Academic literature on the topic 'Hand, Thomas G'

Abstract The title page of the 1594 Quarto text of Dido, Queen of Carthage assigns the play to two authors: Christopher Marlowe and Thomas Nashe. Some scholars, such as J. P. Collier, F. G. Fleay, Alexander Grosart, Tucker Brooke, and Thomas Merriam, have argued that Marlowe and Nashe co-authored the play, or that Nashe added significant material to Marlowe’s text. This article assesses the internal evidence for Nashe’s hand in the play by examining its prosody, vocabulary, phraseology, rhyming habits, and stage directions in comparison to works ascribed to Nashe and Marlowe. The article also explores different modes of collaboration, such as the possibility that Nashe helped to plot, revise, or edit the play.

This book attempts to integrate symbolic processing, in the form of minimalism, with connectionism. Minimalism represents sentences as symbolic structures resulting from a formal process of syntactic derivation. Connectionism, on the other hand, represents sentences as patterns of association between linguistic features. These patterns are said to obey statistical regularities of linguistic usage instead of formal linguistic rules. The authors of the book argue that human sentence processing displays both structural and statistical characteristics and therefore requires the integration of the two views.

Nine new species of eriophyoid mites from the Hengduan Mountains, southwestern China are described and illustrated. They are Cosella delavayi sp. nov. on Castanopsis delavayi Franch. (Fagaceae); Tegonotus fabris sp. nov. on Abies fabri (Mast.) Craib (Pinaceae); Phyllocoptruta hodginsii sp. nov. on Fokienia hodginsii (Dunn) Henry et Thomas (Cupressaceae); Calvittacus mollissimus sp. nov. on Castanea mollissima (Fagaceae); Anthocoptes artemisia sp. nov. on Artemisia sp. (Asteraceae); Tetraspinus fabaceae sp. nov. on Cajanus cajan (L.) Mill sp. (Fabaceae); Neorhynacus molle sp. nov. on Rhododendron molle (Blume) G. Don (Ericaceae); Rhyncaphytoptus dielsianus sp. nov. on Trema dielsiana Hand.-Mzt (Ulmaceae) and Konola mollissima sp. nov. on Castanea mollissima (Fagaceae). All these new eriophyoid mite species are vagrants causing no apparent damage to their host plants.

Abstract With characteristic candour, David Hume is prepared to admit that in ordinary life, but certainly not when reflecting on the nature of perceptual experience, he has no option but to ‘believe in the existence of body’ despite his philosophical reasonings to the contrary. In this instance, his commitment to ‘Common Sense’ has become, as it was not to become for his contemporary Thomas Reid, a direct consequence of participating in a day-to-day existence if nevertheless one which he has no option but to reject when reflecting in the study. Ludwig Wittgenstein, on the other hand, presents us with a picture of what has come to be regarded as a form of Humean ‘phenomenalist language’, private in nature, which, in one of the most famous passages of his later philosophy, he appears to reject via a form of reductio ad absurdum argument. In what follows, it will be questioned whether his ‘argument’ clearly represents phenomenalist proposals which Hume’s successors, e. g., A.J. Ayer, accepted without question. If there is a misunderstanding here on both sides, an investigation into its nature must lead to an appreciation of the varying roles attributed by these philosophers to the notion of ‘Common Sense’.

Abstract The paper questions the postmodern, wide-spread tendency to abusively reconstruct the meaning of some texts of the philosophers of the past, so that they may serve as allies or foes in our own contemporary ideological wars. The chosen example is an article by Umberto Eco, called “Anti-Porphyry”, and the parallel chapter, “Dictionary vs. Encyclopedia”, from his well-known book Semiotics and the Philosophy of Language. According to Eco, the famous “Porphyry’s tree” is the pictorial representation of the so-called “strong thought”, which — so he believes — was being subverted from the outset in the benefit of the “weak thought” or “Encyclopedia thought” even in the works of some essentialist philosophers like Aristotle or St. Thomas Aquinas. On the other hand, Eco thinks he found in d’Alembert’s Discours préliminaire to the French Encyclopédie a forerunner of postmodern “weak thought”, which resembles the so-called 3rd type labyrinth or the “rhizome” described by G. Deleuze, and which is the opposite of the logic encapsulated in the “Porphyry tree”. The paper attempts to show that Eco distorted the ideas of the above-mentioned philosophers by dislodging them from their original metaphysical context and by manipulating some of the relevant texts. So, in Eco’s view, both Aquinas and d’Alembert anachronistically became forerunners of postmodernism. In fact, what Eco eventually got was less an accurate description of some philosophies of the past, than a historical-philosophical reconstruction rather abusively legitimizing his own ideas.

