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Journal articles on the topic 'Head Recruiting'
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1
Budhy Prianto, Dwi Suharnoko, and Mardiyono. "The Recruitment Process of the Head of Local Government by Political Parties In Malang Raya Region." Journal Ilmu Sosial, Politik dan Pemerintahan 7, no. 2 (2021): 1–15. http://dx.doi.org/10.37304/jispar.v7i2.968.
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Direct regional head elections are in the process of recruiting leaders in regions that can guarantee the representation of local people through a democratic process. In this process, theoretically and constitutionally political parties have important and strategic roles and functions. Unfortunately, the oligarchic practice that engulfed almost all political parties has internally and externally recognized the basic principles of democracy in the process of recruiting prospective leaders in the region. The democratic process is only procedural, not substantial. So far it is strongly suspected that the process of regional head elections is more colored by transactional politics. This paper aims first, to obtain an overview of the recruitment process of candidates by political parties in the regional head elections in the Malang Raya region. Second, to obtain a description that is the power of money not only in choosing candidates for the regional head, but also able to lull constituents and voters in determining the choice of regional heads. Third, to obtain an explanation of the impact of the transactional political process and the use of the power of money as well as the impact on the relationship between political parties and their constituents in the Malang Raya region.
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MacMahon, Clare, Aisling Bailey, Morag Croser, and Juanita Weissensteiner. "Exploring the skill of recruiting in the Australian Football League." International Journal of Sports Science & Coaching 14, no. 1 (2018): 72–81. http://dx.doi.org/10.1177/1747954118809775.
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The present study was designed to explore the skill of recruiting in the professional Australian Football League, with a particular interest in the approach to decision making and information processing. The research design utilised semi-structured interviews and a survey instrument. A total of 12 participants comprised of 11 active head recruiters representing 11 Australian Football League Clubs, and one former expert Australian Football League recruiter undertook semi-structured, in-depth interviews to provide insight into recruitment decision making. Additionally, all participants completed a survey determining preferences for intuitive and deliberative decision-making styles. A model created represents the identification of four influential factors in the recruitment approach including (a) recruiter background; (b) recruiter attributes; (c) recruiter understanding of team needs and (d) recruiter–coach relationship. In particular, recruiters revealed that the style of decision making they use is influenced by the relationship with the head coach. Recruiting as a stand-alone position is not well understood. This work shows that both intuition and deliberation are used, the extent to which appears to be influenced by the recruiter–coach relationship. This work offers a strong base to further explore recruiting and talent identification in professional sport, and, particularly, how relationships influence decision style and performance.
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Prianto, Budhy, Dwi Suharnoko, and Mardiyono. "Political Parties and the Recruitment Process of Local Government Heads in Malang Raya." Journal of Public Administration and Governance 8, no. 4 (2018): 187. http://dx.doi.org/10.5296/jpag.v8i4.13966.
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Direct elections for the head of local government were a process of recruiting leaders in regions that can guarantee the representation of local people through a democratic process. In this process, theoretically and constitutionally political parties have important and strategic roles and functions. Unfortunately, the oligarchic practice that engulfed almost all political parties has internally and externally recognized the basic principles of democracy in the process of recruiting prospective leaders in the region. The democratic process is only procedural, not substantial. So far it is strongly suspected that the process of regional head elections is more colored by transactional politics. This paper aims first, to obtain an overview of the recruitment process for the local head government candidates by political parties in Malang Raya region. Second, to describe the power of money in choosing candidates by the parties and the voters. Third, to explain the transactional political impact on the performance of elected candidates. Methods were using descriptive analysis with qualitative approach and become parts of investigational report. Data were collected from interview and documentation. The results were consist of three aspects: first, at the stage of nomination of candidates for local head of government internally in political parties there was a tendency for friction between central and local political party leaders. In turn, this friction brought the failure of their candidate in the local election. Second, even though there were allegations of transactional politics between candidates for regional heads and political parties carrying them or between political parties, the allegations were not supported by concrete data. Third, the selection process for the head of local governments in the Malang Raya area tends to be less consistent with the performance of the government, especially those relating to PAD, IKF, and HDI.
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Najam, Sonia, Rukhman Solangi, Waheed Ali Umrani, and Sheraz Mustafa Rajput. "“Recruiting the right research associate for case research center”." Emerald Emerging Markets Case Studies 11, no. 1 (2021): 1–21. http://dx.doi.org/10.1108/eemcs-04-2020-0102.
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Learning outcomes After practicing the case students will be able to; understand the importance of recruiting the right person in retaining employees. Understand the underlying causes of employees’ turnover. Formulate retention strategies. Case overview/synopsis The case presents the situation of high turnover in Case Research Center (CRC), Sukkur IBA University. The protagonist, Dr. Waheed Ali Umrani, Head CRC was concerned about the retention of Research Associates in the CRC. The case also highlights the reasons for the turnover of early-career female research associates in an academic setup of Sukkur IBA University. This case will involve students to critically think and come up with retention strategies and measures that recruiters, in this case, should consider before and after the selection of Research Associates. Complexity academic level Graduate. Supplementary materials Teaching notes are available for educators only. Subject code CSS 6: Human Resource Management.
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Rathwell, Scott, Gordon A. Bloom, and Todd M. Loughead. "Head Coaches’ Perceptions on the Roles, Selection, and Development of the Assistant Coach." International Sport Coaching Journal 1, no. 1 (2014): 5–16. http://dx.doi.org/10.1123/iscj.2013-0008.
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The purpose of the study was to gain an in-depth understanding of the characteristics head coaches looked for when hiring their head assistant coach, the main roles and responsibilities assigned to assistants, and the techniques and behaviors used to develop them. Data were obtained through interviews with six accomplished Canadian University head football coaches. Results indicated head coaches hired loyal assistants who possessed extensive football knowledge that complimented their own skill sets. Once hired, head coaches had their assistant coaches help them with recruiting, managing a major team unit, and developing athletes. They helped advance their assistants’ careers through personal mentorships which included exposure to external sources of knowledge such as football camps and coaching conferences. These results represent one of the first empirical accounts of head coaches’ perceptions on hiring and developing head assistant coaches.
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Admon, Lindsay, Jessica K. Haefner, Giselle E. Kolenic, Tammy Chang, Matthew M. Davis, and Michelle H. Moniz. "Recruiting Pregnant Patients for Survey Research: A Head to Head Comparison of Social Media-Based Versus Clinic-Based Approaches." Journal of Medical Internet Research 18, no. 12 (2016): e326. http://dx.doi.org/10.2196/jmir.6593.
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Rifki, M. Saidi, and Mujaeni. "President, Kinship Politics, and Election 2019, and Its Influence on Regional Head Elections 2020 in Surakarta." Bestuurskunde: Journal of Governmental Studies 1, no. 1 (2021): 41–51. http://dx.doi.org/10.53013/bestuurskunde.1.1.41-51.
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This research departs from the victory of President Joko Widodo's son and son-in-law in the 2020 Regional Head Election. Approximately 44% or 55 candidates of the 124 regional head candidates who have a kinship with the authorities are confirmed to win the 2020 simultaneous Regional Head Election and stroll as regional heads. For this reason, this study will explore the phenomenon of winning candidates exposed to kinship politics, especially with the president in the 2020 Regional Head Election. This research also analyzes some of the causes of nepotism in the democratic system that are still visible in the 2020 simultaneous Regional Head Election. To achieve this goal, the research uses descriptive research methods with a qualitative approach. The method was chosen because the 2020 simultaneous Regional Head Election were multidimensional. The results of the study found several factors that led to kinship politics still coloring the 2020 Regional Head Election, including the advancement of candidates who were exposed to kinship with the president. These factors, such as the popularity of family names, are deliberately carried out by politicians as a way of inheriting power and the weak democratization of political parties, such as recruiting candidates for the regional head. This also led to candidates exposed to kinship with the president in striding to win the Regional Head Election. This research concludes that kinship should be able to lead to moral behavior, not just a pursuit of power. Concerning kinship politics, it can be controlled through internal reforms of political parties as institutions that carry out the role of candidate recruitment.
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Alger, Jackeline, Pierre Buekens, Maria Luisa Cafferata, et al. "Microcephaly Outcomes among Zika Virus–Infected Pregnant Women in Honduras." American Journal of Tropical Medicine and Hygiene 104, no. 5 (2021): 1737–40. http://dx.doi.org/10.4269/ajtmh.20-1483.
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ABSTRACTThe impact of Zika virus (ZIKV) infection on pregnancies shows regional variation emphasizing the importance of studies in different geographical areas. We conducted a prospective study in Tegucigalpa, Honduras, recruiting 668 pregnant women between July 20, 2016, and December 31, 2016. We performed Trioplex real-time reverse transcriptase–PCR (rRT-PCR) in 357 serum samples taken at the first prenatal visit. The presence of ZIKV was confirmed in seven pregnancies (7/357, 2.0%). Nine babies (1.6%) had microcephaly (head circumference more than two SDs below the mean), including two (0.3%) with severe microcephaly (head circumference [HC] more than three SDs below the mean). The mothers of both babies with severe microcephaly had evidence of ZIKV infection. A positive ZIKV Trioplex rRT-PCR was associated with a 33.3% (95% CI: 4.3–77.7%) risk of HC more than three SDs below the mean.
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Douglas, Scott, William R. Falcão, and Gordon A. Bloom. "Career Development and Learning Pathways of Paralympic Coaches With a Disability." Adapted Physical Activity Quarterly 35, no. 1 (2018): 93–110. http://dx.doi.org/10.1123/apaq.2017-0010.
