Relevant bibliographies by topics / HAT Activators

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'HAT Activators'

Author: Grafiati
Published: 3 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "HAT Activators"

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Carrozza, Michael J., Sam John, Alok Kumar Sil, James E. Hopper, and Jerry L. Workman. "Gal80 Confers Specificity on HAT Complex Interactions with Activators." Journal of Biological Chemistry 277, no. 27 (2002): 24648–52. http://dx.doi.org/10.1074/jbc.m201965200.

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Peng, Guang-Hua, and Shiming Chen. "Crx activates opsin transcription by recruiting HAT-containing co-activators and promoting histone acetylation." Human Molecular Genetics 16, no. 20 (2007): 2433–52. http://dx.doi.org/10.1093/hmg/ddm200.

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Selvi, B. Ruthrotha, Jean-Christophe Cassel, Tapas K. Kundu, and Anne-Laurence Boutillier. "Tuning acetylation levels with HAT activators: Therapeutic strategy in neurodegenerative diseases." Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1799, no. 10-12 (2010): 840–53. http://dx.doi.org/10.1016/j.bbagrm.2010.08.012.

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Chen, Chi-Ju, Zhong Deng, Alex Y. Kim, Gerd A. Blobel, and Paul M. Lieberman. "Stimulation of CREB Binding Protein Nucleosomal Histone Acetyltransferase Activity by a Class of Transcriptional Activators." Molecular and Cellular Biology 21, no. 2 (2001): 476–87. http://dx.doi.org/10.1128/mcb.21.2.476-487.2001.

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ABSTRACT The transcriptional coactivator CREB binding protein (CBP) possesses intrinsic histone acetyltransferase (HAT) activity that is important for gene regulation. CBP binds to and cooperates with numerous nuclear factors to stimulate transcription, but it is unclear if these factors modulate CBP HAT activity. Our previous work showed that CBP interacts with the Epstein-Barr virus-encoded basic region zipper (b-zip) protein, Zta, and augments its transcriptional activity. Here we report that Zta strongly enhances CBP-mediated acetylation of nucleosomal histones. Zta stimulated the HAT acti
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Hassan, Ahmed H., Salma Awad, Zeina Al-Natour, Samah Othman, Farah Mustafa, and Tahir A. Rizvi. "Selective recognition of acetylated histones by bromodomains in transcriptional co-activators." Biochemical Journal 402, no. 1 (2007): 125–33. http://dx.doi.org/10.1042/bj20060907.

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Bromodomains are present in many chromatin-associated proteins such as the SWI/SNF and RSC chromatin remodelling and the SAGA HAT (histone acetyltransferase) complexes, and can bind to acetylated lysine residues in the N-terminal tails of the histones. Lysine acetylation is a histone modification that forms a stable epigenetic mark on chromatin for bromodomain-containing proteins to dock and in turn regulate gene expression. In order to better understand how bromodomains read the ‘histone code’ and interact with acetylated histones, we have tested the interactions of several bromodomains withi
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Liu, Yuxuan, Jole Fiorito, Yulissa Gonzalez, et al. "Development of First-in-Class Histone Acetyltransferase (HAT) Activators for Precision Targeting of Epigenetic Derangements in Lymphoma." Blood 132, Supplement 1 (2018): 37. http://dx.doi.org/10.1182/blood-2018-99-110447.

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Abstract Monoalleleic inactivating mutations in histone acetyltransferase (HAT) enzymes promote lymphomagenesis in germinal center derived B-cell lymphomas, follicular lymphoma (FL) and diffuse large B cell lymphoma (DLBCL), occurring in about 40% of patients. The intact wild-type allele offers an opportunity to leverage the normal enzyme to overcome the pathogenic impact of the mutated allele. We hypothesize that if inactivating mutations in HATs are critical to FL and DLBCL lymphomagenesis, then drugs capable of inducing enhanced function of the wild-type HAT allele product should be cytotox
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Liu, Yuxuan, Jole Fiorito, Yulissa Gonzalez, et al. "Strategy for Overcoming Crebbp and EP300 Mutations in Lymphoma: Development of First-in-Class HAT Activators." Blood 134, Supplement_1 (2019): 4068. http://dx.doi.org/10.1182/blood-2019-125983.

