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Journal articles on the topic 'HDL-apoA-I exchange'

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Published: 3 June 2025

Last updated: 31 July 2025

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1

Neufeld, Edward B., Masaki Sato, Scott M. Gordon, et al. "ApoA-I-Mediated Lipoprotein Remodeling Monitored with a Fluorescent Phospholipid." Biology 8, no. 3 (2019): 53. http://dx.doi.org/10.3390/biology8030053.

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We describe simple, sensitive and robust methods to monitor lipoprotein remodeling and cholesterol and apolipoprotein exchange, using fluorescent Lissamine Rhodamine B head-group tagged phosphatidylethanolamine (*PE) as a lipoprotein reference marker. Fluorescent Bodipy cholesterol (*Chol) and *PE directly incorporated into whole plasma lipoproteins in proportion to lipoprotein cholesterol and phospholipid mass, respectively. *Chol, but not *PE, passively exchanged between isolated plasma lipoproteins. Fluorescent apoA-I (*apoA-I) specifically bound to high-density lipoprotein (HDL) and remode

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2

Lai, Shao-Jui, Ryunosuke Ohkawa, Yuna Horiuchi, Tetsuo Kubota, and Minoru Tozuka. "Red blood cells participate in reverse cholesterol transport by mediating cholesterol efflux of high-density lipoprotein and apolipoprotein A-I from THP-1 macrophages." Biological Chemistry 400, no. 12 (2019): 1593–602. http://dx.doi.org/10.1515/hsz-2019-0244.

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Abstract High-density lipoprotein (HDL) plays a main role in reverse cholesterol transport (RCT), one of the most important functions for preventing atherosclerosis. Recent reports have shown that red blood cells (RBCs) can be associated with RCT, an interaction facilitated by albumin. However, the RCT function of RBCs has not been thoroughly elucidated. In this study, the RCT function of RBCs was assessed using cholesterol efflux capacity (CEC) assays, in which [3H]-labeled cholesterol-loaded human acute monocytic leukemia (THP-1) macrophages were incubated with RBCs as a cholesterol acceptor

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3

Gogonea, Valentin, Judith Peters, Gary S. Gerstenecker, et al. "Protein Backbone and Average Particle Dynamics in Reconstituted Discoidal and Spherical HDL Probed by Hydrogen Deuterium Exchange and Elastic Incoherent Neutron Scattering." Biomolecules 10, no. 1 (2020): 121. http://dx.doi.org/10.3390/biom10010121.

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Lipoproteins are supramolecular assemblies of proteins and lipids with dynamic characteristics critically linked to their biological functions as plasma lipid transporters and lipid exchangers. Among them, spherical high-density lipoproteins are the most abundant forms of high-density lipoprotein (HDL) in human plasma, active participants in reverse cholesterol transport, and associated with reduced development of atherosclerosis. Here, we employed elastic incoherent neutron scattering (EINS) and hydrogen-deuterium exchange mass spectrometry (HDX-MS) to determine the average particle dynamics

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4

Heier, Martin, Mark S. Borja, Cathrine Brunborg, et al. "Reduced HDL function in children and young adults with type 1 diabetes." Cardiovascular Diabetology 16, no. 1 (2017): 85. https://doi.org/10.1186/s12933-017-0570-2.

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<strong>Background: </strong>Patients with type 1 diabetes (T1D) are at increased risk of cardiovascular disease (CVD). Measures of high-density lipoprotein (HDL) function provide a better risk estimate for future CVD events than serum levels of HDL cholesterol. The objective of this study was to evaluate HDL function in T1D patients shortly after disease onset compared with healthy control subjects.<strong>Methods: </strong>Participants in the atherosclerosis and childhood diabetes study were examined at baseline and after 5 years. At baseline, the cohort included 293 T1D patients with a mean

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5

Bond, H. M., G. Morrone, S. Venuta, and K. E. Howell. "Characterization and purification of proteins which bind high-density lipoprotein. A putative cell-surface receptor." Biochemical Journal 279, no. 3 (1991): 633–41. http://dx.doi.org/10.1042/bj2790633.

