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Dissertations / Theses on the topic 'He53'

Author: Grafiati

Published: 25 July 2024

Last updated: 31 July 2025

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1

BON, GIULIA. "Dual targeting of HER3 and MEK may overcome HER3-dependent chemoresistance of colon cancers." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2013. http://hdl.handle.net/2108/202145.

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The medical treatment of colorectal cancer (CRC) has evolved greatly in the last years, involving combined chemotherapy protocols and, more recently, new biologic agents. Nevertheless, prognosis remains adverse for patients with metastatic disease and a significant portion of early-stage patients develop recurrence after chemotherapy. Clinical trials are now directed to evaluate new drug combinations and treatment schedules in order to overcome the mechanisms of chemoresistance. By the use of two patient-derived colon cancer cell lines, CC09 (BRAFV600E) and R511 (wt BRAF), and the established

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Aldana, Hidalgo Julio Xavier, Parodi Augusto José Amador, Palacios Jorge Martin Arredondo, et al. "Estrategias de redacción - HE59 201801." Universidad Peruana de Ciencias Aplicadas (UPC), 2018. http://hdl.handle.net/10757/624389.

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Descripción: Estrategias de Redacción es un curso de Humanidades, que brinda al participante un conjunto de herramientas lingüísticas para la redacción en el entorno laboral, tales como el uso apropiado de la normativa del español y la aplicación de estrategias de redacción como la enumerativa y la causal. Estas últimas se emplean en la elaboración de un tipo de documento: el informe de recomendación. Propósito: El curso desarrolla la competencia de comunicación escrita en el primer nivel de logro. La asignatura se orienta a la redacción de textos administrativos que ayuden a optimizar el

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(UPC), Universidad Peruana de Ciencias Aplicadas, and Celis Ingunza Sandy Cecilia. "Creatividad Y Liderazgo-HE50-201601." Universidad Peruana de Ciencias Aplicadas (UPC), 2016. http://hdl.handle.net/10757/639326.

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Creatividad y Liderazgo es un curso de formación general de carácter teórico y práctico que está dirigido a estudiantes de quinto ciclo a más de las Facultades de negocios e Ingeniería y que desarrolla una de las competencias generales de nuestro modelo educativo: Pensamiento Innovador.El curso Creatividad y Liderazgo surge como una respuesta a los vertiginosos cambios tecnológicos y sociales que ocurren en nuestros días los que a su vez producen profundas transformaciones en la cultura corporativa de empresas e instituciones. Esto enfrenta a los ejecutivos a cada vez mayores exigencias profes

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(UPC), Universidad Peruana de Ciencias Aplicadas, and Garcia Soria Juddy Grethel Nora. "Creatividad Y Liderazgo-HE50-201602." Universidad Peruana de Ciencias Aplicadas (UPC), 2016. http://hdl.handle.net/10757/639327.

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Creatividad y Liderazgo es un curso de formación general de carácter teórico y práctico que está dirigido a estudiantes de quinto ciclo a más de las Facultades de negocios e Ingeniería y que desarrolla una de las competencias generales de nuestro modelo educativo: Pensamiento Innovador.El curso Creatividad y Liderazgo surge como una respuesta a los vertiginosos cambios tecnológicos y sociales que ocurren en nuestros días los que a su vez producen profundas transformaciones en la cultura corporativa de empresas e instituciones. Esto enfrenta a los ejecutivos a cada vez mayores exigencias profes

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(UPC), Universidad Peruana de Ciencias Aplicadas, and Ilizarbe Jurado Anndy Antonio. "Creatividad Y Liderazgo-HE50-201701." Universidad Peruana de Ciencias Aplicadas (UPC), 2017. http://hdl.handle.net/10757/639328.

