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1

Kanaev, Sergey, Ye Bykova, I. Akulova, et al. "RADIATION BOOST AFTER WHOLE-BREAST IRRADIATION: DOSIMETRIC COMPARISON OF HIGH DOSE RATE INTERSTITIAL BRACHYTHERAPY AND IRRADIATION WITH ELECTRONS." Problems in oncology 64, no. 3 (2018): 303–9. http://dx.doi.org/10.37469/0507-3758-2018-64-3-303-309.

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Purpose: dosimetric comparison of high dose rate interstitial brachytherapy (HDR) and irradiation with electrons for radiation boost after whole-breast irradiation. Material and methods: in 62 patients with рТ1N0М0-рТ2№М0 breast cancer we used HDR brachytherapy for delivering boost to tumor bed. In all cases insertion of plastic needles was performed under CT control with subsequent 3D planning. Pre-insertion CT were used for 3D planning of boost delivery with electrons. Results: Boost delivery with HDR brachytherapy had several important advantages when compared with boost with electrons. HDR
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2

Mitra, Devarati, Yaguang Pei, Ivan Buzurovic, et al. "Angiosarcoma of the Scalp and Face: A Dosimetric Comparison of HDR Surface Applicator Brachytherapy and VMAT." Sarcoma 2020 (August 25, 2020): 1–6. http://dx.doi.org/10.1155/2020/7615248.

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Purpose. Angiosarcoma of the face and scalp is a rare disease with high rates of recurrence. The optimal treatment approach is not well defined. This study presents a dosimetric comparison of high-dose-rate surface applicator (HDR-SA) brachytherapy to volumetric-modulated arc therapy (VMAT). Methods. Between 2011 and 2018, 12 patients with primary or recurrent angiosarcoma of the face or scalp were treated with HDR-SA brachytherapy using CT-based planning at our institution. For comparison, deliverable VMAT plans for each patient were generated, and dose distribution was compared to the delive
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3

Strom, Tobin Joel Crill, Alex Cruz, Nicholas Figura, et al. "Health-related quality of life changes due to high-dose rate brachytherapy, low-dose rate brachytherapy, or intensity-modulated radiation therapy for prostate cancer." Journal of Clinical Oncology 34, no. 2_suppl (2016): 72. http://dx.doi.org/10.1200/jco.2016.34.2_suppl.72.

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72 Background: To compare urinary, bowel, and sexual health-related quality of life (HRQOL) changes due to high-dose rate (HDR) brachytherapy, low-dose rate (LDR) brachytherapy, or intensity modulated radiation therapy (IMRT) monotherapy for prostate cancer. Methods: Between January 2002 and September 2013, 413 low-risk or favorable intermediate-risk prostate cancer patients were treated with HDR brachytherapy monotherapy to 2,700-2,800 cGy in two fractions (n=85), iodine-125 LDR brachytherapy monotherapy to 14,500 cGy in one fraction (n=249), or IMRT monotherapy to 7,400-8,100 cGy in 37-45 fr
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Crook, Juanita, Marina Marbán, and Deidre Batchelar. "HDR Prostate Brachytherapy." Seminars in Radiation Oncology 30, no. 1 (2020): 49–60. http://dx.doi.org/10.1016/j.semradonc.2019.08.003.

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5

Tyree, W. C., H. Cardenes, M. Randall, and L. Papiez. "High-dose-rate brachytherapy for vaginal cancer: Learning from treatment complications." International Journal of Gynecologic Cancer 12, no. 1 (2002): 27–31. http://dx.doi.org/10.1136/ijgc-00009577-200201000-00005.

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Abstract.Tyree WC, Cardenes H, Randall M, Papiez L. High-dose-rate brachytherapy for vaginal cancer: learning from treatment complications.Historically, early stage vaginal cancer has been treated with low-dose-rate (LDR) brachytherapy with or without external beam radiation therapy (EBRT). Complication rates have been low and treatment efficacious. Although high-dose-rate (HDR) brachytherapy has been used for cervical cancer in many countries for over a decade, only more recently has it been integrated into treatment plans for vaginal cancer. This paper describes three patients treated with H
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Revathi, Jakkula, G. Durga Prasad MD, and Gundavarapu V. Lakshmikeerthana. "COMPARATIVE STUDY OF CONFORMAL HDR BRACHYTHERAPY WITH ICRU POINTS DOSES AND TOXICITY ASSESSMENT." International Journal of Advanced Research 11, no. 02 (2023): 390–97. http://dx.doi.org/10.21474/ijar01/16263.