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High-density lipoprotein (HDL) is shown by ligand blotting to bind membrane-associated polypeptides with sizes of 60, 100 and 210 kDa. Binding was concentration-dependent and competed by excess unlabelled HDL. All the major apolipoproteins of HDL, apoA-I, apoA-II and apoA-IV, bound independently. The 100 kDa and 210 kDa HDL-binding activities were purified from membranes of Hep3B tumour cells by ion-exchange chromatography and gel filtration. The binding activities at 100 kDa and 210 kDa co-purified. After treatment with disulphide-reducing reagent, the 210 kDa band was no longer present and a

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6

Borja, Mark S., Lei Zhao, Bradley Hammerson, et al. "HDL-apoA-I Exchange: Rapid Detection and Association with Atherosclerosis." PLoS ONE 8, no. 8 (2013): e71541. http://dx.doi.org/10.1371/journal.pone.0071541.

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7

Huang, Zhiping, Akihiro Inazu, Masa-aki Kawashiri, Atsushi Nohara, Toshinori Higashikata, and Hiroshi Mabuchi. "Dual effects on HDL metabolism by cholesteryl ester transfer protein inhibition in HepG2 cells." American Journal of Physiology-Endocrinology and Metabolism 284, no. 6 (2003): E1210—E1219. http://dx.doi.org/10.1152/ajpendo.00453.2002.

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Cholesteryl ester transfer protein (CETP) promotes reverse cholesterol transport via exchange of cholesteryl ester and triglyceride among lipoproteins. Here, we focused on HDL metabolism during inhibition of CETP expression by using CETP antisense oligodeoxynucleotides (ODNs) in HepG2 cells. CETP secretion was decreased by 70% in mRNA levels and by 52% in mass 20 h after ODNs against CETP were delivered to HepG2 cells. Furthermore, as a consequence of the downregulation of CETP, the expression of scavenger receptor class B type I (SR-BI), an HDL receptor, was also reduced by ∼50% in mRNA and p

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8

Borja, Mark S., Bradley Hammerson, Chongren Tang, et al. "Effects of niacin and omega-3 fatty acids on HDL-apolipoprotein A-I exchange in subjects with metabolic syndrome." PLOS ONE 19, no. 2 (2024): e0296052. http://dx.doi.org/10.1371/journal.pone.0296052.

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HDL-apolipoprotein A-I exchange (HAE) measures a functional property associated with HDL’s ability to mediate reverse cholesterol transport. HAE has been used to examine HDL function in case-control studies but not in studies of therapeutics that alter HDL particle composition. This study investigates whether niacin and omega-3 fatty acids induce measurable changes in HAE using a cohort of fifty-six subjects with metabolic syndrome (MetS) who were previously recruited to a double-blind trial where they were randomized to 16 weeks of treatment with dual placebo, extended-release niacin (ERN, 2g

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9

LUSA, Sari, Matti JAUHIAINEN, Jari METSO, Pentti SOMERHARJU, and Christian EHNHOLM. "The mechanism of human plasma phospholipid transfer protein-induced enlargement of high-density lipoprotein particles: evidence for particle fusion." Biochemical Journal 313, no. 1 (1996): 275–82. http://dx.doi.org/10.1042/bj3130275.

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1. Phospholipid transfer protein (PLTP) mediates conversion of high-density lipoprotein (HDL3) to large particles, with concomitant release of apolipoprotein A-I (apoA-I). To study the mechanisms involved in this conversion, reconstituted HDL (rHDL) particles containing either fluorescent pyrenylacyl cholesterol ester (PyrCE) in their core (PyrCE-rHDL) or pyrenylacyl phosphatidylcholine (PyrPC) in their surface lipid layer (PyrPC-rHDL) were prepared. Upon incubation with PLTP they behaved as native HDL3, in that their size increased considerably. 2. When PyrPC-rHDL was incubated with HDL3 in t

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10

Wang, Xunde, Laurel Mendelsohn, Lita Freeman, Boris Vaisman, Alan Remaley, and Gregory J. Kato. "Stimulation of Nitric Oxide Synthase Activity By Plasma Apolipoproteins: a Biomarker of Endothelial Function in Adults with Sickle Cell Disease." Blood 124, no. 21 (2014): 4015. http://dx.doi.org/10.1182/blood.v124.21.4015.4015.

