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Ernest, Sheila. "Genetic and Molecular Dissection of Homocysteinemia in Mice." Case Western Reserve University School of Graduate Studies / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=case1085436351.
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Alkhoury, Kenan. "Mechanisms responsible for homocysteine mediated damage to human endothelial cells : the role of oxidative stress in atherogenesis." Thesis, University of Bradford, 2009. http://hdl.handle.net/10454/4300.
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Homocysteine (Hcy) has been identified as a primary risk factor for atherosclerosis as it induces endothelial cell (EC) activation/dysfunction and thus potentially initiating atherosclerotic plaque formation. There is accumulating evidence indicating a key role for oxidative stress in mediating Hcy atherogenic effects. The aim of this study was to evaluate the effects of chronic treatment with Hcy on EC activation and to explore the role of oxidative stress in these effects. Human umbilical vein endothelial cells (HUVEC) were cultured and treated chronically with DL-Hcy for 5-9 days. An in vitro flow system was also used to characterize the different types of interactions between DL-Hcy-treated HUVEC and neutrophils under physiological flow conditions. EC activation was studied by characterizing the activation of the JNK pathway and the up-regulation of different cell adhesion molecules (CAM) and cytokines, using different techniques including western blot, immunohistochemical staining, enzyme-linked immunosorbent assay and polymerase chain reaction. The role of oxidative stress was investigated by measuring the production of ROS and evaluating the efficiency of antioxidants. Furthermore, the role of nitric oxide and nitric oxide synthase in modulating Hcy effects was investigated. Chronic treatment with DL-Hcy did not kill the EC however, it inhibited cell proliferation. Furthermore, this treatment induced EC activation/dysfunction which was characterized by sustained activation of the JNK pathway, which in turn mediated up-regulation of E-selectin, ICAM-1 and to lesser extent P-selectin. Furthermore, DL-Hcy induced production of IL-8 protein. These CAM and chemokines collectively mediated different interactions between DL-Hcy-treated HUVEC and neutrophils under flow conditions including tethering, rolling, adherence and transmigration. DL-Hcy was also shown to induce significant ROS generation which mediated activation of the JNK pathway. Antioxidants restored DL-Hcy-induced interactions under flow to the basal level. DL-Hcy was shown to induce eNOS uncoupling which mediated, at least in part, the DL-Hcy-induced ROS production. Furthermore, short term treatment with NO inhibited DL-Hcy-induced HUVEC:neutrophil interactions in a cGMP-independent manner. In summary, this research showed that DL-Hcy has several proatherogenic effects, mediated at least in part by the JNK pathway, and induces EC activation/dysfunction priming for atherosclerosis initiation. The data supports that oxidative stress mediates the majority of Hcy atherosclerotic effects. Antioxidants tested, JNK inhibitors and NO showed promising results in reversing all DL-Hcy effects and restoring EC normal status.
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Alles, Roxane. "Développement de nouveaux nanovecteurs pour les thérapies anti-HCV/HCC." Phd thesis, Université de Strasbourg, 2013. http://tel.archives-ouvertes.fr/tel-00998936.
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Ce travail concerne le développement d'un système de vectorisation nanoparticulaire pour l'interférence ARN, constituant une nouvelle proposition thérapeutique applicable à des pathologies virales ou tumorales, et possiblement complémentaire aux traitements existants. La vectorisation de siRNA est ici basée sur l'enrobage multicouche de nanoparticules de phosphate de calcium, la multicouche étant constituée de dépôts alternés de PEI modifié et de siRNA. Ce système permet d'obtenir une efficacité de transfection des cellulaires cibles supérieure à celle des procédés conventionnels et une rémanence fonctionnelle in vitro jusqu'à neuf jours. Les résultats d'interférence ARN obtenus ont permis notamment d'inhiber l'infection par le virus de l'hépatite C jusqu'à 99,95%, l'inhibition de l'expression d'une protéine intrinsèque jusqu'à90,5%, et le ralentissement de la croissance cellulaire dans un modèle 3D mimant une tumeur hépatique jusqu'à 46,5%. Ces nanoparticules pourraient présenter un intérêt majeur, en offrant une action à long terme et en résolvant la plupart des difficultés rencontrées en utilisant des siRNA en thérapie.
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Ahmed, Iqra Shahzadi. "Preventing the spread of Tuberculosis via refugees, asylum seekers and immigrants entering Sweden : A study of health communication, prevention strategies, policies and recommendations." Thesis, Södertörns högskola, Institutionen för naturvetenskap, miljö och teknik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-20183.
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Sverige har under många decennier sett en minskning av tuberkulos (TBC), men infektionen har kontinuerligt ökat från 2003. Majoriteten av TBC-fallen är personer som är födda utanför Sverige. Hälsotillståndet har förbättrats i Sverige men det finns fortfarande problem. Kommunikationen mellan flyktingar och sjukvårdsspecialister är bristande idag, vilket resulterar att endast ett fåtal genomgår hälsokontroller. Detta kan leda till en ökning av infektioner och sjukdomar i Sverige. Denna studie undersöker hur hälsokommunikationen idag fungerar mellan den svenska sjukvården, nyanlända immigranter, asylsökande och flyktingar, samt vilken typ av vård som finns tillgänglig för flyktingar med hög risk för att utveckla TBC. Specifikt syftar studien till att förstå på vilket sätt kommunikation brister på samt analysera vilka sätt det finns för att en reducering av TBC i Sverige ska kunna ske och hur kommunikationen kan förbättras. Studien har genomförts med hjälp av både primära källor i form av intervjuer och sekundära källor. Baserat på de intervjuer och sekundära källor som genomförts i studien dras slutsatsen att trots att den svenska sjukvården utvecklas positivt så finns det en hel del brister - hälsokommunikation är bristande idag mellan nyanlända flyktingar, sjukvårdspersonal och myndigheter. En av huvudorsakerna som informanterna i studien nämnt är språket, mycket av det som skrivs och sägs är på svenska. Det är viktigt att en mer välfungerad hälsokommunikation utvecklas mellan de nyanlända flyktingarna, sjukvårdspersonal och myndigheterna för att det ska kunna underlättas för flyktingar att söka vård och samarbeta med sjukvårdspersonal med deras arbete för att kunna förhindra spridning av TBC och andra sjukdomar och infektioner i Sverige.Sweden has for many decades witnessed a decrease of the spread of tuberculosis (TB), but between the years of 2003-2012 a new pattern has emerged with refugees carrying TB entering the country and contributing to a situation where the infection has slowly begun to spread again. The communication between the refugees and the health professionals has been inefficient, which inevitably results in fewer refugees undergoing health examinations. This in turn can lead to an increase of infections and diseases. The purpose of this study is to examine the current health communication between Swedish health professionals and immigrants, asylum seekers and refugees, and to give an overview of what type of health care currently exist for refugees with a high risk of TB. This is done to understand what is missing in the communication process, what has been done in order to improve the situation, and how it can be further improved in order to prevent TB. In order to fulfill the purpose of this study, a qualitative method has been used combining text analysis of interviews and secondary sources. This study has shown based on the interviews and secondary sources that the Swedish prevention work regarding TB is developing positively in general, but the communication between newly arrived refugees, health professionals and authorities in Sweden is lacking due to the fact that most of what is written and said in this communication process is in Swedish. This makes it difficult for the refugees to understand what is communicated and is stated as one of the main reasons why many refugees do not undergo health examinations, combined with the lack of awareness. Therefore a better functioning health communication between refugees, authorities and health professionals is required to support refugees seeking health care, as well as co-operating with health professionals to prevent the spread of not only TB but other infections and diseases in Sweden.
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El-Nady, Ghada Maghawry Abdel-Latif. "Gene expression in HCV-associated HCC-identification of an UP-regulated gene encoding A protein related to ubiquitin conjugating enzyme." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268862.
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Silva, Jefferson José Soares da. "Ligação de hidrogênio intermolecular entre o benzeno e as espécies doadoras de próton: HF, HCl, HCN, H2O, NH3, CH4 E C2H6." Universidade Federal da Paraíba, 2015. http://tede.biblioteca.ufpb.br:8080/handle/tede/8208.
