Academic literature on the topic 'Hallmark Art Collection'

George Herbert’s The Temple exemplifies the principles of Protestant meditation described by Joseph Hall in The Art of Divine Meditation (1606). Shaped by Catholic and Protestant traditions, Hall’s approach to meditation combines deliberate and extemporary reflection on natural and artificial objects. Like Hall, Herbert in The Temple practices the Augustinian habit of reading mundane signs as emblems with spiritual signification. More particularly Hallian are the stages—from the preparation of the subject for meditation through the dynamic concentration on the object of meditation to the transformation of the subject—that the reader of Herbert’s poems follows. Taken individually, in sets, and in the whole three-part collection, the sacred poems and private ejaculations of The Temple are spiritual exercises that bear the hallmarks of Anglican meditation.

Throughout the Mediterranean the study of the destruction, reuse, moving and preservation of statues has provided a window onto the transformation of Rome during a time of ascendant Christianity. The preservation of statuary collections is increasingly important in this regard. Archival research has revealed the discovery of one such collection at Ostia's Sanctuary of Magna Mater, a treasure trove of sculptures, reliefs and at least one bronze statue. All were well preserved, and several were found in the open spaces of the sanctuary. Together they span 500 years of history, stretching into the late fourth century. Unfortunately, the late antique significance of this group has never been acknowledged. This paper situates that collection within the social world of late antique Ostia, where many statues of both sacred and non-sacred subjects remained on display. The late fourth-century dedication, in particular, set alongside the earlier pieces, demonstrates that the ‘mood and motivations’ of traditional Roman religion, in Clifford Geertz's terms, also remained quite visible. The presence of this accumulated tradition, a hallmark of Rome's ‘civil religion’ for centuries, testifies to the high social status afforded one of Ostia's most historic sites, even during an increasingly Christian age.

Swan Point in central Alaska contains the oldest recognized human occupation in Alaska (Cultural Zone 4b [CZ4b]), dating to circa 14,000 cal BP. This component consists of a microblade and burin industry with clear technological ties to the Siberian Upper Paleolithic Diuktai Culture. Through the systematic use of the Yubetsu method for the production of microblades, Swan Point is technologically more similar to Siberian microblade sites than to later-age (Denali complex) microblade sites in Alaska. The Yubetsu method is the hallmark of the Diuktai Culture, and in Alaska, Swan Point CZ4b is the only component with systematic production of microblades using the Yubetsu method. Other late Pleistocene and Holocene microblade sites in Alaska have an industry based on Campus-style, conical, or tabular microblade cores. Analysis of the collection furthers our understanding of how CZ4b relates to previous Siberian Diuktai-related assemblages and to later Alaskan Denali-related sites. We interpret the CZ4b component as representing a brief single event that has major cultural and technological implications for the early colonization process of North America.

The accumulation of abnormal protein aggregates represents a universal hallmark of neurodegenerative diseases (NDDs). Post-translational modifications (PTMs) regulate protein structure and function. Dysregulated PTMs may influence the propensity for protein aggregation in NDD-proteinopathies. To investigate this, we systematically reviewed the literature to evaluate effects of PTMs on aggregation propensity for major proteins linked to the pathogenesis and/or progression of NDDs. A search of PubMed, MEDLINE, EMBASE, and Web of Science Core Collection was conducted to retrieve studies that investigated an association between PTMs and protein aggregation in seven NDDs: Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS), spinocerebellar ataxias, transmissible spongiform encephalopathy, and multiple sclerosis. Together, 1222 studies were identified, of which 69 met eligibility criteria. We identified that the following PTMs, in isolation or combination, potentially act as modulators of proteinopathy in NDDs: isoaspartate formation in Aβ, phosphorylation of Aβ or tau in AD; acetylation, 4-hydroxy-2-neonal modification, O-GlcNAcylation or phosphorylation of α-synuclein in PD; acetylation or phosphorylation of TAR DNA-binding protein-43 in ALS, and SUMOylation of superoxide dismutase-1 in ALS; and phosphorylation of huntingtin in HD. The potential pharmacological manipulation of these aggregation-modulating PTMs represents an as-yet untapped source of therapy to treat NDDs.

