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1

Sidorov, А. Yu, K. V. Fomina, and L. V. Beduleva. "HDL apoprotein immunization induces T cell-mediated venulitis and inflammation in aorta." Medical Immunology (Russia) 25, no. 3 (2023): 637–42. http://dx.doi.org/10.15789/1563-0625-hai-2699.

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The hypothesis that atherosclerotic processes are mostly caused by immune (autoimmune) mechanisms has recently been gaining attraction. At the same time, the autoimmune hypothesis of atherogenesis has not become generally accepted and requires additional evidence. Previously, we were able to induce changes in the aortic wall similar to those observed in the early stages of human atherosclerosis, and also to produce visceral obesity in normocholesterolaemic Wistar rats by a single immunization with human native high- or low-density lipoproteins. We also found that the immune response to native
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2

Aulia, Daradjatul, Sri Rahayu Lestari, and Yunita Rakhmawati. "Complementary Food to Improving HDL & LDL in Malnourished Male Wistar Strain White Rats." BIO Web of Conferences 117 (2024): 01012. http://dx.doi.org/10.1051/bioconf/202411701012.

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Protein-energy malnutrition (PEM) causes a decrease in amino acid synthesis, which affects the decrease in High-Density Lipoprotein (HDL) levels and an increase in Low-Density Lipoprotein (LDL) levels. Improving HDL and LDL levels in malnourished can be managed by providing Complementary Food (CF) with main ingredients such as banana flour, cassava flour, and corn flour. This study aims to describe the effect of CF supplementation on the HDL and LDL levels of malnourished male Wistar rats. The research method was experimental with a Randomized Block Design using twenty-four male rats. The expe
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3

Setyawati, Ika. "The Effects of Okra (Abelmoschus esculentus L.) Immersion Water on Changes in High-Density Lipoprotein and Low-Density Lipoprotein Levels in High Fat Diet Wistar Rat Model." Bioscientia Medicina : Journal of Biomedicine and Translational Research 6, no. 5 (2022): 1719–23. http://dx.doi.org/10.37275/bsm.v6i5.502.

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Background. The mortality rate due to cardiovascular disease increases; one of the effects of hypercholesterolemia conditions, dyslipidemia, hypertriglyceridemia, and metabolic syndrome, not handled properly and thoroughly. This phenomenon becomes the factor that the researchers took this research topic. This study aims to determine okra (Abelmoschus esculentus L.) immersion water on an increase in high density lipoprotein (HDL) levels and decrease in LDL (low density lipoprotein) levels in high fat diet model Wistar rats.
 Methods. This experimental study used 30 Wistar male rats (Rattus
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4

Muthmainah, Muthmainah, Ida Nurwati, Selfi Handayani, and Dyonisa Nasirochmi Pakha. "THE EFFECTIVENESS OF ETHANOL EXTRACT OF JAMBLANG LEAVES (Syzygium cumini L.) IN INCREASING HDL LEVELS IN WISTAR RATS MODELS OF METABOLIC SYNDROME." Jurnal Riset Kesehatan 12, no. 1 (2023): 8–15. http://dx.doi.org/10.31983/jrk.v12i1.9305.

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One of the characteristics of metabolic syndrome (MetS) is the low high-density lipoprotein (HDL) levels. Jamblang leaves (Syzygium cumini L.) contain various phytochemicals, which have antihyperglycemic, antihyperlipidemic, and antioxidant properties. This study aims to demonstrate the effectiveness of ethanol extract of jamblang leaves in increasing HDL levels in the Wistar rats model of MetS. A pretest-posttest with a control group design was conducted using 30 male Wistar rats, divided into five groups randomly, with six rats for each group. Here, KN means normal control group, K- negative
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Tenda, Priska Ernestina, and Eleonora Maryeta Toyo. "Anti-Cholesterolemic Activity of Mulberry (Morus australis Poir) Ethanol Extract in Increasing HDL Levels and Inhibiting Formation of Foam Cells on Rat." JURNAL INFO KESEHATAN 19, no. 1 (2021): 77–84. http://dx.doi.org/10.31965/infokes.vol19.iss1.497.

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Mulberry leaves are one of the medicinal plants empirically used by people to reduce cholesterol levels. Previous study found that mulberry leaves contain flavonoids, act as cholesterol-lowering and tannins function to inhibit the absorption of food, including fat in the GI tract. The objective of this study is to determine the effect of mulberry leaf ethanol extract on increased HDL levels and to determine the inhibition of the formation of foam cells in male Wistar strain rats given the atherogenic diet. Thirty male Wistar rats were divided into six groups, which were normal group, negative
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Feriohadi, Albashir, Esa Indah Ayudia, and Nyimas Natasha Ayu Shafira. "PENGARUH PEMBERIAN JUS BUAH TERONG PIRUS (Cyphomandra betacea cav Sendtn) TERHADAP KADAR HDL TIKUS PUTIH (Rattus norvegicus) GALUR Wistar YANG DIINDUKSI DIET TINGGI LEMAK." Journal of Medical Studies 2, no. 1 (2022): 13–25. http://dx.doi.org/10.22437/joms.v2i1.18089.

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 Tamarillo or tomato tree is rich in antioxidants that are useful for increasing blood HDL levels. This study aimed to determine the effect of tamarillo juice on blood HDL levels in white rats induced by a high-fat diet. The research design was True Experimental Pretest-Posttest Control Group Design. The research subjects were 28 male white rats of the Wistar strain which were divided into four groups. This study used tamarillo juice at doses of 75 mg/ml, 150 mg/ml, and 250 mg/ml. Blood HDL levels were checked on the 7th day, 21st day, and 47th day with a photometer. Data on bloo
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7

Godwin, Anyim, Oluwatoyin Oluwapelumi Agbetoye, Opeyemi Mutiu Adegoke, Adetoun Elizabeth Morakinyo, Bunmi Regina Elusiyan, and Bolajoko Ayinke Akinpelu. "The Effects of Asystasia vogeliana Benth. on Wistar Rat Liver Health, Kidney Function, and Lipid Profile." Asian Journal of Research in Biochemistry 13, no. 2 (2023): 17–27. http://dx.doi.org/10.9734/ajrb/2023/v13i2252.

