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Journal articles on the topic 'Head and neck tumour'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

Silva, Andreia, Patrícia Caixeirinho, Miguel Vilares, et al. "Retrospective Study of 114 Free Flaps for Head and Neck Oncological Reconstruction in a Portuguese Tertiary Cancer Center." Acta Médica Portuguesa 35, no. 3 (2022): 192. http://dx.doi.org/10.20344/amp.13734.

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Introduction: The Portuguese experience in microsurgical reconstruction of the head and neck after oncological surgery is scantly described. The primary aim of this study was to characterize the use of microvascular reconstruction after head and neck tumor resection in a Portuguese tertiary oncological centerMaterial and Methods: The authors retrospectively evaluated 114 microvascular free flap procedures performed for head and neck reconstruction after oncological resection in a department of Head and Neck Surgery of a Portuguese tertiary oncological center. Patients were operated on from Jan

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2

Baharudin, A., A. Khairuddin, A. Nizam, and A. R. Samsuddin. "Evaluation of irradiated salivary gland function in patients with head and neck tumours treated with radiotherapy." Journal of Laryngology & Otology 123, no. 1 (2008): 108–13. http://dx.doi.org/10.1017/s0022215108002466.

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AbstractIntroduction:Radiotherapy is an important treatment modality for head and neck tumours. One of its major drawbacks is post-treatment salivary gland hypofunction. This study was performed to objectively evaluate the salivary gland function in post-irradiated head and neck tumour patients.Methods:We performed a cross-sectional study of 30 patients with head and neck tumours who had received radiotherapy. Unstimulated and stimulated whole salivary flow rates were assessed in these 30 patients, and compared with those of 30 normal subjects. Unstimulated whole saliva was measured by the dra

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3

Ślaska, Brygida, Magdalena Surdyka, Adam Brodzki, et al. "Mitochondrial D-loop mutations can be detected in sporadic malignant tumours in dogs." Bulletin of the Veterinary Institute in Pulawy 58, no. 4 (2014): 631–37. http://dx.doi.org/10.2478/bvip-2014-0096.

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Abstract The aim of this study was to identify mutations in the D-loop region of mtDNA in head, neck, and limb tumours in dogs, and determination of their relationship with the process of neoplastic transformation. Blood and tumour tissue samples from 19 dogs with diagnosed sporadic malignant tumours were analysed. DNA extraction, amplification, and sequencing of the mtDNA D-loop, and bioinformatic analyses were performed. Five mutations and 19 polymorphisms were observed in 68.42% of all tumours. Polymorphic variants were noted in 42.86% of the head and neck tumours and in 58.33% of the limb

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4

GAZE, M. N., and JANET A. WILSON. "REVIEW Head and neck tumour immunology." Clinical Otolaryngology 13, no. 6 (1988): 495–99. http://dx.doi.org/10.1111/j.1365-2273.1988.tb00324.x.

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5

Jude, Ogechukwu Okoye, Sylvester Ibekailo Nnaemeka, Ajuluchukwu Ngokere Anthony, and Okechi Obioma. "Warthin Tumour-Associated Synchronous Neoplasia and COVID-19: Does SARS-CoV-2 Infection Increase the Risk of Benign Tumours and Cancer?" Journal of Medical Laboratory Science 30, no. 4 (2020): 11–25. https://doi.org/10.5281/zenodo.4364910.

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<strong>ABSTRACT</strong> <strong>Purpose:</strong> This review determined the prevalence of Warthin tumour (WT)-associated synchronous neoplasia or tumours (STs) in a bid to identify high-risk anatomical sites of tumourigenesis. It also highlights hypothetical pathways of SARS-CoV-2-associated tumourigenesis. <strong>Hypothesis: </strong>It is hypothesized that SARS-COV-2-host angiotensin-converting enzyme 2 (ACE2) complex induces cytokine release syndrome and thrombocytopenia with concomitant stimulation of sialadenitis, fibrosis, hyperplasia, metaplasia and premalignant tumours. <strong>Met

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6

Barnes, Precious, and Roland Osei Saahene. "Abstract B028: Expression of NOTCH1 in head and neck tumours at selected hospitals in Ghana." Molecular Cancer Therapeutics 23, no. 6_Supplement (2024): B028. http://dx.doi.org/10.1158/1538-8514.synthleth24-b028.

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Abstract Head and neck tumors (HNT) are of paranasal sinuses origin (the salivary glands and the upper aerodigestive tract). It constitutes the sixth most common tumors. Studies have shown that, factors such as tobacco and alcohol intake and viral infections may increase the relative risk to the tumor. Notch1 pathways are frequently altered in many tumors, however, the clinical significance of NOTCH1dysregulation in head and neck tumors is poorly understood. METHOD: The aim of this study was to investigate the expression NOTCH1 in head and neck tumor and also to elucidate the various anatomica

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Aremu, Shuaib K., Kayode Rasaq Adewoye, and Tayo Ibrahim. "Immunotherapy for head and neck cancers." International Surgery Journal 6, no. 10 (2019): 3884. http://dx.doi.org/10.18203/2349-2902.isj20194465.

