Academic literature on the topic 'Hard Drugs'

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Journal articles on the topic "Hard Drugs"

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Sharp, D. "Hard Drugs and "British" Solutions." Journal of Urban Health: Bulletin of the New York Academy of Medicine 80, no. 2 (2003): 171–72. http://dx.doi.org/10.1093/jurban/jtg037.

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Bohannon, J. "PUBLIC HEALTH: Hard Data on Hard Drugs, Grabbed From the Environment." Science 316, no. 5821 (2007): 42–44. http://dx.doi.org/10.1126/science.316.5821.42.

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Erawati, Ambar Dwi, and Okti Trihastuti Dyah Retnaningrum. "Pemanfaatan Video Edukasi Dalam Rangka Penguatan Kesadaran Hukum Penggunaan Obat Keras Di SMA N 7 Kota Semarang." Jurnal Pengabdian Masyarakat (ABDIRA) 4, no. 3 (2024): 10–15. http://dx.doi.org/10.31004/abdira.v4i3.468.

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Gevaarlijk drugs are drugs that should not be traded freely because hard drugs harm the body if used irrationally. The abuse of hard drugs is often abused by the community, especially students. The method used is to provide assistance with 1 time of counseling, mentoring and 1 evaluation, then the video is shared with students of SMA N 7 Semarang class X to be used and can be spread to other friends. The target of this activity is that SMA 7 students understand hard drugs and be careful in their use. The service implementation team made an educational video that can be used by teenagers to avo
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Melberg, Hans Olav, Andrew M. Jones, and Anne Line Bretteville-Jensen. "Is cannabis a gateway to hard drugs?" Empirical Economics 38, no. 3 (2009): 583–603. http://dx.doi.org/10.1007/s00181-009-0280-z.

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Rea, Rustam. "New drugs, but old habits die hard!" Practical Diabetes 31, no. 9 (2014): 360. http://dx.doi.org/10.1002/pdi.1902.

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Crewe, Ben. "Prisoner society in the era of hard drugs." Punishment & Society 7, no. 4 (2005): 457–81. http://dx.doi.org/10.1177/1462474505057122.

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Sysak, T. "Seeking hard data on adverse effects of drugs." Canadian Medical Association Journal 184, no. 8 (2012): E405—E406. http://dx.doi.org/10.1503/cmaj.109-4152.

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Marditia, Putri Purbasari Raharningtyas, and Putu Devi Kuaumawardani. "Marketplace Accountability Regulatory Model for the Online Distribution of Hard Drugs (Prescription Drugs)." SOEPRA 8, no. 1 (2022): 106–19. http://dx.doi.org/10.24167/shk.v8i1.4760.

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Donnermeyer, Joseph F. "Rural Youth Usage of Alcohol, Marijuana, and “Hard” Drugs." International Journal of the Addictions 28, no. 3 (1993): 249–55. http://dx.doi.org/10.3109/10826089309039626.

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Woods, W. E., Sylvia Chay, T. Houston, J. W. Blake, and Thomas Tobin. "Efficacy of testing for illegal medication in horses." Journal of the American Veterinary Medical Association 187, no. 9 (1985): 927–30. https://doi.org/10.2460/javma.1985.187.09.927.

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SUMMARY The efficacy of testing for illegal drugs in race horses was surveyed by evaluating 27 questionnaires received from 28 racing jurisdictions polled. Large variations in the number of samples tested and drugs detected were reported. Some jurisdictions reported only illegal medications, whereas others also reported permitted medications. To facilitate comparison, stimulants, depressants, local anesthetics, narcotic analgesics, and tranquilizers were classified as hard drugs. Other drugs, which are legal in some jurisdictions, were classified as soft. To evaluate the efficacy of testing, p
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Dissertations / Theses on the topic "Hard Drugs"

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Gutebrand, Kristoffer. "Ett Drogfritt Samhälle : En filosofisk förfrågan om Sveriges narkotikapolitik." Thesis, Umeå universitet, Institutionen för idé- och samhällsstudier, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-140427.