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Abstract Nitric oxide (NO) plays a critical role in maintaining basal vascular tone and regulating blood flow. Many factors, including shear stress and endogenous ligands such as vascular endothelial growth factor (VEGF) and insulin-like growth factor-1 (IGF1), stimulate the activity of endothelial nitric oxide synthase (eNOS). We have developed a bioassay that measures stimulation of NOS activity by soluble factors in unfractionated human plasma in cultured human endothelial cells using a sensitive NOS activity assay with radiolabeled substrate. The addition of 1% human plasma to the culture

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Soupene, Eric, Sandra K. Larkin, and Frans A. Kuypers. "Featured Article: Depletion of HDL3 high density lipoprotein and altered functionality of HDL2 in blood from sickle cell patients." Experimental Biology and Medicine 242, no. 12 (2017): 1244–53. http://dx.doi.org/10.1177/1535370217706966.

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In sickle cell disease (SCD), alterations of cholesterol metabolism is in part related to abnormal levels and activity of plasma proteins such as lecithin cholesterol acyltransferase (LCAT), and apolipoprotein A-I (ApoA-I). In addition, the size distribution of ApoA-I high density lipoproteins (HDL) differs from normal blood. The ratio of the amount of HDL2 particle relative to the smaller higher density pre-β HDL (HDL3) particle was shifted toward HDL2. This lipoprotein imbalance is exacerbated during acute vaso-occlusive episodes (VOE) as the relative levels of HDL3 decrease. HDL3 deficiency

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12

Holub, Ashley, Amir Abdolahi, Xin Tu, Shaker Mousa, Michael Oda, and Robert Block. "The Effects of Aspirin in Combination with EPA and DHA on HDL Cholesterol and HDL-ApoA-I Exchange in Individuals with Type 2 Diabetes Mellitus." Journal of Clinical Lipidology 11, no. 3 (2017): 792–93. http://dx.doi.org/10.1016/j.jacl.2017.04.035.

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13

Ong, Carlos, Shumylla Bacha, Tomas Vaisar, and Mark S. Borja. "Abstract 227: Measuring HDL-apolipoprotein A-I Exchange By Subclass In Reconstituted And Human HDL." Arteriosclerosis, Thrombosis, and Vascular Biology 43, Suppl_1 (2023). http://dx.doi.org/10.1161/atvb.43.suppl_1.227.

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Objective: Levels of high density lipoprotein (HDL) are inversely associated with cardiovascular disease risk. HDL particles contain a diverse array of lipids, cholesterol, and proteins, and exist over a range of sizes ranging from about 8 nm to about 17 nm diameter, but it is not well understood how HDL size affects its function. In this study we examine the effect of HDL particle size on the rate of HDL-apolipoprotein A-I (apoA-I) exchange in reconstituted and human HDL particles. Method and Results: Reconstituted HDL particles were synthesized from 16:0-18:1n-9 PC, cholesterol, and recombin

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14

Borja, Mark S., Armen Phelps, and Michael N. Oda. "Abstract 387: HDL-apolipoprotein A-I Exchange Occurs in the Absence of HDL Particle Remodeling." Arteriosclerosis, Thrombosis, and Vascular Biology 37, suppl_1 (2017). http://dx.doi.org/10.1161/atvb.37.suppl_1.387.

