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Dissertations / Theses on the topic 'Head and Neck Malignancy'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Eley, Karen. "Improving the peri-operative management of patients undergoing free tissue transfer for head and neck malignancy." Thesis, University of East Anglia, 2013. https://ueaeprints.uea.ac.uk/47986/.

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The cohort of patients with oral malignancy is typically of advanced age with significant comorbidity. The causative factors for such malignancies, such as tobacco and alcohol, are also those which result in cardiovascular disease. As a result patients undergoing ablative and reconstructive surgery, with free tissue transfer, are at considerable risk of peri-operative morbidity and mortality from both primary and secondary disease. Free flap failure has a significant impact upon patient outcome, with resultant delayed discharge, and increased morbidity and mortality. By optimising co-morbidity

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2

Sundelin, Kaarina. "Head and Neck Cancer : Factors Affecting Tumour Growth." Doctoral thesis, Linköping : Univ, 2007. http://www.bibl.liu.se/liupubl/disp/disp2007/med1032s.pdf.

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3

Hakelius, Malin. "Interactions between Malignant Keratinocytes and Fibroblasts : Studies in Head and Neck Squamous Cell Carcinoma." Doctoral thesis, Uppsala universitet, Plastikkirurgi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-221109.

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Carcinoma growth requires a supportive tumor stroma. The concept of reciprocal interactions between tumor and stromal cells has become widely acknowledged and the connective tissue activation seen in the malignant process has been likened to that of a healing wound. Little is, however, known about the specific characteristics of these interactions, distinguishing them from the interplay occurring between epithelial and stromal cells in wound healing. In order to study differences in the humoral effects of malignant and benign epithelial cells on fibroblasts, we used an in vitro coculture model

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4

Hamdoon, Z. G. "The clinical application of optical coherence tomography for head and neck premalignant/malignant lesions." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1402413/.

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The principle of Optical Coherence Tomography (OCT) is based on the property of light coherence. OCT generates cross-sectional images of two-dimensional objects to obtain in-vitro and in-vivo images of tissues. Non–commercially available OCT systems, which have a higher resolution and scanning rate, have been previously reported. However, some clinical research has already been conducted using the first commercially available OCT device (Niris system) to image the larynx; but applications on oral and skin tissue have not been tested yet. This thesis aims to explore, compare and validate three

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5

Gillgren, Peter. "Body site of cutaneous malignant melanoma : primary tumor location in relation to phenotypic and prognostic factors /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-339-2.

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6

Sun, Aijun. "Radiolabeled acetate PET in oncology imaging studies on head and neck cancer, prostate cancer and normal distribution /." Doctoral thesis, Umeå : Umeå university, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-32980.

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7

Ghazali, N. "Personalising head and neck cancer survivorship : intervention with the Head and Neck Cancer Patients Concerns Inventory in routine head and neck cancer outpatient visits." Thesis, University of Liverpool, 2018. http://livrepository.liverpool.ac.uk/3020175/.

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The Head and Neck Patients Concerns Inventory (HN-PCI) is a self-completed holistic tool that helps patients to disclose items of concern they wish to discuss. The MD study was designed to evaluate the roll-out of HN-PCI in subjects who were unfamiliar with it. The primary aim of the study was to evaluate HN-PCI can help patients self-disclose concerns. The secondary aims were to: (1) categorise HN-PCI items into domains; (2) develop a thematic content analysis; (5) examine associations between concerns and distress; (4) examine associations between clinicopathological factors with HN-PCI cons

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8

Winter, Stuart Charles Alec. "Hypoxia in head and neck cancer." Thesis, University of Bristol, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.428506.

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9

Gluck, Caitlin, and Caitlin Gluck. "HPV Mediated Head and Neck Cancer." Thesis, The University of Arizona, 2016. http://hdl.handle.net/10150/621127.

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The epidemiology of head and neck squamous cell carcinomas (HNSCC), primarily those of the oropharynx, has changed dramatically over the last two decades. Specifically, HNSCC appears to be a distinct entity that is related to infection by human papilloma virus (HPV)(Vokes et al., 2015) (Fakhry et al., 2008). Moreover, the incidence of HPV-associated oropharyngeal (OP) cancers is rising, likely as a consequence of changing life styles and sexual behaviors. These tumors appear to be biologically and clinically distinct from other HNSCC tumors affecting predominantly middle-aged white men having

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10

Pradhan-Palikhe, P. (Pratikshya). "Matrix metalloproteinase-8 as a diagnostic tool for the inflammatory and malignant diseases." Doctoral thesis, Oulun yliopisto, 2011. http://urn.fi/urn:isbn:9789514295096.

