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Pires, Bianca Catarina de Sousa. "Conceção de um dispositivo de micro-cromatografia hidrodinâmica para separação de células sanguíneas e visualização do mecanismo de separação." Master's thesis, Instituto Politécnico de Bragança, Escola Superior de Tecnologia e Gestão, 2012. http://hdl.handle.net/10198/8014.
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As células que compõem o sangue apresentam tamanhos diferentes. Estudos anteriores revelam que esta diferença de tamanhos leva a diferentes velocidades de migração das diferentes células em canais com diâmetros próximos das arteríolas. Este trabalho teve como intuito o estudo das velocidades de migração de glóbulos vermelhos (GVs) numa rede de canais formados por empacotamentos de esferas de vidro, este método é conhecido por cromatografia hidrodinâmica.
Para tal procedeu-se ao empacotamento de várias colunas tubulares com esferas de vidro de diferentes diâmetros. Foram feitos 5 empacotamentos nos quais os diâmetros médios das esferas eram 115, 150, 337,5, 875 e 2000µm. Para cada coluna empacotada fez-se passar no seu interior uma suspensão de GVs de ovelha em soro fisiológico (1% em volume de GVs), do qual se retirou o tempo de residência dos GVs para diferentes caudais: 0,25mL/min a 3 mL/min. Repetiu-se este procedimento para uma solução de sacarose a uma concentração de 1 g/L, também para os mesmos caudais, de forma a permitir o cálculo dos RRTs (a razão entre o tempo de residência dos GVs e o tempo de residência da sacarose), sendo estes valores menores que um na esmagadora maioria dos casos.
Os valores obtidos para os RRTs sugerem que alguns dos empacotamentos desenvolvidos podem ser utilizados para separar GVs de moléculas dissolvidas no sangue (como as proteínas), com dimensões da ordem de grandeza da sacarose, dado que os GVs se movem mais rapidamente no interior das colunas empacotadas do que moléculas dissolvidas de menor dimensão que os GVs. Determinou-se por microscopia que o diâmetro dos GVs de ovelha era cerca de 4,6µm.
Por fim, para haver uma maior perceção do fluxo sanguíneo no interior das colunas empacotadas produziram-se alguns microcanais em polidimetilsiloxano com características aproximadas às colunas empacotadas, onde se observou a formação de camadas livres de células e zonas de estagnação (em diferentes regiões dos microcanais). O primeiro fenómeno conduz a um aumento da velocidade de migração dos GVs enquanto o segundo conduz à retardação dos GVs. The cells that comprise the blood have different sizes. Previous studies have shown that this size difference can lead to different rates of migration of the cells in channels with diameters of the arterioles. This work aimed to study the migration velocities of red blood cells (GVs) through channels formed by the packing of glass beads, this method is known by hydrodynamic chromatography.
For this, different chromatographic columns were packed with glass beads of different diameters. Five packings were made for which the mean diameters of the spheres were 115, 150, 337,5, 875 and 2000µm. A suspension of GVs from sheep in physiological saline (with 1% Hct) was passed inside each packed column and the residence time of the GVs was calculated for different flow rates: 0,25mL/min to 3 mL/min. This procedure was repeated for a sucrose solution at a concentration of 1g/l to allow the calculation of RRTs (the ratio between the residence time of the GVs and residence time of sucrose), this values being inferior to one in the majority of the experiments. With the values obtained for the RRTs it was concluded that some of the developed packed columns can be used to separate the GVs from small molecules dissolved in the blood plasma (such as proteins), with dimensions of the order of magnitude of sucrose, since the GVs migrate faster through the packed columns than molecules smaller than them. Using a microscope it was possible to calculate the diameter of the GVs (around 4,6µm).
Finally, to have a greater perception of blood flow within the packed columns, it were produced microchannels constituted by polydimethylsiloxane with characteristics approximating the packed columns and it was possible to observe the formation of cell-free layers and zones of stagnation (at different regions of the microchannels). The former effect leads to the in-crease of the GVs velocities while the second one has an opposite influence in the GVs velocities.
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Bancayan, Vega Milagros. "Impacto de la gestión financiera y propuesta de mejora en la rentabilidad de la Corporación HDC S.A.C. Chiclayo 2013 – 2017." Bachelor's thesis, Universidad Católica Santo Toribio de Mogrovejo, 2019. http://hdl.handle.net/20.500.12423/2174.
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Actualmente las empresas carecen de una eficiente gestión financiera, haciéndolas vulnerables al mercado competitivo, el desconocer los puntos débiles de la gestión financiera traerá como consecuencia un desequilibrio financiero imprevisto, caracterizado por la poca liquidez, la insolvencia, deficiencias en su planificación financiera y control de recursos; esta investigación tiene como finalidad evaluar el impacto de la gestión financiera y establecer una propuesta de mejora en la rentabilidad de la Corporación HDC, cuyo objetivo fue evaluar la gestión financiera de la empresa, analizando sus estados financieros, diagnosticando su planificación y control de recursos financieros y estableciendo estrategias financieras para que ayuden a la empresa y a otras que se encuentren en similar situación a mejorar su gestión financiera, rentabilidad y por ende su desempeño empresarial. El tipo de investigación fue Aplicada – No Experimental; la población está conformada por la Corporación HDC, la muestra fueron los estados financieros de la Corporación; se aplicó el método Teórico – Descriptivo; asimismo la investigación se utilizó como instrumentos la Observación y la Documentación para la obtención de la información. La presente investigación concluyó, que la Corporación HDC no tiene una adecuada gestión financiera siendo esto una debilidad porque no le permite tener potencial financiero para cubrir sus deudas y hacer frente al mercado competitivo, debido a las cuentas por cobrar que tuvo y a que los ingresos por su actividad fueron utilizados para el pago de los leasings adquiridos, generando carencias de liquidez afectando la rentabilidad, razón por la cual es necesario hacer una propuesta para mejora de la rentabilidad mediante estrategias financieras.Tesis
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López, Yomayuza Claudia Carolina. "Charakterisierung der Tollwutvakzinen "Rabipur" und "Rabivac" und der enthaltenen Virusstämme FluryLEP und PM 1503." Giessen VVB Laufersweiler, 2009. http://d-nb.info/100020460X/04.
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Arzakantsyan, Mikayel. "Yb:YAG Laser Crystals with Controlled Doping Distribution." Phd thesis, Ecole Polytechnique X, 2013. http://pastel.archives-ouvertes.fr/pastel-00879616.
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Le développement de lasers solides de puissance-moyenne élevée doit faire face à des problèmes très spécifiques. La gestion de la thermique et de l'amplification de l'émission spontanée (ASE) pour de larges amplificateurs lasers deviennent des points clés lorsque l'augmentation de l'énergie de vient conséquente. Lucia est une chaîne laser de forte puissance moyenne qui repose sur le concept du miroir actif avec un cristal ou une céramique d'Yb:YAG comme milieu à gain. Comme pour d'autres systèmes lasers comparables, la distribution des ions actifs du milieu à gain est homogène en volume. Un profil variable du taux de dopage présente des avantages significatifs en termes de gain et par conséquent ouvre le chemin à une minimisation efficace des effets délétères de l'ASE et de l'échauffement. Cette thèse concerne la fabrication de tels milieux à gain. La méthode de croissance cristalline Bagdasarov, grâce à plusieurs de ses particularités, a permis d'obtenir plusieurs cristaux d'Yb:YAG avec profils de dopage variables contrôlés jusqu'à des valeurs de gradient de 3 at%/cm. Les résultats expérimentaux sont en bon accord avec les modèles mathématiques. Des simulations complémentaires de la température et du profil de gain montre que même avec des gradients plus faibles, les performances énergétiques des amplificateurs Lucia peuvent être améliorées jusqu'à 30%. Il est aussi alors possible d'utiliser des milieux à gain plus fins ce qui a pour conséquence positive une meilleure extraction de la chaleur. De larges cristaux d'Yb:YAG de 90 mm de diamètre ont été produits.
