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Dissertations / Theses on the topic 'Haemophilus infection'

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Published: 28 May 2022

Last updated: 31 July 2025

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1

Lewis, David Arthur. "Potential virulence determinants in Haemophilus ducreyi infection." Thesis, Imperial College London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341930.

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2

Puig, Pitarch Carmen. "Nontypeable Haemophilus influenzae: colonization, infection and biofilm formation." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/311616.

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Haemophilus influenzae is an opportunistic pathogen that forms part of the human nasopharyngeal microbiota. This microorganism is classified into encapsulated and nonencapsulated or nontypeable (NTHi) isolates, depending on the presence of a polysaccharide capsule. Although H. influenzae is a common respiratory commensal, it is also able to cause several infections, especially in patients with comorbidities. The most common respiratory infections in which H. influenzae can be identified as the main etiological agent are exacerbations in patients with Chronic Obstructive Pulmonary Disease (COPD

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3

TOURNEMIRE, ALAIN. "Infections materno-foetales a haemophilus et pneumocoques." Toulouse 3, 1989. http://www.theses.fr/1989TOU31112.

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4

Walker, Woolf. "Cilia, nitric oxide and non-typeable Haemophilus influenzae biofilm infection." Thesis, University of Southampton, 2015. https://eprints.soton.ac.uk/382963/.

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5

Silfverdal, Sven-Arne. "Invasive Haemophilus influenzae infection and breastfeeding : aspects of epidemiology and immunology /." Linköping : Univ, 2001. http://www.bibl.liu.se/liupubl/disp/disp2001/med676s.pdf.

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6

Clarke, Jodie Louise, and n/a. "Regulation of Cytokines and Chemokines during Lung Infection with Nontypeable Haemophilus influenzae." University of Canberra. n/a, 2008. http://erl.canberra.edu.au./public/adt-AUC20081210.084252.

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An animal model of respiratory infection was used to determine the effect of various factors, thought to influence the ability of the host to clear bacteria, on the host?s innate response to an NTHi lung infection. Mucosal immunisation with NTHi has previously been shown to enhance the clearance of NTHi from the lung in an animal model of infection through the increased recruitment of phagocytes. Comparisons of cytokine and chemokine kinetic profiles were made in order to determine differences between innate and acquired immune response and the way in which mucosal immunisation controls the in

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7

Foxwell, Alice Ruth, and n/a. "Mechanisms of immunity to nontypeable Haemophilus influenzae in the lung." University of Canberra. Applied Science, 1998. http://erl.canberra.edu.au./public/adt-AUC20060710.142114.

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Pulmonary infection caused by nontypeable Haemophilus influenzae (NTHi) is a significant cause of morbidity and mortality in both industrialised and developing countries. Previous work from this group resulted in the development of a respiratory model in rodents which has precipitated studies into the pathogenesis of infection by NTHi and investigation of the humoral and cellular mechanisms by which the bacteria are cleared from the lung. Comparison of mucosally immunised with non-immunised animals has demonstrated that not only are bacteria cleared more rapidly from the lungs, but there is a

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8

Ferre, Jean-François. "Prévention des infections graves chez les patients splénectomisés : enquête à propos de 246 patients de 1989 à 1996." Montpellier 1, 1998. http://www.theses.fr/1998MON11082.

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9

Leeuwen-Gorter, Annelies Danielle van. "Pathogenesis of Haemophilus influenzae respiratory infection in COPD patients effects of neutrophil defensins on the interaction of Haemophilus influenzae with airway epithelial cells /." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2002. http://dare.uva.nl/document/64756.

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10

BATUT, PATRICIA. "Surveillance epidemiologique - frequence et resistance - de streptococcus pneumoniae et haemophilus influenzae dans les infections respiratoires au c. H. U. De rangueil." Toulouse 3, 1989. http://www.theses.fr/1989TOU31702.

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11

PENARD, MARIE-CHRISTINE. "Prevention des infections a neisseria meningitidis et haemophilus influenzae : connaissances actuelles sur les vaccins polysaccharidiques." Nantes, 1989. http://www.theses.fr/1989NANT151M.

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12

Parillo, Carlo. "FUNCTIONAL CHARACTERIZATION OF ENVIRONMENTAL LACTATE UTILIZATION DURING NTHi in vitro INFECTION OF HUMAN EPITHELIA." Doctoral thesis, Università di Siena, 2018. http://hdl.handle.net/11365/1039777.

