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1

Kumar Gopathoti, Kiran, and Naguri Divya Sruthi. "Implementation of low power N-bit hybrid parallel prefix adder using Xilinx-ISE." International Journal of Scientific Methods in Engineering and Management 01, no. 01 (2023): 36–46. http://dx.doi.org/10.58599/ijsmem.2023.1104.

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Recently, digital circuitry has demanded a decrease in space and power by decreasing time while simultaneously improving performance in speed. This has resulted in a need for more efficient use of the available space. Adders are fundamental components that are used in the construction of digital circuits. As a consequence of this, the performance of adders has to be improved in order to enhance the performance of integrated circuits that are used in the real world. The creation of a novel parallel prefix adder (PPA) architecture known as Hybrid PPA is the primary topic of this article. Hybrid
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Nalina, R., S. S. Ashwini, and M. Z. Kurian Dr. "Implementation of Unsigned Multiplier Using Area-Delay-Power Efficient Adder." International Journal for Research in Applied Science & Engineering Technology 3, no. 7 (2015): 429–32. https://doi.org/10.5281/zenodo.33100.

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Multiplication and addition are most widely and oftenly used arithmetic computations performed in all digital signal processing applications. Multiplication is the basic arithmetic operation which is present in many part of the digital computer especially in signal processing systems such as graphics and computation system. It requires substantially more hardware resources and processing time than addition and subtraction. In fact, 8.72% of all the instruction in typical processing units is multiplication. This paper deals with the basic multiplier that is shift and add multiplier. Accurate op
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Wang, Jian, Junqiang Sun, Qizhen Sun, Xinliang Zhang, and Dexiu Huang. "All-optical dual-direction half-subtracter based on sum-frequency generation." Optics Communications 281, no. 4 (2008): 788–92. http://dx.doi.org/10.1016/j.optcom.2007.10.061.

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4

Kamra, Kanwal, and K. Singh. "Photorefractive half-adder: beam-fanning for optical generation of ‘SUM’ and ‘CARRY’." Optics Communications 130, no. 4-6 (1996): 393–401. http://dx.doi.org/10.1016/0030-4018(96)82469-2.

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K, Ramya, Dr G. S. N. Raju, and Dr Sunny Dayal PA. "Array Design Using Genetic Algorithm for the Generation of Sum and Difference Patterns." International Journal of Electrical and Electronics Research 11, no. 1 (2023): 112–18. http://dx.doi.org/10.37391/ijeer.110115.

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In the field of pattern synthesis, the design of arrays to synthesis optimized sum and difference patterns in a successive manner is an important problem in most of the radars. Although several researchers published many papers in the open literature, investigations are made by the authors to design arrays of discrete radiators using a well-formulated Genetic Algorithm (GA). The practical constraints are taken into account to design an amplitude distribution to produce the sum pattern with desired side lobe levels without broadening the main beam. Such sum patterns are found to be very useful
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Stacey, T. W., and A. E. Middleditch. "The geometry of machining for computer-aided manufacture." Robotica 4, no. 2 (1986): 83–91. http://dx.doi.org/10.1017/s0263574700008547.

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SummaryA geometrical methodology for automatic machine tool command generation is introduced. The geometric entities relevant to machine tool operation are unambiguously defined by volume models. A vector sum operator is used to determine regions of the configuration space of the machine tool which correspond to undesired collisions, cavity access and material removal. Some indication of how cutter paths are generated is given and a practical implementation for the case of machining two and a half dimensional components under two and a half axis control is discussed in more detail.
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Ishibashi, Taka-Aki, and Hiroshi Onishi. "Multiplex Infrared-Visible Sum-Frequency Spectrometer with a Phase-Conjugated Pulse Mixing Device for Narrow-Bandwidth Visible Probe Generation." Applied Spectroscopy 56, no. 10 (2002): 1298–302. http://dx.doi.org/10.1366/000370202760355253.

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We have constructed a multiplex infrared-visible sum-frequency (SF) spectrometer. Picosecond narrow-bandwidth visible laser light (full width at half-maximum (FWHM) ∼8 cm−1, 400 nm) was obtained by sum-frequency mixing of a pair of phase-conjugated broad-bandwidth pulses generated from femtosecond laser light (∼110 fs, 800 nm). Femtosecond broad-band infrared laser light (FWHM ∼280 cm−1, 3.4 μm) was obtained as a difference frequency mixing output of the signal and idler lights of an optical parametric amplifier pumped by the femtosecond laser light. Broad-bandwidth sum-frequency signal light
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8

Epure, Manuela. "Foreword." Journal of Economic Development, Environment and People 7, no. 4 (2018): 4. http://dx.doi.org/10.26458/jedep.v7i4.604.

