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Journal articles on the topic 'Hashimoto thyroiditis'
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Karki, Prakriti, Parikshit Prasai, Vivek Acharya Chetri, Arun Gautam, and Robin Maskey. "Autoimmune Hemolytic Anemia with Autoimmune Hypothyroidism: A Case Report." Journal of Nepal Medical Association 61, no. 263 (2023): 614–16. http://dx.doi.org/10.31729/jnma.8217.
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Autoimmune hemolytic anaemia is a relatively rare disorder caused by autoantibodies directed against self-red blood cells. Though autoimmune thyroid disease is associated with other autoimmune diseases, only a few cases of Hashimoto's thyroiditis with autoimmune hemolytic anaemia have been reported. We present a case of a 22-year-old woman, a known case of Hashimoto’s thyroiditis whose serum demonstrated antibodies against red blood cells. Blood investigations were done which showed findings suggestive of hemolytic anemia. She was managed with blood transfusion, thyroxine and steroids.Our study may guide physicians toward possible hemolytic anaemia while treating Hashimoto thyroiditis.
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Ahmed, Rania, Safa Al-Shaikh, and Mohammed Akhtar. "Hashimoto Thyroiditis." Advances In Anatomic Pathology 19, no. 3 (2012): 181–86. http://dx.doi.org/10.1097/pap.0b013e3182534868.
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Lichtenstein, A. O., and A. A. Agafonov. "Hashimoto type thyroiditis." Kazan medical journal 43, no. 5 (2021): 55–56. http://dx.doi.org/10.17816/kazmj87888.
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Thyroiditis (struma limfomatosa - Hashimoto's disease) is a two-sided diffuse dense goiter, intimately fused with the trachea. Fusion with other organs and tissues is not observed. At the same time, the thyroid gland is often slightly enlarged and can cause compression of the trachea, which leads to hoarseness. The disease usually affects older women over 40 years of age (Babcock). On the cut, the tissue of the thyroid gland is dense, whitish, with significant lymphoid infiltration, proliferation of connective tissue, atrophy of the glandular tissue and degeneration of the epithelium. Struma Hashimoto was considered a disease of the Anglo-Saxon countries, where about 200 observations are described. However, in recent years, the domestic literature has been significantly enriched with reports of chronic lymphoid thyroiditis.
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Kasprzak, Amelia, Aleksandra Mańkowska, Monika Truchta, et al. "Vitamin D supplementation in patients with Hashimoto’s disease." Journal of Education, Health and Sport 53 (January 18, 2024): 125–36. http://dx.doi.org/10.12775/jehs.2024.53.009.
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Introduction : Hashimoto’s thyroiditis (HT) is the most common autoimmune disease and the leading cause of hypothyroidism in the world. The condition results in damage to the thyroid gland, brought about by the infiltration of lymphocytes. For the majority of individuals with Hashimoto's thyroiditis, a lifelong requirement for levothyroxine substitution is required. The potential contribution of diet and supplements to the management of HT is frequently overlooked. Low vitamin D levels are said to play a significant role in occurrence and severity of autoimmune thyroiditis. Currently, there is a continuing discussion regarding the optimal plasma concentration of 25-hydroxyvitamin D necessary for preventing or treating autoimmune diseases.
 
 Aim of the study : The purpose of this literature review is to evaluate the influence of vitamin D supplementation on the course of Hashimoto’s thyroiditis in the light of most up to date research.
 
 Materials and methods. This article is a review of publications obtained from the PubMed database, published between 2017-2023, based on the keywords "Hashimoto thyroiditis" "vitamin D" and "autoimmune thyroid disease".
 
 Conclusions. The correlation of vitamin D supplementation and Hashimoto’s disease still remains unclear due to conflicting results from numerous studies. Further research is necessary to accurately determine the effect of vitamin D supplementation on Hashimoto’s thyroiditis.
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Thomsen, Hauke, Xinjun Li, Kristina Sundquist, Jan Sundquist, Asta Försti, and Kari Hemminki. "Familial risks between Graves disease and Hashimoto thyroiditis and other autoimmune diseases in the population of Sweden." Journal of translational autoimmunity 3, no. 1 (2020): 1–5. https://doi.org/10.1016/j.jtauto.2020.100058.
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Genetic and family studies have indicated that Graves disease and Hashimoto thyroiditis have a heritable component which appears to be shared to some extend also with some other autoimmune diseases (AIDs). In the present nation-wide study we describe familial risk for Graves disease and Hashimoto thyroiditis identified from the Swedish Hospital Discharge Register (years 1964 through 2012) and the Outpatient Register (2001 through 2012). Family relationships were obtained from the Multigeneration Register and cancers from the Cancer Registry. Familial standardized incidence ratios (SIRs) were calculated for 29,005 offspring with Graves disease and for 25,607 offspring with Hashimoto thyroiditis depending on any of 43 AIDs in parents or siblings. The concordant familial risks for Graves disease and Hashimoto thyroiditis were 3.85 and 4.75, higher for men than for women. The familial risks were very high (11.35, Graves and 22.06, Hashimoto) when both a parent and a sibling were affected. Spousal familial risks were higher for Hashimoto thyroiditis (1.98/1.93) than for Graves disease (1.48/1.50). For Graves disease, 24 discordant AIDs showed a significant association; for Hashimoto thyroiditis, 20 discordant associations were significant. All significant discordant associations were positive for the two thyroid AIDs, with the exception of Hashimoto thyroiditis with Reiter disease. Overall 8 associations were significant only for Graves disease and 6 Hashimoto thyroiditis. The overall high concordant familial risks for Graves disease and Hashimoto thyroiditis suggest a strong genetic contribution to the familial risk. Significant familial associations among more than half of the 43 AIDs attest to the extensive polyautoimmunity among thyroid AIDs.
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Pakdaman, Michael Navid, Michael P. Hier, Martin J. Black, Michael Tamilia, and Richard J. Payne. "Micropapillary Thyroid Carcinoma and Hashimoto's Thyroiditis." Otolaryngology–Head and Neck Surgery 139, no. 2_suppl (2008): P40. http://dx.doi.org/10.1016/j.otohns.2008.05.132.
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Objective An increase in papillary thyroid carcinoma in patients with Hashimoto's thyroiditis has been described. We have yet to find literature discussing a relationship with micropapillary thyroid carcinoma(MPC). Our objective is (1) to assess the relationship between Papillary Microcarcinoma and Hashimoto's Thyroiditis in thyroids without malignant disease, (2) compare effect of the presence of Hashimoto's on prognostic factors in patients. Methods Pathology reports were reviewed for consecutive patients undergoing total thyroidectomy over a 6-year period from 2002 to 2007. Patients with benign pathologies were included. Patients with MPC and no other malignancy were also included. This lead to a cohort of 314 patients. Statistical significance was calculated using Fisher's exact test and a chi-squared analysis. Results Out of the 314 patients, 98 were positive for Hashimoto's thyroiditis on biopsy of the removed thyroid. 58% of the patients with Hashimoto's thyroiditis had an incidental MPC, as compared to 42% of patients where Hashimoto's was not found. Additionally, in Hashimoto patients, 61% of the MPCs were multifocal versus 43% multifocal in the non-Hashimoto group (p-value <0.05 in each comparison). Bilaterality of MPC was also increased in patients with Hashimoto's (22% vs 39%). Conclusions Patients with Hashimoto's thyroiditis in this study had an incidence of MPC of 58%, which is significantly greater than the 42% in those without. Hashimoto's was also associated with an increased risk of bilaterality and multifocality. Studies are needed to further corroborate these findings.
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Thompson, Lester D. R. "Chronic Lymphocytic Thyroiditis (Hashimoto Thyroiditis)." Ear, Nose & Throat Journal 93, no. 4-5 (2014): 152–53. http://dx.doi.org/10.1177/0145561314093004-508.
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Hapsari, Siti Nurul, and Sidarti Soehita. "HASHIMOTO’S THYROIDITIS HYPERTHYROID STAGE." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 26, no. 1 (2019): 123. http://dx.doi.org/10.24293/ijcpml.v26i1.1423.