This is the second volume of a two-volume special issue of the American Indian Culture and Research Journal dedicated to the indirect impact of COVID-19 on Indigenous Peoples. The first, 44.2, reports on COVID-19’s extensive impact on Indigenous Peoples and the resulting variety of responses at community and local levels. This second volume, 44.3, provides specific research and insights for improving reporting, identification, and prevention of COVID-19 cases and deaths. Several contributors to this issue respond to the urgent need to ensure, for small populations, and Indigenous Peoples in particular, that data collection provides detailed information on race and tribal nation identifiers. Like this lack of data disaggregation, data inaccuracy also impedes understanding of the impact of a pandemic. Other researchers find that a hallmark of this pandemic—the shift from in-person to virtual interactions in many aspects of life—has clarified that innovative telehealth and virtual methods already underway for Indigenous Peoples may represent the frontiers of better health care, access, and service. “Moving Forward: No Scientific Integrity without an Acknowledgment of Past Wrongs,” a commentary emphasizing the necessary actions the US government must take if progress is to be made, concludes this special issue.

NH4+ transport by the distal nephron and NH4+ detoxification by the liver are critical for achieving regulation of acid-base balance and to avoid hyperammonemic hepatic encephalopathy, respectively. Therefore, it has been proposed that rhesus type B glycoprotein (Rhbg), a member of the Mep/Amt/Rh NH3 channel superfamily, may be involved in some forms of distal tubular acidosis and congenital hyperammonemia. We have tested this hypothesis by inactivating the RHbg gene in the mouse by insertional mutagenesis. Histochemical studies analyses confirmed that RHbg knockout (KO) mice did not express Rhbg protein. Under basal conditions, the KO mice did not exhibit encephalopathy and survived well. They did not exhibit hallmarks of distal tubular acidosis because neither acid-base status, serum potassium concentration, nor bone mineral density was altered by RHbg disruption. They did not have hyperammonemia or disturbed hepatic NH3 metabolism. Moreover, the KO mice adapted to a chronic acid-loading challenge by increasing urinary NH4+ excretion as well as their wild-type controls. Finally, transepithelial NH3 diffusive permeability, or NH3 and NH4+ entry across the basolateral membrane of cortical collecting duct cells, measured by in vitro microperfusion of collecting duct from KO and wild-type mice, was identical with no apparent effect of the absence of Rhbg protein. We conclude that Rhbg is not a critical determinant of NH4+ excretion by the kidney and of NH4+ detoxification by the liver in vivo.

Chronic infection of the cystic fibrosis (CF) airway by the opportunistic pathogen Pseudomonas aeruginosa is the leading cause of morbidity and mortality for adult CF patients. Prolonged infections are accompanied by adaptation of P. aeruginosa to the unique conditions of the CF lung environment, as well as marked diversification of the pathogen into phenotypically and genetically distinct strains that can coexist for years within a patient. Little is known, however, about the causes of this diversification and its impact on patient health. Here, we show experimentally that, consistent with ecological theory of diversification, the nutritional conditions of the CF airway can cause rapid and extensive diversification of P. aeruginosa. Mucin, the substance responsible for the increased viscosity associated with the thick mucus layer in the CF airway, had little impact on within-population diversification but did promote divergence among populations. Furthermore, in vitro evolution recapitulated traits thought to be hallmarks of chronic infection, including reduced motility and increased biofilm formation, and the range of phenotypes observed in a collection of clinical isolates. Our results suggest that nutritional complexity and reduced dispersal can drive evolutionary diversification of P. aeruginosa independent of other features of the CF lung such as an active immune system or the presence of competing microbial species. We suggest that diversification, by generating extensive phenotypic and genetic variation on which selection can act, may be a key first step in the development of chronic infections.