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Aims: This study investigated the effects of long term consumption of A. vogeliana leaf on the liver health, kidney function, and lipid profile of female Wistar rats. This was with a view to assessing the safety and potential health effects of the plant extract.
 Study Design: The study employed in vivo animal model in Wistar rats.
 Place and Duration of Study: Department of Biochemistry and Molecular Biology, Obafemi Awolowo University, Ile-Ife, Nigeria, between June 2019 and February 2020.
 Methodology: Acute oral toxicity and LD50 were determined. Animals were randomized into
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8

Enwa, Felix Oghenemaro, Johnson Daniel Jemikalajah, Michael Oghenejobo, and Victor Eseoghene Oghenebrume. "Effect of methanol extract of Tridax procumbens flower on hematological parameters and serum lipid profiles of Wistar albino rats." Journal of Pharmacy & Bioresources 17, no. 1 (2020): 24–28. http://dx.doi.org/10.4314/jpb.v17i1.5.

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The aim of the study is to evaluate the effects of the methanolic extract of Tridax procumbens L. flower on the hematological and serum lipid profile of Albino Wistar rats. Ten male albino Wistar rats were obtained and divided into two groups (control and test). The flowers were extracted by cold maceration using methanol. The extract was then administered orally to the Test group at a dose of 100 mg/kg/d. Thereafter, blood samples were obtained from both groups and the hematological and serum lipid parameters were analyzed using auto-analyzers. The results of the hematological parameters obta
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9

Zsigmond, Eva, Bessie Fong, and Aubie Angel. "Characterization of high-density lipoprotein binding to rat adipocytes and adipocyte plasma membranes." Biochemistry and Cell Biology 66, no. 9 (1988): 986–97. http://dx.doi.org/10.1139/o88-113.

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The interaction of high-density lipoproteins (HDL) with adipocytes is important in the regulation of cellular cholesterol flux. To study the mechanisms of HDL binding and cellular processing, we incubated adipocytes isolated from epididymal and perirenal adipose tissue of male Wistar rats (300 g) with HDL1 (1.07–1.10 g/mL) and HDL2 (1.10–1.14 g/mL) fractions separated from rat plasma by gradient ultracentrifugation. Freshly isolated adipocytes were incubated with 125I-labeled HDL for 2 h at 37 °C to determine cell-associated uptake and degradation. Adipocytes from both fat regions showed signi
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10

Anwari, Ikhsan Syakban, and Hendra Sutysna. "The Effect of Olive Oil (Extra Virgine Olive Oil) and Moderate-Intensity Exercise On The Level of High Density Lipoprotein (HDL) in Male Wistar Strain Rat (Rattus novergicus L) Which Was Given High Fatty Diet." Muhammadiyah Medical Journal 1, no. 2 (2020): 69. http://dx.doi.org/10.24853/mmj.1.2.69-76.

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Background: Dyslipidemia is a condition where there is an abnormal lipid profile in the blood. Modern patterns and lifestyles such as consuming fast food cause excessive fat consumption which can increase the possibility of contracting blood vessel and heart disease. High levels of High Density Lipoprotein (HDL) cholesterol can protect the body against heart disease and stroke, but not many drugs can increase HDL cholesterol levels. Olive oil is an oil that contains 77% Mono Unsaturated Fatty Acid (MUFA) which can reduce LDL cholesterol and increase HDL cholesterol. Objective: To determine the
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11

Anwari, Ikhsan Syakban, and Hendra Sutysna. "The Effect of Olive Oil (Extra Virgine Olive Oil) and Moderate-Intensity Exercise On The Level of High Density Lipoprotein (HDL) in Male Wistar Strain Rat (Rattus novergicus L) Which Was Given High Fatty Diet." Muhammadiyah Medical Journal 1, no. 2 (2020): 27. http://dx.doi.org/10.24853/mmj.1.2.27-34.

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Background: Dyslipidemia is a condition where there is an abnormal lipid profile in the blood. Modern patterns and lifestyles such as consuming fast food cause excessive fat consumption which can increase the possibility of contracting blood vessel and heart disease. High levels of High Density Lipoprotein (HDL) cholesterol can protect the body against heart disease and stroke, but not many drugs can increase HDL cholesterol levels. Olive oil is an oil that contains 77% Mono Unsaturated Fatty Acid (MUFA) which can reduce LDL cholesterol and increase HDL cholesterol. Objective: To determine the
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12

Putriningtyas, Natalia Desy, Intan Permatasari, Dita Oktaviani, Anastasia Servia Raha, and Siti Wahyuningsih. "Red dragon fruit (Hylocereus spp.) peel marmalade effectively improve blood glucose and lipid profile of hypercholesterolemic wistar rats." Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) 9, no. 1 (2020): 61–67. http://dx.doi.org/10.14710/jgi.9.1.61-67.

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Background: Polyphenols, antioxidants, dietary fiber, and vitamin contained in the red dragon fruit peel. Red dragon fruit peel can be processed into marmalade. Red dragon fruit peel marmalade has the potential to be a functional food. Functional food is food that has a physiological function based on scientific studies.Objectives: The objective of this study is to analyze the effect of red dragon fruit peel marmalade on fasting blood glucose levels, HDL, LDL, and triglycerides levels of hypercholesterolemic Wistar rats.Methods: This study used a pre-&post-test control group design. Hyperc
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13

Barbalho, Sandra Maria, Ana Paula Machado Spada, Erick Prado de Oliveira, et al. "Mentha piperita effects on wistar rats plasma lipids." Brazilian Archives of Biology and Technology 52, no. 5 (2009): 1137–43. http://dx.doi.org/10.1590/s1516-89132009000500011.