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Preliminary: Hashimoto thyroiditis (chronic autoimmune thyroiditis) is the most common cause of hypothyroidism in iodine- sufficient areas of the world, but can sometimes show hyperthyroidism. Case: A 39-year-old female was referred due to shortness of breath and tremor, four hours before hospitalization. There was nausea, chest pain, cold chills and palpitation. She was diagnosed with Hashimoto’s thyroiditis and routinely received tyrosol, propanolol and dexamethasone. Physical examination: cervical mass, afebrile, blood pressure 130/70 mmHg, pulse rate 110 x/minute and respiratory rate 20 x /minute. Laboratory examinations showed WBC 7.53 x 109/L, Hb 11.0 g/dL and platelet count 168 x 109/L. Chest X-Ray: negative for infiltrates. Several laboratory tests were performed, abnormal results were as follows: FT4 2.96 ng/dL (increased), TSH 0.003 uIU/mL (decreased), anti-TPO (antithyroid microsomal antibody) 306 IU/ml (increased), Ig E 213.6 IU/mL (increased). Peripheral blood smear, coagulation test, serum electrolytes, liver function tests, renal function tests, urinalysis, CEA and Ca 125 were within normal limits. A thyroid ultrasound resulted in a benign lesion. Fine Needle Aspiration Biopsy concluded in lymphocytic Hashimoto’s thyroiditis. Echocardiography showed hyperthyroid heart disease. Discussion: Due to an increase in anti-TPO and FT4, a decrease in TSH and lymphocytic thyroiditis from FNAB, this patient was diagnosed with Hashimoto’s Thyroiditis Hyperthyroid Stage. Conclusion: Thyroid function tests and thyroid antibody tests must be monitored to decide whether it is hyperthyroid or hypothyroid stage of Hashimoto thyroiditis.
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Sobolevskaia, Polina A., Boris V. Andreev, Anton N. Gvozdetckii, et al. "The association of neuropsychiatric disorders and endocrine parameters in hashimoto thyroiditis." Pediatrician (St. Petersburg) 11, no. 4 (2020): 55–68. http://dx.doi.org/10.17816/ped11455-68.
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Hashimoto thyroiditis is the most common thyroid disease. This form of pathology has a diverse clinical picture, including neuropsychiatric disorders. There are frequent cases of comorbidity of autoimmune thyroiditis and psychiatric forms of pathology, along with such a nosological entity as Hashimotos encephalopathy (aka: Steroid-responsive encephalopathy of autoimmune thyroiditis), characterized by an increased level of antithyroid autoantibodies and various mental disorders, with still unclear pathogenesis. The question arises, how to regard patients with psychiatric disorders and Hashimoto thyroiditis either as patients having autoimmune thyroiditis, comorbid with psychiatric forms of pathology, or as patients with Hashimotos encephalopathy? We studied groups of patients with autoimmune thyroiditis free from any psychiatric disorders, autoimmune thyroiditis comorbid with psychiatric forms of pathology, and a group of healthy donors similar as regards to their age and sex. We also studied medical history, clinical manifestations of the disease, instrumental data and the serum levels of thyrotropin, thyroid hormones, various antithyroid autoantibodies, and prolactin. We analyzed the correlation of laboratory and instrumental parameters and clinical data in all groups of patients. Therewas a significant relationship (p 0,05) between various psychiatric symptoms and a decreased level of free thyroxine, an increased level of thyroid stimulating hormone (TSH), an increased level of prolactin and an increased volume of a thyroid gland. Asignificant relationship (p 0,05) was also found between various symptoms of hypothyroidism and a decreased level of free triiodothyronine (FT3), an increased level of antibodies to thyroglobulin (anti-TG Ab), and an increased level of antibodies to thyroid peroxidase (anti-TPO Ab).
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Moghimi, Mansour, Fateme Sadat Shamsadini Ezabadi, Seyed Mohammadreza Mortazavi Zadeh, and Saead Hossein Khalilzade. "Clinico-pathological Features and Survival Time of Papillary Thyroid Carcinoma in Patients With and Without Hashimoto’s Thyroiditis: A Cross-sectional Study." Crescent Journal of Medical and Biological Sciences 10, no. 4 (2022): 188–92. http://dx.doi.org/10.34172/cjmb.2023.45.
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Objectives: Researchers have reported different results regarding the association between Hashimoto’s disease and papillary thyroid carcinoma (PTC). Some believe that the coexistence of these diseases can lead to fewer tumor invasion and recurrence rates. This study evaluated the clinico-pathological features and survival time of PTC in patients with and without Hashimoto’s thyroiditis. Materials and Methods: In this cross-sectional study, medical records of 251 participants who underwent total or subtotal thyroidectomy due to PTC from 2012 to 2019 were reviewed. The clinico-pathological features of participants, such as age, gender, tumor stage, tumor size, lymph node involvement, metastasis, capsular invasion, single or multi-focal tumor status, and survival time were recorded from their medical records and pathology report and compared in two groups with and without Hashimoto’s thyroiditis. Results: From 251 participants, 92 (36.6%) had Hashimoto’s thyroiditis, whereas 159 (63.4%) did not show any signs of this disease. Fifteen participants in the Hashimoto group and 46 in the non-Hashimoto group had a recurrence. Although there were no significant differences between the two groups in the term of recurrence rate (P = 0.08), the mean survival time was significantly difference between the two groups (69.03 and 58.78, respectively; P = 0.038) Conclusions: Results of the study revealed that Hashimoto’s thyroiditis could increase the survival time of patients with PTC.
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Chen, Si, Yan Peng, Hao Zhang, and Yandun Zou. "Relationship between thyroid function and dietary inflammatory index in Hashimoto thyroiditis patients." Medicine 102, no. 46 (2023): e35951. http://dx.doi.org/10.1097/md.0000000000035951.
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Inflammation is closely related to the changes of thyroid function in Hashimoto thyroiditis patients. Certain nutrients or dietary habits can alter the levels of autoantibodies in Hashimoto thyroiditis. However, it remains unclear whether dietary inflammation affects thyroid function in patients with Hashimoto thyroiditis. The purpose of this study was to assess the relationship between dietary inflammation and thyroid function in Hashimoto thyroiditis patients using data from the National Health and Nutrition Examination Survey. We employed weighted multivariable linear regression, subgroup analyses, and interaction analysis to explore the relationship between thyroid function and dietary inflammatory index. We found that dietary inflammatory index was positively correlated with TSH and total T4. Interaction analysis found an interaction between urinary iodine concentration and FT3, but subgroup analysis for different levels of urinary iodine concentration did not get statistically significant results. Hashimoto thyroiditis patients with more pro-inflammatory diet habits had higher levels of TSH and TT4. In order to prevent hypothyroidism more effectively in patients with Hashimoto thyroiditis, it is essential to control dietary inflammation. However, it is still necessary to design a better prospective cohort study to verify the causal relationship.
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Almahari, Sayed Ali, Reem Maki, Noor Al Teraifi, Safa Alshaikh, Nisha Chandran, and Husain Taha. "Hashimoto Thyroiditis beyond Cytology: A Correlation between Cytological, Hormonal, Serological, and Radiological Findings." Journal of Thyroid Research 2023 (June 19, 2023): 1–8. http://dx.doi.org/10.1155/2023/5707120.