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Non-typeable Haemophilus influenzae (NTHi) is a small acapsulate gram-negative coccobacillus and a human restricted nasopharynx commensal. Nevertheless, it is the main cause of chronic obstructive pulmonary disease (COPD) exacerbation. A previous dual RNA-sequencing study highlighted the upregulation of an L-lactate permease gene, suggesting a role for environmental lactate during the infection. Furthermore, a strong downregulation of the sialic acid-specific tripartite ATP-independent periplasmic transporter (TRAP system) was reported, while a gene (pst) with 60% similarity with nanT, an N-ac

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13

Delvallez, Michel. "Sensibilite comparee de streptococcus pneumoniae (70 souches) et haemophilus influenzae (94 souches) vis-a-vis du cefaclor et de l'amoxycilline - acide clavulanique." Lille 2, 1990. http://www.theses.fr/1990LIL2M267.

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14

Leroy, Magali. "Genome-wide approach to vaccine target candidates identification against otitis media causing nontypeable Haemophilus influenzae." Paris 11, 2006. http://www.theses.fr/2006PA112260.

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Bien qu’il existe un vaccin contre haemophilus influenzae (hi) type b, aucun n’est disponible contre la forme non encapsulee (nthi) responsable d'infections du systeme respiratoire telle que l'otite de l'oreille moyenne. Cette infection entraine des sequelles auditives dans 20% des cas et reste la premiere cause de visite pediatrique dans les pays developpes. L’enjeu de ce travail a ete de developper un systeme permettant l'analyse de l'expression genomique durant les phases de l'infection. Et ce dans le but d’acquerir une meilleure comprehension de la pathogenese de nthi et d’identifier les a

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15

Dowling, Ruth Brigid. "The influence of pharmacological agents on Pseudomonas aeruginosa and Haemophilus influenzae infection of the respiratory mucosa in vitro." Thesis, Imperial College London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300382.

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16

Meloche, Michèle. "Development and application of a quantitative virulence assay for Haemophilus ducreyi in an in vivo model of infection." Thesis, University of Ottawa (Canada), 1993. http://hdl.handle.net/10393/10955.

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A temperature-dependant rabbit model of Haemophilus ducreyi infection was used as a quantitative virulence assay to evaluate the effect of host factors upon ulcerative cutaneous disease production. New Zealand White rabbits underwent inoculation with H. ducreyi strain #35000 either after iron loading, dexamethasone immunosuppression, prior infection or immunization. Chancroid-like disease was scored for severity, time, culture of lesions, and serologic response. In primary infections, culture-positive ulcerative lesions were consistently produced at and above 105 colony forming units inocula.

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17

Dhouib, Rabeb, Dk Seti Maimonah Pg Othman, Victor Lin, et al. "A Novel, Molybdenum-Containing Methionine Sulfoxide Reductase Supports Survival of Haemophilus influenzae in an In vivo Model of Infection." FRONTIERS MEDIA SA, 2016. http://hdl.handle.net/10150/622464.

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Haemophilus influenzae is a host adapted human mucosal pathogen involved in a variety of acute and chronic respiratory tract infections, including chronic obstructive pulmonary disease and asthma, all of which rely on its ability to efficiently establish continuing interactions with the host. Here we report the characterization of a novel molybdenum enzyme, TorZ/MtsZ that supports interactions of H. influenzae with host cells during growth in oxygen-limited environments. Strains lacking TorZ/MtsZ showed a reduced ability to survive in contact with epithelial cells as shown by immunofluorescenc

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18

Turkington, Christopher Jason Richard. "Investigation of the influence of phase variable restriction modification systems and lipooligosaccharide epitopes on resistance of Haemophilus influenzae to infection by bacteriophage." Thesis, University of Leicester, 2017. http://hdl.handle.net/2381/40031.