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The purpose of this study was to gain an understanding of the career development and learning pathways of Paralympic head coaches who previously competed as Paralympic athletes. Each coach participated in a semistructured interview. A thematic analysis of the data revealed three higher order themes, which were called becoming a coach, learning to coach, and lifelong learning and teaching. Across these themes, participants discussed interactions with other coaches and athletes with a disability, learning from mentors and coaching clinics, as well as limited formal educational opportunities they experienced transitioning from athlete to head coach. The findings revealed that they acquired most of their knowledge from a combination of knowledge gained as athletes and informal sources, including trial and error. They also stressed the need for enhanced recruiting of parasport coaches and parasport coach education opportunities that would enhance programs for athletes with physical disabilities, from grassroots to Paralympic levels.
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Kiraly, Meredith. "The problem of the paedophile: guidelines for recruiting staff for positions in child and youth care." Children Australia 21, no. 2 (1996): 35–37. http://dx.doi.org/10.1017/s1035077200007057.
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In recent years there has been widespread concern across the English-speaking world about repeated incidents in which paedophiles have obtained positions of responsibility in relation to the care of vulnerable children, such as those living in residential care. In the United Kingdom, a series of well-publicised incidents over several years culminated in the Beck case. Frank Beck was a paedophile who was appointed to the position of head of a children's home. Following the discovery of his abusive activities with children in one workplace, he successfully moved to a similar position of responsibility. In response to this series of scandals an inquiry was set up in to the Selection, Development and Management of Staff in Children's Homes (the Warner Inquiry). This inquiry produced a substantial report on ways in which selection and management practices should be improved. There have, however, been continuing concerns that international paedophile rings continue to pose a significant risk to children and young people in the care system across the world.
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Scholfield, Daniel W., Dorothy M. Gujral, and Zaid Awad. "Transoral Robotic Surgery for Oropharyngeal Squamous Cell Carcinoma: Improving Function While Maintaining Oncologic Outcome." Otolaryngology–Head and Neck Surgery 162, no. 3 (2020): 267–68. http://dx.doi.org/10.1177/0194599820902043.
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The improved survival in patients with HPV-positive (human papilloma virus) oropharyngeal squamous cell carcinoma as compared with HPV-negative disease calls for treatment that preserves quality of life, particularly a functional swallow. There are several trials currently assessing treatment de-escalation in terms of less invasive transoral robotic surgery, reduced-dose radiotherapy, and omission of chemotherapy in this disease cohort. It is important for head and neck oncology surgeons to stay abreast of developments in this area to offer their patients the most up-to-date treatment and consider recruiting patients to trials at their institutions. For this purpose, we provide a summary of current trials and associated challenges in managing a disease with fast-evolving treatment algorithms.
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Seymour, Matthew T., Rachel Moser, Matthew Cooper, Sheila Fisher, Karen Poole, and Christopher Nutting. "Growth in head and neck cancer clinical research in the NCRN and NCRI: Expanding opportunities for patients across the United Kingdom." Journal of Clinical Oncology 30, no. 15_suppl (2012): e16007-e16007. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e16007.
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e16007 Background: The National Institute for Health Research Cancer Research Network (NCRN) was established in 2001 to benefit patients by improving the coordination, integration and speed of cancer research. Networks were established in England (NCRN), Scotland, Wales and Northern Ireland, supporting recruitment to a national portfolio across the NHS. In a decade recruitment to cancer studies has increased five fold in England to 20% of new incident cases. Head and Neck cancers affect basic functions including breathing and eating; particularly devastating for patients. The NCRI Head and Neck Cancer Clinical Studies Group is one of 23 Groups funded by NCRI members with a UK wide remit to develop a national portfolio of clinical studies. All CSGs include patients and carers as members resulting in active patient involvement in trial design, patient information and strategic direction of the portfolio. Methods: The last decade has seen unprecedented growth in the Head and Neck portfolio, which now includes 43 studies from only three studies in 2003/4. By 2010/11, 95% of UK Cancer Local Research Networks (37 networks) were recruiting to Head and Neck studies from only 2 networks in 2001/2, expanding trial access for patients and developing Head and Neck research expertise in new sites and with new investigators. Results: Numbers of patients participating in Head and Neck studies has grown exponentially. Since 2006/7 UK patient recruitment has risen 15-fold from 126 to 1890, representing almost 25% new incident cases of Head and Neck cancer. Conclusions: Rapid portfolio growth and associated network activity has expanded opportunities for patients with Head and Neck cancer; providing access to new therapeutic agents and treatment modalities, including NIHR CRN-adopted commercial trials and studies in a surgical setting. Participation in studies demonstrating the effectiveness of Intensity Modulated Radiotherapy in reducing xerostomia (including PARSPORT), has supported integration of this technique into cancer service.
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Komarova, Yulia A., Anna S. Akhmanova, Shin-ichiro Kojima, Niels Galjart, and Gary G. Borisy. "Cytoplasmic linker proteins promote microtubule rescue in vivo." Journal of Cell Biology 159, no. 4 (2002): 589–99. http://dx.doi.org/10.1083/jcb.200208058.
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The role of plus end–tracking proteins in regulating microtubule (MT) dynamics was investigated by expressing a dominant negative mutant that removed endogenous cytoplasmic linker proteins (CLIPs) from MT plus ends. In control CHO cells, MTs exhibited asymmetric behavior: MTs persistently grew toward the plasma membrane and displayed frequent fluctuations of length near the cell periphery. In the absence of CLIPs, the microtubule rescue frequency was reduced by sevenfold. MT behavior became symmetrical, consisting of persistent growth and persistent shortening. Removal of CLIPs also caused loss of p150Glued but not CLIP-associating protein (CLASP2) or EB1. This result raised the possibility that the change in dynamics was a result of the loss of either CLIPs or p150Glued. To distinguish between these possibilities, we performed rescue experiments. Normal MT dynamics were restored by expression of the CLIP-170 head domain, but p150Glued was not recruited back to MT plus ends. Expression of p150Glued head domain only partially restored MT dynamics. We conclude that the CLIP head domain is sufficient to alter MT dynamics either by itself serving as a rescue factor or indirectly by recruiting a rescue factor. By promoting a high rescue frequency, CLIPs provide a mechanism by which MT plus ends may be concentrated near the cell margin.
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Darwis, Darwis, and Sasterio Sasterio. "Identity as a Means of Recruitment for Political Parties and the Influence of Leaders in Sigi Regency, Central Sulawesi Province." International Journal Papier Public Review 2, no. 2 (2021): 27–35. http://dx.doi.org/10.47667/ijppr.v2i2.86.
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 This article explains how the means of recruiting political parties in finding candidates for regional head in Sigi Regency. And how role models can influence the way people think in choosing. This study uses a qualitative method, by collecting data in the form of statements, behaviors and events through the use of observation methods, in-depth interviews, focus discussion groups, and searching for complementary materials from document data obtained to be analyzed as a relevant unit of information based on this research study. The results showed that even though the candidates were nominated by political partie the election 2015 in Sigi Regency, the candidates still represented their communities based on their religious identity. Each candidate for regional head who does not meet the qualifications or does not pass the administrative selection at the General Election Commissions of Sigi Regency each has a distinctive feature, namely a religious identity. The people of Sigi Regency seem to be more interested in the figures who will run for themselves than the political parties that carry them.
 
 
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Berry, Jill, and Andrew Townsend. "Peter’s Transition to Headship: What Can We Learn From His Experience About How to Prepare to Make the Transition From Assistant Principal, or Deputy, to Principal or Head Teacher?" Journal of Cases in Educational Leadership 22, no. 3 (2019): 28–42. http://dx.doi.org/10.1177/1555458919848131.
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The transition for new head teachers (school principals) can be a difficult and unpredictable one. This article outlines a case of a deputy (assistant principal) in the United Kingdom as he takes up his first headship. We describe some of the challenges involved and prompt readers to consider strategies that could be used and support that may be accessed to negotiate this challenging period. In particular, this illustrative case shows how the lead-in period between appointment and formal assumption of the role can be productively used. This article would be of use to readers aspiring to take on a senior leadership roles. But it would also be relevant for people working at district level and others involved in recruiting, appointing, and supporting senior leaders.
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Rezvani, Sam, and Brian D. Corneil. "Recruitment of a Head-Turning Synergy by Low-Frequency Activity in the Primate Superior Colliculus." Journal of Neurophysiology 100, no. 1 (2008): 397–411. http://dx.doi.org/10.1152/jn.90223.2008.
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Low-frequency activity within the oculomotor system helps bridge sensation and action. Given ocular stability, low-frequency activity sustained by some neurons within the intermediate and deep superior colliculus (dSC) is assumed to be separated from motor output. However, the dSC is an orienting structure and the influence of low-frequency dSC activity at other effectors remains untested. We studied this by simultaneously recording activity from saccade-related dSC neurons and electromyographic (EMG) activity from neck muscles that turn the head. Monkeys performed a gap-saccade paradigm with varying levels of reward expectancy. Despite head restraint and even for relatively small target eccentricities (≤10°), increasing reward expectancy for a given target increased the level of low-frequency activity on dSC neurons encoding saccades to the rewarded target and increased the recruitment of a neck muscle synergy that would turn the head toward the target. The magnitude of neck muscle recruitment correlated positively on a trial-by-trial basis with the level of low-frequency dSC activity, and such correlations were optimized when neck muscle activity was shifted about 20 ms later to account for delays in the tecto-reticulo-spinal pathway. Further, dSC activity discriminated about the side of target presentation approximately 11 ms earlier than neck EMG activity. Considered alongside neck EMG responses evoked causally by SC stimulation, our results are consistent with low-frequency dSC activity recruiting a head-turning synergy. Our results support a brain stem circuit wherein the magnitude of neck muscle recruitment reflects the difference in comparative low-frequency activation across both dSCs, perhaps because of mutually inhibitory interactions within downstream head premotor circuits.