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Head and neck squamous cell carcinoma (HNSCC) is a frequent tumour which arises from various anatomical areas in the head and neck region. HNSCC has multiple resistance mechanisms through which it evades the immune responses. It is particularly characterized by an immunosuppressive environment which includes the release of immunosuppressive factors, expansion, and expansion of immune cells which have inhibitory activity reduction of tumour immunogenicity. Human papillomavirus positive (HPV+) HNSCC tumours have one of the higher levels of T cells infiltration. Studies which explore this relatio

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8

Pfleiderer, A. G., P. Thomson, and C. M. Milroy. "ENT presentation of Ollier's disease." Journal of Laryngology & Otology 105, no. 2 (1991): 148–50. http://dx.doi.org/10.1017/s002221510011521x.

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AbstractCartilaginous tumours occurring in the head and neck are usually regarded and seen as solitary lesions. However, we present an unique case where the cartilaginous tumour in the ENT region was the presenting feature of Ollier's disease (multiple enchondromatosis). It is recommended that further investigations be carried out in patients with cartilaginous tumours presenting in the head and neck to exclude the possible presence of this unusual and interesting syndrome.

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9

Di Martino, Ercole, Bernd Sellhaus, Ralf Hausmann, Ralf Minkenberg, Melanie Lohmann, and Martin W. Esthofen. "Survival in second primary malignancies of patients with head and neck cancer." Journal of Laryngology & Otology 116, no. 10 (2002): 831–38. http://dx.doi.org/10.1258/00222150260293664.

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Second primary tumours occur frequently in patients with a history of head and neck malignancies. Delays in making an early and correct diagnosis can seriously affect the therapy management and survival.This was a retrospective study of 120 patients with a history of head and neck cancer, presenting with a second primary tumour. Current follow-up strategies and the use of routine sonographic imaging of the head and neck regions were evaluated, and the impact that tumour chronology, the tumour site and the various treatment modalities have on the survival were assessed. Forty-two per cent of pa

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10

Umid Sunnatovich, Mamedov, and Sultonova Lola Jakhonqulovna. "Comparative Study Of The Results Of Treatment With A Modern Modified Method Of Separating Lymph Nodes For Throat Cancer." Journal of Neonatal Surgery 14, no. 12S (2025): 12–16. https://doi.org/10.52783/jns.v14.3090.

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The results of studies conducted to date worldwide show that one of the most important prognostic signs of head and neck squamous cell carcinoma is the presence of metastases. Tumours of the oropharynx are complex anatomically and histologically because of the specificity for the detection of metastases in the thorax, computed tomography or magnetic resonance imaging of the chest is performed. In malignant tumours of head and neck organs spread locally, then metastasise to adjacent lymph nodes in the neck. Spread to local lymph nodes is partly related to tumour size, grade and aggressiveness.

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11

Gandhi, Yash A., Narendra Hirani, Rashmi D. Sorathiya, Ajeet Kumar Khilnani, Dhruvin Shah, and Mridima Chandra. "Post traumatic schwannoma over right temporo-zygomatic region: a case report." International Journal of Otorhinolaryngology and Head and Neck Surgery 10, no. 6 (2024): 773–75. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20243527.

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Schwannomas are benign tumour. Post traumatic schwannoma over head and neck region is a rare entity. The occurrence of head and neck schwannomas is approximately 25-50%. The most common site of occurrence of schwannoma in head and neck region is found to be lateral part of neck. Schwannoma is a radio-resistant tumour. Complete surgical excision is the definitive management. The characteristic histopathological finding in Schwannoma is Antoni A area and Antoni B area of cellularity and Verocay bodies. We report a rare case of post traumatic schwannoma over right temporo-zygomatic region in an 1

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van der Laan, B. F. A. M., G. BARIS, R. Th Gregor, F. J. M. Hilgers, and A. J. M. Balm. "Radiation-induced tumours of the head and neck." Journal of Laryngology & Otology 109, no. 4 (1995): 346–49. http://dx.doi.org/10.1017/s0022215100130117.

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AbstractIn order to study the induction of malignancy in normal tissues due to ionizing radiation, we reviewed the files of 2500 patients with a tumour of the head and neck treated at the Netherlands Cancer Institute (Antoni van Leeuwenhoek Ziekenhuis), Amsterdam, from 1977 to 1993. We then checked whether or not these patients had been previously irradiated. Patients with a thyroid carcinoma or skin cancer were excluded from the study, since it is generally known that previous irradiation is a risk factor in these tumours. Eighteen patients were found to have a malignancy within a previously

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13

Eldabe, S. S., and D. M. Ryall. "Anaesthesia for head and neck tumour surgery." Current Anaesthesia & Critical Care 7, no. 1 (1996): 9–14. http://dx.doi.org/10.1016/s0953-7112(96)80025-1.

