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Journal articles on the topic 'Haplotype blocks'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 February 2022

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1

Weitzman, Jonathan B. "Haplotype blocks." Genome Biology 3 (2002): spotlight—20020524–01. http://dx.doi.org/10.1186/gb-spotlight-20020524-01.

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2

Chen, Wen-Pei, Che-Lun Hung, and Yaw-Ling Lin. "Efficient Haplotype Block Partitioning and Tag SNP Selection Algorithms under Various Constraints." BioMed Research International 2013 (2013): 1–13. http://dx.doi.org/10.1155/2013/984014.

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Patterns of linkage disequilibrium plays a central role in genome-wide association studies aimed at identifying genetic variation responsible for common human diseases. These patterns in human chromosomes show a block-like structure, and regions of high linkage disequilibrium are called haplotype blocks. A small subset of SNPs, called tag SNPs, is sufficient to capture the haplotype patterns in each haplotype block. Previously developed algorithms completely partition a haplotype sample into blocks while attempting to minimize the number of tag SNPs. However, when resource limitations prevent

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3

Salem, M. M. I., G. Thompson, S. Chen, A. Beja-Pereira, and J. Carvalheira. "Linkage disequilibrium and haplotype block structure in Portuguese Holstein cattle." Czech Journal of Animal Science 63, No. 2 (2018): 61–69. http://dx.doi.org/10.17221/56/2017-cjas.

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The objectives of this study were to estimate linkage disequilibrium (LD), describe and scan a haplotype block for the presence of genes that may affect milk production traits in Portuguese Holstein cattle. Totally 526 animals were genotyped using the Illumina BovineSNP50 BeadChip, which contained a total of 52 890 single nucleotide polymorphisms (SNPs). The final set of markers remaining after considering quality control standards consisted of 37 031 SNPs located on 29 autosomes. The LD parameters historical recombinations through allelic association (D') and squared correlation coefficient b

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4

Knürr, Timo, Ismo Strandén, Minna Koivula, Gert Pedersen Aamand, and Esa A. Mäntysaari. "Haplotype-assisted genomic evaluations in Nordic Red Dairy Cattle." Suomen Maataloustieteellisen Seuran Tiedote, no. 30 (January 31, 2014): 1–6. http://dx.doi.org/10.33354/smst.75280.

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In admixed populations originating from different base breeds, such as the Nordic Red Dairy Cattle, identity by state of haplotypes instead of single nucleotide polymorphisms (SNP) is a better surrogate for identity by descent. Therefore, haplotypes are expected to be more useful in recovering genetic relationships among animals and linkage disequilibrium between markers and quantitative trait loci (QTL). The objective of this study was to improve the prediction accuracy in genomic evaluations by the use of haplotypes of short chromosomal segments. In the first step, around 38,000 SNPs from a

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Sehgal, D., and S. Dreisigacker. "Haplotypes-based genetic analysis: benefits and challenges." Vavilov Journal of Genetics and Breeding 23, no. 7 (2019): 803–8. http://dx.doi.org/10.18699/vj19.37-o.

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The increasing availability of Single Nucleotide Polymorphisms (SNPs) discovered by Next Generation Sequencing will enable a range of new genetic analyses in crops, which was not possible before. Concomitantly, researchers will face the challenge of handling large data sets at the whole-genome level. By grouping thousands of SNPs into a few hundred haplotype blocks, complexity of the data can be reduced with fewer statistical tests and a lower probability of spurious associations. Owing to the strong genome structure present in breeding lines of most crops, the deployment of haplotypes could b

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6

ESKIN, ELEAZAR, ERAN HALPERIN, and RICHARD M. KARP. "EFFICIENT RECONSTRUCTION OF HAPLOTYPE STRUCTURE VIA PERFECT PHYLOGENY." Journal of Bioinformatics and Computational Biology 01, no. 01 (2003): 1–20. http://dx.doi.org/10.1142/s0219720003000174.