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de Wit, K., H. Minas, W. Arthur, et al. "LO47: Incidence of intracranial bleeding in anticoagulated emergency patients with minor head injury: a meta-analysis." CJEM 20, S1 (2018): S23. http://dx.doi.org/10.1017/cem.2018.109.
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Introduction: The proportion of Canadians receiving anticoagulation medication is increasing. Falls in the elderly are the most common cause of minor head injury and an increasing proportion of these patients are prescribed anticoagulation. Emergency department (ED) guidelines advise performing a CT head scan for all anticoagulated head injured patients, but the risk of intracranial hemorrhage (ICH) after a minor head injury (patients who have a Glasgow comma score (GSC) of 15) is unclear. We conducted a systematic review and meta-analysis to determine the point incidence of ICH in anticoagulated ED patients presenting with a minor head injury. Methods: We systematically searched Pubmed, EMBASE, Cochrane database, DARE, google scholar and conference abstracts (May 2017). Experts were contacted. Meta-Analyses and Systematic Reviews of Observational Studies (MOOSE) guidelines were followed with two authors reviewing titles, four authors reviewing full text and four authors performing data extraction. We included all prospective studies recruiting consecutive anticoagulated ED patients presenting with a head injury. We obtained additional data from the authors of the included studies on the subset of GCS 15 patients. We performed a meta-analysis to estimate the point incidence of ICH among patients with a GCS score of 15 using a random effects model. Results: A total of five studies (and 4,080 GCS 15, anticoagulated patients) from the Netherlands, Italy, France, USA and UK were included in the analysis. One study contributed 2,871 patients. Direct oral anticoagulants were prescribed in only 60 (1.5%) patients. There was significant heterogeneity between studies with regards to mechanism of injury, CT scanning and follow up method (I2 =93%). The random effects pooled incidence of ICH was 8.9% (95% CI 5.0-13.8%). Conclusion: We found little data to reflect contemporary anticoagulant prescribing practice. Around 9% of warfarinized patients with a minor head injury develop ICH. Future studies should evaluate the safety of selective CT head scanning in this population.
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Pazqara, Emiraldo Win. "MEKANISME REKRUITMEN CALON BUPATI DALAM PEMILIHAN UMUM KEPALA DAERAH SECARA LANGSUNG TAHUN 2015 DI KABUPATEN LAMPUNG SELATAN." INTAJ : Jurnal Penelitian Ilmiah 2, no. 01 (2018): 45–69. http://dx.doi.org/10.35897/intaj.v2i01.110.
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The purpose of this research was to know the recruitment process performed by National Mandate Party in recruiting Government Regent candidate in the general election of district head directly in South Lampung at 2015. Method used in this research was qualitative experiment method with interactive analysis. Result of the research based on interview, observed documentation files, and the rule of law as guided in recruitment process by National Mandate Party South Lampung, showed that recruitment process at National Mandate Party was open with several indicators: (1) open candidacy for public in other words there is no party cadre monopoly; (2) several candidates were socialized in order to get response and idea from public; (3) selected candidates were established through convention democratically and can be accepted by society.
 Keywords: Recruitment, Government Regent, South Lampung
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Febrian, Kurnia Rifqi, Dwian Hartomi Akta Padma Eldo, and Sakir Sakir. "IMPLEMENTATION OF LOCAL REGULATIONS NUMBER 5 2016 IN BANTUL." Jurnal Ilmiah Wahana Bhakti Praja 7, no. 1 (2017): 27. http://dx.doi.org/10.33701/jiwbp.v7i1.67.
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ABSTRACT Bantul local regulation number 5 of 2016 about village official has already explained the detail of recruitment mechanism of village servant in Bantul district. This regulation aims to become guidance for head of village that in recruiting village servant it is not directly appointed by village head anymore yet through open selection system by which public can participate.This research employs two methods; First, observation. Second, interview with selection committee of Tirtonurmolo village and the third party—academicians—who were directly involved in the selection. This research aims to explore how extend the local regulation has worked in each village in Bantul district. The selected village to be reviewed is Tirtonirmolo village that has just finished its village servant selection in 2016.Tirtonirmolo is one of villages in Bantul district that has openly conducted village servant selection in 2016. The selection aims to fill some positions; village secretary and head of governmental affair. The applicants were very enthusiastic in which the test was followed by both young man and woman and adult from various education backgrounds. Generally, the majority of the applicants were Tirtonirmolo resident yet there were several applicants from other village.This open selection is a manifestation of Good Local Governance in which transparancy and accountability is prefered in the process—start from the begin until the announcement of the result. During the selection, the committee involved third party—academician from university. By this selection last year, the position of village secretary and head of governmental affair is now filled by competent human resource in its field.
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Dawson, Russell D., and Robert G. Clark. "Effects of Hatching Date and Egg Size on Growth, Recruitment, and Adult Size of Lesser Scaup." Condor 102, no. 4 (2000): 930–35. http://dx.doi.org/10.1093/condor/102.4.930.
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AbstractEvidence suggests that birds breeding early in the season or laying larger eggs are at a selective advantage because quality and survival of their offspring are higher. We tested whether wild Lesser Scaup (Aythya affinis) hatching early in the season or from larger eggs had enhanced growth as ducklings and larger size or higher probability of recruiting to the local breeding population in years after hatching. After correcting for age at capture, body mass, head length, and culmen of ducklings were inversely related to hatching date, but were unrelated to egg volume. As adults, late-hatched birds had shorter wing lengths (second-year birds only) and tended to have smaller head lengths (all after-hatch year birds) than early hatching birds. We suggest that later-hatching birds are smaller due to increased competition for food during brood rearing. Recruitment probability increased as natal egg volume increased and decreased among birds with later natal hatching dates. We speculate these results are due to higher mortality of ducklings hatched from small eggs, and because early-hatched birds have more time to acquire nutrient reserves that would reduce vulnerability to costs of migration.
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Chen, Yi-Hsun, Yao-Kuang Wang, Yun-Shiuan Chuang, et al. "Endoscopic Surveillance for Metachronous Esophageal Squamous Cell Neoplasms among Head and Neck Cancer Patients." Cancers 12, no. 12 (2020): 3832. http://dx.doi.org/10.3390/cancers12123832.
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Esophageal squamous cell neoplasms (ESCNs) are the most common second primary neoplasm in patients with head and neck squamous cell carcinoma (HNSCC), and few studies have focused on metachronous ESCNs. We aimed to evaluate the incidence of and risk factors for metachronous ESCNs and to provide a reasonable endoscopic follow-up plan for HNSCC patients. We extended our prospective cohort since October 2008 by recruiting incident HNSCC patients. All enrolled patients were interviewed to collect information on substance use (smoking, alcohol, and betel nut) and esophagogastroduodenoscopy (EGD) with Lugol chromoendoscopy results for synchronous ESCNs soon after HNSCC diagnosis. Endoscopic screenings for metachronous ESCNs were performed 6 to 12 months after the previous examinations. A total of 1042 incident HNSCC patients were enrolled, but only 175 patients met all the criteria and were analyzed. A total of 20 patients had metachronous ESCNs (20/175, 11.4%). Only the initial Lugol-voiding lesion (LVL) classification significantly predicted the development of metachronous ESCNs. Patients with an LVL classification of C/D had a higher risk of developing metachronous ESCNs than those with an LVL classification of A/B (adjusted odds ratio: 5.03, 95% confidence interval: 1.52–16.67). The mean interval for developing metachronous ESCNs was 33 months, but the shortest interval for developing metachronous esophageal squamous cell carcinoma was 12 months. Lugol chromoendoscopy screening among incident HNSCC patients predicts the risk of developing metachronous ESCNs. A closer follow-up with an endoscopy every 6 months is recommended for those with LVL classifications of C and D.
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Dunn, Janet A., Raghav Kulkarni, David Gouldesbrough, et al. "LIHNCS trial: Lugol's iodine in head and neck cancer surgery." Journal of Clinical Oncology 30, no. 15_suppl (2012): e16042-e16042. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e16042.
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e16042 Background: Residual dysplasia at margins of mucosal tumour resection is a cause of disease failure. While risk of transformation of dysplasia is difficult to assess, malignant cells within a field of dysplastic change indicate high transformation potential of this dysplastic field. Lugol's iodine assists in the assessment of surgical margins at tumour resection to ensure removal of margin dysplasia where present and resectable using the surrogate biomarker of glycogen storage. This multicenter RCT assesses efficacy of this technique in head and neck cancer surgery and is recruiting over the next two years. Methods: Patients undergoing primary surgery for oral cavity and oropharynx squamous carcinoma are randomised to gold standard surgical resection or to resection guided by Lugol's iodine application. Mucosal surfaces are irrigated with saline, carbocisteine solution applied to remove surface mucus and then irrigated with Lugol's iodine solution. Where present, adjacent visible surface dyplasia is resected with the tumour specimen. Histopathologists are blinded to the technique used. Histopathology is repeated centrally for quality control. Margin status is assessed for involved, close and clear for carcinoma and for presence of dysplasia at margins. Quality of life data are collected at baseline, six weeks, six, twelve and 24 months. Results: Our cohort study of 100 cases showed a reduction in margin dyplasia from 32% to 4% p<0.001. A feasibility pilot trial recruited 98 patients with 100% consent and data collection rates. Recruitment is progressing on schedule and at time of writing two sites are open. Forty six patients have consented in four sites and are included in the trial to date. A further 12 sites are in the trial set up process. We will report our interim data regarding sites open, screened and consented rates and outcomes so far. Conclusions: To date recruitment is on schedule. We have demonstrated the acceptability of the trial and techniques therein to both patients and surgeons. This is a promising technique which may modify head and neck cancer surgery by targeting dysplasia for inclusion at time of resection of primary cancer. Thus locoregional recurrence may be reduced in a proportion of patients undergoing curative surgical resection.