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The aim of this study was to demonstrate the effects of Mentha piperita juice and tea on plasma lipids of Wistar rats. The animals were divided in control group (CG) and four treated groups: TG1 treated with tea and TG2 treated with juice (both receiving commercial rat chow); TG3 and TG4 were fed with supplemented fat chow (with hydrogenated fat and soybean oil) and treated respectively with tea and juice. Both tea and juice were administered by intra-gastric route (gavage) two times a day for 30 days. TG2 and TG4 animals showed significant decrease in triacylglycerols and increase in HDL-c le
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14

Fatoki, JO, OT Adedosu, AS Adekunle, OK Afolabi, and JA Badmus. "Toxicological Assessment of Scratch-off Foils from Prepaid Cards in Male Wistar Rat." Chemistry Research Journal 2, no. 3 (2017): 42–49. https://doi.org/10.5281/zenodo.13955006.

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Evaluation of toxic effects of the scratch-off foil on pre-paid cards are important because of the fingernails scratching of the card’s surface which lead to constant exposure to same by end users and retailers. Animals (n=18) were exposed to 10, 20 and 50 mg/kg body weight (b.w) foils from the cards three times a week for five weeks in corn oil through oral gavage while the control group (n=6) received corn oil only for the same period. Plasma and erythrocyte were analyzed for lipid dynamics and liver function tests. The results were analyzed using One-way ANOVA followed by Tukey’
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15

Velkovski, Sasko, Verica Milosevic, Snezana Ristic, Sladjan Pavlovic, Zorica Saicic, and Vesna Starcevic. "Effects of prolonged atherogenic diet on lipid status and some antioxidant parameters in rat blood." Jugoslovenska medicinska biohemija 21, no. 1 (2002): 31–36. http://dx.doi.org/10.2298/jmh0201031v.

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In this study we measured the effects of eight-week atherogenic diet on plasma lipid status, glutathione- S-transferase activity, red blood cells-catalase activity, and glutathione and vitamin E plasma level adult male Wistar albino rats. The animals were sacrificed by decapitation 24 h after the end of the diet. Triglycerides, total cholesterol, and LDL cholesterol plasma levels, as well as LDL/HDL ratio, and vitamin E plasma level significantly raised (p<0,05) after the diet in comparison with the controls. HDL cholesterol plasma level glutathione- -S-transferase and red blood cells-catal
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16

Mbegeze, Mussa B., Joan J. E. Munissi, Flora Stephano, Ramadhani S. O. Nondo, and Stephen S. Nyandoro. "Antidiabetic Potential of Vitex mombassae Fruits Extract in Streptozotocin-Nicotinamide Induced Diabetic Wistar Rat Model." Tanzania Journal of Science 49, no. 4 (2023): 776–87. http://dx.doi.org/10.4314/tjs.v49i4.1.

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Besides changes in life styles and improper dietary patterns, the rapidly increasing burden of diabetes mellitus type 2 is correlated with antidiabetic agents currently in clinical use, which are costly, less effective, and present undesirable side effects. Natural products from plants are promising alternative sources for developing more effective and cost friendly antidiabetic agents. This study therefore investigated the antidiabetic potential of Vitex mombassae fruits extract (VMFE) in streptozotocin-nicotinamide induced diabetic Wistar rat model. Oral acute toxicity test was conducted in
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17

Pinkey, Rawal, C. Ramesh, BA Sowmya, and CJ Ranjitha. "Determination of lipid lowering properties of methanol extract of Tephrosia villosa against high fat diet induced hyperlipidemia in wistar rats." Journal of Phytopharmacology 12, no. 4 (2023): 272–75. http://dx.doi.org/10.31254/phyto.2023.12410.

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Objectives: The present study was performed to determine hypolipidemic potentials of methanol extract of Tephrosia villosa against high fat diet induced hyperlipidemia in wistar rats. Methods: Defatted powdered drug of ariel parts of Tephrosia villosa was subjected to methanol extraction using soxhlet extractor. The high fat diet induced hyperlipidemia in rat model was used for the present investigation in which all experimental rats were ingested with high fat diet (HFD) for entire period of study and were also administered with methanol extract for 21 days. Blood samples were collected from
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18

Uba, Joy O., and Ogechukwu E. Ezim. "Effect of Aqueous Extract of Irvingia wombolu Seeds on Lipid Profile and Atherogenic Indices in Hyperlipidemic Wistar Rats." Asian Journal of Biochemistry, Genetics and Molecular Biology 16, no. 6 (2024): 9–18. http://dx.doi.org/10.9734/ajbgmb/2024/v16i6378.

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The effect of aqueous extract of Irvingia wombolu seeds on lipid profile and atherogenic indices in hyperlipidemic wistar rats was evaluated. Forty five (45) wistar rats were grouped into five groups of nine rats each. The animals were allowed seven days acclimatization period. Group one was the control group and it received normal rat chow and water throughout the study. Groups 2 to 5 were given high fat diet for 14 days after which they were fed with normal rat chow till the end of the study. At the end of the 14 days, group 2 was not treated while group 3-5 were treated with 250, 500 and 10
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19

Kitts, D. D., Y. V. Yuan, and D. V. Godin. "Plasma and lipoprotein lipid composition and hepatic antioxidant status in spontaneously hypertensive (SHR) and normotensive (WKY) rats." Canadian Journal of Physiology and Pharmacology 76, no. 2 (1998): 202–9. http://dx.doi.org/10.1139/y98-010.

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Plasma and lipoprotein lipid composition and endogenous hepatic antioxidant status were investigated in hypertensive, 14-week-old spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats fed a standard commercial rat chow. Total plasma calcium and magnesium concentrations were similar between both rat strains; however, systolic blood pressure in SHR was greater than in WKY at 13 weeks of age (197 ± 12 vs. 132 ± 14 mmHg; p <= 0.05), confirming hypertension in SHR. Total plasma cholesterol and triacylglycerol concentrations were lower (p <= 0.05) in SHR compared with WKY.
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20

Islahi, Annisa Nur, and Mulyati Mulyati. "Lipid Profile Of Wistar Rat (Rattus norvegicus Berkenhout, 1769) With Ulva lactuca L. Treatment." Metamorfosa: Journal of Biological Sciences 10, no. 2 (2023): 257. http://dx.doi.org/10.24843/metamorfosa.2023.v10.i02.p09.

