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Journal articles on the topic 'HBGS'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Kostamo, Zachary, Jawa Darazim, Britney Hernandez, et al. "Evaluation of the Impact of a Naturally Occurring Beta Hemoglobin Variant, Hb G-Makassar, on Mature Red Blood Cell Function and Pathology in a Sickle Cell Disease Mouse Model." Blood 142, Supplement 1 (2023): 2251. http://dx.doi.org/10.1182/blood-2023-186237.

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Background: Gene based therapy may provide a cure for individuals with sickle cell disease (SCD); base editing is a novel strategy with the ability to directly edit the mutation responsible for disease. The sickle hemoglobin (HbS) point mutation cannot be converted to wild-type HBB by an adenine base editor, however it can be converted to a naturally occurring hemoglobin variant, HbG-Makassar (HbG). HbG is a non-pathogenic, non-sickling hemoglobin variant. In vitro crystal structure analysis of HbG shows that it is highly similar to that of wildtype hemoglobin (HbA). However, few HbGG individu

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Lin, Zhanxiang, Xiaoyang Fei, Lichao Huang, Yuchun Shao, and Zicai Liu. "Evaluation of nerve function after Bell’s palsy based on different facial nerve assessment scales HBGS/SFGS/MPS: A comparative study." PLOS One 20, no. 6 (2025): e0326789. https://doi.org/10.1371/journal.pone.0326789.

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Background Studies have shown that approximately 30% of patients with Bell’s palsy may experience permanent disfigurement due to muscle weakness affecting facial expressions. The prognosis for Bell’s palsy is often correlated with the degree of impairment in facial nerve function observed in the early stages of the condition. Selecting appropriate assessment tools is essential for the effective treatment and prognosis of patients with Bell’s palsy. Objective Examine and compare three scales used to measure Bell’s palsy: the House-Brackmann Grading Scale (HBGS), the Sunnybrook Facial Grading Sy

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3

Nodari, Rubens Onofre, and Sônia Corina Hess. "Campeão de vendas, cientificamente o Glifosato é um agrotóxico perigoso." Extensio: Revista Eletrônica de Extensão 17, no. 35 (2020): 2–18. http://dx.doi.org/10.5007/1807-0221.2020v17n35p2.

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Os herbicidas à base de glifosato (HBGs) contém, além do principio ativo (glifosato), outras substâncias como surfactantes e adjuvantes. Este artigo teve como objetivo a apresentação de uma revisão da literatura acerca dos riscos à saúde humana, de animais e aos ecossistemas, associados à exposição aos HBGs. Espera-se que o conteúdo possa ser útil ao aperfeiçoamento das práticas e políticas publicas relacionadas ao uso dos referidos agrotóxicos. Para a realização da presente pesquisa, foram consultadas bases de dados disponíveis em portais de periódicos institucionais. Descreve-se que, embora

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Rickenmann, Jürg, Claude Jaquenod, D. Cerenko, and Ugo Fisch. "Comparative Value of Facial Nerve Grading Systems." Otolaryngology–Head and Neck Surgery 117, no. 4 (1997): 322–25. http://dx.doi.org/10.1016/s0194-5998(97)70120-7.

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The Fisch Detailed Evaluation of Facial Symmetry (DEFS) and House-Brackmann grading system (HBGS) were compared by statistical examination for their reliability and interob-server variability. Furthermore, the correlation and agreement with a standard global evaluation were compared. Therefore 47 patients with facial palsy of different cause have been evaluated with the two systems, and the global overall evaluation was done by five otolaryngologists familiar with facial palsy. The DEFS showed a high reliability of 0.93 compared with a reliability of 0.77 with the HBGS (international standard

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5

Liu, Zengqi, Guangqi Zhang, Fangfang Lu, et al. "The Experimental and Modeling Study on the Thermodynamic Equilibrium Hydrate Formation Pressure of Helium-Rich Natural Gas in the Presence of Tetrahydrofuran." Molecules 29, no. 20 (2024): 4827. http://dx.doi.org/10.3390/molecules29204827.

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Hydrate-based gas separation (HBGS) has good potential in the separation of helium from helium-rich natural gas. HBGS should be carried out under a pressure higher than the thermodynamic equilibrium hydrate formation pressure (Peq) to ensure the formation of hydrate so that the accurate prediction of Peq is the basis of the determination of HBGS pressure. In this work, the Peq of the helium-rich natural gases with different helium contents (1 mol%, 10 mol%, and 50 mol%) in gas and different tetrahydrofuran (THF) contents (5 wt%, 10 wt%, and 19 wt%) in liquid at different temperatures were expe

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6

Chaiyalap, Somchet, Ritthikrai Chai-ngam, Juthaporn Saengprajak, Jenjira Piamdee, Apipong Putkham, and Arnusorn Saengprajak. "Effect of the non-uniform combustion core shape on the biochar production characteristics of the household biomass gasifier stove." International Journal of Renewable Energy Development 12, no. 6 (2023): 1018–29. http://dx.doi.org/10.14710/ijred.2023.56575.

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The global demand for biochar in agricultural and carbon sequestration applications is increasing; nevertheless, biochar production using the 50-liter household biomass gasifier stove (50L-HBGS) in Thailand found major issues that need to be improved. The objective of this study was to study the effects of the airflow in the non-uniform combustion core shape (NCCS) on the biochar production characteristic of the 50L-HBGS. The new design of the NCCS was constructed and studied to replace the existing combustion core shape (ECCS) at Mahasarakham University. The height, air inlet, and air outlet

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7

Liu, Zengqi, Rui Wang, Haixin Chen, et al. "The Experimental and Modeling Study on the Effect of Ethane in Helium-Rich Natural Gas on the Thermodynamic Equilibrium of Hydrate Formation in the Presence of Tetrahydrofuran." Molecules 30, no. 10 (2025): 2109. https://doi.org/10.3390/molecules30102109.