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Abstract Matrix metalloproteinases (MMPs) are the zinc-dependent endopeptidases which belong to a large family of proteases. MMPs are responsible for degradation and remodeling of extracellular matrix proteins during growth, organogenesis and tissue turnover. Besides their role in physiological processes, MMPs also influence various pathological processes, i.e., inflammatory diseases and cancers, in which MMPs may ultimately lead to unwanted tissue destruction. One of the most widely studied MMPs is MMP-8. MMP-8 was previously thought to be expressed only by neutrophils. Presently, it is evide

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11

Amr, Bassem Ismail Metwaly Ismail. "Aspects of the preoperative pathway in pancreatic head malignancy." Thesis, University of Plymouth, 2018. http://hdl.handle.net/10026.1/12167.

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Malignancy within the pancreatic head can arise from pancreatic duct, distal bile duct, ampulla or duodenum. Since September 2000, surgery for all pancreatic head malignancy (PHM) has been centralised into regional pancreatic centres where assessment of preoperative imaging and subsequent surgery is undertaken. As part of this guidance, surgery must be performed within 62-days of referral. This project will assess four aspects of the pre-operative pathway in PHM: 1) Potential variation in outcome of patients referred from different sites within a Cancer Network 2) Potential variation in outcom

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12

Coman, W. B. "Optimum management of head and neck cancer /." [St. Lucia, Qld.], 2006. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe19643.pdf.

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13

Veltman, Joris André. "Chromosomal aberrations during head and neck carcinogenesis." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1999. http://arno.unimaas.nl/show.cgi?fid=6943.

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14

Ehsanian, Reza. "Molecular targets in head and neck cancer." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540135.

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15

Chan, Chiu-lung Richie, and 陳肖龍. "Mucosal melanoma of the head and neck." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46632876.

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16

Qureishi, Ali Akhtar Siddique. "Molecular targets in head and neck cancer." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/molecular-targets-in-head-and-neck-cancer(f4b44db3-7db7-4ed6-8b8d-77d3d446b116).html.

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Background: Head and neck cancer (HNSCC) affects 650,000 people annually. Laryngeal cancer (LSCC) and oropharyngeal cancer (OPSCC) are amongst the commonest sub-types. For other cancers e.g. breast cancer, personalised treatments based on tumour markers have improved patient survival. With the exception of human papilloma virus (HPV); there are no clinically utilised biomarkers in HNSCC. Insulin growth factor receptor 1 (IGF-1R) and HPV are promising molecular markers in LSCC and OPSCC respectively. This thesis investigates the use of IGF-1R as a marker of radiotherapy resistance in LSCC and e

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17

Douglas, Catriona Mairi. "Prognostic markers in head and neck cancer." Thesis, University of Manchester, 2011. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:130436.

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Purpose: The management of head and neck squamous cell carcinoma (HNSCC) is complex and often involves multimodality treatment. Currently, most management decisions are based on clinical parameters with little appreciation of patient differences in underlying tumour biology. The identification of biomarkers that predict response to radiotherapy would be clinically useful in determining optimal management. The purpose of the thesis was to investigate potential biomarkers that might predict radiotherapy outcome in patients with HNSCC. Aims: 1) To investigate the hypoxia-associated biomarkers car

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18

Shields, Robert Colquhoun. "Extracellular DNA in head and neck biofilms." Thesis, University of Newcastle upon Tyne, 2014. http://hdl.handle.net/10443/2498.

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Extracellular DNA (eDNA) is a ubiquitous component of the extracellular matrix of microbial biofilms. It has a number of functions that include a role as an adhesin during biofilm attachment, and facilitating matrix stability in mature biofilms. Increasingly, deoxyribonuclease (DNase) enzymes have been shown to reduce the colonisation of many microbial biofilms, both bacterial and fungal. Biofilms are estimated to be responsible for around 60% of bacterial infections, including many chronic diseases. The aim of this work was to determine the role of eDNA in chronic mixed-species biofilm infect

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19

von, Beckerath Mathias. "Photodynamic therapy in the head and neck." Doctoral thesis, Örebro universitet, Institutionen för hälsovetenskap och medicin, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-35953.