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Digital transformation, occurred in the past recent years, impacts many areas: from economics to society and reveal new opportunities, today when half of the world’s population is connected to the Internet but less than half trust that technology will make their lives better[1].“Over half of the global population is connected to the internet and has growing access to the sum total of human knowledge at their fingertips. The internet will increasingly bring about ever more transformational changes for human civilization. However, some of these changes will also bring unpredictable costs. We are
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Menezes, J. W. M., W. B. Fraga, A. C. Ferreira, et al. "All-Optical Half-Adder Using All-Optical XOR and AND Gates for Optical Generation of “Sum” and “Carry”." Fiber and Integrated Optics 29, no. 4 (2010): 254–71. http://dx.doi.org/10.1080/01468030.2010.485290.

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10

Kluth, Sebastian, and Martin Gasche. "Ersatzraten in der Gesetzlichen Rentenversicherung / Replacement Rates in the German Statutory Pension System." Jahrbücher für Nationalökonomie und Statistik 235, no. 6 (2015): 553–83. http://dx.doi.org/10.1515/jbnst-2015-0604.

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Summary This paper aims to find an adequate concept to evaluate the replacement rate of the latest retiree generation of 2010. Classic replacement rates fail to provide meaningful conclusions because they can only be calculated for around half the retirees. This paper proposes an alternative figure, the so-called life cycle replacement rate, which relates individuals’ pension payments to the average real income over their whole working history. In sum, work history related characteristics like marital status, income or retirement age strongly influence individuals’ replacement rates. Furthermo
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Sen, Sobhan. "“Half-hydration” at the air/water interface revealed by heterodyne-detected electronic sum frequency generation spectroscopy, polarization second harmonic generation, and molecular dynamics simulation." Journal of Chemical Physics 132, no. 14 (2010): 144701. http://dx.doi.org/10.1063/1.3372620.

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12

Schiefler, Nivaldo, Joaquim Maia, Fabio Schneider, Acácio Zimbico, Amauri Assef, and Eduardo Costa. "Generation and Analysis of Ultrasound Images Using Plane Wave and Sparse Arrays Techniques." Sensors 18, no. 11 (2018): 3660. http://dx.doi.org/10.3390/s18113660.

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Ultrasonic imaging is one of the most important techniques to help medical diagnosis. However, obtaining high quality images requires the acquisition, processing, and storage of a large amount of data. In this work, we evaluated a new ultrasound imaging technique based on plane wave and sparse arrays to increase the scan rate and reduce the amount of data amount to be stored. The performance of the proposed method was tested using simulated echo data (from Field II) and phantom data acquired using a Verasonics system equipped with a L11-4v linear array transducer. The tests were done using 128
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Chen, Jiayu, Zelai Xu, Yunfei Li, et al. "Accelerate Multi-Agent Reinforcement Learning in Zero-Sum Games with Subgame Curriculum Learning." Proceedings of the AAAI Conference on Artificial Intelligence 38, no. 10 (2024): 11320–28. http://dx.doi.org/10.1609/aaai.v38i10.29011.

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Learning Nash equilibrium (NE) in complex zero-sum games with multi-agent reinforcement learning (MARL) can be extremely computationally expensive. Curriculum learning is an effective way to accelerate learning, but an under-explored dimension for generating a curriculum is the difficulty-to-learn of the subgames –games induced by starting from a specific state. In this work, we present a novel subgame curriculum learning framework for zero-sum games. It adopts an adaptive initial state distribution by resetting agents to some previously visited states where they can quickly learn to improve p
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Nomikos, Nikolaos, Panagiotis Trakadas, Antonios Hatziefremidis, and Voliotis. "Full-Duplex NOMA Transmission with Single-Antenna Buffer-Aided Relays." Electronics 8, no. 12 (2019): 1482. http://dx.doi.org/10.3390/electronics8121482.

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The efficient deployment of fifth generation and beyond networks relies upon the seamless combination of recently introduced transmission techniques. Furthermore, as multiple network nodes exist in dense wireless topologies, low-complexity implementation should be promoted. In this work, several wireless communication techniques are considered for improving the sum-rate performance of cooperative relaying non-orthogonal multiple access (NOMA) networks. For this purpose, an opportunistic relay selection algorithm is developed, employing single-antenna relays to achieve full-duplex operation by
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Zhu, Yuhua, Guodong Qi, Yingmei Guo, and Dongmin Wang. "Analysis of Decorative Paintings in the Dragon and Tiger Hall of Yuzhen Palace: Culture, Materials, and Technology." Coatings 14, no. 8 (2024): 1022. http://dx.doi.org/10.3390/coatings14081022.

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Yuzhen Palace in Wudang Mountain, established in the 10th year of the Yongle reign of the Ming dynasty (1412 AD), is a significant heritage site within the ancient architectural complex of Wudang Mountain, recognized as a UNESCO World Heritage Site. Despite being entirely relocated, the original paintings on the wooden beams of the Dragon and Tiger Hall exhibit clear characteristics of early Ming dynasty style, potentially being the only surviving wooden painted structures from the Ming dynasty in Wudang Mountain. To protect these valuable cultural relics and provide accurate information regar
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Maiorano, Amanda M., Alula Assen, Piter Bijma, et al. "Improving accuracy of direct and maternal genetic effects in genomic evaluations using pooled boar semen: a simulation study1." Journal of Animal Science 97, no. 8 (2019): 3237–45. http://dx.doi.org/10.1093/jas/skz207.