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Epigenetic dysregulation is a hallmark of germinal center derived B cell lymphomas. In particular, the monoallelic mutations in histone acetyltransferases (HATs), p300 and CBP are present in approximately 40% of DLBCL and FL patients. The haploinsufficiency of CBP leads to loss of MHC which contributes to both immune escape and lymphomagenesis. The intact wild-type allele offers an opportunity to leverage the normal enzyme to overcome the pathogenic impact of the mutated allele. We reported our lead compound YF2 out of a library (n=70) of HAT activators led to significant cytotoxic effect in l
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Imoberdorf, Rachel Maria, Irini Topalidou, and Michel Strubin. "A Role for Gcn5-Mediated Global Histone Acetylation in Transcriptional Regulation." Molecular and Cellular Biology 26, no. 5 (2006): 1610–16. http://dx.doi.org/10.1128/mcb.26.5.1610-1616.2006.

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ABSTRACT Transcriptional activators often require histone acetyltransferases (HATs) for full activity. The common explanation is that activators directly recruit HATs to gene promoters to locally hyperacetylate histones and thereby facilitate transcription complex formation. However, in addition to being targeted to specific loci, HATs such as Gcn5 also modify histones genome-wide. Here we provide evidence for a role of this global HAT activity in regulated transcription. We show that activation by direct recruitment of the transcriptional machinery neither recruits Gcn5 nor induces changes in
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Wang, L., C. Mizzen, C. Ying, et al. "Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation." Molecular and Cellular Biology 17, no. 1 (1997): 519–27. http://dx.doi.org/10.1128/mcb.17.1.519.

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Yeast and human ADA2 and GCN5 (y- and hADA2 and y- and hGCN5, respectively) have been shown to potentiate transcription in vivo and may function as adaptors to bridge physical interactions between DNA-bound activators and the basal transcriptional machinery. Recently it was shown that yGCN5 is a histone acetyltransferase (HAT), suggesting a link between enzymatic modification of nucleosomes and transcriptional activation. In this report, we demonstrate that hGCN5 is also an HAT and has the same substrate specificity as yGCN5. Since hGCN5 does not complement functional defects caused by deletio
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Panne, Daniel. "Chromatin recognition and regulation of the acetyltransferase CBP/p300." Acta Crystallographica Section A Foundations and Advances 70, a1 (2014): C1586. http://dx.doi.org/10.1107/s2053273314084137.

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Gene regulation in higher eukaryotes requires recruitment of the transcriptional co-activators CBP/p300 that associate with transcriptional regulators and integrate a large number of signal transduction pathways. Recruitment of CBP/p300 results in acetylation and remodeling of inhibitory chromatin. Recently we have determined the 2.8Å crystal structure of the catalytic core of p300 containing its Bromodomain, the CH2 region and HAT domain in complex with the bi-substrate inhibitor, Lys-CoA. Unexpectedly the structure reveals that the CH2 region contains a discontinuous PHD domain which is inte
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Dissertations / Theses on the topic "HAT Activators"

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Cassel, Raphaelle. "Impact de la réactivation de l'acétylation des histones sur les performances mnésiques dans un modèle transgénique murin de la maladie d'Alzheimer : vers une nouvelle stratégie thérapeutique ?" Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAJ040/document.

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La maladie d’Alzheimer (MA) est caractérisée par une perte progressive des capacités mnésiques et des fonctions cognitives accompagnée du développement de dégénérescences neurofibrillaires (DNFs) et de plaque séniles dans le parenchyme cérébral. La découverte de perturbations épigénétiques dans des cerveaux de patients Alzheimer ont mené la communauté scientifique à se tourner vers de nouvelles voies thérapeutiques. De telles altérations, notamment au niveau de l’acétylation des histones de la chromatine, pourraient rendre compte de dysfonctionnements dans l’expression des programmes génétique
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Ha, Yuan-Pei, and 哈元蓓. "Hepatocyte growth factor activator inhibitor type 2 (HAI-2) acts as a negative regulator for cancer stem cell-related factors in prostate cancer cells." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/50539832794058259142.

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碩士<br>國立臺灣大學<br>生物化學暨分子生物學研究所<br>100<br>Cancer stem cells (CSCs)/cancer initiating cells represent a minor population of tumor cells with the properties of self-renewal or cancer progenitor cells, contributing to tumor progression. To further delineate the molecular mechanisms of prostate cancer progression linked to the expression changes of stem cell-related genes, a prostate cancer progression model was established by orthotopic injection of prostate cancer CWR22Rv1 cells into nude mice. Fourteen weeks after the injection, the tumor cells metastazing into the lung were isolated as 14w CWR22
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Books on the topic "HAT Activators"

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Verheugt, Freek W. A. Fibrinolytic therapy. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0038.