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Photodynamic therapy, PDT, is a method to diagnose and treat cancer. In PDT a sensitizer is administered to the patient and this sensitizer is accumulated in tumors. If the sensitizer-containing tumor is subjected to a laser of a specific wavelength the tumor is fluorescing allowing diagnostics. If other wavelengths are used a process involving reactive oxygen species and singlet oxygen is started and the tumor cells are killed. This process thus requires oxygen as well. This thesis investigates how UV-induced damage of the skin and different physiological factors of the skin influences the up

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20

Jonsson, Eva Lindell. "Biomolecular markers in head and neck cancer." Doctoral thesis, Uppsala universitet, Öron-, näs- och halssjukdomar, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-306126.

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Head and neck cancer is a heterogeneous group of tumours, of which certain subgroups such as cancer of the mobile tongue frequently are associated with a relatively poor prognosis due to the high risk of regional failure and mortality rates that haven’t improved in a significant way over the last 3 decades, despite advancements in both diagnostics and treatment. Today we lack means to assess the biological aggressiveness of each individual tumour, which varies largely. Treatment comprises of surgery with additional radiotherapy and medical therapies in more advanced tumours. The focus in this

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21

Nousi, Sofia. "Sensory-motor control of head-neck musculature." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/32103.

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The neural connections between the vestibular, visual, proprioceptive and voluntary inputs are essential for the control of neck posture and movements. One mechanism how this is achieved is by vestibulo-spinal reflexes, such as vestibulo-collic reflex (VCR), and cervico-collic reflexes (CCR). The main role of these reflexes is to stabilize the head either in space or relative to the trunk, respectively. The VCR stabilises the head in space while the CCR tends to re-align the head on the trunk. These two reflexes can work synergistically or an-tagonistically according to context and movement go

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22

Åkervall, Jan. "Prognostic factors in squamous cell carcinoma of the head and neck with emphasis on 11q13 rearrangments and Cyclin D1 overexpression /." Lund : Dept. of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Lund, 1998. http://books.google.com/books?id=xp1rAAAAMAAJ.

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23

Kasaian, Katayoon. "Genomic analysis of head and neck endocrine glands." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/54936.

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Discovering biomarkers and molecular drivers of head and neck endocrine tumors was the inspiration for this thesis. Here, I describe the molecular evaluation of tumors of the thyroid and parathyroid endocrine glands for the purpose of identifying somatic driver alterations in these cancers. While molecular interplay of the germline genomic background of an individual and the somatic genome that emerges throughout the lifetime plays significant roles in increasing the susceptibility to cancer and in driving the malignant phenotype, the major known contributors to cancer remain the acquired soma

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24

Bennett, Kristi Lynn. "Methylation in head and neck squamous cell carcinoma." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1194544327.

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25

Sharpe, D. J. "HOX gene expression in head and neck cancer." Thesis, Queen's University Belfast, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.517517.

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26

Holt, Deborah Jane. "The accuracy of head and neck cancer registration." Thesis, University of Liverpool, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268925.

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27

Andrews, Nigel Anthony. "Intrinsic cellular radiosensitivity in head and neck cancer." Thesis, University of Liverpool, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367189.

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28

Warner, Giles C. "Gene expression profiling of head and neck cancer." Thesis, Queen Mary, University of London, 2004. http://qmro.qmul.ac.uk/xmlui/handle/123456789/1857.

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The purpose of this study was to classify oral squamous cell carcinomas (OSCCs) based on their gene expression profiles, to identify differentially expressed genes in these cancers, and to correlate genetic deregulation with clinical-histopathological data and patient outcome. After conducting proof of principle experiments utilizing six head and neck squamous cell carcinomas (HNSCCs) cell lines, the gene expression profiles of 20 OSCCs and subsequently an additional 8 OSCCs were determined using cDNA microarrays containing 19,200 sequences and the Binary Tree-Structured Vector Quantization (B

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29

El-Attar, Radien. "Prognostic biomarkers for head and neck squamous carcinoma." Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/prognostic-biomarkers-for-head-and-neck-squamous-carcinoma(436032f3-acba-49d5-889e-8ad5f6852dd9).html.