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Creatividad y Liderazgo es un curso de formación general de carácter teórico y práctico que está dirigido a estudiantes de quinto ciclo a más de las Facultades de Negocios e Ingeniería y busca desarrollar una de las competencias generales de nuestro modelo educativo: Pensamiento Innovador.El curso Creatividad y Liderazgo surge como una respuesta a la necesidad de profesionales que cuenten con estrategias y metodologías para afrontar los vertiginosos cambios que ocurren en nuestros días los que a su vez producen profundas transformaciones en la cultura corporativa de empresas e instituciones. E

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6

Bass, Tarek. "Affibody molecules targeting HER3 for cancer therapy." Doctoral thesis, KTH, Proteinteknologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-204593.

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The development of targeted therapy has contributed tremendously to the treatment of patients with cancer. The use of highly specific affinity proteins to target cancer cells has become a standard in treatment strategies for several different cancers. In light of this, many cancer cell markers are investigated for their potential use in diagnostics and therapy. One such marker is the human epidermal growth factor receptor 3, HER3. It has been established as an important contributor to many cancer types. The function of HER3 is to relay cell growth signals from outside of the cell to the inside

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Htun, van der Horst Edward. "The role of ErbB3/HER3 in gliomas and breast cancer." Diss., lmu, 2002. http://nbn-resolving.de/urn:nbn:de:bvb:19-5804.

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8

Claus, J. "The pseudokinase HER3 : structure/function relationships and inhibitor-induced signalling." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1457524/.

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The receptor tyrosine kinase HER3, a pseudokinase in the epidermal growth factor receptor (EGFR) family, is involved in responses to ligands and in the acquired resistance against HER2-directed targeted therapy in breast cancer. In this thesis I aim to further investigate the structure/function relationships at the basis of HER2- HER3 heterodimerisation, particularly in response to inhibitor treatment. The data presented here shows that in HER2+ breast cancer cells treated with the HER2 inhibitor lapatinib, stimulation with the HER3 ligand NRG is able to not only rescue cytotoxicity, but even

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9

Franks, P. W. "A He3 magnetometer for the EDM experiment." Thesis, University of Sussex, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.304321.

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10

Xie, Ting. "Targeting `Undruggable' Cancer Proteins with Irreversible Small Molecule Inhibitors: Her3 and KRas." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11384.

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With the lighting speed revolution of technologies in chemistry and biology, increasing number of proteins which eluded scientists' efforts to block them before and were labeled as `undruggable', were successfully targeted with small molecule inhibitors. During the past five years, I have been working on figuring out the path to inhibit two elusive cancer targets: Her3 and KRas.<br>Chemistry and Chemical Biology

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Miller, Megan Jo. "Novel HER3 and IGF-1R Peptide Mimics and Synthetic Cancer Vaccines." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1408981670.

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12

Park, Deric M., Jinkyu Jung, Jimmy Masjkur, et al. "Hes3 regulates cell number in cultures from glioblastoma multiforme with stem cell characteristics." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-127014.

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Tumors exhibit complex organization and contain a variety of cell populations. The realization that the regenerative properties of a tumor may be largely confined to a cell subpopulation (cancer stem cell) is driving a new era of anti-cancer research. Cancer stem cells from Glioblastoma Multiforme tumors express markers that are also expressed in non-cancerous neural stem cells, including nestin and Sox2. We previously showed that the transcription factor Hes3 is a marker of neural stem cells, and that its expression is inhibited by JAK activity. Here we show that Hes3 is also expressed in cul

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Hashimoto, Kenji. "Investigating a role of HER3 in anti-HER2 target therapy in breast cancer." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:39025871-f32f-4e38-bd14-c13dbc9301f6.

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Background HER2-positive breast cancer is a poor prognostic subgroup, even if treated with anti-HER2 directed therapy. Trastuzumab is an important HER2-targeting antibody but only limited patients respond to this drug, and acquired resistance is a common problem. HER3 has been shown to be a key candidate in mediating resistance to trastuzumab and other ErbB inhibitors. The aims of the project are to investigate the resistance mechanisms and the relevant biomarkers in relation to trastuzumab treatment and resistance in HER2-positive breast cancer, in particular, HER3 subcellular localisation an

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Lazrek, Yassamine. "Ciblage tumoral du récepteur HER3 à l’aide d’anticorps : vers de nouvelles pistes thérapeutiques." Thesis, Montpellier 1, 2013. http://www.theses.fr/2013MON13524.