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Tsolakis, Apostolos V. "Characterization of Endocrine Cells and Tumours in the Stomach." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8804.
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Fendell, Robert, and Philemond Nordström. "Serverklustring." Thesis, Högskolan Kristianstad, Sektionen för hälsa och samhälle, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-13793.
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Klustring innebär att flera servrar arbetar tillsammans och på så sätt klarar av en uppgift som en ensam server inte skulle klara. Klustring kan också användas för att säkra drift med hjälp av en eller ett flertal servrar som väntar i startgropen om den aktiva servern som tillhandahåller tjänsten går ner. Detta examensarbete utfördes genom att först undersöka vilka klusterlösningar som fanns tillgängliga. Därefter utfördes intervjuer med företag som använde sig av olika typer av klustring. Laborationer gjordes för vidare undersökning av några av de mjukvaror som de intervjuade företagen använde. Det upptäcktes att variationen av lösningar hos de intervjuade företagen inte var så stor som förväntat innan arbetet påbörjades. Efter genomförd litteraturstudien och intervjumaterialet, för att sedan ge rekommendationer på vilka lösningar som bör väljas av exempelföretag utifrån vilka krav och kriterier som finns hos dessa.
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PRADO, Bruno Otávio Piedade. "HdSC: modelagem de alto nível para simulação nativa de plataformas com suporte ao desenvolvimento de HdS." Universidade Federal de Pernambuco, 2014. https://repositorio.ufpe.br/handle/123456789/12036.
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Com os grandes avanços recentes dos sistemas computacionais, houve a possibilidade de ascensão de dispositivos inovadores, como os modernos telefones celulares e tablets com telas sensíveis ao toque. Para gerenciar adequadamente estas diversas interfaces é necessário utilizar o software dependente do hardware (HdS), que é responsável pelo controle e acesso a estes dispositivos. Além deste complexo arranjo de componentes, para atender a crescente demanda por mais funcionalidades integradas, o paradigma de multiprocessamento vem sendo adotado para aumentar o desempenho das plataformas. Devido à lacuna de produtividade de sistemas, tanto a indústria como a academia têm pesquisado processos mais eficientes para construir e simular sistemas cada vez mais complexos. A premissa dos trabalhos do estado da arte está em trabalhar com modelos com alto nível de abstração e de precisão que permitam ao projetista avaliar rapidamente o sistema, sem ter que depender de lentos e complexos modelos baseados em ISS. Neste trabalho é definido um conjunto de construtores para modelagem de plataformas baseadas em processadores, com suporte para desenvolvimento de HdS e reusabilidade dos componentes, técnicas para estimativa estática de tempo simulado em ambiente nativo de simulação e suporte para plataformas multiprocessadas. Foram realizados experimentos com aplicações de entrada e saída intensiva, computação intensiva e multiprocessada, com ganho médio de desempenho da ordem de 1.000 vezes e precisão de estimativas com erro médio inferior a 3%, em comparação com uma plataforma de referência baseada em ISS.
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Prado, Bruno Otávio Piedade. "HdSC: modelagem de alto nível para simulação nativa de plataformas com suporte ao desenvolvimento de HdS." reponame:Repositório Institucional da UFS, 2014. https://ri.ufs.br/handle/riufs/1673.
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Com os grandes avanços recentes dos sistemas computacionais, houve
a possibilidade de ascensão de dispositivos inovadores, como os modernos
telefones celulares e tablets com telas sensíveis ao toque. Para gerenciar adequadamente
estas diversas interfaces é necessário utilizar o software dependente
do hardware (HdS), que é responsável pelo controle e acesso a estes
dispositivos. Além deste complexo arranjo de componentes, para atender a
crescente demanda por mais funcionalidades integradas, o paradigma de
multiprocessamento vem sendo adotado para aumentar o desempenho das
plataformas.
Devido à lacuna de produtividade de sistemas, tanto a indústria como a
academia têm pesquisado processos mais eficientes para construir e simular
sistemas cada vez mais complexos. A premissa dos trabalhos do estado da
arte está em trabalhar com modelos com alto nível de abstração e de precisão
que permitam ao projetista avaliar rapidamente o sistema, sem ter que
depender de lentos e complexos modelos baseados em ISS.
Neste trabalho é definido um conjunto de construtores para modelagem
de plataformas baseadas em processadores, com suporte para desenvolvimento
de HdS e reusabilidade dos componentes, técnicas para estimativa
estática de tempo simulado em ambiente nativo de simulação e suporte para
plataformas multiprocessadas. Foram realizados experimentos com aplica-
ções de entrada e saída intensiva, computação intensiva e multiprocessada,
com ganho médio de desempenho da ordem de 1.000 vezes e precisão de estimativas
com erro médio inferior a 3%, em comparação com uma plataforma
de referência baseada em ISS._________________________________________________________________________________________ ABSTRACT: The amazing advances of computer systems technology enabled the rise of
innovative devices, such as modern touch sensitive cell phones and tablets. To
properly manage these various interfaces, it is required the use of the Hardwaredependent
Software (HdS) that is responsible for these devices control and access.
Besides this complex arrangement of components, to meet the growing
demand for more integrated features, the multiprocessing paradigm has been
adopted to increase the platforms performance.
Due to the system design gap, both industry and academia have been researching
for more efficient processes to build and simulate systems with this
increasingly complexity. The premise of the state of art works is the development
of high level of abstraction and precise models to enable the designer
to quickly evaluate the system, without having to rely on slow and complex
models based on instruction set simulators (ISS).
This work defined a set of constructors for processor-based platforms modeling,
supporting HdS development and components reusability, techniques for
static simulation timing estimation in native environment and support for multiprocessor
platforms. Experiments were carried out with input and output intensive,
compute intensive and multiprocessed applications leading to an average
performance speed up of about 1,000 times and average timing estimation
accuracy of less than 3%, when compared with a reference platform
based on ISS.
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Zhou, Xuan. "RhoA GTPase Controls Cytokinesis and Programmed Necrosis of Hematopoietic Progenitors." University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1378197381.
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Burgisser, Alain. "HDR." Habilitation à diriger des recherches, Université d'Orléans, 2009. http://tel.archives-ouvertes.fr/tel-00447580.
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La Volcanologie moderne utilise des approches expérimentales, de terrain et théoriques pour mieux comprendre des phénomènes volcaniques critiques. Ces différents angles sont nécessaires en raison de l'extrême variation des échelles impliquées : des bulles de gaz de moins d'un millimètre libérant le gaz générant des panaches explosifs de plusieurs kilomètres de haut. La physique multiphasée, qui a pour objet d'étude l'écoulement de mixtures réactives de fluide et de particules, a permis des avancées dans l'unification de ces échelles. En combinant des lois à petite échelle, comme la croissance d'une bulle, des propriétés nouvelles émergent des simulations numériques, comme la ségrégation des bulles dans un conduit volcanique. De telles propriétés émergentes sont souvent valides à de grandes échelles et peuvent parfois être testées dans les systèmes naturels. La physique multiphasée reste cependant très jeune: les expérimentalistes qui déterminent les lois constitutives des systèmes les plus simples, les modélisateurs qui assemblent ces lois dans des modèles numériques complexes aux propriétés émergentes et les volcanologues de terrain qui mesures ces propriétés n'ont pas toujours le langage commun permettant de confronter leurs découvertes. Mes travaux ont eu pour but de trouver ce langage commun afin de faciliter l'intégration de nos connaissances sur les volcans. Cette intégration, renforcée dans le futur, pourrait ouvrir la possibilité d'unification de ces sous domaines. Allons-nous vers une unification de la Volcanologie ?