Abstract Introduction Guduchi (Tinospora cordifolia (Willd.) Miers ex Hook.f. and Thomas) and Yashtimadhu (Glycyrrhiza glabra Linn.) are the medicinal plants traditionally used for various properties such as rasayana, ayushprada, vayah-sthapana, cakshuya, varnya, keshya, vatapittajit, raktaprasadana, varnahar, shothhar, vishghan, and chhardighan in Ayurveda. Modern studies also have explicitly revealed a wide range of pharmacological effects of both drugs such as antioxidant, immunomodulator, brain tonic and memory enhancer, gastroprotective, anti-inflammatory, antiulcer and wound healing, and antibacterial properties. On the other hand, cancer and various side effects of its treatment with chemotherapy/radiotherapy have emerged as a major public health concern all over the world including India. Aim The main objective of this study was to observe the clinical efficacy of guduchi and yashtimadhu against the adverse effects of chemotherapy. Study Design A clinical research, prospective in style, wherein a hypothesis was based on previous study on the various effects of T. cordifolia and G. glabra, was made to assess its effects on side effects of chemotherapy in cancer patient. Materials and Methods Randomly selected (n = 38) cancer patients, receiving chemotherapy and divided into four groups as A, B, C, D, were administered trial drugs as 1 g guduchi ghan tablet to group B, 1 g yashtimadhu ghan wati to group C and 1 g of guduchi and yashtimadhu ghan tablet both were given to group D thrice a day with water for 90 days. Group A was control group and no drug was given. A follow-up was done on every 15 days for 3 months. Clinical assessment of the study was based on before therapy ( BT) and after therapy (AT) effects of guduchi yashtimadhu in all adjuvant groups on the parameters namely subjective parameters, that is, side effects of chemotherapy and objective on hemoglobin (Hb) gm%, total leucocytes count (TLC), platelet count (PC), B. urea and S. creatinine level. For statistical analysis in both parameters paired t-test was used, and for comparison between all groups ANOVA test was used with corresponding p-values. Results The overall outcome shows, except alopecia (khalitya) in all other adverse symptoms of chemotherapy, p-value was either <0.05 or <0.001 that was considered to be highly significant. Guduchi and yashtimadhu were used as combined adjuvant therapy in group D, and the result was highly significant. In objective parameters, the outcome of p-values (i.e., p ≤ 0.05–0.01) showed the effects of guduchi yashtimadhu on Hb, TLC, PC, which was found to be significant. Conclusion The findings suggest that that there is a marked difference between BT and AT effect of guduchi yashtimadhu on the symptoms of chemotherapy and on Hb, TLC, PC level. Integration of Ayurveda in all adjuvant therapy groups showed significant results at 1% level of significance, against the side effects of chemotherapy in cancer patients.