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Sim, Sing Yang, and Ma’en Al-Mrayat. "Thyroid Paraganglioma- An Unusual Head and Neck Tumour." Journal of the Endocrine Society 5, Supplement_1 (2021): A962. http://dx.doi.org/10.1210/jendso/bvab048.1966.

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Abstract Paragangliomas are neuroendocrine tumour originating from the neural crest-derived paraganglia with majority arising from the head and neck. (1)Thyroid paraganglioma are exceedingly rare neuroendocrine tumours accounting for &lt;0.1% of thyroid malignancy (1) We present a 57 years old gentleman who was referred to ENT surgeon following discovery of a two month history of lump on his left neckIt has not changed in size and not caused any symptoms such as anxiety, sweats, palpitations, dizziness or unexplained headaches. He has a Past medical history of epilepsy following a Road tra

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15

Flavell-Birch, Alice, Helen D. Brasch, and Swee T. Tan. "Parotid mucoepidermoid carcinoma with extensive intravenous metastasis: a case report." Australasian Journal of Plastic Surgery 4, no. 1 (2021): 71–74. http://dx.doi.org/10.34239/ajops.v4n1.244.

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Salivary tumours are uncommon, comprising only 2–5 per cent of head and neck neoplasms,1 with mucoepidermoid carcinoma (MEC) being the most common salivary cancer in both adults and children.1–4 Clinically, head and neck MEC can present variably from being asymptomatic to locally or metastatically aggressive.5,6 Treatment is primary surgical resection with neck dissection. The use of adjuvant radiotherapy is indicated for patients at high risk of recurrence, such as those with a high tumour stage, positive resection margins and high histological grading.6–8

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16

Gustafsson, H., A. Kale, A. Dasu, A. Lund, P. H. Edqvist, and K. Roberg. "EPR Oximetry of Cetuximab-Treated Head-and-Neck Tumours in a Mouse Model." Cell Biochemistry and Biophysics 75, no. 3-4 (2017): 299–309. http://dx.doi.org/10.1007/s12013-017-0814-5.

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Abstract Head and neck squamous cell carcinoma (HNSCC) tumours are associated with high mortality despite advances in therapy. The monoclonal antibody cetuximab (Erbitux®) has been approved for the treatment of advanced HNSCC. However, only a subset of HNSC patients receiving cetuximab actually responds to treatment, underlining the need for a means to tailor treatments of individual patients. The aim of the present study was to investigate the effect of cetuximab treatment on tumour growth, on tumour partial oxygen pressure as measured by LiPc electron paramagnetic resonance oximetry and on t

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He, S., P. Li, S. He, et al. "Detection of circulating tumour cells with the CellSearch system in patients with advanced-stage head and neck cancer: preliminary results." Journal of Laryngology & Otology 127, no. 8 (2013): 788–93. http://dx.doi.org/10.1017/s0022215113001412.

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AbstractObjective:To assess the feasibility and clinical value of using the CellSearch system to detect circulating tumour cells in patients with advanced-stage head and neck squamous cell carcinoma.Methods:Circulating tumour cells were isolated and counted via positive selection utilising magnetically labelled anti-epithelial cell adhesion molecule and immunocytochemical staining for cytokeratin. The correlation between circulating tumour cell presence and clinical features was evaluated in nine patients newly diagnosed with advanced-stage (stage III or IV) head and neck squamous cell carcino

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18

Troost, E. G. C., J. Bussink, C. M. L. van Herpen, W. J. G. Oyen, J. H. A. M. Kaanders, and B. A. W. Hoeben. "18F-FLT PET changes during radio - therapy combined with cetuximab in head and neck squamous cell carcinoma patients." Nuklearmedizin 53, no. 02 (2014): 60–66. http://dx.doi.org/10.3413/nukmed-0625-13-09.

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SummaryAim: Early treatment response of head and neck cancer to radiotherapy concomitant with cetuximab was monitored by repetitive PET imaging with the proliferation tracer 18F-FLT. Patients, methods: Five head and neck cancer patients, treated with radiotherapy and concomitant cetuximab following cetuximab induction, received four 18F-FLT PET-CT scans before and during treatment. Changes in SUVpeak, SUVmean and CT- and PET-segmented gross tumour volumes were evaluated, as were correlations with immu- nohistochemical staining for Epidermal Growth Factor Receptor (EGFR) and Ki-67 (proliferatio

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Azman, Aeisyah Binti, Ranveer Singh Gill, Shashi Gopalan Marimuthu, Radha Kodiappan, and Sukanya Banerjee Nair. "Unveiling the unseen: anterior nasal septal schwannoma." International Journal of Otorhinolaryngology and Head and Neck Surgery 11, no. 1 (2025): 75–78. https://doi.org/10.18203/issn.2454-5929.ijohns20250122.