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Abstract Pooling semen of multiple boars is commonly used in swine production systems. Compared with single boar systems, this technique changes family structure creating maternal half-sib families. The aim of this simulation study was to investigate how pooling semen affects the accuracy of estimating direct and maternal effects for individual piglet birth weight, in purebred pigs. Different scenarios of pooling semen were simulated by allowing the same female to mate from 1 to 6 boars, per insemination, whereas litter size was kept constant (N = 12). In each pooled boar scenario, genomic inf
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17

Sakakibara, Y., T. Furukawa, D. H. Singer, et al. "Sodium current in isolated human ventricular myocytes." American Journal of Physiology-Heart and Circulatory Physiology 265, no. 4 (1993): H1301—H1309. http://dx.doi.org/10.1152/ajpheart.1993.265.4.h1301.

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Although fast sodium current (INa) plays a major role in the generation and conduction of the cardiac impulse, the electrophysiological characteristics of INa in isolated human ventricular myocytes have not yet been fully described. We characterized the human ventricular INa of enzymatically isolated myocytes using whole cell voltage-clamp techniques. Sixty myocytes were isolated from ventricular specimens obtained from 22 patients undergoing open-heart surgery. A low temperature (17 degrees C) and Na+ concentration in the external solution (5 or 10 mM) allowed good voltage control and facilit
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18

Laß, K., H. W. Bange, and G. Friedrichs. "Seasonal signatures in SFG vibrational spectra of the sea surface nanolayer at Boknis Eck Time Series Station (SW Baltic Sea)." Biogeosciences 10, no. 8 (2013): 5325–34. http://dx.doi.org/10.5194/bg-10-5325-2013.

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Abstract. The very thin sea surface nanolayer on top of the sea surface microlayer, sometimes just one monomolecular layer thick, forms the interface between ocean and atmosphere. Due to the small dimension and tiny amount of substance, knowledge about the development of the layer in the course of the year is scarce. In this work, the sea surface nanolayer at Boknis Eck Time Series Station (BE), southwestern Baltic Sea, has been investigated over a period of three and a half years. Surface water samples were taken monthly by screen sampling and were analyzed in terms of organic content and com
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19

Laß, K., H. W. Bange, and G. Friedrichs. "Seasonal signatures in SFG vibrational spectra of the sea surface nanolayer at Boknis Eck Time Series Station (SW Baltic Sea)." Biogeosciences Discussions 10, no. 2 (2013): 3177–201. http://dx.doi.org/10.5194/bgd-10-3177-2013.

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Abstract. The very thin sea surface nanolayer on top of the sea surface microlayer, sometimes just one monomolecular layer thick, forms the interface between ocean and atmosphere. Due to the small dimension and tiny amount of substance, knowledge about the development of the layer in the course of the year is scarce. In this work, the sea surface nanolayer at Boknis Eck Time Series Station (BE), southwestern Baltic Sea, has been investigated over a period of three and a half years. Surface water samples were taken monthly by screen sampling and were analyzed in terms of organic content and com
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20

Ye, Ding-Wei, Jian Zhang, Hua Yang, et al. "Phase 1 dose escalation of SYS6002 (CRB-701), a next-generation nectin-4 targeting antibody drug conjugate (ADC)." Journal of Clinical Oncology 42, no. 4_suppl (2024): 622. http://dx.doi.org/10.1200/jco.2024.42.4_suppl.622.

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622 Background: Linker-conjugation of an ADC is a key feature in optimizing highly active and well tolerated agents. For maximal intra-tumoral delivery, linkers need to be highly stable in the systemic circulation yet allow for efficient drug release at the target site. SYS6002 (CRB-701) is a next generation Nectin-4 ADC that makes use of third-generation conjugation technology designed to overcome dose-limiting toxicities observed with the commonly approved linker-payload system involved in agents like enfortumab vedotin (EV). Non-clinically, SYS6002 demonstrates preferential internalization-me
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21

Khanh, Ngo Tan Vu, and Van Dinh Nguyen. "Max-Min Fairness and Sum Throughput Maximization for In-Band Full-Duplex IoT Networks: User Grouping, Bandwidth and Power Allocation." Electronics 9, no. 12 (2020): 2182. http://dx.doi.org/10.3390/electronics9122182.