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Lipid profile is an overview of lipids in the blood that can be used as an indicator of cardiovascular disorders. Changes in lipid metabolism can be caused by modification of lipid and lipoprotein that are correlated with free radical production. Free radicals can be induced by various things including heavy metal contamination. In a previous study, it was stated that heavy metals levels in Ulva lactuca L. originating from the coast in Gunung Kidul were above the threshold value by BPOM for vegetable foods. There was an attempt to decontaminate heavy metals in Ulva lactuca L. by immersing the
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21

Adeyemi, Oluyomi Stephen, and Bukola Temitope Orekoya. "Lipid Profile and Oxidative Stress Markers in Wistar Rats following Oral and Repeated Exposure to Fijk Herbal Mixture." Journal of Toxicology 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/876035.

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This study determined the effect of the oral and repeated administration of Fijk herbal mixture on rat biochemical and morphological parameters. Twenty-four Wistar rats were distributed into four groups of 6. Group A served as control and received oral administration of distilled water daily. The experimental groups B, C, and D were daily and orally exposed to Fijk herbal mixture at 15, 30, and 45 mg/kg, respectively. Treatments lasted for 21 days. The rats were sacrificed under mild diethyl ether anesthesia 24 hr after cessation of treatment. The blood and liver samples were collected and use
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22

Książek, Monika, Urszula Baranowska, Adrian Chabowski, and Marcin Baranowski. "Arteriovenous Sphingosine-1-Phosphate Differences Across Selected Organs of the Rat." Cellular Physiology and Biochemistry 45, no. 1 (2017): 67–77. http://dx.doi.org/10.1159/000486223.

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Background/Aims: Sphingosine-1-phosphate (S1P) is a bioactive lysosphingolipid that is found in high concentration in plasma. The majority of plasma S1P is transported bound to HDL and albumin. Although the major sources of circulating S1P have been identified, it remains obscure what is the contribution of different organs/tissues to S1P homeostasis in plasma. Answering this question was the major aim of the present study. Methods: The experiment was performed on male Wistar rats from whom blood samples were taken from either: 1) femoral vein, right ventricle of the heart, and abdominal aorta
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Jong, FX Himawan Haryanto, Ari Gunawan, Mochamad Wirono Aman Santoso, Susilowati Anjani, Ni Wayan Tirthaningsih, and Ahmad Basori. "Effects of Sambiloto Ethanol Extract on Fatty Liver, SGOT/SGPT Levels and Lipid Profile of Wistar Strain White Rat (Rattus norvegicus) Exposed to High-Fat Diet." Folia Medica Indonesiana 54, no. 2 (2018): 89. http://dx.doi.org/10.20473/fmi.v54i2.8856.

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The aim of this study was to analyze the effects of ethanol extract of sambiloto (Andrographis paniculata) on fatty liver percentage, serum glutamic oxaloacetic transaminase (SGOT) level and lipid profile of wistar strain white rat exposed to high fat diet. The study used randomized post test only control group design. Total sample was 50 male wistar strain rats (Rattus norvegicus) divided randomly into 5 groups (randomization). The normality test used was Kolmogorov Smirnov test (a=0.05). The homogeneity test used was Levene test (a=0.05). The comparative test was done using Anova test (analy
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24

Werdiningsih, Wiwik, and Suhartati Suhartati. "Effects of Red Pitaya (Hylocereus polyrhizus) on Lipid Profile of Male White Rats (Rattus norvegicus) Receiving High Fat Diet." Folia Medica Indonesiana 54, no. 1 (2018): 16. http://dx.doi.org/10.20473/fmi.v54i1.8046.

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Red dragon fruit (Hylocereus polyrhizus) peel contains anthocyanin, fiber and vitamin C, so it can be used to improve lipid profile in dyslipidemia. The peel of the dragon fruit is not durable, so in this study we used freeze-dried dragon fruit peel. The aim of this study was to prove that the administration of the red dragon fruit peel in a dose of 0.72 g/200 g BW, 1.08 g/200 g BW, and 1.44 g/200 g BW of rat per day for 28 days may improve lipid profile in male wistar strain white rats with high-fat diet. Lipid profiles were studied by examining of total cholesterol, LDL cholesterol, HDL chol
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Zsigmond, E., B. Fong, and A. Angel. "Proteolytic degradation of HDL1 on the fat cell surface is nutritionally regulated." Biochemistry and Cell Biology 67, no. 8 (1989): 428–33. http://dx.doi.org/10.1139/o89-068.

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The importance of plasma HDL apolipoprotein concentration as a predictor of atherosclerotic risk is well recognized, yet the processes of HDL modification and degradation in various cells are not clearly understood. We examined the characteristics of HDL1 apolipoprotein degradation and cellular uptake by rat adipocytes and determined the effects of fasting on these processes. Epididymal and perirenal adipocytes were isolated from male Wistar rats (310 ± 4 g) fed ad libidum and incubated with 5 μg of rat 125I-labeled HDL, (d: 1.07–1.10 g/mL) mL−1 for 2 h at 37 °C. Cellular uptake of HDL1 was ca
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Mohammadkhani, Reihaneh, Hamid Rajabi, Neda Khaledi, Alireza Komaki, and Iraj Salehi. "Effect of Maternal Training Before and During Pregnancy on the Lipid Profile in Wistar Rat Offspring." Jundishapur Journal of Medical Sciences 20, no. 5 (2021): 412–23. http://dx.doi.org/10.32598/jsmj.20.5.2131.

