Academic literature on the topic 'Harris criterion'
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Journal articles on the topic "Harris criterion"
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Brooks, Harris A. "The ‘Harris criterion’ lives on." Journal of Physics: Condensed Matter 28, no. 42 (2016): 421006. http://dx.doi.org/10.1088/0953-8984/28/42/421006.
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Derrida, B., H. Dickinson, and J. Yeomans. "On the Harris criterion for hierarchical lattices." Journal of Physics A: Mathematical and General 18, no. 1 (1985): L53—L55. http://dx.doi.org/10.1088/0305-4470/18/1/010.
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Berker, A. Nihat. "Harris criterion for direct and orthogonal quenched randomness." Physical Review B 42, no. 13 (1990): 8640–42. http://dx.doi.org/10.1103/physrevb.42.8640.
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Weichman, Peter B., and Michael E. Fisher. "Helium in Vycor, constrained randomness, and the Harris criterion." Physical Review B 34, no. 11 (1986): 7652–65. http://dx.doi.org/10.1103/physrevb.34.7652.
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Ghosh, A. K., та A. N. Basu. "Harris Criterion in α-irradiated (Bi,Pb)-2223 Superconductor". Physica Scripta 59, № 5 (1999): 402–4. http://dx.doi.org/10.1238/physica.regular.059a00402.
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Angerer, Wolfgang P. "New Limiting Distributions for Bellman-Harris Processes." Journal of Applied Probability 48, no. 02 (2011): 313–21. http://dx.doi.org/10.1017/s0021900200007890.
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We present a number of new solutions to an integral equation arising in the limiting theory of Bellman-Harris processes. The argument proceeds via straightforward analysis of Mellin transforms. We also derive a criterion for the analyticity of the Laplace transform of the limiting distribution on Re(u) ≥ -c for some c > 0.
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Angerer, Wolfgang P. "New Limiting Distributions for Bellman-Harris Processes." Journal of Applied Probability 48, no. 2 (2011): 313–21. http://dx.doi.org/10.1239/jap/1308662629.
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We present a number of new solutions to an integral equation arising in the limiting theory of Bellman-Harris processes. The argument proceeds via straightforward analysis of Mellin transforms. We also derive a criterion for the analyticity of the Laplace transform of the limiting distribution on Re(u) ≥ -c for some c > 0.
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Chen, Anyue, Junping Li, and N. I. Ramesh. "General Harris regularity criterion for non-linear Markov branching processes." Statistics & Probability Letters 76, no. 5 (2006): 446–52. http://dx.doi.org/10.1016/j.spl.2005.08.014.
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Cruz, H. R. da, and R. B. Stinchcombe. "On the violation of the Harris criterion by RSRG methods." Journal of Physics C: Solid State Physics 19, no. 19 (1986): 3555–69. http://dx.doi.org/10.1088/0022-3719/19/19/012.
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Mukherji, Sutapa, and Somendra M. Bhattacharjee. "Failure of the Harris criterion for directed polymers on hierarchical lattices." Physical Review E 52, no. 2 (1995): 1930–33. http://dx.doi.org/10.1103/physreve.52.1930.
Full textDissertations / Theses on the topic "Harris criterion"
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Berger, Quentin. "Polymères en milieu aléatoire : influence d'un désordre corrélé sur le phénomène de localisation." Phd thesis, Ecole normale supérieure de lyon - ENS LYON, 2012. http://tel.archives-ouvertes.fr/tel-00726494.
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Cette thèse porte sur l'étude de modèles de polymère en milieu aléatoire: on se concentre sur le cas d'un polymère dirigé en dimension d+1 qui interagit avec un défaut unidimensionnel. Les interactions sont possiblement non-homogènes, et sont représentées par des variables aléatoires. Une question importante est celle de l'influence du désordre sur le phénomène de localisation: on veut déterminer si la présence d'inhomogénéités modifie les propriétés critiques du système, et notamment les caractéristiques de la transition de phase (auquel cas le désodre est dit pertinent). En particulier, nous prouvons que dans le cas où le défaut est une marche aléatoire, le désordre est pertinent en dimension d≥3. Ensuite, nous étudions le modèle d'accrochage sur une ligne de défauts possédant des inhomogénéités corrélées spatialement. Il existe un critère non rigoureux (dû à Weinrib et Halperin), que l'on applique à notre modèle, et qui prédit si le désordre est pertinent ou non en fonction de l'exposant critique du système homogène, noté νpur, et de l'exposant de décroissance des corrélations. Si le désordre est gaussien et les corrélations sommables, nous montrons la validité du critère de Weinrib-Halperin: nous le prouvons dans la version hiérarchique du modèle, et aussi, de manière partielle, dans le cadre (standard) non-hiérarchique. Nous avons de plus obtenu un résultat surprenant: lorsque les corrélations sont suffisamment fortes, et en particulier si elles sont non-sommables (dans le cadre gaussien), il apparaît un régime où le désordre devient toujours pertinent, l'ordre de la transition de phase étant toujours plus grand que νpur. La prédiction de Weinrib-Halperin ne s'applique alors pas à notre modèle.
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Poisat, Julien. "Modèle d’accrochage de polymères en environnement aléatoire faiblement corrélé." Thesis, Lyon 1, 2012. http://www.theses.fr/2012LYO10056/document.