Background:The semi-quantitative Outcome Measures in Rheumatology (OMERACT) Psoriatic Arthritis Magnetic Resonance Imaging Score (PsAMRIS) was developed for the evaluation of inflammatory and destructive changes in PsA,1 but has limited trial usage.Objectives:To retrospectively utilise the PsAMRIS in a multi-dose, randomised Phase IIb study of abatacept in patients with PsA who have inadequate response to DMARDs (NCT00534313).2Methods:Patients were randomised to abatacept (3, 10 or 30/10 mg/kg [the 30-mg/kg group switched to 10 mg/kg after the first two doses]) or placebo and treated for 169 days, after which all patients received abatacept 10 mg/kg through to Day 365. MRI scans of one hand or foot from 123 patients with PsA collected at baseline and on Days 85, 169 and 365 were centrally evaluated by two readers blinded to chronological order and treatment arm. Synovitis, bone oedema, tenosynovitis, periarticular inflammation, bone erosion, bone proliferation and joint space narrowing were assessed as per OMERACT PsAMRIS; a novel total inflammation score was calculated from the sum of synovitis, bone oedema, tenosynovitis and periarticular inflammation. Variables were analysed using all cases (hand or foot) and by hand and foot cases separately.Results:At Day 169, the abatacept 30/10 mg/kg or 10 mg/kg group showed the most decrease (improvement) in each inflammatory assessment (Figure 1). The Day 169 change from baseline severity in synovitis and tenosynovitis in the abatacept 30/10 mg/kg and 10 mg/kg groups, respectively, were significantly reduced (improved) compared with placebo (estimated differences of –0.966 [p=0.039] and –1.652 [p=0.014], respectively) (Table 1). Patients originally randomised to placebo and then switched to abatacept 10 mg/kg at Day 169 showed significant improvements in synovitis, tenosynovitis and total inflammation from Day 169 to Day 365 (Table 1, Figure 1). The structural outcomes joint space narrowing and bone erosion remained stable within each treatment group, showing little change from baseline to Days 85, 169 and 365. After separating hand and foot analyses (72 hand and 51 foot cases), only hand tenosynovitis in the 10-mg/kg group and foot synovitis in the 3-mg/kg group were significantly reduced (improved) at Day 169 compared with placebo (differences of –2.331 [p=0.017] and –1.689 [p=0.010], respectively). In general, more comparisons in the hand analysis were statistically significant versus in the foot analysis.Conclusion:This analysis confirmed the efficacy of abatacept 10 and 30/10 mg/kg when assessed with the OMERACT PsAMRIS. The inflammatory pathologies, synovitis and tenosynovitis, appeared to be the most responsive MRI outcomes. Analysing hand and foot cases together yielded results consistent with the primary clinical efficacy endpoint (ACR20 response rate), as the abatacept 10- and 30/10-mg/kg groups showed significant differences versus placebo at Day 169;2 reduced sample size in separate hand and foot assessments may have prevented finding significant results corresponding to the combined analysis. These results also demonstrate the responsiveness of the PsAMRIS in PsA randomised clinical trials.References:[1]Glinatsi D, et al. J Rheumatol 2015;42:2473–2479.[2]Mease P, et al. Arthritis Rheum 2011;63:939–948.Table 1.MRI variables showing significant treatment effectsaBetween groups at Day 169MRI scoreComparatorComparatorDifferenceSEp valueSynovitisPlaceboAbatacept 30/10 mg/kg–0.9660.4610.039TenosynovitisPlaceboAbatacept 10 mg/kg–1.6520.6620.014Placebo group before/after switchbMRI scoreTreatment, Day 169Treatment, Day 365DifferenceSEp valueSynovitisPlaceboAbatacept 10 mg/kg–1.0180.4580.029TenosynovitisPlaceboAbatacept 10 mg/kg–0.9400.3900.018Total inflammationPlaceboAbatacept 10 mg/kg–2.2751.0670.036aBased on change from baseline at the stated time points (unadjusted p values).bPatients were switched to abatacept 10 mg/kg after Day 169.Acknowledgements:Professional medical writing and editorial assistance was provided by Rob Coover, MPH, at Caudex and was funded by Bristol Myers Squibb.Disclosure of Interests:Mikkel Østergaard Speakers bureau: AbbVie, Celgene, Eli Lilly, Janssen, Novartis, Pfizer, Roche, Sanofi, UCB, Consultant of: AbbVie, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, Eli Lilly, Hospira, Janssen, Merck, Novartis, Novo, Orion, Pfizer, Regeneron, Roche, Sandoz, Sanofi, UCB, Grant/research support from: AbbVie, Bristol Myers Squibb, Celgene, Merck, Novartis, Paul Bird Speakers bureau: AbbVie, Bristol Myers Squibb, Eli Lilly, Novartis, Pfizer, UCB, Grant/research support from: Gilead, Chahin Pachai Shareholder of: Bristol Myers Squibb, Employee of: Bristol Myers Squibb, Shuyan Du Shareholder of: Bristol Myers Squibb, Employee of: Bristol Myers Squibb, Chun Wu Employee of: Bristol Myers Squibb, Jessica Landis Shareholder of: Bristol Myers Squibb, Employee of: Bristol Myers Squibb, Thomas Fuerst Employee of: Bioclinica, Inc., a contract research service providing radiology central reading services to pharmaceutical, biotech and medical device companies, Harris A Ahmad Employee of: Bristol Myers Squibb, Sean Connolly Shareholder of: Bristol Myers Squibb, Employee of: Bristol Myers Squibb, Philip G Conaghan Speakers bureau: AbbVie, Novartis, Consultant of: AstraZeneca, Bristol Myers Squibb, Eli Lilly, EMD Serono, Flexion Therapeutics, Galapagos, Gilead, Novartis, Pfizer.