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This work deals with the computational quantum study of structural, electronic , vibrational and topological properties of hydrogen complexes C6H6•••HX , with proton, donor species , HF , HCl , H2O , HCN , NH3 , CH4 and C2H6 , interacting with a region of high electron density of the type π present in benzene. The computational methods of electronic structure Density Functional Theory with Hybrid functional B3LYP and PBE1PBE and Perturbative Theory of Many Bodies of order 2 were employed, all with the Pople basis set 6-311 ++ G ( d, p ) . The values of hydrogen bonding energy were submitted to Basis set superposition error and Vibrational Zero Point Energy corrections. The complexes of hydrogen HF, HCl, HCN, H2O and NH3 showed increments in H-X bond length, while CH4 and C2H6 have presented a shortening, H-C bond length due to formation of the intermolecular bond. The corrected intermolecular energy values follow the reverse trend of the values obtained for the increase, in H-X bond length. With the exception of ethane, all redshift values are positive, with higher values when the symmetry was not fixed. The employment of quantum theory of atoms in molecules shows the change in electron density of both interacting species, and in addition the density values are small and the density of the Laplacian are positive. The methods followed the same trend for the properties of interest, suggesting the use of calculations via density functional theory due to lower computational requirements, to study such systems.
Este trabalho trata do estudo quântico computacional de propriedades estruturais, eletrônicas, vibracionais e topológicas dos complexos de hidrogênio C6H6•••H-X, com as espécies doadoras de próton, HF, HCl, H2O, HCN, NH3, CH4 e C2H6, interagindo com uma região de alta densidade eletrônica do tipo π presente no benzeno. Os métodos computacionais de estrutura eletrônica empregados foram a Teoria do Funcional da Densidade com os funcionais híbridos B3LYP e PBE1PBE e a Teoria Perturbativa de Muitos Corpos de ordem 2, todos com o conjunto de base de Pople 6-311++G(d,p). Os valores da energia da ligação de hidrogênio sofreram correções do Erro de Superposição do Conjunto de Funções de Base e da Energia Vibracional do Ponto Zero. Os complexos de hidrogênio com HF, HCl, HCN, H2O e NH3 apresentaram incrementos no comprimento da ligação H-X, enquanto o CH4 e o C2H6 chegaram a apresentar encurtamento do comprimento de ligação H-C, devido a formação da ligação intermolecular. Os valores de energia intermolecular corrigida seguem a tendência inversa dos valores obtidos para o incremento do comprimento de ligação H-X. Com exceção do etano, todos os valores redshift são positivos, apresentando valores mais elevados quando a simetria não foi fixada. O emprego da teoria quântica de átomos em moléculas evidencia a mudança na densidade eletrônica de ambas as espécies interagentes, e, além disso os valores da densidade são pequenos e do laplaciano da densidade são positivos. Os métodos empregados seguiram a mesma tendência para as propriedades de interesse, sugerindo o uso de cálculos via teoria do funcional da densidade, devido a menor demanda computacional, para estudar sistemas desse tipo.
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Yun, Tae-Jung. "Using ubiquitous communication technology to improve pediatric asthma management." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/44794.
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Information and communication technologies (ICTs) for chronic care are increasingly being researched in Human-Computer Interaction. One of the current health management areas where ICTs have been employed is in supporting communications between patients and physicians. This is particularly relevant for patients suffering from chronic diseases since there is evidence that better communication leads to better health outcomes.
Researchers are investigating different chronic diseases to design and test technology interventions to promote better chronic disease care. However, few have investigated pediatric asthma as a case study for designing communication technologies. The World Health Organization (WHO) estimated in 2008 that 300 million people suffer from asthma, and that asthma is the most common chronic illness among children. Asthma interferes with breathing by preventing airflow into the lungs. It is difficult to determine the actual cause of asthma and to predict who will have asthma. These unique challenges provide opportunities to investigate pediatric asthma management.
To address these challenges, I have conducted a series of studies with pediatric asthma patients, families, and healthcare providers to better understand their needs, challenges and strategies regarding the use of technologies. I have conducted interviews, a focus group, and a technology probe study to create and refine initial technology designs for children with asthma and their caregivers. Based on the Health Belief Model (HBM), patient-provider communications, and my findings in the prior studies, I designed a mobile and web service to increase asthma knowledge and symptom/management awareness in the child for better health outcomes, and to affect the perceived quality of interaction with healthcare providers.
I show the results of my two field deployment studies with total 65 patients to learn how the system affected their practices and health outcomes. My contributions come from an increased understanding in three areas: physician-patient communication via a mobile and web services; ubiquitous communication technology designs to improve current pediatric asthma practices; and controlled evaluation of a ubiquitous communication technology, SMS, in the field.
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Livedalen, Rachel Lynn. "Hey! Hey! What ever happened to the garden?" Thesis, University of Iowa, 2014. https://ir.uiowa.edu/etd/4680.
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Femininity, in its normative socially driven state, is not a natural trait but a ghost that bears its past incarnations. I am interested in gender as a haunting social apparatus. Gender roles and representations have shifted throughout history, yet remain firmly attached to their antecedents. My creative research focuses on femininity as set forth in religion, social practices, and cultural phenomena and how these forces intersect at the present moment to create a complicated relationship of gender identity and expectations.
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Domiňáková, Michaela. "Architektura hry." Master's thesis, Vysoké učení technické v Brně. Fakulta architektury, 2020. http://www.nusl.cz/ntk/nusl-432920.
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Thesis use principles of play to reconstruct school building realized in the second half of the 20th Century. More broadly it deals with current state and conditions for reconstruction of modernist school buildings in Slovakia. According to Huizinga, play as such is older than culture and was a factor that stimulated the creation of culture and assumed the formation of human society. Free play is an instinct, a fundamental right, inherent in children, and a developed mechanism for acquiring skills and promoting learning. In the early 20th century, in a context marked by the horrors of war and the experience of the wild industrialization of the 19th century, society began to focus on the rights and education of children. This change in approach to childhood and children in general has been transcribed into theoretical and practical forms of architecture, from the scale of urbanism to the scale of an element of public space or domestic space. The concept of play began to penetrate into forms of education. In connection with urban transformation and housing construction playground have been created, which function should be the one of an institutionalized space education, but also of security or control. The same principles of control were also included in the architecture of other institutions such as schools. Project understands reconstruction of the school building not only as its annex or aesthetization but rather as reconfiguration and reinterpretation of its former principles.
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Skálová, Alena. "Opakované hry." Master's thesis, Vysoká škola ekonomická v Praze, 2007. http://www.nusl.cz/ntk/nusl-1669.
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Diplomová práce se snaží poskytnout ucelený pohled na známé poznatky z oblasti teorie opakovaných jako části teorie her. Teoretická část se zabývá předpoklady, výpočetními principy a rovnovážnými strategiemi pro opakované hry. V praktické části je teorie aplikována na oblast petrochemického průmyslu, konkrétně na konkurenci dvou čerpacích stanic v rámci prostorově vymezeného trhu.
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Tichá, Michaela. "Vícekriteriální hry." Doctoral thesis, Vysoká škola ekonomická v Praze, 2015. http://www.nusl.cz/ntk/nusl-261930.
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Theory of multicriteria games is a special field of game theory, when one or more players have at least two payoff functions and want to maximize simultaneously. The work introduces a number of new findings. It examined the concept of finding equilibria in pure strategies in noncooperative multicriteria game. It is possible to find all the equilibria in pure strategies by full search and solving two linear programs for each point. Furthermore, two linear programs are formulated for verifying that a selected point is the equilibrium of the game or not. In the noncooperative games is also introduced the concept that with knowledge of the equilibrium of bimatrix game determines preferences of the players. Although finding the equilibrium point of the bimatrix game is nonlinear problem, finding the preferences is linear problem. The latest findings in the noncooperative games is a generalization of the concept that solves multicriteria game by assigning weights to each criterion of each player. The work demonstrates that it may not be necessarily linear weights, but it can be more general function that describes the player's preference. The remaining part is devoted to knowledge in cooperative games. There is considered that the players know their preferences and are able to express them by weights. The game with known preferences is defined and solved with the use of bargaining theory. Then it is generalized to a case where players have more payoff functions, from which they can choose. Finally, the multicriteria case of voting game is defined. It is designed completely new concept, which selects the winning coalition in the voting game. This concept is then applied to the real situation after the elections to the Chamber of Deputies in 2013.
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Dillon, Andrew. "HCI Hypermedia." London: Taylor and Francis, 2001. http://hdl.handle.net/10150/106310.