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Sveriges narkotikapolitik har en tydlig noll vision; Sverige skall bli ett drogfritt samhälle. För att uppnå det målet följer Sverige en så kallad nolltoleransmodell, vilket innebär en strikt policy som säger att all hantering och bruk oavsett volym och syfte är olagligt. Jag argumenterar att det är en skadlig och ineffektiv policy att applicera på drogproblematiken i Sverige och argumenterar därför istället för att införa en så kallad skadereducerande policy. Detta är istället en policy som accepterar att droger är en del av samhället. En sådan policy jobbar främst med förebyggande och behand
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Coull, Alison Frances. "Leg ulceration in young people who inject drugs : causative factors, and how harm may be reduced : a mixed methods approach." Thesis, University of Stirling, 2016. http://hdl.handle.net/1893/24081.

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The thesis explores chronic leg ulceration experienced by young people who inject drugs (PWID). The applied health research study, in two phases, used a sequential explanatory mixed methods design. Phase 1 involved a survey of 200 people who injected drugs to investigate the prevalence of skin problems and leg ulceration, together with the identification of risk factors for ulceration. Phase 2 involved a series of fifteen qualitative semi-structured interviews that explored the results relating to risk factors with a sample of PWID who had experienced leg ulceration, and investigated participa
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Septiadi, Dedy. "Optical imaging and drug delivery using soft- and hard- nanomaterials." Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAF036/document.

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Le travail décrit dans cette thèse se concentre sur le développement de matériaux « durs et mous » ainsi que leur interaction avec les cellules biologiques pour une application finale dans le domaine de la théranostique couvrant l'imagerie, la détection, la thérapie génique et la thérapie du cancer. Dans ce contexte, nous avons tout d'abord étudié l'utilisation de complexes (II) de platine phosphorescents auto-assemblés comme sonde cellulaire. Nous avons étendu l'idée de bio-imagerie en introduisant un concept d’imagerie basée sur l’émission stimulée où nous étions en mesure de générer un lase
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Kosinski, Jake M. "Drug Markets and the State: A Perspective from Political Economy." Oberlin College Honors Theses / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=oberlin1411564078.

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Dordunoo, Stephen Kwaku. "Characterization of drug-carrier systems for liquid filling of hard gelatin capsules." Thesis, Liverpool John Moores University, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261411.

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Beem, Amanda. "Governing cannabis highs and harms: Australia's neoliberal harm minimisation illicit drugs framework." Thesis, Queensland University of Technology, 2020. https://eprints.qut.edu.au/203745/1/Amanda_Beem_Thesis.pdf.

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This thesis applies Bacchi's (2009; 2016) policy analysis framework, to Australian illicit drug policy texts (1985–2017) to interrogate exercises of power in illicit drug policy. Findings reveal the dominance of legal and health/well-being discourses which produce the body as a site of self-governance ('responsibilisation'), while epidemiological narratives narrow the cannabis 'problem' and omit why cannabis is used for recreation. Failure to resolve the historical influence of morality associated with public health rationalities and their intersection with law and order has meant that harm mi
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Bond, Ethan J. "A Ban on Performance - Enhancing Drugs? Harm, Nature of Sport and Dehumanization." Scholarship @ Claremont, 2011. http://scholarship.claremont.edu/cmc_theses/248.

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In this paper, I seek to determine whether the current ban on performance-enhancing drugs (PEDs) in professional sport is justified. I look at two of the most common categories of arguments in favor of the ban, which I term the Harm Category and The Nature of Sport Category, and ultimately determine that neither is strong enough to justify the current ban. I determine, however, that a third and less common category of arguments, which I term the Dehumanization Category, provides good reason to justify the ban by appealing to our intuitions about why the use of PEDs in professional sport is wro
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Pereira, Margaret A. "Governing drug use among young people : crime, harm and contemporary drug use practices." Thesis, Queensland University of Technology, 2013. https://eprints.qut.edu.au/63631/1/Margaret_Pereira_Thesis.pdf.

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Taking an empirical, critical approach to the problem of drugs, this thesis explores the interaction of drug policies and young people's drug use in Brisbane. The research argues that criminalising drug users does not usually prevent harmful drug use, but it can exacerbate harm and change how young people use drugs. Contemporary understandings of drug use as either recreational or addictive can create a false binary, and influence how illicit drugs are used. These understandings interact with policy responses to the drug problem, with some very real implications for the lived experiences of dr
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Small, William. "Injection settings and drug-related harm in Vancouver, Canada." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/25983.