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Background and Objectives The fetal period is an important stage in a person’s life. Exercise during pregnancy has been considered as a positive factor in preventing chronic diseases in adulthood. The aim of this study was to investigate the role of maternal high intensity exercise before and during pregnancy on serum levels of lipid profile of adult offspring. Subjects and Methods Twenty-four rats (170-200g) were divided into three maternal groups: Control (C), exercise Before Pregnancy (BP) and exercise before and during pregnancy (BDP). Exercise performed before pregnancy for six weeks and
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27

Qazi, Sumayya, Mumtaz Ali Qureshi, Abroo Fatima Qazi, Amin Fahim, Ghulam Shah Nizamani, and Bakhtawar Qureshi. "EFFECTS OF L-CARNITINE THERAPY ON FAT AND GLUCOSE METABOLISM AMONG MELDONIUM INDUCED CARNITINE DEPLETION IN ALBINO WISTAR RATS." Pakistan Journal of Physiology 20, no. 1 (2024): 26–29. http://dx.doi.org/10.69656/pjp.v20i1.1610.

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Background: L-carnitine therapy has a potential role in lipid metabolism and glucose homeostasis. Despite its promising effects, further investigation is warranted. This study aimed to determine the impact of L-carnitine therapy of low and high doses on fat and glucose metabolism of albino Wistar rats after Meldonium induced carnitine depletion. Methods: A total number of 48 albino Wistar rats were recruited and divided into four groups 12 rats in each group. The bedding material was changed every second day and all animals were given Kaytee Supreme Fortified Daily Diet rat food and clean dist
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de Moura, Rodrigo Ferreira, Carla Ribeiro, Juliana Aparecida de Oliveira, Eliane Stevanato, and Maria Alice Rostom de Mello. "Metabolic syndrome signs in Wistar rats submitted to different high-fructose ingestion protocols." British Journal of Nutrition 101, no. 8 (2008): 1178–84. http://dx.doi.org/10.1017/s0007114508066774.

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In search of an adequate model for the human metabolic syndrome, the metabolic characteristics of Wistar rats were analysed after being submitted to different protocols of high fructose ingestion. First, two adult rat groups (aged 90 d) were studied: a control group (C1;n6) received regular rodent chow (Labina, Purina) and a fructose group (F1;n6) was fed on regular rodent chow. Fructose was administered as a 10 % solution in drinking water. Second, two adult rat groups (aged 90 d) were evaluated: a control group (C2;n6) was fed on a balanced diet (AIN-93G) and a fructose group (F2;n6) was fed
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Ojiako, Okey A., Paul C. Chikezie, Doris I. Ukairo, Chiedozie O. Ibegbulem, and Reginald N. Nwaoguikpe. "Functional assessments and histopathology of hepatorenal tissues of rats treated with raw and processed herbs." European Journal of Biological Research 7, no. 3 (2017): 172–90. https://doi.org/10.5281/zenodo.823220.

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The present study ascertained the functional integrity of hepatic and renal tissues, concurrently with blood lipid patterns, of Wistar rats infused with CCl<sub>4</sub> and treated with raw and hydrothermal processed herbs, namely, <em>Monodora myristica</em>, <em>Chromolaena odorata</em>, <em>Buccholzia coriacea</em> and <em>Sphenostylis stenocarpa</em>. Measurement of phytochemical contents of the herbs was according to standard methods. The rats were randomly designated on the bases of diets and treatments received for 28 consecutive days. Fibrosis was induced in the Wistar rats by single d
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Rosnah, Rosnah, Nurpudji A. Taslim, Andi Makbul Aman, et al. "The Formulation and Evaluation of High-Fat Pellet on Lipid Profiles and Body Mass Index of Male Wistar Rats." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 31, no. 1 (2022): 285–92. http://dx.doi.org/10.31351/vol31iss1pp285-292.

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This study aimed to explore the manufacture of high-fat pellets for obesity induction diets in male Wistar rats and determined its effect on lipid profiles and body mass index. It was an experimental laboratory method with a post-test randomized control group. Formulation of high-fat pellets (HFD) and physico-chemical characteristics of pellets were conducted in September 2019. This study used about 28 male Wistar white rats, two months old, and 150-200 g body weight. Rats were acclimatized for seven days, then divided into four groups: 7 rats were given a standard feed of Confeed PARS CP594 (
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Ayuningtyas, Annisa, Tri Winarni Agustini, and Kis Djamiatun. "Whiteleg shrimp shell powder ameliorates adiponectin and triglyceride-to-HDL ratio in type 2 diabetic rats." Nutrition & Food Science 50, no. 4 (2019): 617–29. http://dx.doi.org/10.1108/nfs-04-2019-0138.

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Purpose Adiponectin, a bioactive molecule produced by adipose tissue, has potential effect in increasing insulin sensitivity. Adiponectin levels reduction is associated with type 2 diabetes mellitus (T2DM) and its complications, including cardiovascular disease (CVD). Triglyceride-to-high-density lipoprotein (TG:HDL) ratio can be used as a predictor of CVD risk in T2DM patients. Whiteleg shrimp (Litopenaeus vannamei) shell contains astaxanthin, macro- and micro-nutrients that may exert synergistic beneficial effects. This study aims to determine the effect of L. vannamei shell powder (LVSP) in
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32

Pinkey Rawal, C. Ramesh, B. A. Sowmya, and C. J. Ranjitha. "Determination of Lipid Lowering Properties of Methanol Extract of Tephrosia villosaAgainst High Fat Diet Induced Hyperlipidemia in Wistar Rats." Journal of Pharmaceutical and Medicinal Research 8, no. 1 (2023): 141–43. http://dx.doi.org/10.30799/jpmr.061.23080101.

