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Journal articles on the topic 'Hard gelatin capsules'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Sonar, Shivani, Sheetal Gondkar, and Ravindranath B. Saudagar. "Liquid Filled Hard Gelatin Capsule." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 832–35. http://dx.doi.org/10.22270/jddt.v9i3-s.2794.

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Novel dosage forms emerges more and more in recent years. One of them is liquid-filled hard gelatin capsules, which have gelatin or the hydroxypropyl methyl cellulose (HPMC) as capsule shell. The liquid-filled hard gelatin capsule is gradually getting attention because of its new-concept dosage form design, which bring liquid drugs by solid form. The paper mostly presents application, pharmaceutical manufacturing, quality assessment, vision of liquid-filled hard gelatin capsules and emphases on the application and pharmaceutical manufacturing of liquid-filled capsule. It is recommended that th

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Nurilmala, Mala, Noviyan Darmawan, Erin Apriliani Wulandari Putri, Agoes M. Jacoeb, and Tun Tedja Irawadi. "Pangasius Fish Skin and Swim Bladder as Gelatin Sources for Hard Capsule Material." International Journal of Biomaterials 2021 (August 27, 2021): 1–6. http://dx.doi.org/10.1155/2021/6658002.

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In this paper, we report the extraction and characterization of gelatin from the abundant industrial fishery waste of Pangasius skin and swim bladder and its application as the base material for hard capsule shells. The yield of gelatin ranged between 19 and 23%, content of moisture is 7.6–9.2%, ash is 1.1–1.7%, pH is 4.1–5.2, gel strength is 238–278 bloom, and viscosity is 65–74.7% mP. SDS-PAGE showed all gelatins have chains of α1, α2, and β-peptides. The skin, swim bladder, and mixed gelatins were successfully used in the production of hard capsule shells. The dimensions, weight, disintegra

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3

Zilhadia, Zilhadia, Yahdiana Harahap, Irwandi Jaswir, and Effionora Anwar. "Evaluation and Characterization of Hard-Shell Capsules Formulated by Using Goatskin Gelatin." Polymers 14, no. 20 (2022): 4416. http://dx.doi.org/10.3390/polym14204416.

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Gelatin is used as an additive in medicine, food, and cosmetics. Gelatin from goatskin is a new excipient that has not been explored by researchers, including for hard-shell capsules. The aim of this study was to evaluate and characterize the hard-shell capsules produced from goatskin gelatin. The goatskin gelatin was extracted by an acid hydrolysis method, and the functional properties were investigated. Hard-shell capsules were then produced from goatskin gelatin, evaluated, and characterized. The gelatin extracted from goatskin had 56.9% ± 0.95 clarity and a pH of 5.11 ± 0.09, 97.51% ± 1.1

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Ramli, Nur Amalina, Nurul Natasya Amira Kamaluddin, and Fatmawati Adam. "Mechanical, Structural and Physical Properties of Carrageenan-Gum Arabic Biocomposite Film for Hard Capsule Application." Solid State Phenomena 340 (December 23, 2022): 11–18. http://dx.doi.org/10.4028/p-c2wejl.

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The hard capsule market growth is mainly driven by the demand for gelatin capsules made of animals. Plant-based hard capsules, such as hydroxypropyl methylcellulose are currently in high demand for drug delivery, but the manufacturing process is costly with limited reagent supply. As an alternative, carrageenan from seaweed was used as a film-forming agent in this work. Carrageenan film possesses low mechanical strength, thus gum Arabic is incorporated to strengthen the biocomposite film. The films and hard capsules were produced with different concentrations of gum Arabic, ranging from 0 to 2

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Kaur, Darshan. "FORMULATION AND EVALUATION OF HARD GELATIN CAPSULES CONTAINING Bacopa Monnieri." INTERNATIONAL JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH (IJPER) 1, no. 02 (2020): 33–37. http://dx.doi.org/10.37021/ijper.v1i2.2.

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Introduction: The present work deals the formulation of hard gelatin capsules containing granules of Brahmi (Bacopa monnieri). Bacopa monnieri is used in Ayurvedic traditional medicine to improve memory and to treat various ailments. The aim of the project is to achieve immediate release of drug from dosage form to achieve therapeutic efficacy and patient compliance. Hard gelatin capsules offer rapid drug release and protection from atmospheric oxygen. Materials and methods: In this work we have prepared the granules of Brahmi and filled into the empty hard gelatin capsule shells. The hard gel

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Al-Tabakha, Moawia M. "HPMC Capsules: Current Status and Future Prospects." Journal of Pharmacy & Pharmaceutical Sciences 13, no. 3 (2010): 428. http://dx.doi.org/10.18433/j3k881.