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Hydrate-based gas separation (HBGS) is a new method for extracting helium from helium-rich natural gas (HNG). The ethane in HNG affects the thermodynamic equilibrium hydrate formation pressure (Peq), and Peq is crucial to the application of HBGS for extracting helium. In this work, the Peq of the HNGs with different ethane contents (0.5 mol%, 1.0 mol%, and 10 mol%) and the solutions with different tetrahydrofuran (THF) contents (5 wt%, 10 wt%, and 19 mol%) at different temperatures were experimentally investigated through the isothermal pressure search method. Ethane and THF have a competitive

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8

KOÇ UÇAR, Habibe, and Esra SARIGEÇİLİ. "Çocuklarda idiyopatik periferik fasiyal sinir paralizisinde steroid tedavisinin etkinliği ve prognostik faktörlerin belirlenmesi." Cukurova Medical Journal 47, no. 2 (2022): 660–71. http://dx.doi.org/10.17826/cumj.1053502.

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Purpose: The aim of the study is intended to investigate the etiology and clinical features of children with idiopathic peripheral facial palsy (IPFP) and to identify probable prognostic factors. It is also intended to investigate corticosteroid therapy and compare its efficacy. Materials and Methods: A total of 80 patients with newly diagnosed IPFP were included in the study. Demographic, clinical features and laboratory findings including age, gender, House Brackmann Facial Nerve Grading System (HBGS) grade at admission and follow-up, and the dosage and onset of steroid treatment were

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9

Kwon, Min-jin, Tae-ju Kim, Na-young Kim, et al. "A Case Report on Peripheral Facial Nerve Palsy and Sleep Disorders After Microvascular Decompression." Journal of Internal Korean Medicine 44, no. 5 (2023): 929–40. http://dx.doi.org/10.22246/jikm.2023.44.5.929.

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Objectives: This study reports on the efficacy of Korean medicine treatments for peripheral facial nerve palsy and sleep disorders that occur after microvascular decompression.Methods: A 57-year-old female patient with right facial palsy was treated with herbal medicines and acupuncture for 36 days. The treatment effect was evaluated using the House Brackmann Grading System (HBGS), Yanagihara’s Unweighed Grading System (Yanagihara’s score), and the Korean Modified Leeds Sleep Evaluation Questionnaire (KMLSEQ).Results: Following treatment, the patient showed a decrease in HBGS and an improvemen

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10

Nambiar, Abhishek, Ponnivalavan Babu, and Praveen Linga. "CO2 capture using the clathrate hydrate process employing cellulose foam as a porous media." Canadian Journal of Chemistry 93, no. 8 (2015): 808–14. http://dx.doi.org/10.1139/cjc-2014-0547.

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A new biodegradable porous medium has been employed in this work for the hydrate-based gas separation (HBGS) process to capture carbon dioxide in a fixed bed column from a precombustion stream. Propane (2.5 mol%) was added as a promoter to reduce the operating pressure of the HBGS process. Experiments were conducted at 6 MPa and 274.2 K at different water saturation levels (50% and 100%) in a cellulose foam bed. It was found that a normalized rate of hydrate formation was more than double for 50% as compared to 100% water-saturated level. In addition, kinetic modelling of hydrate formation in

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11

Kim, Gyu Hui, Jung Hyeon Park, Tae Kyung Kim, et al. "Correlation Between Accompanying Symptoms of Facial Nerve Palsy, Clinical Assessment Scales and Surface Electromyography." Journal of Acupuncture Research 39, no. 4 (2022): 297–303. http://dx.doi.org/10.13045/jar.2022.00220.

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Background: This retrospective study aimed to determine whether there were correlations between the number and type of accompanying symptoms of peripheral facial nerve palsy, and surface electromyography (SEMG) and clinical assessment scales to help diagnosis.Methods: There were 30, cases of peripheral facial nerve palsy at Visit 1 to the Korean Medicine Hospital, Dong-eui University, 22 cases at Visit 2 and 10 cases at Visit 3. The study period was from July 19, 2021 to November 31, 2021. Symptoms were evaluated three times (with two-week intervals which began 7 days from onset) using SEMG, c

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12

Steinhardt, M., and H. H. Thielscher. "Wachstumsleistung und Anpassung von Saugkälbern aus der Mutterkuhhaltung mit einer unterschiedlichen Hämoglobinkonzentration des Blutes." Archives Animal Breeding 47, no. 5 (2004): 443–53. http://dx.doi.org/10.5194/aab-47-443-2004.

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Abstract. Title of the paper: Growth performance and adaptation of suckler calves with a different hemoglobin content of blood from a cow-calf operation To characterize physiological variables in suckler calves of different developmental quality and fitness (hemoglobin content of blood low HbG1, moderate HbG2 and high HbG3) at early gowth with uniform husbandry system on suckler calves (36 German Red Pied, 5 German Black Pied, 17 male and 24 female) measurements of body weight and blood composition were done repeatedly at 9–14, 18–25, 28–35, 40–52 and 59–77 days of age. Mean birth weight was n

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13

Zhong, Weizheng, Haibo Yu, Xiaodan Rao, et al. "Efficacy of Manipulative Acupuncture Therapy Monitored by LSCI Technology in Patients with Severe Bell’s Palsy: A Randomized Controlled Trial." Evidence-Based Complementary and Alternative Medicine 2020 (December 16, 2020): 1–7. http://dx.doi.org/10.1155/2020/6531743.