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The present study was performed to determine hypolipidemic potentials of methanol extract of Tephrosia villosa against high fat diet induced hyperlipidemia in wistar rats. Defatted powdered drug of ariel parts of Tephrosia villosa was subjected to methanol extraction using soxhlet extractor. The high fat diet induced hyperlipidemia in rat model was used for the present investigation in which all experimental rats were administered with single dose of triton (250mg/kg, ip.) on 1st day with methanol extract and upto 21 days. Blood samples were collected from all the animals on the 21stday after
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33

Zafar, Hamza, Noor ul Ain, Abdulrahman Alshammari, et al. "Lacticaseibacillus rhamnosus FM9 and Limosilactobacillus fermentum Y57 Are as Effective as Statins at Improving Blood Lipid Profile in High Cholesterol, High-Fat Diet Model in Male Wistar Rats." Nutrients 14, no. 8 (2022): 1654. http://dx.doi.org/10.3390/nu14081654.

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Elevated serum cholesterol is a major risk factor for coronary heart diseases. Some Lactobacillus strains with cholesterol-lowering potential have been isolated from artisanal food products. The purpose of this study was to isolate probiotic Lactobacillus strains from traditional yoghurt (dahi) and yogurt milk (lassi) and investigate the impact of these strains on the blood lipid profile and anti-obesity effect in a high cholesterol high fat diet model in Wistar rats. Eight candidate probiotic strains were chosen based on in vitro probiotic features and cholesterol reduction ability. By 16S rD
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Khodadadi, Iraj, Ali Heshmati, and Manoochehr Karami. "The impact of dietary feta cheese and butter on serum lipid profile and fatty acid composition in rat." Nutrition & Food Science 47, no. 6 (2017): 884–95. http://dx.doi.org/10.1108/nfs-03-2017-0037.

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Purpose Cardiovascular diseases (CVDs) are the most common causes of death worldwide. Diets rich in saturated and trans-fatty acids are nutritional risk factors that foster the development of CVDs. The aim of this experimental study was to investigate the effects of dietary feta cheese and butter on serum lipid profile and fatty acid composition. Design/methodology/approach In all, 24 Wistar rats (eight weeks old) were fed with balanced high fat diets (24 per cent fat) including canola (control group) and either cheese or butter (experimental groups) for eight weeks. At the end of the experime
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Emochone, Roy Yohanna, and Ejeh Yakubu Ojochenemi. "Sub-acute nephrotoxicity of ethanol fraction of Senna tora on Wistar Albino Rats." GSC Advanced Research and Reviews 16, no. 2 (2023): 145–57. https://doi.org/10.5281/zenodo.10612744.

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Plant materials as sources of medical compounds continue to play a dominant role in the maintenance of human health since antiquity. The present study was designed to ascertain the toxicity of ethanolic extract of&nbsp;<em>Senna tora</em>&nbsp;leaves on Wistar rats. A total of twenty (25) Wistar rats were distributed into 5 group of 5 animals each. Group I, received normal saline, group II received 100 mg/kg, group III received 200 mg/kg, group IV received 400 mg/kg, and group V received 800 mg/kg of&nbsp;<em>Senna tora</em>&nbsp;leaf fraction respectively. The treatments lasted for 28 days of
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Kusal, Abeywardena Kavindu, Thammitiyagodage Mayuri Geethanjalie, Warahakgoda Gedara Sarath Sisira Kumara, Alosius Thushari Nelka Munasinghe, and Liyanage Dona Ashanthi Menuka Arawwawala. "INVESTIGATION OF CHOLESTEROL AND BLOOD GLUCOSE-REDUCING PROPERTIES AND ACUTE TOXICITIES OF THE TEA PREPARED BY VERNONIA CINEREA L. USING WISTAR RAT ANIMAL MODEL AND QUANTIFICATION OF FLAVONOID AND PHENOLIC CONTENTS." Journal of Applied Biological Sciences 17, no. 3 (2023): 451–59. https://doi.org/10.71336/jabs.1241.

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According to Ayurvedic and folkloric medicine of Sri Lanka, tea prepared using dried leaf powder of Vernonia cinerea L. (S. Monarakudummbiya) has many therapeutic effects including blood glucose and cholesterol-reducing properties. The study investigate cholesterol and blood glucose-reducing properties and acute toxicities exerted by V. cinerea L tea and quantify the total phenolic and flavonoid content. Three months Wistar (20) rats were recruited for the study and divided randomly (n=10) into two groups. One group of rats was daily given tea prepared using the leaf powder of V. cinerea while
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Olukanni, Olumide David, Yewande O. Alagbe, Oreoluwa T. Akande, Adedayo T. Olukanni, Gbenga G. Daramola, and Oluyomi S. Adeyemi. "Natural honey reduced atherogenic and coronary risk indices in Wistar rats." Universa Medicina 39, no. 1 (2020): 3. http://dx.doi.org/10.18051/univmed.2020.v39.3-11.

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&lt;strong&gt;BACKGROUND&lt;/strong&gt;&lt;br /&gt;The biochemical mechanism underlying the nutraceutical effects of honey is poorly understood, thus making its functions more a matter of speculations. In this study, we investigated the effects of honey on the atherogenic and coronary risk indices in Wistar rats.&lt;br /&gt;&lt;br /&gt;&lt;strong&gt;METHODS&lt;/strong&gt;&lt;br /&gt;An experimental design comprising two groups of rats fed with normal rat chow but with the experimental group receiving 10% honey in water and the control group water alone, for five weeks. Blood samples were colle
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Kakis, G., A. Kuksis та W. C. Breckenridge. "Redistribution of cholesterol and β-sitosterol between Intralipid and rat plasma lipoproteins and red blood cells in vivo". Biochemistry and Cell Biology 66, № 12 (1988): 1312–21. http://dx.doi.org/10.1139/o88-152.