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De part, leur implication dans la prolifération cellulaire, l'invasion et leur surexpression dans de nombreux cancers, les récepteurs à tyrosine kinase de la famille HER constituent des cibles de choix en oncologie. Parmi ces récepteurs, le récepteur HER3 semble pertinent car il est impliqué dans la tumorigenèse de nombreux cancers (sein, ovaire, pancréas, mélanome…) et il est associé à un mauvais pronostic. De plus, la surexpression du récepteur HER3 est souvent associée à l'apparition de résistance aux thérapies ciblées. Nous avons sélectionné plusieurs anticorps anti-HER3 humains et murins

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Sollome, James Jerome. "Heregulin Activates a Novel HER2/HER3-MTK1-GIT1/ERK1/2 MAPK Signaling Pathway." Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/315554.

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Human MAP3K4 (MTK1) functions upstream of mitogen activated protein kinases (MAPKs). In the studies presented herein, MTK1 is shown to be required for human epidermal growth factor receptor 2/3 (HER2/HER3)-heregulin beta1 (HRG) induced extracellular acidification and cell migration in MCF-7 breast cancer cells. Furthermore, it was shown that HRG stimulation leads to association of MTK1 with tyrosine phosphorylated HER3 in MCF-7 and T-47D breast cancer cells. The MTK1/HER3 association was dependent on HER2 activation and was decreased by pre-treatment with the HER2 inhibitor, lapatinib. Further

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Thomas, Gaëlle. "Ciblage de l'entité HER2/HER3 par des anticorps monoclonaux pour le traitement des cancers du pancréas exprimant faiblement HER2." Thesis, Montpellier 1, 2013. http://www.theses.fr/2013MON1T011.

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Avec un taux de survie à 5 ans inférieur à 5%, l'adénocarcinome pancréatique (PDAC) est l'un des cancers les plus agressifs et pour lequel les thérapies existantes sont largement insuffisantes. Ce cancer est caractérisé par un tissu fibreux dense et un stroma très développé, en constante interaction avec la tumeur, favorisant le développement d'un environnement propice à la progression tumorale. Actuellement, la gemcitabine est la seule chimiothérapie approuvée capable de prolonger légèrement la survie des patients. Une thérapie ciblée dirigée contre l'EGFR, l'erlotinib, a prouvé que le ciblag

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Rüder, Ulrike [Verfasser]. "HER3, CK5/6 und APOBEC3B als Biomarker in histologisch definierten Subtypen des Ovarialkarzinoms / Ulrike Rüder." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2020. http://d-nb.info/1206185929/34.

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18

Teixidó, Febrero Cristina. "Study of the tumor sensitivity of the marine compound elisidepsin and her3 receptor in breast carcinomas." Doctoral thesis, Universitat Autònoma de Barcelona, 2012. http://hdl.handle.net/10803/96888.

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Elisidepsin es un nuevo depsipéptido sintético resultante del programa de investigación interna de PharmaMar para la obtención de productos sintéticos derivados de compuestos naturales de origen marino. Elisidepsin es un fármaco antiproliferativo que presenta actividad contra un amplio conjunto de tipos de tumores, entre ellos él de mama. El presente trabajo de investigación se centra en el estudio y caracterización de mecanismos de sensibilidad y resistencia a elisidepsin y en factores predictivos de respuesta al fármaco en un modelo “in vitro” con diversas líneas celulares tumorales. En é

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Göstring, Lovisa. "Cellular Studies of HER-family Specific Affibody Molecules." Doctoral thesis, Uppsala universitet, Enheten för biomedicinsk strålningsvetenskap, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-156730.