Abstract Background Social dysfunction is a hallmark characteristic of schizophrenia, and individuals with this disorder often report difficulty navigating daily social interactions. Perceptual deficits, such as faulty visual attention to important aspects of social stimuli (i.e., failing to look at the most relevant portions of a stimulus), may be one mechanism by which social deficits arise. Faulty modulation of specific neural regions such as the right temporoparietal junction (rTPJ), may underlie visual attention abnormalities, and may act as suitable targets for neurostimulation. The current study utilizes neurostimulation to experimentally manipulate specific neural networks and determine whether stimulation 1) improves visual attention, 2) improves performance on social cognitive tasks, and 3) whether altered visual attention moderates this improved performance. Methods Using a double-blind crossover design, participants underwent both active and sham stimulation via tDCS approximately one week apart. Half of the participants received active and sham stimulation of rTPJ (n = 22), while the other half received active and sham stimulation of a comparator site within the social brain network (dmPFC, n = 23). After stimulation, visual attention was assessed through concurrent eye-tracking while participants complete several tasks of social cognition (emotion recognition: ER40, BLERT; Theory of Mind: TASIT). Visual attention was determined as the proportion of time spent attending to socially and contextually important AOIs. Results Data collection and data processing are still ongoing for this study, however planned interim analyses on a subset of the total sample (n = 45) indicate small to medium effects of active stimulation to the rTPJ compared to sham and dmPFC stimulation for both visual attention (ηp2=.035) and social cognitive performance on the BLERT task (ηp2=.067), specifically. These same effects are not seen in the other social cognitive tasks. Final analyses based on a sample size of 72 individuals are expected to be complete prior to presentation at SIRS 2020. Discussion This study is the first, to our knowledge, to target this neural region within schizophrenia for the purposes of improving visual attention and, subsequently, social cognition. Should the pattern of results from our interim analyses hold after completion of data collection, results indicate that active stimulation to the rTPJ has a unique impact on dynamic emotional stimuli, improving visual attention and accuracy in emotion recognition, suggesting a primary role of the rTPJ and visual attention in performance on this task. The intricate design of this study allows for thorough investigation of potential mechanisms by which social cognitive deficits develop, and the use of novel experimental techniques align with the theme of this year’s conference.