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Introduction. Hashimoto thyroiditis is the most common cause of chronic inflammation of the thyroid gland. Ultrasound is the modality for detection, while fine needle aspiration is the gold standard method for diagnosis. Serologic markers, such as antithyroidal peroxidase antibody (TPO) and antithyroglobulin antibody (TG), are usually elevated. Aim. The main objective is to appraise the incidence of neoplasms on a background of Hashimoto thyroiditis. Our second objective is to recognize the different sonographic appearances of Hashimoto thyroiditis, to focus on its nodular and focal patterns, and to measure the sensitivity of the ACR TIRAD system (2017) when interpreted on patients with Hashimoto thyroiditis. Methods. A single-center retrospective cross-sectional study. We studied 137 cases diagnosed cytologically as Hashimoto thyroiditis from January 2013–December 2019. The data collected were analyzed using SPSS (26th edition), and ultrasounds were reviewed by a single board-certified radiologist. The ACR thyroid imaging and Data System 2017 (ACR TI-RADs 2017) and the Bethesda System for reporting thyroid cytology 2017 (BSRTC 2017) were used for reporting ultrasound and cytology, respectively. Results. The mean age was 44.66 years and the female : male was 9 : 1. Serologically, anti-Tg was high in 22 cases (38%), while anti-TPO was positive in all of the 60 cases studied. Histologically, 11 cases were diagnosed with papillary thyroid carcinoma (8%) and a single case with follicular adenoma (0.7%). Ultrasonographically, 50% of the cases showed diffuse pattern, in which 13% of them showed micronodules. 32.2% were macronodular, and 17.7% were a focal nodular pattern. 45 nodules were interpreted with the ACR TIRAD system (2017), in which 22.2% were TR2, 26.6% were TR3, 17.7% were TR4, and 33.3% were TR5. Conclusion. Hashimoto thyroiditis is a risk factor for developing thyroid neoplasms, which necessitate a proper assessment of the cytological material studied and a correlation with the clinical and radiological features. Recognizing the different types of Hashimoto thyroiditis and its variable appearances is significantly important in performing and interpreting thyroid ultrasound imaging. Microcalcification is the most sensitive parameter to discriminate between PTC and nodular type of Hashimoto thyroiditis. The TIRAD system (2017) is a useful tool for risk stratification; however, it might create unnecessary FNA studies in the setting of Hashimoto thyroiditis because of its variable appearances on ultrasound. A modified TIRAD system for patients with Hashimoto thyroiditis is important to alleviate this confusion. Finally, anti-TPO is a sensitive marker for detecting Hashimoto thyroiditis, which could be used for future referencing of newly diagnosed cases.
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Hapsari, Siti Nurul, and Sidarti Soehita. "Hyperthyroid Phase of Hashimoto's Thyroiditis." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 26, no. 1 (2019): 123. http://dx.doi.org/10.24293/ijcpml.v26i1.1779.
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Hashimoto thyroiditis (chronic autoimmune thyroiditis) is the most common cause of hypothyroidism in iodine-sufficient areas of the world. This condition, however, can sometimes show hyperthyroidism. A 39-year-old femalewas admitted to hospital due to shortness of breath and tremor four hours before hospitalization. There were nausea, chestpain, cold chills, and palpitation. She was diagnosed with Hashimoto's thyroiditis and routinely received tyrosol,propranolol, and dexamethasone. Physical examination showed cervical mass, afebrile, blood pressure of 130/70 mmHg,pulse rate of 110 beats/minute and respiratory rate of 20 breaths/minute. Laboratory examinations showed WBC 7.53 x 109/L, Hb 11.0 g/dL and platelet count of 168 x 109/L. Chest X-Ray: negative for infiltrates. Several laboratory testswere performed, abnormal results were as follows: FT4 level of 2.96 ng/dL (increased), TSH level of 0.003 µIU/mL(decreased), anti-TPO (antithyroid microsomal antibody) level of 306 IU/ml (increased), and IgE level of 213.6 IU/mL(increased). Peripheral blood smear, coagulation test, serum electrolytes, liver function tests, renal function tests, urinalysis,CEA and Ca 125 were within normal limits. Thyroid ultrasound was performed and showed a benign lesion. Fine needleaspiration biopsy showed lymphocytic Hashimoto's thyroiditis. Echocardiography showed hyperthyroid heart disease. Dueto an increase of anti-TPO and FT4 levels, a decrease of TSH levels and lymphocytic thyroiditis from FNAB, this patient wasdiagnosed with a hyperthyroid phase of Hashimoto's thyroiditis. Thyroid function tests and thyroid antibody tests must bemonitored to distinguish between the hyperthyroid and hypothyroid phase of Hashimoto thyroiditis.
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Jabeen, Sumerah, and Muhammad Qamar Masood. "SUBACUTE THYROIDITIS EVOLVING INTO HASHIMOTO THYROIDITIS." AACE Clinical Case Reports 4, no. 4 (2018): e297-e299. http://dx.doi.org/10.4158/accr-2017-0118.
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Slijepčević, Nikola, Branislav Oluić, Božidar Odalović, Milan Grujić, and Vladan Živaljević. "Risk factors and survival rate for primary thyroid lymphoma: A case-control study." Medicinska istrazivanja 56, no. 3 (2023): 35–41. http://dx.doi.org/10.5937/medi56-43866.
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Aim. The aim of the study was to evaluate demographic and clinical characteristics of patients with primary thyroid lymphoma (PTL), to identify risk factors associated with PTL and determine overall survival. Methods. We performed a retrospective case-control study of patients operated for PTL from 1995 to 2017. There were 41 patients with PTL who formed the cases group. The control group consisted of 82 patients with Hashimoto thyroiditis without concurrent thyroid disease. In statistical analysis we used standard descriptive statistics, logistic regression analysis, Kaplan-Meier survival curves and log rank test. Results. In the cases group there were 35 patients with non-Hodgkin lymphoma and six patients with Hodgkin lymphoma. The cases group and the control group had a predominantly female population (>90%). In the control group nearly 70% of patients were younger than 55 years, while in the cases group over 60% of patients were older than 55 years. Risk factors for the development of PTL in patients with Hashimoto thyroiditis are older age, long standing Hashimoto thyroiditis, elevated level of TSH and a suspicious FNAB finding. Independent risk factors for PTL are older age (>55 years) and long standing Hashimoto thyroiditis (>10 years). The mean overall survival for patients with PTL is 92.8 months. Patients with longstanding Hashimoto thyroiditis have a shorter survival (84 month). Conclusion. Patients older than 55 years with longstanding Hashimoto thyroiditis have a higher risk of developing PTL. Additionally, patients with longstanding Hashimoto thyroiditis have worse prognosis compared to other patients with PTL.
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Daniluk, Aleksander, Kaja Iwaniuk, Martyna Wojda, Magdalena Świstowska, and Aleksandra Wielgosz. "Gut microbiota and thyroid diseases – summary of current knowledge." Quality in Sport 16 (July 10, 2024): 52770. http://dx.doi.org/10.12775/qs.2024.16.52770.
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Introduction and purpose: The gut microbiota is a diverse collection of microorganisms that coexist in the human intestine. Disorders in its structure leads to dysregulation of huge number of organs, including the thyroid. This review summarizes the latest findings regarding the links between gut microbiota and common thyroid diseases: Hashimoto's thyroiditis, Graves' disease and thyroid cancer. Materials and methods: This review was based on the PubMed and Google Scholar databases, using keywords: „gut microbiota AND thyroid/Hashimoto/Graves/thyroid cancer”, „Graves’ disease”, ,,Hashimoto thyroiditis”. Description of knowledge: Gut dysbiosis can contribute to autoimmune thyroid diseases by influencing micronutrient availability and immune regulation. Specific bacterial species may impact Hashimoto's development by regulating neurotransmitters and hormone secretion. In Graves' disease, significant changes in gut microbiota suggest their potential role in autoimmune processes. Research on gut microbiota in thyroid cancer suggests potential diagnostic tools and implicates gut microbiota alterations in tumor development. Conclusions: Significant gut microbiota changes are observed in Hashimoto's thyroiditis, Graves' disease, and thyroid cancer compared to healthy individuals, indicating a possible association. However, the exact mechanisms remain unclear, necessitating further research to understand how microbiota alterations contribute to these diseases.
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Shisilia, Mitra Novita, Wironegoro Rio, and Fauziah Dyah. "The clinical, laboratory and anatomical pathology profiles of Hashimoto's Thyroiditis patients at Dr. Soetomo General Academic Hospital Surabaya 2015 – 2020." World Journal of Advanced Research and Reviews 16, no. 3 (2022): 518–25. https://doi.org/10.5281/zenodo.7902912.