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The human epidermal growth-factor like receptor (HER) family of receptor tyrosine kinases are important targets for cancer therapy. The family consists of four members - EGFR, HER2, HER3 and HER4 - that normally transfer stimulatory signals from extracellular growth factors to the intracellular signalling network. Over-activation of these receptors leads to uncontrolled cell proliferation and is seen in several types of tumours. The aim of the studies reported in this thesis was to study the uptake and effects of affibody molecules against EGFR, HER2 and HER3 in cultured cells. Affibody molecu

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Dahlsson, Leitao Charles. "Rening av bi- och multispecifika cancer-terapeutiska affinitets-proteiner och c-terminalt modifierade anti-HER3 affibodies för avbildningsdiagnostik." Thesis, KTH, Skolan för bioteknologi (BIO), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-190622.

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Affibody molecules are small protein scaffolds that have been engineered to bind to a variety of targets with diversetherapeutic and diagnostic applications. In this study, an array of affibody containing therapeutic constructs,targeting HER2 and HER3, and diagnostic anti-HER3 imaging agents have been purified in preparation for subsequentcancer cell assays and imaging studies in tumour-bearing mice respectively. Herein, the workflow for severalpurification techniques is delineated.

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Schaller, Kerstin [Verfasser], Helga [Akademischer Betreuer] Bernhard, and Christian [Akademischer Betreuer] Peschel. "Generierung zytotoxischer T-Zellen gegen das tumorassoziierte Antigen HER3 / Kerstin Schaller. Gutachter: Helga Bernhard ; Christian Peschel. Betreuer: Helga Bernhard." München : Universitätsbibliothek der TU München, 2012. http://d-nb.info/1031513787/34.

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Nagel, Olaf. "HE5-CD52 und die [alpha]1-3-Fucosyltransferasen [Alpha-1-3-Fucosyltransferasen] des humanen Nebenhodens." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968647464.

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Michaelsen, Vinicius Schenk. "Expressão da proteína erbB-3/HER3 em câncer de pulmão pela técnica de imuno-histoquímica e sua correlação com características clínicopatológicas." Pontifícia Universidade Católica do Rio Grande do Sul, 2008. http://hdl.handle.net/10923/4371.

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Made available in DSpace on 2013-08-07T19:03:59Z (GMT). No. of bitstreams: 1 000403013-Texto+Completo-0.pdf: 1643144 bytes, checksum: 5ccd3fb28b7fe3934f949e3f92a8d4ac (MD5) Previous issue date: 2008<br>Four members belong to the erbB family, erbB1, erbB2, erbB3, and erbB4. Several reports have investigated the expression of members from this family, however with only few regarding to the role of erbB3 on non-small cell lung cancer (NSCLC). The aim of this study was to describe the expression frequency of erbB3 protein in NSCLC and evaluate a possible relationship with clinical parameters suc

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Sielaff, Bernhard. "Molekulare Analyse der Gene und Proteine der Cytochrom P450-haltigen Morpholin-Monooxygenase aus Mycobacterium sp. Stamm HE5." [S.l. : s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=975691856.

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Malm, Magdalena, Nina Kronqvist, Hanna Lindberg, et al. "Inhibiting HER3-Mediated Tumor Cell Growth with Affibody Molecules Engineered to Low Picomolar Affinity by Position-Directed Error-Prone PCR-Like Diversification." Uppsala universitet, Enheten för biomedicinsk strålningsvetenskap, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-202922.

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The HER3 receptor is implicated in the progression of various cancers as well as in resistance to several currently used drugs, and is hence a potential target for development of new therapies. We have previously generated Affibody molecules that inhibit heregulin-induced signaling of the HER3 pathways. The aim of this study was to improve the affinity of the binders to hopefully increase receptor inhibition efficacy and enable a high receptor-mediated uptake in tumors. We explored a novel strategy for affinity maturation of Affibody molecules that is based on alanine scanning followed by desi

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Ricalde, Rodrigues Alexandre. "Production d'He3 liquide polarisé par dilution et étude de la pression osmotique d'un mélange saturé He3-He4 polarisé." Université Joseph Fourier (Grenoble ; 1971-2015), 1995. http://www.theses.fr/1995GRE10240.

