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Journal articles on the topic 'HCU database'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

Hajek, André, Benedikt Kretzler, and Hans-Helmut König. "Personality, Healthcare Use and Costs—A Systematic Review." Healthcare 8, no. 3 (2020): 329. http://dx.doi.org/10.3390/healthcare8030329.

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Background: Thus far, there is a lack of a systematic review synthesizing empirical studies that analyze the link between personality factors and healthcare use (HCU) or costs. Consequently, the purpose of our systematic review is to give an overview of empirical findings from observational studies examining the association between personality factors and HCU or costs. Methods: PubMed, PsycINFO, and NHS EED (NHS Economic Evaluation Database) were searched. Observational studies examining the association between personality factors and HCU costs by using validated tools were included. Two revie

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Von den Hoff, Daan W., Floor A. C. Berden, Femke Atsma, Arnt F. A. Schellekens, and Joost P. H. Drenth. "Against All Odds? Addiction History Associated with Better Viral Hepatitis Care: A Dutch Nationwide Claims Data Study." Journal of Clinical Medicine 11, no. 4 (2022): 1146. http://dx.doi.org/10.3390/jcm11041146.

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The elimination of viral hepatitis in target populations is crucial in reaching WHO viral hepatitis elimination goals. Several barriers for the treatment of viral hepatitis in people with addictive disorders have been identified, yet nationwide data on hepatitis healthcare utilization (HCU) in these patients are limited. We investigated whether a history of addictive disorder is associated with suboptimal hepatitis HCU, indicating failure to receive diagnostic care or treatment. We identified all newly referred viral hepatitis patients in the Netherlands between 2014 and 2019 by query of the D

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Umegaki, Takeshi, Kota Nishimoto, and Takahiko Kamibayashi. "Associations of the staffing structure of intensive care units and high care units on in-hospital mortality among patients with sepsis: a cross-sectional study of Japanese nationwide claims data." BMJ Open 14, no. 7 (2024): e085763. http://dx.doi.org/10.1136/bmjopen-2024-085763.

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ObjectiveThe objective was to analyse the associations of intensive care unit (ICU) and high care unit (HCU) organisational structure on in-hospital mortality among patients with sepsis in Japan’s acute care hospitals.DesignMulticentre cross-sectional study.SettingsPatients with sepsis aged ≥18 years who received critical care in acute care hospitals throughout Japan between April 2018 and March 2019 were identified using the National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB).InterventionsNone.Participants10 968 patients with sepsis were identified. ICUs w

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Movahedi, Mohammad, Angela Cesta, Xiuying Li, Mark Robert Tatangelo, and Claire Bombardier. "Healthcare utilization among patients with rheumatoid arthritis, with and without herpes zoster, a retrospective administrative data linked cohort study." PLOS One 20, no. 5 (2025): e0323229. https://doi.org/10.1371/journal.pone.0323229.

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Background Herpes zoster (HZ) infection is a significant concern among seniors and immunosuppressed patients including those with rheumatoid arthritis (RA). We aimed to compare healthcare utilization (HCU) and mortality in RA patients with and without HZ. Methods Patients from the Ontario Best Practices Research Initiative (OBRI) a clinical cohort (2008–2020) were linked to the Institute for Clinical Evaluative Sciences (ICES), a population health database. Each HZ patient was matched to four non-HZ patients based on sex, age, and HZ diagnosis date. The incidence of primary (HCU including hosp

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Movahedi, Mohammad, Angela Cesta, Xiuying Li, Mark Tatangelo, Claire Bombardier, and Janet Pope. "Health Care Utilization and Cost of Herpes Zoster Infection in Patients with Rheumatoid Arthritis, A Retrospective Cohort Study." Journal of Rheumatology 52, Suppl 2 (2025): 63.3–64. https://doi.org/10.3899/jrheum.2025-0314.42.

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ObjectivesPatients with rheumatoid arthritis (RA) have approximately a twofold increased risk of developing herpes zoster (HZ) compared to the general population. This elevated risk is attributed to the disease itself and related. We aimed to measure health care utilization (HCU) and related costs of HZ infections among RA patients from the health care payer perspective.MethodsPatients with RA were identified from the Ontario Rheumatoid Arthritis Database (ORAD), housed at ICES. Costs were measured from a single universal payer (Ontario Health Insurance Plan). We included all adult patients di

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Satwani, Prakash, Ruta Brazauskas, Staci D. Arnold, et al. "A Study of Predictors of Clinical Outcomes and Healthcare Utilization in Children with Sickle Cell Disease Undergoing Allogeneic Hematopoietic Cell Transplantation." Blood 126, no. 23 (2015): 528. http://dx.doi.org/10.1182/blood.v126.23.528.528.

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Abstract Introduction: Current advances in allogeneic hematopoietic cell transplant (alloHCT) may warrant a paradigm shift in managing children with sickle cell disease (SCD). This study characterizes the clinical outcomes and health care utilization (HCU) of alloHCT for pediatric SCD. We hypothesize that early alloHCT will have improved clinical outcomes, and decreased HCU. Methods: The Center for International Blood and Marrow Transplant Research database was used to identify children 21 years or less with alloHCT for SCD in the United States. Patient data included comprehensive research for

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Newman, Lawrence, Pamela Vo, Lujia Zhou, et al. "Health Care Utilization and Costs in Patients With Migraine Who Have Failed Previous Preventive Treatments." Neurology: Clinical Practice 11, no. 3 (2021): 206–15. http://dx.doi.org/10.1212/cpj.0000000000001076.