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Each person's genome contains two copies of each chromosome, one inherited from the father and the other from the mother. A person's genotype specifies the pair of bases at each site, but does not specify which base occurs on which chromosome. The sequence of each chromosome separately is called a haplotype. The determination of the haplotypes within a population is essential for understanding genetic variation and the inheritance of complex diseases. The haplotype mapping project, a successor to the human genome project, seeks to determine the common haplotypes in the human population. Since

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7

YUAN, AO, GUANJIE CHEN, CHARLES ROTIMI, and GEORGE E. BONNEY. "A STATISTICAL FRAMEWORK FOR HAPLOTYPE BLOCK INFERENCE." Journal of Bioinformatics and Computational Biology 03, no. 05 (2005): 1021–38. http://dx.doi.org/10.1142/s021972000500151x.

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The existence of haplotype blocks transmitted from parents to offspring has been suggested recently. This has created an interest in the inference of the block structure and length. The motivation is that haplotype blocks that are characterized well will make it relatively easier to quickly map all the genes carrying human diseases. To study the inference of haplotype block systematically, we propose a statistical framework. In this framework, the optimal haplotype block partitioning is formulated as the problem of statistical model selection; missing data can be handled in a standard statisti

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8

Karkar, Slim, Claire Dandine-Roulland, Jean-François Mangin, et al. "Genome-wide haplotype association study in imaging genetics using whole-brain sulcal openings of 16,304 UK Biobank subjects." European Journal of Human Genetics 29, no. 9 (2021): 1424–37. http://dx.doi.org/10.1038/s41431-021-00827-8.

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AbstractNeuroimaging-genetics cohorts gather two types of data: brain imaging and genetic data. They allow the discovery of associations between genetic variants and brain imaging features. They are invaluable resources to study the influence of genetics and environment in the brain features variance observed in normal and pathological populations. This study presents a genome-wide haplotype analysis for 123 brain sulcus opening value (a measure of sulcal width) across the whole brain that include 16,304 subjects from UK Biobank. Using genetic maps, we defined 119,548 blocks of low recombinati

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9

Kirby, D. A., and W. Stephan. "Haplotype test reveals departure from neutrality in a segment of the white gene of Drosophila melanogaster." Genetics 141, no. 4 (1995): 1483–90. http://dx.doi.org/10.1093/genetics/141.4.1483.

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Abstract Restriction map studies previously revealed extensive linkage disequilibria in the transcriptional unit of the white locus in natural Drosophila melanogaster populations. To understand the causes of these disequilibria, we sequenced a 4722-bp region of the white gene from 15 lines of D. melanogaster and 1 line of Drosophila simulans. Statistical tests applied to the entire 4722-bp region do not reject neutrality. In contrast, a test for high-frequency haplotypes ("Haplotype test") revealed an 834-bp segment, encompassing the 3' end of intron 1 to the 3' end of intron 2, in which the s

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10

Williams, Lucia, and Brendan Mumey. "Maximal Perfect Haplotype Blocks with Wildcards." iScience 23, no. 6 (2020): 101149. http://dx.doi.org/10.1016/j.isci.2020.101149.

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11

Bernig, Toralf, Willemijn Breunis, Nannette Brouwer, Dirk Roos, Taco W. Kuijpers, and Stephen J. Chanock. "Functional Consequences of Genetic Variation across the Entire MBL2 Locus: Possible Identification of 3′ SNPs That Could Modify Circulating Levels of MBL." Blood 104, no. 11 (2004): 1330. http://dx.doi.org/10.1182/blood.v104.11.1330.1330.

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Abstract Mannose-binding protein (MBL) is a critical component of innate immunity and provides first-line protection against pathogens by binding to N-acetyl-glucosamine and mannose residues on the surface of microorganisms (bacteria, fungi and parasites). MBL can activate complement by the lectin pathway. Both circulating MBL serum levels and functional activity have been correlated with common genetic variants in the MBL2 gene; decreased levels and activity correlate with 3 nonsynonymous single nucleotide polymorphisms, SNPs, (known as B, C and D) in exon 1 and two linked promoter SNPs (−550

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12

Srivastava, Swati, Krishnamoorthy Srikanth, Sohyoung Won, et al. "Haplotype-Based Genome-Wide Association Study and Identification of Candidate Genes Associated with Carcass Traits in Hanwoo Cattle." Genes 11, no. 5 (2020): 551. http://dx.doi.org/10.3390/genes11050551.