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Fajarwati, Lia, Rachmat Hidayat, and Yusnia Budiarti. "Sistem Informasi Rekrutmen Karyawan Baru pada PT Karya Putra Sapta Manunggal Berbasis Web." Jurnal Teknologi Sistem Informasi dan Aplikasi 3, no. 4 (2020): 237. http://dx.doi.org/10.32493/jtsi.v3i4.7468.
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PT Karya Putra Sapta Manunggal is a company in the field of construction services based in Bekasi. In recruiting employees, PT Karya Putra Sapta Manunggal still uses conventional methods, namely that prospective employees usually send application files to the head office in Bekasi either by e-mail, post or by submitting applications directly to the Admin section. HRDs need to open e-mails and application files one by one which makes HRDs have to process applicants' data again, resulting in a high probability of errors. Therefore, it is necessary to create a new and effective system in order to facilitate the recruitment of employees using a system development methodology, namely the waterfall method. With the PHP programming language, codeigniter framework and mysql database, the employee recruitment website makes it easier for HRD to minimize time, costs and energy so that the recruitment process becomes more efficient. In addition, delivering clear and up-to-date information will improve the company's image.
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Puri, Anu, Peter Hug, Kristine Jernigan, Patrick Rose, and Robert Blumenthal. "Role of Glycosphingolipids in HIV-1 Entry: Requirement of Globotriosylceramide (Gb3) in CD4/CXCR4-dependent Fusion." Bioscience Reports 19, no. 4 (1999): 317–25. http://dx.doi.org/10.1023/a:1020554509642.
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We have recently shown that addition of human erythrocyte glycosphingolipids (GSL) to non-human CD4+ or GSL-depleted human CD4+ cells rendered those cells susceptible to gp120-gp41-mediated cell fusion (Puri et al., BBRC, 1998). One GSL fraction (Fraction 3) isolated from human erythrocyte GSL mixture exhibited the highest recovery of fusion following incorporation into CD4+ non-human and GSL-depleted HeLa-CD4 cells (HeLa-CD4/GSL-). Structural analysis of Fraction 3 showed that this GSL had identical head group as the known GSL, Gal(α1→4)Gal(β1→4)Glc-Ceramide (Gb3) (Puri et al., PNAS, 1998). Here we report that presence of Gb3 in CD4+/CXCR4+ cells but not CD4+/CXCR4- cells allows fusion with HIV-1Lai-envelope glycoprotein expressing cells (TF228). Therefore, Gb3 functions in conjunction with HIV-1 co-receptor, CXCR4 to promote fusion. We propose that Gb3 functions by recruiting CD4 and/or CXCR4 at the fusion site through structurally specific interactions.
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Dixon, Marlene A., and Stacy Warner. "Employee Satisfaction in Sport: Development of a Multi-Dimensional Model in Coaching." Journal of Sport Management 24, no. 2 (2010): 139–68. http://dx.doi.org/10.1123/jsm.24.2.139.
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Despite the overwhelming emphasis on job satisfaction in sport management research, scholars continue to advocate for the distinctiveness and importance of evaluating both job satisfaction and dissatisfaction. The purpose of this investigation is to develop a model of job satisfaction and dissatisfaction for intercollegiate coaches. Fifteen head coaches participated in semistructured interviews. Results revealed a sport industry specific three-factor model. Desirable job factors (Player-Coach Relationships, Recognition, and Social Status) were related only to satisfaction. Industry Standard Factors (Sport Policy, Salary, Recruiting, Supervision, and Life Balance) were related only to dissatisfaction. Performance Dependent Factors (Flexibility and Control, Program Building, and Relationships with Colleagues) were related to satisfaction and dissatisfaction. The results support the distinctiveness of job satisfaction and dissatisfaction as constructs, and also demonstrate a continued need for examining job attitudes within context. As sport managers understand the particular expectations of their employees and their industry they can better diagnose and solve employee issues.
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Tapia-Rojo, Rafael, Álvaro Alonso-Caballero, and Julio M. Fernández. "Talin folding as the tuning fork of cellular mechanotransduction." Proceedings of the National Academy of Sciences 117, no. 35 (2020): 21346–53. http://dx.doi.org/10.1073/pnas.2004091117.
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Cells continually sample their mechanical environment using exquisite force sensors such as talin, whose folding status triggers mechanotransduction pathways by recruiting binding partners. Mechanical signals in biology change quickly over time and are often embedded in noise; however, the mechanics of force-sensing proteins have only been tested using simple force protocols, such as constant or ramped forces. Here, using our magnetic tape head tweezers design, we measure the folding dynamics of single talin proteins in response to external mechanical noise and cyclic force perturbations. Our experiments demonstrate that talin filters out external mechanical noise but detects periodic force signals over a finely tuned frequency range. Hence, talin operates as a mechanical band-pass filter, able to read and interpret frequency-dependent mechanical information through its folding dynamics. We describe our observations in the context of stochastic resonance, which we propose as a mechanism by which mechanosensing proteins could respond accurately to force signals in the naturally noisy biological environment.
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Kirkley, Richard Bruce. "John Hirsch and the Critical Mass: Alternative Theatre on CBC Television in the 1970s." Theatre Research in Canada 15, no. 1 (1994): 75–95. http://dx.doi.org/10.3138/tric.15.1.75.
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This article examines John Hirsch's attempts to bring Canadian theatre artists and stage plays to television during his tenure, as Head of CBC English Language Television Drama in the 1970s. When the CBC appointed John Hirsch, they gave him a strong mandate to strengthen the drama department's relationship with Canadian theatre by bringing some of the best plays and performances to television, and by recruiting new talent from the theatre. To fulfill this mandate, Hirsch initiated a bold, comprehensive strategy; yet a series of historical forces, ranging from financial and economic to cultural and aesthetic, made the full realization of his strategy very difficult. By examining the problems that confronted Hirsch's theatre projects, this article will show how historical circumstances specific to the 1970s impeded the success of the projects, and will further suggest that more recent technological, structural and cultural developments related to television production and reception may have generated an environment more conducive to the achievement of successful collaborations between theatre and television.
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Ellebedy, Ali H., Raffael Nachbagauer, Katherine J. L. Jackson, et al. "Adjuvanted H5N1 influenza vaccine enhances both cross-reactive memory B cell and strain-specific naive B cell responses in humans." Proceedings of the National Academy of Sciences 117, no. 30 (2020): 17957–64. http://dx.doi.org/10.1073/pnas.1906613117.
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There is a need for improved influenza vaccines. In this study we compared the antibody responses in humans after vaccination with an AS03-adjuvanted versus nonadjuvanted H5N1 avian influenza virus inactivated vaccine. Healthy young adults received two doses of either formulation 3 wk apart. We found that AS03 significantly enhanced H5 hemagglutinin (HA)-specific plasmablast and antibody responses compared to the nonadjuvanted vaccine. Plasmablast response after the first immunization was exclusively directed to the conserved HA stem region and came from memory B cells. Monoclonal antibodies (mAbs) derived from these plasmablasts had high levels of somatic hypermutation (SHM) and recognized the HA stem region of multiple influenza virus subtypes. Second immunization induced a plasmablast response to the highly variable HA head region. mAbs derived from these plasmablasts exhibited minimal SHM (naive B cell origin) and largely recognized the HA head region of the immunizing H5N1 strain. Interestingly, the antibody response to H5 HA stem region was much lower after the second immunization, and this suppression was most likely due to blocking of these epitopes by stem-specific antibodies induced by the first immunization. Taken together, these findings show that an adjuvanted influenza vaccine can substantially increase antibody responses in humans by effectively recruiting preexisting memory B cells as well as naive B cells into the response. In addition, we show that high levels of preexisting antibody can have a negative effect on boosting. These findings have implications toward the development of a universal influenza vaccine.
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Pangastuti, Fitri, Prihastiwi Utari, and Agung Satyawan. "Negotiation of Female Information Integration in Choosing Leaders (Case Study of Information Integration of Muslimat NU in Choosing Khofifah Indar Parawangsa as Governor of East Java in Magetan)." International Journal of Multicultural and Multireligious Understanding 8, no. 3 (2021): 131. http://dx.doi.org/10.18415/ijmmu.v8i3.2396.