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To determine if the effect of manipulative acupuncture monitored by laser speckle contrast imaging (LSCI) can improve facial blood perfusion in patients with severe Bell’s palsy. This randomized, single-blind, controlled trial included 120 newly diagnosed patients (within 14 days) with severe Bell’s palsy (House–Brackmann grading system (HBGS) ≥ grade IV). The patients were randomized (1 : 1) to receive either acupoints acupuncture combined with manipulations of twirling, lifting, and thrusting treatments (manipulative acupuncture) or acupoints acupuncture therapy alone (simple acupuncture). T

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14

Opyrchał, Jakub, Daniel Bula, Dominik Krakowczyk, Adam Maciejewski, Krzysztof Dowgierd, and Łukasz Krakowczyk. "Reanimacja nerwu twarzowego przy użyciu wolnego neurowaskularnego płata z mięśnia smukłego uda u pacjentów pediatrycznych." Chirurgia Plastyczna i Oparzenia / Plastic Surgery & Burns 11, no. 2 (2023): 25–31. http://dx.doi.org/10.15374/chpio2023006.

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Porażenie nerwu twarzowego to schorzenie niosące ze sobą istotne konsekwencję, szczególnie gdy pojawia się we wczesnym okresie życia. Stanowi poważny problem kliniczny ze względu na początkowo niepewną etiologię, ograniczone możliwości leczenia oraz jego wyniki, a także na fakt, iż ma znaczne implikacje zarówno funkcjonalne, jak i estetyczne. U dzieci z trwałym wrodzonym lub nabytym porażeniem nerwu twarzowego na skutek urazów bądź wynikającym z leczenia zabiegowego choroby nowotworowej strategia terapeutyczna obejmuje techniki chirurgiczne powiązane z intensywną rehabilitacją. U dzieci z prze

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15

Steinhardt, M., and H. H. Thielscher. "Effekte einer einmaligen oralen Eisenapplikation nach der Geburt auf die Gewichtsentwicklung sowie auf hämatologische Variablen, Hämoglobinderivate und Blutgasgehalte der Milchrindkälber während der Aufzucht in Gruppenhaltung mit Tränkeautomatenfütterung." Archives Animal Breeding 46, no. 4 (2003): 321–30. http://dx.doi.org/10.5194/aab-46-321-2003.

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Abstract. Title of the paper: Effects of a single oral iron application on growth and on hematological variables, hemoglobin derivatives and blood gas content in group housed feeder-fed dairy calves To characterize physiological variables in dairy calves of different developmental quality and fitness (hemoglobin content of blood low HbG1, moderate HbG2 and high HbG3) at early gowth with uniform husbandry system on dairy calves (71 German Holstein Friesian, 6 German Red Pied, 36 male and 41 female) measurements were done before (5 days of age) and repeatedly at 15, 40 and 60 days of age when ca

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16

Ho, Leong Chuan, Ponnivalavan Babu, Rajnish Kumar, and Praveen Linga. "HBGS (hydrate based gas separation) process for carbon dioxide capture employing an unstirred reactor with cyclopentane." Energy 63 (December 2013): 252–59. http://dx.doi.org/10.1016/j.energy.2013.10.031.

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17

Babu, Ponnivalavan, Praveen Linga, Rajnish Kumar, and Peter Englezos. "A review of the hydrate based gas separation (HBGS) process for carbon dioxide pre-combustion capture." Energy 85 (June 2015): 261–79. http://dx.doi.org/10.1016/j.energy.2015.03.103.

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18

Pattillo, Robin E., and L. Bruce Gladden. "Red blood cell lactate transport in sickle disease and sickle cell trait." Journal of Applied Physiology 99, no. 3 (2005): 822–27. http://dx.doi.org/10.1152/japplphysiol.00235.2005.

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This study determined and compared rates and mechanisms of lactate transport in red blood cells (RBCs) of persons with 1) sickle cell disease (HbSS), 2) sickle cell trait (HbAS), and 3) a control group (HbAA). Blood samples were drawn from 30 African-American volunteers (10 HbSS, 10 HbAS, 10 HbAA). Lactate influx into RBCs was measured by using [14C]lactate at six (2, 5, 10, 15, 25, and 40 mM) unlabeled lactate concentrations. The monocarboxylate transporter pathway was blocked by p-chloromercuriphenylsulfonic acid to determine its percent contribution to total lactate influx. Generally, total

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19

Wu, Qiang, and Bao Yong Zhang. "Memory Effect Stability on Hydrate-Based Coal Mine Methane Separation for Reducing Direct CMM Emission." Advanced Materials Research 113-116 (June 2010): 897–903. http://dx.doi.org/10.4028/www.scientific.net/amr.113-116.897.

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A new hydrate-based gas separation (HBGS) method for recovering methane from low-concentration CMM was proposed. The objective of this study is to investigate the influence of the temperature increase, agitation, and pressure drop on the stability of memory effect. Results showed that (1) when the dissociation temperature is not higher than 25.00 °C, the decreases of subcooling and induction time in gas hydrate nucleation range from 0.16 to 1.06 °C, and 1.75 to 88.92min, respectively. But when the dissociation temperature is higher than 25.00 °C, the memory effect is destroyed notably; (2) the

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Zhou, Ning, Pinggang Jia, Jia Liu, et al. "MEMS-Based Reflective Intensity-Modulated Fiber-Optic Sensor for Pressure Measurements." Sensors 20, no. 8 (2020): 2233. http://dx.doi.org/10.3390/s20082233.