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Fibrinolytic agents are able to reopen blood vessels that are occluded by a fresh thrombus. Urokinase, streptokinase, and streptokinase derivatives were the first effective agents. Recombinant plasminogen activators became available and they are specific for thrombus-bound fibrin. Significant bleeding is the major side effect of fibrinolysis, a major hurdle for its use. The current era of mechanical reperfusion has made fibrinolytic therapy a niche treatment for acute arterial thrombosis such as ST elevation myocardial infarction and stroke. Only for pulmonary embolism with haemodynamic conseq
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Chong, Ji Y., and Michael P. Lerario. Treatment of Acute Right-Sided Weakness. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190495541.003.0001.

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Intravenous tissue plasminogen activator (IV tPA) is the mainstay of stroke therapy and is US Food and Drug Administration-approved for the treatment of acute ischemic stroke. Its benefit on functional outcome has been established in multiple randomized trials when administered within 3 hours. Select patients may be treated off-label up to 4.5 hours from symptom onset. Eligibility criteria need to be reviewed carefully to optimize benefit and to minimize complications, namely reperfusion hemorrhage.
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Capodanno, Davide. Bivalirudin and argatroban. Edited by Raffaele DeCaterina. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0052.

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The central role of thrombin in the process of clot formation makes it an important therapeutic target. Heparin is a potent anticoagulant, but has a number of limitations, in that—for example—it does not bind clot-bound thrombin, activates platelets, and may determine heparin-induced thrombocytopenia (HIT). Bivalirudin and argatroban, which belong to the class of intravenous direct thrombin inhibitors, overcome many of the limitations of heparin. Bivalirudin is currently indicated for patients undergoing percutaneous coronary intervention, patients with non-ST-segment elevation acute coronary
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Hastie, Nick, and Eve Miller-Hodges. WT1 and its disorders. Edited by Neil Turner. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0329_update_001.

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Mutations in the Wilms tumour suppressor gene, WT1, are associated with Wilms tumour in childhood. However, in addition WT1 has a key role in renal development, emerging roles in podocyte function, and a potential role in tissue regeneration. An understanding of WT1 is of increasing importance to clinical practice. WT1 is a complex gene with multiple isoforms. It is crucial for normal embryonic development, especially kidney development, where it is necessary for mesenchymal-to-epithelial transition to form the nephron. WT1 mutations lead to abnormalities in renal and genitourinary development
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Vaghi, M. M., and T. W. Robbins. Task-Based Functional Neuroimaging Studies of Obsessive-Compulsive Disorder: A Hypothesis-Driven Review. Edited by Christopher Pittenger. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190228163.003.0022.

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The neurobiological basis of Obsessive Compulsive Disorder (OCD) has been probed using functional magnetic resonance in hundreds of studies over three decades. This complex literature can be syntheized using a theory-informed approach. At a theoretical level, separable, independent, constructs of relevance to OCD have been identified. At the experimental level, extensive translational evidence has provided an account that relates specific brain systems to these neuropsychological constructs. Parallels between neural substrates implicated in OCD and functional specialization of different brain
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Gallagher, Shaun. Action and the Problem of Free Will. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198794325.003.0007.

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This chapter examines the concept of free will as it is discussed in philosophy and neuroscience. It reviews reflective and perceptual theories of agency and argues against neuro-centric conclusions about the illusory nature of free will. Experiments conducted by Benjamin Libet suggest that neural activations prior to conscious awareness predict specific actions. This has been taken as evidence that challenges the traditional notion of free will. Libet’s experiments, arguably, are about motor control processes on an elementary timescale and say nothing about freely willed intentional actions e
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Brown, David P. Lots Will Vary in the Available City. Edited by Benjamin Piekut and George E. Lewis. Oxford University Press, 2015. http://dx.doi.org/10.1093/oxfordhb/9780199892921.013.17.

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Michel de Certeau has described our movement about the city as improvisational—as an interaction with a spatial order that not only activates that order’s ensemble of possibilities but transforms and introduces new possibilities for elements comprising that order. However, architecture’s relation to improvisation is not limited to this provision of a fixed context, an offering of material that is the basis of our daily play. A number of writings about architecture and urbanism by Jane Jacobs, Roger Sherman, and Stan Allen identify improvisation in aspects of the design of the city itself. Alon
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Williams, David-Antoine. The Life of Words. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780198812470.001.0001.

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For centuries, investigations into the origins of words were entwined with investigations into the origins of humanity and the cosmos. With the development of modern etymological practice in the nineteenth century, however, many cherished etymologies were shown to be impossible, and the very idea of original ‘true meaning’ asserted in the etymology of ‘etymology’ declared a fallacy. Structural linguistics later held that the relationship between sound and meaning in language was ‘arbitrary’, or ‘unmotivated’, a truth that has survived with small modification until today. On the other hand, the
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Zolf, Rachel. No One's Witness. Duke University Press, 2021. http://dx.doi.org/10.1215/9781478021551.