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Cette thèse est consacrée à l’étude du modèle d’accrochage en environnementfaiblement corrélé. Le modèle d’accrochage s’applique à de multiples situationstelles que la localisation d’un polymère au voisinage d’une interface unidimensionnelle,la transition de mouillage ou encore la dénaturation de l’ADN, le pointcommun étant la présence d’une transition entre une phase localisée et une phasedélocalisée.Nous commençons par donner un aperçu des résultats disponibles sur lescourbes et exposants critiques pour le modèle homogène puis pour le modèledésordonné lorsque le désordre est une suite de variables aléatoires indépendanteset identiquement distribuées (i.i.d.). Dans ce dernier cas, nous donnons égalementune borne sur la courbe critique quenched à haute température, dans un régimeoù le désordre est dit pertinent.Nous étudions ensuite le modèle d’accrochage désordonné dans le cas où ledésordre est gaussien et les corrélations ont une portée finie, à l’aide de la théoriedes processus de renouvellement markoviens. Nous donnons dans ce cas une expressionde la courbe annealed à l’aide de la plus grande valeur propre d’une matricede transfert ainsi que l’exposant critique annealed. Nous généralisons ensuite lescritères de pertinence et de non pertinence du désordre prouvés dans le cas i.i.d.Nous nous intéressons ensuite à des désordres dont les corrélations ont uneportée de corrélation infinie. Dans un premier temps, nous généralisons la démarcheutilisée dans le cas d’une portée de corrélations finie et obtenons le comportementcritique annealed dans le cas d’un désordre gaussien sous des hypothèses dedécroissance forte des corrélations. Nous utilisons pour cela les propriétés spectralesdes opérateurs de transfert pour des décalages sur des suites d’entiers etdes potentiels à variations sommables. Dans un deuxième temps, nous donnonsquelques résultats dans le cas où le désordre est donné par une chaîne de Markov<br>In this dissertation we study the pinning model with weakly correlated disorder.The pinning model applies to various situations such as localization of a polymernear a one-dimensional interface, wetting transition and DNA denaturation, whichall display a transition between a localized phase and a delocalized phase.We start by giving a survey of the available results concerning critical pointsand exponents, first for the homogeneous setup and then for the inhomogeneousone, in the case when disorder is given by a sequence of independent and identicallydistributed (i.i.d.) random variables. In the latter case, we also provide a hightemperaturebound on the quenched critical curve in a case of relevant disorder.We then study the random pinning model when disorder is gaussian and hascorrelations with finite range, using the theory of Markov renewal processes. Weexpress the annealed critical curve in terms of the largest eigenvalue of a transfermatrix and we give the annealed critical exponent. We then generalize the criteriafor disorder relevance/irrelevance that were proved for the i.i.d. case.Next we are interested in disorder sequences with infinite range correlations.At first we generalize the method used to deal with finite range correlations andobtain the annealed critical behaviour in the case of gaussian disorder assumingfast decay of correlations. We use to this end the spectral properties of transferoperators for shifts on integer sequences and potentials with summable variations.Secondly we provide some results when disorder is a Markov chain
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Joshi, Bhagyashri Bharat. "Prediction of Unit Value of Un-Improved Parcels of Harris County, Texas Using LEED Sustainable Sites Criteria of Public Transportation Access." 2009. http://hdl.handle.net/1969.1/ETD-TAMU-2009-12-7595.
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Leadership in Energy and Environmental Design (LEED) is one of the environmental assessment tools available to gauge buildings. This rating system is a voluntary system which does not include financial aspects in the evaluation framework. This poses a challenge for encouraging land development projects, since developers consider financial or economic return as a crucial factor before building a project. It becomes essential to know if market really accepts the economic worth of LEED ratings. This research attempted to find out relationship between economic worth of a land and parameters (measurements), which are essential to earn LEED sustainable rating for public transportation access. To find out this relationship and to recognize power of the LEED measurements to predict the appraised value of a land (dollars per square foot) various statistical models were used and predictive equations produced.
The observational units were properties in Harris County, Texas that were unimproved and had zero improvement value. The dependent variable was unit value of the property measured in dollars per square foot. The independent variables were measurements that are required for a parcel to earn LEED sustainable site rating for public transportation access and the area of parcel.
Data regarding appraised values and land area were acquired from the Harris County Appraisal District and transportation data was obtained from Houston- Galveston Area Council.
Multiple regression analysis was used to analyze different models and to develop predictive equations.
Findings suggest that LEED green building rating system influences the appraised value, dollars per square foot, of properties. It further implies that market considers the economic effect of the LEED rating system even if this assessment method does not explicitly include financial aspects in the evaluation framework.
Findings of this research also suggest that a sustainable feature of a site is related to the economic worth of a related land development project. This will provide encouragement for new sustainable land development projects. This will provide an economic incentive to the owners and developers. Developers will get encouragement to select a site located closer to mass transit networks.
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Harris, Teresa. "A critical analysis of iron status indicators in three independent studies of South African primary school children / Teresa Harris." Thesis, 2014. http://hdl.handle.net/10394/15282.
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Background
The potential dire consequences of iron deficiency (ID) and iron deficiency anaemia (IDA) on childhood development are of major public health concern. Many factors contribute to anaemia, ID being only one progressive factor. The prevalence of ID and IDA must be accurately determined before iron intervention strategies can be safely prescribed. There is continued uncertainty regarding the optimal approach to identifying and measuring ID, as indicators have different roles, explore different aspects of iron metabolism and cannot be directly compared. Furthermore, inflammation and infection have a confounding effect on the commonly applied indicator and acute phase reactant, serum ferritin (SF). In the public health setting, a suitable method to assess iron status in developing countries has to be inexpensive, standardised, established, easy to measure and its applications specific to identifying ID.
Aim
We conducted secondary analysis of screening data from three independent iron intervention studies to critically evaluate the indicators used to determine iron status in 6-11-year-old primary school children from three South African provinces.
Study design and methods
A cross-sectional descriptive analysis was performed on the screening data collected in 2009 and 2010 during iron intervention studies in KwaZulu-Natal (n=736), Northern Cape (n= 1045), and North West (n=546). The three distinct study sites were analysed independently and collectively.
Children’s haemoglobin (Hb), SF, transferrin receptor (TfR), zinc protoporphyrin (ZPP), and C-reactive protein (CRP) concentrations were measured and body iron calculated. ID prevalence was compared using different methods (namely the single indicators SF, TfR and ZPP, body iron and the multiple criteria model), and the influence of inflammation on SF was considered. Literature suggests that the multiple criteria model provides a more complete assessment of iron status. The performance of single and body iron indicators were compared to the multiple criteria model (by assessing sensitivity, specificity and predictive values).
Results
Significant positive correlations between CRP (indicator of inflammation) and SF existed in all study sites and the combined sample (p < 0.01). The mean SF concentration was substantially
higher in subjects with inflammation than those without. A different SF cut-off to identify ID was applied to subjects with inflammation.
The percentage of ID subjects varied using different indicators (4.2 – 26.5% in KwaZulu-Natal; 4.1 – 13.4% in Northern Cape; 7.0 – 24.4% in North West; and 5.4 – 15.2% in the combined sample). The sensitivity, specificity and predictive values of alternate ID indicators varied within and between study sites, compared to the multiple criteria model.
Conclusion
Simply using Hb as an ID indicator is inaccurate. The vast differences between percentages identified as ID by different indicators is reason for concern. No consistent agreement appeared between single ID indicators, body iron and the multiple criteria model for ID identification after correcting for inflammation in primary school children. The global view of the multiple criteria model as the gold standard for estimating ID is debatable and potentially impractical at a public health level. Current evidence cautions against overestimating the prevalence of ID, as there is more associated harm than deficiency underestimation. This critical analysis has confirmed a need for research to identify a suitable, accurate and precise alternative to Hb as a tool in the South African public health setting. Furthermore, the impact of inflammation on iron status indicators, in particular SF, should be assessed in context to clearly set parameters for its use in nationally-representative nutrition surveys, the cornerstone of iron intervention strategies.<br>MSc (Nutrition), North-West University, Potchefstroom Campus, 2015
Books on the topic "Harris criterion"
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Croswell, Jennifer M., Russell P. Harris, and Barnett S. Kramer. Cancer Screening. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190238667.003.0063.