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A reflective intensity-modulated fiber-optic sensor based on microelectromechanical systems (MEMS) for pressure measurements is proposed and experimentally demonstrated. The sensor consists of two multimode optical fibers with a spherical end, a quartz tube with dual holes, a silicon sensitive diaphragm, and a high borosilicate glass substrate (HBGS). The integrated sensor has a high sensitivity due to the MEMS technique and the spherical end of the fiber. The results show that the sensor achieves a pressure sensitivity of approximately 0.139 mV/kPa. The temperature coefficient of the proposed

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Wan, Syahirah W. Samsudin, Samad Rosdiyana, Sundaraj Kenneth, Mustafa Mahfuzah, and Rul Hasma Abdullah Nor. "Correlation of Objective Assessment of Facial Paralysis with House-Brackmann Score." TELKOMNIKA Telecommunication, Computing, Electronics and Control 15, no. 2 (2017): 829–35. https://doi.org/10.12928/TELKOMNIKA.v15i2.6128.

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This article illustrated a brief review of some objective methods in assessing facial nerve function for facial nerve paralysis which were correlated with House-Brackmann Grading System (HBGS). A rigorous search of online databases such as Springer, Elsevier and IEEE was conducted from June, 2015 to November, 2016 to discover and analyze the previous works in facial nerve assessment methods for facial paralysis. Several domains such as facial grading system and methods used to evaluate the facial nerve function were extracted for further analysis. Different keywords were used to acquire the st

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Leuthold, Mila M., Kevin P. Dalton, and Grant S. Hansman. "Structural Analysis of a Rabbit Hemorrhagic Disease Virus Binding to Histo-Blood Group Antigens." Journal of Virology 89, no. 4 (2014): 2378–87. http://dx.doi.org/10.1128/jvi.02832-14.

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ABSTRACTRabbit hemorrhagic disease virus (RHDV) is a member of theCaliciviridaefamily (Lagovirusgenus). RHDV is highly contagious and attaches to epithelial cells in the digestive or respiratory tract, leading to massive lesions with high mortality rates. A new variant of RHDV (termed RHDVb) recently has emerged, and previously vaccinated rabbits appear to have little protection against this new strain. Similar to human norovirus (Caliciviridae,Norovirusgenus), RHDV binds histo-blood group antigens (HBGAs), and this is thought to be important for infection. Here, we report the HBGA binding sit

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Sánchez-Araiza, M., Stéphane Godet, Pascal J. Jacques, and John J. Jonas. "Effect of Hot Band Grain Size on the Anisotropy of Warm Rolled Low Carbon Steels." Materials Science Forum 500-501 (November 2005): 787–94. http://dx.doi.org/10.4028/www.scientific.net/msf.500-501.787.

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In warm rolled steels, the intensity of the <111>//ND annealing texture, which favours formability, has been related to the formation of shear bands during rolling. Coarse hot band grain sizes (HBGS’s) facilitate flow localization, the mechanism associated with the formation of shear bands.In this work, the effect of grain size after hot rolling was studied in a low carbon steel containing small additions of Cr and Mn. The formation of shear bands and their subsequent influence on the normal anisotropy rm and planar anisotropy Dr in the annealed steels were of particular interest. Two HB

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LeBari Barine Gboeloh, Edith Wordu, and Appollus Ebenezer Josiah. "Relationship between malaria parasitemia and haemoglobin variants in patients attending Rivers State University Teaching Hospital, Port Harcourt, Rivers State, Nigeria." Open Access Research Journal of Life Sciences 4, no. 1 (2022): 016–26. http://dx.doi.org/10.53022/oarjls.2022.4.1.0057.

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Malaria parasitemia and haemoglobin variants in patients attending Rivers State University Teaching Hospital, Port Harcourt, Rivers State, Nigeria was investigated. Blood samples from 385 patients attending the hospital were collected using sterile syringes into well labelled specimen bottles containing ethylene di-amine tetra acetate (EDTA). The genotype was determined using standard alkaline cellulose acetate electrophoretic technique while standard method was used to determine malaria parasitaemia. Out of the 385 patients examined for haemoglobin variants, the frequency of the genotype was

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Alsultan, Abdulrahman, Idowu Akinsheye, Nadia Solovieff, et al. "Fetal Hemoglobin In Sickle Cell Anemia: Molecular Characterization of Saudi Patients From the Eastern Province." Blood 116, no. 21 (2010): 1627. http://dx.doi.org/10.1182/blood.v116.21.1627.1627.

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Abstract Abstract 1627 In the Eastern Province of Saudi Arabia, sickle cell anemia (HbSS) is associated with the Saudi Indian (SI) HBB-gene cluster haplotype, high levels of fetal hemoglobin (HbF) and milder disease, when compared with Southwestern Province HbSS patients who have lower HbF levels and different HBB haplotypes. An association between HbF and the Xmn1 restriction site in the HBG2 promoter present in both the SI and African-derived Senegal haplotypes is well known, but the causal elements of this association are unknown. Moreover, among individuals with the SI haplotype, only HbSS

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Schroten, Horst, Franz-Georg Hanisch, and Grant S. Hansman. "Human Norovirus Interactions with Histo-Blood Group Antigens and Human Milk Oligosaccharides." Journal of Virology 90, no. 13 (2016): 5855–59. http://dx.doi.org/10.1128/jvi.00317-16.