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Male Wistar rats were injected intravenously with 2 mL of Intralipid containing 7.5 × 105 counts per minute (cpm) [14C]cholesterol and 7.5 × 105 cpm β-[3H]sitosterol. Blood was withdrawn immediately and at 5, 10, 20, 60,120, and 1440 min after injection from different animals. Plasma and red cells were separated and washed by conventional centrifugation, while lipoprotein density classes corresponding to chylomicrons, very low (VLDL), low (LDL), and high density lipoproteins (HDL) were isolated by ultracentrifugation. Total lipid and sterol compositions were determined by thin-layer chromatogr
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Borkar, Sudarshan, and Swapnil Goyal. "Hesperidin & Apigenin Attenuates Diabetes & Lipid Levels in Experimentally Induced Diabetes Mellitus in Wistar Rats." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 15, no. 03 (2024): 1666–70. http://dx.doi.org/10.25258/ijpqa.15.3.87.

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The aim of the present investigation is to study the antidiabetic potential of Hesperidin and Apigenin in Diabetic rats. Wistar Albino rats of either sex (150 to 200 g) were purchased from the CPCSEA approved vendor New Delhi. A total of three animals were used, which received a single oral dose in 500 mg/kg, body weight of different flavonoids. Doses equivalent to 25 mg and 50 mg per kilogram body weight were calculated, and suspended in 1% w/v Tween 80 solutions for the experiment. For OGTT, Different doses of both flavonoids i.e. Hesperidin &amp; Apigenin were administered 60 min prior to o
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Simões, Fernanda Correia, Ruy Garcia Marques, Cristina Fajardo Diestel, et al. "Lipidic profile among rats submitted to total splenectomy isolated or combined with splenic autotransplant." Acta Cirurgica Brasileira 22, suppl 1 (2007): 46–51. http://dx.doi.org/10.1590/s0102-86502007000700010.

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PURPOSE: To evaluate the alterations on plasmatic lipids levels among rats submitted to total splenectomy isolated or combined with splenic autotransplant receiving standard chow during the postoperative period. METHODS: Thirty Wistar rats were divided into three groups: control (C) - sham-operated, total splenectomy - isolated (TS) or combined with splenic autotransplantation (SA). Since the postoperative period, all animals received standard rat chow manipulated in accordance to the American Institute of Nutrition Rodents Diets (1993). The plasmatic levels of total cholesterol (TC), triglyce
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Karta, I. Wayan, Burhannuddin Burhannuddin, and Felicia Kartawidjajaputra. "ANALYSIS OF PHYTOCHEMICAL SUBSTANCE AND THE EFFECT OF CANG SALAK TEA (CST) DIET TO LIPID PROFILE ON HYPERLIPIDEMIC RAT." JST (Jurnal Sains dan Teknologi) 10, no. 2 (2021): 239–51. http://dx.doi.org/10.23887/jst-undiksha.v10i2.39302.

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The bark of Sibetan snakefruit (Salacca zalacca) and sappan wood (Caesalpinia sappan L.) are combined into the product of Cang Salak Tea (CST). This tea is expected to be useful for diseases associated with dyslipidemia. The purpose of this study was to examine the secondary metabolites in CST and to determine the effect of CST treatment on the lipid profile of total cholesterol (TC), triglyceride (TG), HDL, and LDL level. Wistar rats were divided into three groups: control group (K), hyperlipidemic rats group given CST (P1), and hyperlipidemic rat group without CST treatment. Group P1 was giv
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Karta, I. Wayan, Burhannuddin Burhannuddin, and Felicia Kartawidjajaputra. "ANALYSIS OF PHYTOCHEMICAL SUBSTANCE AND THE EFFECT OF CANG SALAK TEA (CST) DIET TO LIPID PROFILE ON HYPERLIPIDEMIC RAT." JST (Jurnal Sains dan Teknologi) 10, no. 2 (2021): 239–51. http://dx.doi.org/10.23887/jstundiksha.v10i2.39302.

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The bark of Sibetan snakefruit (Salacca zalacca) and sappan wood (Caesalpinia sappan L.) are combined into the product of Cang Salak Tea (CST). This tea is expected to be useful for diseases associated with dyslipidemia. The purpose of this study was to examine the secondary metabolites in CST and to determine the effect of CST treatment on the lipid profile of total cholesterol (TC), triglyceride (TG), HDL, and LDL level. Wistar rats were divided into three groups: control group (K), hyperlipidemic rats group given CST (P1), and hyperlipidemic rat group without CST treatment. Group P1 was giv
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43

Onyenibe, Nwozo Sarah, Kasumu Titilayo Fowokemi, and Oyinloye Babatunji Emmanuel. "African Nutmeg (Monodora Myristica) Lowers Cholesterol and Modulates Lipid Peroxidation in Experimentally Induced Hypercholesterolemic Male Wistar Rats." International Journal of Biomedical Science 11, no. 2 (2015): 86–92. http://dx.doi.org/10.59566/ijbs.2015.11086.

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To evaluate the cholesterol lowering potential and protective ability of aqueous extract of Monodora myristica experimental hypercholesterolemic rats, a short-term study was conducted. Hypercholesterolemia was induced by administering cholesterol orally at a dose of 40 mg/kg/0.3 ml. Plant extracts 100 or 200 mg/kg body weight and Questran 0.26 g/kg were administered five times a week for eight weeks for amelioration. Hypolipidemic effects were evaluated by measuring total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerid
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Mashimo, Tomoji, Hiroshi Ogawa, Zong-Hu Cui, et al. "Comprehensive QTL analysis of serum cholesterol levels before and after a high-cholesterol diet in SHRSP." Physiological Genomics 30, no. 2 (2007): 95–101. http://dx.doi.org/10.1152/physiolgenomics.00211.2006.

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The stroke-prone spontaneously hypertensive rat (SHRSP) showed an exaggerated response to a high-fat, high-cholesterol (HFC) diet, and the resulting reactive hypercholesterolemia was suggested to exacerbate the atherogenic process in this rat. We thus performed a quantitative trait locus (QTL) analysis on the serum cholesterol level of SHRSP before and after the HFC diet, with the final goal being the identification of the genetic mechanisms of its reactive hypercholesterolemia. Three hundred fifty-eight F2 rats between SHRSP and Wistar-Kyoto rat were employed in the study. The serum cholester
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EHI-Omosun, MB, and GI EZE. "Effects of Aqueous Leaf Extract of Vernonia amygdalina on High-Fat Diet-Induced Injury in the Heart and Aorta of the Adult Wistar Rat." Journal of Phytopharmacology 12, no. 2 (2023): 93–99. http://dx.doi.org/10.31254/phyto.2023.12205.