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The skyrocketing growth in the number of Internet of Things (IoT) devices has posed a huge traffic demand for fifth-generation (5G) wireless networks and beyond. In-band full-duplex (IBFD), which is theoretically expected to double the spectral efficiency of a half-duplex wireless channel and connect more devices, has been considered as a promising technology in order to accelerate the development of IoT. In order to exploit the full potential of IBFD, the key challenge is how to handle network interference (including self-interference, co-channel interference, and multiuser interference) more
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22

Vikash, Pooniya, Pravin Kumar Mr., and Deepika Chauhan |. Md. Asif Iqbal Dr. "Hybrid Biomass Solar Power System with Establishment of Raw Material Procure." International Journal of Trend in Scientific Research and Development 2, no. 3 (2018): 830–34. https://doi.org/10.31142/ijtsrd11105.

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The utilization of sustainable power sources is ending up exceptionally essential because of the restricted stores of non renewable energy sources and worldwide ecological worries for the creation of electrical power age and usage. In remote regions, towns, it is anything but difficult to get more sum biomass. Subsequently by the utilization of crossover frameworks comprising of Biomass and PV for creation of electrical vitality in these remote regions can be more temperate. On the off chance that the advancement of a PC based approach for assessing, the general execution of independent half a
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Rand, MD, JB Lock, C. van't Veer, DP Gaffney, and KG Mann. "Blood clotting in minimally altered whole blood." Blood 88, no. 9 (1996): 3432–45. http://dx.doi.org/10.1182/blood.v88.9.3432.bloodjournal8893432.

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The sequences of events regulating thrombin generation during tissue factor-initiated clotting in whole blood at 37 degrees C in which the contact pathway was suppressed with corn trypsin inhibitor are studied using quantitative Western blotting of factor V, prothrombin, platelet factor 4, antithrombin III, and fibrinogen. In addition, fibrinopeptide A (FPA), thrombin-antithrombin III (TAT) complex formation, and prothrombin fragment 1.2 (F1.2) were measured via commercially available enzyme-linked immunosorbent assays (ELISAs). In a typical experiment initiated with 40 pmol/L recombinant tiss
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Becker, Jonas, Julia Fakhiri, and Dirk Grimm. "Fantastic AAV Gene Therapy Vectors and How to Find Them—Random Diversification, Rational Design and Machine Learning." Pathogens 11, no. 7 (2022): 756. http://dx.doi.org/10.3390/pathogens11070756.

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Parvoviruses are a diverse family of small, non-enveloped DNA viruses that infect a wide variety of species, tissues and cell types. For over half a century, their intriguing biology and pathophysiology has fueled intensive research aimed at dissecting the underlying viral and cellular mechanisms. Concurrently, their broad host specificity (tropism) has motivated efforts to develop parvoviruses as gene delivery vectors for human cancer or gene therapy applications. While the sum of preclinical and clinical data consistently demonstrates the great potential of these vectors, these findings also
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Chiputa, Masoto, Minglong Zhang, G. G. Md Nawaz Ali, et al. "Enhancing Handover for 5G mmWave Mobile Networks Using Jump Markov Linear System and Deep Reinforcement Learning." Sensors 22, no. 3 (2022): 746. http://dx.doi.org/10.3390/s22030746.

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The Fifth Generation (5G) mobile networks use millimeter waves (mmWaves) to offer gigabit data rates. However, unlike microwaves, mmWave links are prone to user and topographic dynamics. They easily get blocked and end up forming irregular cell patterns for 5G. This in turn causes too early, too late, or wrong handoffs (HOs). To mitigate HO challenges, sustain connectivity, and avert unnecessary HO, we propose an HO scheme based on a jump Markov linear system (JMLS) and deep reinforcement learning (DRL). JMLS is widely known to account for abrupt changes in system dynamics. DRL likewise emerge
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26

Ugarova, Svetlana V. "Special aspects of radish selection and its seed breeding in Siberia." Vegetable crops of Russia, no. 4 (September 7, 2019): 25–28. http://dx.doi.org/10.18619/2072-9146-2019-4-25-28.

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Relevance An adaptive approach to the selection of vegetable plants highlights Siberian region for the distinctness of the general climate manifestations. The region is characterized by the general aridity of spring and the first half of summer combined with the sharp fluctuations of temperature during the growing season, a short frost-free period. And there is a positive aspect of the Siberian climate – the high level of solar insolation contributes to the intensification of photosynthesis and hastens all growth processes, reducing the need for the sum of biological temperatures, on average,
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27

Margerin, Ludovic, Andres Bajaras, and Michel Campillo. "A scalar radiative transfer model including the coupling between surface and body waves." Geophysical Journal International 219, no. 2 (2019): 1092–108. http://dx.doi.org/10.1093/gji/ggz348.

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SUMMARY To describe the energy transport in the seismic coda, we introduce a system of radiative transfer equations for coupled surface and body waves in a scalar approximation. Our model is based on the Helmholtz equation in a half-space geometry with mixed boundary conditions. In this model, Green’s function can be represented as a sum of body waves and surface waves, which mimics the situation on Earth. In a first step, we study the single-scattering problem for point-like objects in the Born approximation. Using the assumption that the phase of body waves is randomized by surface reflectio
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28

Saito, Tatsuhiko, and Akemi Noda. "Strain energy released by earthquake faulting with random slip components." Geophysical Journal International 220, no. 3 (2019): 2009–20. http://dx.doi.org/10.1093/gji/ggz561.