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Hydroxypropyl methylcellulose (HPMC) is employed for a wide variety of pharmaceutical and food preparations. Its applications as viscolizing agent (thickening agent), coating polymer, bioadhesive, in solid dispersion to enhance solubility, binder in the process of granulation and in modified release formulations have been well documented. One other notable use is in the production of capsule shells, replacing the animal derived gelatin in conventional two-piece capsules. The aim of this review is to systemically survey published literature on the HPMC use in capsule shells and resolve question

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Uchimura, Érica Mayumi Takase, Irene Harumi Kamata Barcelos, Deborah Brandão de Paiva, Lucia Figueiredo Mourão, and Agricio Nubiato Crespo. "Evaluation of the location of capsules swallowed with food during the pharyngeal phase triggering in asymptomatic adults." CoDAS 26, no. 6 (2014): 476–80. http://dx.doi.org/10.1590/2317-1782/20140000045.

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OBJECTIVE: To assess the location of hard gelatin capsules in the pharyngeal phase triggering among asymptomatic adults. INTRODUCTION: The location of the bolus during the pharyngeal phase triggering provides information about the sensorimotor model of the beginning of deglutition onset. PURPOSE: To evaluate the location of hard gelatin capsules in the pharyngeal phase triggering among asymptomatic adults. METHODS: A videofluoroscopy swallowing study was carried out in 60 subjects (14 male and 46 female participants) aged between 27 and 55 years, who were evaluated with hard gelatin capsules #

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Controulis, John, and Parke Davis. "Hard Gelatin Capsules – New Developments from Capsugel." Drug Development and Industrial Pharmacy 11, no. 2-3 (1985): 585–90. http://dx.doi.org/10.3109/03639048509056889.

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9

GARG, RAM, SARFARAZ ALAM, and VANDANA SHARMA. "A Review on Gelatin Production and a Special Type of Hard Gelatin Capsules With Their Packaging and Storage." Indian Journal of Health Care, Medical & Pharmacy Practice 4, no. 2 (2023): 71–78. http://dx.doi.org/10.59551/ijhmp/25832069/2023.4.2.60.

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In this review it is explained about production of gelatin and a special type of hard gelatin capsules with their packaging and storage. Capsules are solid dosage preparations that contain a soft soluble shell of gelatin that encloses the drug substance(s) and/or excipients whereas hard capsules are made up of two pieces that resemble cylinders that are closed at one end: the longer piece is called the "body," and the shorter piece is called the "cap." A variety of formulation types, the majority of which are meant for oral administration, can be filled into capsules. Special applications incl

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Majee, Sutapa Biswas, Dhruti Avlani, and Gopa Roy Biswas. "HPMC AS CAPSULE SHELL MATERIAL: PHYSICOCHEMICAL, PHARMACEUTICAL AND BIOPHARMACEUTICAL PROPERTIES." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 10 (2017): 1. http://dx.doi.org/10.22159/ijpps.2017v9i10.20707.

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The most common instability problem of gelatin capsules arises from negative impact of extremes of temperature and especially atmospheric relative humidity on the mechanical integrity of the capsule shells with adverse effect extended even to the fill material. Moreover, choice of fill materials is highly restricted either due to their specific chemical structure, physical state or hygroscopicity. Additional reports of unpredictable disintegration and dissolution of filled hard gelatin capsules in experimental studies have prompted the search for a better alternative capsule shell material. Th

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Tarman, Kustiariyah, Pipin Supinah, Erika Wahyu Dewanti, Joko Santoso, and Nurjanah Nurjanah. "Characteristics of carrageenan from seaweed hydrolysis using marine fungi as hard-shell capsule material." Jurnal Pengolahan Hasil Perikanan Indonesia 27, no. 8 (2024): 642–53. http://dx.doi.org/10.17844/jphpi.v27i8.51946.

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Carrageenan is a polysaccharide extracted from red algae and can be used as a raw material for hard-shell capsules. Carrageenan can be produced by biological hydrolysis of marine fungi. The viscosity of carrageenan resulting from hydrolysis using marine fungi is lower than that of commercial carrageenan. Gelatine can be used to modify the characteristics of polysaccharide-based materials. The characteristics and types of carrageenan and plasticizers influence the interactions between carrageenan and gelatin. This study aimed to determine the characteristics of carrageenan produced by seaweed h

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Sutanto, Hery, Wulan Sutardiman, and Silvya Yusri. "Stability Evaluation of Candlenut Oil Capsule: Disintegration, Iodine Value, Omega Content, and Drug Kinetics." Journal of Pharmaceutical Sciences and Community 20, no. 2 (2023): 130–38. http://dx.doi.org/10.24071/jpsc.004982.