There is limited understanding of which factors most influence take-up of DRR behaviour in the general population. This evidence gap may limit the effectiveness of DRR implementation and, hence, impede translation of increasing evidence for DRR1 into real-world public health benefits.Reviews of quantitative studies have identified poor knowledge and persistence of myths about ageing2,3 as important. However, these findings are limited by the scope of included questionnaires.Qualitative literature reporting the perspectives of the general public offers an opportunity to increase this understanding. Qualitative studies can examine poorly understood phenomena in greater depth and with fewer a priori assumptions. Qualitative evidence synthesis (QES) is increasingly recognised as valuable, particularly in relation to complex interventions like DRR.We will present a QES regarding the perspectives of dementia- free members of the general public towards DRR. Searches indicate that no QES for this topic currently exists.Systematic searches of Medline, PsycINFO, Embase and CINAHL for studies published since 1995 that have used qualitative methods to explore DRR perspectives in the general public were undertaken, supplemented by hand searches of included studies’ reference lists. Following independent screening by two reviewers, 41 publications based on 37 individual studies meeting inclusion criteria have been identified.Data will be analysed using thematic synthesis, as outlined by Thomas and Harden (2008)4 and recommended for QES regarding complex health interventions5. ‘Line-by-line’ inductive coding and development of descriptive themes across studies will produce a summary of the perspectives of the general public for DRR. A conceptual framework explaining the relationships between key themes and considering the implications for implementation will be proposed.The Critical Appraisal Skills Programme (CASP) tool will be used to appraise included studies. Rather than imposing an arbitrary quality cut-off point for inclusion, sensitivity analyses will be used to examine the influence of lower quality studies on review findings. Finally, the Confidence in the Evidence from Qualitative Reviews (CERQual) approach will facilitate assessment of confidence in review findings to aid future use. Data extraction is ongoing.Findings from this synthesis will support better targeted quantitative examination of DRR implementation determinants and more strategic intervention design. 1.World Health Organisation. Risk reduction of cognitive decline and dementia: WHO guidelines. World Health Organisation. 2019. Geneva. Licence CC BY-NC-SA 3.0 IGO2.Cahill, S., Pierce, M., Werner, P., Darley, A., Bobersky, A. A systematic review of the public’s knowledge and understanding of Alzheimer’s disease and dementia. Alz Dis Assoc Disord. 2015; 29:255-2753.Cations, M., Radisic, G., Crotty, M., Laver, K.E. What does the general public understand about prevention and treatment of dementia? A systematic review of population-based surveys. PLoS One. 2018, 13(4):e01960854.Thomas, J. and Harden, A. (2008). Methods for the thematic synthesis of qualitative research in systematic reviews, BMC Medical Research Methodology. 2008 July; 8:45. doi 10.1186/1471-2288-8-455.Noyes, J., Booth, A., Cargo, M., et al. (2018). Cochrane Qualitative and Implementation Methods Group guidance series – paper 1: introduction. J of Clin Epidemiol. 2018; 97:35-38