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Kremer, Laurent. "HDR." Habilitation à diriger des recherches, Université Montpellier II - Sciences et Techniques du Languedoc, 2007. http://tel.archives-ouvertes.fr/tel-00259336.
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Loume, Dieynaba. "Stratégie de protection de réseaux de transport d’électricité en courant continu multi-terminaux à l’aide de disjoncteurs mécaniques DC." Thesis, Université Grenoble Alpes (ComUE), 2017. http://www.theses.fr/2017GREAT048.
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Les réseaux de transport d’électricité multi-terminaux à courant continu se révèlent être la solution adéquate pour une intégration massive d’énergie renouvelable dans les réseaux alternatifs existants. En effet, les réseaux en courant continu sont capables de transmettre de manière efficace des niveaux de puissance élevés sur de très longues distances par rapport aux réseaux alternatifs car, à partir d'une certaine puissance à transmettre, il existe une distance limite à partir de laquelle la transmission d’énergie en courant alternatif perd sa compétitivité face à la transmission en courant continu. L'un des principaux défis liés au développement de ces réseaux de transport d’électricité à courant continu ou Supergrid, concerne leur protection contre des défauts de type court-circuit sur des liaisons en courant continu. . Dans ce travail de thèse, un nouveau concept de stratégie de protection des réseaux en courant continu à haute tension en cas de défaut court-circuit est proposé. La stratégie repose sur une philosophie de protection ayant comme priorité la suppression du courant de défaut avant l’isolation de la liaison en défaut. Elle est basée sur l’utilisation de disjoncteurs mécaniques à courant continu sans avoir recours à des limiteurs de courant de défaut. Une séquence de protection primaire ainsi que deux séquences de sauvegarde en cas de défaillance de disjoncteurs ont été développées, testées et validées à l’aide de simulations de transitoires électromagnétiques et de simulations temps-réel. En outre, les algorithmes des relais de protection ont été implémentés avec l'aide de l’outil d’analyse fonctionnelle descendante SADT (Structured Analysis and Design System). Cette thèse a été effectuée dans le cadre du SuperGrid Institute, une plate-forme de recherche collaborative visant à développer des technologies pour les futurs réseaux de transport d'électricité et regroupant l'expertise d'industries telles que GE Grid Solutions et les laboratoires de recherche publique comme le laboratoire de génie électrique de Grenoble (G2Elab)Multi-terminal High Voltage Direct Current (MTDC) grids,have been proven to be an adequate solution for massive integration of renewable energy power to existing High Voltage Alternating Current (HVAC) grids. Indeed, HVDC grids are capable of transmitting efficiently high level of power over very long distances compared to HVAC grids since, from a certain power to be transmitted, there is a limited distance from which the AC power transmission loses its efficiency and becomes very costly compared to DC power transmission. One of the main challenges related to the development of theses multi-terminal HVDC grids, or Supergrids, concerns their protection against DC short-circuit faults. In this thesis, a new concept of protection strategy for MTDC grids in case of permanent short-circuit fault on a DC cable has been proposed. The strategy is based on the non-selective fault clearing philosophy where the priority is given to the suppression of the fault current before isolating the faulty transmission line. The strategy is based on mechanical DC breakers and no fault current limiting devices are used. A primary protection sequence as well as two back-up sequences in case of breakers operation failure have been developed, tested and validated through Electromagnetic Transient (EMT) and Real-Time (RT) simulations. Also, algorithms to be implemented on protective relays have been designed with the help of the Structured Analysis and Design System (SADT). This PhD thesis has been performed in the frame of the SuperGrid Institute, a collaborative research platform aiming to develop technologies for the future electricity transmission network and bringing together the expertise of industries such as GE grid solutions and public research laboratories as the Grenoble Electrical Engineering Laboratory (G2Elab)
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Gott, Travis Matthew. "Spectroscopic and Kinetic Studies of Hydrodenitrogenation and Hydrodesulfurization over Supported Nickel Phosphide (Ni2P)." Diss., Virginia Tech, 2008. http://hdl.handle.net/10919/29536.
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This dissertation describes preparation and characterization of Ni2P catalysts and their application in hydrodesulfurization (HDS) and hydrodenitrogenation (HDN). The work carried out includes synthesis of Ni2P on different siliceous supports, SiO2 and MCM-41. It also includes characterization of these catalytic materials using X-ray diffraction (XRD), temperature-programmed reduction (TPR), Fourier transform infrared (FTIR) spectroscopy and X-ray absorbance fine structure (XAFS) spectroscopy. In situ FTIR was employed to study the acidity of Ni2P/SiO2 and probe the catalytic sites involved in the HDN of pyridine. Transient and steady-state kinetics of a surface intermediate that is formed upon pyridine adsorption and reaction was studied to elucidate the mechanism of HDN over Ni2P/SiO2. Additionally, in situ FTIR and X-ray absorption near edge structure (XANES) spectroscopy was utilized to probe the bonding, mechanism and kinetics of thiophene HDS over a novel MCM-41-supported Ni2P catalyst. The use of these techniques allowed for better understanding of the surface intermediates, mechanisms and the nature of the active sites involved in HDN and HDS.Ph. D.
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Lee, Yong-Kul. "Reactivity and Structure of Supported Nickel Phosphides (Ni2P) in Deep Hydrodesulfurization Catalysis." Diss., Virginia Tech, 2004. http://hdl.handle.net/10919/30228.
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This dissertation describes preparation and characterization of Ni2P catalysts and their application in deep hydrodesulfurization (HDS) of a model sulfur compound, 4,6-dimethyldibenzothiophene (4,6-DMDBT), one of the most refractory S-compounds. This topic is of great importance in addressing recently enacted environmental regulations limiting the sulfur content in fuels. The work carried out includes synthesis of Ni2P on different siliceous supports, SiO2, MCM-41, and ultra-stable Y zeolite (USY). It also includes determining the characteristics of the supported Ni2P catalysts with a wide range of techniques: X-ray powder diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared (FTIR) and X-ray absorption fine structure (XAFS) spectroscopy. The use of these techniques allowed better understanding of the nature of the active sites as well as the effect of supports. Activity tests were conducted in the HDS of 4,6-DMDBT and the HDN of quinoline. The performance of the catalysts will be compared to that of a conventional sulfide hydrotreating catalyst, Ni-Mo-S/Al2O3. Investigation of the reaction mechanism in the hydrodenitrogenation (HDN) of 2-methylpiperidine together with in situ FT-IR measurements were conducted to understand how catalyst properties affect activity and selectivity.Ph. D.
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Zelenková, Jana. "Přístupy k měření chudoby se zaměřením na členské státy EU." Master's thesis, Vysoká škola ekonomická v Praze, 2014. http://www.nusl.cz/ntk/nusl-201951.
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This thesis focuses on current approaches to the measurement of poverty. The aim of the thesis is to evaluate if measuring poverty indicators and quality of life indicators used by United Nations Development Programme and Eurostat are meaningful enough. The theoretical part is an analysis of chosen indicators. The theoretical knowledge is followed by practical part, comparing poverty levels in member states of the European Union, and giving deeper insight into the analysis of sub-indicators. Furthermore, the thesis looks at informative value connected to mutual relations among the indicators. The comparison reveals that the level of human development is negatively related to aspects such as insufficient economic growth, inequality and low level of wealth redistribution. From an analytical point of view, new multi-criteria indicators are useful enough for the purpose of research on this topic, in spite of certain imperfections.
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Fernlund, Fredrik, and Markus Koskinen. "HDR in production." Thesis, Linköpings universitet, Institutionen för teknik och naturvetenskap, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-95329.