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Candlenut oil, known for its high omega-3 fatty acid content (up to 90%), shows great promise as a valuable source of omega. However, its rich unsaturated fatty acid composition makes it susceptible to oxidation and quality degradation. To address this, candlenut oil is encapsulated for use as a food supplement product. This research aims to investigate the stability of omega oil content in capsulated candlenut oil as well as the physical and chemical properties of gelatin and seaweed-based hard capsules used for encapsulation. Additionally, the study explores the optimal capsule material, opa

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Kovaleva, E. L., O. A. Matveeva, V. V. Shelestova, and K. A. Balatskaya. "Pharmacopoeias’ and manufacturers’ requirements for the quality of hard gelatin capsule shells." Regulatory Research and Medicine Evaluation 14, no. 6 (2024): 620–33. https://doi.org/10.30895/1991-2919-2024-14-6-620-633.

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INTRODUCTION. The lack of national requirements regulating the quality of empty hard gelatin capsule shells (before filling with medicines) causes difficulties not only for capsule developers and manufacturers but also for experts evaluating regulatory submissions. This necessitates a comparative analysis of Russian and international requirements for the quality of hard gelatin capsule shells in order to draft a pharmacopoeia monograph on empty hard gelatin capsule shells.AIM. This study aimed to analyse the level of quality requirements for hard gelatin capsule shells, the selection of qualit

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Susanti, Tri, Siti Wafiroh, Esti Hendradi, and Pratiwi Pudjiastuti. "Characterization and release profile of sodium diclofenac halal hard shell capsules made from k-carrageenan and xanthan gum with sorbitol plasticizer." Journal of Halal Product and Research 3, no. 1 (2020): 1. http://dx.doi.org/10.20473/jhpr.vol.3-issue.1.1-8.

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Halal hard shell capsules are importantly needed by Indonesian consumers, who are predominantly Muslim, to substitute mostly used and commercially available products made from non-halal ingredients such as gelatin. The objective of this study is to prepare, characterize, and evaluate halal hard shell capsules made from k-carrageenan-xanthan gum with sorbitol as the plasticizer with diclofenac sodium as the model drug. Hardshell capsules were prepared with combinations of κ-carrageenan-xanthan gum at a weight ratio of 4:2 with the addition of 70% sorbitol, which added at a varied volume of 0.25

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Sonar, S. P., S. B. Gondkar, and R. B. Saudagar. "Formulation and Evaluation of Liquid Filled Hard Gelatin Capsule of Febuxostat." Journal of Drug Delivery and Therapeutics 9, no. 5 (2019): 105–9. http://dx.doi.org/10.22270/jddt.v9i5.3579.

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Liquid filled hard gelatin capsule are well recognized as a solid dosage form for convenient administration of drugs orally in a liquid form. This liquid composition available help the most challenging drug compounds in capsules has increased significantly in recent years. The drugs which have low solubility, poor bioavailability, low melting point, critical stability are the perfect candidate for liquid filling in capsule. The current study presents the formulation aspects, filling and sealing aspects of capsule, evaluation parameters of the liquid filled hard gelatin capsule using Febuxostat

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Y, Madhusudan Rao, Vinay Kumar K, Jagan Mohan S, and Kiran Kumar V. "Formulation and Evaluation of Extended Release Trihexyphenidyl Hydrochloride Hard Gelatin Capsules." International Journal of Pharmaceutical Sciences and Nanotechnology 4, no. 1 (2011): 1359–67. http://dx.doi.org/10.37285/ijpsn.2011.4.1.8.

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This work aims at investigating different types and levels of hydrophilic high molecular weight matrix agents, (including HPMC K15M, Metalose-60 SH, Metalose-65 SH and Metalose-90SH-SR), hydrophobic diluent (Talc) and formulation methods (Non-aqueous granulation and direct filling by simple mere mixture) in an attempt to formulate hard gelatin extended release matrix capsules containing Trihexyphenidyl HCl (Benzhexol). The drug release from all the extended release matrix capsules show polymer as well as talc concentration dependent retardation affect. The Metalose 90SH-SR concentration was op

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Rogowska, Magdalena, Karol Iwaniak, Andrzej Polski, et al. "Influence of different excipients on the properties of hard gelatin capsules with metamizole sodium." Current Issues in Pharmacy and Medical Sciences 29, no. 3 (2016): 114–17. http://dx.doi.org/10.1515/cipms-2016-0023.