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The primary cause of hypothyroidism in the sufficient iodine area is Hashimoto's thyroiditis. Hashimoto's thyroiditis, also known as chronic autoimmune thyroiditis or chronic lymphocytic thyroiditis, is an autoimmune condition in which B cells and T cells slowly destroy the thyroid gland. To determine the diagnosis, we need the clinical, laboratory, cytological, and/or histopathology profiles. It aims to distinguish Hashimoto's thyroiditis from other diseases such as nontoxic goiter and Graves' disease. This retrospective descriptive study used data from the medical record of Dr. Soetomo General Hospital from 2015-2020. This study used total sampling and got 18 patients in total. The patients were mostly females (<em>n</em>=15), in the age group of 40-49 years old (<em>n</em>=8). The main complaint was an enlargement or nodule in the neck. The TSH (thyroid stimulating hormone) levels were majorly higher than the normal range (<em>n</em>=8) meanwhile the FT4 levels were mostly normal (<em>n</em>=6) and low (<em>n</em>=6). The positivity of TPOAb (antibody against thyroid peroxidase) is merely found in one patient. The majority of the result of the Doppler ultrasound examinations revealed Hashimoto’s thyroiditis (<em>n</em>=7). FNAB (fine needle aspiration biopsy) was performed on 11 patients. A histopathology examination was also conducted on 9 patients who underwent thyroidectomy. All of the cytology and histopathology examinations confirmed Hashimoto’s thyroiditis. Non-Hodgkin Lymphoma was found to coexist with 2 Hashimoto's thyroiditis cases. The findings were similar to the previous studies, except that among all the subjects, those who are 40-49 in age were primarily found in this study.
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Zhang, Qihong, and Xiabin Lan. "Assessment of causal association between autoimmune thyroiditis and thyroid cancer: A Mendelian randomization study." Medicine 104, no. 9 (2025): e41633. https://doi.org/10.1097/md.0000000000041633.
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Currently, the precise interplay between autoimmune thyroiditis, particularly Hashimoto thyroiditis, and thyroid cancer remains ambiguous. While certain observational studies suggest autoimmune thyroiditis (including Hashimoto thyroiditis) as a predisposing factor for thyroid cancer. Nevertheless, it is still uncertain whether autoimmune thyroiditis is independently associated with thyroid cancer. We employed Mendelian randomization (MR) study methodology, a genetic analysis approach, to evaluate the causal impact of autoimmune thyroiditis on the occurrence of thyroid cancer. We obtained and synthesized statistical data by utilizing public available genome-wide association studies (GWAS). Our study utilized GWAS summary statistics datasets associated with autoimmune thyroiditis (including Hashimoto thyroiditis) as the exposure data source and selected GWAS summary statistics datasets related to thyroid cancer as the outcome data source. Single nucleotide polymorphisms closely associated with autoimmune thyroiditis were chosen as instrumental variables. We conducted 2-sample MR analyses to elucidate the causal association between autoimmune thyroiditis and thyroid cancer. The inverse variance-weighted (IVW) method was employed as the primary methodology, supplemented by additional MR methods including MR-Egger regression, weighted median, simple mode, and weighted mode analyses, to bolster the robustness of our findings. The MR analysis conducted using the IVW method did not confirm a causal relationship between autoimmune thyroiditis and thyroid cancer (odds ratio [OR] = 0.8554, 95% confidence interval [CI]: 0.7193 to 1.0172, P = .0772; OR = 0.8477, 95% CI: 0.7159 to 1.0039, P = .0555; and OR = 1.1324, 95% CI: 0.9342 to 1.3725, P = .2052, from 3 eligible dataset analyses, respectively). Additionally, MR analysis did not observe a causal association between Hashimoto thyroiditis and thyroid cancer (OR = 1.0449, 95% CI: 0.9400 to 1.1615, P = .4155; and OR = 0.9897, 95% CI: 0.8174 to 1.1984, P = .9159, from 2 eligible dataset analyses, respectively). Consistency in results across alternative MR methods was observed. This study employing MR methodology indicates the absence of significant causal relationship between exposure to autoimmune thyroiditis (including Hashimoto thyroiditis) and thyroid cancer. Further validation through larger-scale studies with increased sample sizes is warranted in future investigations.
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Pyzik, Aleksandra, Ewelina Grywalska, Beata Matyjaszek-Matuszek, and Jacek Roliński. "Immune Disorders in Hashimoto’s Thyroiditis: What Do We Know So Far?" Journal of Immunology Research 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/979167.
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This review of literature attempts to identify the factors that are involved in the pathogenesis of Hashimoto thyroiditis, an immune defect in an individual with genetic susceptibility accompanied with environmental factors. The frequency of Hashimoto’s disease is a growing trend and among Caucasians it is estimated at approximately 5%. The dysfunction of the gland may be clinically evident (0.1–2% of the population) or subclinical (10–15%). The pathology is diagnosed five to ten times more often in women than men and its incidence increases with the age (the peak of the number of cases is between 45 and 65); however, it can also be diagnosed in children. The pathogenesis of Hashimoto’s thyroiditis is still not fully comprehended. In the etiology of Hashimoto thyroiditis excessively stimulated T CD4+ cells are known to play the most important role. Recent research has demonstrated an increasing role of newly discovered cells such as Th17 (CD4+IL-17+) or T regulatory cells (CD4+CD25+highFoxP3+) in the induction of autoimmune disorders. The process of programmed cell death also plays an equally important role in the pathogenesis and the development of hypothyroidism.
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Espírito Santo, Raquel, Teresa Sabino, and Ana Agapito. "Oftalmopatia Tiroideia Severa e Tiroidite de Hashimoto, em Doente Eutiroideu." Acta Médica Portuguesa 29, no. 9 (2016): 572. http://dx.doi.org/10.20344/amp.7015.
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Atia, Ahmed, Rihan Alathream, and Abdulwahab Al-Deib. "Incidence of Hashimoto Thyroiditis Among Libyans: A Retrospective Epidemiological Study." Journal of Medical Research and Innovation 5, no. 1 (2021): e000251. http://dx.doi.org/10.32892/jmri.251.
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Background and aims. Hashimoto's disease is an autoimmune disorder in which the body produces antibodies that attack the thyroid gland, leading to chronic inflammation, destruction of the gland, and hypothyroidism. This study aimed to assess the epidemiology of this disease among Libyan patients. Methods. A cross-sectional retrospective study conducted from June 2012 to April 2020 in order to examine the anti TPO level among Libyan population. Data was collected from eastern and western part of Libya, and were analyzed from available sample for 244 apparently patients with thyroid disorders collected from different private clinic’s laboratories. The analysis for serum anti-TPO was done by electrochemiluminescence protein binding assay (ECLIA) using Roche diagnostics and Cobas e411 analyzer. Results. The current results showed that females predominate the study, and most of them were in the age group of (>40) years old. About 49.18% of these cases were suffering from Hashimoto's disease (High ATPO level). The mean value of anti-TPO status among females was (0.5±2) nmol/L, while among males it was (0.45±3) nmol/L. Significantly, more women (81.66%) had Anti- TPO Above (34 IU/ml), compared to (18.33%) of male participants. Conclusion. Hashimoto disease is common among patients with thyroid dysfunction especially females. Our findings suggest that different interventional strategies are needed to reduce the chances of developing Hashimoto’s and its associated negative health outcomes in Libya.
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Jagodzinska, Julia, Renata Polaniak, Ewa Birkner, and Alicja Kasperska-Zajac. "Analysis of Circulating Vascular Endothelial Growth Factor and Its Soluble Receptors in Patients with Different Forms of Chronic Urticaria." BioMed Research International 2015 (2015): 1–6. http://dx.doi.org/10.1155/2015/578383.
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Background. Vascular endothelial growth factor (VEGF) is a powerful enhancer of vascular permeability and inflammatory response; however its significance in chronic urticaria is poorly recognised.Aim. To compare free circulating levels of VEGF and its soluble receptors (sVEGFR1 and VEGFR2) in patients with different forms of chronic urticaria.Methods. The concentrations of VEGF and its receptors in plateletpoor plasma (PPP)/plasma were measured using enzyme-linked immunosorbent assay in chronic urticaria: (1) chronic spontaneous urticaria (CSU) with positive autologous serum skin test (ASST), (2) CSU with negative response to ASST, (3) CSU with concomitant euthyroid Hashimoto’s thyroiditis (CSU/Hashimoto), (4) delayed pressure urticaria (DPU), and the healthy subjects.Results. There were no significant differences in VEGF concentration in PPP between CSU groups and the healthy subjects. Contrary, VEGF concentration was significantly higher in DPU and CSU/Hashimoto patients as compared with the healthy subjects and CSU groups. Furthermore, VEGF value in CSU/Hashimoto patients during the remission was similar to that of the active period and significantly higher than the healthy subjects; VEGF concentration was significantly correlated with TSH. Plasma concentrations of sVEGF1 and sVEGF2 were similar in chronic urticaria patients and the healthy subjects.Conclusions. Increased free circulating VEGF concentration may result from the urticarial process itself as well as concomitant Hashimoto’s thyroiditis.