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Head and neck cancer is the 6th most common cancer and is generally treated with surgery and post surgical radiotherapy (RT) alone or in combination with chemotherapy (CT). Over 50% of the patients fail to respond to such treatment while suffering the undesirable side effects of radio-chemotherapy. This highlights the need for new strategies to be able to select patients who could benefit from a specific treatment type to spare cost and suffering to the patients. Furthermore, there is need for targeted and effective therapeutics for this disease. TRAIL and Smac mimetics are novel promising ant

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30

Murray, Patrick Francis. "Immunomodulation within the head and neck tumour microenvironment." Thesis, University of Hull, 2014. http://hydra.hull.ac.uk/resources/hull:10124.

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Changes in the immune response have been implicated in the progression of squamous cell carcinoma of the head and neck (HNSCC). Evidence is emerging that processes within the tumour microenvironment can lead to immune modulation and subsequent tumour growth or metastasis. The hypothesis of this thesis is that the HNSCC tumour microenvironment will have increased levels of cytokines that produce an overall negative effect on the cellular cytotoxic immune response against the malignant cells. Specifically, it is hypothesised that a Th-2-like anti-inflammatory response will favour tumour cell pro

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31

Benaich, Nathan. "MicroRNA modulators of head and neck cancer metastasis." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648432.

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32

Landström, Fredrik. "Curative electrochemotherapy in the head and neck area." Doctoral thesis, Örebro universitet, Institutionen för hälsovetenskap och medicin, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-42215.

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33

Sailan, Ahmad Tarmidi. "HPV and p16 in head and neck cancer." Thesis, University of Dundee, 2010. https://discovery.dundee.ac.uk/en/studentTheses/b5f54490-758e-4aaa-9cc4-3de043c4c9ce.

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There is some evidence to suggest that human papilloma virus (HPV) may play a causal role in head and neck carcinoma (HNSCC). The aim of this study was to investigate the prevalence of HPV DNA in HNSCC and to determine whether any correlation exists with p16 or survival. An initial pilot study of sixty formalin-fixed HNSCC was carried out in order to optimise the methodology for the PCR and immunohistochemistry. A further 84 benign lesions, 12 dysplasias and additional 80 HNSCC were also included. In the pilot study the prevalence of all HPV types was 67% of which 18% were high risk-HPV (HR-HP

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34

Sun, Yan. "Genetic Alterations in Advanced Head and Neck Cancer." Freiburg i. Br. : Universität, 2000. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB8619077.

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35

Beasley, William. "Optimising adaptive radiotherapy for head and neck cancer." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/optimising-adaptive-radiotherapy-for-head-and-neck-cancer(96e831b0-751a-454d-8a6d-4dd490b6a88f).html.

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Anatomic changes occur throughout head and neck radiotherapy, and a new treatment plan is often required to mitigate the resulting changes in delivered dose to key structures. This process is known as adaptive radiotherapy (ART), and can be labour-intensive. The aim of this thesis is to optimise ART, addressing some of the technical and clinical challenges facing its routine clinical implementation. Optimising the frequency and timing of adaptive replanning is important, and it has been shown here that intensity modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) are equa

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36

Kulasinghe, Arutha Jeevana. "Circulating tumour cells in head and neck cancers." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/110534/1/Arutha%20Jeevana_Kulasinghe_Thesis.pdf.

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Metastasis in head and neck cancer patients is responsible for over 50% of deaths. There are currently no tools to identify patients at risk of developing metastasis. Circulating tumour cells (CTC) represent a transient cancer cell population in the blood. In this study, the researcher has developed CTC isolation methodologies and used novel culture formulations to expand patient derived CTCs for therapy testing. Furthermore, the researcher identified biomarkers present on CTCs which could select patients for immunotherapies, a current unmet need. This work sets the foundation for a personaliz

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37

Thamm, Carla. "A discursive construction of head and neck cancer." Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/208180/1/Carla_Thamm_Thesis.pdf.

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This research investigated how discourse influences patients’ and healthcare professionals’ response to head and neck cancer. Using a critical constructionist lens, the study explored how common discourse is created and maintained through power relationships between health professionals, people living with the illness and the disease itself. Findings indicate that the social construction of head and neck cancer is shaped by a discourse of deviance, managed by historical institutional power structures, and presented as a journey of survival. An open dialogue is recommended to promote reflection

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38

Grip, Helena. "Biomechanical assessment of head and neck movements in neck pain using 3D movement analysis." Doctoral thesis, Umeå : Umeå University, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1600.

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39

Gu, Xiaolian. "p63 and epithelial homeostasis studies of p63 under normal, hyper-proliferative and malignant conditions /." Doctoral thesis, Umeå : Umeå university, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-33894.