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Abstract Metamizole is an effective non-opioid analgesic drug used in the treatment of acute and chronic pain. Due to induced potentially life-threatening blood disorders, metamizole was withdrawn from market in many parts of the world, however, it is one of the most popular analgesics in Poland that is available as an over the counter drug. Patients tend to prefer capsules over tablets, as they are easier to swallow and taste better. The powder-filled capsules also have greater bioavailability and require less excipients, as compared to tablets. Polymic excipients are mainly used in capsule f

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Butkevičiūtė, Aurita, Mindaugas Liaudanskas, Kristina Ramanauskienė, and Valdimaras Janulis. "Biopharmaceutical Evaluation of Capsules with Lyophilized Apple Powder." Molecules 26, no. 4 (2021): 1095. http://dx.doi.org/10.3390/molecules26041095.

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Apples are an important source of biologically active compounds. Consequently, we decided to model hard gelatin capsules with lyophilized apple powder by using different excipients and to evaluate the release kinetics of phenolic compounds. The apple slices of “Ligol” cultivar were immediately frozen in a freezer (at −35°C) with air circulation and were lyophilized with a sublimator at the pressure of 0.01 mbar (condenser temperature, −85°C). Lyophilized apple powder was used as an active substance filled into hard gelatin capsules. We conducted capsule disintegration and dissolution tests to

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Cadé, D., E. T. Cole, J. Ph Mayer, and F. Wittwer. "Liquid Filled and Sealed Hard Gelatin Capsules." Drug Development and Industrial Pharmacy 12, no. 11-13 (1986): 2289–300. http://dx.doi.org/10.3109/03639048609042636.

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Fauzi, Muhammad Al Rizqi Dharma, Pratiwi Pudjiastuti, Esti Hendradi, Riyanto Teguh Widodo, and Mohd Cairul Iqbal Mohd Amin. "Characterization, Disintegration, and Dissolution Analyses of Carrageenan-Based Hard-Shell Capsules Cross-Linked with Maltodextrin as a Potential Alternative Drug Delivery System." International Journal of Polymer Science 2020 (March 12, 2020): 1–7. http://dx.doi.org/10.1155/2020/3565931.

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Hard-shell capsules commonly consist of gelatin which is not a universal material considering it is extracted from animal parts. Moreover, the mad cow disease triggered the scrutinization of the use of gelatin in pharmaceutical products. Hence, an alternative to conventional hard-shell capsules is needed. Carrageenan- (CRG-) based hard-shell capsules were successfully prepared by cross-linking CRG with maltodextrin (MD) and plasticizing with sorbitol (SOR). These CRG-MD/SOR hard-shell capsules were produced as an alternative to conventional hard-shell capsules in the oral drug delivery system

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Isabel Hernández-González, Sandra, Jesús Iván García-Castañeda, José de Jesús Alba-Romero, Aurora Martínez-Romero, Rodolfo Gerardo Chew-Madinaveitia, and José Luis Ortega-Sanchez. "Manufacture of Hard Gelatin Capsules From a Lyophilisate of the Morus Nigra Fruit." Sumerianz Journal of Medical and Healthcare, no. 42 (June 7, 2021): 109–13. http://dx.doi.org/10.47752/sjmh.42.109.113.

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Morus nigra L. (M. nigra L.) belongs to the Moraceae family. Traditional medicine for its physicochemical properties. To evaluate the physicochemical composition and pharmaceutical stability of hard gelatin capsules of the freeze-dried fruit of M. nigra L. The content of total phenols (CFT) and antioxidant capacity (CA) were evaluated by spectrophotometry, the content of ash, moisture, protein, fat and fiber were determined according to their own standard. The CFT and CA were 25.4 mg gallic acid equivalents/g of sample, and 74.1% inhibition, respectively. On the other hand, the values of ash,

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Bonino, Marine, Amélie Bouchez, Amna Kadri, et al. "Thiamine hydrochloride, riboflavin, pyridoxine hydrochloride, and biotin hard gelatin capsules prepared in advance and stored for the treatment of pediatric metabolic diseases: a safer alternative." PLOS One 20, no. 4 (2025): e0321136. https://doi.org/10.1371/journal.pone.0321136.

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The treatment of several pediatric metabolic diseases involves vitamins supplementation. Among these, thiamine, riboflavin, pyridoxine and biotin can be prescribed and compounded as hard gelatin capsules. In compounding practice, a medication can be done extemporaneously, leading to a risk of error. However, a medication can also be done in advance, analytically controlled and stored. Such practice reduce the risk of error and decrease the cost, but also imposes the realization of stability studies to establish beyond-use-dates. Thiamine hydrochloride, riboflavin, pyridoxine hydrochloride, and

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ABARNA P, MITHUN BALA D, SARAL S, et al. "Design, development, formulation and evaluation of hard gelatin aspirin capsule." World Journal of Biology Pharmacy and Health Sciences 21, no. 3 (2025): 319–25. https://doi.org/10.30574/wjbphs.2025.21.3.0252.