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HDR (High Dynamic Range) är en teknik som gör det möjligt att fånga in ett större dynamiskt omfång en vad en vanlig bild skulle klara av. Användningsområdena för sådana HDR-bilder är många men företag inom mspel- och film- och visualiseringsindustrin använder ofta bilderna för virtuell ljussättning, däribland Syndicate Entertainment. Det är ett filmproduktionsbolag beläget i Stockholm där examensarbetet delvis är utfört. Idén bakom examensarbetet är att den komplicerade och långsamma processen att skapa HDR-bilderna bör kunna effektiviseras. En utförd enkätundersökning ligger tillsammans med litteraturstudier och kontakt med handledare på företaget och skolan som grund för en framtagen arbetsgång. Arbetsgången är den kedja av processer som krävs för att skapa en HDR-bild och vidare en ljusmapp. Denna arbetsgång granskas kritiskt där förslag på förbättringar redovisas. Förutom granskningen har en demonstrationsapplikation utvecklats. Det finns två syften med denna applikation. Syftena är dels att tillgodose företagets önskemål om att erhålla en applikation som går att använda i praktiken, dels för att realisera och testa några av de framtagna effektiviseringsteorierna.
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Ozdarska, Katarzyna. "Synthèses d’inhibiteurs de HDAC et leurs tests biologiques (Cytotoxicité, HDAC inhibition)." Thesis, Reims, 2020. http://www.theses.fr/2020REIMS023.
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L’épigénétique représente les modifications de l’expression génique, sans altérer la séquence nucléique de l'ADN. L'un des mécanismes de régulation est le remodelage de la chromatine qui s’effectue via les histones acétyltransférases et les histones désacétylases (HDAC) permettant ou non la transcription de gènes. Une expression anormale des HDAC est corrélée à de nombreuses maladies (dépendance à l'alcool, inflammation ainsi que les maladies cardiovasculaires et neurodégénératives, cancers…). Il est primordial de cibler la sélectivité d’une isoforme parmi les 11 connues des HDAC zinc dépendantes pour éviter les effets secondaires. Le but de la recherche était de concevoir et de synthétiser de nouveaux composés, de vérifier leur activité inhibitrice vis-à-vis des HDAC de classe I ou II et leur cytotoxicité sur quatre lignées cellulaires: HaCaT, V79-4, SH-SY5Y et PC12. Ainsi, nous nous sommes concentrés sur les pharmacomodulations du ZBG, de l’espaceur et de la tête de molécules connues tels que le MS-275 (sélectif de la classe I des HDAC), les SAHA et TSA (espaceur en C5 ou C6) avec une forte activité inhibitrice vis-à-vis des HDAC, mais non sélectifs. Nous nous sommes concentrés sur les pharmacomodulations de l'HDACI connu modifiant le domaine de liaison au zinc ZBG (sulfonylhydrazide, catéchol), la nature de l’espaceur (alkyl, aryl) et le groupe de reconnaissance de surface (bis-aryl, adamantyl, indolopyridazinone). Une bibliothèque de 57 nouveaux composés a été créée en trois séries. Aucun d'entre eux n'a montré d'activité inhibitrice satisfaisante. Les composés sélectionnés n'ont pas montré d'activité cytotoxique sur les lignées de cellules neuronales. Sur la base de cette recherche, il est possible de créer de nouveaux composés dans la série indolopyridazinone afin de les testerEpigenetics represents changes in gene expression without altering the nucleic sequence of DNA. One of the main mechanisms of regulation of gene expression is chromatin remodeling via histone acetyltransferases and histone deacetylases (HDAC), which may or may not allow gene transcription. An abnormal expression of HDACs is correlated with many diseases (alcohol dependence, inflammation as well as cardiovascular and neurodegenerative diseases, cancers...). It is essential to target the selectivity of one isoform among the 11 known zinc-dependent HDACs to avoid side effects. The aim of the research was to design and synthesize new compounds, verify their inhibitory activity against class I or II HDACs and their cytotoxicity on four cell lines: HaCaT, V79-4, SH-SY5Y and PC12. We focused on the pharmacomodulations of ZBG, the linker and the cap of known molecules such as MS-275 (selective for class I of HDACs), SAHA and TSA (spacer in C5 or C6) with a strong inhibitory activity towards HDACs, but not selective. We concentrated on the pharmacomodulations of known HDACI modifying the zinc binding domain (sulfonylhydrazide, catechol), the nature of the spacer (alkyl, aryl) and the surface recognition group (bis-aryl, adamantyl, indolopyridazinone). A library of 57 new compounds was designed in three series. None of them showed satisfactory inhibitory activity. The selected compounds did not show cytotoxic activity on neuronal cell lines. Based on this research, it is possible to create new compounds in the indolopyridazinone series in order to test them
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Regiani, Anelise Maria. "Eletrólitos sólidos poliméricos à base de polissacarídeos: síntese e caracterização." Universidade de São Paulo, 2000. http://www.teses.usp.br/teses/disponiveis/75/75131/tde-18092001-165107/.
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A síntese e a caracterização de um novo tipo de eletrólito sólido polimérico são descritas neste trabalho. Os materiais preparados consistiram de filmes de hidroxietil celulose ou hidroxipropil celulose entrecruzadas com diisocianatos de poli(óxido de etileno) e poli(óxido de propileno) ou enxertadas com monoisocianato de poli(óxido de propileno). Todos estes isocianatos foram sintetizados a partir das respectivas aminas comerciais. Filmes de hidroxietil celulose entrecruzada com hexametileno diisocianato ou enxertados com fenil isocianato também foram estudados. Como técnicas de caracterização foram utilizadas espectroscopia no infravermelho, no ultravioleta e de ressonância magnética nuclear, análises térmicas e difração de raios-X. Os filmes dopados com LiClO4 foram caracterizados utilizando-se as mesmas técnicas e a condutividade foi determinada através do método de impedância complexa. Os resultados foram da ordem de 10-5 Scm-1 a 60oC. Este valor permitiu concluir que as cadeias de derivado de celulose parecem não influenciar no fenômeno de condução; aparentemente este encontra-se mais relacionado ao tipo de isocianato utilizado na formação do filme. Os resultados de condutividade e de mobilidade de cadeia polimérica indicam que os sistemas aqui estudados podem ser aplicados como eletrólitos sólidos poliméricos. Os filmes com isocianatos comerciais, no entanto não apresentaram resultado de condução interessante.The synthesis and characterization of new types of solid polymer electrolytes based on hydroxyethyl and hydroxypropyl cellulose grafted with different polyethers were investigated. The synthesis is based on the reaction between the cellulose derivative and mono and difunctional isocyanates prepared from amines of polyethylene oxide and polypropylene oxide. It were also synthesized films of hydroxyethyl cellulose grafted with hexamethylene diisocyanate and phenylisocyanate. These materials were characterized through techniques of infrared, ultraviolet and nuclear magnetic ressonance spectroscopies, thermal analysis and X-ray diffraction. The films of polysaccharide and polyether that contained LiClO4 showed conductivity values of the order of 10-5 Scm-1 at 60oC. The value of this parameter seems to be independent of the cellulose derivative parameters and it is better related to the type of isocyanate grafted on the polysaccharide chain. The conductivity and chain mobility results show that the systems studied here can be applied as solid polymer electrolytes. The materials synthesized using commercial isocyanates as grafting reactant did not show interesting conductivity response.
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Vančura, Jan. "Tone-mapping HDR obrazů." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2010. http://www.nusl.cz/ntk/nusl-237159.