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40

Teng, Chia-Chi. "Head and neck lymph node region delineation with automatic segmentation and image registration /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/6119.

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41

Estep, Christina Renee. "Modeling of the human head/neck system using rigid body dynamics." Thesis, This resource online, 1992. http://scholar.lib.vt.edu/theses/available/etd-10062009-020148/.

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42

Van, Heerden Willem F. P. "Pathology of the head and neck : a retrospective appraisal /." Access to E-Thesis, 2003. http://upetd.up.ac.za/thesis/available/etd-10052005-153741/.

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Thesis (D.Sc.(Odontology))--University of Pretoria, 2003.<br>"Published work submitted to the University of Pretoria for the degree of Doctor of Science in Odontology (Oral pathology)". Includes bibliographical references. Also available online.

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43

Nordemar, Sushma. "Methods for early diagnosis of head and neck cancer /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-872-6/.

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44

Paulides, Margarethus Marius. "Development of a clinical head and neck hyperthermia applicator." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2007. http://hdl.handle.net/1765/10599.

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45

文偉倫 and Wai-lun Matthew Man. "p15 and p16 genes in head and neck carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B31224945.

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46

Hunter, Keith David. "Gene expression analysis of head and neck cancer development." Thesis, University of Glasgow, 2005. http://theses.gla.ac.uk/1712/.

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Microarray analysis was performed on 32 head and neck keratinocytes cultures using Affymetrix U133A/B genechips. The panel of cultures included normal cells, mortal and immortal cultures of dysplastic keratinocytes and mortal and immortal cultures from carcinomas, all grown to a standard protocol. The overall GEP revealed that many of the well-established HNSCC molecular markers associated with motility and invasion were up-regulated in the mortal cells, particularly in the mortal carcinomas. Immortal NHSCC cells showed elevated expression of cell-cycle markers and loss of differentiation mark

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47

Raji, Halimat-Shaddiya Yewande. "Investigation of head-neck tapers in modular hip prostheses." Thesis, Queen Mary, University of London, 2018. http://qmro.qmul.ac.uk/xmlui/handle/123456789/33929.

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Corrosion at the head-neck junction of total hip replacements is a poorly understood phenomenon with an incidence of 1 - 2 %. Concerns around taper junction corrosion have focused on design factors including changes in taper surface topography and geometry as well as operating conditions such as high bearing surface friction and fluid ingress-egress at the taper junction. Hence, this thesis considered 3 aspects of the head taper junction namely: (1) frictional torque at the bearing surface and below the taper junction for varying head sizes and bearing material combinations, (2) Cobalt and Chr

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48

Modasia, Bhavika. "PTTG, PBF and p53 in head and neck cancer." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7574/.

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Head and neck squamous cell carcinoma (HNSCC) is the 6th most common cancer worldwide and poses a significant health burden due to its rising incidence. The proto-oncogene PTTG is overexpressed in HNSCC and correlates with poor patient prognosis. A recent unpublished GEO profile eDNA array analysis has further suggested a potential upregulation of its binding partner PBF in HNSCC. PTTG and PBF cause transformation in vitro and tumour formation in vivo, both effects thought to be partly mediated by their interactions with the tumour suppressor protein p53. Dysregulation of the p53 pathway is fr

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49

Arbisser, Amelia M. "Multi-atlas segmentation in head and neck CT scans." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/76905.

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Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2012.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 45-46).<br>We investigate automating the task of segmenting structures in head and neck CT scans, to minimize time spent on manual contouring of structures of interest. We focus on the brainstem and left and right parotids. To generate contours for an unlabeled image, we employ an atlas of labeled training images. We register each of these images to the unlabeled target image, transform their str

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50

Meregaglia, M. "Valuing follow-up programs in head and neck cancer." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2018. http://researchonline.lshtm.ac.uk/4649756/.

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This thesis deals with the topic of head and neck cancer (HNC) follow-up from a health economics perspective. Despite recent advances in treating primary HNC, the long-term prognosis of these patients is still poor due to a high risk of cancer recurrence. Until now, there is no agreement about the best way of monitoring patients after the end of therapies. Moreover, patients’ preferences for alternative surveillance schemes are unknown. A multicentre randomized controlled trial comparing two follow-up strategies of different intensity is currently ongoing in Italy. This thesis aims at filling

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