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Background: Toxicity assessment is done by comparing HDR brachytherapy with ICRU point doses. D2cc doses of OAR in HDR brachytherapy is slightly more than ICRU point doses. Objectives:The primary objective is volumetric dose assessment and toxicity comparison between ICRU point doses and HDR brachytherapy. Materials and Methods: It is a prospective comparative study. The total number of patients enrolled in the study is 20. After obtaining informed consent, then patients were enrolled in the study. All patients were diagnosed with H.P.E. positive squamous cell carcinoma of the Cervix from stag
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Hatcher, Jeremy, Adam Shulman, Claire Dempsey, et al. "Collaborative Model for International Telehealth: High Dose Rate Brachytherapy Training for Emerging Radiation Oncology Centers in Lower- and Middle-Income Countries." JCO Global Oncology 6, Supplement_1 (2020): 51–52. http://dx.doi.org/10.1200/go.20.47000.

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PURPOSE High dose rate (HDR) brachytherapy is a critical treatment modality—both palliative and curative—for gynecologic malignancies that significantly burden low- and middle-income countries (LMICs). Many of these countries currently have limited capacity to provide necessary brachytherapy treatment. To bridge this gap in LMICs in North Africa and the Middle East, nonprofits Rayos Contra Cancer and Radiating Hope evaluated the efficacy, cost, and feasibility of a pilot HDR brachytherapy continuing medical education curriculum to selected regional cancer centers via videoconferencing. METHODS
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8

Scott, Aba Anoa, Joel Yarney, Verna Vanderpuye, et al. "Outcomes of patients with cervical cancer treated with low- or high-dose rate brachytherapy after concurrent chemoradiation." International Journal of Gynecologic Cancer 31, no. 5 (2021): 670–78. http://dx.doi.org/10.1136/ijgc-2020-002120.

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ObjectiveThe majority of patients with cervical cancer in Ghana present with locally advanced disease. In October 2014, high-dose rate (HDR) brachytherapy was introduced at the National Center for Radiotherapy, Accra after years of using low-dose rate (LDR) brachytherapy. The aim of this study was to compare the treatment outcomes of patients treated with LDR versus HDR brachytherapy.MethodsPatients with cervical cancer treated from January 2008 to December 2017 were reviewed. Those with stage IB–IIIB who received chemoradiation plus brachytherapy were included in the study. Post-operative pat
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9

Adhikari, Kanchan P., Aarati Shah, Bibek Achraya, Ambuj Karn, and Sandhya Chapagain. "ACCEPTANCE TESTING, COMMISSIONING AND QUALITY ASSURANCE FOR A NUCLETRON 192IR HDR BRACHYTHERAPY AFTERLOADER AT NAMS, BIR HOSPITAL." Scientific World 12, no. 12 (2015): 85–88. http://dx.doi.org/10.3126/sw.v12i12.13604.

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To evaluate the accuracy of radiation dose delivered to the cancer patients by using HDR Brachytherapy and to know proposed methods for the initial source installation tests, acceptance testing and a quality assurance program are done on Nucletron MicroSelectron 192Ir HDR Brachytherapy Afterloader at NAMS, Bir Hospital. The observation of sweet spots (maximum dose distribution) by using well chamber (SI HDR 1000) and electrometer (SI CDX 2000). On the basis of the observed sweet spot, Air Kerma Strength of the source is determined. Beside this includes the conformation of step size, radioactiv
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10

Shahabaz, Amir, and Muhammad Afzal. "Implementation of High Dose Rate Brachytherapy in Cancer Treatment." Science Progress and Research 1, no. 3 (2021): 77–106. http://dx.doi.org/10.52152/spr/2021.121.

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A technique of radiation therapy delivery in which the radioactive sources are placed very close or even inside the target volume is called Brachytherapy (BT). Brachytherapy is a type of radiation therapy. It destroys cancer cells by making it hard for them to multiply. In this technique, a radiation source is placed directly into or near a tumour. High dose-rate brachytherapy is also known as HDR brachytherapy, or temporary brachytherapy. It is a type of internal radiotherapy. HDR was developed to reduce the risk of cancer recurrence while shortening the amount of time it takes to get radiati
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11

Khor, TH. "Brachytherapy – One Man’s Meat, A Personal Journey in Radiation Oncology." Annals of the Academy of Medicine, Singapore 34, no. 5 (2005): 399–404. http://dx.doi.org/10.47102/annals-acadmedsg.v34n5p399.