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This thesis concerns with the introduction to the problematics of images with high dynamic range (HDR) and possibilities of HDR images compression options for display on devices with a low dynamic range (LDR). In the introduction is described historical evolution of recording of reality. It is focusing towards point of view of physics, human visual perception and digital recording. There are described the ways of generating and holding of HDR images. The thesis is corncerned to the techniques of HDR compression, it means the tone-mapping. The different techniques of tone-mapping are explained and specific aproach is targeted to the gradient domain high dynamic range compresion.
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Čurda, Pavel. "Měřicí přístroj HDO signálů." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2019. http://www.nusl.cz/ntk/nusl-400610.
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The thesis deals with the introduction of the measuring instrument SVA - M on the market for compliance with electromagnetic compatibility and electrical safety requirements. Furthermore it deals with determination of measuring accuracy instrument SVA - M and measurement uncertainties. For the determination of accuracy there is a theoretical analysis and subsequent practical measurements.
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Bonnard, Jennifer. "Génération d'images 3D HDR." Thesis, Reims, 2015. http://www.theses.fr/2015REIMS014/document.
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L’imagerie HDR et l’imagerie 3D sont deux domaines dont l’évolution simultanée mais indépendante n’a cessé de croître ces dernières années. D’une part, l’imagerie HDR (High Dynamic Range) permet d’étendre la gamme dynamique de couleur des images conventionnelles dites LDR (Low Dynamic Range). D’autre part, l’imagerie 3D propose une immersion dans le film projeté avec cette impression de faire partie de la scène tournée. Depuis peu, ces deux domaines sont conjugués pour proposer des images ou vidéos 3D HDR mais peu de solutions viables existent et aucune n’est accessible au grand public. Dans ce travail de thèse, nous proposons une méthode de génération d’images 3D HDR pour une visualisation sur écrans autostéréoscopiques en adaptant une caméra multi-points de vue à l’acquisition d’expositions multiples. Pour cela, des filtres à densité neutre sont fixés sur les objectifs de la caméra. Ensuite, un appareillement des pixels homologues permet l’agrégation des pixels représentant le même point dans la scène acquise. Finalement, l’attribution d’une valeur de radiance est calculée pour chaque pixel du jeud’images considéré par moyenne pondérée des valeurs LDR des pixels homologues. Une étape supplémentaire est nécessaire car certains pixels ont une radiance erronée. Nous proposons une méthode basée surla couleur des pixels voisins puis deux méthodes basées sur la correction de la disparité des pixels dontla radiance est erronée. La première est basée sur la disparité des pixels du voisinage et la seconde sur la disparité calculée indépendamment sur chaque composante couleur. Ce pipeline permet la générationd’une image HDR par point de vue. Un algorithme de tone-mapping est ensuite appliqué à chacune d’elles afin qu’elles puissent être composées avec les filtres correspondants à l’écran autostéréoscopique considéré pour permettre la visualisation de l’image 3D HDRHDR imaging and 3D imaging are two areas in which the simultaneous but separate development has been growing in recent years. On the one hand, HDR (High Dynamic Range) imaging allows to extend the dynamic range of traditionnal images called LDR (Low Dynamic Range). On the other hand, 3Dimaging offers immersion in the shown film with the feeling to be part of the acquired scene. Recently, these two areas have been combined to provide 3D HDR images or videos but few viable solutions existand none of them is available to the public. In this thesis, we propose a method to generate 3D HDR images for autostereoscopic displays by adapting a multi-viewpoints camera to several exposures acquisition.To do that, neutral density filters are fixed on the objectives of the camera. Then, pixel matchingis applied to aggregate pixels that represent the same point in the acquired scene. Finally, radiance is calculated for each pixel of the set of images by using a weighted average of LDR values. An additiona lstep is necessary because some pixels have wrong radiance. We proposed a method based on the color of adjacent pixels and two methods based on the correction of the disparity of those pixels. The first method is based on the disparity of pixels of the neighborhood and the second method on the disparity independently calculated on each color channel. This pipeline allows the generation of 3D HDR image son each viewpoint. A tone-mapping algorithm is then applied on each of these images. Their composition with filters corresponding to the autostereoscopic screen used allows the visualization of the generated 3DHDR image
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Mustafa, Mufaddal. "Alterations in Genomic 5-Hydroxymethylcytosine Level in Hepatocellular Cancer." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1366115027.
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Stenback, Rachel Elisabeth. "H.C. Andersen : en etnologisk sagostudie." Thesis, Uppsala University, Department of Cultural Anthropology and Ethnology, 2001. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4710.
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Holm, Åsa. "Mathematical Optimization of HDR Brachytherapy." Doctoral thesis, Linköpings universitet, Optimeringslära, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-99795.
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One out of eight deaths throughout the world is due to cancer. Developing new treatments and improving existing treatments is hence of major importance. In this thesis we have studied how mathematical optimization can be used to improve an existing treatment method: high-dose-rate (HDR) brachytherapy. HDR brachytherapy is a radiation modality used to treat tumours of for example the cervix, prostate, breasts, and skin. In HDR brachytherapy catheters are implanted into or close to the tumour volume. A radioactive source is moved through the catheters, and by adjusting where the catheters are placed, called catheter positioning, and how the source is moved through the catheters, called the dwelling time pattern, the dose distribution can be controlled. By constructing an individualized catheter positioning and dwelling time pattern, called dose plan, based on each patient's anatomy, it is possible to improve the treatment result. Mathematical optimization has during the last decade been used to aid in creating individualized dose plans. The dominating optimization model for this purpose is a linear penalty model. This model only considers the dwelling time pattern within already implanted catheters, and minimizes a weighted deviation from dose intervals prescribed by a physician. In this thesis we show that the distribution of the basic variables in the linear penalty model implies that only dwelling time patterns that have certain characteristics can be optimal. These characteristics cause troublesome inhomogeneities in the plans, and although various measures for mitigating these are already available, it is of fundamental interest to understand their cause. We have also shown that the relationship between the objective function of the linear penalty model and the measures commonly used for evaluating the quality of the dose distribution is weak. This implies that even if the model is solved to optimality there is no guarantee that the generated plan is optimal with respect to clinically relevant objectives, or even near-optimal. We have therefore constructed a new model for optimizing the dwelling time pattern. This model approximates the quality measures by the concept conditional value-at-risk, and we show that the relationship between our new model and the quality measures is strong. Furthermore, the new model generates dwelling time patterns that yield high-quality dose distributions. Combining optimization of the dwelling time pattern with optimization of the catheter positioning yields a problem for which it is rarely possible to find a proven optimal solution within a reasonable time frame. We have therefore developed a variable neighbourhood search heuristic that outperforms a state-of-the-art optimization software (CPLEX). We have also developed a tailored branch-and-bound algorithm that is better at improving the dual bound than a general branch-and-bound algorithm. This is a step towards the development of a method that can find proven optimal solutions to the combined problem within a reasonable time frame.
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Bergmeier, Christoph. "Paraoxonaseprofil im Dichtebereich der HDL /." Berlin : WVB, Wissenschaftlicher Verlag Berlin, 2005. http://www.wvberlin.de/data/inhalt/bergmeier.htm.
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Rico, Romo Juan Humberto. "HDL-level partitioning of circuits." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ58798.pdf.
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Ferretti, Davide. "Immagini HDR: Principi e applicazioni." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2021.
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Questa tesi presenta il mondo delle immagini HDR, soffermandosi sulla descrizione dei principi su cui si basa la loro formazione via hardware e sulla loro generazione tramite software, fino ad arrivare a descrivere alcuni formati di file che permettono il salvataggio ed una serie di applicazioni che ne richiedono l’utilizzo in situazioni pratiche
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Musil, Martin. "HDR obrazy a jejich zpracování." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2013. http://www.nusl.cz/ntk/nusl-236195.