The present article is devoted to the general characteristics of the historical process of the formation of the sonata for the trombone (or with the participation of the trombone) in the European music of the Renaissance – Early Classicism era. A particular attention in the research has been paid to the study of the national stylistic, which was the main driving force in the evolution of the trombone at the level of the chamber instrumental and concert genres. It has been noted that since the time of A. Willaert and A. and J. Gabrieli brothers, the trombone and trombone consorts have been the permanent components of the concerts da chiesa, and later – da camera. Due to its construction and melodic-declamatory nature of the sounding, the trombone was in good agreement with both the voices of the choir and other instruments. Gradually, along with collective (concert) varieties of trombone sonatas, solo sonatas with bass began to appear, and they reflected the practice of the Baroque-era concert style. The article reviews a number of trombone sonatas of the Italian, Czech, Austro-German schools, which later became the model for composers of the Newest Time, who fully revealed the possibilities of the trombone semantics and techniques in the sonata genre. The article has noted that the formation of the instrumental sonata in Europe was associated with the practice of concerts in the church, which was for a long time practically the only place where academic music could be performed. The term “sonata” was understood then as the music intended for the instrumental performance, which, however, was closely connected with the vocal one. Therefore, the first samples of sonatas with the participation of the trombone were mixed vocal-instrumental compositions created by the representatives of the Venetian school of the second half of the 16th century – A. Willaert and A. and J. Gabrieli brothers. It has been noted that the key and largely “landmark” composition opening the chronicle of a concert sonata with the participation of trombones was the sonata called “Piano e forte” (1597), where the functions of trombone voices are already beginning to the counterpoint independence, rather than to duplicating the vocal ones. G. Gabrieli is the creator of one of the most large-scale, this time exclusively trombone compositions – “Canzon Quarti Toni” for 12 trombones, cornet and violin – one of the first trombone ensembles based on the genre of canzone as the progenitor of all the baroque instrumental-concert forms. It has been emphasized that among Italian masters of the subsequent period (the early Baroque), the trombone received a great attention from C. Monteverdi, who in his concert opuses used it as the substitute for viola da brazzo (three pieces from the collection called “Vespro della Beata Vergine”). It is noted that in the era of the instrumental versioning, when compositions were performed by virtually any instrumental compound, the trombone was already distinguished as an obligate instrument capable of competing with the cello. Sonata in D minor Op. 5 No. 8 by A. Corelli is considered a model of such a “double” purpose. It has been proved that the Italian schools of the 16th – 17th centuries, which played the leading role in the development of the sonata and concert instrumentalism, mainly the stringed and brass one and the brass one as well, were complemented by the German and Austrian ones. Among the masters of the latter one can distinguish the figure of G. Sch&#252;tz, who created “Fili mi, Absalon” for the trombone quartet and basso-continuo, where trombones are interpreted as instruments of cantilena sounding, which for a long time determines their use in opera and symphonic music, not to mention the sonata genre (introductions and slow parts). Along with the chamber sonata, which was written in the Italian style, German and Austrian masters of the 17th century turn to “tower music” (Tower music), creating their own opuses with almost obligatory participation of one or several trombones. Among such compositions there are the collection by G. Reich called “Quatricinua” of 24 tower sonatas (1696) for the cornet and three trombones, where, modelled on A. Corelli’s string-and-bow sonatas, the plays of a homophonic and polyphonic content are combined. The article notes that the creation of a solo sonata with bass for the trombone was historically associated with the Czech composing school of the second half of the 17th century. The first sample of such composition is the Sonata for the trombone and the thorough-bass (1669), written by a certain monk from the monastery of St. Thomas in Bohemia, where the instrument is shown in a wide range of its expressive possibilities. A significant contribution to the development of a trombone sonata was made by the Czech composer of the late 17th century P. Y. Veyvanovsky, who created a number of sonatas, which, despite the typical for that time performing versioning (trombone or viola da brazzo), were a milestone in the development of the genre in question. The traditions of the trombone sonata-quality genre in its three main expressions – da chiesa, da camera, “tower music” – have been preserved for a certain time in the era of Classicism. This is evidenced, for example, by F. Schneider’s 12 “Tower sonatas” for 2 pipes and 3 trombones (1803–1804). In general, in the classic-romantic era in the evolution of the trombone sonata genre there is a “pause”, which refers to both its collective and solo varieties. The true flourishing of the trombone sonata appeared only in the Newest time (from the end of the 19th century), when the instrumental music of a concert-chamber type declared itself not only as the one demanded by the public, but also as the leading, “title” field of creativity of a number of the leading composers. Among the instruments involved in the framework of the “new chamber-ness” (B. Asafiev) was also the trombone, one of the recognized “soloists” and “ensemblers” of the music from the past eras. The conclusions of the article note that the path travelled by the sonata for the trombone (or with the participation of the trombone) shows, on the one hand, the movement of the instrument to the solo quality and autonomy within the framework of “little-ensemble” chamber-ness (the sonata duet or the solo sonata without any accompaniment), on the other hand, the sustainable preservation of the ensemble origins of this genre (the trombone ensemble, sometimes in combination with other representatives of the brass group).