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Objective: Apolipoprotein A-I (apoA-I) spontaneously exchanges between high-density lipoprotein (HDL)-bound and lipid-free states. This is a key event in reverse cholesterol transport, necessary for de novo HDL biogenesis. However, the mechanism of HDL-apoA-I exchange (HAE) is poorly understood. In this study, we test whether HDL remodeling is obligatory to HAE or an independent process. Method and Results: Recombinant human apoA-I modified with single cysteine mutations were expressed in bacteria and labeled with Alexa 488 and Alexa 647 fluorophores. ApoA-I Alexa647 was used to synthesize rHD

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15

Didichenko, Svetlana A., Elena Velkoska, Alexey V. Navdaev, et al. "Abstract 10220: CSL112 (Apolipoprotein A-I (human)) Infusion Rapidly Increases ApoA-I Exchange Rate via Specific Serum Amyloid-Poor HDL Sub-Populations When Administered to Patients Post Myocardial Infarction." Circulation 144, Suppl_1 (2021). http://dx.doi.org/10.1161/circ.144.suppl_1.10220.

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Background: Apolipoprotein A-I (apoA-I) exchange rate (AER) into plasma high density lipoprotein (HDL) may represent a cell-free measure of HDL function, and predict recurrent major adverse cardiovascular events post-acute myocardial infarction (AMI). Purpose: To characterise the effects of CSL112 (apoA-I (human)) on AER and the relationships with specific HDL subpopulations when administered in the 90-day high-risk period post AMI. Methods: Patients from the AEGIS-I (ApoA-I Event Reducing in Ischemic Syndromes I) study received either placebo, 2g or 6g CSL112 post AMI. The rate of apoA-I exch

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16

Borja, Mark S., Lorena G. Ortega-Guerrero, and Michael N. Oda. "Abstract 190: The Effect of Particle Size on Apolipoprotein A-I Exchange in Reconstituted and Human-derived High Density Lipoprotein Particles." Arteriosclerosis, Thrombosis, and Vascular Biology 36, suppl_1 (2016). http://dx.doi.org/10.1161/atvb.36.suppl_1.190.

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Objective: The ability of high density lipoprotein (HDL) to promote cholesterol efflux from ATP binding cassette transporter A1 (ABCA1) is inversely associated with HDL particle size. The exchangeability of HDL’s primary protein constituent, apolipoprotein A-I (apoA-I), is positively correlated with cholesterol efflux capacity. However, it is unknown whether HDL particle size similarly affects the exchangeability of apoA-I. In this study, we investigated the effect of HDL particle size on the exchangeability of apoA-I on reconstituted (rHDL) and human-derived plasma HDL (pHDL) particles. Metho

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17

Borja, Mark S., Bradley Hammerson, Olga V. Savinova, Gregory C. Shearer, and Michael N. Oda. "Abstract 111: HDL-apolipoprotein A-I Exchange Is Impaired in the Metabolic Syndrome." Arteriosclerosis, Thrombosis, and Vascular Biology 35, suppl_1 (2015). http://dx.doi.org/10.1161/atvb.35.suppl_1.111.

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Objective: Metabolic syndrome (MetSyn) is associated with a host of cardiovascular risk factors including increased waist circumference, triglycerides, blood pressure, fasting glucose, and reduced high density lipoprotein cholesterol (HDL-C). Changes in HDL function, especially the ability to participate in reverse cholesterol transport, are more indicative of the atheroprotective properties of HDL compared to HDL-C levels alone. In this study, we determine the association of HDL-apolipoproteinA-I (apoA-I) exchange, a measure of HDL remodeling/apoA-I exchange, with MetSyn and its individual co

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18

Budhathoki, Ram K., and Mark S. Borja. "Abstract 534: High-density Lipoprotein Particles Containing Lipids Bearing An Eicosapentaenoyl Moiety Exhibit Increased Rates Of HDL-apolipoprotein A-I Exchange." Arteriosclerosis, Thrombosis, and Vascular Biology 42, Suppl_1 (2022). http://dx.doi.org/10.1161/atvb.42.suppl_1.534.

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Objective: Eicosapentaenoic acid (EPA) is a polyunsaturated fatty acid associated with cardiovascular risk reduction and found in fatty fish, dietary supplements, and more recently, prescription drugs. EPA is incorporated into phospholipids which are transported through the body by lipoproteins, including high-density lipoprotein (HDL). HDL function can be measured from the HDL-apolipoprotein (apoA-I) exchange rate. We measured the rate of HDL-apoA-I exchange (HAE) on reconstituted HDL particles containing phospholipids bearing an eicosapentanoyl moiety to examine whether EPA is associated wit

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19

Borja, Mark S., Yumin He, Jacques Genest, and Michael N. Oda. "Abstract 222: HDL-ApoA-I Exchange Rate is Inversely Correlated With Coronary Artery Disease Stability." Arteriosclerosis, Thrombosis, and Vascular Biology 34, suppl_1 (2014). http://dx.doi.org/10.1161/atvb.34.suppl_1.222.