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In No One's Witness Rachel Zolf activates the last three lines of a poem by Jewish Nazi holocaust survivor Paul Celan—“No one / bears witness for the / witness”—to theorize the poetics and im/possibility of witnessing. Drawing on black studies, continental philosophy, queer theory, experimental poetics, and work by several writers and artists, Zolf asks what it means to witness from the excessive, incalculable position of No One. In a fragmentary and recursive style that enacts the monstrous speech it pursues, No One's Witness demonstrates the necessity of confronting the Nazi holocaust in rel
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Wiklund, Olov, and Jan Borén. Pathogenesis of atherosclerosis: lipid metabolism. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198755777.003.0011.

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Lipids are carried in plasma as microparticles, lipoproteins, composed of a core of hydrophobic lipids and a surface of amphipathic lipids. In addition, the particles carry proteins (i.e. apolipoproteins). The proteins have key functions in the metabolism as receptor ligands, enzymes or activators. Lipoproteins are classified based on density into: chylomicrons, VLDL, IDL, LDL, and HDL. Retention of apoB-containing lipoproteins (LDL, IDL, and VLDL) in the arterial intima is the initiating event in the development of atherosclerosis. Retention is mediated by binding of apoB to structural proteo
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Book chapters on the topic "HAT Activators"

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Kawase, Tatsuya, Yu Chen, and Rieko Ohki. "IER5 Is a p53-Regulated Activator of HSF1 That Contributes to Promotion of Cancer." In Heat Shock Proteins. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-03952-3_13.

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Thanh, H. T., M. J. Tapas, J. Chandler, and V. Sirivivatnanon. "Creep of Slag Blended Cement Concrete with and Without Activator." In Lecture Notes in Civil Engineering. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-3330-3_19.

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AbstractPartly replacing Portland cement (PC) with lower carbon footprint cementitious materials such as ground granulated blast furnace slag (slag) is considered as a practical method for reducing CO2 emissions in the cement concrete industry. To mitigate the slow reactivity of slag in a cementitious system and enhance early-age strength, the addition of a chemical activator is a solution. However, the effect of the activator on creep behaviour of slag-blended cement concretes remains unclear. This work presents the effect of sodium sulfate (Na2SO4) activator on the compressive creep of PC co
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Gonzalez-Gronow, Mario, and Salvatore V. Pizzo. "Interaction Between Heat Shock Proteins and Components of the Plasminogen Activator System in the Central Nervous System." In Heat Shock Proteins in Neuroscience. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-24285-5_4.

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Kataoka, Hiroaki, and Takeshi Shimomura. "HGF Activator (HGFA) and its Inhibitors HAI-1 and HAI-2: Key Players in Tissue Repair and Cancer." In Extracellular Targeting of Cell Signaling in Cancer. John Wiley & Sons, Ltd, 2018. http://dx.doi.org/10.1002/9781119300229.ch3.

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Ke, Yuanyuan, Jing Li, and Yifu Wang. "Chemotaxis–Haptotaxis System." In Financial Mathematics and Fintech. Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-3763-7_3.

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AbstractCancer invasion and metastasis are influenced by a plethora of biochemical processes and involve many biochemical mechanisms, among which chemotaxis and haptotaxis are two of the main mechanisms directing the migration of cancer cells Chaplain and Lolas (2005). Evidence has been found that cancer cells release complex enzymes such as the urokinase-type plasminogen activator (uPA), which degrade the surrounding extracellular matrix (ECM), and thereby allow the migration of cells following the concentration gradient of such diffusive enzymes. This process is referred to as chemotaxis Cha
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Bishr, Mai K., and Ben O’Leary. "Mechanism of Action and Potential Use of SMAC Mimetics in Head and Neck Squamous Cell Carcinoma (HNSCC)." In Critical Issues in Head and Neck Oncology. Springer Nature Switzerland, 2025. https://doi.org/10.1007/978-3-031-84539-0_6.

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Abstract Patients with head and neck squamous cell carcinoma (HNSCC) often present with locally advanced disease and despite aggressive treatment, relapse remains a significant challenge. Evasion of apoptosis, a mode of regulated cell death, has been implicated in treatment resistance and poor prognosis, partly via overexpression of inhibitor of apoptosis proteins (IAPs). Thus, therapeutic strategies targeting the anti-apoptotic machinery are being explored; one such strategy is the design of compounds that mimic the naturally occurring endogenous second mitochondria-derived activator of caspa
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Evolvi, Giulia. "“Europe is Christian, or It Is Not Europe”: Post-Truth Politics and Religion in Matteo Salvini’s Tweets." In Europe in the Age of Post-Truth Politics. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-13694-8_7.