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ObjectiveTo characterize health care utilization (HCU) and associated costs among patients with migraine categorized by the number of preventive treatment failures (TFs; 1 TF, 2 TFs, and 3+ TFs) using real-world data.MethodsThis retrospective analysis identified adults with incident migraine diagnosis in the IBM MarketScan Commercial and Medicare Supplemental database between January 1, 2011, and June 30, 2015. TF was defined in the 2 years after the first migraine diagnosis period. One TF, 2 TFs, and 3+ TFs were defined as patients who had received only 2 preventive treatments (PTs), 3 PTs, a

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Takada, Yosuke, and Yasuhiro Otomo. "Study of Medical Supply and Demand Balance for the Nankai Trough Earthquake." Prehospital and Disaster Medicine 34, s1 (2019): s44. http://dx.doi.org/10.1017/s1049023x19001079.

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Introduction:The Nankai Trough, marking the boundary between the Eurasian Plate and the Philippine Sea Plate, is forecasted to create a tragic earthquake and tsunami within 30 years.Aim:To clarify the gap between medical supplies and demand.Methods:Collected the data of the estimation of injured persons from each prefecture throughout Japan, and also the number of Intensive Care Unit (ICU) and High Care Unit (HCU) beds in Japan from the Ministry of Health database. We re-calculated the number of severe cases based on official data. Moreover, we calculated the number of beds of hospitals with t

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Ouattara, Eric, Amelie Bruandet, Aurélie Borde, et al. "Risk factors of mortality among patients hospitalised with COVID-19 in a critical care or hospital care unit: analysis of the French national medicoadministrative database." BMJ Open Respiratory Research 8, no. 1 (2021): e001002. http://dx.doi.org/10.1136/bmjresp-2021-001002.

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ObjectiveTo explore mortality risk factors for patients hospitalised with COVID-19 in a critical care unit (CCU) or a hospital care unit (HCU).DesignRetrospective cohort analysis using the French national (Programme de médicalisation des systèmes d’information) database.SettingAny public or private hospital in France.Participants98 366 patients admitted with COVID-19 for more than 1 day during the first semester of 2020 were included. The underlying conditions were retrieved for all contiguous stays.Main outcome measuresIn-hospital mortality and associated risk factors were assessed using frai

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Metwally, Eman, Sharon Peacock Hinton, Jennifer Leigh Lund, Charles Poole, Brad Drummond, and Caroline A. Thompson. "Prevalence and timing of chronic obstructive pulmonary disease (COPD) diagnosis among patients newly diagnosed with lung cancer in the US." JCO Oncology Practice 19, no. 11_suppl (2023): 118. http://dx.doi.org/10.1200/op.2023.19.11_suppl.118.

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118 Background: COPD is one of the most common comorbidities among patients with lung cancer, and an important determinant of their survival. While COPD is frequently under diagnosed in the general population, less is known about the occurrence of COPD underdiagnosis in patients with lung cancer. Objectives: 1) To estimate prevalence and under diagnosis of COPD among patients newly diagnosed with lung cancer. 2) To quantify the association between timing of COPD diagnosis and stage of lung cancer at diagnosis and whether this association is modified by sex, race, and socioeconomic status (SES)

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Silviani, Sinta, Yanny Trisyani, and Etika Emaliyawati. "Manajemen Nyeri pada Pasien Penurunan Kesadaran di Ruang Perawatan Intensif : scooping review." MAHESA : Malahayati Health Student Journal 4, no. 11 (2024): 5046–59. http://dx.doi.org/10.33024/mahesa.v4i11.16099.

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ABSTRACT Pain is an unpleasant sensory and emotional experience resulting from tissue damage. Unconscious patients cannot directly communicate their pain to nurse, but this doesn’t meant they cannot feel pain. Pain in unconscious patients can arise from routine procedures such as prolonged immobilization to invasive procedures like surgery. Nursing interventions to manage pain are necessary to enhance patient comfort. This study aims to examine pain management in unconscious patients in the Intensive Care Unit. This type of research is a scoping review, searching for articles in the PubMed, SC

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Huang, Joanna C., Sudeep Karve, Sanchita Porwal, Kushan Thakkar, Thomas Marshall, and Tanja Rosenberg. "Health Care Utilization and Costs Among Patients with Chronic Myeloid Leukemia Using Tyrosine Kinase Inhibitors." Blood 132, Supplement 1 (2018): 3537. http://dx.doi.org/10.1182/blood-2018-99-113809.

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Abstract INTRODUCTION: Tyrosine kinase inhibitors (TKIs) remain mainstay in the management of patients with CML. Several TKIs have been approved over the last two decades. Even though efficacy and safety remain as the primary drivers in treatment selection, in recent years importance has been placed on treatment affordability and economic burden associated with the long-term cancer treatments such as TKIs. However, current literature lacks real-world data on healthcare utilization (HCU) and costs among patients with CML using TKIs, which this study aims to address. METHODS: Retrospective cohor

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Arnold, J. G., R. Srinivasan, T. S. Ramanarayanan, and M. DiLuzio. "Water resources of the Texas Gulf Basin." Water Science and Technology 39, no. 3 (1999): 121–33. http://dx.doi.org/10.2166/wst.1999.0151.

