution of each parameter has received little attention. Here, we investigate the acclimation potential of two geographically distinct populations of the barramundi (Lates calcarifer) to diel hypoxia. Fish were exposed to a daily hypoxia challenge of 6h below 62% saturation, down to a minimum of 10±5% saturation, followed by a return to normoxia. Respiratory and haematological variables were assess

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Harmand, Pierre-Olivier, and Jérôme Solassol. "Thiopurine Drugs in the Treatment of Ulcerative Colitis: Identification of a Novel Deleterious Mutation in TPMT." Genes 11, no. 10 (2020): 1212. http://dx.doi.org/10.3390/genes11101212.

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Chronic inflammatory bowel disease (IBD) includes Crohn’s disease and ulcerative colitis. Both are characterized by inflammation of part of the digestive tract lining. Azathioprine (AZA) is a well-known immunosuppressant that has been known for many years for its ability to provide long-term disease remission in IBDs, but has important side effects, most of which are related to a single nucleotide polymorphism in the gene for thiopurine methyltransferase (TPMT), which ensures the degradation and efficacy of AZA. Since a direct correlation between TPMT gene polymorphisms and the haematological

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32

Giammarco, M., I. Fusaro, G. Vignola, et al. "Effects of a single injection of Flunixin meglumine or Carprofen postpartum on haematological parameters, productive performance and fertility of dairy cattle." Animal Production Science 58, no. 2 (2018): 322. http://dx.doi.org/10.1071/an16028.

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The objective of the present research was to evaluate the effects of a single injection of Flunixin meglumine (FM) or Carprofen postpartum on haematological indicators, productive performance and fertility of Italian Friesian dairy cattle. In total, 60 cows, including 42 multiparous and 18 primiparous, were assigned to one of the following three treatments: (1) FM (2.2 mg i.m./kg of bodyweight (BW); Meflosyl 50 mg/mL), (2) Carprofen (CA; 1.4 mg s.c./kg of BW; Rymadil 50 mg/mL) or (3) saline (control) at 2.0 mL s.c./45.5 kg of BW. All treatments were administrated by a single injection within 1

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33

Cappelli, Katia, Massimo Amadori, Samanta Mecocci, Arianna Miglio, Maria Teresa Antognoni, and Elisabetta Razzuoli. "Immune Response in Young Thoroughbred Racehorses under Training." Animals 10, no. 10 (2020): 1809. http://dx.doi.org/10.3390/ani10101809.

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Training has a great impact on the physiology of an athlete and, like all stressful stimuli, can trigger an innate immune response and inflammation, which is part of a wider coping strategy of the host to restore homeostasis. The Thoroughbred racehorse is a valid animal model to investigate these changes thanks to its homogeneous training and highly selected genetic background. The aim of this study was to investigate modifications of the innate immune response and inflammation in young untrained Thoroughbred racehorses during the first training season through haematological and molecular inve

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Soares, O. A. B., G. C. Ferraz, P. Trigo, et al. "Comparison between specific and nonspecific tests for evaluating the physical fitness of show jumping horses." Comparative Exercise Physiology 12, no. 3 (2016): 131–40. http://dx.doi.org/10.3920/cep160018.

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Show jumping is a century-old Olympic sport performed worldwide. However, despite the prominence of this sport, there is currently no satisfactory evaluation of the physical fitness of its horses. Our study compared two standardised exercise tests (specific and nonspecific for show jumpers) to determine the importance of a show jumping specific evaluation test. Sixteen horses were divided into two performance groups (high and low performance), and all horses performed standardised exercise tests without jumps (SET1) and with jumps (SET2). Heart rate, blood lactate, glucose, blood gas, haematol

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35

Zembron-Lacny, Agnieszka, Anna Tylutka, Eryk Wacka, et al. "Intermittent Hypoxic Exposure Reduces Endothelial Dysfunction." BioMed Research International 2020 (August 19, 2020): 1–10. http://dx.doi.org/10.1155/2020/6479630.

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Intermittent exposure to hypoxia (IHE) increases the production of reactive oxygen and nitrogen species as well as erythropoietin (EPO), which stimulates the adaptation to intense physical activity. However, several studies suggest a protective effect of moderate hypoxia in cardiovascular disease (CVD) events. The effects of intense physical activity with IHE on oxi-inflammatory mediators and their interaction with conventional CVD risk factors were investigated. Blood samples were collected from elite athletes (control n=6, IHE n=6) during a 6-day IHE cycle using hypoxicator GO2 altitude. IHE

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36

Wechalekar, Ashutosh D., Hugh J. B. Goodman, Julian D. Gillmore, et al. "Efficacy of Risk Adapted Cyclophosphamide, Thalidomide and Dexamethasone in Systemic AL Amyloidosis." Blood 106, no. 11 (2005): 3496. http://dx.doi.org/10.1182/blood.v106.11.3496.3496.