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Screening has long been portrayed as an inherently beneficial activity that saves lives, rather than as a complex mixture of potential benefits and harms that must be carefully weighed for each modality. The early success of the Pap smear in reducing deaths from cervical cancer may have inadvertently fostered simplistic messaging about unqualified benefits of screening. Over time, large-scale randomized controlled trials (RCTs) of prostate and other cancers have highlighted the potential harms caused by mass screening programs (especially those related to overdiagnosis and unnecessary treatment) and have revealed the counterintuitive elements involved in evaluating such programs. The criteria for evaluation now extend beyond the performance criteria of the test itself to include the net balance of benefits, risks, and costs. PSA screening, widely used in the United States since the late 1980s, has now been removed from the list of routinely recommended procedures, based on evidence from RCTs.
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Fassin, Didier. What Is Punishment? Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190888589.003.0003.
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What is punishment? To answer this question, two options are possible: one normative, the other critical. Ethnographic research puts H. L. A. Hart’s classical definition of punishment to the test, while taking seriously his generally overlooked remark that there should be no “definitional stop,” which ignores the complexity of practice because of a theoretical principle. After thorough examination of the five criteria provided to characterize punishment, only one seems to remain: the infliction of pain. A further genealogical exploration combining philology, ethnology, and history then shows how the response to offenses has evolved from an affective economy of debt implying reparation to a moral economy of punishment involving suffering.
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Szmukler, George. The conventional grounds for involuntary treatment are highly problematic. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198801047.003.0003.
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Substantial problems attach to both of the fundamental criteria that need to be met for involuntary treatment in conventional mental health legislation—the presence of a ‘mental disorder’ and a risk of harm to self or others. The boundaries of ‘mental disorder’ are of necessity loosely drawn, with substantial blurring at the edges and contested views about where these should lie. ‘Values’—for example, when does ‘sadness’ become a ‘depressive illness’—play a significant role in determining when a diagnosis of a ‘disorder’ is warranted. Precision in the assessment of ‘risk’ is poor, especially for those infrequent or rare harms that we are most concerned to prevent. In general psychiatric practice, the prediction of suicide or serious acts of violence to others is of severely limited value. Even with ‘state-of-the-art’ risk assessment measures, ‘false positives’ overwhelm ‘true positives’. Significant costs attach to an emphasis on risk assessment.
Book chapters on the topic "Harris criterion"
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Van Rooy, Raf. "Mutual intelligibility." In Language or Dialect? Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780198845713.003.0020.
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Chapter 20 treats the success of the criterion of mutual intelligibility since the 1950s, when American linguists interested in Amerindian tongues started to actively test this feature. Pioneers were Carl Voegelin and Zellig Harris, who suggested four methods for answering language / dialect questions, including mutual intelligibility testing. Even though scholars immediately faced numerous problems, the method enjoyed considerable success and is the primary criterion used by language catalogues such as Ethnologue and Glottolog. The criterion was criticized by, among others, Frederick Agard, who proposed nine postulates for determining language / dialect status. Others followed Morris Swadesh’s lexicostatistic lead and tried to quantify the distances between speech forms. According to one of the most recent representatives of this strand, linguistic distance is bimodally distributed, and the language / dialect distinction is, by consequence, backed by the majority of the linguistic evidence. Rather artificially, a strict cut-off point is proposed in this recent contribution.
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Harris-Fain, Darren. "Neil Gaiman and the Multifarious Approach to the Superhero." In The Artistry of Neil Gaiman. University Press of Mississippi, 2019. http://dx.doi.org/10.14325/mississippi/9781496821645.003.0004.
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In this chapter, Darren Harris-Fain offers a structuralist examination of the comics career of Neil Gaiman. Overseeing a longitudinal analysis of his work in the medium, Harris-Fain separates Gaiman's work into five distinct criteria: 1) the straightforward/direct; 2) the oblique/indirect; 3) the revisionist; 4) the comic; and 5) the mythic. While not mutually exclusive, they do, for the first time, offer clear connections between his works for all companies while distinguishing his career as it developed over the years.
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Harris, Carmen V. "Still Eating in the Kitchen." In Written/Unwritten. University of North Carolina Press, 2016. http://dx.doi.org/10.5149/northcarolina/9781469627717.003.0010.
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With an essay that challenges the notion that processes can ever be neutral, Carmen Harris addresses the issue of bureaucratic racism and the resultant marginalization of African American faculty in historically white colleges and universities through processes of faculty governance. The essay illuminates the consequences of tribalism and bias masquerading under the guise of professional objectivity in an environment in which overt racism is frowned upon but also one in which systems intended to thwart inequality are applied by members of the majority to the disadvantage of people of color. These purportedly neutral practices are a barrier to entry to an institution and manages opportunities not just for existing faculty but for potential new hires by establishing criteria and procedures for recruitment, hiring, advancing and terminating members.
Conference papers on the topic "Harris criterion"
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Bruce, Neil D. B., and Pierre Kornprobst. "Harris corners in the real world: A principled selection criterion for interest points based on ecological statistics." In 2009 IEEE Computer Society Conference on Computer Vision and Pattern Recognition Workshops (CVPR Workshops). IEEE, 2009. http://dx.doi.org/10.1109/cvpr.2009.5206494.
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Bruce, N. D. B., and P. Kornprobst. "Harris corners in the real world: A principled selection criterion for interest points based on ecological statistics." In 2009 IEEE Conference on Computer Vision and Pattern Recognition (CVPR). IEEE, 2009. http://dx.doi.org/10.1109/cvprw.2009.5206494.
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Cretu, S., and M. Benchea. "Analysis of Residual Stresses Impact on Fatigue Life of Rolling Contacts." In ASME/STLE 2007 International Joint Tribology Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/ijtc2007-44399.
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The values of residual stresses resulting from a heavily stressed contact are numerically evaluated by employing a three-dimensional strain deformation analysis model. The model is developed in the frame of the incremental theory of plasticity including the von Mises yield criterion, Prandtl-Reuss equations, and Ramberg-Osgood stress-strain equation. Two groups of cylindrical specimens were subjected to rolling contact fatigue, one as the reference group and the other with an induced residual stresses state. To obtain theoretical lives of the tested groups the von Mises equivalent stress is used in Ioannides-Harris rolling contact fatigue model. Both, the experimental data and theoretical analysis reveal more than two times greater fatigue life for the group with induced residual stresses versus the life of the reference group.
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Cretu, Spiridon. "Improvement of Rolling Contact Fatigue Life by a Preliminary Loading in Elastic-Plastic Domain." In ASME 2008 9th Biennial Conference on Engineering Systems Design and Analysis. ASMEDC, 2008. http://dx.doi.org/10.1115/esda2008-59137.