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Immediate-release Aspirin capsules are widely used for the treatment of pain, fever, and inflammation, and for the prevention of cardiovascular events. This study focuses on the formulation, development, and evaluation of immediate-release Aspirin capsules. The primary aim is to design a formulation that ensures rapid disintegration and dissolution, providing quick therapeutic effects. The capsules are prepared using a blend of active pharmaceutical ingredients (Aspirin) and excipients, including starch, lactose, and talc, utilizing a hand-filling method. The stability, dissolution, disintegra

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Raihan, Roshaan, Azimullah Wafa, Aqa Mohammad Zhakfar, and Sudhakar CK. "Oral Disintegrating Films: A Review." Journal of Natural Science Review 2, no. 2 (2024): 60–74. http://dx.doi.org/10.62810/jnsr.v2i2.42.

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The oral route stands out as a preferred method for drug administration due to its cost-effectiveness and ease, contributing to enhanced patient compliance. Some individuals, particularly the geriatric and pediatric populations, encounter difficulties swallowing conventional tablets and hard gelatin capsules. To address this, oral disintegrating drug delivery systems are established as substitutes for tablets, capsules, and syrups. Notably, fast-dissolving oral thin films offer a practical solution for patients such as those in pediatric, bedridden, or developmentally disabled categories, as w

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Gupta, Rajkumar. "STEPS FOR SUCCESS IN SOURCING OF HARD GELATIN CAPSULES FOR PHARMACEUTICAL USE." International Journal of Drug Regulatory Affairs 2, no. 1 (2018): 32–36. http://dx.doi.org/10.22270/ijdra.v2i1.123.

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The sourcing of raw Gelatin for manufacturing hard Gelatin Capsules is a very critical function. It involves a thorough quality audit of the suppliers. The most critical audit points are: source of Gelatin used, quality control and quality assurance procedures, packaging system and storage conditions. In addition to these the facility shall be checked for domestic and international quality certifications and advance quality features.

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Barakat, Abdullah, Yahya Abu-Hameda, Salah Aljamal, et al. "Formulation and evaluation of controlled-release, carrageenan-based powder formulations filled into hard gelatin capsules." Jordan Journal of Pharmaceutical Sciences 16, no. 2 (2023): 474. http://dx.doi.org/10.35516/jjps.v16i2.1531.

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Hard gelatin capsules (HGCs) are typically used as immediate release dosage forms, however, controlled drug release can from HGCs be obtained by the application of film coating onto the capsule shells or by filling them with controlled release multi-particulates (e.g. pellets and mini-tablets). The filling of a hydrophilic gelling polymer into the capsule is an alternative approach to the time-consuming preparation and filling of multi-particulates. Carrageenan is a linear, sulfated polysaccharide that is commonly used as a thickener in pharmaceutical formulations. The release beha

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Vlachou, Marilena, Stefanos Kikionis, Angeliki Siamidi, et al. "Fabrication and Characterization of Electrospun Nanofibers for the Modified Release of the Chronobiotic Hormone Melatonin." Current Drug Delivery 16, no. 1 (2018): 79–85. http://dx.doi.org/10.2174/1567201815666180914095701.

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Objective: Aiming at the modified release of melatonin (MLT), electrospun-MLT loaded nanofibers, filled into hard gelatin and DRcapsTM capsules, were used as formulants. Methods: Cellulose acetate, polyvinylpyrrolidinone and hydroxypropylmethylcellusose (HPMC 2910) were used for the preparation of the fiber matrices through electrospinning. The in vitro modified release profile of MLT from the fabricated matrices in gastrointestinal-like fluids was studied. At pH 1.2, the formulations CA1, CA2, PV1, HP1, HP2 and the composite formulations CAPV1-CAPV5 in hard gelatin capsules exhibited fast MLT

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Dessy N Siahaan, Ririyen, Hakim Bangun, and Sumaiyah Sumaiyah. "IN VITRO AND IN VIVO EVALUATION OF FLOATING GASTRORETENTIVE DRUG DELIVERY SYSTEM OF CIMETIDINE USING HARD ALGINATE CAPSULES." Asian Journal of Pharmaceutical and Clinical Research 11, no. 6 (2018): 162. http://dx.doi.org/10.22159/ajpcr.2018.v11i6.24731.