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The Lecture covers the author’s personal experience in brachytherapy in radiation oncology, beginning with low-dose rate (LDR) treatments using 226Ra “hot” sources, in the 1960s and early 1970s, through manual afterloading for treating gynaecological cancers with the same sources in the 1970s and 1980s, to high-dose rate (HDR) remote afterloading on a microSelectron HDR machine, from 1989 on. This progression in brachytherapy is discussed, and specific applications to various tumour sites are presented, including long-term results of a personal series of 106 patients with cancer of the uterine
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12

Anindya, Mukherjee* Niladri B. Patra Kazi S. Manir Shyamal Kr. Sarkar. "A PROSPECTIVE CLINICAL STUDY ON THE BENEFIT OF ADDING CHEMOTHERAPY TO BRACHYTHERAPY IN PATIENTS WITH INCOMPLETE RESPONSE TO EXTERNAL BEAM IRRADIATION WITH CONCURRENT CHEMOTHERAPY IN LOCALLY ADVANCED CASES OF CARCINOMA CERVIX." Indian Journal of Medical Research and Pharmaceutical Sciences 3, no. 7 (2016): 9–19. https://doi.org/10.5281/zenodo.58115.

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<strong>Introduction</strong>: Concurrent chemoradiation followed by brachytherapy is the standard treatment of carcinoma cervix by radiotherapy. Efficient brachytherapy is all the more important in Indian scenario where bulky residual disease is mostly found after external radiotherapy. Our study investigates the feasibility and tolerability of High Dose Rate Brachytherapy (HDR-BT) combined with concurrent cisplatin against HDR-BT alone which is considered the traditional standard of care. <strong>Materials and Methods</strong>: Carcinoma cervix patients who have undergone &lsquo;partial resp
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13

Ahmad, N., H. Mahmood, and S. R. A. Jafri. "QUALITY ASSURANCE OF VARI-SOURCE HIGH DOSE RATE (HDR) BRACHYTHERAPY- REMOTE AFTER LOADER AND COST EFFECTIVENESS OF VARI-SOURCE HDR- BRACHYTHERAPY: NORI, ISLAMABAD EXPERIENCE." Nucleus 41, no. 1-4 (2020): 35–40. https://doi.org/10.71330/nucleus.41.01-4.1067.

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A quality control of Vari-Source high dose rate (HDR) remote after loading brachytherapy machine was carried out and the cost effectiveness of HDR brachytherapy machine was also evaluated considering the cost of ten Iridium-192 wire sources at Nuclear Medicine, Oncology and Radiotherapy Institute (NORI), Islamabad, Pakistan. A total number of 253 intracavitary insertions were done in 98 patients from October 1996 to May 2001. The results of the quality control tests performed during 1996 to 2001 were within the acceptable limits. The cost effectiveness of Vari-Source HDR brachytherapy machine
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14

Kabacińska, R., J. Jastrzembski, R. Makarewicz, and B. Drzewiecka. "Optimisation in HDR brachytherapy." Reports of Practical Oncology 2, no. 2 (1997): 44. http://dx.doi.org/10.1016/s1428-2267(97)70122-4.

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15

de la Torre, Marcela, Isabel Rodriguez, and Victor J. Bourel. "117 HDR endobronchial brachytherapy." Radiotherapy and Oncology 39 (May 1996): S30. http://dx.doi.org/10.1016/0167-8140(96)87922-9.

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16

Sharman, E. C. "A critical evaluation of the clinical value of high-dose rate brachytherapy in the treatment of prostate cancer." Journal of Radiotherapy in Practice 5, no. 4 (2006): 227–32. http://dx.doi.org/10.1017/s146039690600032x.

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Prostate cancer has been treated with low-dose rate (LDR) brachytherapy for early localised disease in the form of permanent seed implants, with all its inherent problems in terms of dosimetry and seed migration. High-dose rate (HDR) brachytherapy has mainly been utilised as a boost to external beam radiotherapy (EBRT) in patients with locally advanced disease. However, limited studies investigating HDR as a monotherapy for early local disease are yielding promising results in terms of biochemical control and reduced toxicity. With the ability to optimise the plan and conform the dose, dose es
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17

Annamalai, Manikandan, Laviraj MA, Haresh Kunhiparambath, et al. "Combined HDR brachytherapy boost plus external beam radiotherapy by IMRT versus external beam radiotherapy alone IMRT in intermediate- and high-risk prostate cancer: Dosimetric analysis from a randomized control trial." Journal of Clinical Oncology 33, no. 7_suppl (2015): 134. http://dx.doi.org/10.1200/jco.2015.33.7_suppl.134.