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The aim of this study was to investigate the effects of aqueous leaf extract of Vernonia amygdalina in Wistar rats fed with high-fat diet. 30 adult Wistar rats weighing between 250g and 280g were randomly assigned into 5 groups of 6 rats per group. Group A rats were placed on rat food and water only. Group B rats received 1000mg/kg body weight / day (BWT/D) of margarine. Group C rats received 300mg/kg BWT/D of V. amygdalina. Group D rats received 1000mg/kg BWT/D of margarine and 150mg/kg BWT/D of V. amygdalina. Group E rats received 1000mg/kg BWT/D of margarine and 300mg/kg BWT/D of V. amygdal
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Bahrudin, Mochamad, Asra Al Fauzi, and Paulus Sugianto. "Effectiveness of Red Watermelon in Preventing Atherosclerosis Through the Role of Lipids, PCSK9, LOX-1, CD36, and ABCA1 in Wistar Rats." Current Issues in Molecular Biology 47, no. 6 (2025): 433. https://doi.org/10.3390/cimb47060433.

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Atherosclerosis is a chronic condition marked by lipid accumulation, inflammation, and endothelial dysfunction, leading to narrowed arteries and an increased risk of heart attacks and strokes. Key proteins involved in this process include PCSK9, LOX-1, ROS, CD36, and ABCA1. PCSK9 degrades LDL receptors, raising blood LDL levels, while LOX-1 and CD36 promote the uptake of oxidized LDL by macrophages, enhancing foam cell formation. ABCA1, on the other hand, facilitates cholesterol efflux to HDL, reducing atherosclerosis risk. Red watermelon (Citrullus lanatus), rich in lycopene, citrulline, and
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Ari-Agung, I. G. A., N. T. Suryadhi, N. A. Mantik, I. K. Suter, and I. B. G. Partama. "COMBINATION OF TEMPEH AND CARROT PREVENT ATHEROSCLEROSIS WISTAR RAT: Indicated by Increase of HDL and Total Antioxidant, Decrease LDL, F2-Isoprostan, and IL-6." Indonesia Journal of Biomedical Science 7, no. 1 (2013): 30–36. http://dx.doi.org/10.15562/ijbs.v7i1.111.

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Coronary heart disease (CHD) is the leading cause of death, either in developed and developing countries. The disease is stimulated by the present of atherosclerosis. This study aims to investigate supplementation of combined tempeh M-2 and carrot to prevent atherosclerosis wistar rat by increases HDL and TAC, decreases LDL, F2-Isoprostan, and IL-6. This was a true experimental study with the factorial completely randomized post-test only control group design.  variables such as KN (standard feeding / pellets (50 g / kg bw / day), KP: pig lubrication: pellets (1: 9) (50 g / kg bw / day),
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Andrade, R. J., M. I. Lucena, J. A. Gonzalez-Correa, C. Garcia-Arias, and P. Gonzalez-Santos. "Short-Term Effect of Various Doses of Cyclosporin A on Plasma Lipoproteins and its Distribution in Blood: An Experimental Study." Human & Experimental Toxicology 12, no. 2 (1993): 141–46. http://dx.doi.org/10.1177/096032719301200208.

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Hyperlipidaemia commonly develops in both transplant recipients and experimental animals receiving cyclosporin A (CsA). However, the threshold of CsA induced-changes on lipoproteins and the role of parenteral vehicle (cremophor) has not been defined. Male Wistar rats were classified into five groups of six animals each and received CsA in cremophor vehicle at doses of 5, 10 or 20 mg kg-1 d-1, s.c., vehicle alone or saline for 7 d. Blood was obtained 24 h after the last dose and plasma was analysed. Plasma very low density lipoprotein (VLDL), low density lipoprotein (LDL), and high density lipo
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Abu Bakar Sajak, A., A. Azlan, F. Abas, and H. Hamzah. "Nutritional composition, phytochemicals and acute toxicity of herbal mixture (lemon, apple cider, garlic, ginger and honey) in zebrafish embryo and Wistar rat." Food Research 4, S1 (2020): 196–204. http://dx.doi.org/10.26656/fr.2017.4(s1).s11.

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This study was aimed to provide the reference frame for the safe dose design of polyphenol-rich herbal mixture, which consist of lemon, apple cider, garlic, ginger and honey (PRM) for the future efficacy study. Prior to this, the nutritional composition was first conducted and the identification of metabolites that present in PRM was determined using proton nuclear magnetic resonance (1H-NMR) spectroscopy. The acute toxicity of the PRM was then evaluated in zebrafish embryo and Wistar rats following The Organisation for Economic Co-operation and Development (OECD) guidelines. The PRM nutrition
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Soltani, HamidReza, Alireza Vahidi, Mohammad Dehghan Tezerjani, Mohammad Javaherchian, and SeyedAli Shiryazdi. "Effect of Sumac (Rhus coriaria) Extract on Blood Lipid Profile in White Wistar Rat." Internal Medicine and Medical Investigation Journal 2, no. 3 (2017): 97. http://dx.doi.org/10.24200/imminv.v2i3.91.

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Background: Hyperlipidemia is one of the chronic diseases whose current solutions are the proper diet and chemical drugs. Evaluation of accessible medicinal plant recourses has an important role to prevent and treat the hyperlipidemia. The present study aimed to investigate the effect of sumac (Rhus coriaria) extract on blood lipid profile in white Wistar rat.Methods: This laboratory animal experiment was conducted on 21 white Wistar rats during four weeks. The research units divided into three groups separately were fed by normal diet, fatty diet without sumac extract and fatty diet with suma
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