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Schwannomas also known as neurilemmomas are slow-growing, encapsulated benign peripheral nerve sheath tumours that arise from Schwann cells. It has no gender or racial predilection and commonly occur between the 3rd to 6th decades. Approximately 45% of schwannomas arise from the head and neck region. Sinonasal and paranasal schwannomas however are relatively rare tumours and not commonly documented, accounting less than 4% of all head and neck schwannomas. Schwannomas arising from the nasal septum are rarely encountered, with only few cases reported. Here we report a case of a 50-year-old lady

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Savage, C. R., and L. A. Zimmer. "Oncogenic osteomalacia from pterygopalatine fossa mass." Journal of Laryngology & Otology 123, no. 9 (2009): 1052–54. http://dx.doi.org/10.1017/s0022215109004927.

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AbstractIntroduction:Oncogenic osteomalacia, or tumour-induced osteomalacia, is an uncommon cause of osteomalacia. It has been reported to occur in patients with hypophosphataemia due to excess renal phosphate excretion secondary to mesenchymal tumours. Occurrence of this pathological process in the head and neck is extremely rare.Methods:Case report and literature review.Results:We present a case of a 73-year-old woman with tumour-induced osteomalacia. She was initially followed by the endocrinologists for osteomalacia and pathological fractures. An indium-111 pentetreotide scan showed activi

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Gonzalez-Compta, X., M. Mañós-Pujol, M. Foglia-Fernandez, et al. "Oncogenic osteomalacia: case report and review of head and neck associated tumours." Journal of Laryngology & Otology 112, no. 4 (1998): 389–92. http://dx.doi.org/10.1017/s0022215100140551.

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AbstractOncogenic osteomalacia is an uncommon syndrome characterized by mineral metabolism abnormalities that disappear after the resection of an associated tumour. Head and neck is the second most frequent location of these tumours. We describe a case with an ethmoido-frontal phosphaturic mesenchymal tumour and review oncogenic osteomalacia-associated tumours. Among 21 cases found, 57 per cent affected the sinonasal area and 20 per cent the mandible. The diagnosis of the tumour lasted a mean of 4.7 years from the onset of osteomalacia, and most of them showed a significant vascular component.

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SANTHOSHA KULAL, BHASKAR VISHWANATHAN, and GEETA SN. "A prospective study to assess for the prognostic value of tumour volume reduction rate in head and neck cancer, during definitive chemo-radiation in a tertiary care hospital." GSC Advanced Research and Reviews 15, no. 3 (2023): 273–86. http://dx.doi.org/10.30574/gscarr.2023.15.3.0286.

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Tumour volume (TV) is an important factor influencing Radiation therapy(RT) outcome of patients. Logically, total dose and its fractionation should be tailored to the initial number of tumor cells which strongly correlated with tumor volume (TV) rather than to the tumor diameter or stage T. Aims and objectives: To assess tumour volume reduction rate weekly in patients with biopsy proven head and neck cancers treated with definitive chemo-radiation ant to correlate with histology haemoglobin and BMI . Methods and Materials: All oral cavity, oropharyngeal, hypopharyngeal, nasopharyngeal, and lar

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Watkinson, J. C., C. E. C. Todd, C. R. Lazarus, M. N. Maisey, and S. E. M. Clarke. "Technetium–99m(v) Dimercaptosuccinic acid planar scintigraphy in head and neck cancer: Clinical, scintigraphic and radiological study." Journal of Laryngology & Otology 104, no. 10 (1990): 783–89. http://dx.doi.org/10.1017/s0022215100113908.

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AbstractTechnetium-99m (Tc99m)(v) Dimercaptosuccinic Acid (DMSA) is animaging agent which has been proposed as a scintigraphic marker for head and neck squamous cell carcinoma. Fifty-four patients were studied of whom 51 had a head and neck tumour. All patients were examined and then imaged using Tc99m(v) DMSA scintigraphy and computerized tomography.Scintigraphy was less sensitive than clinical examination in the detection of patients with cancer, patients with primary tumours and patients with metastatic neck disease. CT was as sensitive and as accurate as clinical examination but more senst

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Lewis-Jones, H., S. Colley, and D. Gibson. "Imaging in head and neck cancer: United Kingdom National Multidisciplinary Guidelines." Journal of Laryngology & Otology 130, S2 (2016): S28—S31. http://dx.doi.org/10.1017/s0022215116000396.

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AbstractThis guideline is endorsed by the specialty associations involved in the care of head and neck cancer patients in the UK. This paper summarises the current imaging modalities in use for head and neck cancer evaluation. It highlights their role in the management with recommendations on modality choice for each cancer subsite.Recommendations• Offer appropriate radiological imaging, based on tumour extent, site and local expertise, to stage tumours and plan treatment for patients diagnosed with head and neck cancer. (G)• Consider positron emission tomography combined with computed tomogra

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Capatina, Cristina, Georgia Ntali, Niki Karavitaki, and Ashley B. Grossman. "The management of head-and-neck paragangliomas." Endocrine-Related Cancer 20, no. 5 (2013): R291—R305. http://dx.doi.org/10.1530/erc-13-0223.