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134 Background: Dose escalation by IMRT or brachytherapy significantly improves biochemical control in localized prostate cancer. In this prospective randomized study we compared dose conformity between two modalities HDR brachytherapy and IMRT to deliver a boost to the prostate after External beam Radiotherapy (EBRT). Methods: 20 patients with localized prostate cancer were randomized to receive IMRT alone or IMRT plus brachytherapy. After randomization, all patients received EBRT 45Gy/25#/5 weeks by IMRT in phase I. In phase II patients received either HDR brachytherapy 19Gy/2# (Arm A) or EB
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18

Keyes, Mira, Juanita Crook, W. James Morris, et al. "Canadian Prostate Brachytherapy in 2012." Canadian Urological Association Journal 7, no. 1-2 (2013): 51. http://dx.doi.org/10.5489/cuaj.218.

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Prostate brachytherapy can be used as a monotherapy for low- and intermediate-risk patients or in combination with external beam radiation therapy (EBRT) as a form of dose escalation for selected intermediate- and high-risk patients. Prostate brachytherapy with either permanent implants (low dose rate [LDR]) or temporary implants (high dose rate [HDR]) is emerging as the most effective radiation treatment for prostate cancer. Several large Canadian brachytherapy programs were established in the mid- to late-1990s. Prostate brachytherapy is offered in British Columbia, Alberta, Manitoba, Ontari
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19

Wallace, Jordan, Maximilian Hanlon, Ryan L. Smith, and Rick Franich. "Dosimetric Evaluation of an Adaptive Planning Strategy for Implant Shift in HDR Prostate Brachytherapy." Journal of Physics: Conference Series 2799, no. 1 (2024): 012018. http://dx.doi.org/10.1088/1742-6596/2799/1/012018.

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Abstract The occurrence of significant implant shifts between CT simulation planning and first fraction delivery is a frequent challenge for HDR prostate brachytherapy treatment. Here, we present evidence supporting the viability of a first-order adaptation strategy as a viable alternative to the conventional practice of re-scanning and re-planning. Our findings underscore the potential of this approach to enhance workflow efficiency in HDR prostate brachytherapy.
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Nag, S., R. Martínez-Monge, F. Ruymann, A. Jamil, and C. Bauer. "Innovation in the management of soft tissue sarcomas in infants and young children: high-dose-rate brachytherapy." Journal of Clinical Oncology 15, no. 9 (1997): 3075–84. http://dx.doi.org/10.1200/jco.1997.15.9.3075.

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PURPOSE Conventional low-dose-rate (LDR) brachytherapy is effective in treating childhood sarcomas, but often not practical (due to the associated radiation hazards) in the young children who require continuous observation and sedation. Fractionated high-dose-rate brachytherapy (HDR) was used to deliver adequate tumoricidal radiation while preserving bone and organ growth in children. MATERIALS AND METHODS Twelve children with diverse sarcomas were treated with fractionated HDR. The median age at diagnosis was 18 months (range, 1 to 42). Nine patients had rhabdomyosarcoma and three had other s
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21

Deepak Sharma, Amrut S Kadam, Ramashish Kumar, et al. "Assessment of dose contribution to pelvic lymph nodes in patients undergoing brachytherapy for carcinoma cervix." Asian Journal of Medical Sciences 15, no. 12 (2024): 176–80. https://doi.org/10.71152/ajms.v15i12.4305.

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Background: The inclusion of pelvic lymph node (PLN) metastasis in the FIGO staging system has impacted disease classification and patient survival. Brachytherapy is a key component in managing carcinoma cervix; however, the dose contribution of brachytherapy to PLNs remains unclear. Aims and Objectives: This study aims to quantify the dose contribution of high-dose rate (HDR) brachytherapy to individual pelvic nodal groups. Materials and Methods: We included 40 biopsy-proven carcinoma cervix patients, stages IIA to IVA. All patients underwent external beam radiotherapy (EBRT) with concurrent
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Deepak Sharma, Amrut S Kadam, Ramashish Kumar, et al. "Assessment of dose contribution to pelvic lymph nodes in patients undergoing brachytherapy for carcinoma cervix." Asian Journal of Medical Sciences 15, no. 12 (2024): 176–80. https://doi.org/10.3126/ajms.v15i12.69957.

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Background: The inclusion of pelvic lymph node (PLN) metastasis in the FIGO staging system has impacted disease classification and patient survival. Brachytherapy is a key component in managing carcinoma cervix; however, the dose contribution of brachytherapy to PLNs remains unclear. Aims and Objectives: This study aims to quantify the dose contribution of high-dose rate (HDR) brachytherapy to individual pelvic nodal groups. Materials and Methods: We included 40 biopsy-proven carcinoma cervix patients, stages IIA to IVA. All patients underwent external beam radiotherapy (EBRT) with concurrent
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23

Chin, Joseph, R. Bryan Rumble, Marisa Kollmeier, et al. "Brachytherapy for Patients With Prostate Cancer: American Society of Clinical Oncology/Cancer Care Ontario Joint Guideline Update." Journal of Clinical Oncology 35, no. 15 (2017): 1737–43. http://dx.doi.org/10.1200/jco.2016.72.0466.