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Dans ce mémoire, nous étudions l'effet de la polarisation nucléaire sur l'he#3 liquide. La polarisation change les propriétés physiques de ce système par l'intermédiaire du principe de Pauli. Nous montrons expérimentalement qu'il est possible de produire de l'he#3 liquide avec une polarisation hors équilibre mais stationnaire, dans un réfrigérateur à dilution spécial (de type leiden). Le processus de dilution mis en jeu produit de l'he#3 à la fois froid (13 mk) et polarise (15%, 7 fois la valeur à l'équilibre sous un champ de 7 t). Le comportement du polariseur nous a permis de déterminer la p

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Eckrich, Caroline Elisabeth Verfasser], and Guido [Akademischer Betreuer] [Sauter. "Prävalenz der Tyrosinkinasen-Überexpression in humanen Zelllinien : Eine Gewebe-Mikroarray Analyse von BTK, ZAP70, HER3, HER4, JAK2 / Caroline Elisabeth Eckrich. Betreuer: Guido Sauter." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2011. http://d-nb.info/1020457104/34.

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Peeß, Carmen Maria Verfasser], and Hans-Martin [Akademischer Betreuer] [Jäck. "Entwicklung von Antikörpern gegen den Domäne II beta-Hairpin des HER3-Rezeptors unter Verwendung der Thermus thermophilus SlyD-Scaffoldtechnologie / Carmen Maria Peeß. Gutachter: Hans-Martin Jäck." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2015. http://d-nb.info/1078774587/34.

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Srinivasan, Radhika. "Role of C-erB-4/HER4 and the alternatively spliced extracellular domain isoform of the c-erB-3/HER3 growth factor receptor in normal tissues and in cancer." Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391811.

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Michaelsen, Vinicius Schenk. "Express?o da prote?na erbB-3/HER3 em c?ncer de pulm?o pela t?cnica de imuno-histoqu?mica e sua correla??o com caracter?sticas cl?nicopatol?gicas." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2008. http://tede2.pucrs.br/tede2/handle/tede/1485.

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Made available in DSpace on 2015-04-14T13:34:31Z (GMT). No. of bitstreams: 1 403013.pdf: 1643144 bytes, checksum: 5ccd3fb28b7fe3934f949e3f92a8d4ac (MD5) Previous issue date: 2008-03-28<br>A fam?lia erbB ? composta por quatro membros: erbB1, erbB2, erbB3 e erbB4. Essa fam?lia tem aparecido amplamente em diversos trabalhos, por?m, o estudo particular da prote?na erbB3 no c?ncer de pulm?o ainda permanece muito restrito. O objetivo desse estudo foi descrever a freq??ncia de express?o da prote?na erbB3 em amostras de c?ncer de pulm?o n?o-pequenas (NSCLC) c?lulas, assim como correlacionar os achad

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Honkanen, T. (Tiia). "More efficient use of HER targeting agents in cancer therapy." Doctoral thesis, Oulun yliopisto, 2019. http://urn.fi/urn:isbn:9789526223445.

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Abstract Cancer treatments have remarkably improved over the past years since targeted therapies and immunotherapy have been introduced to the field of oncology. The benefit of these new therapies is often limited, however, by de novo or acquired therapy resistances, which should be noticed when making clinical decisions. In this current work, we studied the prognostic and predictive values of several immunological markers in metastatic HER2-positive breast cancer treated with trastuzumab, because trastuzumab is still given to patients according to the HER2 status only, without certainty of tu

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Tulukcuoglu, Güneri Ezgi. "Development of microfluidic device for high content analysis of circulating tumor cells." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066583/document.