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Geetha, Karra, G. Sasanka, S. Pridvineel, Meraj Unnisa Banu, and T. Rama Rao. "A Review on Hashimoto’s Thyroiditis." Journal of Drug Delivery and Therapeutics 13, no. 12 (2023): 250–54. http://dx.doi.org/10.22270/jddt.v13i12.6133.
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Hashimoto's thyroiditis (HT) is an autoimmune thyroid disorder first described by Japanese physician Haraku Hashimoto in 1912 characterized by lymphocytic infiltration of the thyroid parenchyma and is influenced by immune system instability. The onset of autoimmunity may be influenced by innate and acquired immune responses. Thyroid autoantibodies (TAbs) are the primary biochemical feature. Epidemiological studies show AITD (autoimmune thyroid disease) risk is higher in women and is age-related. Risk factors include high iodine consumption, selenium insufficiency, infectious disorders, and specific medications. Genetic predisposition and environmental factors also contribute to HT. Pregnancy and sex steroids play a role in the development of autoimmune thyroiditis, with older women being more susceptible. The immune system is modified during pregnancy, with progesterone playing a significant role. About 20% of postpartum thyroiditis patients eventually develop HT. The symptoms include dysphonia, dyspnea, and dysphagia, with primary hypothyroidism causing greater systemic symptoms. Diagnosis involves circulating thyroid-specific antibodies, ultrasound examination, increased thyroid stimulating hormone, and normal serum thyroid hormone levels. Ultrasonography is crucial for diagnosing Hashimoto's thyroiditis, distinguishing it from other thyroid disorders like Graves' disease (GD). The treatment comprises levothyroxine, which effectively lowers thyroid volume, as well as vitamin D deficiency and replacement. Autoimmune thyroiditis (AIT) surgery has traditionally been reserved for people who have discomfort or compressive symptoms from goitre or co-existing malignant thyroid nodules. Thyroidectomy has lately been advocated as a treatment option for decreasing TPOAbs, as the presence of such antibodies is linked to a worse quality of life even in euthyroid patients.
 Keywords: Hashimoto’s thyroiditis (HT), Autoimmune thyroid disease (AITD), Autoimmune thyroiditis (AIT) Vitamin D , Levothyroxine
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Lygina, E. A., and V. V. Latyi. "Life and Heritage of Hakaru Hashimoto." Clinical and experimental thyroidology 17, no. 2 (2021): 20–23. http://dx.doi.org/10.14341/ket12562.
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In May 2021, the 140th anniversary of his birth is celebrated by Japanese doctor Hakaru Hashimoto. Did not receive recognition during his lifetime, this amazing scientist discovered a new disease of the thyroid gland, which later became the eponym. For a long time, his name was forgotten, but the main work of his life was decades ahead of the development of science. Without it, the study of autoimmune pathologies, the incidence of which currently continues to increase, would be impossible. It was on patients with Hashimoto’s thyroiditis that a study was conducted for the first time, demonstrating not only the uniqueness of the pathogenesis of thyroiditis, but also the existence of autoimmune reactivity of the body as a whole.
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Arsovska, Blagica, Jihe Zhu, and Kristina Kozovska. "CASE REPORT - ACUPUNCTURE TREATMENT IN MALE PATIENT WITH HASHIMOTO THYROIDITIS." International Journal of Research -GRANTHAALAYAH 7, no. 9 (2019): 288–91. http://dx.doi.org/10.29121/granthaalayah.v7.i9.2019.612.
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Hashimoto's thyroiditis is associated with the presence of anti-thyroid autoantibodies (anti-TPO). High serum antibodies are found in the active phases of chronic autoimmune thyroiditis. In many medical cases with Hashimoto’s thyroiditis it is possible to have high levels of anti-TPO antibodies and fT4, fT3 and TSH levels to be within the normal range. Most doctors believe that Hashimoto's thyroiditis is an incurable form of thyroid deficiency. With the TCM treatment the patient’s strength and vitality can be improved, the Qi flow can be harmonized, nourished and strengthened and the body’s system can be repaired and recharged so the patient may go into remission. The treated patient is 44 year old man, diagnosed with Hashimoto’s thyroiditis caused by stress. The patient has done 40 acupuncture treatments within 21 months, once a week. The patient wasn’t taking any additional hormonal medications. The parameters for fT4, fT3 and TSH were showing normal levels and the anti-TPO levels were increased. Before the treatment the anti-TPO antibodies amount was 252.4 IU/ml and after the treatment 4.07 IU/ml (normal <80 IU/ml). Treated points are: BL15 (XinShu), BL20 (PiShu), BL23 (ShenShu), DU4 (MingMen), DU14 (DaZhui), DU20 (BaiHui), ST9 (RenYing), LI4 (HeGu), KI3 (TaiXi), GB20 (FengChi), RN4 (QuanYuan), RN6 (QiHai), LR2 (TaiChong), SP9 (YinLingQuan), SP6 (SanYinJiao), ST36 (ZuSanLi) and Ashi points located on the neck (front and back).
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Waliszewska-Prosół, Marta, and Maria Ejma. "Hashimoto Encephalopathy—Still More Questions than Answers." Cells 11, no. 18 (2022): 2873. http://dx.doi.org/10.3390/cells11182873.
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The normal function of the nervous system is conditioned by the undisturbed function of the thyroid gland and its hormones. Comprehensive clinical manifestations, including neurological disorders in Hashimoto’s thyroiditis, have long been understood and, in recent years, attention has been paid to neurological symptoms in euthyroid patients. Hashimoto encephalopathy is a controversial and poorly understood disease entity and the pathogenesis of the condition remains unclear. We still derive our understanding of this condition from case reports, but on the basis of these, a clear clinical picture of this entity can be proposed. Based on a review of the recent literature, the authors present the current view on the subject, discuss controversies and questions that still remain unanswered, as well as ongoing research in this area and the results of our own work in patients with Hashimoto’s thyroiditis.
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Anderson, Lauren, William D. Middleton, Sharlene A. Teefey, et al. "Hashimoto Thyroiditis: Part 1, Sonographic Analysis of the Nodular Form of Hashimoto Thyroiditis." American Journal of Roentgenology 195, no. 1 (2010): 208–15. http://dx.doi.org/10.2214/ajr.09.2459.
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Deutsch, Melanie, John Koskinas, Konstatinos Tzannos, et al. "Hashimoto Encephalopathy with Pegylated Interferon Alfa-2b and Ribavirin." Annals of Pharmacotherapy 39, no. 10 (2005): 1745–48. http://dx.doi.org/10.1345/aph.1g144.
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OBJECTIVE: To report an instance of Hashimoto encephalopathy probably resulting from pegylated interferon alfa-2b and ribavirin. CASE SUMMARY: A 36-year-old woman with a 10-year history of autoimmune thyroiditis presented with symptoms and signs consistent with Hashimoto encephalopathy during therapy with pegylated interferon alfa-2b and ribavirin for chronic hepatitis C. DISCUSSION: Hashimoto encephalopathy is a rare autoimmune condition that occurs in patients with Hashimoto thyroiditis and high titers of antithyroid antibodies. It is characterized by a variety of nonspecific neuropsychiatric symptoms, increased cerebrospinal fluid protein level, and abnormal brain imaging and electroencephalogram. Prompt response to corticosteroids is observed in most cases. As of August 29, 2005, this is the first report of such an association. An objective causality assessment revealed that the Hashimoto encephalopathy was probably caused by the patient's medications. CONCLUSIONS: Hashimoto encephalopathy may rarely be triggered by interferon alfa therapy in susceptible patients.