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Ecological approaches to addressing injection-related risk seek to reduce drug-related harm by identifying and removing environmental barriers to risk-reduction. While the settings where drugs are injected represent a key location for these efforts, further knowledge regarding the role of injection settings is required to understand and address context-specific barriers to risk-reduction. This thesis sought to employ the risk environment framework and use ethnographic methods to examine two key types of injection settings, public injection venues and a local supervised injection facility (SIF)
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Degenstein, Dane. "The War on Drugs and Social Policy in Tanzania: Crackdowns, Prohibition and Control." Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/41209.

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In February 2017, Tanzanian President John Magufuli publicly declared a war on drugs, an unexpected change in policy in a country previously leading the way in harm reduction in Sub-Saharan Africa. The war on drugs, a set of policies aimed at reducing drug supply and use through the punishment, forced treatment and criminalization of drug users, is a part of Magufuli’s strategy to ‘clean up’ Tanzanian society. Prior to his election, the Tanzanian government largely ignored treatment and drug policy, and foreign NGOs, in partnership with local activists, funded and implemented harm reduction in
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Books on the topic "Hard Drugs"

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Marankos, Tasos. Hard rock: School, drugs & rock n' roll. 2nd ed. Jemma Press, 2018.

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K, Ridgway, ed. Hard capsules: Development and technology. Pharmaceutical Press, 1987.

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Mensah, Isaac Dankyi. The story of Akwasi Ata: Hard drugs are dangerous. Quick Service Books, 2000.

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Great Britain. Parliament. House of Commons. Social Services Committee. Misuse of drugs with special reference to the treatment andrehabilitation of misusers of hard drugs. H.M.S.O., 1985.

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Faupel, Charles E. Shooting dope: Career patterns of hard-core heroin users. University of Florida Press, 1991.

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Strong, Arturo Carrillo. Corrido de cocaine: Inside stories of hard drugs, big money, and short lives. Harbinger House, 1990.

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Security, Great Britain Department of Health and Social. Misuse of drugs: With special reference to the treatment and rehabilitation of misusers of hard drugs : Government response to the 4th report from the Social Services Committee Session 1984-85. HMSO, 1985.

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Great Britain. Parliament. House of Commons. Social Services Committee., Great Britain. Dept. of Health and Social Security., Great Britain. Manpower Services Commission., Great Britain Home Office, and Great Britain. Dept. of Education and Science., eds. Misuse of drugs with special reference to the treatment and rehabilitation of misusers of hard drugs: Government response to the fourth report from the Social Services Committee session 1984-85. HMSO, 1985.

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Britain, Great. Misuse of drugs: With special reference to the treatment and rehabilitation of misusers of hard drugs : Government response to the fourth report from the Social Services Committee session 1984-85. HMSO, 1985.

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Great Britain. Parliament. House of Commons. Social Services Committee. Fourth report from the Social Services Committee session 1984-85: Misuse of drugs : with special reference to the treatment and rehabilitation of misusers of hard drugs : together with the proceedings of the Committee and the minutes of evidence. HMSO, 1985.

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Book chapters on the topic "Hard Drugs"

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Freye, Enno. "Positive Signs and Symptoms of Hard Drug Abuse." In Pharmacology and Abuse of Cocaine, Amphetamines, Ecstasy and Related Designer Drugs. Springer Netherlands, 2009. http://dx.doi.org/10.1007/978-90-481-2448-0_41.

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Goldberg, Ted. "Harm Reduction — Dutch Narcotics Policy." In Demystifying Drugs. Palgrave Macmillan UK, 1999. http://dx.doi.org/10.1007/978-1-349-27618-9_13.

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Sandul, Amy L., and Veda B. Moore. "Harm Reduction: Tipping the Balance Toward Treatment and Recovery." In Public Health Ethics Analysis. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-92080-7_10.

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AbstractOpioid use has risen dramatically over the past 40 years. In response, federal programs and policies aimed at decreasing supply of prescription opioids have stabilized excessive prescribing. Unintended consequences of limiting the quantity of prescription opioids in the population has resulted in increased use of illicit drugs and opened a pathway of transition from misuse of pills to injection of heroin and use of potent formulations of cheap, synthetic opioids such as fentanyl. Harm reduction interventions function at the community level to provide health benefits and avoidance of ha
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Engström, Alina. "Antimicrobial Resistance as a Creeping Crisis." In Understanding the Creeping Crisis. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-70692-0_2.