This handbook aims to provide an overview of knowledge about age and ageing in ‘Western’ societies at the beginning of the 21st century, which is intended to be equally suitable for research and practice. It focuses on relevant contributions from the social and behavioural sciences and their access to selected aspects of age and ageing. Its main topics can be described as quintessential core subjects, e.g. theories of ageing, socio-economic situation and inequalities, mental and physical health, social networks and social participation. These are supplemented by contributions on often marginalised topics and ‘emerging topics’ such as very old age, experiences of violence and delinquency, sexuality, and the spirituality and ethics of ageing. Finally, a series of topics relevant to everyday life and research practice (e.g. age and technology and data collection among the elderly) form a third central component of the book. With contributions by Heike Baranzke | Hermann Brandenburg | Susanne Brose | Josef Ehmer | Yvonne Eisenmann | Lea Ellwardt | Marcel Erlinghagen | Uwe Fachinger | Luise Geithner | Thomas Görgen | Bernadette Groebe | Helen Güther | Hans Gutzmann | Karsten Hank | Peter Häussermann | Rolf G. Heinze | Kira Hower | Anna Janhsen | Roman Kaspar | Daniela Klaus | Lars-Oliver Klotz | Franziska Kunz | Lisa Luft | Katharina Mahne | Michael Neise | Frank Oswald | Johannes Pantel | Susanne Penger | Holger Pfaff | M. Christina Polidori | Christian Rietz | Charlotte Şahin | Anna Schlomann | Holger Schmidt | Laura Schmidt | Wiebke Schmitz | Katrin Schneiders | Frank Schulz-Nieswandt | Andreas Simm | Julia Simonson | Anja Steinbach | Stephanie Stock | Julia Strupp | Clemens Tesch-Römer | Claudia Vogel | Raymond Voltz | Michael Wagner | Hans-Werner Wahl | Inka Wilhelm | Christiane Woopen | Susanne Zank

This chapter explores fugal writing in the genre that contemporary writers indicated was the “home” of fugue: the motet. Beginning with the establishment by Jean Mouton and others of the classic Renaissance motet—based on serious counterpoint within a point-of-imitation structure—in the first two decades of the century, the fugal motet received its most important features at the hands of Nicolas Gombert in the 1530s when he expanded the use of imitation beyond a single thematic statement in each voice to feature a texture based on multiple returning statements. This approach then formed the basis for motet writing by Thomas Crecquillon and Jacobus Clemens non Papa around mid-century and later by Francesco Guerrero and G. P. da Palestrina. By century’s end, composers had grown weary of fugue’s use in vocal music, such that it plays a lesser role in the motets of Lassus, but English composers contributed their own efforts in the 1580s and 1590s.

This chapter discusses the development of tort law in the second half of the nineteenth century. Tort law experienced its biggest growth spurt in the late nineteenth century. The legal world began to sit up and pay attention. The very first English-language treatise on torts appeared in 1859: Francis Hilliard’s book, The Law of Torts, Or Private Wrongs. Then came Charles G. Addison, Wrongs and Their Remedies in 1860, in England. By 1900, there was an immense literature on the law of torts; Joel Bishop and Thomas M. Cooley had written imposing treatises on the subject; the case law had swollen to heroic proportions. Tort law was a product of the industrial revolution; England here had a head start; problems emerged there first, and so did their tentative legal solutions.

In the last decade, the historicism that had become so familiar to us by the turn of the century has increasingly come under challenge, revised, reconsidered and often rejected from a number of different directions. This chapter explores recent innovations in and challenges to understanding the relationship between text and context, including the new formalism, historical phenomenology, and cognitive poetics. Of particular interest here are the innovations and difficulties that can come with attempting an historicism grounded in local affects and perceptions, with examples drawn from Thomas Browne and W. G. Sebald, among others. In the process, D’Addario considers the appeal of alternative literary histories, the difficulties of periodisation, and the legacies of New Historicism. The chapter ends with a gesture to embracing studies that admit their speculative nature, that embrace and accept their historicism as novel re-imaginings of the past.

In this study, immobilization process of the three (3) powder CFAs was studied. The major results on immobilization process were briefly presented. A total number of fifteen (15) column studies from the combination of the five (5) types of CFAs beads and the three (3) PMEs samples were performed. In each column study, a set of aggregate parameters of flow rate, empty bed contract time, operational time, and throughput volume was studied, and the data was fitted to existing modeling of breakthrough curves. The overall operational time was 12–24-hour, color removal efficiencies were 40–90%, and throughput volume of treated PMEs was 10–14 bed volume. For the column study, the correlation coefficient R2 value for each combination indicated that the Thomas model had a better fit with the observed data than the Adams-Bohart model, and the color adsorption capacities of CFA beads varied in a wide range of 0.31–28.23 mg/g.

Autochthony is fundamental to ancient Greek notions of belonging to the land. While the motif had a negligible presence in the literature of European Christendom, it returns with some force in modern productions by Stéphane Mallarmé, Thomas Hardy, D. H. Lawrence, E. M. Forster, and James Joyce. Martin Heidegger too draws on pre-Socratic Greek thought on the theme of autochthony. But there is a parallel tradition of belonging to the land that begins in the Pentateuch. In Exodus, God speaks to Moses about a Promised Land. In medieval Europe, Meister Eckhart reads Exodus as providing a special, mystical understanding of God’s soul, one that intertwines promised land with the human soul’s creative capacities, and lays the foundation for theologically infused politics in the German tradition. In Alexander Baumgarten, Immanuel Kant, and J. G. Fichte, nationalism is linked to Eckhart. In the twentieth century, Heidegger phenomenologically reinscribes earth, divinities, and dwelling poetically.