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MONISHA S M, BABIKER BASHIR HAROUN BARAKA, YADAV V, ANKITH V, ANKITHA GAURAV, and NIVEDITHA G. "Levothyroxine management in Hashimoto’s thyroiditis: A comprehensive revie." International Journal of Science and Research Archive 12, no. 2 (2024): 847–53. http://dx.doi.org/10.30574/ijsra.2024.12.1.0856.
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Hashimoto thyroiditis and hypothyroidism are related thyroid conditions with different aetiologies and clinical manifestations. Insufficient synthesis of thyroid hormones causes hypothyroidism, which may lead to systemic symptoms that impact energy, metabolism, and overall wellness. Thyroid tissue damage mediated by the immune system is the hallmark of the autoimmune thyroid condition known as Hashimoto thyroiditis, which is the most prevalent cause of hypothyroidism. A wide range of symptoms, such as fatigue, weight gain, cold sensitivity, constipation, dry skin, and cognitive impairment, are clinical indications of hypothyroidism and Hashimoto thyroiditis. Thyroid function tests, which measure serum levels of free thyroxine, thyroid-stimulating hormone, and thyroid autoantibodies, must be performed for the diagnosis. Imaging techniques, such ultrasonography, may aid with nodular changes detection and thyroid morphology assessment. The goals of management plans for Hashimoto thyroiditis and hypothyroidism are to stop complications, relieve symptoms, and return the body to normal. The cornerstone of treatment is levothyroxine-based thyroid hormone replacement medication, which is customized for each patient depending on their clinical presentation and thyroid function testing. Dietary restrictions, patient education, and lifestyle changes are essential components of illness management.
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Ito, Hiroshi. "Acute exacerbation of Hashimoto thyroiditis mimicking subacute thyroiditis." Visual Journal of Emergency Medicine 37 (October 2024): 102120. http://dx.doi.org/10.1016/j.visj.2024.102120.
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Ucan, Bekir, Mustafa Sahin, Muyesser Sayki Arslan, et al. "Vitamin D Treatment in Patients with Hashimoto’s Thyroiditis may Decrease the Development of Hypothyroidism." International Journal for Vitamin and Nutrition Research 86, no. 1-2 (2016): 9–17. http://dx.doi.org/10.1024/0300-9831/a000269.
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Abstract.The relationship between Hashimoto’s thyroiditis and vitamin D has been demonstrated in several studies. The aim of the present study was to evaluate vitamin D concentrations in patients with Hashimoto’s thyroiditis, the effect of vitamin D therapy on the course of disease, and to determine changes in thyroid autoantibody status and cardiovascular risk after vitamin D therapy. We included 75 patients with Hashimoto’s thyroiditis and 43 healthy individuals. Vitamin D deficiency is defined as a 25-hydroxy vitamin D (25(OH)D3) concentration less than 20ng/mL. Vitamin D deficient patients were given 50.000 units of 25(OH)D3 weekly for eight weeks in accordance with the Endocrine Society guidelines. All evaluations were repeated after 2 months of treatment. Patients with Hashimoto’s thyroiditis had significantly lower vitamin D concentrations compared with the controls (9.37±0.69 ng/mL vs 11.95±1.01 ng/mL, p < 0.05, respectively). Thyroid autoantibodies were significantly decreased by vitamin D replacement treatment in patients with euthyroid Hashimoto’s thyroiditis. Also, HDL cholesterol concentrations improved in the euthyroid Hashimoto group after treatment. The mean free thyroxine (fT4) concentrations were 0.89±0.02 ng/dL in patients with Hashimoto’s thyroiditis and 1.07±0.03 ng/dL in the healthy control group (p < 0.001). The mean thyroid volumes were 7.71±0.44 mL in patients with Hashimoto’s thyroiditis and 5.46±0.63 mL in the healthy control group (p < 0.01). Vitamin D deficiency is frequent in Hashimoto’s thyroiditis and treatment of patients with this condition with Vitamin D may slow down the course of development of hypothyroidism and also decrease cardiovascular risks in these patients. Vitamin D measurement and replacement may be critical in these patients.
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Abdul Khader and Bhagyashree Kamate. "Understanding and approach of Ayurveda management towards a unique case of Hashimoto Thyroiditis - A Case Report." Journal of Ayurveda and Integrated Medical Sciences 8, no. 12 (2024): 251–60. http://dx.doi.org/10.21760/jaims.8.12.38.
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Hashimoto thyroiditis is also known as chronic autoimmune thyroiditis and chronic lymphocytic thyroiditis, is an autoimmune disease in which thyroid cells are destroyed via cell and antibody-mediated immune processes. It is the most common cause of hypothyroidism in developed countries. The Pathophysiology of Hashimoto Thyroiditis involves the formation of antithyroid antibodies that attack the thyroid tissue, causing progressive fibrosis. The condition is sometimes not diagnosed until late in the disease process. The most common laboratory findings demonstrate elevated Thyroid-Stimulating Hormone (TSH) and low Thyroxine (T4) levels, coupled with increased anti thyroid peroxidase (anti-TPO) antibodies. In Ayurveda, it can be correlated with Rasavaha Sroto Vikara, Dhatwagnimandya, Vataja Pandu, Pittavruta Vata based on symptoms. Case Report: In this present study a female patient aged 37 years, known case of Hashimoto Thyroiditis since 8 years was treated with Shiro Takradhara, Sarvanga Abhynaga, Virechana and specific Shamanaushadhi’s as per signs and symptoms. Results: After 2 months of treatment there was a significant reduction in the signs and symptoms of the disease with 70% improvement in the condition.
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Jasim Abdullah, Younus, Rajwa Hasen Essa, and Misa Ghazi Jumaa. "Incidence of Hashimoto's thyroiditis and its relationship to age, sex, smoking and blood groups." NTU Journal of Pure Sciences 1, no. 2 (2022): 1–9. http://dx.doi.org/10.56286/ntujps.v1i2.175.
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This study was aimed to demonstrate the incidence of Hashimoto's disease in Iraqi patients and its correlation to some of the sociodemographic features. The research groups involved (50 patients with Hashimoto?s disease and 50 healthy subjects). All of them were subjected to the estimation of levels of free triiodothyronine (FT3), free thyroxine (FT4), TSH, anti-thyroid peroxidase (anti-TPO), and anti-thyroglobulin (anti-Tg). The results demonstrated that there is a dramatic increase in the occurrence of HT in older patients. The age group (41-50 years old) was the most age group affected by Hashimoto's disease, followed by the age groups (31-40, 21-30, and 9-20 years old) respectively. A significant proportional correlation (R:0.952, P:0.024) was found between HT disease and aging. According to the gender, the results found that the vast majority (82%) of patients were females (P = 0.01). Also, the smoking percent was (40%) of patients. The presence of autoimmune thyroid disease in one or more individuals within the family (family history) was also evaluated and the results found that (28%) of the Hashimoto?s disease group have a positive family history of thyroid autoimmune diseases. It can be concluded from these results that females are more prone to developing Hashimoto?s disease compared to males, in other words, the female gender is a risk factor for the occurrence of autoimmune hypothyroidism. Also, the negative impact of smoking and family history gives an indication that these parameters are independent and don’t associate with Hashimoto?s disease at least in the current study.
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Chiarella, Giuseppe, Diego Russo, Fabio Monzani, et al. "HASHIMOTO THYROIDITIS AND VESTIBULAR DYSFUNCTION." Endocrine Practice 23, no. 7 (2017): 863–68. http://dx.doi.org/10.4158/ep161635.ra.
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Shih, George, Wei-Jen Shih, Wen-Sheng Huang, and Primo P. Milan. "Hashimoto Thyroiditis and Takayasu Aortitis." Clinical Nuclear Medicine 33, no. 5 (2008): 377–79. http://dx.doi.org/10.1097/rlu.0b013e31816a796d.
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Ginaldi, Sergio. "Malignant Lymphoma in Hashimoto Thyroiditis." Journal of Computer Assisted Tomography 10, no. 6 (1986): 1071–72. http://dx.doi.org/10.1097/00004728-198611000-00041.