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AbstractAntimicrobial resistance (AMR) displays many of the characteristics of a creeping crisis. It lacks clearly definable temporal and spatial boundaries. It develops in the natural world when and where conditions are conducive. It traverses sectors and borders in the natural, human, and built environments. It causes individual and societal harm when it escalates toward outbreaks in a random fashion. Outbreaks can be minor or major, burn fast or slow, be simple or hard to contain. Experts insist we are heading toward a “post-antibiotic age” and even deadlier “superbugs” if we do not act. Ye
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Keene, Jan. "Harm minimization." In Drug Misuse. Springer US, 1997. http://dx.doi.org/10.1007/978-1-4899-3300-3_7.

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Coomber, Ross, Matthew Bacon, Jack Spicer, and Leah Moyle. "Symbolic drugs policing." In Drug Law Enforcement, Policing and Harm Reduction. Routledge, 2022. http://dx.doi.org/10.4324/9781003154136-5.

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"Hard drugs." In Grey Area. UCL Press, 2019. http://dx.doi.org/10.2307/j.ctv8xnh8p.12.

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"Reforming the Laws on Hard Drugs." In Drugs. Routledge, 2012. http://dx.doi.org/10.4324/9780203886595-24.

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Newbold, Greg. "The Control of Drugs in New Zealand." In Hard Lessons. Routledge, 2019. http://dx.doi.org/10.4324/9781351156806-4.

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Milward, John. "Hard- Core Troubadours." In Americanaland. University of Illinois Press, 2021. http://dx.doi.org/10.5622/illinois/9780252043918.003.0015.

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This chapter details how, at MCA (Music Corporation of America), Jimmy Bowen signed artists whom he might have met backstage at an Emmylou Harris show, including a trio of singer-songwriters from Texas: Nanci Griffith, Lyle Lovett, and the wild card of the bunch, Steve Earle. Earle had bounced in and out of Nashville for a decade. A singer-songwriter who grew up on rock, he cut a rockabilly record for Epic that went unreleased until his MCA debut became a hit. Since he had grown up as a fan of rock and roll, Earle made a country record that could also appeal to rockers. However, Steve Earle's
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Conference papers on the topic "Hard Drugs"

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Bogdan, P. M., I. V. Konovalova, and A. G. Klykov. "Evaluation of the parameters of adaptivity of soft and hard wheat varieties using methods of mathematical analysis." In MODERN SYNTHETIC METHODOLOGIES FOR CREATING DRUGS AND FUNCTIONAL MATERIALS (MOSM2020): PROCEEDINGS OF THE IV INTERNATIONAL CONFERENCE. AIP Publishing, 2021. http://dx.doi.org/10.1063/5.0068330.

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Wang, Xiaoliang, Hongchen Gu, and Xinyuan Zhu. "A Novel Remote Controllable Drug Delivery System Triggered by Heating From Magnetic Nanoparticles." In ASME 2009 Second International Conference on Micro/Nanoscale Heat and Mass Transfer. ASMEDC, 2009. http://dx.doi.org/10.1115/mnhmt2009-18052.

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Target drug delivery is one of the core issues in modern medicine. Although both thermo-sensitive and magnetic drug vehicles have been developed for this purpose, reliable drug targeting is yet to achieve, because it’s hard to control local temperature in body for thermo-sensitive drugs, and it’s also difficult to control the colloidal sizes of magnetic vehicles to meet the requirements for both long-time circulation and magnetic responsibility. Here we present a new technology to solve these two problems. The drug (taxel) was combined with hyper-branched thermo-sensitive polymer and magnetic
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M, Saranya, Arockia Xavier Annie R, and Geetha T V. "Relation Extraction between Biomedical Entities from Literature using Semi- Supervised Learning Approach." In 10th International Conference on Natural Language Processing (NLP 2021). Academy and Industry Research Collaboration Center (AIRCC), 2021. http://dx.doi.org/10.5121/csit.2021.112306.