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Le cancer est l'une des principales causes de décès dans le monde. D'après la société américaine contre le cancer; en 2015, un quart des décès aux Etats-Unis est du au cancer du poumon avant même les maladies cardiaques. Cette situation nous incite et bien d'autres scientifiques dans le monde à développer des moyens plus efficaces de traitement, le diagnostic et le dépistage de la maladie. Parce que près de 90% des décès par cancer sont dus à des métastases, de nombreuses études se sont concentrées sur le mécanisme de métastases et sur son impact clinique. Les cellules tumorales circulantes (C

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Ta, Ngoc Ly. "Rôle des signaux pro-survie du récepteur Fas/CD95 dans le cancer colorectal : importance du dialogue moléculaire entre Fas et l’EGFR (Epidermal Growth Factor Receptor)." Thesis, Université Côte d'Azur (ComUE), 2018. http://www.theses.fr/2018AZUR4078.

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Le cancer colorectal (CCR) est la troisième maladie maligne la plus fréquente et la deuxième cause de décès par cancer. La famille des récepteurs tyrosine kinases transmembranaires ErbB a été identifiée comme l'un des principaux moteurs du développement et de la progression du CCR et l'un de ses membres les plus connus, le récepteur du facteur de croissance épidermique (EGFR / ERBB1 / Her1), considéré comme l'une des cibles les plus importantes en traitement CRC. Deux autres membres de la famille ErbB, les récepteurs Her2 et Her3, apparaissent également comme de nouvelles cibles importantes po

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Fridman, Belinda. "Process development for the production of a therapeutic Affibody® Molecule." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-218861.

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Recently HER3, member of the epidermal growth factor receptor family (EGFR), has been found to play a crucial role in the development of resistance towards inhibitors that are given to patients with HER1- and HER2-driven cancers. As HER3 is up-regulated or over-activated in several types of human cancers, it is of outmost importance that new innovative drugs target its oncologic activity. The Affibody® Molecule Z08698 inhibits the heregulin induced signalling of HER3 with high affinity (KD~50 pM). As the Affibody® Molecule is small, has high solubility and outstanding folding kinetics, an effe

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Ta, Ngoc Ly. "Rôle des signaux pro-survie du récepteur Fas/CD95 dans le cancer colorectal : importance du dialogue moléculaire entre Fas et l’EGFR (Epidermal Growth Factor Receptor)." Electronic Thesis or Diss., Université Côte d'Azur (ComUE), 2018. http://theses.univ-cotedazur.fr/2018AZUR4078.

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Le cancer colorectal (CCR) est la troisième maladie maligne la plus fréquente et la deuxième cause de décès par cancer. La famille des récepteurs tyrosine kinases transmembranaires ErbB a été identifiée comme l'un des principaux moteurs du développement et de la progression du CCR et l'un de ses membres les plus connus, le récepteur du facteur de croissance épidermique (EGFR / ERBB1 / Her1), considéré comme l'une des cibles les plus importantes en traitement CRC. Deux autres membres de la famille ErbB, les récepteurs Her2 et Her3, apparaissent également comme de nouvelles cibles importantes po

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Bezler, Martin [Verfasser]. "The HER3 receptor : role as an intervention target in ovarian cancer / Martin Bezler." 2010. http://d-nb.info/1007204923/34.

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Nikolakopoulou, Polyxeni. "The role of endogenous neural stem cells (eNSCs) in metabolic syndrome and aging." Doctoral thesis, 2017. https://tud.qucosa.de/id/qucosa%3A33485.

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Introduction The adult brain exhibits low regenerative ability. Stem cell-based transplantation approaches have been largely unsuccessful, due to the difficulty to recapitulate the complex cytoarchitecture of the central nervous system (CNS). eNSCs are a new therapeutic option as pharmacological activation and increase of their number in vivo is accompanied by powerful neuroprotection in various disease models. Hes3 is expressed in both proliferating and quiescent NSCs, which makes it a useful biomarker for NSC identification. Direct injections of insulin in the adult brain increase the numb

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Chandra, Ankush. "The role of ERBB3 inhibitors as cancers therapeutics." Thesis, 2015. https://hdl.handle.net/2144/16176.