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SUMMARY This study investigates the strain energy change caused by earthquake faulting. While conventional theories often assumed uniform stress change on the fault plane, this study supposed the slip fluctuation and non-uniform stress change on the fault. By using a stochastic modelling of the slip distribution, we represent the ensemble average of the strain energy change by using the power spectral density function of the slip fluctuation. This yields the following results. (1) When the initial stress is uniform and the earthquake contains a fluctuating slip distribution, the released strai
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29

Mohammed Sanusi, Sadiq, and Ahmad Muhammad Makarfi. "Assessment of rural households’ willingness to pay for healthcare insurance in Bauchi state of Nigeria." Ekonomika i Organizacja Logistyki 9, no. 1 (2024): 79–96. https://doi.org/10.22630/eiol.2024.9.1.5.

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Contrary to previous studies on agriculture, cross-disciplinary studies on the value of health risk reduction (VHRR), value of statistical life (VSL), and value of statistical case (VSC) are extremely uncommon in Nigeria and the study area specifically. In light of the lack of information, this study will likely use the VSL and VSC methodologies to address the “benefit transfer” on environmental health risk reduction linked to morbidity incidence within the agricultural sector. Consequently, this research aimed to determine rural households’ willingness to pay (WTP) for healthcare insurance in
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30

Mendonça, Carlos A. "The face‐current concept and its application to survey design in electrical exploration." GEOPHYSICS 68, no. 3 (2003): 900–910. http://dx.doi.org/10.1190/1.1581042.

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This paper presents a new method to identify the regions over a 3D geoelectrical structure that produce major contributions to the electrical potential established in response to a dc source at the ground surface. The measured potential is represented by a sum of a known primary potential (due to a homogeneous half space) plus an unknown potential caused by conductivity inhomogeneities. Because the primary potential is continuous everywhere, the interfaces with a conductivity contrast act as sources or sinks of currents in order to maintain the continuity of the current density related to the
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31

Sharifi, Nima. "Abstract IA004: Metabolic mechanisms of prostate cancer progression that feed nuclear receptors." Cancer Research 83, no. 11_Supplement (2023): IA004. http://dx.doi.org/10.1158/1538-7445.prca2023-ia004.

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Abstract The androgen axis is central to prostate cancer physiology and therapy. Androgens are gonadal and extragonadal in origin, both of which stimulate the androgen receptor (AR). The use of medical castration (ADT), adrenal androgen ablation (i.e., abiraterone) and potent AR antagonists (i.e., enzalutamide, apalutamide, darolutamide), has yielded complex clinical states of prostate cancer, including disease states that are resistant to multiple forms of hormonal therapy. One of the major questions that arises is whether men can be identified who will benefit from earlier intensive hormonal
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32

Nazha, Bassel, Sharon Wu, Jacqueline T. Brown, et al. "Comprehensive genomic profiling of penile squamous cell carcinoma and impact of HPV status on immune-checkpoint inhibition-related biomarkers." Journal of Clinical Oncology 40, no. 6_suppl (2022): 4. http://dx.doi.org/10.1200/jco.2022.40.6_suppl.004.

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4 Background: Penile squamous cell carcinoma (SCC) is a rare and aggressive malignancy with few treatments in the advanced setting and little success of immune-checkpoint inhibitions (ICI). Around half of penile SCC cases are linked to HPV infection. We aimed to report the landscape of somatic alterations and ICI-related biomarkers in penile SCC in the Caris Life Sciences dataset and to establish signatures for HPV-dependent and HPV-independent oncogenesis. Methods: Penile SCC tumors were analyzed using next-generation sequencing of DNA (TruSeq, 45 genes; NextSeq, 592 genes and NovaSeq, whole
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Chu, Victoria T., Katrina Kalantar, Eran Mick, et al. "Antimicrobial Resistance in the Upper Respiratory Tract of Children Compared with Adults." Journal of the Pediatric Infectious Diseases Society 12, Supplement_1 (2023): S2—S3. http://dx.doi.org/10.1093/jpids/piad070.005.

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Abstract Background Antimicrobial resistance (AMR) is a growing global public health threat. In 2019, resistant bacterial infections and respiratory tract infections were a leading cause of death in children worldwide. While the gut is a known reservoir of AMR genes, there is little data on the AMR burden in the respiratory tract. We used metagenomic RNA next-generation sequencing (mNGS) to describe bacterial AMR genes detected in the upper respiratory tract of children and compare with adults. Methods We leveraged two established cohort studies of children and adults diagnosed with acute resp
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34

Yassine, Farah, Mohamed A. Kharfan-Dabaja, Athanasios Tsalatsanis, et al. "Trends in Utilization of Stored Cryopreserved Autologous Peripheral Hematopoietic Cells (APBHC) Intended for a Second (or beyond) Autologous Hematopoietic Cell Transplantation (AHCT) in Patients with Multiple Myeloma (MM): A Single Center Experience." Blood 138, Supplement 1 (2021): 665. http://dx.doi.org/10.1182/blood-2021-152635.