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HDR images have much wider range of luminance values, than photographs created and displayed in a standard 24-bit format. There are several ways to create images with high dynamic range, but this diploma thesis focuses just on one of them, and it is the method of composing out of series of standard photographs. The goal of the first part of the text consists of studying, understanding and eventually writing down the basic terms and knowledge in the subject of image composition and other processes, necessary to create HDR photographs. Next the procedure of creating images with high dynamic range, processing and converting them into viewable form, is described. The following chapter contains the design of the application, which creates this kind of photographs, and which is smoothly changing into its actual implementation afterwards. The process of experimenting and its results are presented and discussed firstly in their own chapter and secondly in the attachment. The conclusion contains the summary of the work and the options of possible expansion.
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Nejezchleb, Ivan. "Tone-mapping pro HDR obrazy." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2009. http://www.nusl.cz/ntk/nusl-236674.
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This thesis focuses on the high dynamic range (HDR) imaging problematic. It describes process of capturing and storage of HDR images in brief. Main part of thesis deals with techniques of how to display HDR images on common visual display devices, which are not able to represent them directly. This process is called tone-mapping. It is firstly described in general and than the text focuses on several techniques of tone-mapping, mainly on tone-mapping using bilateral filtering.
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Wang, Ke. "Investigation of total HDL and HDL subclass kinetics using stable isotope techniques in healthy subjects." Thesis, University of Surrey, 2015. http://epubs.surrey.ac.uk/807836/.
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Background: HDLs are heterogeneous particles, and apoA-I is the major apolipoprotein in human HDL. CVD is a multifactorial condition, and a various lipids and lipoproteins in the plasma are involved in the development of CVD. It has been suggested that HDLs have an inverse association with the risk of CVD. A high sugar intake (especially fructose and sucrose) was found to associate with a low HDL-C level and increased risk of CVD. However, the effect of dietary sugar on HDL kinetics is unclear. An insight of HDL subclass kinetics may provide a better understanding of the whole dynamic of HDL metabolism. Methods: Two studies were undertaken: 1) A controlled, randomized crossover dietary intervention study was carried out in 6 overweight middle-aged men. Subjects underwent two 12-week dietary interventions with high and low non-milk extrinsic sugar diets. Total HDL kinetics was measured using a primed constant intravenous infusion of [1-13C] leucine for 10 hours. 2) A HDL subclass kinetic study was carried out in 6 healthy subjects (3 males and 3 females). An intravenous bolus injection of [1-13C] leucine was applied to measure HDL subclass kinetics. Blood samples were taken during a 10-hour study and the following 2 weeks. Total HDL, HDL2 and HDL3 were separated from the plasma by ultracentrifugation, and αHDL and preβHDL were isolated by agarose gel electrophoresis. ApoA-I in HDL fractions was separated by SDS-PAGE. After purification, hydrolysis and derivatization, the isotopic enrichment of apoA-I in HDL was measured by GC-MS and apoA-I fractional catabolic rate (FCR) and production rate (PR) was calculated for each subclass and total HDL. Results: In the dietary intervention study, the FCR of total HDL apoA-I on the high and low sugar diet (0.20 ± 0.02 and 0.18 ± 0.02 pools/day) was similar, as was the PR (7.33 ± 0.66 and 6.05 ± 0.72 mg/kg/day respectively). In the HDL subclass study, the concentration of αHDL apoA-I (0.97 ± 0.05 g/L) was significantly higher than that of preβHDL apoA-I (0.15 ± 0.03 g/L) (p<0.001). The FCR of αHDL and preβHDL apoA-I was 0.10 ± 0.02 and 0.13 ± 0.04 pools/day, and the PR of αHDL and preβHDL apoA-I was 3.94 ± 0.73 and 0.67 ± 0.12 mg/kg/day respectively. The concentration of HDL3 apoA-I (0.68 ± 0.04 g/L) was significantly higher than that of HDL2 apoA-I (0.23 ± 0.06 g/L) (p=0.002). The FCR of HDL2 and HDL3 apoA-I was 0.15 ± 0.02 pools/day for both, and PR of HDL2 and HDL3 apoA-I was 1.35 ± 0.35 2 and 3.81 ± 0.51 mg/kg/day respectively. A significant difference was observed between αHDL and preβHDL apoA-I PR (p=0.010), and between HDL2 and HDL3 apoA-I PR (p=0.030) in the whole group. The concentration of HDL2 apoA-I was higher in women (0.32 ± 0.08 g/L) than men (0.13 ± 0.02 g/L) though the difference was not significant. HDL2 apoA-I PR was significantly higher in women than men (p=0.017). Conclusion: The high and low sugar diet did not affect HDL metabolism in overweight men. The higher apoA-I concentration of αHDL and HDL3 might be due to the higher apoA-I PR of αHDL and HDL3 compared to preβHDL and HDL2 respectively in healthy subjects. The higher level of HDL2 apoA-I in female than male subjects might be due to the higher PR of HDL2 apoA-I in women.
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Lukáč, Ľuboš. "Udržitelnost sociální situace obyvateľstva v období hospodářské krize." Master's thesis, Vysoká škola ekonomická v Praze, 2010. http://www.nusl.cz/ntk/nusl-72281.
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Abstract The role of the thesis is to analyze the financial situation of households and changes in living standards in Slovakia since 2000 through the creation of economic crisis to the present. In the thesis are described in detail information about unemployment, income and economically active population, but also the inflow of foreign investment, social security, household indebtedness of individuals and social situation in the Slovak Republic. These indicators compared with countries of European Union Member States. This topic is very interested because of its topicality. I chose Slovakia for two reasons. The first is that I am citizen of the Slovak Republic and the second is the availability of statistical data and work with them. Keywords: social situation, GDP, HDI, unemployment, poverty, FDI
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Labza, Sönke [Verfasser]. "Der Einfluss von HDL und dem HDL-assoziierten Sphingosin-1-Phosphat auf proinflammatorische Signalwege / Sönke Labza." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2010. http://d-nb.info/1025087933/34.
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Bettinger, Dominik [Verfasser], and Hans Christian [Akademischer Betreuer] Spangenberg. "HCC-Biomarker in der Diagnostik und Therapie des Hepatozellulären Karzinoms (HCC) in verschiedenen Phasen der Erkrankung." Freiburg : Universität, 2013. http://d-nb.info/112347575X/34.
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Höbbel, Gunnar. "Untersuchungen zur bifunktionellen Rolle von HDL." [S.l.] : [s.n.], 1999. http://www.sub.uni-hamburg.de/disse/93/Diss1999.pdf.
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Lord, Mikael. "Adaptable rule checking tools for HDL." Thesis, Linköping University, Department of Electrical Engineering, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-16762.
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Today’s electronics in aviation (avionics) are more complex than ever before. With higher requirements on safety and reliability and with new SoC (System on Chip) technology, the validation and verification of designs meet new challenges. In commercial and military aircraft there are many safety-critical systems that need to be reliable. The consequences of a failure of a safety-critical system onboard a civil or military aircraft are immeasurably more serious than a glitch or a bit-flip in a consumer appliance or Internet service delivery. If possible hazards are found early in the design process, a lot of work can be saved later on. Certain structures in the code are prone to produce glitchy logic and timing problems and should be avoided. This thesis will strengthen Saab Avitronics knowledge of adaptable rule checking tools for HDL, with a market analysis of the tools available. Moreover will it evaluate two of the most suitable tools and finally it will describe some of the design issues that exist when coding safety-critical systems. Finally it is concluded that the introduction of static rule checking tools will help the validator to find dangerous constructs in the code. However, it will not be possible to fully automate rule checking for safety-critical systems, because of the high requirements on reliability.