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Human noroviruses interact with both human histo-blood group antigens (HBGAs) and human milk oligosaccharides (HMOs). The former are believed to be important for a virus infection, while the latter might act as natural decoys in the host during an infection. However, certain noroviruses are known to bind poorly to HBGAs and yet still cause infections; some interact with numerous HBGA types but are nonprevalent; and yet others bind HBGAs and seem to be increasing in prevalence. HBGAs and HMOs can be found as soluble antigens in humans, can be structurally alike, and can interact with equivalent

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Mukendi Kambala, Jean Pierre Kambala, Camila de Oliveira Silva e Souza, Olena Kamenyeva, et al. "Schistosome Infection in the Humanized Mouse Model of Sickle Cell Disease." Blood 142, Supplement 1 (2023): 5266. http://dx.doi.org/10.1182/blood-2023-178910.

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Introduction Sickle cell disease (SCD) is a hemoglobinopathy due to a single amino acid substitution in the β-chain of hemoglobin (Hb), in which glutamic acid is substituted by valine. The individuals carrying the substitution on both β-chains (HbSS) develop the disease, characterized by chronic hemolytic anemia, systemic inflammatory state, and development of acute painful vaso-occlusive crises. Globally distributed, the disease has its highest incidence in sub-Saharan Africa (SSA), where its superimposes with the distribution of infections by parasitic worms, including schistosomes. However,

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Patel, Dilip Kumar, Ranjeet Singh Mashon, Prasanta Purohit, et al. "INFLUENCE OF SICKLE CELL GENE ON THE ALLELIC DIVERSITY AT THE MSP-1 LOCUS OF PLASMODIUM FALCIPARUM IN ADULT PATIENTS WITH SEVERE MALARIA." Mediterranean Journal of Hematology and Infectious Diseases 7 (August 24, 2015): e2015050. http://dx.doi.org/10.4084/mjhid.2015.050.

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Although several studies have supported that sickle cell trait (HbAS) protects against falciparum malaria, the exact mechanism by which sickle gene confers protection is unclear. Further, there is no information on the influence of sickle gene on parasitic diversity of P. falciparum population in severe symptomatic malaria. This study was undertaken to assess the effect of the sickle gene on the parasite densities and diversities in hospitalized adult patients with severe falciparum malaria. The study was carried out in 166 adult hospitalized subjects with severe falciparum malaria at Sickle C

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Liang, Yu, Wei Bu Wang, Jing Zhang, et al. "Evolution of the interactions between GII.4 noroviruses and histo-blood group antigens: Insights from experimental and computational studies." PLOS Pathogens 17, no. 7 (2021): e1009745. http://dx.doi.org/10.1371/journal.ppat.1009745.

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Norovirus (NoV) is the major pathogen causing the outbreaks of the viral gastroenteritis across the world. Among the various genotypes of NoV, GII.4 is the most predominant over the past decades. GII.4 NoVs interact with the histo-blood group antigens (HBGAs) to invade the host cell, and it is believed that the receptor HBGAs may play important roles in selecting the predominate variants by the nature during the evolution of GII.4 NoVs. However, the evolution-induced changes in the HBGA-binding affinity for the GII.4 NoV variants and the mechanism behind the evolution of the NoV-HBGA interacti

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Chatel, Benjamin, Laurent A. Messonnier, Christophe Vilmen, Monique Bernard, Vincent Pialoux, and David Bendahan. "Exacerbated metabolic changes in skeletal muscle of sickle cell mice submitted to an acute ischemia–reperfusion paradigm." Clinical Science 132, no. 19 (2018): 2103–15. http://dx.doi.org/10.1042/cs20180268.

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Sickle cell disease (SCD) is characterized by painful vaso-occlusive crisis. While there are several metabolic abnormalities potentially associated with muscular ischemia–reperfusion cycles that could be harmful in the context of SCD, the metabolic consequences of such events are still unknown. Ten controls (HbAA), thirteen heterozygous (HbAS), and ten homozygous (HbSS) SCD mice were submitted to a standardized protocol of rest–ischemia–reperfusion of the left leg during which adenosine triphosphate, phosphocreatine, and inorganic phosphate concentrations as well as intramuscular pH were measu

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Singh, Bishal K., Mila M. Leuthold, and Grant S. Hansman. "Human Noroviruses' Fondness for Histo-Blood Group Antigens." Journal of Virology 89, no. 4 (2014): 2024–40. http://dx.doi.org/10.1128/jvi.02968-14.

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ABSTRACTHuman noroviruses are the dominant cause of outbreaks of gastroenteritis around the world. Human noroviruses interact with the polymorphic human histo-blood group antigens (HBGAs), and this interaction is thought to be important for infection. Indeed, synthetic HBGAs or HBGA-expressing enteric bacteria were shown to enhance norovirus infection in B cells. A number of studies have found a possible relationship between HBGA type and norovirus susceptibility. The genogroup II, genotype 4 (GII.4) noroviruses are the dominant cluster, evolve every other year, and are thought to modify their

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Man, Yuncheng, Zoe Sekyonda, Karamoja Monchamp, et al. "Hypoxia Impact on Red Blood Cell-Mediated Microvascular Occlusion and Adhesion in Sickle Cell Disease and Sickle Cell Trait." Blood 138, Supplement 1 (2021): 966. http://dx.doi.org/10.1182/blood-2021-149121.