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This item is not the definitive copy. Please use the following citation when referencing this material: Dillon, A. (2001) Usability Issues in Hypermedia. In: W. Karwowski (ed). Encyclopedia of Human Factors and Ergonomics. London: Taylor and Francis.
1. Introduction:
Hypermedia is a general term used to describe the presentation of graphical, textual, audio and video information in nodes (chunks) that can be linked together and accessed in a manner determined by the immediate interests of the user. Originating as an idea for mechanized information access and organization that better reflected the natural workings of the human mind by Vannevar Bush (1945), the potential of the computer to provide the best means of supporting hypermedia was recognized early on by thinkers such as Ted Nelson and Doug Engelbart (for a historical overview see Conklin, 1987). The move toward hypermedia-based digital documents holds with it the promise of user-controlled, immediate access to the world of published information and stored data. While originally a specialist application domain, in the last few years the World Wide Web has brought to everyoneâ s desktop the power and problems of hypermedia interaction. Yet from the outset, human factors researchers have noted a range of user issues that prevent the simple transition from analog to digital resources
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Freshley, Megan Elizabeth. "Hey Mammal." PDXScholar, 2014. https://pdxscholar.library.pdx.edu/open_access_etds/1784.
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This collection of poems is representative of the creative writing and literary studies completed during my time in Portland State University's Master of Fine Arts Program. Poetry workshops, seminars in prosody, syntax, and translation, and forays into the magic of rhetoric and defamiliarization in the novel have all contributed to the thinking and feeling shown in this work. Some themes that the collection circles around are: the alienating and sometimes ecstatic relationship between the identities of civilized human and human-as-animal, the processes of falling in and out of faith in a greater power and with belonging to a human community, non-binary and unconventional performances of gender and sexuality, psychological inquiry about the nature of the self, the cleaving of mind and body, and meditations on 21st Century youth.
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Tuutijärvi, M. T. (Miro-Tommi). "HCT-ajoneuvoyhdistelmän rengasseuranta ja rengastuksen vaikutus HCT-ajoneuvoyhdistelmän stabiliteettiin." Master's thesis, University of Oulu, 2017. http://urn.fi/URN:NBN:fi:oulu-201703161375.
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Tutkimuksessa selvitettiin tutkittavan HCT-ajoneuvoyhdistelmän rengastuksen ja renkaiden kulumisen vaikutusta ajostabiliteettiin. Tutkittava ajoneuvoyhdistelmä on vetoauton, puoliperävaunun ja täysperävaunun yhdistelmä, jonka kokonaispituus on noin 33 metriä ja suurin sallittu kokonaismassa 104 tonnia. Työssä määritettiin simulointimalli tutkittavasta ajoneuvoyhdistelmästä monikappaledynamiikka -ohjelmistolla ja rengasmallit ympärivuotisille sekä talvirenkaille kuivalle asfaltille, märällä asfaltille ja jääpinnalle. Tutkittavaan ajoneuvoyhdistelmään rakennetun ajotilasuureita mittaavan mittausjärjestelmän avulla määritettiin simulointimallin vastaavuus tutkittavaan ajoneuvoyhdistelmään ajokokeilla. Simulointimallilla tarkasteltiin teoreettisesti rengastuksen vaikutusta tutkittavan ajoneuvoyhdistelmän stabiliteettiin. Tutkittavasta ajoneuvoyhdistelmästä määritettiin simulointimalli monikappaledynamiikka -ohjelmistolla. Ajoneuvoyksiköiden rungot ja kuormat mallinnettiin jäykkinä keskitetyn massan kappaleina. Akselien tuenta ja jousitusjärjestelmä mallinnettiin mittauksiin tukeutuen. Rengasmallit määritettiin mittaamalla renkaiden voimantuotto kokeellisin mittauksin. Simulointimallin korrelaatio kokeellisiin mittauksiin oli verraten korkea. Ajoneuvoyhdistelmän stabiliteettiin vaikuttavat mm. ajonopeus, ajoneuvoyhdistelmän rakenneparametrit, ajoneuvoyhdistelmän tyyppi, ajoneuvoyksiköiden lukumäärä, ajoneuvoyhdistelmän mitoitus sekä ajoneuvoyhdistelmän rengastus. Ajoneuvoyhdistelmän sivuttaisvärähtelyt alkavat yleisesti ulkoisten herätteiden tai ohjausherätteen vaikutuksesta. Ulkoisia herätteitä ovat esimerkiksi sivuttaiset tuulenpuuskat ja erinäiset tieherätteet. Ajoneuvoyhdistelmän stabiliteetti on varsinkin kohtalaisen kitkan olosuhteissa yleensä riittävän hyvä ulkoisia herätteitä vastaan. Ohjausheräte on kuitenkin ongelmallisempi, sillä tieliikenteessä käytettävillä nopeuksilla vetoauton liikkeet vahvistuvat sitä seuraavissa perävaunuissa. Tällöin esimerkiksi nopea väistöliike voi johtaa ajoneuvoyhdistelmän stabiliteetin menettämiseen, joka voi ilmetä esimerkiksi perävaunun suurena sivuttaissuuntaisena heilahteluna matalan kitkan olosuhteissa tai perävaunun kaatumisena korkean kitkan olosuhteissa. Tutkitun ajoneuvoyhdistelmän stabiliteetti vaikuttaa haasteelliselta johtuen vetoauton sivuttaisliikkeiden suuresta vahvistumisesta täysperävaunussa. Ajoneuvoyhdistelmän kuljettajan on oltava tietoinen ajoneuvoyhdistelmän ominaisuuksista ja huomiota on kiinnitettävä erityisesti ennakoivaan ajotapaan äkkinäisten ohjausliikkeiden ehkäisemiseksi. Ajoneuvoyhdistelmän stabiliteettia voidaan parantaa matalan kitkan olosuhteissa huomattavasti talvirenkailla verrattuna ympärivuotisiin renkaisiin. Matalan kitkan olosuhteissa renkaiden kuluminen kasvattaa perävaunujen heilahtelua huomattavasti ja madaltaa nopeutta, jolla perävaunu voi ajautua ulos tieltä. Ajoneuvoyhdistelmän stabiliteetin kannalta edullisinta on pyrkiä asentamaan uudet ja olosuhteisiin sopivat renkaat ensisijaisesti täysperävaunun takatelille, jos koko ajoneuvoyhdistelmän rengastaminen olosuhteisiin sopivilla renkailla ei ole mahdollistaIn this study, the effect of tires and tire wear on the stability of a HCT vehicle combination is investigated. The studied vehicle combination consists of a tractor, semitrailer and a full trailer and the total length is about 33 meters and the gross combination weight is 104 tons. A simulation model of the studied vehicle is defined with a multi-body dynamics software and the tire models are defined for all-season and winter tires for dry asphalt, wet asphalt and ice. The studied vehicle combination is equipped with instrumentation to measure values concerning the driving dynamics and with the instrumentation the correlations between the simulation model output and measured values are defined. The simulation model is used to investigate the effect of tires on the stability of the studied vehicle combination. A simulation model of the studied vehicle is defined with multi-body dynamics software. The frames and the loads of the vehicle units are defined as rigid bodies with lumped masses. The axles and the suspension systems are defined based on the measurements of the studied vehicle combination. Tire models are defined based on the experimental measurements of the tire force output. The correlation between the simulation model output and the measured values was comparatively high. Driving speed, structural parameters, the type of the vehicle combination, the number of the vehicle units, the dimensioning of the vehicle combination and tires amongst other things affect the stability of a vehicle combination. The lateral oscillations of a vehicle combination usually originate from external forces or the steering input. External forces include, but are not limited to different road excitations and lateral gusts of wind. The stability of a vehicle combination, especially on high friction conditions, is usually adequate against external forces. Steering input is more problematic, because on the speeds used in the roads the lateral movements of the towing vehicle are amplified in the following vehicle units. This can cause the loss of stability when i.e. an obstacle has to be avoided which can result in huge trailer swing at low friction conditions or in a rollover of the trailer in high friction conditions. The stability of the studied vehicle combination is problematic, since the lateral movements of the towing vehicle are highly amplified on the full trailer. The driver has to be aware about the behavior of the vehicle combination and attention has to be paid to proactive driving style in order to prevent hazardous steering inputs. The stability of the vehicle combination can be improved significantly with winter tires on low friction conditions when compared with all-season tires. In the low friction conditions the tire wear increases trailer swing notably and lowers the speed when the trailer might drift off the road. Regarding the stability of the vehicle combination, installing the new and right tires for the conditions on the rear bogie of the full trailer is desirable, if changing all the tires is not possible
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Landinez, Borda Edgar Josué 1984. "Mechanical properties of HCP 4He = Propriedades mecânicas de 4He HCP." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/276927.