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Kolkman-Deurloo, Inger Karine Kirsten. "Intraoperative HDR brachytherapy: present and future." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2007. http://hdl.handle.net/1765/8621.
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Pace, Gordon G. "Hardware design based on Verilog HDL." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298555.
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Leonce, Andrew. "HDR video enhancement, processing and coding." Thesis, Loughborough University, 2015. https://dspace.lboro.ac.uk/2134/19639.
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Advances in digital camera technology have led to the development of image sensors that are capable of capturing High Dynamic Range (HDR) images. Although this has enabled the capture of greater depths of colour and illumination, there remain problems with regards to transmitting and displaying the HDR image data. Current consumer level displays are designed to only show images with a depth of 8-bits per pixel per channel. Typical HDR images can be 10-bits per pixel per channel and upwards, leading to the first problem, how to display HDR images on Standard Dynamic Range (SDR) displays. This is linked to a further problem, that of transmitting the HDR data to the SDR devices, due to the fact that most state-of-the-art image and video coding standards deal with only SDR data. Further, as with most technologies of this kind, current HDR displays are extremely expensive. Furthermore, media broadcast organisations have invested significant sums of money into their current architecture and are unwilling to completely change their systems at further cost.
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Vacek, Tomáš. "Vývoj HDP, strukturální analýza, postavení zemědělství." Master's thesis, Česká zemědělská univerzita v Praze, 2016. http://www.nusl.cz/ntk/nusl-257153.
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This master thesis deals with the gross domestic product as one of the basic macroeconomic indicators. The subject of the work is also examining the situation of Czech agriculture.
The work presents theoretical basis for understanding the basic relations and concepts that relate to the gross domestic product. They describe the various methods of GDP calculation and underlying economic factors, which contribute to the final value of GDP. In detail, the work deals with the development of Czech gross domestic product since 1993, and its comparison with not only with neighboring states, but also with other European Union countries.
The last part deals with the position of Czech agriculture and its development since 2003. In addition, he also position of individual plant and animal production, number of employees and contribution to gross domestic product.
In the final part, the work tries to summarize the trend of the gross domestic product of the Czech Republic and agriculture as its integral part.
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Polášek, Jaromír. "Implementace protokolu HDLC v síťových simulátorech." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2018. http://www.nusl.cz/ntk/nusl-377008.
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This diploma thesis deals with the possibility of using HDLC (High-Level Data Link Control) protocol for communication and addressing of smart metering devices with a data concentrator. The HDLC protocol is used in two DLMS/COSEM (Device Language Message Specification/Companion Specification for Energy Metering) communication profiles. To simulate these communication profiles, the most appropriate simulation program is selected. Using this simulator, the first communication profile is implemented and the second one is designed. Communication profile based on TCP/IP (Transmission Control Protocol/Internet Protocol) has been fully implemented. To implement the three-layer HDLC communication profile, all options have been thoroughly explored. Using these findings, a process was designed to guide the full implementation. For the first communication profile the qualitative parameters are measured, which are then plotted and evaluated.
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Martinů, Lukáš. "Skládání HDR obrazu pro pohyblivou scénu." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2015. http://www.nusl.cz/ntk/nusl-234925.
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Master's thesis is focused on capturing of low dynamic range images using common devices such as camera and its multiple exposure. The main part of thesis is dedicated to composing these images to HDR image, inclusive sequence of images of static scenes, but also dynamic ones. Next part describes tone mapping used for display HDR image on LDR monitors. Moreover, there is given design and implementation of application solving problems mentioned earlier. In the end, the implemented application is evaluated and the possible continuation of this work is stated.
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Müllerová, Věra. "Kompenzace obrazových artefaktů v HDR obrazu." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2015. http://www.nusl.cz/ntk/nusl-264942.
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Tato diplomová práce se zabývá syntézou HDR obrazu (High Dynamic Range Imaging). HDRI technologie se stala v posledních letech velice populární. Běžný a nejvíce používaný způsob vytvoření HDR obrazu je spojení více snímků stejné scény pořízených pomocí různých expozičních časů. Tato technika funguje správně pouze v případě, že se jedná o statickou scénu. Pokud je však ve scéně nějaký pohyb ve chvíli, kdy se pořizují snímky dané scény, výsledný HDR obraz obsahuje artefakty zvané jako duchy. V této práci jsou prezentovány základní informace o HDRI se zaměřením na metody odstraňující artefakty z HDR obrazů. Práce shrnuje již existující metody a dvě z nich - tzv. bitmap movement detection a histogram based ghost detection - představuje jako vhodné pro použití v real-time skládání HDR obrazu a pro implementaci na FPGA (Field-Programmable Gate Array) architektuře. Tyto metody jsou v práci implementovány v programovacím jazyce C++ jako prototypy. Navíc je zde navržena modifikace metody založené na výpočtu histogramu pro jednodušší a efektivnější implementaci na FPGA architektuře.
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Svatý, Lukáš. "HDR video "plugin" pro Adobe Premier." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2015. http://www.nusl.cz/ntk/nusl-264960.
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Cílem práce je vytvoření podpory pro editovaní videa v HDR formátu. Pro editaci videa je zvolen program Adobe Premiere Pro a na dosažení požadovaného výsledku je vytvořen plugin do zmiňovaného softwaru, který poskytuje požadovanou funkcionalitu. V práci jsou vysvětleny principy vytváření, zobrazení a ukládáni obsahu z rozšíreným dynamickým rozsahem. Zároveň jsou vysvětleny principy vytváření pluginů pro Adobe Premiere Pro za pomoci SDK verze CS6. V praktické části této práce jsou vysvětleny detaily implementace, problémy, které byly řešené, a popis samotného pluginu. Návrh pluginů je vytvořen tak, aby byla možná další práce na tomto softwaru, přidaní další funkcionality a pro umožnění využití tohoto díla na rozvoji obsahu s rozšíreným dynamickým rozsahem.
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Staněk, Jiří. "Metody temporálního tone-mappingu HDR videa." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2019. http://www.nusl.cz/ntk/nusl-403155.
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The diploma thesis provides the theoretical background needed to understand the complex topic of high dynamic range, and deals with the implementation of an innovative method for temporal video tone-mapping. At first, high dynamic range image acquisition, storage and processing are described. Afterwards, a general introduction to tone-mapping, description of undesirable image artifacts and an overview of existing state-of-the-art algorithms are presented. The part which follows focuses on the implementation of the chosen method and proposes several additional enhancements of the initially selected algorithm. Based on the information provided, an application with an intuitive graphical interface, which can be used for temporal HDR video tone-mapping, has been created. Finally, the the achieved results are demonstrated and visually compared with existing methods for temporal video tone-mapping.
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Wang, Xiaojing. "Cost- benefit Models for HDV Platooning." Thesis, KTH, Skolan för elektro- och systemteknik (EES), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-200533.
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Klimentová, Veronika. "Nezaměstnanost a HDP - analýza vzájemných vztahů." Master's thesis, Vysoká škola ekonomická v Praze, 2014. http://www.nusl.cz/ntk/nusl-193368.
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The present thesis describes the relation of the gross domestic product and the unemployment rate by educational attainment. The analysis of relation between time series refers to data for the Czech Republic. The thesis is divided into four main chapters. The first chapter deals with the definition of the gross domestic product, the calculation method, the detection and the measurement. The following chapter is focused on the issue of unemployment. Both the chapters are supplemented by historical development of indicators in the Czech Republic. The last theoretical part presents the statistical methods used in the time series analysis. The fourth chapter provides the actual analysis of relations between the gross domestic product and the unemployment rate by educational attainment. The analysis is based on data for the period 1996--2014, which are quarterly seasonally unadjusted data.
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Khan, Omar Ali. "HR23B, a biomarker for HDAC inhibitors." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:9cd76c0b-e70e-43f7-a92d-a99f403a077e.