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Now-a-days, people around the world are infected by many new diseases. The cost of developing or discovering a new drug for the newly discovered disease is very high and prolonged process. These could be eliminated with the help of already existing resources. To identify the candidates from the existing drugs, we need to extract the relation between the drug, target and disease by textming a large-scale literature. Recently, computational approaches which is used for identifying the relationships between the entities in biomedical domain are appearing as an active area of research for drug dis
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Amer, Samar A., and Sami I. Almudarra. "Assessment of Drug Use Pattern among Hajj Pilgrims Saudi Arabia, 1439h (2018)." In 2nd International Conference on Public Health and Well-being. iConferences (Pvt) Ltd, 2022. http://dx.doi.org/10.32789/publichealth.2021.1009.

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Hajj pilgrimage is the biggest and longest mass gathering, thus increasing the risk of communicable and non-communicable diseases, so this study aimed to promote rational drug use and optimum provision of drugs among Hajj 1439 Pilgrims through the following objectives: To determine the prevalence and the context of the drug's use and to assess the drug use patterns among pilgrims. METHODS: A cross-sectional study was carried out on randomly selected 785 Hajj Pilgrims, stratified according to their countries before their retrial in King Abdul Aziz Airport in Jeddah: The studied pilgrims were 52
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Carr, Rachel, Justin Halim, Rebecca Fliorent, Henry Fraimow, Dejan Nikolic, and Valerie Carabetta. "Characterization of Antibiotic Susceptibility Profiles of Extensively- and Pan-Drug Resistant Acinetobacter Baumannii Clinical Isolates." In 27th Annual Rowan-Virtua Research Day. Rowan University Libraries, 2023. https://doi.org/10.31986/issn.2689-0690_rdw.stratford_research_day.96_2023.

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Acinetobacter baumannii is an opportunistic pathogen common in intensive care units (ICUs), particularly among immunocompromised individuals. Nosocomial A. baumannii infections have become increasingly problematic in recent years, as these bacteria rapidly acquire antibiotic resistance, leading to the emergence of multidrug, extensively drug and pan drug-resistant (MDR, XDR, and PDR, respectively) isolates. Recently, Cooper University Hospital (CUH) experienced a large increase in highly drug-resistant A. baumannii infections, which had a mortality rate of 60%. Oftentimes, physicians had to tu
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Ramkumar, Barathram, and D. Subbaram Naidu. "Closed-Loop Optimal Control Strategy for Cancer Chemotherapy." In ASME 2007 International Mechanical Engineering Congress and Exposition. ASMEDC, 2007. http://dx.doi.org/10.1115/imece2007-43527.

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Cancer chemotherapy is the treatment of cancer using drugs that kill the cancer cells, when the drugs are administered either orally or through veins. The drugs are delivered according to a schedule so that a particular dosage of drug level is maintained in the body. The disadvantage of these drugs is that they not only kill the cancer cells but also kill the normal healthy cells. The role of optimal control in chemotherapy is to maintain an optimum amount of drug level in the body so that only cancer cells are killed and hence the effect of drug on the healthy cells is minimized. Three differ
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Azeez, Abolaji, Olubukola Yetunde Azeez, and Matthew Ayegboyin. "Breeding Drug Abusers: Patent Medicine Vendors Experiences in Semi-Urban Areas of Ibadan, Nigeria." In 28th iSTEAMS Multidisciplinary Research Conference AIUWA The Gambia. Society for Multidisciplinary and Advanced Research Techniques - Creative Research Publishers, 2021. http://dx.doi.org/10.22624/aims/isteams-2021/v28n2p12.

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Indiscriminate drug use consistently constitutes a public health threat in developing countries including Nigeria. Therefore, the study explored PMVs’ experiences to understand the socio-economic factors accountable for the demand and dispensation of multiple drugs to clients. The study was exploratory and qualitative. Through respondents determined survey (RDS), four patent medicine vendors and one pharmacist were recruited into the study for in-depth interviews. The PMVs had at least 7 years’ experience and were aware of the restrictions guiding drugs they could sell. Although PMVs were proh
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Ullah, Aman, Huiqi Wang, and Rehan Pradhan. "Lipid Derived Block Copolymers as Amphiphilic Nanocarriers for Targeted Delivery." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/bfgi9101.