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Orientador: Maurice de KoningTese (doutorado) - Universidade Estadual de Campinas, Instituto de Física Gleb Wataghin
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Resumo: Esta Tese aborda o problema de determinar propriedades mecânicas fundamentais de 4 He solido na fase hcp usando simulação atomística. Tais propriedades têm sido associadas à possível existência de uma fase cristalina superfluida conhecida como super-solidez. Embora experimentos sofisticados investigando propriedades mecânicas do Hélio sólido têm sido realizados, os resultados dependem da dinâmica microscópica que nem sempre é acessível experimentalmente. Desta maneira as interpretações dos experimentos ficam sujeitos a debates. Neste contexto a modelagem atomística é uma ferramenta útil para fornecer informação qualitativa e quantitativa do comportamento atomístico das propriedades mecânicas. Através de Monte Carlo de integrais de trajetória (PIMC) calculamos a resistência ideal de cisalhamento e tensão de Peierls de uma discordância screw para este sólido quântico protótipo. A resistência ideal estabelece um limite teórico superior de comportamento elástico do material. É a máxima tensão que um cristal livre de defeitos pode suportar, sem produzir uma deformação plástica. Os reultados mostram que o limite de resistência ideal é acompanhado pela nucleação homogênea de uma falha de empilhamento. A resistência ideal é anisotrçopica no plano basal, mas esta anísotropia é bem descrita pela lei de Schmid, que é baseida em conceitos clássicos. Além disso, a comparação do valor da resistência ideal com os de um conjunto grande de cristais clássicos mostra que os resultados para 4 H e estão bem descritos pelo modelo Frenkel-Orowan modificado, que também se baiseia em conceitos puramente clássicos. Em relação às propierdades de discordância, investigamos a estrutura do caroço e a tensão de Peierls para a discordância screw no plano basal. Os resultados mostram uma forte tendência de dissociação e uma tensão de Peierls da ordem e 0.4 bar e estão totalmente consistentes com o comportamento em sólidos clássicos. Assim, os resultados da Tese mostram que, mesmo em regimes de temperatura onde a fase líquida é superfluida, o ordenamento cristalino parece suprimir os efeitos quânticos resposáveis pela super-fluidez no líquido.
Abstract: This Thesis addresses a number of issues related to the determination of the fundamental mechanical properties of hcp 4 He. These properties have been linked to the possible existence of a superfluid crystalline phase know as supersolid. While many sophisticated experiments have investigated these properties, their results often require assumptions regarding the underlying processes on the atomic scale which are not accessible experimentally. In this way, the experimental interpretations often remain subject of debate. In this context, atomistic modeling is a useful tool that allows one to obtain both qualitative as well quantitative information about these processes. Using Path-integral Monte Carlo simulations we compute the ideal shear strength (ISS), as well as the structure and mobility parameteres for the screw dislocation for this prototypical quantum solid. The ideal shear strength represents a theoretical upper limit of the elastic response of a crystal, being defined as the maximum stress a defect-free crystal can withstand before deforming plastically. Our resuls show that the ISS limit is accompanied by the homogeneous nucleation of a stacking fault. Furthermore, the ISS on the basal plane is found to be anisotropic, although the anisotropy is well described by Schmid¿s law of resolved shear stress. In addition, comparison of the intrinsic ISS value to values of a large set of classical crystals shows that the results for 4 He are well described by the modified Frenkel-Orowan model, which is also based on purely classical concepts. Considering dislocation properties, we investigate the core structure and Peierls stress for the screw dislocation in the basal plane. The results show a strong dissociation tendency of the core and a Peierls stress of the order of 0.4 bar, consistent with the behavior of classical solids. Accordingly the results of this Thesis show that, even in the temperature regime where the liquid phase is superfluid the crystalline order seems to suppress the quantum effects for the liquid superfluidity
Doutorado
Física
Doutor em Ciências
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Formánek, Václav. "Pravidla hry: kritické hry a teorie na poli mezinárodních vztahů." Master's thesis, Vysoká škola ekonomická v Praze, 2010. http://www.nusl.cz/ntk/nusl-198822.
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The main goal od critical theories of international relations is to help to achieve more universal freedom and equality in the world. Critical theorists use different kinds of strategies to achieve this goal. Persuasive popularization by critical videogames is one those strategies. Author analyzes different strategies of such persuasion. He also designs own concept of critical game. The goal of this game is to present main ideas of critical theories to the general public in the most precise but still understandable way. Autor wants to show the potential of videogames for popularization of critical theories.
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Zhdanovich, Anton. "Evropská specifika umění hry na bicí nástroje: Základy přirozené hry." Master's thesis, Akademie múzických umění v Praze.Hudební a taneční fakulta. Knihovna, 2017. http://www.nusl.cz/ntk/nusl-363571.
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This work is a summary of the information and knowledge about the basics that make up the present tradition of playing percussion instruments in Europe (predominantly Western). Its main purpose is to support the development of percussion instruments in Czech Republic, especially in schools, where the playing level is in the development stage and needs to be supported from other sources. During my Master's study at HAMU (2014-2017), I took part in many of international events in this field, which were focused on the development of young musicians of my generation on musical, technical, mental and aesthetic side. The obtained information by feedbacks and comments from leading teachers and performers in the field is the absolute basis for this work. Awareness of the principles and basics that will be written here requires a presence of certain musical and life experiences, so this work is intended for the age category from the students of secondary vocational schools and above.
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Hanuš, Michal. "Technika varhanní hry." Master's thesis, Akademie múzických umění v Praze. Hudební fakulta AMU. Knihovna, 2009. http://www.nusl.cz/ntk/nusl-79086.
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The thesis named The technique of the organ playing is focused on the main elements of the organ interpretation - the technique, the generation of the tone sound and on the application of these elements. Next points: 1. hindsight, to 19th century - the era of the grounding of the Prague organ school, 2.the opinions of the organ sound, registration and organ building. The organ sound, the registration and organ building have (after opinion of the author) big influence on the interpretation and taste. Author finds the arguments for his ideas in specialized publications and instructive materials, mainly of 19th and 20th centuries. He develops his view about generation of the sound on different types of instruments , the cultivation of the sound and articulation influences markedly the sound of the organ. There is the way to the lively and pregnant interpretation.
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Pedraza, Jorge Hernando. "La CAN hoy." Universidad Peruana de Ciencias Aplicadas (UPC), 2021. http://hdl.handle.net/10757/657017.
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Jorge Hernando Pedraza.
Abogado de la Universidad Externado de Colombia con postgrado en Gestión de Entidades Territoriales y estudios de Diplomacia y Relaciones internacionales. Actualmente Secretario General de la Comunidad AndinaHoy la Comunidad Andina, integrada por Bolivia, Colombia, Ecuador y Perú, se ha convertido en el organismo más sólido de integración del continente, con una zona de libre comercio, normas supranacionales en diversos ámbitos de acción, derechos ciudadanos como el que permite viajar sin visa ni pasaporte por los cuatro países y otras recientemente aprobadas como la norma que elimina los costos de roaming internacional, el Estatuto Migratorio Andino, la Carta Ambiental Andina, el Observatorio del Mercurio, la decisión que promueve el empoderamiento de la mujer.
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Ilyina, Tatjana P. "The fate of persistent organic pollutants in the North Sea multiple year model simulations of {[gamma]-HCH [gamma-HCH], {[alpha]-HCH [alpha-HCH] and PCB 153." Berlin Heidelberg New York Springer, 2006. http://deposit.d-nb.de/cgi-bin/dokserv?id=2874201&prov=M&dok_var=1&dok_ext=htm.
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Carcabal, Pierre. "Etude par spectroscopie infrarouge des complexes C2H2-HCl et C2H4-HCl." Phd thesis, Université Paris Sud - Paris XI, 2000. http://tel.archives-ouvertes.fr/tel-00009002.