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Abstract Background: AHCT is a standard of care treatment for eligible patients (pts) with MM. Most consensus guidelines recommend that at the time of first AHCT, enough APBHC should be collected to perform two AHCT. However, recent studies have shown that with each decade after 1990, the use of cryopreserved APBHC for a salvage AHCT has declined and is now in the range of 4.6-15% in the decade between 2010-2018. The collection and storage of APBHC for two AHCT incurs additional costs and a prior single center cost analysis revealed that having had collected for just one AHCT in a cohort of 72
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Vallikivi, Laur. "Soome-ugri misjon: Eesti kristlaste hõimutöö Venemaal." Eesti Rahva Muuseumi aastaraamat, no. 61 (October 11, 2018): 154–81. http://dx.doi.org/10.33302/ermar-2018-007.

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Faith-Based Finno-Ugric Outreach: Estonian Christian Missionaries among Kindred Peoples in Russia This article provides an initial overview of the role of Christianity in the Finno-Ugric movement and the instrumentalisation of Finno-Ugric identity. It analyses the mission activity conducted by Estonians (and Finns to some extent) among speakers of Finno-Ugric (Uralic) languages in Russia. Above all, the writings of missionaries are used as the source – primarily mission publications published in Estonia. The background is the author’s fieldwork conducted among Nenets reindeer herders, who have
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Li, Lingxiao, Praechompoo Pongtornpipat, Timothy Tiutan, et al. "Potent Efficacy of BCL2 Inhibition with ABT-199 in High-Risk Aggressive B-Lymphoma Models When Combined with Knockdown of MCL1." Blood 124, no. 21 (2014): 506. http://dx.doi.org/10.1182/blood.v124.21.506.506.

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Abstract Avoiding apoptosis is a hallmark of cancer. Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma and carries a poor prognosis in cases at high-risk of failing up-front R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone). Frequent expression of the anti-apoptotic protein BCL2 is well-described in DLBCL in numerous studies and is clear a negative prognostic marker when co-expressed with the oncogenic transcription factor c-MYC. Expression of the anti-apoptotic protein MCL1 also is found in about half of cases. BCL2 and MCL1 have redundant function
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Alden, Stephanie Leigh, Biagio Ricciuti, Giuseppe Lamberti, et al. "Changes in PD-L1 tumor proportion score are associated with CD274 gene (encoding PD-L1) copy number variation in non-small cell lung cancer." Journal of Clinical Oncology 39, no. 15_suppl (2021): 9029. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.9029.

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9029 Background: PD-L1 tumor proportion score (TPS) is often used to determine eligibility for first line therapy with immune checkpoint inhibitors (ICIs) in advanced non-small cell lung cancer (NSCLC). However, PD-L1 expression can vary over time and between tumor sites, potentially leading to inaccurate patient stratification. Therefore, it is critical to understand the clinicopathologic and genomic factors that are associated with PD-L1 changes in NSCLC. Methods: Clinicopathologic and genomic data were collected from patients with NSCLC and quantitative PD-L1 immunohistochemistry (IHC) on a
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ZHANG Ziqi, YAN Shuncheng, TAO Chenyu, YU Xuan, ZHANG Shaofeng, and MA Xinwen. "Investigating dissociation mechanism of ethane dication via three-body fragmentation." Acta Physica Sinica 74, no. 6 (2025): 0. https://doi.org/10.7498/aps.74.20250008.

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Molecular ions are widely distributed in the ionosphere of planetary atmospheres, and their fragmentations can generate different ions and neutral fragments. Studying the kinetic energy distribution and generation mechanism of the final products is helpful in understanding fundamental phenomena in astrophysics and plasma physics. In particular, ethane is an important molecule found in Titan and comet, its fragmentation may be involved in the generation of complex hydrocarbons, as well as the atmospheric escape processes on Titan.<br>In this paper, we carried out the experiment on ethane
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He, Jie, Shan Zhong, Michelle Nahas, et al. "Predictive and Prognostic Significance of Comprehensive Genomic Profiling in Patients with Diffuse Large B-Cell Lymphoma." Blood 126, no. 23 (2015): 2651. http://dx.doi.org/10.1182/blood.v126.23.2651.2651.

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Abstract Introductions: We assessed the benefit of adding comprehensive genomic profiling (CGP) to improve clinical outcomes in both first-line and relapse/refractory settings in adult patients with diffuse large B-cell lymphoma (DLBCL). Current standard first-line therapy affords long term remission in only 55-60% of patients, and less than half of these cases can be treated successfully following relapse. Thus, there is a clear unmet clinical need to improve the standard of care for all patients with DLBCL. We interrogated specimens from 125 patients with DLBCL using a novel next generation
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Arumov, Artavazd, Piumi Y. Liyanage, Asaad Trabolsi, et al. "R-Nanochop Incorporating a TFR1-Targeted Doxorubicin Nanocarrier Is Superior to R-CHOP in a PDX Model of Diffuse Large B-Cell Lymphoma." Blood 136, Supplement 1 (2020): 43. http://dx.doi.org/10.1182/blood-2020-133482.