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Objective: The exchange of apolipoprotein A-I between lipid-associated and lipid-free states is a key step in reverse cholesterol transport and is representative of HDL’s functional status. Reduced HDL-apoA-I exchange (HAE) is associated with the presence of cardiovascular disease. To build on this observation, we investigated the hypothesis that HAE in a coronary artery disease-identified patient decreases with increased coronary artery disease instability. Method: HAE was measured by electron paramagnetic resonance spectroscopy (EPR), wherein nitroxide-labeled lipid-free apoA-I is introduced

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20

Nilsson, Oktawia, Mikaela Lindvall, Laura Obici, Simon Ekström, Jens O. Lagerstedt, and Rita Del Giudice. "Structure dynamics of ApoA-I amyloidogenic variants in small HDL increase their ability to mediate cholesterol efflux." Journal of Lipid Research, November 17, 2020, jlr.RA120000920. http://dx.doi.org/10.1194/jlr.ra120000920.

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Apolipoprotein A-I (ApoA-I) of high-density lipoprotein (HDL) is essential for the transportation of cholesterol between peripheral tissues and the liver. However, specific mutations in Apolipoprotein A-I (ApoA-I) of high-density lipoprotein (HDL) are responsible for a late-onset systemic amyloidosis, the pathological accumulation of protein fibrils in tissues and organs. Carriers of these mutations do not exhibit increased cardiovascular disease risk despite displaying reduced levels of ApoA-I/ HDL-cholesterol. To explain this paradox, we show that the HDL particle profile of patients carryin

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Okumura-Noji, Kuniko, Giorgio Cavigiolio, Rong Huang, et al. "Abstract 411: An Anion-Exchange Chromatography Isolated Subfraction of Mouse Apolipoprotein A-I Is Unable to Activate Cellular Cholesterol Release from Mouse Peritoneal Macrophage Foam Cells." Arteriosclerosis, Thrombosis, and Vascular Biology 32, suppl_1 (2012). http://dx.doi.org/10.1161/atvb.32.suppl_1.a411.

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Aim: Human and mouse plasma apoA-I separate on anion exchange chromatography (6M urea) in distinct subfractions. To investigate the nature of this diversity, we analyzed the protein subfractions by IEF and Urea-PAGE, and compared their ability to generate HDL in vitro. Methods: Human and mouse plasma HDLs were delipidated then applied to an DE52 ion-exchange column and eluted by 30-60mM Tris-HCl, pH7.80 containing 6M urea. Mouse, human, and recombinant apoA-Is were analyzed by IEF (Ettan IPGphor3) followed by CBB protein staining. Urea-PAGE analysis was performed with 14% acrylamide gel in 6M

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Zhang, Linda S., Huan Tao, Tiffany Pleasent та ін. "Abstract 208: Isolevuglandin, a Highly Reactive γ-ketoaldehyde Formed from the Isoprostane Pathway, Induces Deleterious Structural and Functional Consequences to High-density Lipoprotein". Arteriosclerosis, Thrombosis, and Vascular Biology 37, suppl_1 (2017). http://dx.doi.org/10.1161/atvb.37.suppl_1.208.

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Recent evidence suggest that cardiovascular disease (CVD) risk depends on levels of functional HDL particles, not HDL-cholesterol. In CVD, increased oxidative stress generates reactive lipid species that alter HDL function. Isolevuglandins (isoLGs), generated in parallel to isoprostanes, are extremely reactive to lysine residues of proteins and headgroups of phosphatidylethanolamine (PE). Importantly, IsoLG protein and PE adducts are elevated in atherosclerosis. Recently, our group observed a 42% reduction of atherosclerotic lesion size when salicylamine (SAM), a small molecule scavenger of re

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23

Neufeld, Edward B., Nicolas O. Francone, Gizem Yilmaz, et al. "Abstract 556: Lipoprotein Remodeling and Cholesterol Exchange Monitored Using Fluorescent Lipids and Proteins." Arteriosclerosis, Thrombosis, and Vascular Biology 37, suppl_1 (2017). http://dx.doi.org/10.1161/atvb.37.suppl_1.556.