When, in 1978, the poet, critic, and editor Geoffrey Grigson (1905–85) was asked by the Times Literary Supplement which journals had influenced him when young, he answered that one magazine, Antiquity, founded and edited then by O. G. S. Crawford, still seems to me to have been the flower of all periodicals familiar to me in my day. In that treasury, so decently laid out (and so well printed . . . ), prehistory, and history, rather as it was understood by Marc Bloch in France, and later by W. G. Hoskins, and imagination, received a stimulus such as no periodical administered to literature. Antiquity was begun in 1927 by the field archaeologist O. G. S. Crawford (1886–1957) as a quarterly review aiming to disseminate the findings of a new generation of archaeologists in an accessible style and a visually attractive format. For Grigson, this journal most fitted the bill, in the late 1920s and 1930s, of what he calls the ‘periodical of Utopia’ that Tolstoy had called for in 1858. Tolstoy wanted a journal proclaiming the ‘independence and eternity of art’, where art would be saved from the politics that was engulfing nineteenth-century Russia, threatening to destroy or defile art. Such a journal was Grigson’s ideal, too. Drawing an implicit parallel between Tolstoy’s Moscow of 1858 and politicized interwar Britain, he decried the endemic admixture of politics with art in the periodical press at this time, when every ‘shrewd editor’ had an ‘axe to grind’. One of his favourites, the New Republic, while excellent, ‘came under the curse . . . which ordains that most literary journalism in our language must be for ever mixed with politics’. T. S. Eliot’s journal The Criterion was tainted by the same ‘curse’: ‘covert politics’, claimed Grigson, ‘slightly defiled its superiority’. Only in Antiquity, it seems, could Grigson discern art—‘independent and eternal’—without the defiling politics or the dullness that accompanied it in other journals and weeklies. Only in a publication that did not claim to deal with art could he find what he was looking for, as he viewed this archaeological journal through the lens of poetry. Antiquity, he wrote, made ‘all the past with firework colours burn’—a line he borrowed from Wyndham Lewis’s poem about Sir Thomas Browne’s antiquarian tract Urne Buriall.

Birthday symposia inevitably provide an opportunity for reflection. Noting that greater minds than mine have offered an apology for their life (St. Augustine, 1853 edition; St. Thomas Aquinas; John Henry cardinal Newman, 1864), I shall attempt to answer the question: What have been the lasting contributions of my generation - the generation that began its work before Richard Ernst’s epoch making development of 2D NMR, and the equally momentous development of high field spectrometers, pioneered by Harry Weaver at Varian, Rex Richards at Oxford and Gunther Laukien at Bruker, revolutionized the technology and put biological applications within everyone’s reach? I offer these insights in the spirit that to fully understand a subject one must understand its history. The essence of scientific endeavor is to see something no one has seen before - or understand something no one had understood before. If there had been such a contribution, it was to understand what biological questions could be asked by NMR and to develop prototype experiments showing how. Difficult as it is to imagine this today when such understanding is taken for granted, the now obvious just wasn’t obvious then. Quite the contrary: well considered expert opinion of the day held the undertaking to be of very dubious merit. Linus Pauling, with whom it was my great fortune to spend my postdoctoral year, was never much interested in nuclear magnetic resonance (and did not think much of its promise for biological applications, as he clearly pointed out at this symposium). But, Linus Pauling firmly believed in giving the young the freedom to explore, and so the first crude interpretation of a protein NMR spectrum, taken a few weeks earlier by Martin Saunders, Arnold Wishnia and J. G. Kirkwoodat Yale, was based on the first amino acid and peptide spectra we had taken at Caltech. When I got my first faculty job at Harvard, and wanted to apply for an NMR spectrometer, it was not quite as easy.