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Diffuse large B-cell lymphoma (DLBCL) comprises a third of non-Hodgkin lymphoma (NHL), with incidence steadily rising in what is already the most common hematologic malignancy. The backbone of potentially curative frontline chemoimmunotherapy combinations like R-CHOP is doxorubicin (Dox), still considered the most active anti-lymphoma agent. Relapsed or refractory (rel/ref) disease after frontline treatment carries persistently poor prognosis, even with recent advances in immunotherapy. Development and implementation of new therapeutic strategies remain urgent priorities to address unmet clini
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Guerin, Annie, Cindy Revol, Agnihotram V. Ramanakumar, et al. "Twelve-Month Cost per Responder (CPR) Analysis of Nilotinib and Dasatinib As Front-Line Therapy in Patients with Philadelphia Chromosome-Positive (Ph+) Chronic Myeloid Leukemia in Chronic Phase (CML-CP)." Blood 124, no. 21 (2014): 1304. http://dx.doi.org/10.1182/blood.v124.21.1304.1304.

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Abstract Introduction: Nilotinib and dasatinib, two second-generation tyrosine kinase inhibitors (TKIs), have been associated with higher rates of molecular response compared to imatinib in the treatment of newly diagnosed CML-CP patients based on the ENESTnd and DASISION trials. A published indirect comparison study of efficacy outcomes between nilotinib and dasatinib showed that nilotinib had significantly higher rates of molecular response by 12 months compared to dasatinib: major molecular response (MMR; defined as BCR/ABL1 level ≤0.1% on International Scale [IS]): 56.1% vs. 45.9%; MR4.0 (
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Ferrer, Alejandro, Zachary D. Stephens, Susan M. Geyer, et al. "Distribution of Chromosome-Arm Specific Telomere Length in Patients with Telomere Biology Disorders." Blood 142, Supplement 1 (2023): 4103. http://dx.doi.org/10.1182/blood-2023-187486.

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Introduction: Telomere biology disorders (TBD) are multisystem diseases often associated with bone marrow failure (BMF) and pulmonary fibrosis. TBD are clinically diagnosed when mean telomere lengths (TL) in blood cells measured by clinical flowFISH assays fall <1 st percentile, in comparison to age-matched reference controls. This information has limitations, e.g. TL in blood cells may not represent TL in other organs (e.g. lung, liver) and moreover, individuals with high clinical suspicion of TBD can show borderline average TL which complicates their diagnosis. The likely reason for t
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Blätte, Tamara J., Laura K. Schmalbrock, Sabrina Skambraks, et al. "NGS-Based Monitoring of Measurable Residual Disease in FLT3-ITD Positive Acute Myeloid Leukemia." Blood 132, Supplement 1 (2018): 2778. http://dx.doi.org/10.1182/blood-2018-99-113382.

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Abstract Background: In acute myeloid leukemia (AML), most patients respond to chemotherapy initially, but the risk of relapse remains high. Continued monitoring of measurable residual disease (MRD) following therapy onset enables early assessment of treatment response and clinical intervention. However, while appropriate assays exist for several genetic markers, some of the most common aberrations in AML, FLT3 internal tandem duplications (FLT3-ITDs), have remained a challenging target due to insertion site and length heterogeneity. The established diagnostic assay based on PCR and fragment a
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Glierova, Hana, Martin Panigaj, Jana Semberova, et al. "Impairment of Erythropoiesis In Inbred Cellular Prion Protein Deficient Mice." Blood 116, no. 21 (2010): 2032. http://dx.doi.org/10.1182/blood.v116.21.2032.2032.

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Abstract Abstract 2032 Cellular prion protein (PrPc) plays a key role in pathogenesis of prion diseases, however, its physiologic function remains unclear. The involvement of PrPc in hematopoiesis was suggested by importance of its expression for self renewal and survival of long term repopulating hematopoietic stem cells. Prion diseases were shown to deregulate transcription of several erythroid genes and we have demonstrated reduction of erythroid cell and erythropoietin production in FVB PrP-/- (Zurich I) mice in response to acute anemia (Zivny J. et al. Blood Cells Mol Dis. 2008;40:302-307
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Pan, Darren, Tarek H. Mouhieddine, Weijia Fu, et al. "Outcomes after CAR T Cells in Multiple Myeloma Patients with Extramedullary and Paramedullary Disease." Blood 142, Supplement 1 (2023): 1006. http://dx.doi.org/10.1182/blood-2023-177749.