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Abstract Introduction: Sickle cell disease (SCD) is a recessively inherited anemia caused by a single gene mutation leading to sickle hemoglobin production. Sickle cell trait (SCT) is the carrier state. Abnormal hemoglobin polymerization and resultant red blood cell (RBC) sickling, decreased deformability and increased adhesion, are well-known features of homozygous SCD. However, the overall pathophysiological impact of SCT on the RBC remains incompletely characterized. Here we use microfluidic techniques designed by us, the OcclusionChip and SCD Biochip (previously published), and commerciall

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Asomaning, Nancy, Xunde Wang, Maureen Lundt, et al. "Evaluation of Red Cell Deformability in Sickle Cell Disease Patients, Sickle Cell Carriers, and Healthy Controls Using Lorrca-Derived Parameters." Blood 142, Supplement 1 (2023): 5262. http://dx.doi.org/10.1182/blood-2023-184834.

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BACKGROUND Red blood cell (RBC) deformability plays a critical role in RBC elongation and viscosity, and when reduced, perfusion of peripheral tissues and oxygen delivery are impaired. Intracellular ATP maintains water and ion homeostasis in RBCs; reduced ATP leads to water and ion loss, dehydration and loss of RBC elasticity. RBC dehydration increases mean corpuscular hemoglobin concentration (MCHC) and also affects distribution of RBC width (RDW). Patients with sickle cell disease (SCD) have reduced RBC ATP, and markedly reduced RBC deformability when compared to healthy individuals. Here, w

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Kanne, Celeste K., Danielle Guffey, Charles Minard, et al. "Red Cell Rheology Biomarkers to Assess Cure in Gene-Based Therapies." Blood 136, Supplement 1 (2020): 11–12. http://dx.doi.org/10.1182/blood-2020-138989.

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Introduction Red cell rheology is abnormal in sickle cell disease (SCD); red blood cells (RBC) are rigid, dense, and the sickle hemoglobin (HbS) polymerizes with deoxygenation. There are several devices commercially available and under development to assess RBC rheology. One is an oxygen gradient ektacytometer (Lorrca with Oxygenscan, RR Mechatronics) which measures RBC deformability under oxygenated conditions (EImax) and deoxygenated conditions (EImin), and the oxygen concentration at which deformability begins to worsen, point of sickling (PoS). A commercially available hematology analyzer,

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Weichert, Stefan, Anna Koromyslova, Bishal K. Singh, et al. "Structural Basis for Norovirus Inhibition by Human Milk Oligosaccharides." Journal of Virology 90, no. 9 (2016): 4843–48. http://dx.doi.org/10.1128/jvi.03223-15.

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Histo-blood group antigens (HBGAs) are important binding factors for norovirus infections. We show that two human milk oligosaccharides, 2′-fucosyllactose (2′FL) and 3-fucosyllactose (3FL), could block norovirus from binding to surrogate HBGA samples. We found that 2′FL and 3FL bound at the equivalent HBGA pockets on the norovirus capsid using X-ray crystallography. Our data revealed that 2′FL and 3FL structurally mimic HBGAs. These results suggest that 2′FL and 3FL might act as naturally occurring decoys in humans.

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Lagoo, Jyoti, and Arpita Lagoo. "The study of the incidence of pregnant women with sickle cell disease." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 8, no. 10 (2019): 3950. http://dx.doi.org/10.18203/2320-1770.ijrcog20194360.

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Background: The sickle cell disease is major public health problem which causes high morbidity and mortality in India. It is observed that SCD is scourge in Chhattisgarh since long past. Sickle cell disease is a term for a group of genetically inherited disorders characterized by production of abnormal hemoglobin. “Hemoglobin-S” results from a point mutation in the beta globin gene. The main objective is to study the incidence of pregnant women with sickle cell disease.Methods: It is a hospital based prospective study. It was conducted at Obstetrics and Gynecology department of LTBRKM Govt. Me

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Sarafian, Victoria, Dorian Dikov, and Milen Karaivanov. "Modulating expression of LAMPs and ABH histo-blood group antigens in normal and neoplastic human skin." Open Medicine 1, no. 2 (2006): 119–27. http://dx.doi.org/10.2478/s11536-006-0012-0.

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AbstractAlthough the precise biological role of lysosomal membrane-associated glycoproteins (LAMPs) and ABH histo-blood group antigens (HBGAs) remains somewhat unclear, they are thought to be related to cell differentiation, cellular adhesion, and tumorigenesis. Here, we present the first comparative immunohistochemical study of both LAMPs and HBGAs in normal and neoplastic skin. Their localization is compared to that of high molecular weight cytokeratin and cytokeratin MNF 116. LAMPs and HBGA were differentially expressed in the normal stratified squamous epithelium, suggesting that they are

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Oshabaheebwa, Solomon, Christopher A. Delianides, Zoe Sekyonda, et al. "A Miniaturized, Rapid Technique for Measuring Red Blood Cell-Mediated Microcapillary Occlusion in HbAS, HbSC, and HbSS Sickle Cell Disease Genotypes." Blood 142, Supplement 1 (2023): 5022. http://dx.doi.org/10.1182/blood-2023-187259.