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An analysis model has been developed to model the nonlinear strain rate dependent deformation of rolling bearing steel stressed in the elastic-plastic domain. The model is developed in the frame of the incremental theory of plasticity by using the von Mises yield criterion and Prandtl-Reuss equations. By considering the isotropic and non-linear kinematic hardening laws of Lemaitre-Caboche, the model accounts for the cyclic hardening phenomena. To attain the final load of each loading cycle, the two bodies are brought into contact incrementally. For each new load increment new increments for the components of stress and strain tensors, but also increments of residual stresses, are computed for each point of the 3D mesh. Both, the new contact geometry and residual stresses distributions, are further considered as initial values for the next loading cycle, the incremental technique being reiterated. The cyclic evaluation process of both, plastic strains and residual stresses is performed until the material shakedowns. The experimental part of the paper regards to the rolling contact fatigue tests carried out on two groups of line contact test specimens and on two groups of deep groove ball bearings. In both cases, the experimental data reveal more than two times greater fatigue life for the group with induced residual stresses versus the life of the reference group. The von Mises equivalent stress is considered in Ioannides-Harris rolling contact fatigue model to obtain theoretical lives. The theoretical analysis revealed greater fatigue lives for the test specimens and for the ball bearings groups with induced residual stresses than the fatigue lives of the corresponding reference groups.
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Cretu, Spiridon S., Marcelin I. Benchea, and Ovidiu S. Cretu. "Compressive Residual Stresses Effect on Fatigue Life of Rolling Bearings." In ASME 2007 International Mechanical Engineering Congress and Exposition. ASMEDC, 2007. http://dx.doi.org/10.1115/imece2007-43561.
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The fatigue life tests carried out on two groups of ball bearings confirm the positive influence of the compressive residual stresses induced by a previous loading in the elastic-plastic domain. The values of residual stresses are numerically evaluated by employing a three-dimensional strain deformation analysis model. The model is developed in the frame of the incremental theory of plasticity by using the von Mises yield criterion and Prandtl-Reuss equations. To consider the material behaviour the Ramberg-Osgood stress-strain equation is involved and a nonlinear equation is considered to model the influence of the retained austenite. To attain the final load of each loading cycle the two bodies are brought into contact incrementally, so that for each new load increment the new pressure distribution is obtained as the solution of a constrained system of equation. Conjugate gradients method in conjunction with discrete convolution fast Fourier transform is used to solve the huge system of equations. Both the new contact geometry and residual stresses distributions, are further considered as initial values for the next loading cycle, the incremental technique being reiterated. The cyclic evaluation process of both plastic strains and residual stresses is performed until the material shakedowns. Comparisons of the computed residual stresses and deformed profiles with corresponding measured values reveal a good agreement and validate the analysis model. The von Mises equivalent stress, able to include both elastic and residual stresses, is considered in Ioannides-Harris rolling contact fatigue model to obtain theoretical lives of the ball bearings groups. The theoretical analysis reveals also greater fatigue lives for the ball bearings groups with induced residual stresses than the fatigue lives of the group without induced residual stresses.
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Khraisheh, Marwan, Naveen Thuramalla, Fadi Abu-Farha, and Pushkarraj Deshmukh. "Multi-Scale Analysis of Deformation and Failure of Superplastic Materials." In ASME 2003 International Mechanical Engineering Congress and Exposition. ASMEDC, 2003. http://dx.doi.org/10.1115/imece2003-43355.
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The superplastic deformation is modeled within the continuum theory of viscoplasticity with an anisotropic yield function and a microstructure-based overstress function. Grain growth and cavitation are incorporated in the model and their effects on the superplastic flow stress are investigated. In addition, a new multi-scale stability criterion for superplastic deformation taking into account both geometrical (macroscopic) and microstructural features including grain growth and cavitation is presented. The new stability criterion is based on Hart’s stability criterion and is obtained by combining a modified microstructure-based constitute model for superplastic deformation with grain and cavitation evolution equations. The effects of void fraction, grain size, and strain rate sensitivity on the stability of superplastic deformation are examined. Variable strain rate optimum forming paths are derived from the stability criterion and optimum pressure profiles for superplastic blow forming are generated using FE analysis.
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TINGER, HERBERT. "Analysis and application of aircraft departure prediction criteria to the AV-8B Harrier II." In 14th Atmospheric Flight Mechanics Conference. American Institute of Aeronautics and Astronautics, 1987. http://dx.doi.org/10.2514/6.1987-2561.
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Ganjo, D. G. A. "Criteria pollutant dispersion modeling analysis for the Harir Early Production Facility, Kurdistan Region of Iraq." In AIR POLLUTION 2012. WIT Press, 2012. http://dx.doi.org/10.2495/air120041.
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Ye, Yang. "Users’ Perceptions of Walkability Attributes in Residential Areas: Reliability and Validity." In 55th ISOCARP World Planning Congress, Beyond Metropolis, Jakarta-Bogor, Indonesia. ISOCARP, 2019. http://dx.doi.org/10.47472/drya8477.
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In recent years, urban environmental quality and urban vitality have attracted more scholars’ attention than ever as Chinese cities experienced a rapid development stage. To test the influence of urban built environment on walkability in residential areas, this study developed a questionnaire to perceive the users’ perception of walkability around their neighbourhood in residential areas, which was based on the Neighbourhood Environment Walkability Scale for Mainland China (NEWS-MC). The original Neighbourhood Environment Walkability Scale (NEWS) are developed for use in USA to measure residents’ perceptions of the environment attributes, and has been applied in many countries, such as US, Australia, Korea and Hong Kong, and be modify to be Neighbourhood Environment Walkability Scale for Mainland China (NEWS-MC) and been applied in Chinese cities. NEWS-MC has been found have moderate to high rest-retest reliabilities and good criterion The evidence illustrated high-walkable neighbourhoods be found with higher density, land-use mix, street connectivity, more safety and have more aesthetics elements. In this study, we modified NEWS-MC to reflect the characteristics of cold region Chinese built environment and people’s behaviour mode. To perceive the final version of Neighbourhood Environment Walkability Scale for cold region Chinese cities (NEWSCRC), We made a pilot study which include 50 samples, then interview 800 residents from 6 selected residential districts in Harbin (the capital city with highest latitude in China) which were different in walkability attributes and economic status. The final version of the NEWS-CRC included 8 subscales and 3 single items (76 items in total). Test-retest reliability showed moderate to high except 4 items . In total, the NEWS-CRC could illustrate residents’ perceptions of walkability attributes in cold region Chinese cities and could be use in other Chinese urban attributes studies related to walking
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Soliman, Nada Hossam, Ahmed T. M. Aboughalia, Tawanda Chivese, et al. "A Meta-Review of Meta-Analyses and an Updated Meta-Analysis on the Efficacy of Chloroquine and Hydroxychloroquine in treating COVID-19 Infection." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0308.