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Politics and women are the main discourse now never ending. Politics as an instrument for recruiting leaders must deal with various factors, including from a religious perspective. Among the jurists, it is almost agreed that a woman is not allowed or prohibited to become a head of state, because she is identical to an imam or caliph. The prohibition of women from becoming heads of state is a hadith narrated by Imam Bukhari from Abu Bakrah; Prophet SAW. said when he heard that the Persians adopted the daughter Kisra after her death as ruler. "It will never be fortunate for a people to hand over their power (government) to a woman". Islamic Sharia is very clearly stated in the Al Quran. Islam does not allow public leadership, such as: president, governor, regent or the like are held by women based on various arguments mentioned in the Qur'an and sunnah including the letter an Nisa which means "Men are men. is a leader for women? ". The above argument strongly emphasizes that women do not have the slightest opportunity as leaders, even within the scope of regional heads. In addition, the identity of women's communication in politics is still based on the stigma of ascribed status not because of Achievement status. However, the election of Khofifah Indar Parawangsa, whose knowledge is that she is a woman is contrary to this argument. In fact, he was able to be elected Governor of East Java and was able to be accepted by Muslimat NU, especially in the Magetan area. This makes the author want to further investigate the phenomenon that occurs. The research was conducted using qualitative research, namely research procedures that produce descriptive data in the form of words written or spoken from people and observable behavior. According to the research, it was found that in the negotiation of women's information integration in choosing leaders, there were valence and assessment weights.
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Barbaros, Maria Corina. "Does employer branding beat head hunting? The potential of company culture to increase employer attractiveness." Journal of Entrepreneurship, Management and Innovation 16, no. 4 (2020): 87–112. http://dx.doi.org/10.7341/20201643.
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This paper aims to investigate the combined effort of the HR Department and the Marketing and Communication Department to define and implement employer-branding strategies. To obtain the aim, qualitative research was designed to establish the relationship between employer attractiveness, organizational attractiveness and company culture, and to identify to what extent company culture can be communicated through employer branding. Therefore, firstly, the study clarifies the links between employer branding, employer attractiveness, company culture, and the boundaries of these concepts. It then examines how employer branding works concerning company culture attributes, and, finally, the paper draws some conclusions that will address practical implications in the form of employer brand management. The research design was based on qualitative research methods (in-depth interviews and focus groups) applied to stakeholders, employees from the IT industry, and IT companies’ representatives. Subsequently, the qualitative data were processed with Atlas.ti 8 that generated the results and the points under discussion. The data show that when recruiting strategies, respectively, employer-branding strategies are thought separately, as happens most of the time, their efficiency diminishes considerably, and the employer image does not have consistency and attractiveness. To conclude, this study highlights the following practical ideas: a)management teams must have a holistic approach of employer branding, organizational attractiveness, and company culture; b)employer branding, in order to become a useful tool for employees’ retention and recruitment, must be managed by both the HR Department and the Marketing and Communication Department within a coordinated and coherent strategy and c) for employer branding to be efficient, there is a need to leverage HR as a strategic partner and, as a result, employees will be developed into strategic assets of the company.
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Oldenburg, Christian, Anders Lundin, Gunnar Edman, Catharina Nygren Deboussard, and Aniko Bartfai. "Emotional reserve and prolonged post-concussive symptoms and disability: a Swedish prospective 1-year mild traumatic brain injury cohort study." BMJ Open 8, no. 7 (2018): e020884. http://dx.doi.org/10.1136/bmjopen-2017-020884.
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ObjectiveProlonged post-concussive symptoms (PCS) affect a significant minority of patients withmild traumatic brain injury (mTBI). The aetiology is multifactorial depending on preinjury as well as peri-injury and postinjury factors. In this study, we examine outcome from an emotional reserve perspective.DesignProspective cohort study.SettingPatients were recruited from three emergency departments in major university hospitals in Stockholm, Sweden. Follow-up data were collected in an outpatient setting at one of the recruiting hospitals.Participants122 patients with a history of blunt head trauma (aged 15–65 years; admitted for mTBI within 24 hours after trauma (Glasgow Coma Scale score of 14–15, loss of consciousness <30 min and/or post-traumatic amnesia <24 hours). Exclusion criteria were other significant physical injury and other major neurological disorder, including previous significant head injury.ProcedureRecruitment in three emergency departments. Initial assessments were made within 1 week after the injury. Patients were mailed the follow-up questionnaires 1 year postinjury.Outcome measuresA psychiatric assessment was performed at 1 week post injury. The participants also completed a personality inventory, measures of psychological resilience, depression, anxiety and post-traumatic symptoms. One-year outcome was measured by the Rivermead Post Concussion Symptoms and the Rivermead Head Injury Follow-Up questionnaires.ResultsThe psychiatric assessment revealed more symptoms of anxiety, depression and post-traumatic symptoms in the acute stage for patients who later developed PCS.After 1 year, 94 participants were still in the programme (male/female 57/37) and 12% matched the extended criteria for PCS (≥3 symptoms and ≥2 disabilities). PCS patients reported more preinjury and concurrent psychiatric problems, lower level of functioning before the injury and experienced more stress. They showed higher somatic trait anxiety, embitterment, mistrust and lower level of psychological resilience than recovered participants.ConclusionIntrapersonal emotional reserve shape the emergence and persistence of PCS after mTBI.
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Weston, Andrea D., Bruce Blumberg, and T. Michael Underhill. "Active repression by unliganded retinoid receptors in development." Journal of Cell Biology 161, no. 2 (2003): 223–28. http://dx.doi.org/10.1083/jcb.200211117.
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The retinoid receptors have major roles throughout development, even in the absence of ligand. Here, we summarize an emerging theme whereby gene repression, mediated by unliganded retinoid receptors, can dictate cell fate. In addition to activating transcription, retinoid receptors actively repress gene transcription by recruiting cofactors that promote chromatin compaction. Two developmental processes for which gene silencing by the retinoid receptors is essential are head formation in Xenopus and skeletal development in the mouse. Inappropriate repression, by oncogenic retinoic acid (RA)**Abbreviations used in this paper: APL, acute promyelocytic leukemia; dnRARα, dominant–negative version of the RARα; E, embryonic age; HDAC, histone deacetylase; LCoR, ligand-dependent corepressor; NCoR, nuclear receptor corepressor; RA, retinoic acid; RAR, RA receptor; RARE, RXR homodimer bound to bipartite response element; RXR, retinoid X receptor; TSA, trichostatin A; CYP26, cytochrome p450, 26; TR, thyroid hormone receptor. receptor (RAR) fusion proteins, blocks myeloid differentiation leading to a rare form of leukemia. Our current understanding of the developmental role of retinoid repression and future perspectives in this field are discussed.
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Mohd Ali, Nor Aishah, Zurina Shafii, and Shahida Shahimi. "Competency model for Shari’ah auditors in Islamic banks." Journal of Islamic Accounting and Business Research 11, no. 2 (2020): 377–99. http://dx.doi.org/10.1108/jiabr-09-2016-0106.
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Purpose The purpose of this study is to identify the competencies required of Shari’ah auditor (SAR) in the Islamic banking environment. Design/methodology/approach A qualitative approach using a multiple-case study through the semi-structured interview was used. Data was gathered from a representative of Central Bank of Malaysia, and 30 other respondents consist of the Head of Shari’ah audit (HSA) and SAR from four types of banking institutions. A focus group discussion was later conducted to validate the model of competency proposed. Findings Results show a mixed practice on the recruitment of SAR. Most banking institutions prefer to use their existing internal auditors as opposed to recruiting fresh graduates or acquire experienced SAR from other financial institutions. Knowledge in Shari’ah, Islamic banking and Fiqh Muamalat is considered as the essential knowledge component for SAR, while auditing is revealed as the core skill that SAR should have to perform the Shari’ah audit effectively. The study also found that personal skills such as willingness to learn and teamwork as the complementing characteristics to the knowledge and skill components, as a package required for a competent SAR. Research limitations/implications The results of this study would have both theoretical and practical contributions to the regulatory bodies, academicians and professionals. Theoretically, this study made a concerted effort to enhance prior studies on the qualification aspect of Shari’ah audit literature, emphasizing the elements necessary to recruit competent SARs in the Islamic financial institutions (IFIs). The element of “time” has been infused to the existing effective job performance theory add dynamics to the model, recognizing the need for years of experience as part of elements necessary to become competent SAR. In practice, the competency model is recommended to the industry players in pooling competent talents in the Islamic finance industry (R4) and (B5). In spite of its limitation to confine only to the IFIs, it sheds light on human resource management within the Islamic organizations. Practical implications The study would contribute to the practitioners as a guideline to the Human Resource Department in recruiting their SAR and also for succession planning purposes. Originality/value A competency model for SAR was proposed focusing on building knowledge, core and personal skills that can be used as guidance in determining the criteria needed for a competent SAR, which is a new dimension for Islamic auditing literature. The sub-objective of determining the elements of competency, as well as understanding the current practice of recruiting the SAR became the input in the building of the competency model.
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Lu, Weidong, Jochen H. Lorch, Peter M. Wayne, et al. "Acupuncture for dysphagia after chemoradiation therapy in head and neck cancer: A randomized sham-controlled study." Journal of Clinical Oncology 31, no. 15_suppl (2013): 6058. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.6058.
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6058 Background: Dysphagia is a common side effect following chemoradiation (CRT) in pts with head and neck cancer (HNC). The purpose of this pilot trial was to assess the feasibility of recruiting HNC pts and to collect preliminary data on the efficacy and safety of acupuncture on dysphagia-related QOL. Methods: Pts were eligible if diagnosed with stage III-IV HNC, without evidence of distance metastasis, receiving curative-intent CRT. Pts were randomized to 12 sessions of either active or sham acupuncture, once every two weeks, over 24 weeks from during CRT to 20-week post-CRT. All study personnel and the pts were blinded; the treating acupuncturists were not. MDADI and other questionnaires were measured at baseline (end of CRT), end of acupuncture, and at six months follow-up (12-month post-CRT). Data were analyzed by repeated-measures ANOVA adjusting for baseline. Results: Accrual was completed in December 2011. Among 42 pts enrolled, 35 (83%) received at least 8 sessions of acupuncture, and 28 (67%) received all 12. Six pts withdrew due to time constraints. No serious side effects were observed. The mean MDADI total scores improved from baseline in both treatment arms [64.5 (SE+2.4) vs. 71.4 (SE±3.1), p = 0.048; 64.5 (SE±2.4) vs. 77.8 (SE±3.0), p< 0.001]; the difference in improvement was not significant (p = 0.12). The median feeding tube duration did not differ between active and sham treatments (n = 39, median 125 days vs. 147 days, p = 0.93). Conclusions: Acupuncture is a safe and feasible treatment for HNC pts. There were improvements in QOL parameters from end of CRT to the time points examined that did not differ between the two arms. Efficacy of acupuncture to improve swallowing-related QOL in HNC pts may require more frequent or longer duration of treatment. Clinical trial information: NCT00797732.