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Purpose To jointly update the Cancer Care Ontario guideline on brachytherapy for patients with prostate cancer to account for new evidence. Methods An Update Panel conducted a targeted systematic literature review and identified more recent randomized controlled trials comparing dose-escalated external beam radiation therapy (EBRT) with brachytherapy in men with prostate cancer. Results Five randomized controlled trials provided the evidence for this update. Recommendations For patients with low-risk prostate cancer who require or choose active treatment, low–dose rate brachytherapy (LDR) alon
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Kolotas, Christos, D. Baltas, B. Rome, T. Martin, and N. Zarnboolou. "118CT based interstitial HDR brachytherapy." Radiotherapy and Oncology 47 (May 1998): S30. http://dx.doi.org/10.1016/s0167-8140(98)80123-0.

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25

Feuillade, J., M. Gautier, C. Dejean, A. Mana, J. M. Hannoun–Levi, and S. Marcie. "New radioisotopes HDR brachytherapy dose." Physica Medica 30 (December 2014): e138-e139. http://dx.doi.org/10.1016/j.ejmp.2014.10.057.

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Kolotas, Christos, Dimos Baltas, and Nikolaos Zamboglou. "CT-Based Interstitial HDR Brachytherapy." Strahlentherapie und Onkologie 175, no. 9 (1999): 419–27. http://dx.doi.org/10.1007/s000660050031.

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27

Piro, Fabrizio. "HDR brachytherapy for skin cancers." Brachytherapy 7, no. 2 (2008): 128. http://dx.doi.org/10.1016/j.brachy.2008.02.111.

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28

Medina, Rogelio, Luke Macyszyn, Andrew S. Lim, et al. "High-Dose Rate Interstitial Spine Brachytherapy Using an Intraoperative Mobile Computed Tomography-Guided Surgical Navigation System." Operative Neurosurgery 21, no. 6 (2021): 507–15. http://dx.doi.org/10.1093/ons/opab328.

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Abstract BACKGROUND Up to 15% of previously irradiated metastatic spine tumors will progress. Re-irradiation of these tumors poses a significant risk of exceeding the radiation tolerance to the spinal cord. High-dose rate (HDR) brachytherapy is a treatment alternative. OBJECTIVE To develop a novel HDR spine brachytherapy technique using an intraoperative computed tomography-guided navigation (iCT navigation). METHODS Patients with progressive metastatic spine tumors were included in the study. HDR brachytherapy catheters were placed under iCT navigation. CT-based planning with magnetic resonan
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29

Li, Hualei, Mindi J. TenNapel, Amina Ahmed, Lilie Lin, Sudershan K. Bhatia, and Geraldine Jacobson. "Uterine Carcinosarcoma Confined to the Pelvis: A Retrospective Review and Outcome Analysis." Journal of Radiotherapy 2014 (March 11, 2014): 1–8. http://dx.doi.org/10.1155/2014/124149.

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Objective. We compared the treatments of uterine carcinosarcoma at our institution and evaluated their impact on survival. Methods. A retrospective analysis was performed on 60 eligible patients with carcinosarcoma limited to the pelvis. Subjects were divided into four categories: surgery, surgery plus chemotherapy, surgery plus radiation therapy, and a combination of surgery, chemotherapy, and RT. The most commonly used chemotherapy was cisplatin and/or carboplatin and taxol. Radiotherapy included external beam radiation therapy (EBRT) alone or with high dose rate (HDR) brachytherapy or HDR b
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Goyal, Manish K., T. S. Kehwar, Jayanand Manjhi, et al. "Dosimetric evaluation of tandem-based cervical high-dose-rate brachytherapy treatment planning using American Brachytherapy Society 2011 recommendations." Journal of Radiotherapy in Practice 15, no. 3 (2016): 283–89. http://dx.doi.org/10.1017/s1460396916000133.