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Hanwoo, is the most popular native beef cattle in South Korea. Due to its extensive popularity, research is ongoing to enhance its carcass quality and marbling traits. In this study we conducted a haplotype-based genome-wide association study (GWAS) by constructing haplotype blocks by three methods: number of single nucleotide polymorphisms (SNPs) in a haplotype block (nsnp), length of genomic region in kb (Len) and linkage disequilibrium (LD). Significant haplotype blocks and genes associated with them were identified for carcass traits such as BFT (back fat thickness), EMA (eye Muscle area),

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13

Keam, B., H. Kim, S. Im, et al. "Comprehensive analysis of ERCC, XPD, and XRCC polymorphisms: Association with clinical outcomes in patients with advanced gastric cancer." Journal of Clinical Oncology 25, no. 18_suppl (2007): 4649. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.4649.

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4649 Background: Platinum-DNA adducts are repaired by nucleotide excision repair (NER) pathway, in which genes of the excision repair cross-complementation 1 (ERCC1), xeroderma pigmentosum group D (XPD) and X-ray repair cross-complementing group (XRCC) have an important role. The purpose of this study was to investigate the relationship between single nucleotide polymorphisms (SNPs) of these genes and the clinical outcomes to combination chemotherapy of 5-FU and oxaliplatin in advanced gastric cancer (AGC). Methods: We searched SNPs of NER pathway genes from database of the International Hapma

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14

Posada, D., and C. Wiuf. "Simulating haplotype blocks in the human genome." Bioinformatics 19, no. 2 (2003): 289–90. http://dx.doi.org/10.1093/bioinformatics/19.2.289.

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15

Franssen, Susanne U., Nicholas H. Barton, and Christian Schlötterer. "Reconstruction of Haplotype-Blocks Selected during Experimental Evolution." Molecular Biology and Evolution 34, no. 1 (2016): 174–84. http://dx.doi.org/10.1093/molbev/msw210.

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16

Bajgain, Prabin, and James A. Anderson. "Multi-Allelic Haplotype-Based Association Analysis Identifies Genomic Regions Controlling Domestication Traits in Intermediate Wheatgrass." Agriculture 11, no. 7 (2021): 667. http://dx.doi.org/10.3390/agriculture11070667.

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Intermediate wheatgrass (IWG) is a perennial forage grass undergoing a rigorous domestication as a grain crop. As a young grain crop, several agronomic and domestication traits need improvement for IWG to be relevant in current agricultural landscapes. This study genetically maps six domestication traits in the fourth cycle IWG breeding population at the University of Minnesota: height, seed length, seed width, shattering, threshability, and seed mass. A weak population structure was observed and linkage disequilibrium (r2) declined rapidly: 0.23 mega base pairs at conventional r2 value of 0.2

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17

LI, JING, and TAO JIANG. "EFFICIENT INFERENCE OF HAPLOTYPES FROM GENOTYPES ON A PEDIGREE." Journal of Bioinformatics and Computational Biology 01, no. 01 (2003): 41–69. http://dx.doi.org/10.1142/s0219720003000204.

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We study haplotype reconstruction under the Mendelian law of inheritance and the minimum recombination principle on pedigree data. We prove that the problem of finding a minimum-recombinant haplotype configuration (MRHC) is in general NP-hard. This is the first complexity result concerning the problem to our knowledge. An iterative algorithm based on blocks of consecutive resolved marker loci (called block-extension) is proposed. It is very efficient and can be used for large pedigrees with a large number of markers, especially for those data sets requiring few recombinants (or recombination e

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18

Gimeno, Lourdes, Helios Martínez-Banaclocha, M. Bernardo, et al. "NKG2D Polymorphism in Melanoma Patients from Southeastern Spain." Cancers 11, no. 4 (2019): 438. http://dx.doi.org/10.3390/cancers11040438.