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Objective: The objective of this study was to evaluate in vitro and in vivo of gastroretentive drug delivery system of cimetidine using hard alginate capsules.Methods: Drug release study was tested to various hard alginate capsules containing 200 mg cimetidine with paddle method dissolution apparatus in artificial gastric fluid pH 1.2. Concentrations of cimetidine were measured using ultraviolet spectrophotometer at 218.4 nm wavelength. The product that fulfilled the sustained release profile was evaluated for bioavailability using male rabbits at dose 9.3 mg/kg orally, and the antiulcer studi

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SMITH, A., J. LAMPARD, K. CARRUTHERS, and P. REGAN. "The filling of molten ibuprofen into hard gelatin capsules." International Journal of Pharmaceutics 59, no. 2 (1990): 115–19. http://dx.doi.org/10.1016/0378-5173(90)90085-i.

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Caviglioli, Gabriele, Brunella Parodi, Valeria Posocco, Sergio Cafaggi, and Gaetano Bignardi. "Stability Study of Hard Gelatin Capsules Containing Retinoic Acid." Drug Development and Industrial Pharmacy 26, no. 9 (2000): 995–1001. http://dx.doi.org/10.1081/ddc-100101328.

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Sadler, Brian M., Cynthia D. Hanson, Gregory E. Chittick, William T. Symonds, and Neil S. Roskell. "Safety and Pharmacokinetics of Amprenavir (141W94), a Human Immunodeficiency Virus (HIV) Type 1 Protease Inhibitor, following Oral Administration of Single Doses to HIV-Infected Adults." Antimicrobial Agents and Chemotherapy 43, no. 7 (1999): 1686–92. http://dx.doi.org/10.1128/aac.43.7.1686.

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ABSTRACT We conducted a double-blind, placebo-controlled, parallel, dose-escalation trial to evaluate the pharmacokinetics and safety of single, oral doses of amprenavir (141W94; formerly VX-478), a potent inhibitor of human immunodeficiency virus (HIV) type 1 protease, administered as hard gelatin capsules in 12 HIV-infected subjects. The doses of amprenavir evaluated were 150, 300, 600, 900, and 1,200 mg. Amprenavir was rapidly absorbed, with the time to maximum concentration occurring within 1 to 2 h after dosing. On the basis of power model analysis, the increase in the maximum concentrati

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Pina, M. "Enteric coating of hard gelatin capsules. Part 2 — Lioavailability of formaldehyde treated capsules." International Journal of Pharmaceutics 148, no. 1 (1997): 73–84. http://dx.doi.org/10.1016/s0378-5173(96)04824-7.

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Mahardika, Micha, Fauzan Amin, Ika Agustia Umami, Boima Situmeang, and Agus Malik Ibrahim. "Synthesis and characterization of capsule shells non gelatin grass jelly leaves-seaweed as drug delivery system material." Jurnal Pendidikan Kimia 13, no. 1 (2021): 1–9. http://dx.doi.org/10.24114/jpkim.v13i1.24138.

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Drug delivery system is a system that describes the journey of a drug to its target location. The main component of the drug delivery system is gelatin. The leaves of grass jelly-seaweed are needed as a raw material for gelatin. The main component of gelling agents in grass jelly leaves and seaweed is a low-methoxy pectin polysaccharide. Pectin from previous study is used as a synthesis material for hard capsule shells with the addition of other ingredients, which are Na-CMC, sorbitol, and water. The characterization results of capsule shells with variations in the composition of grass jelly-s

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Thevin, Patrick, Christophe Curti, Alexandre Benech, et al. "Low-dose erythromycin in pediatrics: Formulation and stability of 20 mg hard gelatin capsules." PLOS ONE 18, no. 2 (2023): e0282164. http://dx.doi.org/10.1371/journal.pone.0282164.

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Objective Erythromycin is a macrolide antibiotic that is also prescribed off-label in premature neonates as a prokinetic agent. There is no oral formulation with dosage and/or excipients adapted for these high-risk patients. Methods Clinical studies of erythromycin as a prokinetic agent were reviewed. Capsules of 20 milligrams of erythromycin were compounded with microcrystalline cellulose. Erythromycin capsules were analyzed using the chromatographic method described in the United States Pharmacopoeia which was found to be stability-indicating. The stability of 20 mg erythromycin capsules sto

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Kruk, Katarzyna, and Katarzyna Winnicka. "Hard Gelatin Capsules with Alginate-Hypromellose Microparticles as a Multicompartment Drug Delivery System for Sustained Posaconazole Release." International Journal of Molecular Sciences 25, no. 13 (2024): 7116. http://dx.doi.org/10.3390/ijms25137116.