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AbstractPurposeThis study evaluated dosimetric parameters for cervical high-dose-rate (HDR) brachytherapy treatment using varying dose prescription methods.MethodsThis study includes 125 tandem-based cervical HDR brachytherapy treatment plans of 25 patients who received HDR brachytherapy. Delineation of high-risk clinical target volumes (HR-CTVs) and organ at risk were done on original computed tomographic images. The dose prescription point was defined as per International Commission in Radiation Units and Measurements Report Number 38 (ICRU-38), also redefined using American Brachytherapy So
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Kandasamy, Saravanan, K. S. Reddy, Vivekanandan Nagarajan, Parthasarathy Vedasoundaram, and Gunaseelan Karunanidhi. "Inter-fraction variation in interstitial high-dose-rate brachytherapy." Journal of Radiotherapy in Practice 14, no. 2 (2015): 143–51. http://dx.doi.org/10.1017/s1460396915000047.

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AbstractAimTo evaluate the inter-fraction variation in interstitial high-dose-rate (HDR) brachytherapy. To assess the positional displacement of catheters during the fractions and the resultant impact on dosimetry.BackgroundAlthough brachytherapy continues to be a key cornerstone of cancer care, it is clear that treatment innovations are needed to build on this success and ensure that brachytherapy continues to provide quality care for patients. The dosimetric advantages offered by HDR brachytherapy to the tumour volume rely on catheter positions being accurately reproduced for all fractions o
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Yang, Xiaofeng, Peter J. Rossi, Ashesh B. Jani, et al. "Improved prostate delineation in prostate HDR brachytherapy with TRUS‐CT deformable registration technology: A pilot study with MRI validation." Journal of Applied Clinical Medical Physics 18, no. 1 (2017): 202–10. http://dx.doi.org/10.1002/acm2.12040.

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AbstractAccurate prostate delineation is essential to ensure proper target coverage and normal‐tissue sparing in prostate HDR brachytherapy. We have developed a prostate HDR brachytherapy technology that integrates intraoperative TRUS‐based prostate contour into HDR treatment planning through TRUS‐CT deformable registration (TCDR) to improve prostate contour accuracy. In a perspective study of 16 patients, we investigated the clinical feasibility as well as the performance of this TCDR‐based HDR approach. We compared the performance of the TCDR‐based approach with the conventional CT‐based HDR
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Gogia, Pooja, Anil Dhull, and Vivek Kaushal. "Weekly versus biweekly high-dose rate brachytherapy schedules in carcinoma cervix following concomitant chemoradiation with paclitaxel and carboplatin." Asian Journal of Oncology 03, no. 01 (2017): 012–16. http://dx.doi.org/10.4103/asjo.asjo_111_16.

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Abstract Context: In the management of cervical cancer, though a number of chemotherapeutic drugs have been used for concomitant chemoradiation, paclitaxel and carboplatin have shown improved overall response rates with acceptable side effects. The use of intracavitary irradiation significantly improves survival and reduces local failures. However, the ideal time-dose-fraction schedule remains controversial with high-dose rate (HDR) brachytherapy. Aims: The aim of this study was to determine the efficacy and safety of paclitaxel and carboplatin for concomitant chemoradiation therapy and to com
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34

Wang, Li, Yao Ding, Teresa L. Bruno, et al. "A Novel Positive-Contrast Magnetic Resonance Imaging Line Marker for High-Dose-Rate (HDR) MRI-Assisted Radiosurgery (MARS)." Cancers 16, no. 10 (2024): 1922. http://dx.doi.org/10.3390/cancers16101922.

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Magnetic resonance imaging (MRI) can facilitate accurate organ delineation and optimal dose distributions in high-dose-rate (HDR) MRI-Assisted Radiosurgery (MARS). Its use for this purpose has been limited by the lack of positive-contrast MRI markers that can clearly delineate the lumen of the HDR applicator and precisely show the path of the HDR source on T1- and T2-weighted MRI sequences. We investigated a novel MRI positive-contrast HDR brachytherapy or interventional radiotherapy line marker, C4:S, consisting of C4 (visible on T1-weighted images) complexed with saline. Longitudinal relaxat
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Guerif, Stephane Gilles, Ossama Didas, Jean Pierre Tasu, et al. "Multimodal image and mapping guided focal salvage high-dose-rate brachytherapy for local recurrent prostate cancer." Journal of Clinical Oncology 35, no. 6_suppl (2017): 122. http://dx.doi.org/10.1200/jco.2017.35.6_suppl.122.