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Abstract The prognosis for advanced AL amyloidosis (AL) with conventional treatment remains very poor and stem cell transplantation has unacceptably high mortality (TRM). Single agent thalidomide in standard doses is poorly toleranated and has low response rates in AL (Dispenzieri et al, Amyloid10:247; 2003) and few data on the role of thalidomide based combination chemotherapy in AL are available. We report experience with a risk adapted thalidomide based combination using cyclophosphamide and dexamethasone (CTD) in 43 patients with AL amyloidosis at the National Amyloidosis Centre, UK. The r

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37

Ludwig, Heinz, Zdenek Adam, Roman Hajek, et al. "Recovery of Renal Impairment by Bortezomib-Doxorubicin-Dexamethasone (BDD) in Multiple Myeloma (MM) Patients with Acute Renal Failure. Results from an Ongoing Phase II Study." Blood 110, no. 11 (2007): 3603. http://dx.doi.org/10.1182/blood.v110.11.3603.3603.

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Abstract Acute renal failure (ARF) is a severe complication of MM often leading to permanent renal dysfunction and dependence on chronic hemodialysis. Reversal of kidney failure can only be achieved by fast and substantial suppression of pathogenic light-chains by effective anti-MM therapy. In a previous pilot study we were able to reverse renal impairment with bortezomib based therapy in 5 of 9 pts (Haematologica 2007). Here, we present preliminary data from an ongoing phase II study in pts with ARF using the BDD regimen. Up to now 37 pts with MM induced ARF (age: median 64 yrs, range 41–82 y

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Oliva, Esther Natalie, Roberto Latagliata, Giorgina Specchia, et al. "Quality of Life Scores Have a Prognostic Significance In Elderly AML Patients." Blood 112, no. 11 (2008): 1949. http://dx.doi.org/10.1182/blood.v112.11.1949.1949.

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Abstract INTRODUCTION: Quality-of-life (QOL) is a patient-related outcome of increasing interest in onco-haematological setting. However, there are very few reports on QOL in elderly patients with Acute Myeloid Leukemia (AML). Prognosis of AML in elderly patients is still poor with a median survival of 9–12 months and less than 20% survival at 5 years. This is due to age-related factors and also to a higher incidence of poor-risk cytogenetics, multi-drug resistance and treatment-related mortality. The measurement of QOL at diagnosis may provide useful information regarding patient preferences

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De Matteis, Serena, Silvia Carloni, Roberta Napolitano, et al. "Targeting Lon Protease Activity Promotes Growth Inhibition and Apoptosis in Acute Myeloid Leukemia Cell Lines." Blood 124, no. 21 (2014): 5130. http://dx.doi.org/10.1182/blood.v124.21.5130.5130.

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Abstract INTRODUCTION Acute myeloid leukemia (AML) is a progressive malignant disorder of the myeloid lineage of hematopoietic cells, where overall three-year survival is below 20% for patients above 65 years (1). Therapy resistance or relapsed are the main causes of mortality among these patients. The functional changes that affect mitochondria may contribute to the development of cancer (2). The mitochondrial Lon, ubiquitously expressed in human cells and tissues, seems to be involved in protein quality control and stress response pathways in mitochondria. Several stress conditions induce an

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Jaksic, Ozren, Marija Ivic, Rajko Kusec, et al. "Prognostic Value of TTM with TTM Distribution and Ball Score in Relapsed/Refractory Ibrutinib Treated B-CLL - in the Real-World Setting." Blood 136, Supplement 1 (2020): 14–15. http://dx.doi.org/10.1182/blood-2020-143030.

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There is a high number of clinical and biological parameters with impact on prognosis in B-CLL and number of successful prognostic models were developed (clinical stages, CLL IPI, MDACC score, etc.). However, rapidly changing therapeutic landscape with more successful targeted terapines with different modes of action, render most of these models developed in era of chemo and chemoimmunotherapy less useful. Recently simple prognostic score (BALL score) based on 4 parameters (LDH&gt;UNL, B2microglobulin&gt;5mcg/l, Hemoglobin&lt;120 g/l in males and 110g/l in females, and time from st

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Ludwig, Heinz, Elisabeth Rauch, Thomas Kuehr, et al. "Lenalidomide and Dexamethasone for Acute Light Chain-Induced Renal Failure: Final Results of a Phase II Study." Blood 124, no. 21 (2014): 3484. http://dx.doi.org/10.1182/blood.v124.21.3484.3484.

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Abstract Background: Acute renal failure (ARF) is a frequent complication of multiple myeloma (MM) and most frequently due to clonotypic light chains (LC) causing cast nephropathy, which is associated with fast deterioration of renal function, increased risk for infections and shortened survival. Here we present the final results of a phase II study employing lenalidomide-dexamethasone as treatment for patients with acute light-chain induced ARF. Patients and methods: 35 patients with LC-induced ARF have been enrolled. Cast nephropathy was confirmed in all 15 patients who had a renal biopsy. P

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Akerman, Ashley P., Samuel JE Lucas, Chris J. Baldi, Rajesh Katare, and James D. Cotter. "Haematological adaptations to High Intensity Interval Training (HIIT) in temperate and hot environments." Extreme Physiology & Medicine 4, S1 (2015). http://dx.doi.org/10.1186/2046-7648-4-s1-a145.