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Kutila, M. H., M. Jokela, T. Mäkinen, J. Viitanen, G. Markkula, and T. W. Victor. "Driver cognitive distraction detection: Feature estimation and implementation." Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering 221, no. 9 (2007): 1027–40. http://dx.doi.org/10.1243/09544070jauto332.
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This article focuses on monitoring a driver's cognitive impairment due to talking to passengers or on a mobile phone, daydreaming, or just thinking about other than driving-related matters. This paper describes an investigation of cognitive distraction, firstly, giving an overall idea of its effects on the driver and, secondly, discussing the practical implementation of an algorithm for detection of cognitive distraction using a support vector machine (SVM) classifier. The evaluation data have been gathered by recruiting 12 professional drivers to drive for approximately 45 min in various environments and inducing cognitive tasks, i.e. arithmetic calculations. According to the prior knowledge and the experimental analysis, gaze, head and lane-keeping variances over a 15 s time window were selected indicative features. The SVM classifier's performance was optimized through exhaustive parameter tuning. The executed tests show that the cognitive workload can be detected with approximately 65-80 per cent confidence despite the fact that the test material represented medium-difficulty cognitive tasks (i.e. the induced workload was not very high). Thus, it could be assumed that a more challenging cognitive task would yield better detection results.
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Steed, Kevin, John De Nobile, and Manjula Waniganayake. "Merit selecting school leaders: Australian principals' perspectives." International Journal of Educational Management 34, no. 8 (2020): 1303–15. http://dx.doi.org/10.1108/ijem-12-2019-0417.
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PurposeThis research paper explores the perspectives of Australian school principals in the state of New South Wales (NSW) regarding what they believe constitutes “merit” when selecting deputy principals, assistant principals (primary) and head teachers (secondary).Design/methodology/approachAn online survey was utilised to collect qualitative and quantitative data from school principals across the state of NSW to investigate their understanding of, and approach to, the merit selection of their respective school leadership cadres.FindingsStudy findings indicated a statewide variance in the perceptions of principals when identifying merit for the purposes of recruiting school leadership teams. These findings question the widely held view that candidates compete for school leadership positions on a level playing field.Practical implicationsIn practical terms, the findings indicate that NSW school principals would benefit from more intensive professional learning opportunities designed to enhance their ability to objectively identify and assess merit when selecting school leaders.Originality/valueThis study contributes to an enhanced understanding in an area where there is a paucity of research-based evidence focusing upon the perspectives of school principals regarding their understanding of meritocratic theory and its influence on their school leadership selection practice.
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Subramanian, Ram, Tripti Singh, Ram Misra, and C. Jayachandran. "Infosys Technologies Limited: The Global Talent Program." Asian Case Research Journal 12, no. 02 (2008): 249–73. http://dx.doi.org/10.1142/s0218927508001126.
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Infosys Technologies Limited, the Bangalore-based information technology company, embarked on a global recruitment program in 2006. The first batch of recruits from U.S. universities were brought to the company's Mysore training facility in India and put through a rigorous 16-week training program. By November 2007, the third U.S. batch was on campus for training along with the first batch from the U.K. Each of these batches had around 125 recruits. The company's CEO had charged Infosys' Head of Administration and Human Resources Development, Mohandas Pai, to step up the recruiting to around 1,000 overseas recruits a year from countries such as the US, UK, continental Europe, and China as a way to globalize the workforce. Pai was concerned that this ambitious recruitment program would strain the company's training function. His concern stemmed from the fact that the trainers had to deal with cultural differences and varied learning styles of overseas recruits. The trainers had done a commendable job of making adjustments while training was ongoing, but Pai wondered if the same adjustments could be made when the scale of recruits increased dramatically. This case is useful for examining the issues of training capacity and cross-cultural training.
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Ali, Nor Aishah Mohd, and Nawal Kasim. "Talent Management for Shariah Auditors: Case Study Evidence From the Practitioners." International Journal of Financial Research 10, no. 3 (2019): 252. http://dx.doi.org/10.5430/ijfr.v10n3p252.
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The environment for most financial institutions today is complex, dynamic, highly competitive, and extremely volatile, and such condition is likely to remain for years to come. In addition to these external situations, most financial institutions also faced the challenge to manage talents flow in particular, a shortage of needed competencies. One measure to overcome this condition is to be systematic in managing their human capital if they wish to gain and sustain a competitive advantage in years ahead. This paper postulates to explore the competency criteria as one of talent management for shariah auditors in the Islamic Financial Institutions (IFIs) in Malaysia. A qualitative design was adopted by conducting interviews with 30 practitioners consisting of the Heads of Shariah audit departments (HSA) and shariah auditors (SAR) from the IFIs and the Head of Islamic banking department from the Central Bank of Malaysia. This is followed by a focus group discussion to validate the findings. The study found that there was mixed practices on talent management in terms of competency aspect required for shariah auditors. Generally, participants agreed that certain skills, knowledge and characteristics added with years of experience in the field, are pre-requisite to become competent shariah auditors. This study is unique as it explores the case from the qualitative stance. Opinions were elicited from the parties directly involved in preparing guidelines to the IFIs as well as those practitioners executing the shariah audit function within their institutions. IFIs will have better guideline on recruiting competent future shariah auditors, as part of their internal audit team to uphold the shariah precept.
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Bauman, Julie E., Garth T. Olson, Michael Spafford, et al. "A pilot study of raltegravir and cisplatin in head and neck squamous cell carcinoma (HNSCC)." Journal of Clinical Oncology 30, no. 15_suppl (2012): TPS5602. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.tps5602.
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TPS5602 Background: Metnase is a recently characterized DNA repair component present in anthropoid primates. Metnase, the fusion of a SET histone methylase domain and a Transposase nuclease (Tn) domain, enhances DNA double-stranded break (DSB) repair. The Tn domain trims free DNA ends for optimal end-joining, and is required to re-start stalled replication forks. The SET domain di-methylates H3K36 at the DSB, recruiting non-homologous end-joining repair components. Cisplatin (CDDP), the central chemotherapy in HNSCC, covalently binds DNA leading to intra- and interstrand crosslinks (ICL). In addition to blocking strand transcription and segregation, the ICL stalls DNA replication fork progression leading to collapse and DSB. The role of Metnase in DNA repair, including overcoming the stalled replication fork, makes it a potential therapeutic target. We hypothesize that Metnase inhibition may be a useful adjunct to CDDP. 3D modeling of the Metnase Tn domain identified significant homology with human immunodeficiency virus 1 (HIV-1) integrase. A virtual screen of the Chem Div library identified the HIV-1 integrase inhibitor, raltegravir, as a lead compound for inhibiting the Metnase Tn domain. We designed a pilot study in HNSCC to evaluate potentiation of CDDP DNA damage by raltegravir. Methods: The primary objective of this window-of-opportunity study is to analyze biomarkers of DNA damage, fork arrest, and apoptosis in serial tumor biopsies from patients (pts) with HNSCC undergoing CDDP, with and without raltegravir. Eligible pts: 1) have HNSCC with tumor site amenable to repeat, awake biopsy; 2) are appropriate candidates for CDDP. Pts are treated with 2 doses of CDDP 30 mg/m2. One CDDP dose is administered with raltegravir 400 mg bid for 5 days, starting the day before CDDP. Pts undergo 3 research biopsies, at baseline and 48-72 hours after each CDDP. Serial biopsies will be evaluated for expression changes in γH2AX, Annexin V, pChk1, pChk2, and p53BP1 by immunohistochemistry. Numerical increase in biomarker expression in tumors exposed to CDDP-raltegravir vs. CDDP will justify development of a phase I/II study. Four of 12 pts have enrolled and completed all biopsies. Supported by a grant from the American Cancer Society.
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Schuster, Philipp, Georg Lindner, Sabrina Thomann, Sebastian Haferkamp, and Barbara Schmidt. "Prospect of Plasmacytoid Dendritic Cells in Enhancing Anti-Tumor Immunity of Oncolytic Herpes Viruses." Cancers 11, no. 5 (2019): 651. http://dx.doi.org/10.3390/cancers11050651.