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Luboshitzky, Rafael, Leonid Chervinsky, Ghali Qupti, and Muralee Dharan. "Cytodiagnostic Accuracy of Hashimoto Thyroiditis." Endocrinologist 19, no. 2 (2009): 55–57. http://dx.doi.org/10.1097/ten.0b013e318198b766.
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Catalán, R., R. Rossell, J. Treserra, R. Sorio, M. J. Chinchilla, and C. Udina. "Mood disorders in hashimoto thyroiditis." Biological Psychiatry 42, no. 1 (1997): 111S. http://dx.doi.org/10.1016/s0006-3223(97)87351-9.
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Petek-Balci, Belgin, Vildan Yayla, and Feriha ??zer. "Multiple Sclerosis and Hashimoto Thyroiditis." Neurologist 11, no. 5 (2005): 301–4. http://dx.doi.org/10.1097/01.nrl.0000162956.40653.38.
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Rishi, Rahul, Sudip Ringwala, James Tracy, and Shahnaz Fatteh. "Prurigo nodularis and Hashimoto thyroiditis." Annals of Allergy, Asthma & Immunology 113, no. 6 (2014): 673–74. http://dx.doi.org/10.1016/j.anai.2014.09.010.
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Roychowdhury, Monika, and Stefan E. Pambuccian. "Hashimoto thyroiditis with crystalloid formation." Diagnostic Cytopathology 39, no. 12 (2010): 909–11. http://dx.doi.org/10.1002/dc.21536.
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Karki, S., and A. Shrestha. "Fine needle aspiration cytology of thyroid and its correlation with serological findings." Journal of Pathology of Nepal 7, no. 1 (2017): 1054–58. http://dx.doi.org/10.3126/jpn.v7i1.16777.
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Background: Thyroid autoimmunity can cause several forms of thyroid disorders i.e. Grave’s disease, Hashimoto’s thyroiditis, atrophic autoimmune thyroiditis, post-partum thyroidits etc. Cytological diagnosis may be sometimes difficult is some cases. In such conditions, cytology along with serological tests aid at reaching a correct diagnosis.Hence, this study was undertaken to evaluate the serum level of anti-TPO antibody with respect to serum concentrations of thyroid hormones and its importance in diagnosing autoimmune thyroiditis.Material and Methods: This study was carried out in the department of pathology from June 2013-May 2014. Patients coming to the department of pathology TUTH, Maharajgunj for FNA of thyroid were included. TFT level was noted and anti TPO antibody level was evaluated by CLIA.Results: Ninety-five thyroid FNAC was included in the study, which comprises of 16.8 % males and 83.2% females with a M: F 1: 4.9. Maximum number of cases was seen in the age range 21-30 years (25.3%), mean age being 40.4years. The cytological diagnosis comprised colloid goiter(43.2%), lymphocytic thyroiditis (25.3%), Hashimoto thyroiditis(18.9%). Out of 42 cases of autoimmune thyroiditis diagnosed cytologically, 16 (38%) were hypothyroid, 4 (9.5%) hyperthyroid, 8 (19%) sub-clinical hypothyroid and 14 (33.5%) were euthyroid. The sensitivity and specificity of positive anti TPO in correctly identifying autoimmune thyroiditis was 85.7% and 79.2% respectively. The positive and negative predictive value for the test was 76.5% and 87.5% respectively.Conclusion: Nodular goitre can harbour a certain per cent of autoimmune thyroiditis and in such cases anti TPO antibody level along with cytodiagnosis appears to be helpful.
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Swathi, Penki, Polisetty Satyanarayanarao, Kumar Komanapalli Sunil, Gunta Sirisha, Das Basumitra, and Kuna Rajani. "Study on Cytomorphological Spectrum of Hashimoto's Thyroiditis and to Evaluate the Correlation among Cytopathological Grading, Serum ATPO Levels and Biochemical Parameters in Tertiary Care Centre." International Journal of Pharmaceutical and Clinical Research 16, no. 1 (2024): 538–44. https://doi.org/10.5281/zenodo.11096033.
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<strong>Introduction:</strong> Hashimoto’s thyroiditis (HT) is an organ-specific autoimmune disease. Fine needle aspiration cytology is the safe and accurate method for diagnosis. Antithyroid peroxidase (ATPO) antibody titres correlate best with the degree of thyroidal lymphocytic infiltration. <strong>Objectives: </strong>This study was aimed to grading the thyroiditis and to correlate with clinical, biochemical and serum anti thyroid peroxidase levels. <strong>Materials and Methods: </strong>The present study is a prospective study and is conducted for a period of 1 year in our tertiary care centre. A total of 179 patients were referred for evaluation of thyroid lesions. We have included, newly diagnosed, those confirmed as having HT through FNAC (41 cases). ATPO, TSH were done for this study group. <strong>Results:</strong> Out of 70 HT cases ,41 cases met the inclusion criteria. In these 41 cases, 40 were females, age ranged from 11 years to 60 years, with majority of patients were in 4th decade. Majority of patients had cytomorphologically graded, grade 1 thyroiditis (21 cases), followed by grade 2(16 cases) and grade 3 (4 cases). ATPO was elevated in 38 cases. TSH was elevated in 6 cases. There was no obvious correlation between the cytological grades of thyroiditis and levels of anti-thyroid peroxidase antibody and TSH. <strong>Conclusion:</strong> Lymphocytic infiltration of the thyroid gland occurs much earlier than serological evidence in Hashimoto’s thyroiditis. Although elevated levels of ATPO levels strongly associated with Hashimoto’s thyroiditis there is no obvious correlation was observed between cytomorphological grades of thyroiditis and levels of ATPO and TSH. Hashimoto’s thyroiditis should be diagnosed by multidisciplinary approach.
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Dunne, Christopher, and Francesco De Luca. "Long-Term Follow-Up of a Child with Autoimmune Thyroiditis and Recurrent Hyperthyroidism in the Absence of TSH Receptor Antibodies." Case Reports in Endocrinology 2014 (2014): 1–4. http://dx.doi.org/10.1155/2014/749576.
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Hashitoxicosis is an initial, transient, hyperthyroid phase that rarely affects patients with Hashimoto thyroiditis. We present here an unusual case of a child with Hashimoto thyroiditis and recurrent hyperthyroidism. A 4 yr 6/12 old male was diagnosed by us with autoimmune subclinical hypothyroidism (normal free T4, slightly elevated TSH, and elevated TG antibody titer). Two years and 6/12 later he experienced increased appetite and poor weight gain; a laboratory evaluation revealed suppressed TSH, elevated free T4, and normal TSI titer. In addition, an I123thyroid uptake was borderline-low. A month later, the free T4 had normalized. After remaining asymptomatic for 3 years, the patient presented again with increased appetite, and he was found with low TSH and high free T4. Within the following 3 months, his free T4 and TSH normalized. At his most recent evaluation, his TSH was normal and the free T4 was borderline-high; the TG antibody titer was still elevated and the TSI titer was negative. To our knowledge, this is the first patient reported with Hashimoto thyroiditis and recurrent hyperthyroidism. This case exemplifies the variability of the manifestations and natural history of Hashimoto thyroiditis and supports the need for a long-term evaluation of patients with autoimmune thyroid disease.
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Boz, Pinar Bengi, Muhammet Ateş, and Murat Boz. "Evaluation of visual evoked potentials in patients with Hashimoto thyroiditis." Ideggyógyászati szemle 78, no. 5-6 (2025): 181–88. https://doi.org/10.18071/isz.78.0181.