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Objective: To synthesize the findings presented in systematic reviews and meta-analyses as well as to update the evidence using a meta-analysis in evaluating the efficacy and safety of CQ and HCQ with or without Azithromycin for the treatment of COVID-19 infection. Methods: The design of this meta-review followed the preferred reporting items for overviews of systematic reviews including harms checklist (PRIO-harms). A comprehensive search included several electronic databases in identifying all systematic reviews and meta-analyses as well as experimental studies which investigated the efficacy and safety of CQ, HCQ with or without antibiotics as COVID-19 treatment. Findings from the systematic reviews and metaanalyses were reported using a structured summary including tables and forest plots. The updated metaanalyses of experimental studies was carried out using the distributional assumption-free quality effects model. Risk of bias was assessed using the assessing the methodological quality of systematic reviews (AMSTAR) tool for reviews and the methodological standard for epidemiological research (MASTER) scale for the experimental studies. The main outcome for both the meta-review and the updated metaanalyses was mortality. Secondary outcomes included transfer to the intensive care unit (ICU) or mechanical ventilation, worsening of illness, viral clearance and the occurrence of adverse events. Results: A total of 13 reviews with 40 primary studies comprising 113,000 participants were included. Most of the primary studies were observational (n=27) and the rest were experimental studies. Two meta-analyses reported a high risk of mortality with similar ORs of 2.5 for HCQ with Azithromycin. However, four other metaanalyses reported contradictory results with two reporting a high risk of mortality and the other two reporting no significant association between HCQ with mortality. Most reviews reported that HCQ with or without Azithromycin had no significant effect on virological cure, disease exacerbation or the risk of transfer to the ICU, need for intubation or mechanical ventilation. After exclusion of studies that did not meet the eligibility criteria, the updated meta-analysis contained eight experimental studies (7 RCTs and 1 quasiexperimental trial), with a total of 5279 participants of whom 1856 were on either CQ/HCQ or combined with Azithromycin. CQ/HCQ with or without Azithromycin was significantly associated with a higher risk of adverse events. HCQ was not effective in reducing mortality transfer to the ICU, intubation or need for mechanical ventilation virological cure (RR 1.0, 95%CI 0.9-1.2, I2 =55%, n=5 studies) nor disease exacerbation (RR 1.2, 95%CI 0.3-5.0, I2 =29%, n=3 studies). Conclusion: There is conclusive evidence that CQ and HCQ, with or without Azithromycin are not effective in treating COVID-19 or its exacerbation.
Reports on the topic "Harris criterion"
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Chou, Roger, Rongwei Fu, Tracy Dana, Miranda Pappas, Erica Hart, and Kimberly M. Mauer. Interventional Treatments for Acute and Chronic Pain: Systematic Review. Agency for Healthcare Research and Quality (AHRQ), 2021. http://dx.doi.org/10.23970/ahrqepccer247.
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Objective. To evaluate the benefits and harms of selected interventional procedures for acute and chronic pain that are not currently covered by the Centers for Medicare & Medicaid Services (CMS) but are relevant for and have potential utility for use in the Medicare population, or that are covered by CMS but for which there is important uncertainty or controversy regarding use. Data sources. Electronic databases (Ovid® MEDLINE®, PsycINFO®, the Cochrane Central Register of Controlled Trials, and the Cochrane Database of Systematic Reviews) to April 12, 2021, reference lists, and submissions in response to a Federal Register notice. Review methods. Using predefined criteria and dual review, we selected randomized controlled trials (RCTs) for 10 interventional procedures and conditions that evaluated pain, function, health status, quality of life, medication use, and harms. Random effects meta-analysis was conducted for vertebral compression fracture; otherwise, outcomes were synthesized qualitatively. Effects were classified as small, moderate, or large using previously defined criteria. Results. Thirty-seven randomized trials (in 48 publications) were included. Vertebroplasty (13 trials) is probably more effective at reducing pain and improving function in older (>65 years of age) patients, but benefits are small (less than 1 point on a 10-point pain scale). Benefits appear smaller (but still present) in sham-controlled (5 trials) compared with usual care controlled trials (8 trials) and larger in trials of patients with more acute symptoms; however, testing for subgroup effects was limited by imprecision. Vertebroplasty is probably not associated with increased risk of incident vertebral fracture (10 trials). Kyphoplasty (2 trials) is probably more effective than usual care for pain and function in older patients with vertebral compression fracture at up to 1 month (moderate to large benefits) and may be more effective at >1 month to ≥1 year (small to moderate benefits) but has not been compared against sham therapy. Evidence on kyphoplasty and risk of incident fracture was conflicting. In younger (below age for Medicare eligibility) populations, cooled radiofrequency denervation for sacroiliac pain (2 trials) is probably more effective for pain and function versus sham at 1 and 3 months (moderate to large benefits). Cooled radiofrequency for presumed facet joint pain may be similarly effective versus conventional radiofrequency, and piriformis injection with corticosteroid for piriformis syndrome may be more effective than sham injection for pain. For the other interventional procedures and conditions addressed, evidence was too limited to determine benefits and harms. Conclusions. Vertebroplasty is probably effective at reducing pain and improving function in older patients with vertebral compression fractures; benefits are small but similar to other therapies recommended for pain. Evidence was too limited to separate effects of control type and symptom acuity on effectiveness of vertebroplasty. Kyphoplasty has not been compared against sham but is probably more effective than usual care for vertebral compression fractures in older patients. In younger populations, cooled radiofrequency denervation is probably more effective than sham for sacroiliac pain. Research is needed to determine the benefits and harms of the other interventional procedures and conditions addressed in this review.
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Chou, Roger, Jesse Wagner, Azrah Y. Ahmed, et al. Treatments for Acute Pain: A Systematic Review. Agency for Healthcare Research and Quality (AHRQ), 2020. http://dx.doi.org/10.23970/ahrqepccer240.