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The major type I interferon-producing plasmacytoid dendritic cells (pDC) surround and infiltrate certain tumors like malignant melanoma, head and neck cancer, and ovarian and breast cancer. The presence of pDC in these tumors is associated with an unfavorable prognosis for the patients as long as these cells are unstimulated. Upon activation by synthetic Toll-like receptor agonists or viruses, however, pDC develop cytotoxic activities. Viruses have the additional advantage to augment cytotoxic activities of pDC via lytic replication in malignant lesions. These effects turn cold tumors into hotspots, recruiting further immune cells to the site of inflammation. Activated pDC contribute to cross-presentation of tumor-associated antigens by classical dendritic cells, which induce cytotoxic T-cells in particular in the presence of checkpoint inhibitors. The modification of oncolytic herpes viruses via genetic engineering favorably affects this process through the enhanced production of pro-inflammatory cytokines, curbing of tumor blood supply, and removal of extracellular barriers for efficient viral spread. Importantly, viral vectors may contribute to stimulation of memory-type adaptive immune responses through presentation of tumor-related neo- and/or self-antigens. Eventually, both replication-competent and replication-deficient herpes simplex virus 1 (HSV-1) may serve as vaccine vectors, which contribute to tumor regression by the stimulation of pDC and other dendritic cells in adjuvant and neo-adjuvant situations.
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Black, Christopher J., Elyse R. Thakur, Lesley A. Houghton, Eamonn M. M. Quigley, Paul Moayyedi, and Alexander C. Ford. "Efficacy of psychological therapies for irritable bowel syndrome: systematic review and network meta-analysis." Gut 69, no. 8 (2020): 1441–51. http://dx.doi.org/10.1136/gutjnl-2020-321191.
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ObjectivesNational guidelines for the management of irritable bowel syndrome (IBS) recommend that psychological therapies should be considered, but their relative efficacy is unknown, because there have been few head-to-head trials. We performed a systematic review and network meta-analysis to try to resolve this uncertainty.DesignWe searched the medical literature through January 2020 for randomised controlled trials (RCTs) assessing efficacy of psychological therapies for adults with IBS, compared with each other, or a control intervention. Trials reported a dichotomous assessment of symptom status after completion of therapy. We pooled data using a random effects model. Efficacy was reported as a pooled relative risk (RR) of remaining symptomatic, with a 95% CI to summarise efficacy of each comparison tested, and ranked by therapy according to P score.ResultsWe identified 41 eligible RCTs, containing 4072 participants. After completion of therapy, the psychological interventions with the largest numbers of trials, and patients recruited, demonstrating efficacy included self-administered or minimal contact cognitive behavioural therapy (CBT) (RR 0.61; 95% CI 0.45 to 0.83, P score 0.66), face-to-face CBT (RR 0.62; 95% CI 0.48 to 0.80, P score 0.65) and gut-directed hypnotherapy (RR 0.67; 95% CI 0.49 to 0.91, P score 0.57). After completion of therapy, among trials recruiting only patients with refractory symptoms, group CBT and gut-directed hypnotherapy were more efficacious than either education and/or support or routine care, and CBT via the telephone, contingency management, CBT via the internet and dynamic psychotherapy were all superior to routine care. Risk of bias of trials was high, with evidence of funnel plot asymmetry; the efficacy of psychological therapies is therefore likely to have been overestimated.ConclusionsSeveral psychological therapies are efficacious for IBS, although none were superior to another. CBT-based interventions and gut-directed hypnotherapy had the largest evidence base and were the most efficacious long term.Trial registration numberThe study protocol was published on the PROSPERO international prospective register of systematic reviews (registration number CRD 42020163246).
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Yu, Xinzhe, and Ping Yi. "Structural Insights of Transcriptionally Active, Full-Length Androgen Receptor Coactivator Complexes." Journal of the Endocrine Society 5, Supplement_1 (2021): A817. http://dx.doi.org/10.1210/jendso/bvab048.1665.
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Abstract Steroid hormone receptors activate gene transcription by binding specific DNA sequences and recruiting coactivators to initiate transcription of their target genes. For most nuclear hormone receptors (NRs), the ligand-dependent activation function domain-2 (AF-2), residing in the C-terminal ligand binding domain (LBD), is a primary contributor to the NR transcriptional activity. In contrast to other steroid receptors such as estrogen receptor-α (ERα), the transcriptional activation function of androgen receptor (AR) is thought to be largely dependent on its ligand-independent activation function domain-1 (AF-1) located in its N-terminal domain (NTD). It remains unclear why AR utilizes a different activation function domain from other steroid receptors despite the fact that NRs share similar domain organizations and have a highly conserved DNA binding domain (DBD) and LBD. Here we present cryo-electron microscopic structures of DNA-bound full-length AR and its functional complex structure with its key coactivators, steroid receptor coactivator-3 (SRC-3) and the histone acetyltransferase p300. The structures reveal that androgen-bound full-length AR dimerization follows a unique head-to-head and tail-to-tail manner with all of the domains involved. The DBD and LBD are located at the center of the dimer interface. The NTDs wrap around the LBDs through their unique intra- and inter-molecular N- and C-terminal interactions and connect to each other. We observe that unlike ERα, AR binds a single SRC-3 molecule along with a single p300 molecule. The AR NTD appears to be the primary site for recruitment of both coactivators. The N-terminal region of SRC-3, rather than its receptor interaction domain, is important for this interaction. The structures presented here highlight the importance of the AR NTD for its transcriptional functions and provide a structural basis for understanding the assembly of the AR:coactivator complex and its domain contributions to transcriptional regulation.
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Kerr, Nadine, Juan de Rivero Vaccari, Oliver Umland, et al. "Human Lung Cell Pyroptosis Following Traumatic Brain Injury." Cells 8, no. 1 (2019): 69. http://dx.doi.org/10.3390/cells8010069.
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Approximately 30% of traumatic brain injured patients suffer from acute lung injury or acute respiratory distress syndrome. Our previous work revealed that extracellular vesicle (EV)-mediated inflammasome signaling plays a crucial role in the pathophysiology of traumatic brain injury (TBI)-induced lung injury. Here, serum-derived EVs from severe TBI patients were analyzed for particle size, concentration, origin, and levels of the inflammasome component, an apoptosis-associated speck-like protein containing a caspase-recruiting domain (ASC). Serum ASC levels were analyzed from EV obtained from patients that presented lung injury after TBI and compared them to EV obtained from patients that did not show any signs of lung injury. EVs were co-cultured with lung human microvascular endothelial cells (HMVEC-L) to evaluate inflammasome activation and endothelial cell pyroptosis. TBI patients had a significant increase in the number of serum-derived EVs and levels of ASC. Severe TBI patients with lung injury had a significantly higher level of ASC in serum and serum-derived EVs compared to individuals without lung injury. Only EVs isolated from head trauma patients with gunshot wounds were of neural origin. Delivery of serum-derived EVs to HMVEC-L activated the inflammasome and resulted in endothelial cell pyroptosis. Thus, serum-derived EVs and inflammasome proteins play a critical role in the pathogenesis of TBI-induced lung injury, supporting activation of an EV-mediated neural-respiratory inflammasome axis in TBI-induced lung injury.
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Nunes, Maria Vania Silva, Alexandre Castro-Caldas, Dolores Del Rio, Fernado Maestú, and Tomás Ortiz. "The ex-illiterate brain: The critical period, cognitive reserve and HAROLD model." Dementia & Neuropsychologia 3, no. 3 (2009): 222–27. http://dx.doi.org/10.1590/s1980-57642009dn30300008.
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Abstract The lifelong acquisition of cognitive skills shapes the biology of the brain. However, there are critical periods for the best use of the brain to process the acquired information. Objectives: To discuss the critical period of cognitive acquisition, the concept of cognitive reserve and the HAROLD (Hemispheric Asymmetry Reduction in Older adults) model. Methods: Seven women who learned how to read and to write after the age of 50 (ex-illiterates) and five women with 10 years of regular schooling (controls) were submitted to a language recognition test while brain activity was being recorded using magnetoencephalography. Spoken words were delivered binaurally via two plastic tubs terminating in ear inserts, and recordings were made with a whole head magnetometer consisting of 148 magnetometer coils. Results: Both groups performed similarly on the task of identifying target words. Analysis of the number of sources of activity in the left and right hemispheres revealed significant differences between the two groups, showing that ex-illiterate subjects exhibited less brain functional asymmetry during the language task. Conclusions: These results should be interpreted with caution because the groups were small. However, these findings reinforce the concept that poorly educated subjects tend to use the brain for information processing in a different way to subjects with a high educational level or who were schooled at the regular time. Finally, the recruiting of both hemispheres to tackle the language recognition test occurred to a greater degree in the ex-illiterate group where this can be interpreted as a sign of difficulty performing the task.
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Cheng, Ran, Sandrine Billet, Chuanxia Liu, et al. "Periodontal inflammation recruits distant metastatic breast cancer cells by increasing myeloid-derived suppressor cells." Oncogene 39, no. 7 (2019): 1543–56. http://dx.doi.org/10.1038/s41388-019-1084-z.
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Abstract Periodontal diseases can lead to chronic inflammation affecting the integrity of the tooth supporting tissues. Recently, a striking association has been made between periodontal diseases and primary cancers in the absence of a mechanistic understanding. Here we address the effect of periodontal inflammation (PI) on tumor progression, metastasis, and possible underlining mechanisms. We show that an experimental model of PI in mice can promote lymph node (LN) micrometastasis, as well as head and neck metastasis of 4T1 breast cancer cells, both in early and late stages of cancer progression. The cervical LNs had a greater tumor burden and infiltration of MDSC and M2 macrophages compared with LNs at other sites. Pyroptosis and the resultant IL-1β production were detected in patients with PI, mirrored in mouse models. Anakinra, IL-1 receptor antagonist, limited metastasis, and MDSC recruitment at early stages of tumor progression, but failed to reverse established metastatic tumors. PI and the resulting production of IL-1β was found to promote CCL5, CXCL12, CCL2, and CXCL5 expression. These chemokines recruit MDSC and macrophages, finally enabling the generation of a premetastatic niche in the inflammatory site. These findings support the idea that periodontal inflammation promotes metastasis of breast cancer by recruiting MDSC in part by pyroptosis-induced IL-1β generation and downstream CCL2, CCL5, and CXCL5 signaling in the early steps of metastasis. These studies define the role for IL-1β in the metastatic progression of breast cancer and highlight the need to control PI, a pervasive inflammatory condition in older patients.