Thomas R. Hoye of the University of Minnesota devised (Nature 2013, 501, 531) the reagent 2, that cyclized to a benzyne that in turn dehydrogenated the alkane 1 to the alkene 3, and 4. Abigail G. Doyle of Princeton University developed (J. Am. Chem. Soc. 2013, 135, 12990) a reagent combination for the allylic fluorination of a terminal alkene 5 to the branched product 6. Yan Zhang and Jianbo Wang of Peking University oxidized (Angew. Chem. Int. Ed. 2013, 52, 10573) the methyl group of 7 to give the nitrile 8. Hanmin Huang of the Lanzhou Institute of Chemical Physics found (Org. Lett. 2013, 15, 3370) conditions for the carbonylation of the benzylic site of 9, leading to coupling with 10 to form the amide 11. Yu Rao of Tsinghua University effected (Angew. Chem. Int. Ed. 2013, 52, 13606) the direct methoxylation of 12, to give 13. Pd-mediated methoxylation had previously been described (Chem. Sci. 2013, 4, 4187) by Bing-Feng Shi of Zhejiang University. M. Christina White of the University of Illinois, Urbana found (J. Am. Chem. Soc. 2013, 135, 14052) that with variant ligands on the Fe catalyst, the oxidation of 14 could be directed selectively to either 15 or 16. C–H bonds can also be converted to C–N bonds. Sukbok Chang of KAIST oxi­dized (J. Am. Chem. Soc. 2013, 135, 12861) the unsaturated ester 17 with 18 to form the enamide 18. Gong Chen of Pennsylvania State University cyclized (Angew. Chem. Int. Ed. 2013, 52, 11124) the amide 20 to the γ-lactam 21. Professor Shi reported (Angew. Chem. Int. Ed. 2013, 52, 13588) a related approach to β-lactams. Ethers are easily oxidized. Taking advantage of this, Yun Liang of Hunan Normal University coupled (Synthesis 2013, 45, 3137) the bromoalkyne 23 with tetrahydro­furan 22 to give 24. Guangbin Dong of the University of Texas, Austin devised (J. Am. Chem. Soc. 2013, 135, 17747) a protocol for the β-arylation of ketones, includ­ing the preparation of 27 by the coupling of 25 with 26.

In this study, drop size, velocity, and volume flux for sprays produced by a pharmaceutical nozzle (Spraying Systems 1/4-JAU-SUE15A-PA67288–45°-SS) were characterized using a Fiber-PDA system (Dantec). Spraying was performed in a 120 cm (24 in) diameter tablet pan-coater (Accela-Cota Model 10, Thomas Engineering, UK). The separate influences of drum rotational speed and drying air flow rate were studied by making measurements at four different pan-coater operating conditions: stationary drum with drying air turned on/off, and 8 rpm rotating drum with drying air turned on/off. For each case, four different spraying conditions (liquid supply rate and atomizing air pressure) were used. PDA scans were performed along the spray semi-major and semi-minor axes at two different axial distances (7.5 and 10 cm) from the atomizer tip. Results were as follows. When both the drying air and drum rotation were absent, increasing liquid supply rate while operating the atomizer at the lower of two atomizing air pressures decreased drop size. The opposite occurred when operating at the higher of the two atomizing air pressures. This suggests that the nozzle operated as a simplex pressure-swirl atomizer at lower levels of atomizing air pressure, but as an air-assist atomizer at higher levels of atomizing air pressure. Regardless, liquid supply rate had no significant effect on drop velocity. In contrast, a decrease in atomizing air pressure or an increase in axial distance always led to an increase in drop size and a decrease in drop velocity. Supplying drying air to the pan-coater resulted in up to a 6 m/s increase in drop velocity, but had mixed effects on drop size. When the spray gun was operated as an air assist atomizer, supplying drying air to the drum led to an increase in D32. The reverse was observed when the gun operated as a simplex pressure-swirl atomizer. These two observations are most evident when operating at the lower liquid supply rate (70 g/min), suggesting that they may have arisen from drop evaporation. Increasing the drying air supply rate also reduced spray extent and volume flux magnitude. Adding drum rotation to the process generally led to (i) increased drop size and (ii) increased drop velocity. (i) likely arose from the transport of small drops away from the spray zone, while (ii) likely resulted from changes in droplet trajectories. Both are the result of the gas-phase swirling motion that is due to the drum rotation. (i) was most noticeable when the nozzle was operated as an air-assist atomizer. In addition, drum rotation decreased spray volume flux magnitude at the spray center, but increased it at other locations, essentially making the spray more dumbbell-shaped. Finally, the influence of drum rotation on drop velocity diminished when drying air flow was included. This was because the drying air momentum helped the drops oppose the effects of the swirling flow induced by the drum rotations.