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A geographic information system (GIS) has been integrated with a distributed parameter, continuous time, nonpoint source pollution model SWAT (Soil and Water Assessment Tool) for the management of water resources. This integration has proven to be effective and efficient for data collection and to visualize and analyze the input and output of simulation models. The SWAT-GIS system is being used to model the hydrology of eighteen major river systems in the United States (HUMUS). This paper focuses on the integration of SWAT (basin scale hydrologic model) with the Geographical Resources Analysis

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Amir, Nur Rezky Rutami, Anis Khoirun Sauma, Kurnia Eryani, and Peppy dwi endraswari. "Hubungan Resistensi Antibiotik Pada Pasien Sepsis dan COVID-19 : Literatur Review." Jurnal Farmasi UIN Alauddin Makassar 12, no. 1 (2024): 9–18. http://dx.doi.org/10.24252/jfuinam.v12i1.42468.

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Pendahuluan: Penyakit COVID-19 yang disertai infeksi sekunder seperti sepsis harus segera ditangani dengan pemberian antibiotik yang sesuai dengan kondisi pasien untuk memulihkan hemodinamik pasien. Penggunaan antibiotik yang berlebihan, tidak tepat, dan tidak sesuai aturan pakai dapat menyebabkan resistensi antibiotik sehingga meningkatkan keparahan penyakit, terjadinya komplikasi, dan mortalitas.Tujuan Penelitian tinjauan pustaka ini bertujuan untuk mengetahui hubungan resistensi antibiotik yang diterapkan pada pasien sepsis dan COVID-19. Metode: Penelitian ini menggunakan dengan metode lite

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Sada, K. E., Y. Kojo, J. Fairburn-Beech, et al. "FRI0218 PREVALENCE, BURDEN OF DISEASE AND HEALTHCARE UTILIZATION AMONG PATIENTS WITH EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS (EGPA) IN JAPAN 2005-2017." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 692.1–693. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1658.

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Background:EGPA is a rare vasculitis condition with very limited data available from real-world settings on burden and health care utilization (HCU), particularly in Japan.Objectives:To estimate the prevalence (overall and age, gender stratified) and describe HCU and treatment patterns among Japanese EGPA patients.Methods:This was a retrospective descriptive cohort study using a large administrative claims database covering up to more than 5 million corporate employees and their dependents (JMDC claim database) in Japan. Annual prevalence from 2005-2017 was estimated using two EGPA case defini

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Gao, Yan, Yan Li, Ziyan Song, Zhenxing Jin, Xiao Li, and Chunluan Yuan. "Sortilin 1 Promotes Hepatocellular Carcinoma Cell Proliferation and Migration by Regulating Immune Cell Infiltration." Journal of Oncology 2022 (July 8, 2022): 1–13. http://dx.doi.org/10.1155/2022/6509028.

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Objectives. Recent evidence suggests that Sort1 promotes carcinogenesis and tumor progression in multiple types of cancers. This study investigates the role of Sort1 in hepatocellular carcinoma (HCC). Methods. The differentially expressed gene was screened through GEO and TCGA databases. The Sort1 gene was identified and its expression was then verified by TCGA and HCCDB (a database of hepatocellular carcinoma expression atlas) databases. The Human Protein Atlas database was used to assess the gene expression in tissues. The TCGA and KM-plotter databases were used to study the relationship bet

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Iwabuchi, Sadahiro, Kenta Takahashi, Kazunori Kawaguchi, et al. "Phospholipase A2 Group IIA Is Associated with Inflammatory Hepatocellular Adenoma." Cancers 16, no. 1 (2023): 159. http://dx.doi.org/10.3390/cancers16010159.

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Although benign hepatocellular adenomas (HCA) are very rare, recent observations have shown their occurrence in patients with diabetes mellitus. Consequently, most of these cases are treated by resection due to concerns regarding their potential progression to hepatocarcinoma (HCC). This decision is largely driven by the limited number of studies on HCC subtyping and the lack of molecular and biological insights into the carcinogenic potential of benign tumors. This study aimed to comprehensively investigate the subtype classification of HCA and to compare and analyze gene expression profiling

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Zeng, Lu, Xiude Fan, Xiaoyun Wang, et al. "Bioinformatics Analysis based on Multiple Databases Identifies Hub Genes Associated with Hepatocellular Carcinoma." Current Genomics 20, no. 5 (2019): 349–61. http://dx.doi.org/10.2174/1389202920666191011092410.

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Background: Hepatocellular carcinoma (HCC) is the most common liver cancer and the mechanisms of hepatocarcinogenesis remain elusive. Objective: This study aims to mine hub genes associated with HCC using multiple databases. Methods: Data sets GSE45267, GSE60502, GSE74656 were downloaded from GEO database. Differentially expressed genes (DEGs) between HCC and control in each set were identified by limma software. The GO term and KEGG pathway enrichment of the DEGs aggregated in the datasets (aggregated DEGs) were analyzed using DAVID and KOBAS 3.0 databases. Protein-protein interaction (PPI) n

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Yang, Wan-Xia, Yun-Yan Pan, and Chong-Ge You. "CDK1, CCNB1, CDC20, BUB1, MAD2L1, MCM3, BUB1B, MCM2, and RFC4 May Be Potential Therapeutic Targets for Hepatocellular Carcinoma Using Integrated Bioinformatic Analysis." BioMed Research International 2019 (October 13, 2019): 1–16. http://dx.doi.org/10.1155/2019/1245072.