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Objectives. To evaluate the effectiveness and comparative effectiveness of opioid, nonopioid pharmacologic, and nonpharmacologic therapy in patients with specific types of acute pain, including effects on pain, function, quality of life, adverse events, and long-term use of opioids. Data sources. Electronic databases (Ovid® MEDLINE®, PsycINFO®, Embase®, the Cochrane Central Register of Controlled Trials, and the Cochrane Database of Systematic Reviews) to August 2020, reference lists, and a Federal Register notice. Review methods. Using predefined criteria and dual review, we selected randomized controlled trials (RCTs) of outpatient therapies for eight acute pain conditions: low back pain, neck pain, other musculoskeletal pain, neuropathic pain, postoperative pain following discharge, dental pain (surgical or nonsurgical), pain due to kidney stones, and pain due to sickle cell disease. Meta-analyses were conducted on pharmacologic therapy for dental pain and kidney stone pain, and likelihood of repeat or rescue medication use and adverse events. The magnitude of effects was classified as small, moderate, or large using previously defined criteria, and strength of evidence was assessed. Results. One hundred eighty-three RCTs on the comparative effectiveness of therapies for acute pain were included. Opioid therapy was probably less effective than nonsteroidal anti-inflammatory drugs (NSAIDs) for surgical dental pain and kidney stones, and might be similarly effective as NSAIDs for low back pain. Opioids and NSAIDs were more effective than acetaminophen for surgical dental pain, but opioids were less effective than acetaminophen for kidney stone pain. For postoperative pain, opioids were associated with increased likelihood of repeat or rescue analgesic use, but effects on pain intensity were inconsistent. Being prescribed an opioid for acute low back pain or postoperative pain was associated with increased likelihood of use of opioids at long-term followup versus not being prescribed, based on observational studies. Heat therapy was probably effective for acute low back pain, spinal manipulation might be effective for acute back pain with radiculopathy, acupressure might be effective for acute musculoskeletal pain, an opioid might be effective for acute neuropathic pain, massage might be effective for some types of postoperative pain, and a cervical collar or exercise might be effective for acute neck pain with radiculopathy. Most studies had methodological limitations. Effect sizes were primarily small to moderate for pain, the most commonly evaluated outcome. Opioids were associated with increased risk of short-term adverse events versus NSAIDs or acetaminophen, including any adverse event, nausea, dizziness, and somnolence. Serious adverse events were uncommon for all interventions, but studies were not designed to assess risk of overdose, opioid use disorder, or long-term harms. Evidence on how benefits or harms varied in subgroups was lacking. Conclusions. Opioid therapy was associated with decreased or similar effectiveness as an NSAID for some acute pain conditions, but with increased risk of short-term adverse events. Evidence on nonpharmacological therapies was limited, but heat therapy, spinal manipulation, massage, acupuncture, acupressure, a cervical collar, and exercise were effective for specific acute pain conditions. Research is needed to determine the comparative effectiveness of therapies for sickle cell pain, acute neuropathic pain, neck pain, and management of postoperative pain following discharge; effects of therapies for acute pain on non-pain outcomes; effects of therapies on long-term outcomes, including long-term opioid use; and how benefits and harms of therapies vary in subgroups.
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Viswanathan, Meera, Jennifer Cook Middleton, Alison Stuebe, et al. Maternal, Fetal, and Child Outcomes of Mental Health Treatments in Women: A Systematic Review of Perinatal Pharmacologic Interventions. Agency for Healthcare Research and Quality (AHRQ), 2021. http://dx.doi.org/10.23970/ahrqepccer236.
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Background. Untreated maternal mental health disorders can have devastating sequelae for the mother and child. For women who are currently or planning to become pregnant or are breastfeeding, a critical question is whether the benefits of treating psychiatric illness with pharmacologic interventions outweigh the harms for mother and child. Methods. We conducted a systematic review to assess the benefits and harms of pharmacologic interventions compared with placebo, no treatment, or other pharmacologic interventions for pregnant and postpartum women with mental health disorders. We searched four databases and other sources for evidence available from inception through June 5, 2020 and surveilled the literature through March 2, 2021; dually screened the results; and analyzed eligible studies. We included studies of pregnant, postpartum, or reproductive-age women with a new or preexisting diagnosis of a mental health disorder treated with pharmacotherapy; we excluded psychotherapy. Eligible comparators included women with the disorder but no pharmacotherapy or women who discontinued the pharmacotherapy before pregnancy. Results. A total of 164 studies (168 articles) met eligibility criteria. Brexanolone for depression onset in the third trimester or in the postpartum period probably improves depressive symptoms at 30 days (least square mean difference in the Hamilton Rating Scale for Depression, -2.6; p=0.02; N=209) when compared with placebo. Sertraline for postpartum depression may improve response (calculated relative risk [RR], 2.24; 95% confidence interval [CI], 0.95 to 5.24; N=36), remission (calculated RR, 2.51; 95% CI, 0.94 to 6.70; N=36), and depressive symptoms (p-values ranging from 0.01 to 0.05) when compared with placebo. Discontinuing use of mood stabilizers during pregnancy may increase recurrence (adjusted hazard ratio [AHR], 2.2; 95% CI, 1.2 to 4.2; N=89) and reduce time to recurrence of mood disorders (2 vs. 28 weeks, AHR, 12.1; 95% CI, 1.6 to 91; N=26) for bipolar disorder when compared with continued use. Brexanolone for depression onset in the third trimester or in the postpartum period may increase the risk of sedation or somnolence, leading to dose interruption or reduction when compared with placebo (5% vs. 0%). More than 95 percent of studies reporting on harms were observational in design and unable to fully account for confounding. These studies suggested some associations between benzodiazepine exposure before conception and ectopic pregnancy; between specific antidepressants during pregnancy and adverse maternal outcomes such as postpartum hemorrhage, preeclampsia, and spontaneous abortion, and child outcomes such as respiratory issues, low Apgar scores, persistent pulmonary hypertension of the newborn, depression in children, and autism spectrum disorder; between quetiapine or olanzapine and gestational diabetes; and between benzodiazepine and neonatal intensive care admissions. Causality cannot be inferred from these studies. We found insufficient evidence on benefits and harms from comparative effectiveness studies, with one exception: one study suggested a higher risk of overall congenital anomalies (adjusted RR [ARR], 1.85; 95% CI, 1.23 to 2.78; N=2,608) and cardiac anomalies (ARR, 2.25; 95% CI, 1.17 to 4.34; N=2,608) for lithium compared with lamotrigine during first- trimester exposure. Conclusions. Few studies have been conducted in pregnant and postpartum women on the benefits of pharmacotherapy; many studies report on harms but are of low quality. The limited evidence available is consistent with some benefit, and some studies suggested increased adverse events. However, because these studies could not rule out underlying disease severity as the cause of the association, the causal link between the exposure and adverse events is unclear. Patients and clinicians need to make an informed, collaborative decision on treatment choices.
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Carney, Nancy, Tamara Cheney, Annette M. Totten, et al. Prehospital Airway Management: A Systematic Review. Agency for Healthcare Research and Quality (AHRQ), 2021. http://dx.doi.org/10.23970/ahrqepccer243.