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Amphiphilic thermoresponsive block copolymers and ABA type PEG-Lipid conjugated macromolecules have been synthesized using microwave-assisted reversible addition-fragmentation chain transfer (RAFT) polymerization and the copper-catalyzed azide-alkyne cycloaddition, commonly termed “click chemistry”, respectively. Characterization of the block copolymers and conjugates has been carried out with the help of 1H-NMR, FTIR and GPC. These copolymers and conjugates were evaluated for the encapsulation and release of drugs. Carbamazepine, an anticonvulsant drug with poor water solubility was selected
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Albuquerque, Pedro José Honório de, Laura Guerra Lopes, Jordy Silva de Carvalho, Luzilene Pereira de Lima, and Marina Galdino da Rocha Pitta. "Emerging therapies for amyotrophic lateral sclerosis applied to drug discovery." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.021.

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Background: Amyotrophic Lateral Sclerosis (ALS) is a progressive neuromuscular disease mainly caused by genetic disorders. This progressive disorder involves the degeneration of motor neurons at various levels. Drugs have been studied, and they show improvement in survival and reduced progression of the disease, they are riluzole and edaravone. Objectives: Investigate emerging therapies for the treatment of ALS. Methods: The Pubmed database was used to conduct the research, and the keywords were “Amyotrophic Lateral Sclerosis”, “Emerging”, “Therapies”,”Drugs”, all present in Mesh. Articles fro
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Oliveira, Ricardo F., Senhorinha F. Teixeira, Helena Maria Cabral Marques, and José Carlos Teixeira. "A Correlative CFD Study Between Recirculation Area and FPM in VHC Design." In ASME 2016 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/imece2016-67329.

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A major part of asthma treatment is made by the use of preventive inhalation drugs. The Pressurized Metered-Dose Inhalator (pMDI) has been the backbone device for this treatment, due to its simplicity, portability and widely acceptance. But no device comes without its limitations, and pMDI is hard to handle properly by elders and children < 5 years old, resulting in reduced amount of drug to the patient lungs. Add-on devices (e.g. spacers) were developed to mitigate the need for coordination and reduce the oral/throat deposition, namely the Valved Holding Chambers (VHC). These devices are i
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Reports on the topic "Hard Drugs"

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Venedicto, Melissa, and Cheng-Yu Lai. Facilitated Release of Doxorubicin from Biodegradable Mesoporous Silica Nanoparticles. Florida International University, 2021. http://dx.doi.org/10.25148/mmeurs.009774.

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Cervical cancer is one of the most common causes of cancer death for women in the United States. The current treatment with chemotherapy drugs has significant side effects and may cause harm to healthy cells rather than cancer cells. In order to combat the potential side effects, nanoparticles composed of mesoporous silica were created to house the chemotherapy drug doxorubicin (DOX). The silica network contains the drug, and a pH study was conducted to determine the conditions for the nanoparticle to disperse the drug. The introduction of disulfide bonds within the nanoparticle created a fram
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Rujiravanit, Ratana. Preparation and characterization of hydrogel from chitin derivative and silk fibroin. Thailand Research Fund, 2003. https://doi.org/10.58837/chula.res.2003.80.

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Natural polymer blend films composed of chitosan and silk fibroin were prepared by solution casting technique with various ratios of chitosan to silk fibroin, using glutaraldehyde as crosslinking agent. The effects of the ratio of chitosan to silk fibroin and crosslinking agent on mechanical properties, swelling behavior and drug releasing property of the blend films were studied. For the swelling behavior, the blend films exhibited a dramatic change in the degree of swelling when immersed in acidic solutions. The blend film with 80% chitosan content had the maximum degree of swelling. It appe
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Wen, Hefei, Jason Hockenberry, and Janet Cummings. The Effect of Medical Marijuana Laws on Marijuana, Alcohol, and Hard Drug Use. National Bureau of Economic Research, 2014. http://dx.doi.org/10.3386/w20085.

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Grueso-Navarro, Elena, Leticia Rodríguez-Alcolado, Ángel Arias, Emilio J. Laserna-Mendieta та Alfredo J. Lucendo. Influence of HLA-DQA1*05 allele in the response to anti-TNFα drugs in inflammatory bowel diseases. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2023. http://dx.doi.org/10.37766/inplasy2023.2.0076.