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We developed a sensitive and robust in vitro method to monitor lipoprotein cholesterol and protein exchange and lipoprotein remodeling, using non-exchangeable fluorescent phosphatidylethanolamine (PE) as a lipoprotein marker. We applied this method to monitor the exchange of unesterified cholesterol (FC) and apoA-I among isolated human lipoproteins and synthetic lipoprotein-X (LpX). Fluorescent FC, but not PE, rapidly equilibrated between VLDL and HDL, and transferred almost entirely from VLDL or HDL to LDL. Fluorescent apoA-I bound specifically to HDL and remodeled fluorescent PE and FC-label

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Correa, Yubexi, Mathilde Ravel, Marie Imbert, et al. "Lipid exchange of apolipoprotein A‐I amyloidogenic variants in reconstituted high‐density lipoprotein with artificial membranes." Protein Science 33, no. 5 (2024). http://dx.doi.org/10.1002/pro.4987.

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AbstractHigh‐density lipoproteins (HDLs) are responsible for removing cholesterol from arterial walls, through a process known as reverse cholesterol transport. The main protein in HDL, apolipoprotein A‐I (ApoA‐I), is essential to this process, and changes in its sequence significantly alter HDL structure and functions. ApoA‐I amyloidogenic variants, associated with a particular hereditary degenerative disease, are particularly effective at facilitating cholesterol removal, thus protecting carriers from cardiovascular disease. Thus, it is conceivable that reconstituted HDL (rHDL) formulations

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May-Zhang, Linda S., Valery Yermalitsky, Keri A. Tallman, et al. "Abstract 510: 4-oxo-2-nonenal Adducts in HDL are Elevated in Familial Hypercholesterolemia: Identification of Modified Sites and Functional Consequences." Arteriosclerosis, Thrombosis, and Vascular Biology 39, Suppl_1 (2019). https://doi.org/10.1161/atvb.39.suppl_1.510.

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The lipid peroxidation product 4-oxo-2-nonenal (ONE) derived from n-6 polyunsaturated fatty acids and generated in parallel to 4-hydroxynonenal (HNE) is a highly reactive protein crosslinker. Crosslinking of proteins in high-density lipoprotein (HDL) by lipid peroxidation products causes HDL dysfunction and contributes to atherogenesis. While HNE is relatively well studied, the relevance of ONE in atherosclerosis and in modifying HDL has not been examined. We have reported that ONE crosslinked apoA-I on HDL at a concentration of less than 3 mol ONE per 10 mol apoA-I (0.3 eq), which is 100-fold

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Didichenko, Svetlana A., Elena Velkoska, Alexei V. Navdaev, et al. "CSL112 (Human Apolipoprotein A-I) Infusion Rapidly Increases APOA1 (Apolipoprotein A1) Exchange Rate via Specific Serum Amyloid-Poor HDL (High-Density Lipoprotein) Subpopulations When Administered to Patients Post–Myocardial Infarction." Arteriosclerosis, Thrombosis, and Vascular Biology, March 30, 2023. http://dx.doi.org/10.1161/atvbaha.122.318243.