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122 Background: Image guided brachytherapy and mapping biopsy could reduce the toxicity of the total salvage brachytherapy. This study evaluate the tumor control and the tolerance of a focal real time salvage high-dose-rate (HDR) brachytherapy to treat the local relapse as defined on transperineal mapping biopsy, multipara-metric MRI and Choline PETSCAN on the same treatment planning. Methods: Between October 2013 and June 2016, Twenty-nine patients with local relapse on Choline PET Scan after a primary irradiation had a salvage HDR Brachytherapy (2 fractions of 10 Gy within 4-6 hours in one i
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Gesztesi, László, Zsuzsa S. Kocsis, Kliton Jorgo, Georgina Fröhlich, Csaba Polgár, and Péter Ágoston. "Alterations of Sexual and Erectile Functions after Brachytherapy for Prostate Cancer Based on Patient-Reported Questionnaires." Prostate Cancer 2024 (January 25, 2024): 1–13. http://dx.doi.org/10.1155/2024/5729185.

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The aim of the study was to compare the side effects of high-dose-rate brachytherapy (HDRBT) and low-dose-rate brachytherapy (LDRBT), with a particular focus on the effects on sexual functions and sexual well-being (PROMOBRA study, NCT02258087). Localized low-risk and low-intermediate-risk prostate cancer patients were treated with mono LDR (N = 123, 145 Gy dose) or mono HDR brachytherapy (N = 117, 19/21 Gy). Prior to the treatment and during follow-up (at 3, 6, 9, 12, 18, and 24 months after treatment, and then annually after two years), patients completed patient-reported outcome measurement
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37

De Cicco, Luigi, Andrea Vavassori, Federica Cattani, Barbara A. Jereczek-Fossa, and Roberto Orecchia. "Salvage High Dose Rate Brachytherapy after Primary External Beam Irradiation in Localized Prostate Cancer: A Case Report." Tumori Journal 95, no. 4 (2009): 553–56. http://dx.doi.org/10.1177/030089160909500429.

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No standard treatment exists for locally relapsed prostate cancer after primary external beam radiotherapy with no evidence of distant metastases. Radical prostatectomy, brachytherapy, cryotherapy and high-intensity focused ultrasound are currently used as local salvage treatments. Data on the safety and effectiveness of high dose rate (HDR) brachytherapy in this scenario are limited. We report on a patient who has no evidence of disease and no late urinary or gastrointestinal toxicity 33 months after receiving HDR treatment for recurrent prostate cancer.
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Chicheł, Adam, Wojciech Burchardt, Artur J. Chyrek, et al. "Thermal Boost to Breast Tumor Bed—New Technique Description, Treatment Application and Example Clinical Results." Life 12, no. 4 (2022): 512. http://dx.doi.org/10.3390/life12040512.

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(1) Current breast-conserving therapy for breast cancer consists of a combination of many consecutive treatment modalities. The most crucial goal of postoperative treatment is to eradicate potentially relapse-forming residual cancerous cells within the tumor bed. To achieve this, the HDR brachytherapy boost standardly added to external beam radiotherapy was enhanced with an initial thermal boost. This study presents an original thermal boost technique developed in the clinic. (2) A detailed point-by-point description of thermal boost application is presented. Data on proper patient selection,
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39

Pohanková, Denisa, Igor Sirák, Miroslav Hodek, et al. "Interstitial HDR brachytherapy of penile cancer." Onkologie 19, no. 1 (2025): 11–14. https://doi.org/10.36290/xon.2025.002.

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40

Inoue, K., Y. Watanabe, T. Maeyama, et al. "RSC: Dosimetry in high-dose-rate brachytherapy with a radio-fluorogenic gel dosimeter." Journal of Physics: Conference Series 2167, no. 1 (2022): 012032. http://dx.doi.org/10.1088/1742-6596/2167/1/012032.

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Abstract A nanoclay-based radio-fluorogenic gel (NC-RFG) was used to verify the source position and dose distribution in high-dose-rate (HDR) brachytherapy. The dose response confirmed linearity up to 60 Gy. The source position could be detected with an accuracy of ≤0.3 mm, and the dose distribution near the Ir-192 source showed good agreement with the Monte Carlo simulation. NC-RFG can be expected to be a quality assurance tool suitable for the evaluating the dose distribution in HDR brachytherapy.
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41

Damian, Peter, and Innocent Lugendo. "The Influence of Au, Gd and I Nanoparticles on Radiation Dose Absorption during High Dose Rate Brachytherapy with <sup>192</sup>Ir Source <i></i>." Brazilian Journal of Radiation Sciences 13, no. 2 (2025): e2823. https://doi.org/10.15392/2319-0612.2025.2823.