Abstract Abstract 5028 Multiple myeloma (MM) is a hematological malignancy of the bone marrow caused by the dysregulated proliferation of monoclonal antibody producing plasma cells. A hallmark feature of cancer is the ability to evade cell death signals induced by stress response cues. The Bcl-2 family of proteins regulates the intrinsic apoptosis pathways and consists of pro-apoptotic (Bax, Bak, Bad, Bim, Noxa, Puma) and pro-survival (Bcl-2, Bcl-xL, Mcl-1); the balance of which dictates the life or death status of MM tumor cells. Thus, there is a strong rationale to target members of the Bcl-2 proteins for the treatment of MM. ABT-199 is a potent BH3-only mimetic that selectively antagonizes Bcl-2 and is currently in phase I clinical trials for the treatment of hematological malignancies. Therefore, we evaluated the efficacy of ABT-199 as a single agent and in combination with standard of care drugs such as Velcade (bortezomib) in preclinical models of MM. A panel of 21 human MM cell lines was evaluated in vitro for to sensitivity to ABT-199. ABT-199 potently inhibited cell viability in a sub-set of MM cell lines (7/21) with EC50 values less than 1 μM. Expression of Bcl-2, Bcl-xL, Mcl-1, Bim and other Bcl-2 family proteins were evaluated by protein and mRNA. Cell line modeling identified thresholds for expression of Bcl-2, Bcl-xL and Mcl-1 that best predicted sensitivity and resistance to ABT-199 and the dual Bcl-2/Bcl-xL antagonist, navitoclax. Consistent with the target inhibition profile of these drugs, we found that MM lines that were Bcl-2high/Bcl-xLlow/Mcl-1low are the most sensitive to ABT-199 treatment. Whereas cell lines that are Bcl-xLhigh remain sensitive to navitoclax but not ABT-199. MM cell lines that are Mcl-1high are less sensitive to both ABT-199 and navitoclax, suggesting that Mcl-1 is a resistance factor to both drugs. Utilizing a novel Mesoscale Discovery based immunoassay we determined that levels of Bcl-2/Bim complexes also correlated with sensitivity of ABT-199 in the MM cell lines tested. In addition, the t(11;14) status in these cell lines associated with sensitivity to ABT-199. The clinical relevance of the Bcl-2 pro-survival expression pattern in MM cell lines, was determined by a collection of bone marrow biopsies and aspirates (n=27) from MM patients by immunohistochemistry for prevalence of Bcl-2 and Bcl-xL. Similar to our in vitro observations, the majority (75%) of the MM bone marrow biopsies and aspirates had high Bcl-2 levels whereas 50% had high Bcl-xL expression. Therefore, a subset of patient samples (33%) were identified with a favorable biomarker profile (Bcl-2high/Bcl-xLlow) that may predict ABT-199 single agent activity. ABT-199 synergized with bortezomib in decreasing cell viability in the majority of MM cell lines tested in vitro based on the Bliss model of independence analyses (Bliss score range = 10 to 40). However the window of combination activity was reduced due to high degree of sensitivity to bortezomib alone. Therefore, the combination efficacy of ABT-199 and bortezomib was further evaluated in vivo in MM xenograft models that expressed high levels of Bcl-2 protein (OPM-2, KMS-11, RPMI-8226, H929 and MM. 1s). Bortezomib treatment alone at a maximum tolerated dose resulted in tumor regressions or stasis in all xenograft models tested. ABT-199 at a maximum tolerated dose was moderately efficacious (defined by tumor growth delay) as a single agent in xenograft models that expressed high protein levels of Bcl-2 but relatively lower levels of Bcl-xL. However, the combination of ABT-199 with bortezomib significantly increased the overall response rate and durability of anti-tumor activity when compared to bortezomib, resulting in increased cell death in vivo. Treatment with bortezomib increased levels of the pro-apoptotic BH3-only protein, Noxa, in MM xenograft models that expressed high levels of Mcl-1. Given that the induction of Noxa by bortezomib results in neutralization of Mcl-1 pro-survival activity in MM models [Gomez-Bougie et al; Cancer Res. 67:5418–24 (2007)], greater efficacy may be achieved when Bcl-2 is antagonized by ABT-199 thereby inhibiting pro-survival activity occurring through either Bcl-2 or Mcl-1 and increasing cell death. Thus, our preclinical data support the clinical evaluation of ABT-199 in combination with bortezomib in MM patients in which relative expression of the Bcl-2 pro-survival proteins may serve as predictive biomarkers of drug activity. Disclosures: Sampath: Genentech: Employment, Equity Ownership. Punnoose:Genentech: Employment, Equity Ownership. Boghaert:Abbott Pharmaceuticals: Employment, Equity Ownership. Belmont:Genentech: Employment, Equity Ownership. Chen:Abbott Pharmaceuticals: Employment, Equity Ownership. Peale:Genentech: Employment, Equity Ownership. Tan:Genentech: Employment, Equity Ownership. Darbonne:Genentech: Employment, Equity Ownership. Yue:Genentech: Employment, Equity Ownership. Oeh:Genentech: Employment, Equity Ownership. Lee:Genentech: Employment, Equity Ownership. Fairbrother:Genentech: Employment, Equity Ownership. Souers:Abbott Pharmaceuticals: Employment, Equity Ownership. Elmore:Abbott Pharmaceuticals: Employment, Equity Ownership. Leverson:Abbott Pharmaceuticals: Employment, Equity Ownership.