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Paragangliomas (PGLs) are tumours originating from neural crest-derived cells situated in the region of the autonomic nervous system ganglia. Head-and-neck PGLs (HNPGLs) originate from the sympathetic and parasympathetic paraganglia, most frequently from the carotid bodies and jugular, tympanic and vagal paraganglia, and are usually non-catecholamine secreting. Familial PGLs are considered to be rare, but recently genetic syndromes including multiple PGLs and/or phaeochromocytomas have been more thoroughly characterised. Nowadays, genetic screening for the genes frequently implicated in both f

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Linecker, A., C. Kermer, I. Sulzbacher, et al. "Uptake of 18F-FLT and 18F-FDG in primary head and neck cancer correlates with survival." Nuklearmedizin 47, no. 02 (2008): 80–85. http://dx.doi.org/10.3413/nukmed-0128.

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SummaryThe aim of the study was to determine the practicability of 18F-FLT in tumours of the head and neck area in terms of visualization, a possible correlation between FLT uptake and proliferation fraction as determined by Ki-67 immunostaining, and if tumoural FLT-uptake has a prognostic meaning, as determined by a correlation to patient survival time. Results were compared to 18F-FDG. Patients, methods: 20 patients with previously untreated lesions of the head and neck area, which were clinically highly suspicious to be malignant, underwent PET scans with 18F-FLT and 18F-FDG, a CT of the he

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Talmi, Yoav P., Gregory T. Wolf, Mark Hazuka, and Charles J. Krause. "Unknown primary of the head and neck." Journal of Laryngology & Otology 110, no. 4 (1996): 353–56. http://dx.doi.org/10.1017/s0022215100133602.

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AbstractThe occurrence of metastases to the cervical lymph nodes from an unknown primary tumour is seen in approximately three to six per cent of patients with cervical adenopathy and the primary tumour commonly remains elusive. Single modality treatment is occasionally advocated but combined treatment seems to obtain the best results.A retrospective analysis of patients' charts with unknown primary of the head and neck in theUniversity of Michigan Medical Center was undertaken for the years 1978–1992. Forty-eight records met study criteria and were reviewed.Our series' size and heterogeneity

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Poonam, S. Khairnar, Kar Rajesh, Sahoo Mamata, et al. "Role of Elective Neck Dissection in Clinically Negative Neck Nodes in Head and Neck Malignancies." International Journal of Pharmaceutical and Clinical Research 14, no. 9 (2022): 280–89. https://doi.org/10.5281/zenodo.13324173.

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<strong>Background: </strong>In this study, we wanted to evaluate accuracy of clinical intra operative lymph node assessment in patients with head and neck cancer, define the degree of correlation between clinical preoperative assessment and histopathological examination in patients with head and neck cancer, determine as to whether the use of a selective neck dissection used electively on all patients presenting with head and neck cancer and clinically N0 necks improve survival, disease-free survival and loco-regional disease control rates. <strong>Materials and Methods: </stro

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Laccourreye, Ollivier, Eric Chabardes, Agnés Mérite-Drancy, et al. "Implantation metastasis following percutaneous endoscopic gastrostomy." Journal of Laryngology & Otology 107, no. 10 (1993): 946–49. http://dx.doi.org/10.1017/s0022215100124879.

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AbstractSince it was first described, the original percutaneous endoscopic gastrostomy (PEG) technique has proved to be a valuable adjunct in patients with head and neck tumours. This procedure is being increasingly utilized in the face of swallowing impairment related to head and neck carcinoma. Although generally well tolerated, it may be associated with complications. In this report, we document tumour implantation at the percutaneous endoscopic gastric site and review the report cases. It appears that implantation metastasis does alter prognosis.

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Abhay. D. Havle, Et al. "Precision Medicine in Head and Neck Cancer: Tailoring Therapies to Molecular Profiles." International Journal on Recent and Innovation Trends in Computing and Communication 11, no. 7 (2023): 432–38. http://dx.doi.org/10.17762/ijritcc.v11i7.9430.

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Head and neck cancer refers to a diverse range of cancers with intricate molecular profiles that require individualised treatment strategies. Oncology is being revolutionised by precision medicine, which provides customised medicines based on unique tumour features. The aim of this review is to examine the state of precision medicine in head and neck cancer and its future prospects. Molecular profiling, biomarker-driven therapy, developing technologies, obstacles, and clinical consequences are highlighted. To compile the most recent research findings and trends in precision oncology for head a

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Rose, T. A. "Contemplation of head and neck intensity-modulated radiotherapy." Journal of Radiotherapy in Practice 7, no. 2 (2008): 61–66. http://dx.doi.org/10.1017/s1460396908006274.