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Objective. To assess the comparative benefits and harms across three airway management approaches (bag valve mask [BVM], supraglottic airway [SGA], and endotracheal intubation [ETI]) by emergency medical services in the prehospital setting, and how the benefits and harms differ based on patient characteristics, techniques, and devices. Data sources. We searched electronic citation databases (Ovid® MEDLINE®, CINAHL®, the Cochrane Central Register of Controlled Trials, the Cochrane Database of Systematic Reviews, and Scopus®) from 1990 to September 2020 and reference lists, and posted a Federal Register notice request for data. Review methods. Review methods followed Agency for Healthcare Research and Quality Evidence-based Practice Center Program methods guidance. Using pre-established criteria, studies were selected and dual reviewed, data were abstracted, and studies were evaluated for risk of bias. Meta-analyses using profile-likelihood random effects models were conducted when data were available from studies reporting on similar outcomes, with analyses stratified by study design, emergency type, and age. We qualitatively synthesized results when meta-analysis was not indicated. Strength of evidence (SOE) was assessed for primary outcomes (survival, neurological function, return of spontaneous circulation [ROSC], and successful advanced airway insertion [for SGA and ETI only]). Results. We included 99 studies (22 randomized controlled trials and 77 observational studies) involving 630,397 patients. Overall, we found few differences in primary outcomes when airway management approaches were compared. • For survival, there was moderate SOE for findings of no difference for BVM versus ETI in adult and mixed-age cardiac arrest patients. There was low SOE for no difference in these patients for BVM versus SGA and SGA versus ETI. There was low SOE for all three comparisons in pediatric cardiac arrest patients, and low SOE in adult trauma patients when BVM was compared with ETI. • For neurological function, there was moderate SOE for no difference for BVM compared with ETI in adults with cardiac arrest. There was low SOE for no difference in pediatric cardiac arrest for BVM versus ETI and SGA versus ETI. In adults with cardiac arrest, neurological function was better for BVM and ETI compared with SGA (both low SOE). • ROSC was applicable only in cardiac arrest. For adults, there was low SOE that ROSC was more frequent with SGA compared with ETI, and no difference for BVM versus SGA or BVM versus ETI. In pediatric patients there was low SOE of no difference for BVM versus ETI and SGA versus ETI. • For successful advanced airway insertion, low SOE supported better first-pass success with SGA in adult and pediatric cardiac arrest patients and adult patients in studies that mixed emergency types. Low SOE also supported no difference for first-pass success in adult medical patients. For overall success, there was moderate SOE of no difference for adults with cardiac arrest, medical, and mixed emergency types. • While harms were not always measured or reported, moderate SOE supported all available findings. There were no differences in harms for BVM versus SGA or ETI. When SGA was compared with ETI, there were no differences for aspiration, oral/airway trauma, and regurgitation; SGA was better for multiple insertion attempts; and ETI was better for inadequate ventilation. Conclusions. The most common findings, across emergency types and age groups, were of no differences in primary outcomes when prehospital airway management approaches were compared. As most of the included studies were observational, these findings may reflect study design and methodological limitations. Due to the dynamic nature of the prehospital environment, the results are susceptible to indication and survival biases as well as confounding; however, the current evidence does not favor more invasive airway approaches. No conclusion was supported by high SOE for any comparison and patient group. This supports the need for high-quality randomized controlled trials designed to account for the variability and dynamic nature of prehospital airway management to advance and inform clinical practice as well as emergency medical services education and policy, and to improve patient-centered outcomes.
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Treadwell, Jonathan R., James T. Reston, Benjamin Rouse, Joann Fontanarosa, Neha Patel, and Nikhil K. Mull. Automated-Entry Patient-Generated Health Data for Chronic Conditions: The Evidence on Health Outcomes. Agency for Healthcare Research and Quality (AHRQ), 2021. http://dx.doi.org/10.23970/ahrqepctb38.
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Background. Automated-entry consumer devices that collect and transmit patient-generated health data (PGHD) are being evaluated as potential tools to aid in the management of chronic diseases. The need exists to evaluate the evidence regarding consumer PGHD technologies, particularly for devices that have not gone through Food and Drug Administration evaluation. Purpose. To summarize the research related to automated-entry consumer health technologies that provide PGHD for the prevention or management of 11 chronic diseases. Methods. The project scope was determined through discussions with Key Informants. We searched MEDLINE and EMBASE (via EMBASE.com), In-Process MEDLINE and PubMed unique content (via PubMed.gov), and the Cochrane Database of Systematic Reviews for systematic reviews or controlled trials. We also searched ClinicalTrials.gov for ongoing studies. We assessed risk of bias and extracted data on health outcomes, surrogate outcomes, usability, sustainability, cost-effectiveness outcomes (quantifying the tradeoffs between health effects and cost), process outcomes, and other characteristics related to PGHD technologies. For isolated effects on health outcomes, we classified the results in one of four categories: (1) likely no effect, (2) unclear, (3) possible positive effect, or (4) likely positive effect. When we categorized the data as “unclear” based solely on health outcomes, we then examined and classified surrogate outcomes for that particular clinical condition. Findings. We identified 114 unique studies that met inclusion criteria. The largest number of studies addressed patients with hypertension (51 studies) and obesity (43 studies). Eighty-four trials used a single PGHD device, 23 used 2 PGHD devices, and the other 7 used 3 or more PGHD devices. Pedometers, blood pressure (BP) monitors, and scales were commonly used in the same studies. Overall, we found a “possible positive effect” of PGHD interventions on health outcomes for coronary artery disease, heart failure, and asthma. For obesity, we rated the health outcomes as unclear, and the surrogate outcomes (body mass index/weight) as likely no effect. For hypertension, we rated the health outcomes as unclear, and the surrogate outcomes (systolic BP/diastolic BP) as possible positive effect. For cardiac arrhythmias or conduction abnormalities we rated the health outcomes as unclear and the surrogate outcome (time to arrhythmia detection) as likely positive effect. The findings were “unclear” regarding PGHD interventions for diabetes prevention, sleep apnea, stroke, Parkinson’s disease, and chronic obstructive pulmonary disease. Most studies did not report harms related to PGHD interventions; the relatively few harms reported were minor and transient, with event rates usually comparable to harms in the control groups. Few studies reported cost-effectiveness analyses, and only for PGHD interventions for hypertension, coronary artery disease, and chronic obstructive pulmonary disease; the findings were variable across different chronic conditions and devices. Patient adherence to PGHD interventions was highly variable across studies, but patient acceptance/satisfaction and usability was generally fair to good. However, device engineers independently evaluated consumer wearable and handheld BP monitors and considered the user experience to be poor, while their assessment of smartphone-based electrocardiogram monitors found the user experience to be good. Student volunteers involved in device usability testing of the Weight Watchers Online app found it well-designed and relatively easy to use. Implications. Multiple randomized controlled trials (RCTs) have evaluated some PGHD technologies (e.g., pedometers, scales, BP monitors), particularly for obesity and hypertension, but health outcomes were generally underreported. We found evidence suggesting a possible positive effect of PGHD interventions on health outcomes for four chronic conditions. Lack of reporting of health outcomes and insufficient statistical power to assess these outcomes were the main reasons for “unclear” ratings. The majority of studies on PGHD technologies still focus on non-health-related outcomes. Future RCTs should focus on measurement of health outcomes. Furthermore, future RCTs should be designed to isolate the effect of the PGHD intervention from other components in a multicomponent intervention.