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The evolution of ON/OFF switching phase variable loci is presumed to have arisen due to the need for bacterial populations to cope with uncertain environments where selection fluctuates between opposing pressures. One such selection is believed to be the presence of bacteriophage. Bacteriophage can influence bacterial evolution by forcing the development of bacteriophage resistance mechanisms within bacterial populations. However, resistance mechanisms can often come at a cost, such as reduced survival against the immune responses. As such, phase variation may circumnavigate this cost by gener

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19

Bruant, Guillaume. "Etude de gènes fimbriaux de souches d'Haemophilus responsables d'infections génitales, materno-foetales et néonatales, et développement d'une méthode de typage moléculaire pour les souches d'Haemophilus." Tours, 2003. http://www.theses.fr/2003TOUR4009.

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L'opéron ghf a été caractérisé et son expression étudiée chez 6 souches cryptiques d'Haemophilus responsables d'infections génitales, materno-fœtales et néonatales. L'opéron est complet et son organisation génétique est identique à celle de l'opéron hif codant les fimbriae LKP mais il ne s'exprime pas en raison d'altérations dans sa région promotrice. Ceci a été confirmé par microscopie électronique et par l'étude des propriétés d'hémagglutination des souches cryptiques. La recherche d'autres gènes codant les fimbriae de ces souches a montré l'absence de gènes similaires à des gènes fimbriaux

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20

Williams, Bryan J. "Discovery and characterization of the HP2 phage in haemophilus influenzae." free to MU campus, to others for purchase, 2000. http://wwwlib.umi.com/cr/mo/fullcit?p9998524.

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21

Denicola-Seoane, Ana. "Studies on pyridine nucleotide-dependent processes in Haemophilus influenzae." Diss., Virginia Polytechnic Institute and State University, 1989. http://hdl.handle.net/10919/54514.

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Haemophilus influenzae and related species have a unique requirement for externally-provided NAD; therefore, several pyridine nucleotide-requiring enzymes become important for the survival of these pathogens. Haemophilus influenzae ATP:NMN adenylyltransferase was partially purified 15-fold with a 27% yield using dye affinity chromatography. Affinity chromatography was also used to purify NAD kinase from Haemophilus influenzae, 18-fold with a 32% yield. Substrate specificity studies of these enzymes demonstrated the enzymes to function with 3-acetylpyridine analogs of their respective substrat

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22

Hobb, Rhonda I. "Characterisation of a haemagglutinin from Haemophilus paragallinarum /." [St. Lucia, Qld.], 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18399.pdf.

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23

Hombrouck, Cécile. "Haemophilus influenzae, B-lactamase négative - "ampicilline résistants" : détection et étude de la résistance." Paris 5, 1999. http://www.theses.fr/1999PA05P172.

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24

Soulard, Raoulin D. "L'uréthrite masculine à haemophilus parainfluenzae existe-t-elle ?" Bordeaux 2, 1992. http://www.theses.fr/1992BOR2M160.

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25

Tsao, David L. "Serum resistance of an invasive nontypeable H. influenzae." Diss., Columbia, Mo. : University of Missouri-Columbia, 2004. http://hdl.handle.net/10355/5808.

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Thesis (M.S.)--University of Missouri-Columbia, 2004.<br>"December, 2004." The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Includes bibliographical references.

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26

Trumper, Bronwen Bauer. "TOXIC EFFECTS OF CULTURE SUPERNATANT FLUIDS OF HAEMOPHILUS PLEUROPNEUMONIAE IN VITRO AND IN VIVO (RESPIRATORY, SWINE, PLEUROPNEUMONIA)." Thesis, The University of Arizona, 1985. http://hdl.handle.net/10150/275412.

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27

Gousset, Nathalie. "Etude de facteurs d'adhésion de souches de Haemophilus responsables d'infections urogénitales, materno-foetales et néonatales." Tours, 1998. http://www.theses.fr/1998TOUR3310.

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Les Haemophilus sont la troisième cause d'infections materno-foetales et néonatales. Un groupe particulier de souches identifiées phénotypiquement le plus souvent comme des H. Influenzae de biotype IV non typables (pas de capsule détectée) constitue une espèce cryptique proche de H. Influenzae et de H. Haemolyticus. Ces bactéries apparaissent strictement inféodées au tractus génital et sont responsables d'infections génitales, materno-foetales et néonatales. Afin de comprendre comment ces souches de Haemophilus adhèrent aux cellules de l'hôte, nous avons étudié une collection de 19 souches cry

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28

Abdeldaim, Guma M. K. "PCR detection of Streptococcus pneumoniae and Haemophilus influenzae in pneumonia patients." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl.[distributör], 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-107931.