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AbstractPost-truth narratives are often connected to the online spreading of far-right ideologies and hate speech. Disinformation has also been studied in relation to religion, as it tends to target religious people and involve narratives about Christianity and Islam. In this chapter, I explore the use of post-truth online narratives about religion by focusing on the case of Italian populist political leader Matteo Salvini, who is renowned for his anti-Islam positions, for his Catholic faith, and for his intense use of social media. Through an analysis of tweets sent by Salvini between Septemb
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Rose, D. W., T. M. Mullek, M. G. Rosenfeld., and C. k. Glass. "Functional characterization of co-activators using mammalian cell microinjection." In Nuclear Receptors. Oxford University PressOxford, 1999. http://dx.doi.org/10.1093/oso/9780199637430.003.0005.

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Abstract The past few year; have led to an appreciation that the transcriptional activity of the nuclear receptor family is regulated by binding of the receptor. in a ligand-dependent manner. to a multicomponent complex of co-activator proteins. many of which possess histone acetyltransferase activity. The activity of these co-activators is; also further regulated by a variety of signal transduction pathways. Many of these co-activator molecules have now been isolated, often on the basis of their interaction with the nuclear receptors. The functional characterization of these protein complexes
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Nabel, Gary J. "The role of cellular transcription factors in the regulation of human immunodeficiency virus gene expression." In Human Retroviruses. Oxford University PressOxford, 1993. http://dx.doi.org/10.1093/oso/9780199633821.003.0003.

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Abstract The human immunodeficiency virus (HIV) is dependent on its host cell for the synthesis and processing of viral RNA. Steady-state levels of viral RNA can be regulated by several mechanisms, including the rate of transcriptional initiation, elongation, processing, export, and packaging. Diverse regulatory mechanisms have, therefore, evolved to control viral RNA during HIV replication. These events play a critical role in the regulation of viral replication. Relative to the human genome, the genomic complexity of HIV is relatively small, &amp;lt;0.001% in size. To regulate viral gene exp
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Teng, Rebecca S. Y. "The Future of Fibrinolysis Agents." In Fibrinolysis - Past, Present and Future [Working Title]. IntechOpen, 2024. http://dx.doi.org/10.5772/intechopen.115012.

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Since the 1990s, the second-generation tissue plasminogen activator alteplase has been accepted as the gold standard in the thrombolysis of acute ischemic stroke, acute myocardial infarction, and pulmonary embolism. Alteplase, however, is not without its limitations, including a short half-life precluding single-bolus administration and elevated risk of both local and systemic bleeding. Efforts have been made to create “third-generation agents” with longer half-lives, improved fibrin specificity, and safety profiles compared to alteplase. The majority of the current Federal Drug Authority (FDA
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Conference papers on the topic "HAT Activators"

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Karakira, Susan, Betty Leung, Karyna Bañuelos, et al. "The Effect of the Chromium Content on the Pack Aluminizing of Binary Nickel-Chromium Alloys." In CORROSION 2016. NACE International, 2016. https://doi.org/10.5006/c2016-07838.

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Abstract Halide Activated Pack Cementation (HAPC) is a cost-effective and efficient surface modification process that increases the durability of a metallic alloy. This technique has been utilized to protect alloys operating in a wide variety of high temperature environments. The method can create a hard, corrosion-resistant, diffusional coating through chemical reactions that occur in a “pack” consisting of an inert filler (typically aluminum oxide), a master alloy, and a halide activator. A study was conducted in which pure nickel, Ni-5 wt% Cr and Ni-10 wt% Cr were aluminized at 750, 850 and
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Gargan, P. E., and V. A. Ploplis. "IDENTIFICATION AND PURIFICATION OF AN INHIBITOR TO PLASMINOGEN ACTIVATORS FROM PROSTATE ADENOCARCINOMA CELLS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643192.

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The rat prostate adencarcinoma cell line (PA-III), derived from qerm-free Lobund Wistar rats has served as a unique model for prostatic cancer. The supernatant from confluent cultures of the cell line was shown by zymographic analysis to contain three molecular forms of plasminogen activator. One of the activators was characterized in a previous study and has been classified as a tissue type plasminogen activator(Mr=30,000). In the same study the activator with a Mr=45,000 was shown to be of the urokinase class. The high molecular weight(Mr=120, 000) activator, which has not been described pre
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LÁTAL, Oldřich, Petr ŠAŘEC, Petr NOVÁK, and Jitka KUMHÁLOVÁ. "INFLUENCE OF THE ACTIVATORS TO THE DIFFERENT VEGETATION INDEXES IN CENTRAL BOHEMIA REGION." In RURAL DEVELOPMENT. Aleksandras Stulginskis University, 2018. http://dx.doi.org/10.15544/rd.2017.200.