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Hepatocellular carcinoma (HCC) is a malignant tumor with high mortality. The abnormal expression of genes is significantly related to the occurrence of HCC. The aim of this study was to explore the differentially expressed genes (DEGs) of HCC and to provide bioinformatics basis for the occurrence, prevention and treatment of HCC. The DEGs of HCC and normal tissues in GSE102079, GSE121248, GSE84402 and GSE60502 were obtained using R language. The GO function analysis and KEGG pathway enrichment analysis of DEGs were carried out using the DAVID database. Then, the protein–protein interaction (PP

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Jackson, Stewart, Scott Tyldesley, Barbara Baerg, and Ivo Olivotto. "Are the Creation and Maintenance of Databases in Healthcare Worthwhile? An Example of a Unique, Population-Based, Radiation Therapy Database." Healthcare Quarterly 15, no. 4 (2012): 71–77. http://dx.doi.org/10.12927/hcq.2012.23195.

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Thiyagarajan, G., Karunanithi Suganthi, Venkatachalapathy Lakshmanan, Sudhalakshmi Yamini, and G. Murugesan A. "Comparative In silico Analysis of Hypertrophic Cardiomyopathy Heart in Human and Normal Chicken Heart." Journal of Advanced Laboratory Research in Biology 1, no. 1 (2010): 60–63. https://doi.org/10.5281/zenodo.1317776.

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Hypertrophic Cardiomyopathy (HCM) is an incurable disease, which causes excessive thickening of the myocardium. HCM is caused by abnormalities in genes which code for the proteins responsible for contraction of the heart. The anatomical resemblances between the Chicken heart and HCM heart are thickening of the muscle of the left ventricle, localized ring- like thickening of muscle under the aortic valve, and poorly formed anterior ventricular groove, and left ventricle projecting beyond the right ventricle. The mutations for the genes are retrieved from the databases: Human Genome Mutation Dat

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Dai, Yaoyao, Sicheng Gao, Xing Liu, et al. "Effect of Aidi Injection plus TACE on Hepatocellular Carcinoma: A Meta-Analysis of Randomized Controlled Trials." Evidence-Based Complementary and Alternative Medicine 2018 (December 17, 2018): 1–10. http://dx.doi.org/10.1155/2018/9196409.

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We aim to conduct a meta-analysis of studies on the effect of Aidi injection combined with TACE in the treatment of hepatocellular carcinoma (HCC). China National Knowledge Infrastructure (CNKI), Wanfang Database, Chinese Biomedical Literature Database (CBM), Chinese Science and Technology Periodical Database (VIP), Allied and Complementary Medicine Database (AMED), EMBASE, Web of Science, PubMed, and Cochrane Library databases to October 1, 2017, were searched to collect the studies. The data analysis was performed using RevMan 5.3 software. Totally 20 clinical trials with 774 (the experiment

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Feng, Wei, and Shuo Han. "lncRNA ADAMTS9-AS1/circFN1 Competitively Binds to miR-206 to Elevate the Expression of ACTB, Thus Inducing Hypertrophic Cardiomyopathy." Oxidative Medicine and Cellular Longevity 2022 (March 31, 2022): 1–13. http://dx.doi.org/10.1155/2022/1450610.

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Hypertrophic cardiomyopathy (HCM) is a genetic cardiac disease and can result in substantial disability. The current study explored the potentials of long noncoding RNA- (lncRNA-) circular RNA- (circRNA-) microRNA- (miRNA-) messenger RNA (mRNA) networks in HCM. Firstly, HCM-related microarray data were procured from the GEO database, with differentially expressed genes (DEGs) obtained. HCM-related target genes were retrieved in combination with GeneCards and CTD databases, and candidate target genes were subsequently obtained by intersection screening. Further, an interaction network diagram o

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Bai, Yun, Dan Lu, Di Qu, et al. "The Role of ANGPTL Gene Family Members in Hepatocellular Carcinoma." Disease Markers 2022 (June 1, 2022): 1–14. http://dx.doi.org/10.1155/2022/1844352.

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Background. Hepatocellular carcinoma (HCC) is highly aggressive with a poor prognosis and survival rate. Certain ANGPTL members have been implicated in tumor progression. However, the relevance of the ANGPTL gene family to HCC remains poorly understood. In this study, we explored the role of ANGPTLs in the prognosis of HCC. Methods. From the CCLE database, we studied the expression of ANGPTLs in a range of cancer cell lines. The UCSC, HCCDB, and Human Protein Atlas databases were used to analyze the differences in mRNA and protein expression of ANGPTLs in HCC tissues. Additionally, the correla

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Wang, Qian, Yan Liang, Can Peng, and Peng Jiang. "Network Pharmacology-Based Study on the Mechanism of Scutellariae Radix for Hepatocellular Carcinoma Treatment." Evidence-Based Complementary and Alternative Medicine 2020 (October 26, 2020): 1–12. http://dx.doi.org/10.1155/2020/8897918.

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Hepatocellular carcinoma (HCC) is a malignant tumor without effective therapeutic drugs for most patients in advanced stages. Scutellariae Radix (SR) is a well-known anti-inflammatory and anticarcinogenic herbal medicine. However, the mechanism of SR against HCC remains to be clarified. In the present study, network pharmacology was utilized to characterize the mechanism of SR on HCC. The active components of SR and their targets were collected from the traditional Chinese medicine systems pharmacology database and the traditional Chinese medicine integrated database. HCC-related targets were

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Gheidarloo, Mahshid, Roya Kelishadi, Silva Hovsepian, Mojtaba Keikha, and Mahin Hashemipour. "The association between prenatal exposure to organochlorine compounds and neonatal thyroid hormone levels: a systematic review." Journal of Pediatric Endocrinology and Metabolism 33, no. 1 (2020): 21–33. http://dx.doi.org/10.1515/jpem-2019-0336.