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Les interactions intermoléculaires jouent un rôle important dans de nombreux processus tant dans le domaine de la physique que de la chimie. L'étude des systèmes de petite taille liés par ces interactions (complexes moléculaires) permet d'avoir des informations très précises à partir desquelles il est possible d'aller plus avant dans la compréhension des processus qui résultent des ces interactions (prédissociation, changement de structure des entités du complexe). Pour étudier expérimentalement les complexes moléculaires de petite taille, nous avons élaboré un dispositif combinant un jet moléculaire pulsé à fente et une diode laser accordable dans l'infrarouge. Ce dispositif nous a permis d'observer les spectres d'absorption infrarouges de complexes à basse température (10 K) et à haute résolution (5.10-3 cm-1) avec une grande sensibilité grâce au système de détection synchrone hétérodyne que nous utilisons. Nous avons observé les spectres du mode d'élongation H-Cl des complexes C2H2-HCl et C2H4-HCl. Les résultats expérimentaux que nous ont fournis l'analyse spectroscopique rovibrationnelle des ces vibrations intramoléculaires ont permis de remonter à des informations sur les interactions mises en jeu dans ces complexes (influence de l'excitation vibrationnelle sur l'interaction, estimation de l'énergie de liaison à partir d'un modèle pseudo-diatomique). Afin d'avoir une vision plus globale des systèmes étudiés, nous avons complétés notre étude expérimentale par des études de chimie quantique. Nous avons notament dépassé les approximations usuelles des calculs ab initio par un calcul du potentiel intermoléculaire sur une grille à deux dimensions. Nous avons ainsi pu obtenir des informations sur les effets d'anharmonicité, de la correction de l'erruer de superposition de base et de couplages entre les mouvements intramoléculaires et intermoléculaires.
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Li, Dongsheng. "The role of HCV core protein in the regulation of HCV replication /." St. Lucia, Qld, 2003. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18009.pdf.
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Uribe, Gabriela. "Hey Neighbor! Let's play." Research Showcase @ CMU, 2012. http://repository.cmu.edu/theses/28.
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“Hey Neighbor! Let’s Play.” Is a masters thesis evaluating the effects games and playful interactions have in building a sense of community. Throughout the thesis, I researched the emotional connections urban residents have with their communities and neighbors, and used the research data to develop installations for play throughout pedestrian staircases in the Southside Slopes, an urban neighborhood in Pittsburgh. From these installations, I collected user feedback and evaluated how the games affected various residents of the community. From the feedback, I was able to ultimately establish several design principles to inspire and facilitate future designers interested in designing neighborhood-based games.
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Maurer, Max-Emanuel. "Counteracting phishing through HCI." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-169668.
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Computer security is a very technical topic that is in many cases hard to grasp for the average user. Especially when using the Internet, the biggest network connecting computers globally together, security and safety are important. In many cases they can be achieved without the user's active participation: securely storing user and customer data on Internet servers is the task of the respective company or service provider, but there are also a lot of cases where the user is involved in the security process, especially when he or she is intentionally attacked. Socially engineered phishing attacks are such a security issue were users are directly attacked to reveal private data and credentials to an unauthorized attacker. These types of attacks are the main focus of the research presented within my thesis.
I have a look at how these attacks can be counteracted by detecting them in the first place but also by mediating these detection results to the user. In prior research and development these two areas have most often been regarded separately, and new security measures were developed without taking the final step of interacting with the user into account. This interaction mainly means presenting the detection results and receiving final decisions from the user. As an overarching goal within this thesis I look at these two aspects united, stating the overall protection as the sum of detection and "user intervention".
Within nine different research projects about phishing protection this thesis gives answers to ten different research questions in the areas of creating new phishing detectors (phishing detection) and providing usable user feedback for such systems (user intervention): The ten research questions cover five different topics in both areas from the definition of the respective topic over ways how to measure and enhance the areas to finally reasoning about what is making sense. The research questions have been chosen to cover the range of both areas and the interplay between them. They are mostly answered by developing and evaluating different prototypes built within the projects that cover a range of human-centered detection properties and evaluate how well these are suited for phishing detection. I also take a look at different possibilities for user intervention (e.g. how should a warning look like? should it be blocking or non-blocking or perhaps even something else?). As a major contribution I finally present a model that combines phishing detection and user intervention and propose development and evaluation recommendations for similar systems. The research results show that when developing security detectors that yield results being relevant for end users such a detector can only be successful in case the final user feedback already has been taken into account during the development process.Sicherheit rund um den Computer ist ein, für den durchschnittlichen Benutzer schwer zu verstehendes Thema. Besonders, wenn sich die Benutzer im Internet - dem größten Netzwerk unserer Zeit - bewegen, ist die technische und persönliche Sicherheit der Benutzer extrem wichtig. In vielen Fällen kann diese ohne das Zutun des Benutzers erreicht werden. Datensicherheit auf Servern zu garantieren obliegt den Dienstanbietern, ohne dass eine aktive Mithilfe des Benutzers notwendig ist. Es gibt allerdings auch viele Fälle, bei denen der Benutzer Teil des Sicherheitsprozesses ist, besonders dann, wenn er selbst ein Opfer von Attacken wird. Phishing Attacken sind dabei ein besonders wichtiges Beispiel, bei dem Angreifer versuchen durch soziale Manipulation an private Daten des Nutzers zu gelangen. Diese Art der Angriffe stehen im Fokus meiner vorliegenden Arbeit. Dabei werfe ich einen Blick darauf, wie solchen Attacken entgegen gewirkt werden kann, indem man sie nicht nur aufspürt, sondern auch das Ergebnis des Erkennungsprozesses dem Benutzer vermittelt. Die bisherige Forschung und Entwicklung betrachtete diese beiden Bereiche meistens getrennt. Dabei wurden Sicherheitsmechanismen entwickelt, ohne den finalen Schritt der Präsentation zum Benutzer hin einzubeziehen. Dies bezieht sich hauptsächlich auf die Präsentation der Ergebnisse um dann den Benutzer eine ordnungsgemäße Entscheidung treffen zu lassen. Als übergreifendes Ziel dieser Arbeit betrachte ich diese beiden Aspekte zusammen und postuliere, dass Benutzerschutz die Summe aus Problemdetektion und Benutzerintervention' ("user intervention") ist. Mit Hilfe von neun verschiedenen Forschungsprojekten über Phishingschutz beantworte ich in dieser Arbeit zehn Forschungsfragen über die Erstellung von Detektoren ("phishing detection") und das Bereitstellen benutzbaren Feedbacks für solche Systeme ("user intervention"). Die zehn verschiedenen Forschungsfragen decken dabei jeweils fünf verschiedene Bereiche ab. Diese Bereiche erstrecken sich von der Definition des entsprechenden Themas über Messmethoden und Verbesserungsmöglichkeiten bis hin zu Überlegungen über das Kosten-Nutzen-Verhältnis. Dabei wurden die Forschungsfragen so gewählt, dass sie die beiden Bereiche breit abdecken und auf die Abhängigkeiten zwischen beiden Bereichen eingegangen werden kann. Die Forschungsfragen werden hauptsächlich durch das Schaffen verschiedener Prototypen innerhalb der verschiedenen Projekte beantwortet um so einen großen Bereich benutzerzentrierter Erkennungsparameter abzudecken und auszuwerten wie gut diese für die Phishingerkennung geeignet sind. Außerdem habe ich mich mit den verschiedenen Möglichkeiten der Benutzerintervention befasst (z.B. Wie sollte eine Warnung aussehen? Sollte sie Benutzerinteraktion blockieren oder nicht?). Ein weiterer Hauptbeitrag ist schlussendlich die Präsentation eines Modells, dass die Entwicklung von Phishingerkennung und Benutzerinteraktionsmaßnahmen zusammenführt und anhand dessen dann Entwicklungs- und Analyseempfehlungen für ähnliche Systeme gegeben werden. Die Forschungsergebnisse zeigen, dass Detektoren im Rahmen von Computersicherheitsproblemen die eine Rolle für den Endnutzer spielen nur dann erfolgreich entwickelt werden können, wenn das endgültige Benutzerfeedback bereits in den Entwicklungsprozesses des Detektors einfließt.