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Background: Natural killer (NK) and CD8+ T cells are involved in the immune response against melanoma. C-Type lectin-like NK cell receptors are located in the Natural Killer Complex (NKC) region 12p13.2-p12.3 and play a critical role in regulating the activity of NK and CD8+ T cells. An association between polymorphisms in the NKC region, including the NKG2D gene and NKG2A promoter, and the risk of cancer has been previously described. The aim of this study was to analyze the association of polymorphisms in the NKC region with cutaneous melanoma in patients from southeastern Spain. Methods: Se

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19

Sallam, Ahmad H., Emily Conley, Dzianis Prakapenka, Yang Da, and James A. Anderson. "Improving Prediction Accuracy Using Multi-allelic Haplotype Prediction and Training Population Optimization in Wheat." G3: Genes|Genomes|Genetics 10, no. 7 (2020): 2265–73. http://dx.doi.org/10.1534/g3.120.401165.

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The use of haplotypes may improve the accuracy of genomic prediction over single SNPs because haplotypes can better capture linkage disequilibrium and genomic similarity in different lines and may capture local high-order allelic interactions. Additionally, prediction accuracy could be improved by portraying population structure in the calibration set. A set of 383 advanced lines and cultivars that represent the diversity of the University of Minnesota wheat breeding program was phenotyped for yield, test weight, and protein content and genotyped using the Illumina 90K SNP Assay. Population st

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20

SABAA, HADI, ZHIPENG CAI, YINING WANG, RANDY GOEBEL, STEPHEN MOORE, and GUOHUI LIN. "WHOLE GENOME IDENTITY-BY-DESCENT DETERMINATION." Journal of Bioinformatics and Computational Biology 11, no. 02 (2013): 1350002. http://dx.doi.org/10.1142/s0219720013500029.

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High-throughput single nucleotide polymorphism genotyping assays conveniently produce genotype data for genome-wide genetic linkage and association studies. For pedigree datasets, the unphased genotype data is used to infer the haplotypes for individuals, according to Mendelian inheritance rules. Linkage studies can then locate putative chromosomal regions based on the haplotype allele sharing among the pedigree members and their disease status. Most existing haplotyping programs require rather strict pedigree structures and return a single inferred solution for downstream analysis. In this re

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21

Pook, Torsten, Martin Schlather, Gustavo de los Campos, Manfred Mayer, Chris Carolin Schoen, and Henner Simianer. "HaploBlocker: Creation of Subgroup-Specific Haplotype Blocks and Libraries." Genetics 212, no. 4 (2019): 1045–61. http://dx.doi.org/10.1534/genetics.119.302283.

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22

Siti. "Bayesian Determination of Disease Associated Differences in Haplotype Blocks." American Journal of Bioinformatics 1, no. 1 (2012): 20–29. http://dx.doi.org/10.3844/ajbsp.2012.20.29.

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23

Otte, Kathrin A., and Christian Schlötterer. "Detecting selected haplotype blocks in evolve and resequence experiments." Molecular Ecology Resources 21, no. 1 (2020): 93–109. http://dx.doi.org/10.1111/1755-0998.13244.

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24

Cardon, Lon R., and Gonçalo R. Abecasis. "Using haplotype blocks to map human complex trait loci." Trends in Genetics 19, no. 3 (2003): 135–40. http://dx.doi.org/10.1016/s0168-9525(03)00022-2.

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25

Gabriel, S. B. "The Structure of Haplotype Blocks in the Human Genome." Science 296, no. 5576 (2002): 2225–29. http://dx.doi.org/10.1126/science.1069424.

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26

Wall, Jeffrey D., and Jonathan K. Pritchard. "Haplotype blocks and linkage disequilibrium in the human genome." Nature Reviews Genetics 4, no. 8 (2003): 587–97. http://dx.doi.org/10.1038/nrg1123.

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27

Sedghifar, Alisa, Yaniv Brandvain, and Peter Ralph. "Beyond clines: lineages and haplotype blocks in hybrid zones." Molecular Ecology 25, no. 11 (2016): 2559–76. http://dx.doi.org/10.1111/mec.13677.