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Introduction Sickle cell disease (SCD) is caused by a genetic mutation that produces sickle hemoglobin (HbS). HbS polymerizes upon deoxygenation, causing red blood cells (RBCs) to become sickle-shaped and poorly deformable. Stiff sickle RBCs contribute to microvascular occlusion and organ damage. Previous studies have developed microfluidic devices for assessing RBC-mediated occlusion under hypoxia, but the complexity of the setup and data acquisition limits their adoption. A rapid, easy-to-use, point-of-care assay for assessing RBC-mediated occlusion could increase throughput and aid in deter

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Babu, Ponnivalavan, Rajnish Kumar, and Praveen Linga. "Medium pressure hydrate based gas separation (HBGS) process for pre-combustion capture of carbon dioxide employing a novel fixed bed reactor." International Journal of Greenhouse Gas Control 17 (September 2013): 206–14. http://dx.doi.org/10.1016/j.ijggc.2013.05.010.

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Tumburu, Laxminath, Maliha Maryam Ahmad, Chunyu Liu, Clifton L. Dalgard, Mehdi Pirooznia, and Swee Lay Thein. "Individuals with Sickle Cell Disease Have a Higher Burden of Mitochondrial DNA Heteroplasmy." Blood 138, Supplement 1 (2021): 954. http://dx.doi.org/10.1182/blood-2021-153000.

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Abstract Background: The simple point mutation that causes sickle cell disease (SCD) belies the extensive systemic damage it can cause. While the sickle pathology is initiated by polymerization of HbS, the multiple end-organ damage is inflicted by years of on-going inflammation and vasculopathy. An emerging marker of inflammation is the accumulation of acquired heteroplasmy mutations in mitochondrial DNA (mtDNA). Given the underlying chronic inflammation in SCD, we hypothesized that SCD patients display increased rates of mtDNA mutations, and previously confirmed (1). Here, we further performe

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Yang, Yang, Ming Xia, Ming Tan, et al. "Genetic and Phenotypic Characterization of GII-4 Noroviruses That Circulated during 1987 to 2008." Journal of Virology 84, no. 18 (2010): 9595–607. http://dx.doi.org/10.1128/jvi.02614-09.

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ABSTRACT The predominance and continual emergence of new variants in GII-4 noroviruses (NVs) in recent years have raised questions about the role of host immunity and histo-blood group antigens (HBGAs) in NV evolution. To address these questions, we performed a genetic and phenotypic characterization of GII-4 variants circulating in the past decade (1998 to 2008). Ninety-three GII-4 sequences were analyzed, and of them, 16 strains representing 6 genetic clusters were selected for further characterization. The HBGA binding properties were determined by both saliva- and oligosaccharide-binding a

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Chatel, Benjamin, Laurent A. Messonnier, Christophe Hourdé, Christophe Vilmen, Monique Bernard, and David Bendahan. "Moderate and intense muscular exercises induce marked intramyocellular metabolic acidosis in sickle cell disease mice." Journal of Applied Physiology 122, no. 5 (2017): 1362–69. http://dx.doi.org/10.1152/japplphysiol.01099.2016.

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Sickle cell disease (SCD) is associated with an impaired oxygen delivery to skeletal muscle that could alter ATP production processes. The present study aimed to determine the effects of sickle hemoglobin (HbS) on muscle pH homeostasis in response to exercise in homozygous (HbSS, n = 9) and heterozygous (HbAS, n = 10) SCD (Townes) mice in comparison to control (HbAA, n = 10) littermates. Magnetic resonance spectroscopy of phosphorus 31 enabled to measure intramuscular pH and phosphocreatine (PCr) concentration during rest-stimulation-recovery protocols at two different intensities. Maximal act

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Nnodim, Johnkennedy, VN Obi-Aziekwe, and U. Edward. "Evaluation of Anthropometric Parameters and Lipid Profile in Subjects with Sickle Cell Traits at Madonna University, Elele, Nigeria." Series of Clinical and Biomedical Research 1, no. 1 (2024): 1–7. http://dx.doi.org/10.54178/2997-2701.v1i1a1990.

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Sickle cell trait is a genetic condition that affects a substantial portion of the global population, particularly individuals of African descent. This study is aimed at evaluating anthropometric parameters and lipid profile parameters in subjects with sickle cell traits in Madonna University Teaching Hospital (MUTH), Elele. 72 subjects consisting of 30 HbAA (control), 21 HbAS, and 21 HbSS, all aged 18–40 years, were recruited for the study. Ethical clearance and informed consent were duly obtained from those involved. Blood samples were collected via venipuncture. Total cholesterol (TCH), tri

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Cataldo, Giuseppe, Mary M. Lunzer, Donald A. Simone, et al. "Targeting Putative Mu Opioid/Chemokine Receptor Type 5 Heteromers Potently Attenuates Nociception in a Murine Model of Sickle Cell Disease." Blood 126, no. 23 (2015): 277. http://dx.doi.org/10.1182/blood.v126.23.277.277.

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Abstract Background: Sickle cell disease (SCD) is one of the world's most common inherited diseases, due to a point mutation in hemoglobin that leads to the polymerization of hemoglobin S, giving red blood cells (RBCs) their sickle shape. The hallmarks of SCD are hemolysis and vaso-occlusion. Vaso-occlusive crises (VOC) frequently occur in response to inflammatory and hypoxic conditions such as infections, surgery, etc. Pain is a major defining characteristic of SCD starting early in life and continuing throughout adulthood. VOC-induced pain can be chronic or episodic and unpredictable, requir

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Metais, Jean-Yves, Phillip A. Doerfler, Thiyagaraj Mayuranathan та ін. "CRISPR-Cas9 Genome Editing of γ-Globin Promoters in Human Hematopoietic Stem Cells to Induce Erythrocyte Fetal Hemoglobin for Treatment of β-Hemoglobinopathies". Blood 134, Supplement_1 (2019): 2066. http://dx.doi.org/10.1182/blood-2019-131318.