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The efficacy of high dose rate (HDR) brachytherapy for cervical cancer is often constrained by the high radiation exposure to the healthy tissues that surround the tumor consequently diminishing the therapeutic benefits of the technique. A promising approach to mitigate this challenge is the use of high atomic number (Z) nanoparticles, such as Gold nanoparticles (GNPs), Gadolinium nanoparticles (GdNPs) and Iodine nanoparticles (INPs), which act as radioation dose enhancers. This study evaluates the influence of GNPs, GdNPs and INPs nanoparticles on dose absorption during 192Ir HDR brachytherap
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42

Yamamoto, Toshihiro, Masahito Kido, Hiroshi Sasaki, et al. "High-dose-rate (HDR) brachytherapy with external beam radiotherapy for localized high-risk prostate cancer: Five-year results in 122 patients." Journal of Clinical Oncology 30, no. 5_suppl (2012): 91. http://dx.doi.org/10.1200/jco.2012.30.5_suppl.91.

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91 Background: To present outcome and morbidity of high-dose-rate (HDR) brachytherapy with external beam radiotherapy (EBRT) for localized high risk prostate cancer. Methods: Between May 2005 and April 2009, 122 patients underwent Ir-192 HDR brachytherapy with EBRT and passed after HDR bachytherapy more than one year. The median follow-up was 46 months (range 2-76 months). All patients were high risk and localized prostate cancer. Median PSA was 40.2ng/ml (range 4.1-366ng/ml). Median Gleason Score was 8 (range 6-10). All patients were treated over six months neo-adjuvant hormonal therapy and o
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43

Monge-Cadet, Jeanne, Benjamin Vairel, Mathilde Morisseau, et al. "High-Dose-Rate Brachytherapy for Treatment of Facial Skin Cancers: Local Control, Toxicity, and Quality of Life in 67 Patients." Cancers 16, no. 15 (2024): 2742. http://dx.doi.org/10.3390/cancers16152742.

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While treatment of localized cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) is based on surgery, brachytherapy, which delivers a high dose of radiation to tumor tissue while sparing healthy tissue, is an alternative. Since the withdrawal of iridium wires from the market, brachytherapy has mainly been performed with high-dose-rate iridium-192 (HDR). This study evaluated the efficacy of HDR brachytherapy in terms of local control, survival, toxicity, and quality of life in patients with facial periorificial cutaneous SCC or BCC treated in our center between 2015 and 2021.
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44

Wegener, Eric, Justin Samuels, Mark Sidhom, et al. "Virtual HDR Boost for Prostate Cancer: Rebooting a Classic Treatment Using Modern Tech." Cancers 15, no. 7 (2023): 2018. http://dx.doi.org/10.3390/cancers15072018.

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Prostate cancer (PC) is the most common malignancy in men. Internal radiotherapy (brachytherapy) has been used to treat PC successfully for over a century. In particular, there is level-one evidence of the benefits of using brachytherapy to escalate the dose of radiotherapy compared with standard external beam radiotherapy approaches. However, the use of PC brachytherapy is declining, despite strong evidence for its improved cancer outcomes. A method using external beam radiotherapy known as virtual high-dose-rate brachytherapy boost (vHDRB) aims to noninvasively mimic a brachytherapy boost ra
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Das, KR. "Prostate brachytherapy: HDR or seed implant." Journal of Medical Physics 31, no. 4 (2006): 239. http://dx.doi.org/10.4103/0971-6203.29193.

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46

Lo, T., I. Iftimia, and P. Cronin. "P056 HDR brachytherapy for prostate cancer." European Urology Supplements 13, no. 5 (2014): 129–30. http://dx.doi.org/10.1016/s1569-9056(14)61279-3.

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47

Prévost, B., E. Dansin, C. Verkindre, et al. "HDR endoluminal brachytherapy in lung cancer." Lung Cancer 21 (September 1998): S56. http://dx.doi.org/10.1016/s0169-5002(98)90144-1.

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48

Rübe, Ch, A. Schuck, A. Hillmann, M. Paulussen, H. Jürgens, and N. Willich. "710Intraoperative HDR brachytherapy of Ewing's sarcoma." Radiotherapy and Oncology 40 (January 1996): S181. http://dx.doi.org/10.1016/s0167-8140(96)80719-5.

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49

Scalliet, P., A. Gerbaulet, and B. Dubray. "HDR versus LDR gynecological brachytherapy revisited." Radiotherapy and Oncology 28, no. 2 (1993): 118–26. http://dx.doi.org/10.1016/0167-8140(93)90003-q.

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Jones, Bleddyn, Li Tee Tan, and Robert Kingston. "HDR versus LDR gynaecological brachytherapy revisited." Radiotherapy and Oncology 30, no. 2 (1994): 186. http://dx.doi.org/10.1016/0167-8140(94)90057-4.

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