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Review question / Objective: Do patients with inflammatory bowel disease and treated with any anti-TNFα drug who had the HLA-DQA1*05 allele (in heterozygosis or homozygosis) have lower response or persistence to those drugs than patients without HLA-DQA1*05 allele? Condition being studied: Inflammatory bowel diseases (IBD), which includes Crohn’s disease (CD) and ulcerative colitis (UC), is a chronic inflammatory condition that may affect any part of the digestive tract (CD) or be limited to the colon (UC). While the specific aetiology of IBD remains unknown, it is believed to involve a comple
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Dong, Chengda, Hongshuo Shi, Zhaojun Yan, and Jianmin Liu. Quality of Evidence Supporting the Role of Nonsteroidal Anti-inflammatory Drugs for the Treatment of Anxious Depression: A protocol for Systematic Review and Meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.8.0029.

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Review question / Objective: Population: the participants had anxious depression diagnosed according to any authoritative diagnostic criteria, no restrictions on sex, race, age, onset time, or the source of cases. Intervention: Nonsteroidal Anti-inflammatory Drugs (NSAIDs), including oral and injectable NSAIDs. Comparison: conventional antidepressants. Outcome:effective rate, Hamilton Depression Rating Scale, Hamilton Anxiety Rating Scale, Treatment Emergent Symptom Scale, potential gastrointestinal and neurological adverse events, etc. Study design: Randomized controlled trial. Information so
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Conteh, Abu. SSHAP West Africa Hub: Addressing the Kush Epidemic in Sierra Leone. Institute of Development Studies, 2024. http://dx.doi.org/10.19088/sshap.2024.060.

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Sierra Leone has seen a sharp rise in the use of ‘kush’ – a relatively new drug formed through mixing several constituent drugs, including opioids, which is proving highly addictive and is having serious negative health and social consequences. In April 2024, the government declared a public health emergency resulting from high levels of kush use, with security services launching crackdowns.1 Limited data on kush use presents challenges to understanding the scale of the problem. The lack of evidence has hampered the government’s response to the kush crisis. This has contributed to a misunderst
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Drake, Keith, and Thomas McGuire. Using Stock Price Movements to Estimate the Harm from Anticompetitive Drug Patent Litigation Settlements. National Bureau of Economic Research, 2024. http://dx.doi.org/10.3386/w33196.

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Zhang, Cheng, and Yue Yang. Impact of adaptive design on reducing the duration of clinical trials in rare cancers: a meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.2.0081.

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Review question / Objective: Whether the application of adaptive design in clinical trials of rare cancers can shorten the duration of clinical trials? Condition being studied: Currently, the development of innovative drug products (InMPs) for rare cancers faces many challenges, including the difficulty of enrolling sufficient numbers of patients from small and heterogeneous patient populations for clinical trials, and the significant risks of high financial investment, long development times and potential failure from a pharmaceutical company's perspective for rare cancer drugs due to limited
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Cheeseman, Kathryn. The Environmental Impacts of Illicit Drug Production. Institute of Development Studies, 2024. http://dx.doi.org/10.19088/k4dd.2024.017.

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This rapid evidence review compiles findings on the environmental impacts of illicit drug production, focusing on water and soil pollution, ecosystem health, land use change, and waste management. It highlights the complexity of the issue, with significant gaps in understanding the long-term effects on ecosystems. The review also examines how prohibitionary drug policies may exacerbate environmental harm. Key findings include distinct regional patterns of drug use, complex relationships between land use change and drug production, and the persistence of biologically active compounds in water s
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O’Reily, Keelin, and Claire Wilkinson. Involuntary treatment for alcohol and other drugs: An Evidence Check rapid review. The Sax Institute, 2024. http://dx.doi.org/10.57022/accg7897.

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Involuntary alcohol and other drug (AOD) treatment is a legal process in which an individual is mandated to receive treatment for substance dependence or addiction against their will. The potential benefits in these circumstances must be assessed against the removal of liberty and possible risks for already vulnerable people. This Evidence Check aimed to understand whether committing individuals to such programs produces positive outcomes, and whether they are comparable to what may have occurred through voluntary treatment. The authors identified 13 publications that met the eligibility crite
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