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AbstractIntensity-modulated radiootherapy (IMRT) is being rapidly embraced as a radiotherapy technique in many cancer centres across the world. This paper aims to highlight the reported problems associated with the use of IMRT for the treatment of head and neck cancer. Specific areas of concern that are mentioned are the identification of tumour volumes, reproducibility of treatment, issues of tumour resistance and tumour recurrence. Radiotherapy departments are advised to make haste slowly when considering the implementation of this technique.

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Riaz, Umar, Hadia Wali, Shayan Shahid Ansari, Zujajah Hameed, and Muhammad Saqib. "A large, locally aggressive giant cell tumour arising from the laryngeal cartilage: A Rare Case Report." Journal of the Pakistan Medical Association 74, no. 6 (2024): 1167–71. http://dx.doi.org/10.47391/jpma.9173.

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Giant cell tumour is a growth predominantly found in long bones of the body. Giant cell tumour has a rare occurrence in the head and neck. A case of a 31 year old male with no known comorbidities at the ENT Department, Shifa International Hospital, Islamabad presented with anterior neck swelling and hoarseness of voice. Patient was diagnosed as having Giant Cell Tumour of Larynx (GTCL) proven on FNA cytology and post-operative biopsy. GCTL is an uncommon entity with only 45 reported cases in the world. Key Words: Giant Cell Tumor, Laryngeal Cancer, Thyroid Cartilage, Laryngectomy.

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Sandström, Karl, Ylva Tiblom Ehrsson, Felix Sellberg, Hemming Johansson, and Göran Laurell. "Loco-Regional Control and Sustained Difference in Serum Immune Protein Expression in Patients Treated for p16-Positive and p16-Negative Head and Neck Squamous Cell Carcinoma." International Journal of Molecular Sciences 24, no. 4 (2023): 3838. http://dx.doi.org/10.3390/ijms24043838.

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The main prognostic factors for patients with head and neck cancer are the tumour site and stage, yet immunological and metabolic factors are certainly important, although knowledge is still limited. Expression of the biomarker p16INK4a (p16) in oropharyngeal cancer tumour tissue is one of the few biomarkers for the diagnosis and prognosis of head and neck cancer. The association between p16 expression in the tumour and the systemic immune response in the blood compartment has not been established. This study aimed to assess whether there is a difference in serum immune protein expression prof

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Roland, N., G. Porter, B. Fish, and Z. Makura. "Tumour assessment and staging: United Kingdom National Multidisciplinary Guidelines." Journal of Laryngology & Otology 130, S2 (2016): S53—S58. http://dx.doi.org/10.1017/s002221511600044x.

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AbstractIn general, the first decision to be made in a patient with a confirmed head and neck cancer is whether or not to treat the patient before deciding what form of management strategy is appropriate. There is no more important an aspect of head and neck cancer care than the initial evaluation of the patient and the patient's tumour. The practice requires specific expertise and judgement. The current tumour–node–metastasis system relies on morphology of the tumour (anatomical site and extent of disease) but the final decision on treatment hinges on a full assessment of the patient includin

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El-Sharkawi, Salah. "Angiosarcoma of the head and neck." Journal of Laryngology & Otology 111, no. 2 (1997): 175–76. http://dx.doi.org/10.1017/s0022215100136771.

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AbstractAngiosarcoma of the head and neck is a rare tumour of vascular origin that affects the elderly. A 74-year-old man who presented with bruise-like macules of the scalp and face is reported. He was treated for a few months with different antibiotics and anti-allergic medication by his own family doctor, and referred for specialist opinion when he failed to derive any benefits from the medications. A biopsy was obtained from the lesion and proved to be an angiosarcoma. A review of the literature indicates that the most important prognostic factor in this particular disease is the size of t

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Alba, J. R., J. Basterra, J. C. Ferrer, F. Santonja, and E. Zapater. "Hypothyroidism in patients treated with radiotherapy for head and neck carcinoma: standardised long-term follow-up study." Journal of Laryngology & Otology 130, no. 5 (2016): 478–81. http://dx.doi.org/10.1017/s0022215116000967.

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AbstractObjective:Hypothyroidism is a common complication when radiotherapy is part of the treatment for head and neck tumours. This study aimed to show the incidence of hypothyroidism and possible risk factors in these patients.Methods:Factors related to the population, tumour, treatment and occurrence of hypothyroidism were analysed in 241 patients diagnosed with head and neck carcinoma.Results:Approximately 53 per cent of patients were diagnosed with radiation-induced hypothyroidism. Its occurrence was related to: tumour location, laryngeal surgery type, neck dissection type, post-operative

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Ayache, S., D. Chatelain, B. Tramier, and V. Strunski. "Oropharyngeal and hypopharyngeal myxoma: case report and literature review." Journal of Laryngology & Otology 121, no. 5 (2007): 1–4. http://dx.doi.org/10.1017/s002221510700669x.