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29

Williams, M. D. "A study of the inter-relationships between immunosuppression, treatment and infective complications in haemophilic boys." Thesis, University of Liverpool, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381304.

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30

Telfer, Paul. "Clinical studies of hepatitis C virus infection in haemophilic patients." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388895.

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31

Evans, Jennifer Anne. "Blood borne virus infection and immune modulation in haemophilia A." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271543.

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32

Herreru-MartiÌnez, Esteban. "Hepatitis C and HIV co-infection in patients with haemophilia." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404936.

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33

Schilfgaarde, Muriel van. "Intercellular passage of epithelial cell layers a pathogenic mechanism for Haemophilus influenzae infections /." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2000. http://dare.uva.nl/document/82765.

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34

Strålin, Kristoffer. "Diagnostic methods for bacterial etiology in adult community-acquired pneumonia /." Linköping : Linköpings universitet, 2005. http://www.bibl.liu.se/liupubl/disp/disp2005/med918s.pdf.

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35

Ho, Derek K. "lgtC expression mediates complement resistance in nontypeable Haemophilus influenzae strain R2866 /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/9308.

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36

Watson, Michael E. "DNA mismatch repair and hypermutability in the physiology and pathogenesis of Haemophilus influenzae." Free to MU Campus, others may purchase, 2004. http://wwwlib.umi.com/cr/mo/fullcit?p3137763.

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37

Pornet, Laurence. "Infections O. R. L. Chez l'enfant de moins de huit ans." Paris 5, 1994. http://www.theses.fr/1994PA05P071.

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38

Young, Rosanna E. B. "The lipopolysaccharide of Haemophilus parainfluenzae." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:fc7b7bcc-ea89-4ded-bb65-a1f2879236ca.

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Haemophilus parainfluenzae (Hp) and H. influenzae (Hi) are closely related members of the Pasteurellaceae family and are common commensal bacteria of the human nasopharynx. Whilst Hi is frequently implicated in meningitis, otitis media and respiratory tract infections, reports of pathogenic behaviour by Hp are very rare. Lipopolysaccharide (LPS) is a key component of the Gram negative cell wall, and its structure influences the ability of Haemophilus to interact with the host and evade immune clearance. A better understanding of the differences in LPS structure between Hi and Hp could help to

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39

PREZIOSI, MARIE-PIERRE. "Prevention des infections a haemophilus influenzae de type b par la vaccination : etude de 400 nourrissons vaccines par le polyoside capsulaire couple a la proteine tetanique." Lyon 1, 1990. http://www.theses.fr/1990LYO1M044.

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40

Levayer, Sandrine. "Epidémiologie des souches de "Haemophilus influenzae" isolées de la flore nasopharyngée d'enfants atteints d'otite moyenne aigue͏̈." Paris 5, 1995. http://www.theses.fr/1995PA05P053.

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41

Bello, Ortí Bernardo. "Haemophilus parasuis host-pathogen interactions in the respiratory tract." Doctoral thesis, Universitat Autònoma de Barcelona, 2015. http://hdl.handle.net/10803/312855.

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En el sector veterinario, la enfermedad de Glässer es un proceso patogénico frecuente que conduce a pérdidas económicas considerables. Esta enfermedad es causada por Haemophilus parasuis. Aunque se ha llevado a cabo un esfuerzo importante hacia la comprensión de los factores que intervienen en la evolución de la enfermedad, la falta de completa protección de las vacunas comerciales sugieren que debe dirigirse más trabajo hacia el estudio de este proceso patogénico. Para aumentar el conocimiento en patogénesis desarrollamos una serie de experimentos. Es bien sabido que existen diferentes cepas

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42

Robinson, Esther Rhiannon. "Conjugative transfer and phylogeny of an antibiotic resistant haemophilus element, ICEHin1056." Thesis, University of Oxford, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572683.

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Antibiotic resistance in bacteria is a growing threat to global health. Many of the genes responsible for resistance are carried on mobile genetic elements which can be transferred laterally between strains and species. The most important of these are conjugative and mobilisable elements including plasmids and integrating and conjugating elements, ICEs. Haemophi/us influenzae is an important human pathogen, which was first identified as carrying antibiotic resistance genes in the 1970s. Much of this resistance is encoded by ICEHin1056, which is present in H. influenzae strains worldwide. The a

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43

Kunthalert, Duangkamol, and n/a. "Immunological and structural characterisation of the nontypeable Haemophilus influenzae vaccine protein OMP26." University of Canberra. Health Sciences, 2004. http://erl.canberra.edu.au./public/adt-AUC20060406.101830.