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High proportion of arable land is typically for agriculture in Czech Republic. Nowadays there is a problem with decrease of livestock production and increase of biofuel production. This problems causes decrease in the level of soil carbon in the soil. Decrease in levels of organic carbon also leads to easier soil degradation by other negative factors (soil erosion, compaction). Organic matter application into soils is the only corrective action. Decomposition of applied organic matter is a problem in the decarburized soils. Organic matter can be supplemented by biological transformation’s acti
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Alyami, Noktan Mohammed, Vikrant Wagle, Abdullah Saleh Alyami, and Rajendra Kalgaonkar. "Anionic Nanoparticle Based Formulation to Control and Cure Moderate to Severe Losses." In ADIPEC. SPE, 2022. http://dx.doi.org/10.2118/211493-ms.

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Abstract Moderate to severe losses can be treated using the loss circulation composition involving nanomaterial-based dispersion and a chemical activator. The nanomaterial employed is an environmentally friendly type of nanosilica. The composition facilitates delayed gelling of nanomaterial-based dispersion. One key benefit of this technology is that it can place the composition into the target loss circulation zone before the nanomaterial-based dispersion gels up. This ensures that the treatment fluid does not set prematurely before reaching the target zone. It is possible to effectively use
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Leiner, Wolfgang, and Karl-Heinrich Losing. "HEAT TRANSFER IMPROVEMENT IN NUCLEATE BOILING THROUGH APPLICATION OF POORLY WETTABLE NUCLEATION ACTIVATORS." In International Heat Transfer Conference 8. Begellhouse, 1986. http://dx.doi.org/10.1615/ihtc8.1520.

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Kiso, U., H. Kaudewitz, A. Henschen, B. Åstedt, E. K. O. Kruithof, and F. Bachmann. "DETERMINATION OF INTERMEDIATES, PRODUCTS AND CLEAVAGE SITE IN THE REACTION BETWEEN PLASMINOGEN ACTIVATOR INHIBITOR 2 (PAI 2) AND UROKINASES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642809.

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Several specific inhibitors for both urokinase-type and tissue-type plasminogen activators have in recent years been isolated from various organs and cell lines. The inhibitors isolated from human placenta and from the human histiocytic lymphoma cell line U-937 have been shown to be immunologically related.They are denoted as plasminogen activator inhibitor type 2 (PAI 2). It has earlier been demonstrated by gel electrophoresis that during the inhibition reaction at first complexes are formed between activator and inhibitor and then the inhibitor is cleaved and the complex can be dissociated.I
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Loskutoff, D. J., J. Mimuro, and C. Hekman. "PLASMINOGEN ACTIVATOR INHIBITOR." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644763.

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Plasminogen activation provides an important source of localized proteolytic activity not only during fibrinolysis, but also during ovulation, cell migration, epithelial cell differentiation, tumor invasion and a variety of other physiological processes. Precise regulation of plasminogen activator (PA) activity thus constitutes a critical feature of many biological processes. This control is achieved in large part through the action of specific PA inhibitors (PAIs). Although 4 distinct PAIs have been detected,1the endothelial cellTderived inhibitor (PAI-1) is the only one that efficiently inhi
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Joseph, S. K., S. Krlshnamurthi, Y. Patel, and V. V. Kakkar. "1,2-DIOCTANOYLGLYCERIOL (diC8) BUT NOT 1-OLEOYL 2-ACETYLGLYCEROL (OAG) INHIBITS AGONIST-INDUCED PLATELET RESPONSES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644506.

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Inhibition of agonist-induced platelet responses by phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PrkC), has been reported. We have examined the effects of the diacylglycerol (DG) analogues OAG and diCg, both PrkC activators, as well as PMA on intracellular Ca2+ ([Ca2+]i) mobilisation and 5-hydroxytryptamine (5HT) release induced by thrombin (T), collagen (Coll.) and the thromboxane (Tx) mimetic U46619. All studies were performed using washed human platelets pre-labelled with either quin-2 or [14C]-5HT and maximal concentrations of agonists. Neither diCg or PMA eleva
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Krishnamurti, C., B. M. Alving, and D. G. Wright. "INDUCTION OF PLASMINOGEN ACTIVATOR AND PLASMINOGEN ACTIVATOR INHIBITOR ACTIVITY DURING DIFFERENTIATION OF HL-60 CELLS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644390.