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28

Sun, Jiajie, Yuan Gao, Dong Liu, et al. "Haplotype combination of the bovine INSIG1 gene sequence variants and association with growth traits in Nanyang cattle." Genome 55, no. 6 (2012): 429–36. http://dx.doi.org/10.1139/g2012-029.

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The insulin-induced gene 1 (INSIG1) gene encodes a protein that blocks proteolytic activation of sterol regulatory element binding proteins, which are transcription factors that activate genes that regulate cholesterol, fatty acid, and glucose metabolism. However, similar research for the bovine INSIG1 gene is lacking. Therefore, in this study, polymorphisms of the bovine INSIG1 gene were detected in 643 individuals from four cattle breeds by DNA pooling, forced PCR–RFLP, PCR–SSCP, and DNA sequencing methods. Only 10 novel SNPs were identified, which included four mutations in the coding regio

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29

Papachristou, Charalampos, and Swati Biswas. "Comparison of haplotype-based tests for detecting gene–environment interactions with rare variants." Briefings in Bioinformatics 21, no. 3 (2019): 851–62. http://dx.doi.org/10.1093/bib/bbz031.

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Abstract Dissecting the genetic mechanism underlying a complex disease hinges on discovering gene–environment interactions (GXE). However, detecting GXE is a challenging problem especially when the genetic variants under study are rare. Haplotype-based tests have several advantages over the so-called collapsing tests for detecting rare variants as highlighted in recent literature. Thus, it is of practical interest to compare haplotype-based tests for detecting GXE including the recent ones developed specifically for rare haplotypes. We compare the following methods: haplo.glm, hapassoc, HapReg

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30

Blomhoff, A., M. Olsson, S. Johansson, et al. "Linkage disequilibrium and haplotype blocks in the MHC vary in an HLA haplotype specific manner assessed mainly by DRB1*03 and DRB1*04 haplotypes." Genes & Immunity 7, no. 2 (2006): 130–40. http://dx.doi.org/10.1038/sj.gene.6364272.

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31

Naji, Maulana, Cord Drögemüller, Gábor Mészáros, and Johann Sölkner. "Deviation Patterns of Observed and Expected Haplotype Blocks Associated with Potential Recessive Disorders in Tyrol Grey Cattle." Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis 67, no. 5 (2019): 1183–88. http://dx.doi.org/10.11118/actaun201967051183.

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Confirmed by phenotypic records, several studies across different breeds in different locations have linked missing homozygous pattern with several defects in the functional system and recessive genetic disorders. Recessive genetic diseases are expressed when the recessive alleles appear in a homozygous state for an individual. One of the indicators to detect the recessive allele is through haplotypes, which have a normal frequency in the population, but never occur in the homozygous state. In this study, we used SNP genotypes of 220 Austrian Tyrol Grey cattle and 80 Italian Tyrol Grey cattle

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32

Anderson, Eric C., and Montgomery Slatkin. "Population-Genetic Basis of Haplotype Blocks in the 5q31 Region." American Journal of Human Genetics 74, no. 1 (2004): 40–49. http://dx.doi.org/10.1086/381040.

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33

Nothnagel, Michael, and Klaus Rohde. "The Effect of Single-Nucleotide Polymorphism Marker Selection on Patterns of Haplotype Blocks and Haplotype Frequency Estimates." American Journal of Human Genetics 77, no. 6 (2005): 988–98. http://dx.doi.org/10.1086/498175.

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34

Haddad, Dania, Sumi Elsa John, Anwar Mohammad, et al. "SARS-CoV-2: Possible recombination and emergence of potentially more virulent strains." PLOS ONE 16, no. 5 (2021): e0251368. http://dx.doi.org/10.1371/journal.pone.0251368.