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Durant, Caballero Clelia. "Turismo doméstico oportunidad hoy." Trabajo aplicativo final, Universidad Peruana de Ciencias Aplicadas - UPC. Escuela de Postgrado, 2014. http://hdl.handle.net/10757/311194.
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En el 2011, Lima reportó el 84% del total de viajes nacionales, constituyéndose en el principal emisor de vacacionistas a nivel nacional, con 3,120 millones de viajes, razón que explica la decisión de trabajar únicamente con este segmento de viajeros. El presente trabajo tiene como objetivo central desarrollar una propuesta orientada a los tour operadores, agencias de viaje y viajeros limeños, en la que se presenten recomendaciones destinadas a promover el uso de paquetes turísticos.
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Berríos, Fuentes Alvaro, Ortiz Arantza Carrizo, Pascual Emilio Díaz, Vargas José Miguel Peña, Bustos Gabriela Rojas, and Salazar Karina Saldivia. "No hay muerto malo." Tesis, Universidad de Chile, 2016. http://repositorio.uchile.cl/handle/2250/139991.
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Cortometraje de EgresoEduardo es un jubilado poco sociable, molestado constantemente por Roberto: su insoportable vecino de enfrente, quien además tiene a Jesús, un perro que se defeca diariamente en su patio. Un día Eduardo no aguanta más y decide encarar a su vecino, sin embargo, las cosas salen mal: Roberto no estaba en su casa y, sin querer, termina provocando el atropello de Jesús. Eduardo, desconcertado por el accidente, no halla nada mejor que ocultar el cuerpo del perro dentro de su casa. Con el pasar de los días, la idea de de que Roberto se entere de lo ocurrido, comienza a agobiarlo cada vez más. Todo empeora cuando Eliana, su tímida vecina de al lado, lo descubre y en vez de acusarlo, lo chantajea y obliga a fingir ser su pareja frente a la gente del barrio. Cuando Eduardo ya no soporta más, toma el cuerpo de Jesús y sale exaltado a la calle con la intención de entregárselo a Roberto, pero un auto pasa y lo atropella. Al verlo muerto con el perro en sus brazos, los vecinos que antes lo despreciaban, ahora lo llaman héroe.
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Trazegnies, Granda Fernando de. "¿Hay un "Derecho" prehispánico?" IUS ET VERITAS, 2016. http://repositorio.pucp.edu.pe/index/handle/123456789/123341.
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Rochabrún, Silva Guillermo. "¿Hay una metodología marxista?" Pontificia Universidad Católica del Perú, 2013. http://repositorio.pucp.edu.pe/index/handle/123456789/115394.
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El presente artículo es la reformulación de una clase del curso Temas de Economía Política ofrecida el 23 de Octubre de 1974. El contenido ha sido completamente modificado en su forma, conservando en algunos momentos su carácter hablado. Salvo algunas alusiones,toda la exposición se limita a la 1ra. Sección del Volúmen 1 de "El Capital" y asume que el lector la ha estudiado. La relación original publicada en Diciembre de 1974 ha sido íntegramente corregida y modificada en algunos puntos centrales.
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Ferrero, Rebagliati Raúl. "La soberanía marítima hoy." Pontificia Universidad Católica del Perú, 2013. http://repositorio.pucp.edu.pe/index/handle/123456789/116111.
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Svoboda, Lukáš. "Metodika hry na fagot." Master's thesis, Akademie múzických umění v Praze. Hudební fakulta AMU. Knihovna, 2011. http://www.nusl.cz/ntk/nusl-96731.
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This thesis deals with the methodology playing the bassoon in the form and rules of School Education. The School Education Program for Elementary schools of art will replace the previously existing curriculum and will determine the compulsory teaching plan for the next years.
Firstly, I present the final version of The School Education Plan for Štefánikova Elementary school of art, which has the shape of a table and which is formally accurate. After that follows the Basic text of The School Education Program which includes more text and more options of the concept of teaching. The longest, methodical part of the work, where I describe various technical terms and important concepts, is based on the Basic text of the School Education Program.
The aim is to allow insight into the creation of the School Education Program and to clarify the meaning of terms.
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Ушеніна, Л. О., Л. Ю. Сиянова, and О. В. Рябоконь. "Епідеміологічні особливості HCV-інфекції." Thesis, Вид-во СумДУ, 2006. http://essuir.sumdu.edu.ua/handle/123456789/13674.
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Vávrová, Katka. "Marketingové využití hry geocaching." Master's thesis, Vysoká škola ekonomická v Praze, 2011. http://www.nusl.cz/ntk/nusl-125153.
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This diploma thesis deals with analysis of use of the game geocaching. The aim of this work is to explain whether and under what conditions it is possible to use geocaching in marketing activities. There is an analysis and evaluation of existing projects using geocaching. Own project is designed pursuant the obtained results.
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Horáková, Monika. "Gamifikace a sociální hry." Master's thesis, Vysoká škola ekonomická v Praze, 2011. http://www.nusl.cz/ntk/nusl-165133.
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This thesis is focused on gamification and practical testing in internal training of new-hired employees. The main objective was to introduce gamification as a term and show how gamification can help with internal training of new-hired employees. In the theoretical part games and their meanings are defined. Then it is necessary to describe gamification itself with historical evolution and used player types. To understand principles of gamification and player's motivation, game elements and mechanism are defined. Selected examples of gamification divided by fields of applications are at the end of the theoretical part. Practical part describes the gamification environment of tool New Hire Orientation made by MindTickle and practical application of testing at H1.cz. Conclusion contains results and suggested recommendations for H1.cz and for MindTickle.
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Ward, Scott Matthew. "Towards an HCV vaccine /." St. Lucia, Qld, 2001. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16402.pdf.
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Harper, John. "Oat Hay Variety Evaluation." College of Agriculture, University of Arizona (Tucson, AZ), 1987. http://hdl.handle.net/10150/203798.
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Mikyška, Tomáš. "Zvuková dramaturgie rozhlasové hry." Master's thesis, Akademie múzických umění v Praze.Hudební a taneční fakulta. Knihovna, 2013. http://www.nusl.cz/ntk/nusl-177792.
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This thesis is dealt with one of the most important domain in preparatory and production works of radio drama - sound dramaturgy. In the first part I systemize sound material from the point of view of creativity focusing on its formative and semantic potential. Then I apply the previous findings considering the radio drama production itself. I distinguish two phase of sound-dramaturge`s work: phase of timeline construction and phase of building up the sound scene. There are many practical examples illustrating my partial conclusions in the thesis as well as contemplations of next radio drama sound dramaturgy development. I suppose this thesis will be a contribution for radio drama theory in the Czech area.
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Krejbich, Tomáš. "Metodika hry na violu." Master's thesis, Akademie múzických umění v Praze.Hudební a taneční fakulta. Knihovna, 2016. http://www.nusl.cz/ntk/nusl-253935.
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As the title suggests, this diploma thesis is going to question the methods of the viola playing. The word methodology itself is quite a wide topic to discuss,
in the history of the books about music, this literature is very often dedicated to some analysis of the instrument as well as the player himself and their mutual connection and how to work on it. So these are usually overall technique tutorials and manuals given to improve the playing, full of images and pictures, which bring some promise of improvement if being followed word for word. Many books have been written by multiple writers, devoted to all sorts of instruments and each of them gave their imprint and if put altogether, they even might embrace the whole music player's capacity. The goal of the author here is not making another detailed methodology, focused on particular issues, he more wants to discuss the difference between the violin and the viola, since he has had the time to observe both in years and mainly he would like to share the knowledge obtained during his everyday studies, thus contribute or bring someting new to this world of methodology. The work is deeply focused on free-writing more than source-finding, therfore there are minimum of resources or links. It hopes to give help to the potential reader and same the author himself, as he would like to sort out his musical values.
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Kleefeld, Felix [Verfasser]. "Untersuchung des Einflusses einer Interferon-freien HCV-Eradikation auf neurokognitive Funktionen in HIV/HCV-koinfizierten und HCV-monoinfizierten Patienten / Felix Kleefeld." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2019. http://d-nb.info/1179778103/34.
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Eisner, Christopher W. "Predicting Incidences of HCV and Advanced-Stage HCV Outcomes from the Opioid Epidemic." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1595616293410679.
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Akil, Abdellah. "Susceptibilité génétique des variants EP300 et PCAF au carcinome hépatocellulaire et rôle de septine 9, PIAS1 et SUMO1 dans la réplication du virus de l'hépatite C." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA11T079/document.