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As our understanding of cancer biology increases and novel therapies are developed, an increasing number of predictive biomarkers are becoming clinically available. Aberrant acetylation has been strongly linked to tumourigenesis and the modulation of acetylation through targeting histone deacetylase (HDAC) has led to the introduction of many HDAC inhibitors. To date, two have had regulatory approval for the treatment of cutaneous T cell lymphoma (CTCL). Modifications in chromatin control underpin the mechanism of action of HDAC inhibitors. A genome wide loss-of-function screen identified HR23B as a gene that governs sensitivity to HDAC inhibitors. HR23B shuttles ubiquitinated cargo proteins to the proteasome and elevated levels may contribute to cell death mediated by this pathway. It also governs cell sensitivity to drugs that act directly on the proteasome. HDAC inhibitors influence proteasome activity and there may be a synergistic interaction with proteasome inhibitors. HR23B and HDAC6 interact and HDAC6 may be a negative regulator of apoptosis and a positive regulator of autophagy and through its ability to down-regulate HR23B, may impact on the cellular outcome of HDAC inhibitor treatment. Expression of HR23B has been correlated with clinical response to HDAC inhibitors in a retrospective analysis of CTCL patients. The tissue expression of HR23B and the autophagy marker LC3 has been investigated and there may be a reciprocal relationship in their expression in some tumours which may provide prognostic information and patients with low HR23B expression but high levels of autophagy appear to have a particularly poor prognosis. Well designed, biomarker-driven prospective clinical trials are needed to clarify the predictive and prognostic roles of HR23B.
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Ma, Yan M. Eng Massachusetts Institute of Technology. "Uganda Manafwa River early flood warning system development hydrologic watershed modeling using HEC-HMS, HEC-RAS, ArcGIS." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/82819.
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Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Civil and Environmental Engineering, 2013.Cataloged from PDF version of thesis.
Includes bibliographical references (p. 135-136).
The Manafwa River basin spans several districts in Eastern Uganda. Over the years, frequent floods have constantly posed a great threat to the local communities in these districts. The Uganda Red Cross Society (URCS) intends to design a precipitation based flood forecasting system for the Manafwa River Basin. Towards this end, the URCS initiated collaboration with MIT's Department of Civil and Environmental Engineering in January 2013, in an attempt to establish a hydrologic modeling system that relates upstream precipitation with downstream stream discharge using ArcGIS, HEC-HMS and HEC-RAS. This work is dedicated to present the progress in the modeling endeavor, provide technical guidance to the extent possible, and facilitate hydrologic modeling efforts of similar nature. The main focus is on the loss methods used in HEC-HMS: the Curve Number loss method and the Initial and Constant loss method It is found out that the neither the Curve Number nor Initial and Constant loss method is perfectly suitable to modeling both short-term and long term simulations. The Curve Number method is able to better model the precipitation-runoff processes in short term simulations. The Initial and Constant loss method tends to underestimate water volume runoff in short term simulations from what is observed The Curve Number loss method produced results that are on average closer to observed values in short term simulations; however, the resulting curve number values from calibration are considerably lower than the estimated values.
by Yan Ma.
M.Eng.
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Becker, Cristiane Miotto. "Estudo das propriedades mecânicas e antichamas de nanocompósitos HDL/epóxi e compósitos HDL/epóxi/fibra de vidro." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2011. http://hdl.handle.net/10183/56590.
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Os hidróxidos duplos lamelares (HDLs) são materiais que podem ser utilizados para modificar ou incorporar características a polímeros termoplásticos ou termorrígidos. O presente trabalho tem como objetivo a síntese e caracterização de HDLs de Mg-Al intercalados com os íons glicinato, alaninato e dodecil sulfato e a sua utilização na formulação de nanocompósitos bicomponente HDL/epóxi, com diferentes teores de HDL, produzidos por casting e de compósitos tricomponente HDL/epóxi/fibra de vidro moldados por RTM. Os HDLs foram sintetizados pelo método da coprecipitação e incorporados a epóxi com o auxílio de solventes e de ultrassom. Para tal, foram avaliados os solventes acetona, clorofórmio e DMF, sendo o DMF selecionado como o melhor agente de dispersão. Os compósitos e nanocompósitos obtidos foram caracterizados quanto à dispersão dos HDL na matriz, às suas propriedades de resistência à chama (teste horizontal e vertical), à estabilidade térmica, às propriedades mecânicas e dinâmico-mecânicas. A incorporação dos HDLs provocou um incremento na estabilidade térmica dos compósitos e todas as amostras com esta carga apresentaram comportamento autoextinguível no teste de queima vertical, além de apresentarem uma grande diminuição na taxa de queima em comparação ao epóxi puro. A utilização dos HDL não possibilitou melhora nas propriedades mecânicas e dinâmico-mecânicas dos compósitos, que só foi obtida com a utilização do reforço de fibra de vidro.Layered double hydroxides (LDHs) can be used to modify or incorporate characteristics into a variety of thermoplastic or thermoset polymers. The present work aims to synthesize and characterize Mg:Al LDHs intercalated with glycinate, alaninate and dodecyl sulfate and to use them in the formulation of bi-component LDH/epoxy nanocomposites, with distinct LDH content, obtained by casting, and tricomponent LDH/epoxy/glass fiber composites molded by RTM. The LDH was synthesized, using the coprecipitation method, and incorporated into epoxy with the aid of solvents and ultrasonication. For that, acetone, chloroform and DMF solvents were evaluated, and DMF yielded the best performance as dispersing agent. The obtained composites and nanocomposites were evaluated regarding the quality of the LDH dispersion in the matrix, their flame resistance characteristics (horizontal and vertical testing), thermal stability, mechanical and dynamic-mechanical properties. The incorporation of LDH caused an increase in thermal stability of the composites and all samples containing LDH showed self-extinguishing behavior in the vertical burning test, and a large decrease in the burning rate was found compared to neat epoxy. The use of LDH did not significantly alter the mechanical and dynamic-mechanical properties of the composites, which was only achieved by using a glass fiber reinforcement.
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Catalano, Giovanna. "Role of HDL particles in the reverse cholesterol transport pathway : a clinical need to evaluate HDL functionality." Paris 6, 2008. http://www.theses.fr/2008PA066420.
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Les taux de cholestérol-HDL (C-HDL) représentent un facteur de risque indépendant de maladie cardiovasculaire et des taux élèves de C-HDL sont corrélés à une diminution du risque cardiovasculaire. Dans le contexte du transport inverse du cholestérol, la sortie du cholestérol des cellules et la délivrance des esters de cholestérol au niveau hépatique représentent les étapes majeures impliquant les particules HDL. Au cours des dyslipidémies athérogènes les concentrations plasmatiques de C-HDL ainsi que la distribution du cholestérol au sein des sous populations de HDL sont altérés. La protéine clé impliquée dans le remodelage des HDL et le transport inverse du cholestérol est la protéine de transfert des esters de cholestérol (CETP). Ainsi l’inhibition de l’activité de la CETP pourrait corriger le profile lipidique anormal des dyslipidémies athérogènes associées à un phénotype C-HDL bas. Nous avons démontré que chez les sujets normolipidémiques les taux plasmatiques de C-HDL ne reflètent pas l’efficacité de l’étape initiale de la voie du transport inverse du cholestérol et que cette étape est sujette à des contraintes spécifiques liées au genre. De plus, nous avons démontré que chez de patients présentant une dyslipidémie de Type IIB associée à un phénotype C-HDL bas, l’inhibition de la CETP module différemment les fonctions biologiques des sous fractions HDL et restaure ainsi les étapes altérées de la voie du transport inverse du cholestérol.