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COVID-19 is challenging healthcare preparedness, world economies, and livelihoods. The infection and death rates associated with this pandemic are strikingly variable in different countries. To elucidate this discrepancy, we analyzed 2431 early spread SARS-CoV-2 sequences from GISAID. We estimated continental-wise admixture proportions, assessed haplotype block estimation, and tested for the presence or absence of strains’ recombination. Herein, we identified 1010 unique missense mutations and seven different SARS-CoV-2 clusters. In samples from Asia, a small haplotype block was identified, wh

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35

QIAO, Ling, Cheng LIU, Xing-Wei ZHENG, et al. "Genetic Analysis of Haplotype-blocks from Wheat Founder Parent Linfen 5064." Acta Agronomica Sinica 44, no. 6 (2018): 931. http://dx.doi.org/10.3724/sp.j.1006.2018.00931.

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36

Twells, R. C. J. "Haplotype Structure, LD Blocks, and Uneven Recombination Within the LRP5 Gene." Genome Research 13, no. 5 (2003): 845–55. http://dx.doi.org/10.1101/gr.563703.

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37

Nothnagel, M., R. Fürst, and K. Rohde. "Entropy as a Measure for Linkage Disequilibrium over Multilocus Haplotype Blocks." Human Heredity 54, no. 4 (2002): 186–98. http://dx.doi.org/10.1159/000070664.

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38

Osabe, Dai, Toshihito Tanahashi, Kyoko Nomura, et al. "Evaluation of sample size effect on the identification of haplotype blocks." BMC Bioinformatics 8, no. 1 (2007): 200. http://dx.doi.org/10.1186/1471-2105-8-200.

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39

Su, S. C., C. C. J. Kuo, and T. Chen. "Inference of missing SNPs and information quantity measurements for haplotype blocks." Bioinformatics 21, no. 9 (2005): 2001–7. http://dx.doi.org/10.1093/bioinformatics/bti261.

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40

Costas, Javier, Antonio Salas, Christopher Phillips, and Ángel Carracedo. "Human genome-wide screen of haplotype-like blocks of reduced diversity." Gene 349 (April 2005): 219–25. http://dx.doi.org/10.1016/j.gene.2004.12.042.

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41

Ma, Xiaoming, Congjun Jia, Donghai Fu, et al. "Analysis of Hematological Traits in Polled Yak by Genome-Wide Association Studies Using Individual SNPs and Haplotypes." Genes 10, no. 6 (2019): 463. http://dx.doi.org/10.3390/genes10060463.

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Yak (Bos grunniens) is an important domestic animal living in high-altitude plateaus. Due to inadequate disease prevention, each year, the yak industry suffers significant economic losses. The identification of causal genes that affect blood- and immunity-related cells could provide preliminary reference guidelines for the prevention of diseases in the population of yaks. The genome-wide association studies (GWASs) utilizing a single-marker or haplotype method were employed to analyze 15 hematological traits in the genome of 315 unrelated yaks. Single-marker GWASs identified a total of 43 sign

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Wijayatunga, Nadeeja, Lili Ding, and Chandrika Piyathilake. "Ancestry-Specific Interactions Between Circulatory Folate and One-Carbon Metabolism Genes’ Haplotypes for Higher-Grade Cervical Intraepithelial Neoplasia." Current Developments in Nutrition 5, Supplement_2 (2021): 285. http://dx.doi.org/10.1093/cdn/nzab036_027.

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Abstract Objectives Determine ancestry-specific interactions between circulatory folate concentrations, haplotypes of the one-carbon (1C) pathway genes and risk of higher-grade cervical intraepithelial neoplasia (CIN2+) in the US post-folic acid fortification era. Methods Study included self-reported African American and Caucasian American women positive for high-risk human papillomavirus (HPV) genotypes and diagnosed with ≤ CIN1 (non-cases, n = 340) or CIN2+ (cases, n = 337). Plasma and red blood cell (RBC) folate, vitamins B12 (B12) and C, and total carotene levels were measured. 660 single

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43

Pe’er, Itsik, and Jacques S. Beckmann. "Recovering Frequencies of Known Haplotype Blocks From Single-Nucleotide Polymorphism Allele Frequencies." Genetics 166, no. 4 (2004): 2001–6. http://dx.doi.org/10.1093/genetics/166.4.2001.