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Le carcinome hépatocellulaire (CHC) est la tumeur maligne primitive du foie la plus fréquente (90 % des cas). Le CHC est le cinquième cancer par ordre de fréquence à l'échelon mondial, la troisième cause de décès par cancer dans le monde entier et son incidence est actuellement croissante. Parmi Les principaux facteurs prédictifs de survenue de CHC ; les altérations génétiques, l'alcool et les infections par les virus des hépatites B (VHB) et C (VHC). Les travaux de thèse en cotutelle menés entre l’Universités Paris Sud 11-France et l’Université Mohammed V- Rabat –MAROC ont porté essentiellement sur l’étude de deux facteurs de risque impliqués dans le développement du carcinome hépatocellulaire ; le polymorphisme génétique et l’infection par le virus de l’hépatite C. Dans un premier temps, ce travail de recherche s’est focalisée sur l’éventuelle relation pouvant liée les polymorphismes génétiques des gènes PCAF, P300 au carcinome hépatocellulaire. Sur le plan génétique nous avons constaté que les génotypes Val/Val de EP300 et Ser/Ser de PCAF apparaissent comme les plus associés à l’hépatocarcinome. Par ailleurs, ces derniers se trouvent associés d’une manière significative au carcinome hépatocellulaire. Par la suite, notre travail a consisté à mieux caractériser la variabilité génétique du HCV et l’épidémiologie des souches virales chez la population marocaine pour lesquelles peu de données étaient disponibles. Les analyses phylogénétiques des régions NS5B et E2 et les données épidémiologiques recueillies ont permis de répondre à ces questions. Enfin, La dernière partie des travaux de cette thèse vise à identifier des facteurs cellulaires essentiels à la réplication du VHC, dans l’objectif de définir de nouvelles cibles thérapeutiques pour le traitement des hépatites virales C. Nous avons pu identifier la septine 9 comme facteur cellulaire impliqué dans le cycle de vie virale du HCV, ainsi que les protéines PIAS1 et SUMO1 comme protéines régulatrices de la septine 9. De plus nous avons pu établir la relation entre ces protéines cellulaires dont la présence est nécessaire à la fois à la production des protéines virales ( CORE et E2) et à la réplication du virus dans la cellule hôteHepatocellular carcinoma (HCC) is the fifth most common cause of cancer worldwide and the third most common cause of cancer mortality. HCC is one of the few cancers with welldefined major risk factors. Major causes of HCC include hepatitis B, hepatitis C, alcoholic liver disease, nonalcoholic, steatohepatitis, hereditary hemochromatosis, and geneticalteration. The multifactorial causes of HCC might explain its complex molecular pathogenesis. Detailed understanding of epidemiologic factors and molecular mechanisms associated with HCC ultimately could improve our current concepts for screening and treatment of this disease. With a view toward current concepts for screening of this disease, first, we analyzed a genetic susceptibility to hepatocellular carcinoma. The aim of the current study was to assess the impact of the Ile997Val in EP300 and Asn386Ser in PCAF polymorphisms on the risk of HCC. we found that the Val/Val of the EP300 at codon 997 and Ser/Ser of the PCAF at codon 386 were associated with an increased risk of HCC in the Moroccan population. A higher risk of HCC was observed in HCV-negative subjects. We also found that male with Ser/Ser in thePCAF gene and women with Val/Val genotype of the EP300 had a higher risk to develop HCC. It appears that variants of the transcriptional coactivator genes (EP300 and PCAF) may influence HCC risk in populations with low mutations or hromosomal instability rates. Additional surveys are warranted to confirm this first report. The incidence of HCC is increasing in Western countries, mostly because of the high prevalence of hepatitis C virus (HCV) infection. In this sense, we have tried to identify new host factors involved in replication of HCV. Hepatitis C virus (HCV) replicates in the liver,and chronic infection often leads to cirrhosis, steatosis, and hepatocellular carcinoma. There is no vaccine to protect against HCV infection. Major improvement has been recently achieved regarding treatment of HCV infection however there is already evidence for emergence of resistance due to the high genetic variability of the HCV RNA genome. Thus it should be important, to design therapies which avoid genotypic resistance by targeting cellular proteins. Understanding the mechanisms that allow proper assembly and intracellular trafficking of HCV proteins may have a profound impact on the treatment efficacy. An important hallmark of chronic HCV infection is liver steatosis associated with the accumulation of lipid droplets (LDs). The LDs accumulated in the HCV infected cells and the HCV core protein induces the redistribution of LDs, through the clustering of these organelles in the perinuclear area, providing a platform for virus assembly and in the production of infectious particles. Several host proteins have been proposed to facilitate the replication of HCV however much is needed to elucidate the implicated mechanisms. Here we report that HCV infection increases expression and formation of septin 9 filament surrounding HCV core. Data of our study revealed the highest expression of septin 9 in samples from hepatocellular carcinoma (HCC) from patients with chronic HCV infection. Indeed, we brought newperception of septin 9 function regarding both microtubule and lipid structure organization. We proposed that HCV infection conducts to assembly of septin 9 in filaments through PIAS1. This may provide scaffolds to organize the microtubules network and LDs redistribution required for HCV assembly and replication. This study illuminates a new function of septin 9 in HCV life cycle through its association with lipids and microtubules. These events might depend on septin 9 SUMO1 modification by PIAS1. These findings also provide a step forwards in understanding the relationship between HCV and its host and open new therapeutic directions
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Burke, Stephanie. "Generalized Impairment of CD8+ T-cells in HCV Mono- and HIV-HCV Co-infection." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32770.
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Chronic hepatitis C virus (HCV) infection has global effects on the immune system. CD8+ T-cells, responsible for viral clearance and control, are dysfunctional for as yet unknown reasons. It is hypothesized that IL-7 signaling pathway deficiencies contribute to this impairment. Blood-derived CD8+ T-cells in chronic HCV mono- and HIV-HCV co-infection had lower IL-7-induced activation of STAT5 and production of Bcl-2, and lower proliferation in co-infection, compared to controls. Lower Bcl-2 production was also associated with increased fibrosis. These changes were independent of the IL-7 receptor α expression and suppressor of cytokine signaling 1 or 3 expression. Intrahepatic CD8+ T-cells in HCV-infection did not activate STAT5 above basal levels with cytokine stimulation and had lower Bcl-2 expression than blood-derived cells. In conclusion, bulk CD8+ T-cells were impaired in response to IL-7 and the IL-7 signaling pathway may be one mechanism by which CD8+ T-cells are impaired in chronic HCV infection.
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Tuthill, Tobias J. "Construction expression and preliminary biological analysis of HCV and HCV-dengue chimeric virus genomes." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368893.
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Reymann, Michael. "Ionenpaarbildung bei Multiphotonenanregung von HCl." Doctoral thesis, [S.l. : s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=965170861.
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Michel, Michael. "Prädissoziationsspektroskopie von HCl und DCl." [S.l. : s.n.], 2003. http://www.diss.fu-berlin.de/2003/150/index.html.
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Hughes, Hicks Lee. "Clínica de fertilidad padres hoy." Tesis, Universidad de Chile, 2015. http://repositorio.uchile.cl/handle/2250/137335.