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Whitburn, Jessica, and Claire M. Edwards. "Metabolism in the Tumour-Bone Microenvironment." Current Osteoporosis Reports, July 28, 2021. http://dx.doi.org/10.1007/s11914-021-00695-7.

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Abstract Purpose of Review For solid tumours such as breast and prostate cancer, and haematological malignancies such as myeloma, bone represents a supportive home, where the cellular crosstalk is known to underlie both tumour growth and survival, and the development of the associated bone disease. The importance of metabolic reprogramming is becoming increasingly recognised, particularly within cancer biology, enabling tumours to adapt to changing environments and pressures. This review will discuss our current understanding of metabolic requirements and adaptations within the tumour-bone mic

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Patel, Vruti, and J. D. Lakhani. "A Cross Sectional Study to Assess the Status of Hemoglobin and Other Blood Indices among Pregnant Women Attending Tertiary Care Hospital of Vadodara." Journal of Pharmaceutical Research International, August 16, 2021, 106–11. http://dx.doi.org/10.9734/jpri/2021/v33i41a32308.

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Introduction: A number of adaptations happen in the anatomy, physiology and metabolic processes within the mother which aids in successful progression of the pregnancy. The different blood indices such as haemoglobin concentration, packed cell volume (PCV), red blood cell count; total WBC count etc. can be measured to evaluate haematological status in a pregnant woman. The hematological profile of the pregnant women has an impact on both pregnancy and its outcome. Anaemia in pregnancy can be leads to morbidity and mortality in mother and fetus. The current study was designed to determine the v

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Christou, G., E. Pagourelias, A. Deligiannis, and E. Kouidi. "Exploring the physiological determinants of marathon performance." European Journal of Preventive Cardiology 28, Supplement_1 (2021). http://dx.doi.org/10.1093/eurjpc/zwab061.370.

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Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – EU funding. Main funding source(s): ESPA 2014-2020 Background/Introduction: Long-time endurance exercise training leads to cardiovascular, respiratory, haematological and neuromuscular adaptations. The relative contribution of these adaptations to running performance in long-distance races remains to be elucidated in an integrative manner. Purpose The study of the relationship of marathon performance with anthropometric, cardiorespiratory and haematological adaptations. Methods Thirty-one marathon runners (26 males, a

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de Beauchamp, Lucie, Ekaterini Himonas, and G. Vignir Helgason. "Mitochondrial metabolism as a potential therapeutic target in myeloid leukaemia." Leukemia, September 24, 2021. http://dx.doi.org/10.1038/s41375-021-01416-w.

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AbstractWhile the understanding of the genomic aberrations that underpin chronic and acute myeloid leukaemia (CML and AML) has allowed the development of therapies for these diseases, limitations remain. These become apparent when looking at the frequency of treatment resistance leading to disease relapse in leukaemia patients. Key questions regarding the fundamental biology of the leukaemic cells, such as their metabolic dependencies, are still unresolved. Even though a majority of leukaemic cells are killed during initial treatment, persistent leukaemic stem cells (LSCs) and therapy-resistan

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Olenovych, O. A. "NONSPECIFIC ADAPTATIONAL REACTIONS OF ORGANISM IN PATIENTS WITH HYPOTHYROIDISM ACCORDING TO INTEGRAL HAEMATOLOGICAL INDICES." Clinical & experimental pathology 13, no. 1 (2014). http://dx.doi.org/10.24061/1727-4338.xiii.1.47.2014.22.

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Oguntunji, Abel, Opeyemi Adetola Oladejo, Mathew Oluseyi Ayoola, Lopemi Opeoluwa Oriye, Opeyemi Olufemi Ogundijo, and Abiola Olufunke Ilufoye. "Multivariate Analysis of Thermal Adaptive Profile of Three Genetic Groups of Duck." Buletin Peternakan 44, no. 1 (2020). http://dx.doi.org/10.21059/buletinpeternak.v44i1.46595.

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Inherent thermal adaptation in livestock is an important economic trait that cannot be overlooked, most especially in animals reared in sub-optimal thermally stressful environments. The present study explored the possibility of using multifactorial discriminant analysis (DA) to separate two duck genera {Muscovy and Common (Mallard) ducks) and their hybrid (Mule ducks) to distinct genetic groups using physiological, haematological and biochemical parameters. Data were collected after exposure of ducks to solar radiation for 90 minutes (12.00 – 13.30 hours). The result of analysis of variance in

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SOUTO, Paula Lorena Grangeira, Eleonara Araújo BARBOSA, Edison MARTINS, et al. "Influence of season and external morphology on thermal comfort and physiological responses in bulls from two breeds adapted to a subtropical climate." Revista Brasileira de Saúde e Produção Animal 22 (2021). http://dx.doi.org/10.1590/s1519-99402122022021.

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ABSTRACT Animals in subtropical regions can be exposed to periods of thermal stress. Locally adapted breeds are especially important in this context, but these have little information available in their natural environments. The aim of this study was to assess whether season affects thermal comfort and physiological responses to increased temperatures of two breeds of bulls in a subtropical climate. Four Angus and four Crioulo Lageano bulls were used in this study. Body and testicles measurements, skin pigmentation and thickness, hair number, length and pigmentation, respiratory rate, panting

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