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Abstract Prospects for large-scale association studies rely on economical methods and powerful analysis. Representing available SNPs by small subsets and measuring allele frequencies on pooled DNA samples each improve genotyping cost effectiveness, while haplotype analysis may highlight associations in otherwise underpowered studies. This manuscript provides the mathematical framework to integrate these methodologies.

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44

Finke, Kelly, Michael Kourakos, Gabriela Brown, et al. "Ancestral haplotype reconstruction in endogamous populations using identity-by-descent." PLOS Computational Biology 17, no. 2 (2021): e1008638. http://dx.doi.org/10.1371/journal.pcbi.1008638.

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In this work we develop a novel algorithm for reconstructing the genomes of ancestral individuals, given genotype or sequence data from contemporary individuals and an extended pedigree of family relationships. A pedigree with complete genomes for every individual enables the study of allele frequency dynamics and haplotype diversity across generations, including deviations from neutrality such as transmission distortion. When studying heritable diseases, ancestral haplotypes can be used to augment genome-wide association studies and track disease inheritance patterns. The building blocks of o

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Pe'er, I. "Recovering Frequencies of Known Haplotype Blocks From Single-Nucleotide Polymorphism Allele Frequencies." Genetics 166, no. 4 (2004): 2001–6. http://dx.doi.org/10.1534/genetics.166.4.2001.

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46

Hiroaki, Nakahara, Fujii Koji, Kitayama Tetsushi, Sekiguchi Kazumasa, Nakanishi Hiroaki, and Saito Kazuyuki. "Approaches for identifying multiple-SNP haplotype blocks for use in human identification." Legal Medicine 17, no. 5 (2015): 415–20. http://dx.doi.org/10.1016/j.legalmed.2015.06.003.

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47

Schulze, Thomas G., Kui Zhang, Yu-Sheng Chen, Nirmala Akula, Fengzhu Sun, and Francis J. McMahon. "Defining haplotype blocks and tag single-nucleotide polymorphisms in the human genome." Human Molecular Genetics 13, no. 3 (2003): 335–42. http://dx.doi.org/10.1093/hmg/ddh035.

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48

Mannila, H., M. Koivisto, M. Perola, et al. "Minimum Description Length Block Finder, a Method to Identify Haplotype Blocks and to Compare the Strength of Block Boundaries." American Journal of Human Genetics 73, no. 1 (2003): 86–94. http://dx.doi.org/10.1086/376438.

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49

Hadsell, D. L., J. Wei, W. Olea, et al. "In silico QTL mapping of maternal nurturing ability with the mouse diversity panel." Physiological Genomics 44, no. 16 (2012): 787–98. http://dx.doi.org/10.1152/physiolgenomics.00159.2011.

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Significant variation exists for maternal nurturing ability in inbred mice. Although classical mapping approaches have identified quantitative trait loci (QTL) that may account for this variation, the underlying genes are unknown. In this study, lactation performance data among the mouse diversity panel were used to map genomic regions associated with this variation. Females from each of 32 inbred strains ( n = 8–19 dams/strain) were studied during the first 8 days of lactation by allowing them to raise weight- and size-normalized cross-foster litters (10 pups/litter). Average daily weight gai

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Smedfors, Gabriella, Franziska Liesecke, Caroline Ran, Lars Olson, Tobias E. Karlsson, and Andrea Carmine Belin. "Genetic Screening of Plasticity Regulating Nogo-Type Signaling Genes in Migraine." Brain Sciences 10, no. 1 (2019): 5. http://dx.doi.org/10.3390/brainsci10010005.

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Abstract:

Migraine is the sixth most prevalent disease in the world and a substantial number of experiments have been conducted to analyze potential differences between the migraine brain and the healthy brain. Results from these investigations point to the possibility that development and aggravation of migraine may include grey matter plasticity. Nogo-type signaling is a potent plasticity regulating system in the CNS and consists of ligands, receptors, co-receptors and modulators with a dynamic age- and activity-related expression in cortical and subcortical regions. Here we investigated a potential l

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