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Objectives: To describe the features of an oropharyngeal and hypopharyngeal myxoma.Materials and methods: Case report of a 34-year-old patient operated upon for a dual-location tumour, and review of the literature.Results: The myxoma is a rare tumour. Various head and neck locations have been described, but not (to our knowledge) a tumour in both the oropharynx and the hypopharynx. Multiple synchronous locations must be searched for, particularly regarding cardiac myxoma.Conclusion: The myxoma is a rare, benign tumour, even rarer in the head and neck. Surgical treatment must be complete in ord

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de Bree, R., I. van der Waal, P. Doornaert, J. A. Werner, J. A. Castelijns, and C. R. Leemans. "Indications and extent of elective neck dissection in patients with early stage oral and oropharyngeal carcinoma: nationwide survey in The Netherlands." Journal of Laryngology & Otology 123, no. 8 (2009): 889–98. http://dx.doi.org/10.1017/s0022215109004800.

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AbstractBackground:Different strategies are available for the management of patients with early (i.e. tumour stage one or two) oral or oropharyngeal carcinoma and a clinically negative neck.Material and methods:In 2006, a questionnaire was sent to the eight head and neck cancer centres of the Dutch Head and Neck Oncology Cooperative Group. This questionnaire covered: the factors influencing the decision to perform an elective neck dissection; the neck staging procedure; and the types of neck dissection undertaken.Results:All eight questionnaires were returned completed. Respondents indicated t

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Har-El, Gady, Howard Y. Zirkin, Ferit Tovi, and Jack Sidi. "Congenital pleomorphic adenoma of the nasopharynx." Journal of Laryngology & Otology 99, no. 12 (1985): 1281–87. http://dx.doi.org/10.1017/s0022215100098546.

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AbstractA case of congenital salivary gland tumour occurring in the nasopharynx is reported. Congenital neoplasms of the head and neck (of any histological type) and congenital tumours of the nasopharynx are discussed and the literature is reviewed.

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Mohd Sabri, Mohd Naqib, Kasumawati Alli, Sze Yin Lam, Kharul Azmi Abdul Kadir, and Norafida Bahari. "RENAL CELL CARCINOMA WITH FACIAL SWELLING AND NASAL OBSTRUCTION AS PRIMARY PRESENTATION." Journal Of Cardiovascular, Neurovascular & Stroke 4, no. 2 (2022): 25–30. http://dx.doi.org/10.32896/cvns.v4n2.25-30.

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Background: Renal cell carcinoma (RCC) is a slow growing tumor. About 25–30% of patients are found to have metastases at diagnosis commonly to lung, liver and bones. The incidence of renal cell carcinoma metastasizing to the head and neck has been reported to range from 15-30%. Intranasal mass, or occasionally orbital mass maybe the presenting symptom of metastatic renal cell carcinoma to the nose and sinuses. Case presentation: We report a case of left RCC with large metastases to the frontonasal region producing head and neck symptoms before the primary lesion could be detected. Clinical pre

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Abhinav, Rathi, Jain Rachit, Verma Poonam, and Singh Anju. "The Impact of Surgical Techniques on Spinal Accessory Neuropathy: A Comparative Analysis of Neck Dissections at a Single Tertiary Care Center." International Journal of Pharmaceutical and Clinical Research 15, no. 9 (2023): 1184–88. https://doi.org/10.5281/zenodo.11373467.

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<strong>Background: </strong>In high-risk areas like India, head and neck cancers are a huge global health burden. Squamous cell carcinomas can develop in a variety of head and neck regions as a result of prolonged exposure to risk factors like alcohol, tobacco, and viral infections. Unique demographic and healthcare issues in India make it more difficult to manage this malignancy, including delayed diagnoses, poor access to care in rural areas, and side effects from treatment such shoulder weakness. By examining the effects of various neck dissection methods on spinal accessory neuropath

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Wollina, Uwe, André Koch, Gesina Hansel, Jacqueline Schönlebe, Torello Lotti, and Aleksandra Vojvodic. "Cutaneous Angiosarcoma of Head and Neck – A Single-Centre Analysis." Open Access Macedonian Journal of Medical Sciences 7, no. 18 (2019): 2976–78. http://dx.doi.org/10.3889/oamjms.2019.763.

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BACKGROUND: Cutaneous angiosarcoma of the head and neck region is a subtype of cutaneous angiosarcoma with an unfavourable prognosis. Diagnosis is often delayed. PATENTS AND METHODS: The setting is an Academic Teaching Hospital Skin Cancer Center. Eight Caucasian patients could be identified, 5 men and 3 women. Delay to diagnosis was between 12 to 4 months (mean 7.8 ± 2.9 months). The diagnosis was confirmed in all cases by histopathology and immunohistochemistry. Hematoxylin-eosin, Giemsa, PAS, iron and reticulin stains were performed. Endothelial markers such as CD31, CD34, and Ki67 fo

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Hossain, Mohammad Sowkat, S. M. Mahbubul Alam, Sk Md Jaynul Islam, Wasim Selimul Haque, and Shamoli Yasmin. "The role of immunohistochemistry for diagnosing undifferentiated malignancy in the head and neck region." BIRDEM Medical Journal 10, no. 1 (2019): 48–53. http://dx.doi.org/10.3329/birdem.v10i1.44760.