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Nontypeable Haemophilus influenzas (NTHi) is recognised as a significant human pathogen causing mild to severe respiratory tract infections. At present, no vaccine is available for prevention of infection caused by this pathogen. Several outer membrane proteins (OMPs) of NTHi and its lipooligosaccharide have been investigated as possible vaccine antigens against NTHi infections. Previous investigations in our laboratory have shown that OMP26 from an NTHi 289 strain was able to significantly enhance pulmonary clearance of NTHi in a rat model in which animals were immunised via intestinal Peyer'

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44

Goddard, Elizabeth Anne. "IgG subclasses, specific antibodies and immunoglobulin allotypes in children with invasive Haemophilus influenzae type B and Staphylococcus aureus infections." Doctoral thesis, University of Cape Town, 1994. http://hdl.handle.net/11427/27003.

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OBJECTIVE: The principal objective of this study was to measure various aspects of immunity in children with invasive infections due to Haemophilus influenzae type b and Staphylococcus aureus. These serious infections are a significant cause of childhood morbidity and mortality in all populations and affect healthy as well as compromised children. Evidence suggests that imbalances or deficiencies in certain aspects of immunity such as IgG subclasses, the capacity to make specific subclass antibodies, antibody affinities, complement isotypes, immunoglobulin allotypes or mannose binding protein

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45

Tsai, Chen Hsuan Sherry. "The study of candidate sialometabolism genes and sialometabolism gene regulation in Haemophilus influenzae." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:656c6197-b37e-4fba-8544-fbcdd74b549d.

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Sialic acid (SA) is a known major virulence factor of Haemophilus influenza (Hi). This study aims to analyse the functions of some candidate sialometabolism genes, and to further our current understanding on the Hi sialometabolism gene regulation. Two candidate sialometabolism genes (HI0227 and HI0148) and their adjacent ORFs (HI0228, HI0148.1 and HI0149) were studied. HI0148.1 and HI0149 are transcribed as a single gene in screened NTHi strains, and we refer to the combined ORF as NTHI0236 (the designation in strain 86-028NP). Across Hi strains screened, the sequences of HI0227, HI0148 and NT

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46

Kodituwakku, Aruna Poojitha. "Antigen specific B cells in the immune response to Haemophilus influenzae type b PRP conjugate vaccine /." Title page, table of contents and summary only, 2004. http://web4.library.adelaide.edu.au/theses/09PH/09phk769.pdf.

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47

Hardison, Rachael Lake. "Haemophilus pathogenesis during otitis media: Influence of nutritional immunity on bacterial persistence and intracellular lifestyles." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1540483623343597.

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48

Abdalla, Hana Khidir. "Modulation of inflammatory mediators during experimental bacterial meningitis /." Linköping : Department of Molecular and Clinical Medicine, Linköping university, 2005. http://www.bibl.liu.se/liupubl/disp/disp2005/med907s.pdf.

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49

Kelle, Karine. "Un facteur de virulence potentiel chez Campylobacter Jejuni : la p95." Aix-Marseille 1, 1998. http://www.theses.fr/1998AIX11017.

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L'adhesion de la bacterie aux anterocytes represente une etape capitale dans l'infection a campylobacter jejuni. Les structures bacteriennes impliquees dans ce phenomene sont encore peu connues. Dans ce travail, la capacite a adherer de divers isolats cliniques de c. Jejuni a ete etudiee in vitro, sur des cellules caco-2 en culture. La difference de phenotype de deux souches a permis d'effectuer une approche genetique. A l'aide d'une sonde oligonucleotidique correspondant a la sequence consensus de divers facteurs d'adhesion, un gene de c. Jejuni 85h a ete clone et sequence. La sequence protei

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50

Quentin, Roland. "Caractérisation phénotypique et génotypique de souches de Haemophilus SP. Responsables des infections génitales et néonatales : implications physiopathologiques, épidémiologiques et taxonomiques des résultats." Paris 11, 1988. http://www.theses.fr/1988PA114828.

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