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Tesis para optar al grado de Magíster en AdministraciónLee Hughes Hicks [Parte II] Análisis organizativo-financiero
De acuerdo a cifras de la ONG “Queremos Ser Padres” y el Ministerio de Salud la infertilidad afecta en Chile a más de 350 mil parejas, que corresponde aproximadamente a un 8 a un 11% de las parejas en edad reproductiva. De este importante número de parejas, sólo un porcentaje menor puede acceder a tratamientos de baja o alta complejidad. De acuerdo a información proveída por fuentes al interior de la industria de laboratorios farmacológicos en Chile se venden anualmente cerca de 28.000 tratamientos de Baja Fertilidad. La definición de infertilidad es “una enfermedad del Sistema Reproductivo definida como la incapacidad de lograr un embarazo clínico después de 12 meses o más de relaciones sexuales no protegidas”1. Actualmente el mercado de atención a parejas infértiles se concentra principalmente en 11 centros dedicados en Chile. El fuerte es de Alta Complejidad2, que es invasivo y de alto costo monetario (7 a 12 veces el costo de Baja Complejidad3). Varias razones explican la brecha restante de aproximadamente 90% que no accede a tratamiento. Una de ellas es que existe una limitada oferta por parte de los servicios médicos que entreguen estos tratamiento (Problema de Oferta), poca publicidad y desconocimiento de las parejas que existe solución para su infertilidad (Problemas de Demanda/Información) y, por último, estos tratamientos son de alto costo y tienen una muy baja cobertura de seguros estatal y una que está recién iniciándose desde las Isapres (Problemas de Financiamiento). “Clínica Padres Hoy” busca ampliar el mercado asociado a los ciclos de Baja Fertilidad a través de precios competitivos, una atención integral y tomar la amplia demanda de parejas en edad fértil de los grupos socioeconómicos C1 y C2. Además, se buscará alianzas con Isapres que, ya desde 2014, deben financiar parte de los costos de los tratamientos de baja Fertilidad a sus afiliados. Existe muy poca información al respecto y las Isapres han optado por no ampliar el conocimiento del público general. Por último, se buscará alianzas con centros médicos centrados en la alta complejidad. De esta forma, podrá existir derivación cruzada de pacientes, sinergías en servicios y descuentos. El tratamiento de Baja Complejidad puede tener hasta un 80% de eficacia si se comienza a tiempo, que se logra, normalmente, con dos ciclos por pareja. La tasa de éxito de los tratamientos de baja y alta complejidad se grafica en el Anexo III. Los tratamientos de Baja Complejidad se concentran en tres centros en Santiago y, además, son realizados a un bajo nivel por ginecólogos inexpertos. En Chile existen 1900 ginecólogos que cuentan con la certificación de la Sociedad de Ginecología como especialistas en la materia. La manera usual de proceder en casos de infertilidad es que ginécologos “de cabecera” sean quienes intenten proveer a sus pacientes el servicio para el cual no se encuentran correctamente capacitados. Quienes han recurrido a tratamiento de infertilidad consideran que este tiene una connotación negativa desde varias perspectivas4. A contar, desde una perspectiva personal, sienten que algo está mal con ellos mismos que son incapaces de engendrar vida, lo cual genera una presión social por lograr dar a luz a un niño/niña que se transforma en stress manifestado de diversas maneras; la experiencia es fría en términos del apoyo esperado como resultado del desarrollo de las relaciones humanas durante el proceso, sienten que los profesionales de la salud se imitan a prestar un servicio con cierto precio (en muchos casos bastante elevado) y existe una falencia importante en el acompañamiento de las personas durante el proceso de alta sensibilidad para ellos; los tratamientos de Baja Complejidad constituyen una pérdida de tiempo por lo que la única opción verdaderamente viable es la de Alta Complejidad. Lo anterior evidencia que existe una vacío en la información disponible y en el manejo del aspecto emocional asociados al período del tratamiento. Desde el punto de vista legal y cobertura del sistema de salud en Chile, el 17 de marzo de 2014 entró en vigencia la normativa que incorpora al Arancel de la Modalidad de Libre Elección de FONASA tratamientos de fertilización asistida de Baja Complejidad. Las prestaciones incluidas son las consultas de especialidad, exámenes de laboratorio e imagenología propios del tratamiento, procedimiento de criopreservación, capacitación espermática, inseminación artificial, fármacos e insumos requeridos para el tratamiento referido, previa indicación médica. La adición de la cobertura de estos tratamientos a sistemas Fonasa e Isapres representa una oportunidad de capturar un flujo existente (quienes tienen Isapre) y uno nuevo (quienes están en FONASA) de pacientes. La visión general de la compañía es entregar un acompañamiento integral a las parejas que sufren de infertilidad mientras se encuentran están pasando por el tratamiento. El énfasis y aspecto diferenciador de la Clínica será puesto en el acompañamiento de las parejas, en lugar del mero tratamiento de la enfermedad, lo cual esperamos sea gatillante en ser reconocidos como el mayor centro integral para estos efectos del país. El producto es el tratamiento en base a la entrega de las medicinas para estimular la producción de óvulos y su posterior desarrollo en el sistema reproductor femenino, el cual será ofrecido en tres formatos que van desde un plan básico que se acoge solamente a la prestación asociada a FONASA y dos planes que adicionan servicios de especialistas psicológicos, nutricionista, medicina complementaria y orientador familiar. El mercado potencial corresponde a 250.000 parejas infértiles en Chile que, actualmente, se ve reflejado en sólo 28.000 tratamientos basados en la aplicación de medicamentos e inseminación (excluye cirugías) al año. De este total el mercado objetivo de la Clínica Padres Hoy es 8.000 tratamientos que se llevan a cabo con el medicamento Gonadotropina, cuya valorización hoy alcanza los CLP $4.000.000.000 y ha crecido a tasas del 15% anualmente. El segmento objetivo es mujeres en edad fértil (26 a 43 años) de los estratos socioeconómicos C1 y C2. El servicio se entrega, de manera exclusiva, en las dependencias de la Clínica, incluyendo los medicamentos cuyas dosis deben ser autoadministradas por la paciente vía inyecciones. El marketing inicial del producto se realizará de forma masiva en radio y mediante la entrega de brochures y flyers de la Clínica, de manera de darla a conocer, pero el fuerte del crecimiento se basará en la recomendación de las pacientes. Se espera que el crecimiento sea fuerte, permitiendo alcanzar 20% de participación de mercado al año 3. La administración de la CPH (Clínica Padres Hoy) será realizada, primordialmente, por una matrona, quien es la principal figura en la entrega del servicio y en el quehacer diario. Los socios gestores serán Directores de las áreas de Administración Finanzas, Comercial, Médica y tendrán una participación activa tanto en los lineamientos como en la actividad dentro de la Clínica, al menos, al comienzo de la implementación de este proyecto. La estimación de inversión que se requerirá es de 489 millones de pesos. La mayor parte de estos fondos se utilizará para adquirir una máquina para realizar ecografías y un sistema CRM y altos gastos de marketing, en adición a la cobertura de las operaciones.
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Němcová, Lenka. "Netradiční výuka hry na housle." Master's thesis, Akademie múzických umění v Praze.Hudební a taneční fakulta. Knihovna, 2018. http://www.nusl.cz/ntk/nusl-391671.
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The master's thesis deals with alternative and non-traditional methods of violin playing especially for young children.
The master's thesis describes the philosophy, history and use of these methods. Shinichi's Suzuki Talent Education Method, Szilvay Colourstring Brothers Method, Violin.nu - Swedish Method. It contains questionnaire for teachers, pupils and parents, and its final evaluation.
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Zeráková, Jana. "Škola hry pro příčnou flétnu." Master's thesis, Akademie múzických umění v Praze.Hudební a taneční fakulta. Knihovna, 2018. http://www.nusl.cz/ntk/nusl-392812.
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The aim of this diploma thesis is to create, if possible, a comprehensive view of the methodology of the playing the flute.
The work includes a brief informations about history and development of the flute. It desribes individual parts of the flute, suitable production materials and appropriate instrument care. The work is also focused on holding the instrument, the flute playing posture, making a tone, embouchure, breathing, dynamics and vibrato. Part of my thesis is also devoted to pedagogy, it contains informations about the pupils' and educator's access to education and describes several options of proper exercising.
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Belaunde, Javier de, Praeli Francisco Eguiguren, Toma Víctor García, and Luis Pásara. "El sistema de justicia hoy." THĒMIS-Revista de Derecho, 2010. http://repositorio.pucp.edu.pe/index/handle/123456789/107950.
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Coloma, Manrique Carmen Rosa. "¿Qué significa ser niño hoy?" Pontificia Universidad Católica del Perú, 2012. http://repositorio.pucp.edu.pe/index/handle/123456789/117358.
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Matlasová, Kateřina. "Metodika hry na lesní roh." Master's thesis, Akademie múzických umění v Praze. Hudební fakulta AMU. Knihovna, 2008. http://www.nusl.cz/ntk/nusl-78147.
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The theme of the thesis is called the Methodology of French horn Playing. The text is divided into a few chaptures. After a short introduction I deal with the development of French horn with regard to the beginning of development in Bohemia. The third chapture brings us a short summary of particular methodology schools. Chaptures about holding the instrument, breathing and embouchure follow. The focal point of this thesis consists of chaptures about embouchure and breathing exercises.