AbstractEffective data management is critical for quality research in any hematopoietic stem cell transplantation (HSCT) center for accuracy, reliability, and validity of the data. HSCT research is a dynamic and multi-domain process encompassing innovative therapeutic modalities, techniques, and interventions to change the existing standard of care and optimize survival outcomes and patients’ quality of life. Research has evolved as one of the core competencies for the standardization, accreditation, and academic standing of the transplant center. The Data Unit is the center of gravity and the hub of research (databases, registries, translational research, and randomized control trials) in a quality cancer care facility. HSCT data collection, collation, and interpretation have become an integral part of the treatment rather than an option. Quality assurance (QA) and continuous quality improvement (CQI) in data management are pivotal for credibility, measurable/quantifiable outcomes, clinically significant impact, and setting benchmarks. Quality assurance, ethical conduct, and monitoring of HSCT data are the hallmarks of a center of excellence in galvanizing the therapeutic interventions and optimizing the outcomes.

Coerced forgetting — forgetting as repressive erasure — has been a hallmark of many of the totalitarian regimes of the 20th century. However, the act of forgetting is not always negative. This chapter discusses three kinds of forgetting: prescriptive forgetting, or forgetting as an act of common good; forgetting as constitutive of the formation of a new identity; and forgetting as annulment, a response to a surfeit of information. Far from representing failures, all of these processes may play significant roles in the establishment and enhancement of social bonds.

This chapter provides an institutional history of the Organization of Black American Culture (OBAC), one of the most renowned African American artist collectives of the Black Arts movement. It recounts OBAC’s efforts to challenge Chicago’s established racial order and to reorient Black Chicago’s relationship to artistic production. It argues that OBAC pioneered several community-centered projects that served as hallmark modes of artistic practice within the movement while simultaneously helping to popularize the era’s burgeoning ideas. The group made Chicago an important epicenter of movement activity, attracting artists, activists, and intellectuals from around the world. At their peak, OBAC sparked a national intellectual debate over their creative philosophy of “a black aesthetic,” effectively polarizing arts discourse as it related to African Americans. Their growing popularity and heightened national profile generated a number of internal challenges, including intractable ideological and class contradictions, and tensions between individual professional aspirations and collective community engagement.

This chapter examines how, in Ulysses' Gaze, Theo Angelopoulos strives to combine history, myth, and politics in ways that constitute a cinema of historical experience, collective memory, and ethics. Angelopoulos' films have been praised for their historical ambition, political themes and explorations of memory, as well as for their commitment to cinematic modernism. For some critics, like David Bordwell, Angelopoulos is a late modernist auteur whose ‘anachronistic’ cinematic style bears the hallmarks of 1960s and 1970s ‘political modernism’. For others, like Fredric Jameson, Angelopoulos' work is best understood as hybrid or transitional. The chapter considers how Angelopoulos' aesthetic style expresses historical experience and cultural memory and argues that Angelopoulos' methods as a filmmaker are paradigmatically modernist.

Governments have turned to the use of information and communication technologies with the aim of improving service delivery, encouraging citizens in the decision making process, and enhancing accountability, transparency, and effectiveness. Effective inclusive participation of citizens in the government of their country requires access to information through modern technologies. Access to information is vital for transparency, accountability, participation, and the rule of law – all hallmarks of democratic governance. This chapter looks at the role of librarians and records managers in promoting e-government. Their traditional role of collecting, organizing, preserving, and disseminating information places them in a very significant position in e-governance implementation. However, in an electronic environment, they face a number of challenges which include economic, technological, and information literacy. The role played by these professionals, and the challenges each meet are discussed. Some recommendations are provided to enhance the role of these professionals in e-government implementation.

Governments have turned to the use of information and communication technologies with the aim of improving service delivery, encouraging citizens in the decision making process, and enhancing accountability, transparency, and effectiveness. Effective inclusive participation of citizens in the government of their country requires access to information through modern technologies. Access to information is vital for transparency, accountability, participation, and the rule of law – all hallmarks of democratic governance. This chapter looks at the role of librarians and records managers in promoting e-government. Their traditional role of collecting, organizing, preserving, and disseminating information places them in a very significant position in e-governance implementation. However, in an electronic environment, they face a number of challenges which include economic, technological, and information literacy. The role played by these professionals, and the challenges each meet are discussed. Some recommendations are provided to enhance the role of these professionals in e-government implementation.