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Microparticles as a multicompartment drug delivery system are beneficial for poorly soluble drugs. Mucoadhesive polymers applied in microparticle technology prolong the contact of the drug with the mucosa surface enhancing drug bioavailability and extending drug activity. Sodium alginate (ALG) and hydroxypropyl methylcellulose (hypromellose, HPMC) are polymers of a natural or semi-synthetic origin, respectively. They are characterized by mucoadhesive properties and are applied in microparticle technology. Spray drying is a technology employed in microparticle preparation, consisting of the ato

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Prasad, V. Deva. "Formulation and modifying drug release from Hard and Soft Gelatin Capsules for Oral drug delivery." International Journal of Research and Development in Pharmacy & Life Sciences 06, no. 04 (2017): 2663–77. http://dx.doi.org/10.21276/ijrdpl.2278-0238.2017.6(4).2663-2677.

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Slipchenko, G. D. "Determination of the critical parameters of the technological process of obtaining solid dosage forms with dry extract and crushed roots and rootes of Scutellaria baicalensis." Farmatsevtychnyi zhurnal, no. 3 (July 1, 2019): 56–64. http://dx.doi.org/10.32352/0367-3057.3.19.07.

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An important condition for obtaining a high-quality drug is the determination of critical points and parameters of the production process, which is divided into several successive stages. The aim study of the critical parameters of the production of tablets and capsules with vegetable raw materials. For this purpose, validation studies of technological processes were carried out for tablets with dry extract of Scutellaria baicalensis and hard gelatin capsules with vegetable raw materials. The subject of our research was the technological process of obtaining tablets based on dry ex

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Салій, О. О., О. В. Лось, О. П. Баула, and В. Ю. Турчина. "Development of composition and evaluation of equivalence of diacerein hard gelatin capsules." Farmatsevtychnyi zhurnal, no. 6 (December 20, 2021): 62–72. http://dx.doi.org/10.32352/0367-3057.6.21.06.

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Diacerein is a new generation of symptomatic slow-acting agent for the treatment of osteoarthritis, when taken orally, it exhibits moderate anti-inflammatory and analgesic activity, slows down the decay of cartilage tissue and relieves pain and swelling, but its physicochemical properties it is practically insoluble in water, due to which only 35‒56% the drug reaches systemic circulation. Therefore, the search for approaches to increase the dissolution rate of a practically insoluble API using the formulation, type of excipients, degree of solubility and kinetics of the substance release from

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&NA;. "Saquinavir: soft and hard gelatin capsules have similar safety profile." Reactions Weekly &NA;, no. 841 (2001): 2. http://dx.doi.org/10.2165/00128415-200108410-00002.

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Weigert, Graziella Gonçalves, Aniéle Posser Ineu, and Patrícia Gomes. "Evaluation of hard gelatin capsules and hydroxypropyl methylcellulose containing ampicillin." Química Nova 35, no. 2 (2012): 286–90. http://dx.doi.org/10.1590/s0100-40422012000200010.

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Botzolakis, John E., and Larry L. Augsburger. "Disintegrating Agents in Hard Gelatin Capsules. Part II: Swelling Efficiency." Drug Development and Industrial Pharmacy 14, no. 9 (1988): 1235–48. http://dx.doi.org/10.3109/03639048809151931.

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Saim, Said, and Stephen T. Horhota. "Process for Overcoming Drug Retention in Hard Gelatin Inhalation Capsules." Drug Development and Industrial Pharmacy 28, no. 6 (2002): 641–54. http://dx.doi.org/10.1081/ddc-120003855.

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Салій, О. О., Г. Г. Куришко, З. О. Огеренко та О. В. Гетало. "ПОРІВНЯЛЬНІ ДОСЛІДЖЕННЯ ПРОФІЛІВ ВИВІЛЬНЕННЯ ДОКСИЦИКЛІНУ ХІКЛАТУ З ТВЕРДИХ ЖЕЛАТИНОВИХ КАПСУЛ ПРИ ЗМІНІ ВИРОБНИКІВ ДІЮЧОЇ РЕЧОВИНИ". Bulletin of the Kyiv National University of Technologies and Design. Technical Science Series 146, № 3 (2021): 165–74. http://dx.doi.org/10.30857/1813-6796.2020.3.14.

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Comparative studies of the release profiles of doxycycline hyclate from hard gelatine capsules, developed with the active ingredient of alternative manufacturers. The object of the study is samples of the drug doxycycline hyclate in the form of hard gelatin capsules made from an API of an approved manufacturer "Kaifeng Pharmaceutical Group Co. Ltd", China and an alternative manufacturer "HebeiJiupeng Pharmaceutical Co., Ltd.", China. The study of the profiles of the release of the active substance from the drug was carried out using the "Paddle apparatus". The amount of the released substance

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Салій, О. О., Г. Г. Куришко, З. О. Огеренко та О. В. Гетало. "ПОРІВНЯЛЬНІ ДОСЛІДЖЕННЯ ПРОФІЛІВ ВИВІЛЬНЕННЯ ДОКСИЦИКЛІНУ ХІКЛАТУ З ТВЕРДИХ ЖЕЛАТИНОВИХ КАПСУЛ ПРИ ЗМІНІ ВИРОБНИКІВ ДІЮЧОЇ РЕЧОВИНИ". Bulletin of the Kyiv National University of Technologies and Design. Technical Science Series 146, № 3 (2021): 165–74. http://dx.doi.org/10.30857/1813-6796.2020.3.14.