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Background: Undifferentiated tumours in the head and neck region are not uncommon. They can arise from different sites like in mucosa as well as in salivary glands, soft tissues or lymph nodes. Histopathological examination plays a central role in the diagnosis but difficulties arise with some tumours which are poorlydifferentiated due to their high inter- and intra-observer variability. In those cases, immunohistochemistry has greatly assisted to diagnose the tumours that cannot be accurately identified using routine histopathological procedures. The correct histopathological diagnosis is ess

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Singh, Bhuvanesh, Vladimir Santos, Thomas N. Guffin, Richard Alexis, and Gady Har-El. "Giant cell variant of malignant fibrous histiocytoma of the head and neck." Journal of Laryngology & Otology 105, no. 12 (1991): 1079–81. http://dx.doi.org/10.1017/s0022215100118249.

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AbstractThe giant cell variant of malignant fibrous histiocytoma is a rare entity in head and neck. Only eight well documented cases of this type are reported in the English literature. These tumours affect the superficial and deep structures of the neck most often and are best treated with prompt radical surgery. The prognosis of the giant cell type of malignant fibrous histiocytoma is dependent on the location of the tumour, with superficial tumours having a much better outlook.

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Chong, Vincent. "Tumour volume measurement in head and neck cancer." Cancer Imaging 7, Special Issue A (2007): S47—S49. http://dx.doi.org/10.1102/1470-7330.2007.9002.

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Álvarez Marcos, César Antonio, José Luis Llorente Pendás, Virginia Franco Gutiérrez, et al. "Tumour Recurrence in Squamous Head and Neck Cancer." Acta Otorrinolaringologica (English Edition) 58, no. 4 (2007): 156–63. http://dx.doi.org/10.1016/s2173-5735(07)70324-1.

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Garrel, R., D. Cupissol, and C. Alix-Panabieres. "Circulating tumour cells in head and neck cancer." European Annals of Otorhinolaryngology, Head and Neck Diseases 137, no. 3 (2020): 235. http://dx.doi.org/10.1016/j.anorl.2019.12.012.

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Harris, A. T., S. Derbyshire, J. Wilson, et al. "Circulating and disseminated tumour cells in head and neck cancer." Journal of Laryngology & Otology 129, no. 9 (2015): 826–30. http://dx.doi.org/10.1017/s0022215115001784.

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AbstractBackground:Multimodal treatment options in head and neck squamous cell carcinoma have allowed for greater control of locoregional disease, but this has not translated into a significant overall survival advantage for patients. This is partially because these treatment modalities have no influence over the rate of development of distant metastases.Objective:This article summarises the current methods of detecting circulating and disseminated tumour cells. It also discusses how these cells can offer prognostic value in head and neck squamous cell carcinoma, and considers questions posed

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Slevin, N. J., C. D. Collins, D. L. Hastings, et al. "The diagnostic value of positron emission tomography (PET) with radiolabelled fluorodeoxyglucose (18F-FDG) in head and neck cancer." Journal of Laryngology & Otology 113, no. 6 (1999): 548–54. http://dx.doi.org/10.1017/s0022215100144457.

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AbstractPositron emission tomography (PET) scanning has recently been introduced into clinical practice but its usefulness in the management of head and neck cancer is not well defined. The aim of this prospective preliminary study was to examine the clinical value of fluorodeoxyglucose (FDG) – PET in patients with head and neck cancer treated by radiotherapy with surgery in reserve by (i) relating quantitative uptake of isotope to tumour type and histological grade and (ii) comparing the imaging findings of PET and magnetic resonance imaging (MRI) in post-radiotherapy assessment of tumour res

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John, Keziah, Jennifer Wu, Bing-Wei Lee, and Camile S. Farah. "MicroRNAs in Head and Neck Cancer." International Journal of Dentistry 2013 (2013): 1–12. http://dx.doi.org/10.1155/2013/650218.

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microRNAs (miRs) are small noncoding single-stranded RNAs, about 19–25 nucleotides long. They have been shown to be capable of altering mRNA expression; thus some are oncogenic or tumour suppressive in nature and are regulated by cellular and epigenetic factors. The molecular pathogenic pathway of many cancers has been modified since the discovery of miRs. Head and neck squamous cell carcinoma (HNSCC), the sixth most common cancer in the world, has recently been associated with infection by the human papillomavirus (HPV). miR expression profiles are altered in the transition from dysplasia to

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