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Induction of fetal hemoglobin (HbF, α2γ2) via genome editing-mediated disruption of DNA regulatory elements that repress expression of γ-globin genes (HBG1 and HBG2) is a promising therapeutic strategy for b-hemoglobinopathies including sickle cell disease (SCD) and β-thalassemia. Optimal technical approaches and safety profiles are yet to be fully defined. We used CRISPR/Cas9 to target a DNA repressor element near the distal CCAAT box of the HBG1/HBG2 promoters. This region contains a "TGACC" motif recognized by BCL11A, a transcriptional repressor protein that regulates γ-to-β globin switch a

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Burgess, W. H., C. A. Dionne, J. Kaplow, et al. "Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase." Molecular and Cellular Biology 10, no. 9 (1990): 4770–77. http://dx.doi.org/10.1128/mcb.10.9.4770-4777.1990.

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Heparin-binding growth factors (HBGFs) bind to high-affinity cell surface receptors which possess intrinsic tyrosine kinase activity. A Mr 150,000 protein phosphorylated on tyrosine in response to class 1 HBGF (HBGF-1) was purified and partially sequenced. On the basis of this sequence, cDNA clones were isolated from a human endothelial cell library and identified as encoding phospholipase C-gamma. Phosphorylation of phospholipase C-gamma in intact cells treated with HBGF-1 was directly demonstrated by using antiphospholipase C-gamma antibodies. Thus, HBGF-1 joins epidermal growth factor and p

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Burgess, W. H., C. A. Dionne, J. Kaplow, et al. "Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase." Molecular and Cellular Biology 10, no. 9 (1990): 4770–77. http://dx.doi.org/10.1128/mcb.10.9.4770.

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Heparin-binding growth factors (HBGFs) bind to high-affinity cell surface receptors which possess intrinsic tyrosine kinase activity. A Mr 150,000 protein phosphorylated on tyrosine in response to class 1 HBGF (HBGF-1) was purified and partially sequenced. On the basis of this sequence, cDNA clones were isolated from a human endothelial cell library and identified as encoding phospholipase C-gamma. Phosphorylation of phospholipase C-gamma in intact cells treated with HBGF-1 was directly demonstrated by using antiphospholipase C-gamma antibodies. Thus, HBGF-1 joins epidermal growth factor and p

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Oxendine Harp, Keri, Alaijah Bashi, Felix Botchway, et al. "MicroRNAs miR-451a and Let-7i-5p Profiles in Circulating Exosomes Vary among Individuals with Different Sickle Hemoglobin Genotypes and Malaria." Journal of Clinical Medicine 11, no. 3 (2022): 500. http://dx.doi.org/10.3390/jcm11030500.

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Sickle cell disease (SCD) occurs when two alleles of mutated hemoglobin (HbS or HbC) are inherited (HbSS and HbSC) rather than one (HbAS or HbAC), which indicates a person carries the sickle cell trait. The high prevalence of these two alleles in Africa have been associated with reduced malaria susceptibility. Recent in vitro research has been shown that microRNAs (miRNAs) miR-451a and let-7i-5p are differentially expressed in HbSS erythrocytes compared to healthy controls (HbAA) and are overexpressed in Plasmodium-infected malaria erythrocytes. However, these miRNAs have not been fully examin

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Su, Kemin, Dale J. Bremer, Richard Jeannotte, Ruth Welti, and Celeste Yang. "Membrane Lipid Composition and Heat Tolerance in Cool-season Turfgrasses, including a Hybrid Bluegrass." Journal of the American Society for Horticultural Science 134, no. 5 (2009): 511–20. http://dx.doi.org/10.21273/jashs.134.5.511.

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Cool-season turfgrasses may experience heat stress during summer. Hybrid bluegrasses (HBGs), crosses between kentucky bluegrass [KBG (Poa pratensis L.)] and native texas bluegrass (Poa arachnifera Torr.), have improved heat tolerance but the mechanisms of heat tolerance are poorly understood. Our objectives were to quantitatively profile membrane lipid molecular species in three cool-season turfgrasses exposed to optimal (22/15 °C, 14/10 h light/dark) and supra-optimal temperatures (35/25 °C and 40/30 °C, 14/10 h light/dark). Grasses included a low heat-tolerant tall fescue [TF (Festuca arundi

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Miccio, Annarita, та Gerd A. Blobel. "Role of the GATA-1/FOG-1/NuRD Pathway in the Expression of Human β-Like Globin Genes". Molecular and Cellular Biology 30, № 14 (2010): 3460–70. http://dx.doi.org/10.1128/mcb.00001-10.

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ABSTRACT The human β-globin genes are expressed in a developmentally controlled fashion. Studies on the molecular mechanisms underlying the stage-specific regulation of globin genes have been fueled by the clinical benefit of elevated fetal γ-globin expression in patients with sickle cell anemia and thalassemia. Recent reports suggested a role of the hematopoietic transcription factor GATA-1, its cofactor FOG-1, and the associated chromatin remodeling complex NuRD in the developmental silencing of HBG1 and HBG2 gene expression. To examine whether FOG-1 via NuRD controls HBG1 and HBG2 silencing

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