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Background: Extramedullary disease (EMD) is a poor prognostic factor for multiple myeloma patients even in the era of novel therapies, while patients with paramedullary disease (PMD) have historically fared better. We sought to characterize EMD and PMD in the peri-CAR T period, assess their effects on outcomes after CAR T, and evaluate the ability of CAR T-cell therapy to clear EMD. Methods: We retrospectively analyzed patients with relapsed/refractory multiple myeloma (RRMM) treated with CAR T-cell therapy in a clinical trial or with a commercially approved product at The Mount Sinai Hospital
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Bejar, Rafael, Elli Papaemmanuil, Torsten Haferlach, et al. "Somatic Mutations in MDS Patients Are Associated with Clinical Features and Predict Prognosis Independent of the IPSS-R: Analysis of Combined Datasets from the International Working Group for Prognosis in MDS-Molecular Committee." Blood 126, no. 23 (2015): 907. http://dx.doi.org/10.1182/blood.v126.23.907.907.

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Abstract Background Somatic mutations identified in patients with myelodysplastic syndromes (MDS) are associated with disease features and carry prognostic information independent of the International Prognostic Scoring System (IPSS) and the revised IPSS (IPSS-R). Risk models that include mutation information have been proposed, but not widely adopted. In practice, there is no consensus on how to best combine clinical information with tumor sequencing data to predict prognosis. To accomplish this, we must define the relevant genes to consider and accurately measure their prognostic impact. Her
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Закладной, Г. А., А. В. Яицких, and Д. С. Степаненко. "Distribution of uric acid in the grinding products of grain affected by rice weevil." Food processing industry, no. 3 (March 2, 2023): 79–81. http://dx.doi.org/10.52653/ppi.2023.3.3.016.

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Целью работы было изучить возможность снижения содержания мочевой кислоты в пищевых зерновых продуктах, полученных из пораженного насекомыми зерна. Для этого экспериментально исследовали распределение мочевой кислоты в продуктах помола зерна пшеницы и возможность оздоровления муки за счет удаления из конечного продукта наиболее загрязненных мочевой кислотой помольных фракций. Зерно влажностью около 14 % было заселено жуками рисового долгоносика Sitophilus oryzae из расчета 50 экз./кг и заложено на хранение при температуре 25 °С для образования зараженности в разных стадиях развития вредителя.
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Kuzmanovic, Teodora, Bhumika J. Patel, Jibran Durrani, et al. "ANKRD26 Coding Variants Presenting with Giant Platelets and a Predisposition to Myeloid Neoplasia." Blood 134, Supplement_1 (2019): 4233. http://dx.doi.org/10.1182/blood-2019-130520.

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Mutations (MT) in the 5' untranslated region (UTR) of ANKRD26 (A26) are implicated in ANKRD26- related thrombocytopenia (A26-RT), an autosomal dominant disorder of mild to moderate thrombocytopenia (TP) often presenting in adulthood, although severe and pediatric cases are reported. Erythrocyte and leukocyte counts are normal to increased, with unremarkable morphology. Platelet (plt) size is usually normal, as with ETV6- and RUNX1-mutated TP. Together, A26, ETV6, and RUNX1 germline (GL) MT comprise a separate 2016 WHO category of myeloid neoplasms (MN) with GL predisposition and preexisting pl
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Maksimovic, Ljubomir. "Thematic stratiotai in Byzantine society: A contribution to a new assessment of the subject." Zbornik radova Vizantoloskog instituta, no. 39 (2001): 25–49. http://dx.doi.org/10.2298/zrvi0239025m.

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Investigations of thematic organization never yielded generally accepted results. The reasons behind this are closely tied to limitations regarding source material. On the one hand, there are certain chronological or thematic units poorly represented in the sources. On the other, there are cases well documented by the sources which can, however, overlook data logically expected to be mentioned. Still, Byzantine sources, including legal texts with their often anachronous clauses, have an understanding of thematic priorities which differs from our own, defined by our contemporary standards. Scho
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Polupan, Yu P., Yu F. Melnyk, O. D. Biriukova, S. V. Pryima, and L. V. Mitioglo. "GROWTH, REPRODUCTIVE CAPACITY AND PRODUCTIVITY OF COWS OF DIFFERENT BREEDS, METHODS OF SELECTION AND PATERNAL ORIGIN." Animal Breeding and Genetics 63 (August 9, 2022): 91–119. http://dx.doi.org/10.31073/abg.63.09.

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The aim of the research. To conduct a comparative analysis of growth characteristics, productive qualities and reproductive capacity of dairy cows using purebred breeding and interbreeding in the herd.
 Маterials and methods of reserch. The study was conducted in the herd of the State Enterprise “Niva” on cows of Ukrainian Red- and Black-and-White dairy and Holstein breeds. The analysis included information on the growth intensity, reproductive capacity and milk productivity of 978 cows with the first calving during 2015-2021. Among the breeding herds of the Ukrainian Red-and-White and Bl
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