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Morfouace, Marie, Aleksandra Stevovic, Marie Vinches, et al. "First results of the EORTC-SPECTA/Arcagen study exploring the genomics of rare cancers in collaboration with the European reference network EURACAN." ESMO Open 5, no. 6 (2020): e001075. http://dx.doi.org/10.1136/esmoopen-2020-001075.
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PurposeRare cancers are defined by an incidence of <6 out of 100 000 cases per year. They are under-represented in clinical research including tumour molecular analysis. The aim of Arcagen is to generate a multinational database integrating clinical and molecular information of patients with rare cancers.Patients and methodsWe present the retrospective feasibility cohort of patients with rare cancers, with previously collected tumour samples available from any stage. Molecular analysis was performed using FoundationOne CDx for all histologies except for sarcoma where FoundationOne Heme was used. Clinical data including demographic data, medical history, malignant history, treatment and survival data were collected.ResultsEighty-seven patients from three centres were screened; molecular data were obtained for 77 patients (41 sarcomas, 9 yolk sac tumours, 14 rare head and neck cancers, 13 thymomas). The median age at the time of diagnosis was 48 (range 28–85). Most patients had reportable genomic alterations (89%). The most common alterations were linked to cell cycle regulation (TP53, RB1, CDKN2A/B deletions and MDM2 amplification). Multiple activating single-nucleotide variants (SNVs) could be detected in the RAS/RAF family. The tumour mutational burden status was globally low across all samples with a median of 3 Muts/MB (range 0–52). Only 4 cases (ie, 4.7% of tumours) had direct actionable mutations for a treatment approved in Europe within the patient’s tumour type.ConclusionThe Arcagen project aims to bridge the gap and improve knowledge of the molecular landscape of rare cancers by prospectively recruiting up to 1000 patients.
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Quinet, Julie, and Laurent Goffart. "Cerebellar control of saccade dynamics: contribution of the fastigial oculomotor region." Journal of Neurophysiology 113, no. 9 (2015): 3323–36. http://dx.doi.org/10.1152/jn.01021.2014.
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The fastigial oculomotor region is the output by which the medioposterior cerebellum influences the generation of saccades. Recent inactivation studies reported observations suggesting an involvement in their dynamics (velocity and duration). In this work, we tested this hypothesis in the head-restrained monkey with the electrical microstimulation technique. More specifically, we studied the influence of duration, frequency, and current on the saccades elicited by fastigial stimulation and starting from a central (straight ahead) position. The results show ipsilateral or contralateral saccades whose amplitude and dynamics depend on the stimulation parameters. The duration and amplitude of their horizontal component increase with the duration of stimulation up to a maximum amplitude. Varying the stimulation frequency mostly changes their latency and the peak velocity (for contralateral saccades). Current also influences the metrics and dynamics of saccades: the horizontal amplitude and peak velocity increase with the intensity, whereas the latency decreases. The changes in peak velocity and in latency observed in contralateral saccades are not correlated. Finally, we discovered that contralateral saccades can be evoked at sites eliciting ipsilateral saccades when the stimulation frequency is reduced. However, their onset is timed not with the onset but with the offset of stimulation. These results corroborate the hypothesis that the fastigial projections toward the pontomedullary reticular formation (PMRF) participate in steering the saccade, whereas the fastigiocollicular projections contribute to the bilateral control of visual fixation. We propose that the cerebellar influence on saccade generation involves recruiting neurons and controlling the size of the active population in the PMRF.
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Vasilyev, Alexey V. "Military clergy reorganization in the Paul’s I of Russia military reform." RUDN Journal of Russian History 20, no. 3 (2021): 426–36. http://dx.doi.org/10.22363/2312-8674-2021-20-3-426-436.
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The article examines an important historical stage in the development of military clergy. During this period, effective systems of military administration, training and recruitment and social protection of its members were established. In the process of the Emperor Paul's reform the military clergy acquired the features of a political institution. This was manifested in the active intervention of the state in the managerial system of the clergy. And the head of the military priests becomes the ober-priest of the Russian army and navy. A system of candidates selection for the positions of military priests has been built. A specialized educational institution was established for recruiting military clergy from the children of military clergy - the Army Seminary. After leaving the military department, martial ober-priests are provided with places in urban parishes, and martial priests are appointed to the rural churches of the dioceses from which they came to serve. A pension was introduced for the military clergy who were unable to continue serving because of age or illness. The military clergy were extracted from the subordination of the Holy Synod. And in the person of the ober-priest it was subordinated to the highest political leadership. As a result, the organization of the military clergy, which was optimal from the point of view of military-political management and effective use, was integrated into the military organization of the state. But this came into conflict with the canonical church norms and the position of the holy synod. After the tragic death of emperor Paul, this organization was largely dismantled.
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Xin, Wei, Shuai Yuan, Bo Wang, Qirong Qian, and Yi Chen. "Hsa_circ_0066523 promotes the proliferation and osteogenic differentiation of bone mesenchymal stem cells by repressing PTEN." Bone & Joint Research 10, no. 8 (2021): 526–35. http://dx.doi.org/10.1302/2046-3758.108.bjr-2020-0127.r2.
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Aims Circular RNAs (circRNAs) are a novel type of non-coding RNA that plays major roles in the development of diverse diseases including osteonecrosis of the femoral head (ONFH). Here, we explored the impact of hsa_circ_0066523 derived from forkhead box P1 (FOXP1) (also called circFOXP1) on bone mesenchymal stem cells (BMSCs), which is important for ONFH development. Methods RNA or protein expression in BMSCs was analyzed by quantitative real-time polymerase chain reaction (qRT-PCR) or western blot, respectively. Cell Counting Kit 8 (CCK8) and 5-ethynyl-2’-deoxyuridine (EdU) were used to analyze cell proliferation. Alkaline phosphatase (ALP) activity, ALP staining, and Alizarin Red S staining were employed to evaluate the osteoblastic differentiation. Chromatin immunoprecipitation (ChIP), luciferase reporter, RNA pull down, and RNA immunoprecipitation (RIP) assays were combined for exploring molecular associations. Results Circ_0066523 was upregulated in osteogenic induction process of BMSCs. Silencing circ_0066523 restrained the proliferation and osteogenic differentiation of BMSCs. Mechanistically, circ_0066523 activated phosphatidylinositol-4,5-bisphosphate 3-kinase / AKT serine/threonine kinase 1 (PI3K/AKT) pathway via recruiting lysine demethylase 5B (KDM5B) to epigenetically repress the transcription of phosphatase and tensin homolog (PTEN). Functionally, AKT signalling pathway agonist or PTEN knockdown counteracted the effects of silenced circ_0066523 on BMSC proliferation and differentiation. Conclusion Circ_0066523 promotes the proliferation and differentiation of BMSCs by epigenetically repressing PTEN and therefore activating AKT pathway. This finding might open new avenues for the identification of therapeutic targets for osteoblast differentiation related diseases such as ONFH. Cite this article: Bone Joint Res 2021;10(8):526–535.
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Kong, Anthony, James Good, Amanda Kirkham, et al. "Phase I trial of WEE1 inhibition with chemotherapy and radiotherapy as adjuvant treatment, and a window of opportunity trial with cisplatin in patients with head and neck cancer: theWISTERIAtrial protocol." BMJ Open 10, no. 3 (2020): e033009. http://dx.doi.org/10.1136/bmjopen-2019-033009.
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IntroductionPatients with head and neck squamous cell carcinoma with locally advanced disease often require multimodality treatment with surgery, radiotherapy and/or chemotherapy. Adjuvant radiotherapy with concurrent chemotherapy is offered to patients with high-risk pathological features postsurgery. While cure rates are improved, overall survival remains suboptimal and treatment has a significant negative impact on quality of life.Cell cycle checkpoint kinase inhibition is a promising method to selectively potentiate the therapeutic effects of chemoradiation. Our hypothesis is that combining chemoradiation with a WEE1 inhibitor will affect the biological response to DNA damage caused by cisplatin and radiation, thereby enhancing clinical outcomes, without increased toxicity. This trial explores the associated effect of WEE1 kinase inhibitor adavosertib (AZD1775).Methods and analysisThis phase I dose-finding, open-label, multicentre trial aims to determine the highest safe dose of AZD1775 in combination with cisplatin chemotherapy preoperatively (group A) as a window of opportunity trial, and in combination with postoperative cisplatin-based chemoradiation (group B).Modified time-to-event continual reassessment method will determine the recommended dose, recruiting up to 21 patients per group. Primary outcomes are recommended doses with predefined target dose-limiting toxicity probabilities of 25% monitored up to 42 days (group A), and 30% monitored up to 12 weeks (group B). Secondary outcomes are disease-free survival times (groups A and B). Exploratory objectives are evaluation of pharmacodynamic (PD) effects, identification and correlation of potential biomarkers with PD markers of DNA damage, determine rate of resection status and surgical complications for group A; and quality of life in group B.Ethics and disseminationResearch Ethics Committee, Edgbaston, West Midlands (REC reference 16/WM/0501) initial approval received on 18/01/2017. Results will be disseminated via peer-reviewed publication and presentation at international conferences.Trial registration numberISRCTN76291951andNCT03028766.