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AbstractIn this systematic review, the association between prenatal exposure to organochlorine pesticides (OCPs) and neonatal thyroid hormone levels was studied. A systematic search of scientific literature was performed from the PubMed, SCOPUS and ISI web of science electronic bibliographic databases. The search strategy for the review was [(organochlorine OR “organochlorine pesticides” OR “organochlorine pollutants” OR “organochlorine pollutant”) AND (“thyroid hormone” OR triiodothyronine OR Thyroxine OR “fetal thyroid function” OR “thyroid function” OR “Thyroid Stimulating Hormone” AND “pre

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Liu, Shuqing, Lei Jia, Bing Quan, et al. "Coiled-Coil Domain-Containing Protein 45 Is a Potential Prognostic Biomarker and Is Associated with Immune Cell Enrichment of Hepatocellular Carcinoma." Disease Markers 2022 (December 29, 2022): 1–22. http://dx.doi.org/10.1155/2022/7745315.

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Objective. The role of coiled-coil domain-containing protein 45 (CCDC45) in the development of hepatocellular carcinoma (HCC) has not been reported. The present study is aimed at investigating the expression and prognosis of CCDC45 in HCC and its relevance to immune infiltration. Methods. We conducted CCDC45 expression analysis using The Cancer Genome Atlas (TCGA) tumor database, the Human Protein Atlas (HPA) database, and the Tumor Immunological Evaluation Resource (TIMER). We used the University of Alabama at Birmingham Cancer data analysis Portal (UALCAN) database to show the correlation of

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Wang, Shiying, Liping Zhuang, and Zhiqiang Meng. "Hepatocellular Carcinoma More Than 3 cm in Diameter: A Systematic Review of Transcatheter Arterial Chemoembolization Plus Percutaneous Ethanol Injection versus Transcatheter Arterial Chemoembolization Alone." ISRN Gastroenterology 2013 (June 27, 2013): 1–9. http://dx.doi.org/10.1155/2013/526024.

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Objective. To identify the efficiency and safety of transcatheter arterial chemoembolization (TACE) combined with percutaneous ethanol (PEI) for patients with hepatocellular carcinoma (HCC) more than 3 cm in diameter in comparison with those of transcatheter arterial chemoembolization monotherapy. Methods. All databases were searched up to February 22, 2013. The literature retrieval was conducted through Pubmed, Web of Science, and Cochrane Library. We also searched Chinese databases, including Chinese National Knowledge Infrastructure (CNKI), Chinese Biology Medicine (CBM), Wanfang database,

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Ju, Gaoda, Tianhao Zhou, Rui Zhang, Xiaozao Pan, Bing Xue, and Sen Miao. "DUSP12 regulates the tumorigenesis and prognosis of hepatocellular carcinoma." PeerJ 9 (August 3, 2021): e11929. http://dx.doi.org/10.7717/peerj.11929.

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Background Dual specificity protein phosphatase (DUSP)12 is an atypical member of the protein tyrosine phosphatase family, which are overexpressed in multiple types of malignant tumors. This protein family protect cells from apoptosis and promotes the proliferation and motility of cells. However, the pathological role of DUSP12 in hepatocellular carcinoma (HCC) is incompletely understood. Methods We analyzed mRNA expression of DUSP12 between HCC and normal liver tissues using multiple online databases, and explored the status of DUSP12 mutants using the cBioPortal database. The correlation bet

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Zhang, Pei, Lei Zhu, and Xiaodong Pan. "A comprehensive analysis of the oncogenic and prognostic role of TBC1Ds in human hepatocellular carcinoma." PeerJ 12 (May 14, 2024): e17362. http://dx.doi.org/10.7717/peerj.17362.

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Backgrounds TBC1D family members (TBC1Ds) are a group of proteins that contain the Tre2-Bub2-Cdc16 (TBC) domain. Recent studies have shown that TBC1Ds are involved in tumor growth, but no analysis has been done of expression patterns and prognostic values of TBC1Ds in hepatocellular carcinoma (HCC). Methods The expression levels of TBC1Ds were evaluated in HCC using the TIMER, UALCN and Protein Atlas databases. The correlation between the mRNA levels of TBC1Ds and the prognosis of patients with HCC in the GEPIA database was then analyzed. An enrichment analysis then revealed genes that potenti

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Chen, Miao, Duo Wang, Junjie Liu, et al. "MicroRNA-587 Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Targeting Ribosomal Protein SA." BioMed Research International 2020 (September 7, 2020): 1–12. http://dx.doi.org/10.1155/2020/3280530.

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Background. Hepatocellular carcinoma (HCC) is one of the most highly aggressive cancer worldwide with an extremely poor prognosis. Evidence has revealed that microRNA-587 (miR-587) is abnormally expressed in a series of cancers. However, its expressions and functions in HCC have not been clearly acknowledged. Methods. We detected the expression level of miR-587 both in the Gene Expression Omnibus (GEO) database and 86 paired clinical HCC tissues together with paired adjacent normal tissues by quantitative real-time PCR (qRT-PCR). Afterwards, the transfected HCC cell line SMMC-7721 cells were c

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Siddiqui, Mohammad Faridul Haque, Parashar Dhakal, Xiaoli Yang, and Ahmad Y. Javaid. "A Survey on Databases for Multimodal Emotion Recognition and an Introduction to the VIRI (Visible and InfraRed Image) Database." Multimodal Technologies and Interaction 6, no. 6 (2022): 47. http://dx.doi.org/10.3390/mti6060047.