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Cancer is the most fatal disease after cardiovascular disease with over 8.2 million deaths worldwide each year. Ever since the serendipitous discovery of mustard gas as an anti-cancer therapeutic in the 1940s, serious efforts have been put into discovering more chemotherapies. Chemotherapies can be categorized into different groups such as alkylating agents (cisplatin, cyclophosphamide), antimetabolites (5-fluorouracil, Ara-C) and mitotic inhibitors (taxanes, vinca alkoids) among others. While chemotherapies have proven to kill cancer cells by targeting cell division processes, over time, tumo

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Bellos, Angela Ogden. "Illuminating Actionable Biology in Breast Cancer: Novel Predictive and Prognostic Biomarkers." 2017. http://scholarworks.gsu.edu/biology_diss/185.

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Assessing hormone receptors (the estrogen and progesterone receptors) and the human epidermal growth factor receptor 2 (HER2) to guide clinical decision making revolutionized treatment for breast cancer patients. However, in the years since these biomarkers were first incorporated into routine clinical care, only a few others have been validated as clinically useful in guiding adjuvant chemotherapy decisions and are recommended by the American Society of Clinical Oncology (ASCO) for patients with hormone-positive breast cancer. For patients with triple-negative breast cancer (TNBC), which lack

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HUANG, WEN-LIN, and 黃雯琳. "Analysis of a promoter sequence that expressing hepatitis B virus RNA in a human hepatoma cell line, Hep3 B." Thesis, 1990. http://ndltd.ncl.edu.tw/handle/70114291330302077804.

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Nagel, Olaf [Verfasser]. "HE5-CD52 und die α1-3-Fucosyltransferasen [Alpha-1-3-Fucosyltransferasen] des humanen Nebenhodens / vorgelegt von Olaf Nagel". 2003. http://d-nb.info/968647464/34.

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Htun, van der Horst Edward [Verfasser]. "The role of ErbB3-HER3 in gliomas and breast cancer : molecular mechanisms and potential role as therapeutic target / Edward Htun van der Horst." 2002. http://d-nb.info/965889564/34.

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Sielaff, Bernhard [Verfasser]. "Molekulare Analyse der Gene und Proteine der Cytochrom P450-haltigen Morpholin-Monooxygenase aus Mycobacterium sp. Stamm HE5 / von Bernhard Sielaff." 2005. http://d-nb.info/975691856/34.

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Γρίβας, Πέτρος. "Διερεύνηση μοριακών προγνωστικών παραγόντων στον καρκίνο του παχέος εντέρου". Thesis, 2008. http://nemertes.lis.upatras.gr/jspui/handle/10889/2385.

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Ο καρκίνος του παχέος εντέρου αποτελεί ένα από τα συχνότερα κακοήθη νεοπλάσματα παγκοσμίως, προκαλώντας σημαντική νοσηρότητα και θνητότητα. Η συστηματική διερεύνηση της παθογένειας συντελεί σημαντικά στην πρόληψη, έγκαιρη διάγνωση, θεραπεία και πρόγνωση της νόσου. Στην εποχή της μοριακής ιατρικής, η κατανόηση των μοριακών μηχανισμών καρκινογένεσης έχει αναδείξει το ρόλο ενδοκυττάριων σηματοδοτικών μονοπατιών, τα οποία ρυθμίζουν κυτταρικές διαδικασίες, όπως πολλαπλασιασμός, διαφοροποίηση, απόπτωση, αγγειογένεση, διήθηση. Κομβικά συστατικά τέτοιων μοριακών δικτύων αποτελούν οι υποδοχείς αυξητικώ

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