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While increased production of plasminogen activator(PA) has been associated with malignant growth and differentiation, the effect of cell maturation on plasminogen activator inhibitor (PAI) production has not yet been defined. We therefore determined the effect of phorbol myristate acetate(PMA), an agent that induces monocytoid cellular maturation, on the secretion of both PA and PAI in HL-60 cells, a promyelocytic leukemia cell line. Cells were seeded at 5x105/ml and grown in a 5% CO2 incubator at 37°C in a serum-free medium in the absence or presence of 1.6 nM PMA. Experiments were performed
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Yakovlev, Andrey, Valerie Lafitte, Saurabh Kapoor, et al. "An Innovative and Sustainable Portland Cement Alternative for Oil and Gas Wells." In SPE International Conference on Oilfield Chemistry. SPE, 2023. http://dx.doi.org/10.2118/213805-ms.

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Abstract The manufacturing process of oilfield cement is one of the largest contributors to carbon emissions. Thus, finding sustainable alternative materials has become the main focus globally. Geopolymers are low carbon cement alternatives that have been used in the construction industry for many years, yet their applicability for oil and gas wells remains unproven. For geopolymers to be successfully implemented in the oilfield industry, a customization of the formulation is critical to eliminate logistical constraints and ensure compatibility with oilfield pumping equipment. Geopolymers are
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Reports on the topic "HAT Activators"

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Sessa, Guido, and Gregory Martin. Role of GRAS Transcription Factors in Tomato Disease Resistance and Basal Defense. United States Department of Agriculture, 2005. http://dx.doi.org/10.32747/2005.7696520.bard.

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The research problem: Bacterial spot and bacterial speck diseases of tomato are causedby strains of Xanthomonas campestris pv. vesicatoria (Xcv) and Pseudomonas syringae pv.tomato (Pst), respectively. These bacteria colonize aerial parts of the plant and causesignificant losses in tomato production worldwide. Protection against Xcv and Pst bycultural practices or chemical control has been unsuccessful and there are only limitedsources of genetic resistance to these pathogens. In previous research supported in part byBARD IS-3237-01, we extensively characterized changes in tomato gene expressio
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Alfano, James, Isaac Barash, Thomas Clemente, Paul E. Staswick, Guido Sessa, and Shulamit Manulis. Elucidating the Functions of Type III Effectors from Necrogenic and Tumorigenic Bacterial Pathogens. United States Department of Agriculture, 2010. http://dx.doi.org/10.32747/2010.7592638.bard.

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Many phytopathogenic bacteria use a type III protein secretion system (T3SS) to inject type III effectors into plant cells. In the experiments supported by this one-year feasibility study we investigated type III effector function in plants by using two contrasting bacterial pathogens: Pseudomonas syringae pv. tomato, a necrotrophic pathogen and Pantoea agglomerans, a tumorigenic pathogen. The objectives are listed below along with our major conclusions, achievements, and implications for science and agriculture. Objective 1: Compare Pseudomonas syringae and Pantoea agglomerans type III effect
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Desai, Jairaj, Rahul Suryakant Sakhare Sakhare, Justin Mahlberg, Jijo K. Mathew, Howell Li, and Darcy M. Bullock. Implementation of Enhanced Probe Data (CANBUS) for Tactical Workzone and Winter Operations Management. Purdue University, 2023. http://dx.doi.org/10.5703/1288284317643.

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For over a decade, segment-based probe data has been extensively used by transportation stakeholders for monitoring mobility on Indiana roadways. However, enhanced probe data from connected vehicles includes a richer dataset that can provide more detailed real-time and after-action reviews. This enhanced data includes detailed vehicle trajectories, at 3s resolution, and “event data.” This event data is near real-time and includes hard-braking events, hard-acceleration events, weather-related data, including wiper activations and some seat belt usage data. This project developed a set of method
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Petrenko, Larisa M., Iryna P. Varava, and Andrey V. Pikilnyak. Motivation readiness of future software engineer's professional self-improvement and prospects of its formation in college cloud environment. [б. в.], 2020. http://dx.doi.org/10.31812/123456789/3893.

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Innovative technologies have an impact on the countries socio- economic development, the structure of labor market and educational services transformation. Rapid IT industry development constantly requires qualified programmers capable of professional self-improvement throughout life, the driving force of which is the individual motivation which activates the individual self-development process, optimizes thinking and develops special professional qualities, moral and ethical values. The main article purpose is to analyze the state of the form of motivational readiness for future programmer’s
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Makhachashvili, Rusudan K., Svetlana I. Kovpik, Anna O. Bakhtina, and Ekaterina O. Shmeltser. Technology of presentation of literature on the Emoji Maker platform: pedagogical function of graphic mimesis. [б. в.], 2020. http://dx.doi.org/10.31812/123456789/3864.