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BACKGROUND: To characterize the effects of CSL112 (human APOA1 [apolipoprotein A1]) on the APOA1 exchange rate (AER) and the relationships with specific HDL (high-density lipoprotein) subpopulations when administered in the 90-day high-risk period post–acute myocardial infarction. METHODS: A subset of patients (n=50) from the AEGIS-I (ApoA-I Event Reducing in Ischemic Syndromes I) study received either placebo or CSL112 post–acute myocardial infarction. AER was measured in AEGIS-I plasma samples incubated with lipid-sensitive fluorescent APOA1 reporter. HDL particle size distribution was asses

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27

Dergunov, Alexander D., Dmitry Y. Litvinov, and Mikhail S. Vlasov. "Abstract 113: Phospholipid Physical State Determines the Efficiency of Cholesteryl Ester Transfer by Cholesteryl Ester Transfer Protein between Discoidal High Density Lipoproteins." Arteriosclerosis, Thrombosis, and Vascular Biology 35, suppl_1 (2015). http://dx.doi.org/10.1161/atvb.35.suppl_1.113.

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The transfer of cholesteryl ester by recombinant cholesteryl ester transfer protein (CETP) between reconstituted discoidal HDL was studied. Particles contained apolipoprotein A-I, unsaturated palmitoyllinoleoylphosphatidylcholine (PLPC), palmitoyloleoylphosphatidylcholine (POPC) or saturated dipalmitoylphosphatidylcholine (DPPC) and cholesteryl ester up to 3 mol% as cholesteryl 1-pyrenedecanoate (CPD) or cholesteryl laurate (CL) in donor and acceptor rHDL, respectively. The concentration dependencies of excimerization upward deviated from a linear dependence, being more curvilinear for DPPC. S

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Kingwell, B. A., E. Velkoska, S. Diditchenko, et al. "CSL112 (human apolipoprotein A-I) infusion rapidly increases apoA-I exchange rate (AER) when administered to patients post myocardial infarction." European Heart Journal 42, Supplement_1 (2021). http://dx.doi.org/10.1093/eurheartj/ehab724.1212.

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Abstract Background Cholesterol efflux capacity (CEC) measured using patient serum and cultured macrophages is considered a biomarker of high-density lipoprotein (HDL) functionality. This parameter is inversely related to incident cardiovascular events and declines in the days post-acute myocardial infarction (AMI). The apolipoprotein A-I (apoA-I) exchange rate (AER) may represent an alternative, clinically amenable cell-free measure of CEC, which has also been associated with incident cardiovascular events (1). Purpose To characterise the effects of human apoA-I (CSL112) infusion on AER over

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29

URUSKA, ALEKSANDRA, MAJA MIETKIEWSKA-DOLECKA, AGATA GRZELKA-WOZNIAK, et al. "486-P: Haptoglobin Phenotype and HDL Function in Adults with Type 1 Diabetes (Prospective InlipoDiab1 Study)." Diabetes 74, Supplement_1 (2025). https://doi.org/10.2337/db25-486-p.

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Introduction and Objective: People with type 1 diabetes (T1DM) have high HDL cholesterol. This not translate into a better cardiovascular (CVD) prognosis but rather reflect impaired HDL function. The antiatherosclerotic function of HDL is related to reverse cholesterol transport from macrophages in arterial walls (cholesterol efflux capacity-CEC). CEC is CVD risk factor. HDL dysfunction may be related to copy number variants in haptoglobin (Hp), a strong antioxidant. Hp 2-2 enhances dysfunctional ApoA-I and increases CVD risk. There are no prospective data about Hp and CEC in newly diagnosed T

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Stankov, Sylvia, Cecilia Vitali, Joseph Park, et al. "Abstract 121: Exploiting Natural Genetic Variation In The Human Triglyceride Regulator APOA5 To Understand Its Function." Arteriosclerosis, Thrombosis, and Vascular Biology 41, Suppl_1 (2021). http://dx.doi.org/10.1161/atvb.41.suppl_1.121.

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Plasma triglycerides (TGs) are an independent predictor of the risk for CAD, the leading cause of death worldwide. TGs are also positively associated with risk and severity of hyperTG-induced acute pancreatitis (HTG-AP). Current therapies are often insufficient in reducing extremely elevated TGs. We believe that apolipoprotein A-V (apoA-V, encoded by APOA5) can fill this unmet medical need. ApoA-V is a potent modulator of TG metabolism; it enhances lipoprotein lipase TG hydrolysis. We hypothesize that naturally occurring human APOA5 variants can inform ApoA-V function and identify novel ApoA-V

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