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Multimodal human–computer interaction (HCI) systems pledge a more human–human-like interaction between machines and humans. Their prowess in emanating an unambiguous information exchange between the two makes these systems more reliable, efficient, less error prone, and capable of solving complex tasks. Emotion recognition is a realm of HCI that follows multimodality to achieve accurate and natural results. The prodigious use of affective identification in e-learning, marketing, security, health sciences, etc., has increased demand for high-precision emotion recognition systems. Machine learni

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Keller, Jesse W., Maria Majella Doyle, Andrea Wang-Gillam, et al. "Analysis of the genomic profile of biphenotypic tumors compared to cholangiocarcinoma and hepatocellular carcinoma." Journal of Clinical Oncology 32, no. 3_suppl (2014): 226. http://dx.doi.org/10.1200/jco.2014.32.3_suppl.226.

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226 Background: Biphenotypic (combined HCC/Cholangiocarcinoma) tumors represent a minority of primary liver cancers. While databases such as the Catalog of Somatic Mutations in Cancer (COSMIC) have genetic information on a large number of cases of HCC and Cholangiocarcinoma, there is little known about rarer Biphenotypic tumors. In this analysis we examine the results of targeted next-generation sequencing to assess genomic differences between these tumors. We utilize the COSMIC database for comparison. Methods: The database of theIRB-approved Washington University Hepatobiliary Registry ident

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SAGHEER, ALAA, NAOYUKI TSURUTA, RIN-ICHIRO TANIGUCHI, and SAKASHI MAEDA. "APPEARANCE FEATURE EXTRACTION VERSUS IMAGE TRANSFORM-BASED APPROACH FOR VISUAL SPEECH RECOGNITION." International Journal of Computational Intelligence and Applications 06, no. 01 (2006): 101–22. http://dx.doi.org/10.1142/s1469026806001800.

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In this paper we propose a new appearance based system which consists of two stages: visual speech feature extraction and classification, followed by recognition of the extracted feature, thereby the result is a complete lip-reading system. This lip-reading system employs our Hyper Column Model (HCM) approach to extract and classify the visual features and uses the Hidden Markov Model (HMM) for recognition. This paper addresses mainly the first stage; i.e. feature extraction and classification. We investigate the HCM performance to achieve feature extraction and classification and then compare

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Pero, Adriana, Keith Sigel, and Myron Schwartz. "48 Analyzing Changing Trends in Hepatocellular Carcinoma." Journal of Clinical and Translational Science 8, s1 (2024): 13. http://dx.doi.org/10.1017/cts.2024.59.

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OBJECTIVES/GOALS: To quantify changing trends in hepatocellular carcinoma (HCC) etiologies, mainly hepatitis C related HCC (HCV-HCC), nonalcoholic fatty liver disease related HCC (NAFLD-HCC), and alcoholic liver disease related HCC (ALD-HCC), at a single center as well as compared to large national databases. METHODS/STUDY POPULATION: This is a retrospective longitudinal study using a single-center database of patients presenting with HCC from January 1995 to September 2023. Etiologies were confirmed through patient history, clinical exam, and viral serologies. Trends in rate of etiology were

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Luo, Guanshui, Jianguo Xu, Zhenglin Xia, et al. "SSRP1 Is a Prognostic Biomarker Correlated with CD8+ T Cell Infiltration in Hepatocellular Carcinoma (HCC)." BioMed Research International 2021 (February 23, 2021): 1–10. http://dx.doi.org/10.1155/2021/9409836.

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Background. Hepatocellular carcinoma (HCC), one of the most common primary malignancies, is theoretically an epitope candidate for immune checkpoint inhibitors, and therefore, the identification of HCC biomarkers is important. Structure-specific recognition protein 1 (SSRP1) is involved in almost all chromatin-related processes, including DNA replication, repair, and transcription. However, its role in HCC remains to be elucidated. Methods. This study investigated the expression of SSRP1 in HCCDB, Oncomine, HPA, and other databases. The prognostic value of SSRP1 in HCC and its relationship wit

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Liu, Xuxu, Yuanhang He, Pengfei Wang, et al. "ANP32 Family as Diagnostic, Prognostic, and Therapeutic Biomarker Related to Immune Infiltrates in Hepatocellular Carcinoma." Disease Markers 2022 (March 3, 2022): 1–25. http://dx.doi.org/10.1155/2022/5791471.

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Hepatocellular carcinoma (HCC) is one of the most common tumors worldwide, with high incidence and mortality rate. There is an urgent need to identify effective diagnostic and prognostic biomarkers for HCC. Members of the acidic leucine-rich nucleophosphoprotein 32 (ANP32) family, which mainly includes ANP32A, ANP32B, and ANP32E, are abnormally expressed and have prognostic value in certain cancers. However, the diagnostic, prognostic, and therapeutic value of ANP32 family members in HCC has not yet been fully studied. In this study, we identified the diagnostic and prognostic value of ANP32 f

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Wu, Qing, Yangzhi Hu, Qinghui Ma, et al. "Comprehensive Analysis of RAPGEF2 for Predicting Prognosis and Immunotherapy Response in Patients with Hepatocellular Carcinoma." Journal of Oncology 2022 (April 26, 2022): 1–11. http://dx.doi.org/10.1155/2022/6560154.