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The article deals with the technology of visualizing fictional text (poetry) with the help of emoji symbols in the Emoji Maker platform that not only activates students’ thinking, but also develops creative attention, makes it possible to reproduce the meaning of poetry in a succinct way. The application of this technology has yielded the significance of introducing a computer being emoji in the study and mastering of literature is absolutely logical: an emoji, phenomenologically, logically and eidologically installed in the digital continuum, is separated from the natural language provided by
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Yibchok-anun, Sirinthorn, Wijit Banlunara, and Sirichai Adisakwattana. Antidiabetic effects, mechanisms of of p-methoxy-trans-cinnamic acid. Faculty of Veterinary Science, Chulalongkorn University, 2008. https://doi.org/10.58837/chula.res.2008.81.

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p-Methoxycinnamic acid (p-MCA) is a cinnamic acid derivative that shows various pharmacologic actions such as neuroprotective and hepatoprotective activities. To examine the insulinotropic activity of p-MCA, the perfused rat pancreas and a pancreatic β-cell line, INS-1 were used in the studies. P-MCA increased insulin secretion from the perfused rat pancreas and INS-1 cells in a concentration-dependent manner. In addition, p-MCA increased intracellular Ca²⁺ concentration ([Ca²⁺]i) in INS-1 cells. The p-MCA-induced insulin secretion and rise in [Ca²⁺]i were markedly inhibited in the absence of
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Splitter, Gary, Zeev Trainin, and Yacov Brenner. Lymphocyte Response to Genetically Engineered Bovine Leukemia Virus Proteins in Persistently Lymphocytic Cattle from Israel and the U.S. United States Department of Agriculture, 1995. http://dx.doi.org/10.32747/1995.7570556.bard.

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The goal of this proposal was to identify proteins of BLV recognized by lymphocyte subpopulations and determine the contribution of these proteins to viral pathogenesis. Our hypothesis was that BLV pathogenesis is governed by the T-cell response and that the immune system likely plays an important role in controlling the utcome of infection. Our studies presented in ths final report demonstrate that T cell competency declines with advancing stages of infection. Dramatic differences were observed in lymphocyte proliferation to recombinant proteins encoded by BLV gag (p12, p15, and p24) and env
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Applebaum, Shalom W., Lawrence I. Gilbert, and Daniel Segal. Biochemical and Molecular Analysis of Juvenile Hormone Synthesis and its Regulation in the Mediterranean Fruit Fly (Ceratitis capitata). United States Department of Agriculture, 1995. http://dx.doi.org/10.32747/1995.7570564.bard.

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Original Objectives and revisions: (1) "To determine the biosynthetic pathway of JHB3 in the adult C. capitata CA in order to establish parameters for the future choice and synthesis of suitable inhibitors". Modified: to determine the pattern of FR-7 biosynthesis during normal reproductive maturation, and identify enzymes potentially involved in its synthesis. (2) "To correlate allatal epoxidase activity to the biosynthesis of JHB3 at different stages of reproductive maturation/vitellogenesis and evaluate the hypothesis that a specific JH-epoxidase may be rate limiting". Modified: to study the
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Olszewski, Neil, and David Weiss. Role of Serine/Threonine O-GlcNAc Modifications in Signaling Networks. United States Department of Agriculture, 2010. http://dx.doi.org/10.32747/2010.7696544.bard.

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Significant evidence suggests that serine/threonine-O-linked N-acetyl glucosamine0-(GlcNAc) modifications play a central role in the regulation of plant signaling networks. Forexample, mutations in SPINDLY,) SPY (an O-GlcNAc transferase,) OGT (promote gibberellin GA) (signal transduction and inhibit cytokinin responses. In addition, mutating both Arabidopsis OGTsSEC (and SPY) causes embryo lethality. The long-term goal of this research is to elucidate the mechanism by which Arabidopsis OGTs regulate signaling networks. This project investigated the mechanisms of O-GlcNAc regulation of cytokini
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Fromm, Hillel, Paul Michael Hasegawa, and Aaron Fait. Calcium-regulated Transcription Factors Mediating Carbon Metabolism in Response to Drought. United States Department of Agriculture, 2013. http://dx.doi.org/10.32747/2013.7699847.bard.

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Original objectives: The long-term goal of the proposed research is to elucidate the transcription factors, genes and metabolic networks involved in carbon metabolism and partitioning in response to water deficit. The proposed research focuses on the GTLcalcium/calmodulinbindingTFs and the gene and metabolic networks modulated by these TFs in Arabidopsis thaliana. The specific objectives are as follows. Objective-1 (USA): Physiological analyses of GTL1 loss- and gain-of-function plants under water sufficient and drought stress conditions Objective 2 (USA / Israel-TAU): Characterizion of GTL ta
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