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McDonagh, Marian S., Jesse Wagner, Azrah Y. Ahmed, Benjamin Morasco, Devan Kansagara, and Roger Chou. Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain: May 2021 Update. Agency for Healthcare Research and Quality (AHRQ), 2021. http://dx.doi.org/10.23970/ahrqepccerplantpain3.
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Overview This is the third quarterly progress report for an ongoing living systematic review on cannabis and other plant-based treatments for chronic pain. The first progress report was published in January 2021 and the second in March 2021. The draft systematic review was available for public comment from May 19 through June 15, 2021, on the Agency for Healthcare Research and Quality (AHRQ) Effective Health Care website. The systematic review synthesizes evidence on the benefits and harms of plant-based compounds (PBCs), such as cannabinoids and kratom, used to treat chronic pain, addressing concerns about severe adverse effects, abuse, misuse, dependence, and addiction. The purpose of this progress report is to describe the cumulative literature identified thus far. This report will be periodically updated with new studies as they are published and identified, culminating in an annual systematic review that provides a synthesis of the accumulated evidence. Main Points In patients with chronic (mainly neuropathic) pain with short-term treatment (4 weeks to <6 months): • Studies of cannabis-related products were grouped based on their tetrahydrocannabinol (THC) to cannabidiol (CBD) ratio using the following categories: high THC to CBD, comparable THC to CBD, and low THC to CBD. • Comparable THC to CBD ratio oral spray is probably associated with small improvements in pain severity and may be associated with small improvements in function. There was no effect in pain interference or serious adverse events. There may be a large increased risk of dizziness and sedation, and a moderate increased risk of nausea. • Synthetic THC (high THC to CBD) may be associated with moderate improvement in pain severity and increased risk of sedation, and large increased risk of nausea. Synthetic THC is probably associated with a large increased risk of dizziness. • Extracted whole-plant high THC to CBD ratio products may be associated with large increases in risk of withdrawal due to adverse events and dizziness. • Evidence on whole-plant cannabis, low THC to CBD ratio products (topical CBD), other cannabinoids (cannabidivarin), and comparisons with other active interventions was insufficient to draw conclusions. • Other key adverse event outcomes (psychosis, cannabis use disorder, cognitive deficits) and outcomes on the impact on opioid use were not reported. • No evidence on other plant-based compounds, such as kratom, met criteria for this review.
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McDonagh, Marian, Andrea C. Skelly, Amy Hermesch, et al. Cervical Ripening in the Outpatient Setting. Agency for Healthcare Research and Quality (AHRQ), 2021. http://dx.doi.org/10.23970/ahrqepccer238.
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Objectives. To assess the comparative effectiveness and potential harms of cervical ripening in the outpatient setting (vs. inpatient, vs. other outpatient intervention) and of fetal surveillance when a prostaglandin is used for cervical ripening. Data sources. Electronic databases (Ovid® MEDLINE®, Embase®, CINAHL®, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews) to July 2020; reference lists; and a Federal Register notice. Review methods. Using predefined criteria and dual review, we selected randomized controlled trials (RCTs) and cohort studies of cervical ripening comparing prostaglandins and mechanical methods in outpatient versus inpatient settings; one outpatient method versus another (including placebo or expectant management); and different methods/protocols for fetal surveillance in cervical ripening using prostaglandins. When data from similar study designs, populations, and outcomes were available, random effects using profile likelihood meta-analyses were conducted. Inconsistency (using I2) and small sample size bias (publication bias, if ≥10 studies) were assessed. Strength of evidence (SOE) was assessed. All review methods followed Agency for Healthcare Research and Quality Evidence-based Practice Center methods guidance. Results. We included 30 RCTs and 10 cohort studies (73% fair quality) involving 9,618 women. The evidence is most applicable to women aged 25 to 30 years with singleton, vertex presentation and low-risk pregnancies. No studies on fetal surveillance were found. The frequency of cesarean delivery (2 RCTs, 4 cohort studies) or suspected neonatal sepsis (2 RCTs) was not significantly different using outpatient versus inpatient dinoprostone for cervical ripening (SOE: low). In comparisons of outpatient versus inpatient single-balloon catheters (3 RCTs, 2 cohort studies), differences between groups on cesarean delivery, birth trauma (e.g., cephalohematoma), and uterine infection were small and not statistically significant (SOE: low), and while shoulder dystocia occurred less frequently in the outpatient group (1 RCT; 3% vs. 11%), the difference was not statistically significant (SOE: low). In comparing outpatient catheters and inpatient dinoprostone (1 double-balloon and 1 single-balloon RCT), the difference between groups for both cesarean delivery and postpartum hemorrhage was small and not statistically significant (SOE: low). Evidence on other outcomes in these comparisons and for misoprostol, double-balloon catheters, and hygroscopic dilators was insufficient to draw conclusions. In head to head comparisons in the outpatient setting, the frequency of cesarean delivery was not significantly different between 2.5 mg and 5 mg dinoprostone gel, or latex and silicone single-balloon catheters (1 RCT each, SOE: low). Differences between prostaglandins and placebo for cervical ripening were small and not significantly different for cesarean delivery (12 RCTs), shoulder dystocia (3 RCTs), or uterine infection (7 RCTs) (SOE: low). These findings did not change according to the specific prostaglandin, route of administration, study quality, or gestational age. Small, nonsignificant differences in the frequency of cesarean delivery (6 RCTs) and uterine infection (3 RCTs) were also found between dinoprostone and either membrane sweeping or expectant management (SOE: low). These findings did not change according to the specific prostaglandin or study quality. Evidence on other comparisons (e.g., single-balloon catheter vs. dinoprostone) or other outcomes was insufficient. For all comparisons, there was insufficient evidence on other important outcomes such as perinatal mortality and time from admission to vaginal birth. Limitations of the evidence include the quantity, quality, and sample sizes of trials for specific interventions, particularly rare harm outcomes. Conclusions. In women with low-risk pregnancies, the risk of cesarean delivery and fetal, neonatal, or maternal harms using either dinoprostone or single-balloon catheters was not significantly different for cervical ripening in the outpatient versus inpatient setting, and similar when compared with placebo, expectant management, or membrane sweeping in the outpatient setting. This evidence is low strength, and future studies are needed to confirm these findings.