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Background. Hepatocellular carcinoma (HCC) is the sixth most common tumor worldwide. Additionally, deletion of RAPGEF2 plays a critical role in CNV and related to tumor immune microenvironment, whereas the prognostic potential of RAPGEF2 in HCC patient needs to be explored. Methods. We looked for prognostic potential genes in HCC using a variety of R programs. Then, using the LASSO Cox regression, we thoroughly evaluated and integrated the RAPGEF2-related genes from TCGA database. Meanwhile, utilizing TCGA and ICGA databases, the link between RAPGEF2 and immunotherapy response in HCC was studi

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Wu, Qing, Yangzhi Hu, Qinghui Ma, et al. "Comprehensive Analysis of RAPGEF2 for Predicting Prognosis and Immunotherapy Response in Patients with Hepatocellular Carcinoma." Journal of Oncology 2022 (April 26, 2022): 1–11. http://dx.doi.org/10.1155/2022/6560154.

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Background. Hepatocellular carcinoma (HCC) is the sixth most common tumor worldwide. Additionally, deletion of RAPGEF2 plays a critical role in CNV and related to tumor immune microenvironment, whereas the prognostic potential of RAPGEF2 in HCC patient needs to be explored. Methods. We looked for prognostic potential genes in HCC using a variety of R programs. Then, using the LASSO Cox regression, we thoroughly evaluated and integrated the RAPGEF2-related genes from TCGA database. Meanwhile, utilizing TCGA and ICGA databases, the link between RAPGEF2 and immunotherapy response in HCC was studi

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Lu, Jingyi, Lu Tian, Yu-Man Tsui, et al. "Abstract 6982: The roles of NDRG1 in HCC progression and its clinical significance." Cancer Research 84, no. 6_Supplement (2024): 6982. http://dx.doi.org/10.1158/1538-7445.am2024-6982.

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Abstract Background: Hepatocellular carcinoma (HCC) is prevalent globally and the third leading cause of cancer-related mortality. N-myc downstream regulated 1 (NDRG1) was found to be tumor promoting in some cancers while suppressive in others. The expression of NDRG1 is induced by stress signals such as DNA damage and hypoxia. In HCC, it has been found to promote proliferation and metastasis. Contradictory results, however, were also suggested on the functions of NDRG1. Methods: Our own HCC cohort and multiple publicly available databases were examined for NDRG1 expression and clinicopatholog

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Li, Chuanfei, Feng Qin, Hao Hong, et al. "Identification of Flap endonuclease 1 as a potential core gene in hepatocellular carcinoma by integrated bioinformatics analysis." PeerJ 7 (September 6, 2019): e7619. http://dx.doi.org/10.7717/peerj.7619.

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Hepatocellular carcinoma (HCC) is a common yet deadly form of malignant cancer. However, the specific mechanisms involved in HCC diagnosis have not yet fully elucidated. Herein, we screened four publically available Gene Expression Omnibus (GEO) expression profiles (GSE14520, GSE29721, GSE45267 and GSE60502), and used them to identify 409 differentially expressed genes (DEGs), including 142 and 267 up- and down-regulated genes, respectively. The DAVID database was used to look for functionally enriched pathways among DEGs, and the STRING database and Cytoscape platform were used to generate a

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Zhang, Di, Liping Ye, Shuang Hu, Qingqing Zhu, Chenxi Li, and Chengming Zhu. "Comprehensive Analysis of the Expression and Prognostic Value of LMAN2 in HER2+ Breast Cancer." Journal of Immunology Research 2022 (June 6, 2022): 1–26. http://dx.doi.org/10.1155/2022/7623654.

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Lectin, Mannose Binding 2 (LMAN2) encodes a type I transmembrane lectin that shuttles between the plasma membrane, the Golgi apparatus, and the endoplasmic reticulum. However, its expression, prognosis, and function in invasive breast carcinoma remain unknown. Nine databases were consulted to evaluate LMAN2 expression and prognosis in breast cancer. The possible function of LMAN2 in breast cancer was investigated in the Human Cell Landscape (HCL) database, Gene Regulatory Network database (GRNdb), and CancerSEA database. Moreover, N6-methyladenosine (m6A) modifications were analyzed using the

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Huang, Xufeng, Hafiz Muzzammel Rehman, Attila Gábor Szöllősi, and Shujing Zhou. "Network Pharmacology-Based Approach Combined with Bioinformatic Analytics to Elucidate the Potential of Curcumol against Hepatocellular Carcinoma." Genes 13, no. 4 (2022): 653. http://dx.doi.org/10.3390/genes13040653.

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Purpose: Modern, open-source databases provide an unprecedented wealth of information to help drug development. By combining data available in these databases with the proper bioinformatical tools, we can elucidate the molecular targets of natural compounds. One such molecule is curcumol, a guaiane-type sesquiterpenoid hemiketal isolated from Rhizoma Curcumae, which is used for a broad range of diseases in traditional Chinese and Indian medicine. It has been reported to exert anti-tumor activity, but the intrinsic molecular mechanism in hepatocellular carcinoma (HCC) is unclear. Therefore, the

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Jones, Lauriann M., and Mustapha Mouloua. "A Student's Guide to HCI Research and Database Development." Proceedings of the Human Factors and Ergonomics Society Annual Meeting 49, no. 7 (2005): 774–77. http://dx.doi.org/10.1177/154193120504900707.