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Comparative studies of the release profiles of doxycycline hyclate from hard gelatine capsules, developed with the active ingredient of alternative manufacturers. The object of the study is samples of the drug doxycycline hyclate in the form of hard gelatin capsules made from an API of an approved manufacturer "Kaifeng Pharmaceutical Group Co. Ltd", China and an alternative manufacturer "HebeiJiupeng Pharmaceutical Co., Ltd.", China. The study of the profiles of the release of the active substance from the drug was carried out using the "Paddle apparatus". The amount of the released substance

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Dewan, Irin, Ananta Saha, SM Ashraful Islam, Mahjabeen Gazi, Tasnuva Amin, and Sayeeda Fahmee Chowdhury. "Study and Evaluation of Release Kinetics of Tramadol HCl from Lipid Based Sustained Release Capsules by Melt Matrix." Dhaka University Journal of Pharmaceutical Sciences 11, no. 2 (2013): 137–45. http://dx.doi.org/10.3329/dujps.v11i2.14572.

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The aim of our study was to improve the dissolution of Tramadol hydrochloride (TH) via its semisolid filled lipid based capsules. Sustained release formulation is designed to achieve a prolonged therapeutic effect by continuously releasing medication over an extended period of time after administration of single dose. Semisolid matrixes of TH were prepared by melt-matrix method and were filled in hard gelatin capsule shell (size 0). In this experiment, a mixture of Glycerol monostearate (GMS) and lipid materials like different lipophilic oils and surfactants were used to improve the matrix int

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Liliia, Vyshnevska, Bysaga Elizaveta, and Soldatov Dmytro. "Pharmacotechnological studies of model samples in the development of a composition of solid gastrosoluble capsules." ScienceRise: Pharmaceutical Science, no. 1(17) (February 28, 2019): 45–48. https://doi.org/10.15587/2519-4852.2019.158618.

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<strong>Aim</strong>: the aim of our work was to experimentally substantiate the choice of auxiliary substances in the development of the composition of solid gastro-soluble capsules for the treatment of diseases of the gastrointestinal tract <strong>Methods:</strong> pharmacotechnological research methods were used <strong>Results.</strong> Conducted research on the development of the composition and technology of hard gelatin gastro-soluble capsules with a dry extract under the conventional name urocholum. The effect of a number of auxiliary substances and dry extract on the pharma

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Naik, S. B. Thirumalesh, M. Purushothaman, and K. B. Chandrasekhar. "Fabrication and Evaluation of Mini Tablet Filled Capsules to Treat Transient Ischemic Attack." Asian Journal of Chemistry 33, no. 1 (2020): 89–96. http://dx.doi.org/10.14233/ajchem.2021.22929.

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In this work, mini tablets filled hard gelatin capsules were fabricated for a fixed-dose therapy for transient ischemic attack (TIA). Clopidogrel besylate (CB)-75 mg and acetyl salicylic acid (ASA)-75 mg were utilized in this work. Among the mini-tablets (MTs) clopidogrel besylate, was uncoated conventional mini-tablets, whereas acetyl salicylic acid was enteric-coated. Acetyl salicylic acid gastric irritation was overcome by using Plantago ovata seed mucilage as a binder in all mini-tablets. Both types of mini-tablets were filled in hard gelatin capsules. Clopidogrel besylate and acetyl salic

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Gammel, I. V., and S. А. Gorbunova. "The study of the range of drugs in hard gelatin capsules." Medical almanac, no. 1 (2018): 121–25. http://dx.doi.org/10.21145/2499-9954-2018-1-121-125.

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Hashem, Fahima M., Ahmad M. A. Massoud, Abdullah M. Melokheya, Hazem Emad, Kamal Abd El-Fattah Badr, and Mohamed Dawoud. "Formulation and Clinical Efficacy of Myrrh Extract in Hard Gelatin Capsules." Journal of Biologically Active Products from Nature 3, no. 1 (2013): 72–86. http://dx.doi.org/10.1080/22311866.2013.782763.

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Howard, J. R., and P. L. Gould. "Drug Release from Thermosetting Fatty Vehicles Filled into Hard Gelatin Capsules." Drug Development and Industrial Pharmacy 13, no. 6 (1987): 1031–45. http://dx.doi.org/10.3109/03639048709068368.

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