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Background and purpose – Our aim was to use visual evoked potentials (VEP) to evaluate changes in brain bioelectrical activity in Hashimoto thyroiditis patients with normal neurological examination and imaging findings and to correlate the evoked potential parameters with clinical data. Methods – The study included 75 clinically diagnosed Hashimoto thyroiditis patients and 45 healthy individuals who met the selection criteria. Demographic and clinical characteristics such as age, sex, disease duration, serum thyroid hormone levels, autoantibody titers, thyroid ultrasonography, brain magnetic resonance imaging, and levothyroxine dose used were recorded. VEP tests were performed in both groups. All participants provided informed consent. Results – Of the Hashimoto thyroiditis patients included in the study, 92% (n=69) were female, the mean age was 40.3±12.2 years, and the mean disease duration was 5.7±7.5 years (range: 0-40 years, median: 4 years). Euthyroid patients showed significantly longer P100 latency difference and higher N75/P100 amplitude than the control group (p=0.014 and 0.007, respectively). Elevated thyroid-stimulating hormone level was associated with longer N75 and P100 latencies. Conclusion – Our results demonstrated the presence of abnormal brain bioelectric activity in Hashimoto thyroiditis patients without active neurological findings. These effects increase with disease severity and duration and necessitate the development of early treatment strategies to halt the progressive autoimmune process.
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Sabina, Rafig Guliyeva, Eyvaz Guliyeva Firangiz, Azizulla Abiyev Huseyn, and Rufat Rahimova Rana. "Autoimmune thyroid diseases and genetic factors." World Journal of Advanced Research and Reviews 16, no. 1 (2022): 690–96. https://doi.org/10.5281/zenodo.7771692.
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The autoimmune thyroid condition with the highest prevalence is Hashimoto's thyroiditis (HT). Autoimmune thyroid diseases (AITD), including Graves’ disease (GD) and Hashimoto’s thyroiditis, arise due to complex interactions between environmental and genetic factors. Each is presenting with distinct clinical features. Significant progress has been made in our understanding of the mechanisms leading to AITD. Because of the complex nature of AITD, caused by their polygenic nature and a complex mode of inheritance, there are still more questions to be answered than answers that can be given, especially about the nature of Hashimoto’s thyroiditis. One of the cornerstones to understanding illness pathophysiology and creating better treatments is figuring out the genetic component of AITD. Common HT and GD genes have been identified, as well as genes that are characteristic of only one of those diseases.
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Morais, Ana, Marta Resende, and José Pereira. "Tireoidite de Hashimoto e Doença Periodontal: Uma Revisão Narrativa." Acta Médica Portuguesa 29, no. 10 (2016): 651. http://dx.doi.org/10.20344/amp.6704.
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Introduction: Currently there is a growing interest in studying systemic conditions with impact on the periodontium. The aim of this article is to determinate if there is a relation between Hashimoto’s thyroiditis and periodontal disease.Material and Methods: Founded on periodontology based on evidence and in the combination of the keywords: ‘Hashimoto disease’; ‘Hypothyroidism’; ‘Periodontal disease’; ‘Systemic Diseases’; a search and evaluation of articles was conducted in Medline, Scopus and Thomson Reuters databases, selecting 30 articles for integral analysis.Results: There have been developed several studies, searching for a better comprehension about the complexity and pathogenesis of periodontal diseases, associated them to multiple systemic conditions. Actually, the relationship that is best described in the literature is the one with rheumatoid arthritis; however, other relations have been pointed, such as Hashimoto’s thyroiditis.Discussion: The identification of multiple etiopathogenic mechanisms common to Hashimoto’s thyroiditis and periodontal disease allow to suspect of a relation between them. Some of these mechanisms include the proliferation of lymphocytes T helper 1 and T helper 17 and their impact on the periodontium, the dysfunction of vascular endothelium in gingival microcirculation and the influence of hypothyroidism on bone metabolism, namely on the alveolar bone.Conclusion: There is biological plausibility to support the establishment of an association between Hashimoto’s thyroiditis and periodontal disease. However, there are not enough studies to support the existence of a causal nexus between these two pathologies, so, in the future, more studies should be conducted to determinate there relation and interaction.
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Blagica, Arsovska, Zhu Jihe, and Kozovska Kristina. "CASE REPORT - ACUPUNCTURE TREATMENT IN MALE PATIENT WITH HASHIMOTO THYROIDITIS." International Journal of Research - Granthaalayah 7, no. 9 (2019): 288–91. https://doi.org/10.5281/zenodo.3473167.
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Hashimoto's thyroiditis is associated with the presence of anti-thyroid autoantibodies (anti-TPO). High serum antibodies are found in the active phases of chronic autoimmune thyroiditis. In many medical cases with Hashimoto’s thyroiditis it is possible to have high levels of anti-TPO antibodies and fT4, fT3 and TSH levels to be within the normal range. Most doctors believe that Hashimoto's thyroiditis is an incurable form of thyroid deficiency. With the TCM treatment the patient’s strength and vitality can be improved, the Qi flow can be harmonized, nourished and strengthened and the body’s system can be repaired and recharged so the patient may go into remission. The treated patient is 44 year old man, diagnosed with Hashimoto’s thyroiditis caused by stress. The patient has done 40 acupuncture treatments within 21 months, once a week. The patient wasn’t taking any additional hormonal medications. The parameters for fT4, fT3 and TSH were showing normal levels and the anti-TPO levels were increased. Before the treatment the anti-TPO antibodies amount was 252.4 IU/ml and after the treatment 4.07 IU/ml (normal <80 IU/ml). Treated points are: BL15 (XinShu), BL20 (PiShu), BL23 (ShenShu), DU4 (MingMen), DU14 (DaZhui), DU20 (BaiHui), ST9 (RenYing), LI4 (HeGu), KI3 (TaiXi), GB20 (FengChi), RN4 (QuanYuan), RN6 (QiHai), LR2 (TaiChong), SP9 (YinLingQuan), SP6 (SanYinJiao), ST36 (ZuSanLi) and Ashi points located on the neck (front and back).
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Ataee, Zahra, Saeed Shokoohi-rad, and Saman Soleimanpour. "A 10-year-old girl with red eyes and hypothyroidism." Journal of Emergency Practice and Trauma 8, no. 2 (2022): 166–69. http://dx.doi.org/10.34172/jept.2022.17.
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Objective: Hypothyroidism has many causes and manifestations in children. One of the causes is autoimmunity, which is known as autoimmune thyroiditis or Hashimoto thyroiditis. Pseudotumor cerebri is a rare manifestation of Hashimoto thyroiditis. Here we report a 10-year-old girl with asymptomatic papillary edema who was treated with levothyroxine and acetazolamide. Case Presentation: A 10-year-old girl suffered from left eye trauma while playing volleyball and went to an ophthalmology center due to redness in the same eye. During the examination, they noticed a bilateral optic disc swelling without ocular inflammation and the other eye examination was within normal limits. Encephalopathy may rarely occur during autoimmune thyroiditis, which is known as Hashimoto encephalopathy, and it is stated that the autoimmune disorder is not related to the thyroid dysfunction characterized by the symptoms of decreased level of consciousness and seizures. Conclusion: The diagnosis of hypothyroidism in children is usually made by examining the thyroid-stimulating hormone (TSH), and T4 in which TSH is elevated and T4 is decreased as in our patient.
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Włochal, Małgorzata, Marcin A. Kucharski, and Marian Grzymisławski. "The effects of vitamins and trace minerals on chronic autoimmune thyroiditis." Journal of Medical Science 83, no. 2 (2014): 167–72. http://dx.doi.org/10.20883/medical.e63.
Full textAbstract:
Hashimoto’s thyroiditis (HT), also known as chronic lymphocytic thyroiditis is one of the most frequent types of inflammation of the thyroid gland. The prevalence of the overt HT is about 2% but it is believed that Hashimoto thyroiditis is more frequent than expected. Hashimoto’s thyroiditis is characterized by dysfunction of the immune system, which leads to impaired tolerance of own tissues and increased production of autoantibodies against the thyroid cells. Thyroid peroxidase antibodies (anti-TPO), thyroglobulin antibodies (anti-Tg) and/or TSH receptors antibodies are the principal markers of the disease. The essential element of the treatment of HT is the supplementation of L-thyroxine. In Hashimoto’s disease, like in many other autoimmune diseases, researchers attempted to support pharmacological treatment by adequate nutrition. The aim of this paper was to review the existing literature on the levels of antioxidants (vitamin A, C, E, selenium, zinc) and vitamin D in patients with HT, as well as the influence of the nutritional supplementation of the above mentioned elements on the metabolism of the thyroid gland hormones and the level of anti-thyroid peroxidase (anti-TPO) antibodies.