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This paper is intended to provide a useful guide and reference for those students (or researchers) attempting to familiarize themselves with the large body of HCI research available. This paper discusses trends, labs, funding sources, implications, and major contributions to HCI over the past decade (1995–2005) as documented through the British Journal of Behaviour & Information Technology. Several graphs are provided to illustrate patterns of interest and publication of HCI research with step-by-step guidance for the overwhelmed student (or researcher) for everything from narrowing releva

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Gao, Shan, Dongjie Zhu, Jian Zhu, Lianqiang Shen, Ming Zhu, and Xuefeng Ren. "Screening Hub Genes of Hepatocellular Carcinoma Based on Public Databases." Computational and Mathematical Methods in Medicine 2021 (October 26, 2021): 1–15. http://dx.doi.org/10.1155/2021/7029130.

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Tumor recurrence and metastasis often occur in HCC patients after surgery, and the prognosis is not optimistic. Hence, searching effective biomarkers for prognosis of is of great importance. Firstly, HCC-related data was acquired from the TCGA and GEO databases. Based on GEO data, 256 differentially expressed genes (DEGs) were obtained firstly. Subsequently, to clarify function of DEGs, clusterProfiler package was used to conduct functional enrichment analyses on DEGs. Protein-protein interaction (PPI) network analysis screened 20 key genes. The key genes were filtered via GEPIA database, by w

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Doleh, Yunes, Huifen Wang, Ping Sun, Binbing Yu, and Iksha Herr. "Epidemiology and characteristics of patients (pts) with hepatocellular carcinoma (HCC) and care in the United States." Journal of Clinical Oncology 37, no. 4_suppl (2019): 231. http://dx.doi.org/10.1200/jco.2019.37.4_suppl.231.

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231 Background: The incidence of liver and intrahepatic bile duct cancer, with HCC accounting for 72.7%, has doubled from 1992 to 2014 in the U.S. This study examined the latest epidemiology of HCC by analyzing 2 large U.S. databases. Methods: IBM MarketScan (IBM-MS) and Surveillance, Epidemiology, and End Results-National Program of Cancer Registries (SEER-NPCR) databases were analyzed separately. Pts (aged ≥ 18 years) with HCC as the primary cancer were identified from the IBM-MS database, who were covered by employer-provided commercial or Medicare Supplemental insurance. A new HCC diagnosi

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Yan, Dong, Chunxiao Li, Yantong Zhou, et al. "Exploration of Combinational Therapeutic Strategies for HCC Based on TCGA HCC Database." Oncologie 24, no. 1 (2022): 101–11. http://dx.doi.org/10.32604/oncologie.2022.020357.

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Brar, Gagandeep, Tim McNeel, Katherine McGlynn, et al. "Hepatocellular carcinoma (HCC) survival by etiology: A SEER-Medicare database analysis." Journal of Clinical Oncology 37, no. 4_suppl (2019): 201. http://dx.doi.org/10.1200/jco.2019.37.4_suppl.201.

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201 Background: HCC is the 6thmost common occurring cancer worldwide and the 4th leading cause of cancer mortality, with a survival of 6-9 months. While survival varies by stage at diagnosis and treatment, the effect of HCC etiology on survival is unclear. We analyzed the SEER-Medicare database to evaluate whether HCC survival varied by etiology, after adjusting for stage, treatment, and survival. Methods: A total of 11,522 SEER-Medicare HCC cases (ICD-O-3 codes C22 for topography, 8170-8175 for morphology) met criteria for the Cox proportional hazard analyses to assess survival differences am

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Amram, Talia, Or A. Duek, Inbal Golan‐Tripto, Aviv Goldbart, David Greenberg, and Guy Hazan. "The Interplay Between Respiratory Syncytial Virus and Asthma Inception: Insights Gained From the COVID‐19 Pandemic." Pediatric Pulmonology, January 6, 2025. https://doi.org/10.1002/ppul.27474.

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ABSTRACTBackgroundRespiratory syncytial virus (RSV) infection in the first year of life has been linked with an increased risk for asthma. Some propose that RSV‐induced inflammation leads to lasting airway changes, while others contend that RSV bronchiolitis is a marker for underlying predisposition. Social distancing adopted during the COVID‐19 pandemic has led to a dramatic reduction in RSV activity, providing an unexpected opportunity to investigate this debate.ObjectiveTo compare the incidence of asthma‐related healthcare‐utilization (HCU) in 1–3 years of age between children born in March

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Finkemeier, Christopher G., Chantal E. Holy, Jill W. Ruppenkamp, Mollie Vanderkarr, and C. Sparks. "Demographic and clinical profile of patients treated with proximal femoral nails – a 10-year analysis of more than 40,000 Cases." BMC Musculoskeletal Disorders 23, no. 1 (2022). http://dx.doi.org/10.1186/s12891-022-05772-1.

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Abstract Background Hip fractures are common in elderly populations and can be life threatening. Changes in healthcare delivery and outcomes for patients with hip fracture treated with intramedullary nails are not well characterized. The objectives of our study were: 1) the characterization of patients treated with the Trochanteric Fixation Nail -Advanced™(TFNA) Proximal Femoral Nailing System or comparable nails (index) and estimate 12-month all-cause readmissions (ACR) and reoperations following index; and 2) the evaluation of 10-year healthcare utilization (HCU) trends for treatment of femo

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